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William Bowers

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Sara L Montgomery; William J Bowers
Tumor necrosis factor-alpha and the roles it plays in homeostatic and degenerative processes within the central nervous system.
Guillermo García Alías; Philip J Horner; Lorne Mendell; Hayk A Petrosyan; Lisa Schnell; William J Bowers; James W Fawcett; Victor L Arvanian
Chondroitinase ABC combined with neurotrophin NT-3 secretion and NR2D expression promotes axonal plasticity and functional recovery in rats with lateral hemisection of the spinal cord.
Lisa Schnell; Martin E Schwab; William J Bowers; Howard J Federoff; Miriam Gullo; Philip J Horner; Arsen S Hunanyan; Lorne Mendell; Victor L Arvanian
Combined delivery of Nogo-A antibody, neurotrophin-3 and the NMDA-NR2d subunit establishes a functional 'detour' in the hemisected spinal cord.

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All Publications

2012: Sara L Montgomery; William J Bowers
Tumor necrosis factor-alpha and the roles it plays in homeostatic and degenerative processes within the central nervous system.
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 2012;7(1):42-59.
2011: Guillermo García Alías; Philip J Horner; Lorne Mendell; Hayk A Petrosyan; Lisa Schnell; William J Bowers; James W Fawcett; Victor L Arvanian
Chondroitinase ABC combined with neurotrophin NT-3 secretion and NR2D expression promotes axonal plasticity and functional recovery in rats with lateral hemisection of the spinal cord.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011;31(49):17788-99.
2011: Lisa Schnell; Martin E Schwab; William J Bowers; Howard J Federoff; Miriam Gullo; Philip J Horner; Arsen S Hunanyan; Lorne Mendell; Victor L Arvanian
Combined delivery of Nogo-A antibody, neurotrophin-3 and the NMDA-NR2d subunit establishes a functional 'detour' in the hemisected spinal cord.
The European journal of neuroscience 2011;34(8):1256-67.
2011: Sara L Montgomery; Wade C Narrow; Terry W Wright; Diala Habib; Sara A Knowlden; Michael A Mastrangelo; William J Bowers
Ablation of TNF-RI/RII expression in Alzheimer's disease mice leads to an unexpected enhancement of pathology: implications for chronic pan-TNF-α suppressive therapeutic strategies in the brain.
The American journal of pathology 2011;179(4):2053-70.
2011: Suresh de Silva; William J Bowers
Targeting the central nervous system with herpes simplex virus / Sleeping Beauty hybrid amplicon vectors.
Current gene therapy 2011;11(5):332-40.
2011: William Domm; Changyong Feng; James L McGrath; Gene Watson; William J Bowers; Lauren Brooks; Hung Li Chung; Stephen Dewhurst
Robust antigen-specific humoral immune responses to sublingually delivered adenoviral vectors encoding HIV-1 Env: association with mucoadhesion and efficient penetration of the sublingual barrier.
Vaccine 2011;29(40):7080-9.
2011: William J Bowers; Xandra O Breakefield; Miguel Sena-Esteves
Genetic therapy for the nervous system.
Human molecular genetics 2011;20(R1):R28-41.
2011: Maya K Desai; Brendan J Guercio; Wade C Narrow; William J Bowers
An Alzheimer's disease-relevant presenilin-1 mutation augments amyloid-beta-induced oligodendrocyte dysfunction.
Glia 2011;59(4):627-40.
2011: Polyxeni Philippidou; Gregorio Valdez; Wendy Akmentin; William J Bowers; Howard Federoff; Simon Halegoua
Trk retrograde signaling requires persistent, Pincher-directed endosomes.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(2):852-7.
2011: Piotr Hadaczek; Adrian Kells; Wade Narrow; Janine Beyer; William J Bowers; Howard J Federoff; John R Forsayeth; Krystof Bankiewicz
Evaluation of an AAV2-based rapamycin-regulated glial cell line-derived neurotrophic factor (GDNF) expression vector system.
PloS one 2011;6(11):e27728.
2011: Jesse M Hunter; Walter Kalback; Tyler A Kokjohn; Dean C Luehrs; Chera L Maarouf; Michael A Mastrangelo; Thomas Beach; William J Bowers; Ian D Daugs; Jon Valla; Alex Roher
Biochemical and morphological characterization of the AβPP/PS/tau triple transgenic mouse model and its relevance to sporadic Alzheimer's disease.
