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Ashok Venkitaraman

Research Profile

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Duncan E Scott; Ashok R Venkitaraman; May Marsh; Tara Pukala; Chris Abell; Tom L Blundell; Matthias T Ehebauer; Marko Hyvönen
Using a fragment-based approach to target protein-protein interactions.
Robert Mahen; Pooja Sharma; Hiroyoshi Hattori; Anand D Jeyasekharan; Miyoung Lee; Ashok R Venkitaraman
A-type lamins maintain the positional stability of DNA damage repair foci in Mammalian nuclei.
Maiko Kurosawa; Eva-Maria Surmann; Vignesh Venkatraman; Ashok R Venkitaraman; Koichi Furukawa; Noboru Hashimoto; Anand D Jeyasekharan; Gene Kurosawa; Yoshikazu Kurosawa
Expression of LY6D is induced at the surface of MCF10A cells by X-ray irradiation.

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2013: Duncan E Scott; Ashok R Venkitaraman; May Marsh; Tara Pukala; Chris Abell; Tom L Blundell; Matthias T Ehebauer; Marko Hyvönen
Using a fragment-based approach to target protein-protein interactions.
Chembiochem : a European journal of chemical biology 2013;14(3):332-42.
2013: Robert Mahen; Pooja Sharma; Hiroyoshi Hattori; Anand D Jeyasekharan; Miyoung Lee; Ashok R Venkitaraman
A-type lamins maintain the positional stability of DNA damage repair foci in Mammalian nuclei.
PloS one 2013;8(5):e61893.
2012: Maiko Kurosawa; Eva-Maria Surmann; Vignesh Venkatraman; Ashok R Venkitaraman; Koichi Furukawa; Noboru Hashimoto; Anand D Jeyasekharan; Gene Kurosawa; Yoshikazu Kurosawa
Expression of LY6D is induced at the surface of MCF10A cells by X-ray irradiation.
The FEBS journal 2012;279(24):4479-91.
2012: Kieron M G O'Connell; Ashok R Venkitaraman; Henning S G Beckmann; Andreas Bender; Helen T Horsley; Luca Laraia; David R Spring
A two-directional strategy for the diversity-oriented synthesis of macrocyclic scaffolds.
Organic & biomolecular chemistry 2012;10(37):7545-51.
2012: Ko Sato; Ralph Schiess; Anna S Sedukhina; Elayanambi Sundaramoorthy ; Ruedi Aebersold; Nabieh Ayoub; Hiroyoshi Hattori; Anand D Jeyasekharan; Hiroyuki Nishikawa; Tomohiko Ohta; Eeson Rajendra; Haruka Wada; Ashok R Venkitaraman
A DNA-damage selective role for BRCA1 E3 ligase in claspin ubiquitylation, CHK1 activation, and DNA repair.
Current biology : CB 2012;22(18):1659-66.
2012: Emma Bolderson; Mark E Graham; Robert Mahen; Venkat Pisupati; Derek J Richard; Phillip J Robinson; Kienan I Savage; Ashok R Venkitaraman; Kum Kum Khanna
Kruppel-associated Box (KRAB)-associated co-repressor (KAP-1) Ser-473 phosphorylation regulates heterochromatin protein 1β (HP1-β) mobilization and DNA repair in heterochromatin.
The Journal of biological chemistry 2012;287(33):28122-31.
2012: Elizabeth C Frye; David G Hulcoop; Luca Laraia; David G Twigg; Ashok R Venkitaraman; Cornelius J O'Connor; Bryony Elbert; David R Spring
Palladium-catalysed cross-coupling of vinyldisiloxanes with benzylic and allylic halides and sulfonates.
Chemistry (Weinheim an der Bergstrasse, Germany) 2012;18(28):8774-9.
2012: P Russell; R C Bast; Mark S Carey; T Freeman; B T Hennessy; J Li; Ashok R Venkitaraman
Cyclin G1 regulates the outcome of taxane-induced mitotic checkpoint arrest.
