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Ashok Venkitaraman
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Research Profile (preview)
Chemicals & Drugs
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Phenomena
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Network (preview)
6
Blundell, Tom
6
Shivji, Mahmud
6
Pellegrini, Luca
4
Ponder, Bruce
3
Daniels, Matthew
3
Lee, H
3
Williams, Gareth
3
Thistlethwaite, FC
3
Neuberger, Michael
3
Evans, Martin
3
Friedman, LS
3
Anand, Shubha
3
Yu, David
3
Yu, VP
2
Bolanos-Garcia, Victor Martin
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Publications
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Geonetwork of Ashok Venkitaraman (preview)
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All Publications
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2009: Garnett Mathew J; Mansfeld Jörg; Godwin Colin; Matsusaka Takahiro; Wu Jiahua; Russell Paul; Pines Jonathon; Venkitaraman Ashok R
UBE2S elongates ubiquitin chains on APC/C substrates to promote mitotic exit.
Nature cell biology 2009;11(11):1363-9.
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2009: Ayoub Nabieh; Jeyasekharan Anand D; Venkitaraman Ashok R
Mobilization and recruitment of HP1: a bimodal response to DNA breakage.
Cell cycle (Georgetown, Tex.) 2009;8(18):2945-50.
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2009: Venkitaraman Ashok R
Targeting the molecular defect in BRCA-deficient tumors for cancer therapy.
Cancer cell 2009;16(2):89-90.
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2009: Shivji Mahmud K K; Mukund Shreyas R; Rajendra Eeson; Chen Shaoxia; Short Judith M; Savill Jane; Klenerman David; Venkitaraman Ashok R
The BRC repeats of human BRCA2 differentially regulate RAD51 binding on single- versus double-stranded DNA to stimulate strand exchange.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(32):13254-9.
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2009: Ayoub Nabieh; Rajendra Eeson; Su Xinyi; Jeyasekharan Anand D; Mahen Robert; Venkitaraman Ashok R
The carboxyl terminus of Brca2 links the disassembly of Rad51 complexes to mitotic entry.
Current biology : CB 2009;19(13):1075-85.
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2009: Ayoub Nabieh; Jeyasekharan Anand D; Bernal Juan A; Venkitaraman Ashok R
Paving the way for H2AX phosphorylation: chromatin changes in the DNA damage response.
Cell cycle (Georgetown, Tex.) 2009;8(10):1494-500.
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2009: Shimizu Hiroko; Popova Milena; Fleury Fabrice; Kobayashi Masahiko; Hayashi Naoyuki; Sakane Isao; Kurumizaka Hitoshi; Venkitaraman Ashok R; Takahashi Masayuki; Yamamoto Ken-ichi
c-ABL tyrosine kinase stabilizes RAD51 chromatin association.
Biochemical and biophysical research communications 2009;382(2):286-91.
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2009: Carreira Aura; Hilario Jovencio; Amitani Ichiro; Baskin Ronald J; Shivji Mahmud K K; Venkitaraman Ashok R; Kowalczykowski Stephen C
The BRC repeats of BRCA2 modulate the DNA-binding selectivity of RAD51.
Cell 2009;136(6):1032-43.
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2009: Bolanos-Garcia Victor M; Kiyomitsu Tomomi; D'Arcy Sheena; Chirgadze Dimitri Y; Grossmann J Günter; Matak-Vinkovic Dijana; Venkitaraman Ashok R; Yanagida Mitsuhiro; Robinson Carol V; Blundell Tom L
The crystal structure of the N-terminal region of BUB1 provides insight into the mechanism of BUB1 recruitment to kinetochores.
Structure (London, England : 1993) 2009;17(1):105-16.
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2009: Venkitaraman Ashok R
Linking the cellular functions of BRCA genes to cancer pathogenesis and treatment.
Annual review of pathology 2009;4():461-87.
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2008: Su Xinyi; Bernal Juan A; Venkitaraman Ashok R
Cell-cycle coordination between DNA replication and recombination revealed by a vertebrate N-end rule degron-Rad51.
Nature structural & molecular biology 2008;15(10):1049-58.