Journal of Alzheimer's disease : JAD 2011;27(2):361-76.
2011: Mitra azadniv; William J Bowers; David J Topham; Ian N Crispe
CD4+ T cell effects on CD8+ T cell location defined using bioluminescence.
PloS one 2011;6(1):e16222.
2010: Suresh de Silva; Louis T Lotta; Clark A Burris; William J Bowers
Virion-associated cofactor high-mobility group DNA-binding protein-1 facilitates transposition from the herpes simplex virus/Sleeping Beauty amplicon vector platform.
Human gene therapy 2010;21(11):1615-22.
2010: Suresh de Silva; Michael A Mastrangelo; Louis T Lotta; Clark A Burris; Zsuzsanna Izsvák; Zoltán Ivics; William J Bowers
Herpes simplex virus/Sleeping Beauty vector-based embryonic gene transfer using the HSB5 mutant: loss of apparent transposition hyperactivity in vivo.
Human gene therapy 2010;21(11):1603-13.
2010: Byoung Dae Lee; Joo-Ho Shin; Jackalina VanKampen; Leonard Petrucelli; Andrew B West; Han Seok Ko; Yun-Il Lee; Kathleen A Maguire-Zeiss; William J Bowers; Howard Federoff; Valina Dawson; Ted M Dawson
Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's disease.
Nature medicine 2010;16(9):998-1000.
2010: Maya K Desai; Michael A Mastrangelo; Deborah A Ryan; Kelly L Sudol; Wade C Narrow; William J Bowers
Early oligodendrocyte/myelin pathology in Alzheimer's disease mice constitutes a novel therapeutic target.
The American journal of pathology 2010;177(3):1422-35.
2010: Deborah A Ryan; Michael A Mastrangelo; Wade C Narrow; Mark A Sullivan; Howard Federoff; William J Bowers
Abeta-directed single-chain antibody delivery via a serotype-1 AAV vector improves learning behavior and pathology in Alzheimer's disease mice.
Molecular therapy : the journal of the American Society of Gene Therapy 2010;18(8):1471-81.
2010: Deborah A Ryan; Wade C Narrow; Howard Federoff; William J Bowers
An improved method for generating consistent soluble amyloid-beta oligomer preparations for in vitro neurotoxicity studies.
Journal of neuroscience methods 2010;190(2):171-9.
2010: Adrian P Kells; Jamie L Eberling; Xiaomin Su; Phillip Pivirotto; John Bringas; Piotr Hadaczek; Wade C Narrow; William J Bowers; Howard Federoff; John R Forsayeth; Krystof S Bankiewicz
Regeneration of the MPTP-lesioned dopaminergic system after convection-enhanced delivery of AAV2-GDNF.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010;30(28):9567-77.
2010: Keigan M Park; William J Bowers
Tumor necrosis factor-alpha mediated signaling in neuronal homeostasis and dysfunction.
Cellular signalling 2010;22(7):977-83.
2010: Yulan Xiong; Candice E Coombes; Austin Kilaru; Xiaojie Li; Aaron D Gitler; William J Bowers; Valina Dawson; Ted M Dawson; Darren J Moore
GTPase activity plays a key role in the pathobiology of LRRK2.
PLoS genetics 2010;6(4):e1000902.
2010: Keigan M Park; David I Yule; William J Bowers
Impaired TNF-alpha control of IP3R-mediated Ca2+ release in Alzheimer's disease mouse neurons.
Cellular signalling 2010;22(3):519-26.
2010: S de Silva; Michael A Mastrangelo; L T Lotta; C A Burris; Howard Federoff; William J Bowers
Extending the transposable payload limit of Sleeping Beauty (SB) using the Herpes Simplex Virus (HSV)/SB amplicon-vector platform.
Gene therapy 2010;17(3):424-31.
2009: Kelly L Sudol; Michael A Mastrangelo; Wade C Narrow; Maria E Frazer; Yona R Levites; todd golde; Howard Federoff; William J Bowers
Generating differentially targeted amyloid-beta specific intrabodies as a passive vaccination strategy for Alzheimer's disease.
Molecular therapy : the journal of the American Society of Gene Therapy 2009;17(12):2031-40.