Oncogene 2012;31(19):2450-60.
2012: Shaojun Zheng; Luca Laraia; Cornelius J O' Connor; David Sorrell; Yaw Sing Tan; Ashok R Venkitaraman; Wenjun Wu; Zhaochao Xu; David R Spring
Synthesis and biological profiling of tellimagrandin I and analogues reveals that the medium ring can significantly modulate biological activity.
Organic & biomolecular chemistry 2012;10(13):2590-3.
2012: Jaewon Min; Srihari Sampath; Ashok R Venkitaraman; Eun Shik Choi; Kwangwoo Hwang; Jimi Kim; Hyunsook Lee
The breast cancer susceptibility gene BRCA2 is required for the maintenance of telomere homeostasis.
The Journal of biological chemistry 2012;287(7):5091-101.
2012: Ashok R Venkitaraman
Beyond cancer genomics: after the end of the beginning.
Current opinion in genetics & development 2012;22(1):1-2.
2012: Liam D Cassidy; Ashok R Venkitaraman
Genome instability mechanisms and the structure of cancer genomes.
Current opinion in genetics & development 2012;22(1):10-3.
2012: Robert Mahen; Ashok R Venkitaraman
Pattern formation in centrosome assembly.
Current opinion in cell biology 2012;24(1):14-23.
2012: Anchal Chandra; Hernán E Grecco; Michael Hanzal-Bayer; Christian Hedberg; Shehab A Ismail; David Perera; Venkat Pisupati; Ferdinandos Skoulidis; Ashok R Venkitaraman; Alfred Wittinghofer; Liam Cassidy; Philippe I H Bastiaens
The GDI-like solubilizing factor PDEδ sustains the spatial organization and signalling of Ras family proteins.
Nature cell biology 2012;14(2):148-58.
2011: Ashok R Venkitaraman
Cancer: Let sleeping DNA lie.
Nature 2011;477(7363):169-70.
2011: M Lee; M J Daniels; M J Garnett; Ashok R Venkitaraman
A mitotic function for the high-mobility group protein HMG20b regulated by its interaction with the BRC repeats of the BRCA2 tumor suppressor.
Oncogene 2011;30(30):3360-9.
2011: Daniel J Cole; Bryn Hardwick; Grahame J McKenzie; Mike C Payne; Eeson Rajendra; Meredith Roberts-Thomson; Ashok R Venkitaraman; Chris-Kriton Skylaris
Interrogation of the protein-protein interactions between human BRCA2 BRC repeats and RAD51 reveals atomistic determinants of affinity.
PLoS computational biology 2011;7(7):e1002096.
2011: Robert Mahen; Anand D Jeyasekharan; Nicholas P Barry; Ashok R Venkitaraman
Continuous polo-like kinase 1 activity regulates diffusion to maintain centrosome self-organization during mitosis.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(22):9310-5.
2011: Ashok R Venkitaraman
Does metabolite deficiency mark oncogenic cell cycles?
Cell 2011;145(3):337-8.
2011: Paweł Śledź; Christopher J Stubbs; Steffen Lang; Yong-Qing Yang; Grahame J McKenzie; Ashok R Venkitaraman; Marko Hyvönen; Chris Abell
From crystal packing to molecular recognition: prediction and discovery of a binding site on the surface of polo-like kinase 1.
Angewandte Chemie (International ed. in English) 2011;50(17):4003-6.
2011: Hiroyoshi Hattori; Ferdinandos Skoulidis; Paul Russell; Ashok R Venkitaraman
Context dependence of checkpoint kinase 1 as a therapeutic target for pancreatic cancers deficient in the BRCA2 tumor suppressor.
Molecular cancer therapeutics 2011;10(4):670-8.
2011: Juan A Bernal; Ashok R Venkitaraman
A vertebrate N-end rule degron reveals that Orc6 is required in mitosis for daughter cell abscission.
The Journal of cell biology 2011;192(6):969-78.