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2008: Ayoub Nabieh; Jeyasekharan Anand D; Bernal Juan A; Venkitaraman Ashok R
HP1-beta mobilization promotes chromatin changes that initiate the DNA damage response.
Nature 2008;453(7195):682-6.
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2007: Venkitaraman Ashok R
Chromosomal instability in cancer: causality and interdependence.
Cell cycle (Georgetown, Tex.) 2007;6(19):2341-3.
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2007: Winder D M; Pett M R; Foster N; Shivji M K K; Herdman M T; Stanley M A; Venkitaraman A R; Coleman N
An increase in DNA double-strand breaks, induced by Ku70 depletion, is associated with human papillomavirus 16 episome loss and de novo viral integration events.
The Journal of pathology 2007;213(1):27-34.
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2006: Heady Lucy; Fernandez-Serra Marivi; Mancera Ricardo L; Joyce Sian; Venkitaraman Ashok R; Artacho Emilio; Skylaris Chris-Kriton; Ciacchi Lucio Colombi; Payne Mike C
Novel structural features of CDK inhibition revealed by an ab initio computational method combined with dynamic simulations.
Journal of medicinal chemistry 2006;49(17):5141-53.
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2006: Fernando Himesh; Reszka Anthony P; Huppert Julian; Ladame Sylvain; Rankin Sarah; Venkitaraman Ashok R; Neidle Stephen; Balasubramanian Shankar
A conserved quadruplex motif located in a transcription activation site of the human c-kit oncogene.
Biochemistry 2006;45(25):7854-60.
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2006: Shivji Mahmud K K; Davies Owen R; Savill Jane M; Bates Debbie L; Pellegrini Luca; Venkitaraman Ashok R
A region of human BRCA2 containing multiple BRC repeats promotes RAD51-mediated strand exchange.
Nucleic acids research 2006;34(14):4000-11.
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2005: Bolanos-Garcia V M; Beaufils S; Renault A; Grossmann J G; Brewerton S; Lee M; Venkitaraman A; Blundell T L
The conserved N-terminal region of the mitotic checkpoint protein BUBR1: a putative TPR motif of high surface activity.
Biophysical journal 2005;89(4):2640-9.
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2005: Matsushita Nobuko; Kitao Hiroyuki; Ishiai Masamichi; Nagashima Naoki; Hirano Seiki; Okawa Katsuya; Ohta Tomohiko; Yu David S; McHugh Peter J; Hickson Ian D; Venkitaraman Ashok R; Kurumizaka Hitoshi; Takata Minoru
A FancD2-monoubiquitin fusion reveals hidden functions of Fanconi anemia core complex in DNA repair.
Molecular cell 2005;19(6):841-7.
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2005: Sangrithi Mahesh N; Bernal Juan A; Madine Mark; Philpott Anna; Lee Joon; Dunphy William G; Venkitaraman Ashok R
Initiation of DNA replication requires the RECQL4 protein mutated in Rothmund-Thomson syndrome.
Cell 2005;121(6):887-98.
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2005: Venkitaraman Ashok R
Medicine: aborting the birth of cancer.
Nature 2005;434(7035):829-30.
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2005: Venkitaraman Ashok R
DUBing down a tumour suppressor.
Nature cell biology 2005;7(4):332-3.
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2004: Daniels Matthew J; Marson Alexander; Venkitaraman Ashok R
PML bodies control the nuclear dynamics and function of the CHFR mitotic checkpoint protein.
Nature structural & molecular biology 2004;11(11):1114-21.
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2004: Daniels Matthew J; Wang Yunmei; Lee Miyoung; Venkitaraman Ashok R
Abnormal cytokinesis in cells deficient in the breast cancer susceptibility protein BRCA2.
Science (New York, N.Y.) 2004;306(5697):876-9.
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2004: Shivji Mahmud K K; Venkitaraman Ashok R
DNA recombination, chromosomal stability and carcinogenesis: insights into the role of BRCA2.
DNA repair 2004;3(8-9):835-43.
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2004: Venkitaraman Ashok R
Preface: chromosomal instability and breast cancer pathogenesis.
Journal of mammary gland biology and neoplasia 2004;9(3):217-20.