2009: Michael A Mastrangelo; Kelly L Sudol; Wade C Narrow; William J Bowers
Interferon-{gamma} differentially affects Alzheimer's disease pathologies and induces neurogenesis in triple transgenic-AD mice.
The American journal of pathology 2009;175(5):2076-88.
2009: Keigan M Park; David I Yule; William J Bowers
Tumor necrosis factor-alpha-mediated regulation of the inositol 1,4,5-trisphosphate receptor promoter.
The Journal of biological chemistry 2009;284(40):27557-66.
2009: Massimo Fiandaca; Vanja Varenika; Jamie L Eberling; Tracy R McKnight; John Bringas; Phillip Pivirotto; Janine Beyer; Piotr Hadaczek; William J Bowers; John Park; Howard Federoff; John R Forsayeth; Krystof S Bankiewicz
Real-time MR imaging of adeno-associated viral vector delivery to the primate brain.
NeuroImage 2009;47 Suppl 2():T27-35.
2009: Yahui Grace Chiu; William J Bowers; Seung T Lim; Deborah A Ryan; Howard Federoff
Effects of herpes simplex virus amplicon transduction on murine dendritic cells.
Human gene therapy 2009;20(5):442-52.
2009: sandrine daubeuf; Divyendu Singh; Yaohong Tan; Hongiu Liu; Howard Federoff; William J Bowers; Khaled A Tolba
HSV ICP0 recruits USP7 to modulate TLR-mediated innate response.
Blood 2009;113(14):3264-75.
2009: Simona Bancos; Qingyu Cao; William J Bowers; I Nicholas Crispe
Dysfunctional memory CD8+ T cells after priming in the absence of the cell cycle regulator E2F4.
Cellular immunology 2009;257(1-2):44-54.
2009: Maya K Desai; Kelly L Sudol; Michelle C Janelsins; Michael A Mastrangelo; Maria E Frazer; William J Bowers
Triple-transgenic Alzheimer's disease mice exhibit region-specific abnormalities in brain myelination patterns prior to appearance of amyloid and tau pathology.
Glia 2009;57(1):54-65.
2008: Michelle C Janelsins; Michael A Mastrangelo; Keigan M Park; Kelly L Sudol; Wade C Narrow; Salvatore Oddo; Frank M LaFerla; Linda M Callahan; Howard Federoff; William J Bowers
Chronic neuron-specific tumor necrosis factor-alpha expression enhances the local inflammatory environment ultimately leading to neuronal death in 3xTg-AD mice.
The American journal of pathology 2008;173(6):1768-82.
2008: Keigan M Park; David I Yule; William J Bowers
Tumor necrosis factor-alpha potentiates intraneuronal Ca2+ signaling via regulation of the inositol 1,4,5-trisphosphate receptor.
The Journal of biological chemistry 2008;283(48):33069-79.
2008: Maria E Frazer; Jennifer E Hughes; Michael A Mastrangelo; Jennifer L Tibbens; Howard Federoff; William J Bowers
Reduced pathology and improved behavioral performance in Alzheimer's disease mice vaccinated with HSV amplicons expressing amyloid-beta and interleukin-4.
Molecular therapy : the journal of the American Society of Gene Therapy 2008;16(5):845-53.
2008: hovav nechushtan; Dien Pham; Yu Zhang; Daniel Morgensztern; Kyung H Yi; Seung-Uon Shin; Howard Federoff; William J Bowers; Khaled A Tolba; Joseph D Rosenblatt
Augmentation of anti-tumor responses of adoptively transferred CD8+T cells in the lymphopenic setting by HSV amplicon transduction.
Cancer immunology, immunotherapy : CII 2008;57(5):663-75.
2008: Clark A Burris; Suresh de Silva; Wade C Narrow; Ann E Casey; Louis T Lotta; Howard Federoff; William J Bowers
Hexamethylene bisacetamide leads to reduced helper virus-free HSV-1 amplicon expression titers via suppression of ICP0.
The journal of gene medicine 2008;10(2):152-64.
2008: Michael A Mastrangelo; William J Bowers
Detailed immunohistochemical characterization of temporal and spatial progression of Alzheimer's disease-related pathologies in male triple-transgenic mice.
BMC neuroscience 2008;9():81.