2011: David J Huggins; Ashok R Venkitaraman; David R Spring
Rational methods for the selection of diverse screening compounds.
ACS chemical biology 2011;6(3):208-17.
2011: Keith I E McLuckie; Zoë A E Waller; Deborah A Sanders; David Alves; Raphaël Rodriguez; Jyotirmayee Dash; Grahame J McKenzie; Ashok R Venkitaraman; Shankar Balasubramanian
G-quadruplex-binding benzo[a]phenoxazines down-regulate c-KIT expression in human gastric carcinoma cells.
Journal of the American Chemical Society 2011;133(8):2658-63.
2011: Alessandro Esposito; Arjen N Bader; Simon C Schlachter; Dave J van den Heuvel; Gabriele S Kaminski Schierle; Ashok R Venkitaraman; Clemens F Kaminski; Hans C Gerritsen
Design and application of a confocal microscope for spectrally resolved anisotropy imaging.
Optics express 2011;19(3):2546-55.
2010: Anand D Jeyasekharan; Nabieh Ayoub; Robert Mahen; Jonas Ries; Alessandro Esposito; Eeson Rajendra; Hiroyoshi Hattori; Rajan P Kulkarni; Ashok R Venkitaraman
DNA damage regulates the mobility of Brca2 within the nucleoplasm of living cells.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(50):21937-42.
2010: Ferdinandos Skoulidis; Liam D Cassidy; Venkat Pisupati; Jon G Jonasson; Hordur Bjarnason; Jorunn E Eyfjord; Florian A Karreth; Michael Lim; Lorraine M Barber; Susan A Clatworthy; Susan E Davies; Kenneth P Olive; David A Tuveson; Ashok R Venkitaraman
Germline Brca2 heterozygosity promotes Kras(G12D) -driven carcinogenesis in a murine model of familial pancreatic cancer.
Cancer cell 2010;18(5):499-509.
2010: Ayaka Koike; Hiroyuki Nishikawa; Wenwen Wu; Yukinori Okada; Ashok R Venkitaraman; Tomohiko Ohta
Recruitment of phosphorylated NPM1 to sites of DNA damage through RNF8-dependent ubiquitin conjugates.
Cancer research 2010;70(17):6746-56.
2010: Wenwen Wu; Ko Sato; Ayaka Koike; Hiroyuki Nishikawa; Hirotaka Koizumi; Ashok R Venkitaraman; Tomohiko Ohta
HERC2 is an E3 ligase that targets BRCA1 for degradation.
Cancer research 2010;70(15):6384-92.
2010: Ko Sato; Tomohiko Ohta; Ashok R Venkitaraman
A mitotic role for the DNA damage-responsive CHK2 kinase.
Nature cell biology 2010;12(5):424-5.
2010: Ashok R Venkitaraman
Modifying chromatin architecture during the response to DNA breakage.
Critical reviews in biochemistry and molecular biology 2010;45(1):2-13.
2010: David J Huggins; Grahame J McKenzie; Daniel D Robinson; Ana J Narváez; Bryn Hardwick; Meredith Roberts-Thomson; Ashok R Venkitaraman; Guy H Grant; Mike C Payne
Computational analysis of phosphopeptide binding to the polo-box domain of the mitotic kinase PLK1 using molecular dynamics simulation.
PLoS computational biology 2010;6(8):.
2010: Eeson Rajendra; Ashok R Venkitaraman
Two modules in the BRC repeats of BRCA2 mediate structural and functional interactions with the RAD51 recombinase.
Nucleic acids research 2010;38(1):82-96.
2009: Mathew J Garnett; Jörg Mansfeld; Colin Godwin; Takahiro Matsusaka; Jiahua Wu; Paul Russell; Jonathon Pines; Ashok R Venkitaraman
UBE2S elongates ubiquitin chains on APC/C substrates to promote mitotic exit.
Nature cell biology 2009;11(11):1363-9.