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2004: Pellegrini Luca; Venkitaraman Ashok
Emerging functions of BRCA2 in DNA recombination.
Trends in biochemical sciences 2004;29(6):310-6.
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2004: Venkitaraman Ashok R
Tracing the network connecting BRCA and Fanconi anaemia proteins.
Nature reviews. Cancer 2004;4(4):266-76.
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2004: Lee MiYoung; Daniels Matthew J; Venkitaraman Ashok R
Phosphorylation of BRCA2 by the Polo-like kinase Plk1 is regulated by DNA damage and mitotic progression.
Oncogene 2004;23(4):865-72.
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2003: Lomonosov Mikhail; Anand Shubha; Sangrithi Mahesh; Davies Rachel; Venkitaraman Ashok R
Stabilization of stalled DNA replication forks by the BRCA2 breast cancer susceptibility protein.
Genes & development 2003;17(24):3017-22.
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2003: Hughes-Davies Luke; Huntsman David; Ruas Margarida; Fuks Francois; Bye Jacqueline; Chin Suet-Feung; Milner Jonathon; Brown Lindsay A; Hsu Forrest; Gilks Blake; Nielsen Torsten; Schulzer Michael; Chia Stephen; Ragaz Joseph; Cahn Anthony; Linger Lori; Ozdag Hilal; Cattaneo Elena; Jordanova E S; Schuuring Edward; Yu David S; Venkitaraman Ashok; Ponder Bruce; Doherty Aidan; Aparicio Samuel; Bentley David; Theillet Charles; Ponting Chris P; Caldas Carlos; Kouzarides Tony
EMSY links the BRCA2 pathway to sporadic breast and ovarian cancer.
Cell 2003;115(5):523-35.
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2003: Yu David S; Sonoda Eiichiro; Takeda Shunichi; Huang Christopher L H; Pellegrini Luca; Blundell Tom L; Venkitaraman Ashok R
Dynamic control of Rad51 recombinase by self-association and interaction with BRCA2.
Molecular cell 2003;12(4):1029-41.
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2003: Lo Thomas; Pellegrini Luca; Venkitaraman Ashok R; Blundell Tom L
Sequence fingerprints in BRCA2 and RAD51: implications for DNA repair and cancer.
DNA repair 2003;2(9):1015-28.
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2003: Shin David S; Pellegrini Luca; Daniels Douglas S; Yelent Biana; Craig Lisa; Bates Debbie; Yu David S; Shivji Mahmud K; Hitomi Chiharu; Arvai Andrew S; Volkmann Niels; Tsuruta Hiro; Blundell Tom L; Venkitaraman Ashok R; Tainer John A
Full-length archaeal Rad51 structure and mutants: mechanisms for RAD51 assembly and control by BRCA2.
The EMBO journal 2003;22(17):4566-76.
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2003: Logarajah Suresh; Hunter Patricia; Kraman Matthew; Steele Dawn; Lakhani Sunil; Bobrow Lynda; Venkitaraman Ashok; Wagner Simon
BCL-6 is expressed in breast cancer and prevents mammary epithelial differentiation.
Oncogene 2003;22(36):5572-8.
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2003: Venkitaraman Ashok R
A growing network of cancer-susceptibility genes.
The New England journal of medicine 2003;348(19):1917-9.
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2003: Anand Shubha; Penrhyn-Lowe Sue; Venkitaraman Ashok R
AURORA-A amplification overrides the mitotic spindle assembly checkpoint, inducing resistance to Taxol.
Cancer cell 2003;3(1):51-62.
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2002: Pellegrini Luca; Yu David S; Lo Thomas; Anand Shubha; Lee MiYoung; Blundell Tom L; Venkitaraman Ashok R
Insights into DNA recombination from the structure of a RAD51-BRCA2 complex.
Nature 2002;420(6913):287-93.
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2002: Venkitaraman Ashok R
Connecting Fanconi's anaemia to breast cancer predisposition.
Lancet 2002;360(9343):1344-5.
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2002: Venkitaraman Ashok R
Cancer susceptibility and the functions of BRCA1 and BRCA2.
Cell 2002;108(2):171-82.
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2001: Venkitaraman A R
Functions of BRCA1 and BRCA2 in the biological response to DNA damage.