2007: Cindy M P Duke; Casey A Maguire; Michael C Keefer; Howard Federoff; William J Bowers; Stephen Dewhurst
HSV-1 amplicon vectors elicit polyfunctional T cell responses to HIV-1 Env, and strongly boost responses to an adenovirus prime.
Vaccine 2007;25(42):7410-21.
2007: Kyung H Yi; hovav nechushtan; William J Bowers; Gail R. Walker; Yu Zhang; Dien G Pham; Eckhard R Podack; Howard Federoff; Khaled A Tolba; Joseph D Rosenblatt
Adoptively transferred tumor-specific T cells stimulated ex vivo using herpes simplex virus amplicons encoding 4-1BBL persist in the host and show antitumor activity in vivo.
Cancer research 2007;67(20):10027-37.
2007: Mitra Azadniv; Kari Dugger; William J Bowers; Casey Weaver; I Nicholas Crispe
Imaging CD8+ T cell dynamics in vivo using a transgenic luciferase reporter.
International immunology 2007;19(10):1165-73.
2007: Elise B Peterson; Michael A Mastrangelo; Howard Federoff; William J Bowers
Neuronal specificity of HSV/sleeping beauty amplicon transduction in utero is driven primarily by tropism and cell type composition.
Molecular therapy : the journal of the American Society of Gene Therapy 2007;15(10):1848-55.
2007: Kathlyn Santos; Christine M Sanfilippo; Wade C Narrow; Ann E Casey; Sol Rodriguez-Colon; Michael P McDermott; Howard Federoff; William J Bowers; Stephen Dewhurst
Infectivity of herpes simplex virus type-1 (HSV-1) amplicon vectors in dendritic cells is determined by the helper virus strain used for packaging.
Journal of virological methods 2007;145(1):37-46.
2007: Caryl E Sortwell; William J Bowers; Scott E Counts; Mark R Pitzer; Matthew F Fleming; Susan McGuire; Kathleen A Maguire-Zeiss; Howard Federoff; Timothy J Collier
Effects of ex vivo transduction of mesencephalic reaggregates with bcl-2 on grafted dopamine neuron survival.
Brain research 2007;1134(1):33-44.
2007: Kathlyn Santos; Cindy M P Duke; Sol Rodriguez-Colon; Anthony Dakwar; Shongshan Fan; Michael C Keefer; Howard Federoff; john frelinger; William J Bowers; Stephen Dewhurst
Effect of promoter strength on protein expression and immunogenicity of an HSV-1 amplicon vector encoding HIV-1 Gag.
Vaccine 2007;25(9):1634-46.
2007: Kathlyn Santos; David A L Simon; Erin Conway; William J Bowers; Soumya Mitra; Thomas H Foster; Amit A Lugade; Edith M Lord; Howard Federoff; Stephen Dewhurst; john frelinger
Spatial and temporal expression of herpes simplex virus type 1 amplicon-encoded genes: implications for their use as immunization vectors.
Human gene therapy 2007;18(2):93-105.
2006: Marc W Halterman; Rita E Giuliano; William J Bowers; Howard Federoff
Improved HSV-1 amplicon packaging using virion host shutoff mutants lacking mRNAse activity.
The journal of gene medicine 2006;8(11):1320-8.
2006: Carolyn M Tyler; Charles A Wuertzer; William J Bowers; Howard Federoff
HSV amplicons: neuro applications.
Current gene therapy 2006;6(3):337-50.
2006: William J Bowers; Michael A Mastrangelo; Darlene F Howard; Hilary A Southerland; Kathleen A Maguire-Zeiss; Howard Federoff
Neuronal precursor-restricted transduction via in utero CNS gene delivery of a novel bipartite HSV amplicon/transposase hybrid vector.
Molecular therapy : the journal of the American Society of Gene Therapy 2006;13(3):580-8.
2006: Victor L Arvanian; William J Bowers; Aileen Anderson; Philip J Horner; Howard Federoff; Lorne Mendell
Combined delivery of neurotrophin-3 and NMDA receptors 2D subunit strengthens synaptic transmission in contused and staggered double hemisected spinal cord of neonatal rat.
Experimental neurology 2006;197(2):347-52.
2005: Maura Reinblatt; Richard H Pin; William J Bowers; Howard Federoff; Yuman Fong
Herpes simplex virus amplicon delivery of a hypoxia-inducible soluble vascular endothelial growth factor receptor (sFlk-1) inhibits angiogenesis and tumor growth in pancreatic adenocarcinoma.