2009: Nabieh Ayoub; Anand D Jeyasekharan; Ashok R Venkitaraman
Mobilization and recruitment of HP1: a bimodal response to DNA breakage.
Cell cycle (Georgetown, Tex.) 2009;8(18):2945-50.
2009: Mahmud K K Shivji; Shreyas R Mukund; Eeson Rajendra; Shaoxia Chen; Judith M Short; Jane Savill; David Klenerman; Ashok R Venkitaraman
The BRC repeats of human BRCA2 differentially regulate RAD51 binding on single- versus double-stranded DNA to stimulate strand exchange.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(32):13254-9.
2009: Ashok R Venkitaraman
Targeting the molecular defect in BRCA-deficient tumors for cancer therapy.
Cancer cell 2009;16(2):89-90.
2009: Nabieh Ayoub; Eeson Rajendra; Xinyi Su; Anand D Jeyasekharan; Robert Mahen; Ashok R Venkitaraman
The carboxyl terminus of Brca2 links the disassembly of Rad51 complexes to mitotic entry.
Current biology : CB 2009;19(13):1075-85.
2009: Nabieh Ayoub; Anand D Jeyasekharan; Juan A Bernal; Ashok R Venkitaraman
Paving the way for H2AX phosphorylation: chromatin changes in the DNA damage response.
Cell cycle (Georgetown, Tex.) 2009;8(10):1494-500.
2009: Hiroko Shimizu; Milena Popova; Fabrice Fleury; Masahiko Kobayashi; Naoyuki Hayashi; Isao Sakane; Hitoshi Kurumizaka; Ashok R Venkitaraman; Masayuki Takahashi; Ken-ichi Yamamoto
c-ABL tyrosine kinase stabilizes RAD51 chromatin association.
Biochemical and biophysical research communications 2009;382(2):286-91.
2009: Aura Carreira; Jovencio Hilario; Ichiro Amitani; Ronald J Baskin; Mahmud K K Shivji; Ashok R Venkitaraman; Stephen C Kowalczykowski
The BRC repeats of BRCA2 modulate the DNA-binding selectivity of RAD51.
Cell 2009;136(6):1032-43.
2009: Victor Martin Bolanos-Garcia; Tomomi Kiyomitsu; Sheena D'Arcy; Dimitri Y Chirgadze; J Günter Grossmann; Dijana Matak Vinkovic; Ashok R Venkitaraman; Mitsuhiro Yanagida; Carol V Robinson; Tom L Blundell
The crystal structure of the N-terminal region of BUB1 provides insight into the mechanism of BUB1 recruitment to kinetochores.
Structure (London, England : 1993) 2009;17(1):105-16.
2009: Ashok R Venkitaraman
Linking the cellular functions of BRCA genes to cancer pathogenesis and treatment.
Annual review of pathology 2009;4():461-87.
2008: Xinyi Su; Juan A Bernal; Ashok R Venkitaraman
Cell-cycle coordination between DNA replication and recombination revealed by a vertebrate N-end rule degron-Rad51.
Nature structural & molecular biology 2008;15(10):1049-58.
2008: Nabieh Ayoub; Anand D Jeyasekharan; Juan A Bernal; Ashok R Venkitaraman
HP1-beta mobilization promotes chromatin changes that initiate the DNA damage response.
Nature 2008;453(7195):682-6.
2007: Ashok R Venkitaraman
Chromosomal instability in cancer: causality and interdependence.
Cell cycle (Georgetown, Tex.) 2007;6(19):2341-3.
2007: DM Winder; Mark R Pett; N Foster; Mahmud K K Shivji; M Trent Herdman; Margaret A Stanley; Ashok R Venkitaraman; Nicholas Coleman
An increase in DNA double-strand breaks, induced by Ku70 depletion, is associated with human papillomavirus 16 episome loss and de novo viral integration events.
The Journal of pathology 2007;213(1):27-34.