Journal of cell science 2001;114(Pt 20):3591-8.
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2001: Venkitaraman A R
Chromosome stability, DNA recombination and the BRCA2 tumour suppressor.
Current opinion in cell biology 2001;13(3):338-43.
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2000: Yu V P; Koehler M; Steinlein C; Schmid M; Hanakahi L A; van Gool A J; West S C; Venkitaraman A R
Gross chromosomal rearrangements and genetic exchange between nonhomologous chromosomes following BRCA2 inactivation.
Genes & development 2000;14(11):1400-6.
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2000: Venkitaraman A R
The breast cancer susceptibility gene, BRCA2: at the crossroads between DNA replication and recombination?
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2000;355(1394):191-8.
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2000: Smart F M; Venkitaraman A R
Inhibition of interleukin 7 receptor signaling by antigen receptor assembly.
The Journal of experimental medicine 2000;191(4):737-42.
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2000: Venkitaraman A R
Chromosomal instability and cancer predisposition: insights from studies on the breast cancer susceptibility gene, BRCA2.
Cold Spring Harbor symposia on quantitative biology 2000;65():567-72.
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1999: Venkitaraman A R
Breast cancer genes and DNA repair.
Science (New York, N.Y.) 1999;286(5442):1100-2.
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1999: Lee H; Trainer A H; Friedman L S; Thistlethwaite F C; Evans M J; Ponder B A; Venkitaraman A R
Mitotic checkpoint inactivation fosters transformation in cells lacking the breast cancer susceptibility gene, Brca2.
Molecular cell 1999;4(1):1-10.
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1998: Friedman L S; Thistlethwaite F C; Patel K J; Yu V P; Lee H; Venkitaraman A R; Abel K J; Carlton M B; Hunter S M; Colledge W H; Evans M J; Ponder B A
Thymic lymphomas in mice with a truncating mutation in Brca2.
Cancer research 1998;58(7):1338-43.
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1998: Patel K J; Yu V P; Lee H; Corcoran A; Thistlethwaite F C; Evans M J; Colledge W H; Friedman L S; Ponder B A; Venkitaraman A R
Involvement of Brca2 in DNA repair.
Molecular cell 1998;1(3):347-57.
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1998: Corcoran A E; Riddell A; Krooshoop D; Venkitaraman A R
Impaired immunoglobulin gene rearrangement in mice lacking the IL-7 receptor.
Nature 1998;391(6670):904-7.
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1996: Corcoran A E; Smart F M; Cowling R J; Crompton T; Owen M J; Venkitaraman A R
The interleukin-7 receptor alpha chain transmits distinct signals for proliferation and differentiation during B lymphopoiesis.
The EMBO journal 1996;15(8):1924-32.
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1994: Venkitaraman A R; Cowling R J
Interleukin-7 induces the association of phosphatidylinositol 3-kinase with the alpha chain of the interleukin-7 receptor.
European journal of immunology 1994;24(9):2168-74.
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1993: Williams G T; Dariavach P; Venkitaraman A R; Gilmore D J; Neuberger M S
Membrane immunoglobulin without sheath or anchor.
Molecular immunology 1993;30(16):1427-32.
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1992: Venkitaraman A R; Cowling R J
Interleukin 7 receptor functions by recruiting the tyrosine kinase p59fyn through a segment of its cytoplasmic tail.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(24):12083-7.
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1992: Venkitaraman A
Light chain surrogacy.
Current biology : CB 1992;2(10):559-61.
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1991: Venkitaraman A R; Williams G T; Dariavach P; Neuberger M S
The B-cell antigen receptor of the five immunoglobulin classes.
Nature 1991;352(6338):777-81.
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1990: Williams G T; Venkitaraman A R; Gilmore D J; Neuberger M S
The sequence of the mu transmembrane segment determines the tissue specificity of the transport of immunoglobulin M to the cell surface.
The Journal of experimental medicine 1990;171(3):947-52.
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1989: Venkitaraman A R
Use of modified T7 DNA polymerase (sequenase version 2.0) for oligonucleotide site-directed mutagenesis.
Nucleic acids research 1989;17(8):3314.
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