Annals of surgical oncology 2005;12(12):1025-36.
2005: Howard Federoff; William J Bowers
Immune shaping and the development of Alzheimer's disease vaccines.
Science of aging knowledge environment : SAGE KE 2005;2005(46):pe35.
2005: Michelle C Janelsins; Michael A Mastrangelo; Salvatore Oddo; Frank M LaFerla; Howard Federoff; William J Bowers
Early correlation of microglial activation with enhanced tumor necrosis factor-alpha and monocyte chemoattractant protein-1 expression specifically within the entorhinal cortex of triple transgenic Alzheimer's disease mice.
Journal of neuroinflammation 2005;2():23.
2005: Thomas D Corso; German Torres; Christopher Goulah; Indrajit Roy; Angelo S Gambino; John Nayda; Timothy Buckley; Ewa K Stachowiak; Earl J Bergey; Haridas E Pudavar; Purnendu Dutta; David Bloom; William J Bowers; Michal K Stachowiak
Transfection of tyrosine kinase deleted FGF receptor-1 into rat brain substantia nigra reduces the number of tyrosine hydroxylase expressing neurons and decreases concentration levels of striatal dopamine.
Brain research. Molecular brain research 2005;139(2):361-6.
2005: Thomas D Corso; German Torres; Christopher Goulah; Indrajit Roy; Angelo S Gambino; John Nayda; Timothy Buckley; Ewa K Stachowiak; Earl J Bergey; Haridas E Pudavar; Purnendu Dutta; David Bloom; William J Bowers; Michal K Stachowiak
Assessment of viral and non-viral gene transfer into adult rat brains using HSV-1, calcium phosphate and PEI-based methods.
Folia morphologica 2005;64(3):130-44.
2005: William J Bowers; Michael A Mastrangelo; Hilary A Stanley; Ann E Casey; Lawrence Milo; Howard Federoff
HSV amplicon-mediated Abeta vaccination in Tg2576 mice: differential antigen-specific immune responses.
Neurobiology of aging 2005;26(4):393-407.
2005: Santhi Gorantla; Kathlyn Santos; Vakara Meyer; Stephen Dewhurst; William J Bowers; Howard Federoff; Howard E Gendelman; Larisa Poluektova
Human dendritic cells transduced with herpes simplex virus amplicons encoding human immunodeficiency virus type 1 (HIV-1) gp120 elicit adaptive immune responses from human cells engrafted into NOD/SCID mice and confer partial protection against HIV-1 challenge.
Journal of virology 2005;79(4):2124-32.
2004: Hongmin Wang; Seong-Woon Yu; David W Koh; Jasmine Lew; Carmen Coombs; William J Bowers; Howard Federoff; Guy G Poirier; Ted M Dawson; Valina Dawson
Apoptosis-inducing factor substitutes for caspase executioners in NMDA-triggered excitotoxic neuronal death.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(48):10963-73.
2004: Richard H Pin; Maura Reinblatt; William J Bowers; Howard Federoff; Yuman Fong
Herpes simplex virus amplicon delivery of a hypoxia-inducible angiogenic inhibitor blocks capillary formation in hepatocellular carcinoma.
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 2004;8(7):812-22; discussion 822-3.
2004: Victor L Arvanian; William J Bowers; Jeffrey C Petruska; Vladimir Motin; Honeyleen Manuzon; Wade C Narrow; Howard Federoff; Lorne Mendell
Viral delivery of NR2D subunits reduces Mg2+ block of NMDA receptor and restores NT-3-induced potentiation of AMPA-kainate responses in maturing rat motoneurons.
Journal of neurophysiology 2004;92(4):2394-404.
2003: Stephanos Kyrkanides; Jen nie H Miller; William J Bowers; Howard Federoff
Transcriptional and posttranslational regulation of Cre recombinase by RU486 as the basis for an enhanced inducible expression system.
Molecular therapy : the journal of the American Society of Gene Therapy 2003;8(5):790-5.
2003: Brandon K Harvey; Chen-Fu Chang; Yung-Hsiao Chiang; William J Bowers; Marisela Morales; Barry Hoffer; Yun Wang; Howard Federoff
HSV amplicon delivery of glial cell line-derived neurotrophic factor is neuroprotective against ischemic injury.