2006: Lucy Heady; Marivi Fernandez-Serra; Ricardo L Mancera; Sian Joyce; Ashok R Venkitaraman; Emilio Artacho; Chris-Kriton Skylaris; Lucio Colombi Ciacchi; Mike C Payne
Novel structural features of CDK inhibition revealed by an ab initio computational method combined with dynamic simulations.
Journal of medicinal chemistry 2006;49(17):5141-53.
2006: Himesh Fernando; Anthony P Reszka; Julian Huppert; Sylvain Ladame; Sarah Rankin; Ashok R Venkitaraman; Stephen Neidle; Shankar Balasubramanian
A conserved quadruplex motif located in a transcription activation site of the human c-kit oncogene.
Biochemistry 2006;45(25):7854-60.
2006: Mahmud K K Shivji; Owen Richard Davies; Jane M Savill; Debbie L Bates; Luca Pellegrini; Ashok R Venkitaraman
A region of human BRCA2 containing multiple BRC repeats promotes RAD51-mediated strand exchange.
Nucleic acids research 2006;34(14):4000-11.
2005: Victor Martin Bolanos-Garcia; Sylvie Beaufils; Anne Renault; J Günter Grossmann; Suzanne C Brewerton; M Lee; Ashok R Venkitaraman; Tom L Blundell
The conserved N-terminal region of the mitotic checkpoint protein BUBR1: a putative TPR motif of high surface activity.
Biophysical journal 2005;89(4):2640-9.
2005: Nobuko Matsushita; Hiroyuki Kitao; Masamichi Ishiai; Naoki Nagashima; Seiki Hirano; Katsuya Okawa; Tomohiko Ohta; David S Yu; Peter J McHugh; Ian D Hickson; Ashok R Venkitaraman; Hitoshi Kurumizaka; Minoru Takata
A FancD2-monoubiquitin fusion reveals hidden functions of Fanconi anemia core complex in DNA repair.
Molecular cell 2005;19(6):841-7.
2005: Mahesh N Sangrithi; Juan A Bernal; Mark Madine; Anna Philpott; Joon Lee; William G Dunphy; Ashok R Venkitaraman
Initiation of DNA replication requires the RECQL4 protein mutated in Rothmund-Thomson syndrome.
Cell 2005;121(6):887-98.
2005: Ashok R Venkitaraman
Medicine: aborting the birth of cancer.
Nature 2005;434(7035):829-30.
2005: Ashok R Venkitaraman
DUBing down a tumour suppressor.
Nature cell biology 2005;7(4):332-3.
2004: Matthew J Daniels; Alexander Marson; Ashok R Venkitaraman
PML bodies control the nuclear dynamics and function of the CHFR mitotic checkpoint protein.
Nature structural & molecular biology 2004;11(11):1114-21.
2004: Matthew J Daniels; Yunmei Wang; Miyoung Lee; Ashok R Venkitaraman
Abnormal cytokinesis in cells deficient in the breast cancer susceptibility protein BRCA2.
Science (New York, N.Y.) 2004;306(5697):876-9.
2004: Mahmud K K Shivji; Ashok R Venkitaraman
DNA recombination, chromosomal stability and carcinogenesis: insights into the role of BRCA2.
DNA repair 2004;3(8-9):835-43.
2004: Ashok R Venkitaraman
Preface: chromosomal instability and breast cancer pathogenesis.
Journal of mammary gland biology and neoplasia 2004;9(3):217-20.
2004: Luca Pellegrini; Ashok R Venkitaraman
Emerging functions of BRCA2 in DNA recombination.
Trends in biochemical sciences 2004;29(6):310-6.
2004: Ashok R Venkitaraman
Tracing the network connecting BRCA and Fanconi anaemia proteins.
Nature reviews. Cancer 2004;4(4):266-76.
2004: MiYoung Lee; Matthew J Daniels; Ashok R Venkitaraman
Phosphorylation of BRCA2 by the Polo-like kinase Plk1 is regulated by DNA damage and mitotic progression.
Oncogene 2004;23(4):865-72.
2003: Mikhail Lomonosov; Shubha Anand; Mahesh Sangrithi; Rachel Davies; Ashok R Venkitaraman
Stabilization of stalled DNA replication forks by the BRCA2 breast cancer susceptibility protein.
Genes & development 2003;17(24):3017-22.
2003: Luke Hughes-Davies; David Huntsman; Margarida Ruas; François Fuks; Jacqueline Bye; Suet-Feung Chin; Jonathon Milner; Lindsay A Brown; Forrest Hsu; Blake Gilks; Torsten Nielsen; Michael Schulzer; Stephen Chia; Joseph Ragaz; Anthony Cahn; Lori Linger; Hilal Ozdag; Elena Cattaneo; Ekaterina S. Jordanova; Edward Schuuring; David S Yu; Ashok R Venkitaraman; Bruce A J Ponder; Aidan Doherty; Samuel A J R Aparicio; David Bentley; Charles Theillet; Chris P Ponting; Carlos Caldas; Tony Kouzarides
EMSY links the BRCA2 pathway to sporadic breast and ovarian cancer.
Cell 2003;115(5):523-35.
2003: David S Yu; Eiichiro Sonoda; Shunichi Takeda; Christopher L-H Huang; Luca Pellegrini; Tom L Blundell; Ashok R Venkitaraman
Dynamic control of Rad51 recombinase by self-association and interaction with BRCA2.
Molecular cell 2003;12(4):1029-41.
2003: Thomas Lo; Luca Pellegrini; Ashok R Venkitaraman; Tom L Blundell
Sequence fingerprints in BRCA2 and RAD51: implications for DNA repair and cancer.
DNA repair 2003;2(9):1015-28.
2003: David S Shin; Luca Pellegrini; Douglas S Daniels; Biana Yelent; Lisa Craig; Debbie Bates; David S Yu; Mahmud K K Shivji; Chiharu Hitomi; Andrew S Arvai; Niels Volkmann; Hiro Tsuruta; Tom L Blundell; Ashok R Venkitaraman; John A Tainer
Full-length archaeal Rad51 structure and mutants: mechanisms for RAD51 assembly and control by BRCA2.
The EMBO journal 2003;22(17):4566-76.
2003: Suresh Logarajah; Patricia Hunter; Matthew Kraman; Dawn Steele; Sunil Lakhani; Lynda Bobrow; Ashok R Venkitaraman; Simon Wagner
BCL-6 is expressed in breast cancer and prevents mammary epithelial differentiation.
Oncogene 2003;22(36):5572-8.
2003: Ashok R Venkitaraman
A growing network of cancer-susceptibility genes.
The New England journal of medicine 2003;348(19):1917-9.
2003: Shubha Anand; Sue Penrhyn-Lowe; Ashok R Venkitaraman
AURORA-A amplification overrides the mitotic spindle assembly checkpoint, inducing resistance to Taxol.
Cancer cell 2003;3(1):51-62.
2002: Luca Pellegrini; David S Yu; Thomas Lo; Shubha Anand; MiYoung Lee; Tom L Blundell; Ashok R Venkitaraman
Insights into DNA recombination from the structure of a RAD51-BRCA2 complex.
Nature 2002;420(6913):287-93.
2002: Ashok R Venkitaraman
Connecting Fanconi's anaemia to breast cancer predisposition.
Lancet 2002;360(9343):1344-5.
2002: Ashok R Venkitaraman
Cancer susceptibility and the functions of BRCA1 and BRCA2.
Cell 2002;108(2):171-82.
2001: Ashok R Venkitaraman
Functions of BRCA1 and BRCA2 in the biological response to DNA damage.
Journal of cell science 2001;114(Pt 20):3591-8.
2001: Ashok R Venkitaraman
Chromosome stability, DNA recombination and the BRCA2 tumour suppressor.
Current opinion in cell biology 2001;13(3):338-43.
2000: VP Yu; M Koehler; C Steinlein; M Schmid; Leslyn Hanakahi; Alain van Gool; Stephen C West; Ashok R Venkitaraman
Gross chromosomal rearrangements and genetic exchange between nonhomologous chromosomes following BRCA2 inactivation.