Experimental neurology 2003;183(1):47-55.
2003: Yan Zhang; Yanguo Hong; Younes Bounhar; Megan Blacker; Xavier Roucou; Omar Tounekti; Emily Vereker; William J Bowers; Howard Federoff; Cynthia G Goodyer; Andréa LeBlanc
p75 neurotrophin receptor protects primary cultures of human neurons against extracellular amyloid beta peptide cytotoxicity.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(19):7385-94.
2003: Xiuqing Wang; Rebecca D Wiley; Thomas G Evans; William J Bowers; Howard Federoff; Stephen Dewhurst
Cellular immune responses to helper-free HSV-1 amplicon particles encoding HIV-1 gp120 are enhanced by DNA priming.
Vaccine 2003;21(19-20):2288-97.
2003: William J Bowers; John A Olschowka; Howard Federoff
Immune responses to replication-defective HSV-1 type vectors within the CNS: implications for gene therapy.
Gene therapy 2003;10(11):941-5.
2003: John A Olschowka; William J Bowers; Sean D Hurley; Michael A Mastrangelo; Howard Federoff
Helper-free HSV-1 amplicons elicit a markedly less robust innate immune response in the CNS.
Molecular therapy : the journal of the American Society of Gene Therapy 2003;7(2):218-27.
2003: Jennifer E Snyder; William J Bowers; Alexandra M Livingstone; F Eun-Hyung Lee; Howard Federoff; Tim R Mosmann
Measuring the frequency of mouse and human cytotoxic T cells by the Lysispot assay: independent regulation of cytokine secretion and short-term killing.
Nature medicine 2003;9(2):231-5.
2002: Steven W Wang; Xiuqian Mu; William J Bowers; William H Klein
Retinal ganglion cell differentiation in cultured mouse retinal explants.
Methods (San Diego, Calif.) 2002;28(4):448-56.
2002: Khaled A Tolba; William J Bowers; Jacquelyn Muller; Vickie Housekneckt; Rita E Giuliano; Howard Federoff; Joseph D Rosenblatt
Herpes simplex virus (HSV) amplicon-mediated codelivery of secondary lymphoid tissue chemokine and CD40L results in augmented antitumor activity.
Cancer research 2002;62(22):6545-51.
2002: Khaled A Tolba; William J Bowers; David J Eling; Ann E Casey; Thomas Kipps; Howard Federoff; Joseph D Rosenblatt
HSV amplicon-mediated delivery of LIGHT enhances the antigen-presenting capacity of chronic lymphocytic leukemia.
Molecular therapy : the journal of the American Society of Gene Therapy 2002;6(4):455-63.
2002: Kathleen A Maguire-Zeiss; William J Bowers; Howard Federoff
Somatic mosaic approaches and the aging brain.
Neurobiology of aging 2002;23(5):977-84.
2002: William J Bowers; Howard Federoff
Amyloid immunotherapy-engendered CNS inflammation.
Neurobiology of aging 2002;23(5):675-6; discussion 683-4.
2002: Seong-Woon Yu; Hongmin Wang; Marc F Poitras; Carmen Coombs; William J Bowers; Howard Federoff; Guy G Poirier; Ted M Dawson; Valina Dawson
Mediation of poly(ADP-ribose) polymerase-1-dependent cell death by apoptosis-inducing factor.
Science (New York, N.Y.) 2002;297(5579):259-63.
2002: Ami Mankodi; Masanori P Takahashi; Hong Jiang; Carol L Beck; William J Bowers; Richard T Moxley; Stephen C Cannon; Charles A Thornton
Expanded CUG repeats trigger aberrant splicing of ClC-1 chloride channel pre-mRNA and hyperexcitability of skeletal muscle in myotonic dystrophy.
Molecular cell 2002;10(1):35-44.
2002: William J Bowers; Xiaowei Chen; Huang Guo; D Robert Frisina; Howard Federoff; Robert D Frisina
Neurotrophin-3 transduction attenuates cisplatin spiral ganglion neuron ototoxicity in the cochlea.
Molecular therapy : the journal of the American Society of Gene Therapy 2002;6(1):12-8.
2002: Eric R Detrait; William J Bowers; Marc W Halterman; Rita E Giuliano; Lisa Bennice; Howard Federoff; Eric K Richfield
Reporter gene transfer induces apoptosis in primary cortical neurons.