Genes & development 2000;14(11):1400-6.
2000: Ashok R Venkitaraman
The breast cancer susceptibility gene, BRCA2: at the crossroads between DNA replication and recombination?
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2000;355(1394):191-8.
2000: F M Smart; Ashok R Venkitaraman
Inhibition of interleukin 7 receptor signaling by antigen receptor assembly.
The Journal of experimental medicine 2000;191(4):737-42.
2000: Ashok R Venkitaraman
Chromosomal instability and cancer predisposition: insights from studies on the breast cancer susceptibility gene, BRCA2.
Cold Spring Harbor symposia on quantitative biology 2000;65():567-72.
1999: Ashok R Venkitaraman
Breast cancer genes and DNA repair.
Science (New York, N.Y.) 1999;286(5442):1100-2.
1999: H Lee; A H Trainer; LS Friedman; FC Thistlethwaite; Martin J Evans; Bruce A J Ponder; Ashok R Venkitaraman
Mitotic checkpoint inactivation fosters transformation in cells lacking the breast cancer susceptibility gene, Brca2.
Molecular cell 1999;4(1):1-10.
1998: LS Friedman; FC Thistlethwaite; Ketan J Patel; VP Yu; H Lee; Ashok R Venkitaraman; K J Abel; Mark B L Carlton; S M Hunter; William H Colledge; Martin J Evans; Bruce A J Ponder
Thymic lymphomas in mice with a truncating mutation in Brca2.
Cancer research 1998;58(7):1338-43.
1998: A E Corcoran; A Riddell; D Krooshoop; Ashok R Venkitaraman
Impaired immunoglobulin gene rearrangement in mice lacking the IL-7 receptor.
Nature 1998;391(6670):904-7.
1998: Ketan J Patel; VP Yu; H Lee; A Corcoran; FC Thistlethwaite; Martin J Evans; William H Colledge; LS Friedman; Bruce A J Ponder; Ashok R Venkitaraman
Involvement of Brca2 in DNA repair.
Molecular cell 1998;1(3):347-57.
1996: A E Corcoran; F M Smart; Rachel Carol; T Crompton; M J Owen; Ashok R Venkitaraman
The interleukin-7 receptor alpha chain transmits distinct signals for proliferation and differentiation during B lymphopoiesis.
The EMBO journal 1996;15(8):1924-32.
1994: Ashok R Venkitaraman; Rachel Carol
Interleukin-7 induces the association of phosphatidylinositol 3-kinase with the alpha chain of the interleukin-7 receptor.
European journal of immunology 1994;24(9):2168-74.
1993: Gareth T Williams; P Dariavach; Ashok R Venkitaraman; D J Gilmore; Michael S Neuberger
Membrane immunoglobulin without sheath or anchor.
Molecular immunology 1993;30(16):1427-32.
1992: Ashok R Venkitaraman; Rachel Carol
Interleukin 7 receptor functions by recruiting the tyrosine kinase p59fyn through a segment of its cytoplasmic tail.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(24):12083-7.
1992: Ashok R Venkitaraman
Light chain surrogacy.
Current biology : CB 1992;2(10):559-61.
1991: Ashok R Venkitaraman; Gareth T Williams; P Dariavach; Michael S Neuberger
The B-cell antigen receptor of the five immunoglobulin classes.
Nature 1991;352(6338):777-81.
1990: Gareth T Williams; Ashok R Venkitaraman; D J Gilmore; Michael S Neuberger
The sequence of the mu transmembrane segment determines the tissue specificity of the transport of immunoglobulin M to the cell surface.
The Journal of experimental medicine 1990;171(3):947-52.
1989: Ashok R Venkitaraman
Use of modified T7 DNA polymerase (sequenase version 2.0) for oligonucleotide site-directed mutagenesis.
Nucleic acids research 1989;17(8):3314.