Molecular therapy : the journal of the American Society of Gene Therapy 2002;5(6):723-30.
2002: Peter K Hocknell; Rebecca D Wiley; Xiuqing Wang; Thomas G Evans; William J Bowers; Tomas Hanke; Howard Federoff; Stephen Dewhurst
Expression of human immunodeficiency virus type 1 gp120 from herpes simplex virus type 1-derived amplicons results in potent, specific, and durable cellular and humoral immune responses.
Journal of virology 2002;76(11):5565-80.
2002: Issam A Halaby; Sean P Lyden; Mark G Davies; Elisa Roztocil; Linda J Salamone; Andrew I Brooks; Richard M Green; Howard Federoff; William J Bowers
Glucocorticoid-regulated VEGF expression in ischemic skeletal muscle.
Molecular therapy : the journal of the American Society of Gene Therapy 2002;5(3):300-6.
2002: Steven W Wang; Xiuqian Mu; William J Bowers; Dong-Seob Kim; Daniel J Plas; Michael C Crair; Howard Federoff; Lin Gan; William H Klein
Brn3b/Brn3c double knockout mice reveal an unsuspected role for Brn3c in retinal ganglion cell axon outgrowth.
Development (Cambridge, England) 2002;129(2):467-77.
2001: Richard A Willis; William J Bowers; Michael J Turner; Terrence L Fisher; C Siddiq Abdul Alim; Darlene F Howard; Howard Federoff; Edith M Lord; john frelinger
Dendritic cells transduced with HSV-1 amplicons expressing prostate-specific antigen generate antitumor immunity in mice.
Human gene therapy 2001;12(15):1867-79.
2001: Kathleen A Maguire-Zeiss; William J Bowers; Howard Federoff
HSV vector-mediated gene delivery to the central nervous system.
Current opinion in molecular therapeutics 2001;3(5):482-90.
2001: Nurit Ballas; Elena Battaglioli; F Atouf; M E Andres; Josh Chenoweth; M E Anderson; C Burger; Mariko Moniwa; James Davie; William J Bowers; Howard Federoff; David W Rose; Michael G Rosenfeld; Paul Brehm; Gail Mandel
Regulation of neuronal traits by a novel transcriptional complex.
Neuron 2001;31(3):353-65.
2001: Khaled A Tolba; William J Bowers; Shannon P Hilchey; Marc W Halterman; Darlene F Howard; Rita E Giuliano; Howard Federoff; Joseph D Rosenblatt
Development of herpes simplex virus-1 amplicon-based immunotherapy for chronic lymphocytic leukemia.
Blood 2001;98(2):287-95.
2001: X Chen; Robert D Frisina; William J Bowers; D Robert Frisina; Howard Federoff
HSV amplicon-mediated neurotrophin-3 expression protects murine spiral ganglion neurons from cisplatin-induced damage.
Molecular therapy : the journal of the American Society of Gene Therapy 2001;3(6):958-63.
2001: Mandy Jackson; W Song; M Y Liu; Lin Jin; Margaret Dykes-Hoberg; Chien-liang Glenn Lin; William J Bowers; Howard Federoff; P C Sternweis; Jeffrey rothstein
Modulation of the neuronal glutamate transporter EAAT4 by two interacting proteins.
Nature 2001;410(6824):89-93.
2001: William J Bowers; Darlene F Howard; Andrew I Brooks; Marc W Halterman; Howard Federoff
Expression of vhs and VP16 during HSV-1 helper virus-free amplicon packaging enhances titers.
Gene therapy 2001;8(2):111-20.
2000: Andrew I Brooks; Deborah A Cory-Slechta; William J Bowers; S L Murg; Howard Federoff
Enhanced learning in mice parallels vector-mediated nerve growth factor expression in hippocampus.
Human gene therapy 2000;11(17):2341-52.
2000: William J Bowers; Darlene F Howard; Howard Federoff
Discordance between expression and genome transfer titering of HSV amplicon vectors: recommendation for standardized enumeration.
Molecular therapy : the journal of the American Society of Gene Therapy 2000;1(3):294-9.
1997: William J Bowers; Darlene F Howard; Howard Federoff
Gene therapeutic strategies for neuroprotection: implications for Parkinson's disease.
Experimental neurology 1997;144(1):58-68.