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Dmitry Veprintsev

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TOP 3
Simon M Vogel; Rainer Wilcken; Matthias R Bauer; Tobias Brandt; Alan R Fersht; Andreas C Joerger; Trevor J Rutherford; Dmitry B Veprintsev; Frank M Boeckler
Lithocholic acid is an endogenous inhibitor of MDM4 and MDM2.
María José Sánchez-Barrena; Yvonne Vallis; Dmitry B Veprintsev; Menna R Clatworthy; Gary Doherty; Philip R Evans; Harvey T McMahon
Bin2 is a membrane sculpting N-BAR protein that influences leucocyte podosomes, motility and phagocytosis.
Tobias Brandt; Stefan M V Freund; Daniel P Teufel; Fiona M Townsley; Dmitry B Veprintsev
Molecular basis for modulation of the p53 target selectivity by KLF4.

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2012: Simon M Vogel; Rainer Wilcken; Matthias R Bauer; Tobias Brandt; Alan R Fersht; Andreas C Joerger; Trevor J Rutherford; Dmitry B Veprintsev; Frank M Boeckler
Lithocholic acid is an endogenous inhibitor of MDM4 and MDM2.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(42):16906-10.
2012: María José Sánchez-Barrena; Yvonne Vallis; Dmitry B Veprintsev; Menna R Clatworthy; Gary Doherty; Philip R Evans; Harvey T McMahon
Bin2 is a membrane sculpting N-BAR protein that influences leucocyte podosomes, motility and phagocytosis.
PloS one 2012;7(12):e52401.
2012: Tobias Brandt; Stefan M V Freund; Daniel P Teufel; Fiona M Townsley; Dmitry B Veprintsev
Molecular basis for modulation of the p53 target selectivity by KLF4.
PloS one 2012;7(10):e48252.
2012: Tobias Brandt; Alan R Fersht; Joel L Kaar; Dmitry B Veprintsev
Stability of p53 homologs.
PloS one 2012;7(10):e47889.
2012: Ronen Gabizon; N Lahav; Mario Lebendiker; Deborah E Shalev; Shahar Sukenik; Dmitry B Veprintsev; Tobias Brandt; Assaf Friedler
Specific recognition of p53 tetramers by peptides derived from p53 interacting proteins.
PloS one 2012;7(5):e38060.
2012: Marc de la Roche; Stefan M Freund; Deepti Gupta; Trevor J Rutherford; Barbara Saxty; Dmitry B Veprintsev; Mariann Bienz
An intrinsically labile α-helix abutting the BCL9-binding site of β-catenin is required for its inhibition by carnosic acid.
Nature communications 2012;3():680.
2011: Eyal Arbely; Eviatar Natan; Tobias Brandt; Mark D Allen; Dmitry B Veprintsev; Carol V Robinson; Jason W Chin; Andreas C Joerger; Alan R Fersht
Acetylation of lysine 120 of p53 endows DNA-binding specificity at effective physiological salt concentration.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(20):8251-6.
2011: Mark van Breugel; Masafumi Hirono; Antonina Andreeva; Haru-aki Yanagisawa; Shoko Yamaguchi; Yuki Nakazawa; Nina Morgner; Miriana Petrovich; Ima-Obong Ebong; Carol V Robinson; Christopher M Johnson; Dmitry B Veprintsev; Benoît Zuber
Structures of SAS-6 suggest its organization in centrioles.
Science (New York, N.Y.) 2011;331(6021):1196-9.
2011: Maxim Rossmann; Madhav Sukumaran; Andrew C Penn; Dmitry B Veprintsev; M Madan Babu; Ingo H Greger
Subunit-selective N-terminal domain associations organize the formation of AMPA receptor heteromers.
The EMBO journal 2011;30(5):959-71.
2011: Roberto Melero; Sridharan Rajagopalan; Melisa Lázaro; Andreas C Joerger; Tobias Brandt; Dmitry B Veprintsev; Gorka Lasso; David Gil; Sjors H W Scheres; José María Carazo; Alan R Fersht; Mikel Valle
Electron microscopy studies on the quaternary structure of p53 reveal different binding modes for p53 tetramers in complex with DNA.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(2):557-62.
2010: Maria A Oliva; Sven Halbedel; Stefan M Freund; Pavel Dutow; Thomas A Leonard; Dmitry B Veprintsev; Leendert W Hamoen; Jan Löwe
Features critical for membrane binding revealed by DivIVA crystal structure.
The EMBO journal 2010;29(12):1988-2001.
2010: J van Dieck; T Brandt; D P Teufel; Dmitry B Veprintsev; A C Joerger; Alan Fersht
Molecular basis of S100 proteins interacting with the p53 homologs p63 and p73.
Oncogene 2010;29(14):2024-35.
2009: Andreas C Joerger; Sridharan Rajagopalan; Eviatar Natan; Dmitry B Veprintsev; Carol V Robinson; Alan R Fersht
Structural evolution of p53, p63, and p73: implication for heterotetramer formation.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(42):17705-10.
2009: Jan van Dieck; Maria R Fernandez-Fernandez; Dmitry B Veprintsev; Alan Fersht
Modulation of the oligomerization state of p53 by differential binding of proteins of the S100 family to p53 monomers and tetramers.
The Journal of biological chemistry 2009;284(20):13804-11.
2009: Miriana Petrovich; Dmitry B Veprintsev
Effects of CpG methylation on recognition of DNA by the tumour suppressor p53.
Journal of molecular biology 2009;386(1):72-80.
2009: Tobias Brandt; Miriana Petrovich; Andreas C Joerger; Dmitry B Veprintsev
Conservation of DNA-binding specificity and oligomerisation properties within the p53 family.
BMC genomics 2009;10():628.
2008: Sridharan Rajagopalan; Agnes M Jaulent; Mark Wells; Dmitry B Veprintsev; Alan Fersht
14-3-3 activation of DNA binding of p53 by enhancing its association into tetramers.
Nucleic acids research 2008;36(18):5983-91.
2008: Maria M García-Alai; Henning Tidow; Eviatar Natan; Fiona M Townsley; Dmitry B Veprintsev; Alan Fersht
The novel p53 isoform "delta p53" is a misfolded protein and does not bind the p21 promoter site.
Protein science : a publication of the Protein Society 2008;17(10):1671-8.
2008: Sara Ghazi-Tabatabai; Suraj Saksena; Judith M Short; Ajaybabu V Pobbati; Dmitry B Veprintsev; R Anthony Crowther; Scott D Emr; Edward H Egelman; Roger L Williams
Structure and disassembly of filaments formed by the ESCRT-III subunit Vps24.
Structure (London, England : 1993) 2008;16(9):1345-56.
2008: Frank M Boeckler; Andreas C Joerger; Gaurav Jaggi; Trevor J Rutherford; Dmitry B Veprintsev; Alan Fersht
Targeted rescue of a destabilized mutant of p53 by an in silico screened drug.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(30):10360-5.
2008: Shahar Rotem; Chen Katz; Hadar Benyamini; Mario Lebendiker; Dmitry B Veprintsev; Stefan Rüdiger; tsafi danieli; Assaf Friedler
The structure and interactions of the proline-rich domain of ASPP2.
The Journal of biological chemistry 2008;283(27):18990-9.
2008: Dmitry B Veprintsev; Alan Fersht
Algorithm for prediction of tumour suppressor p53 affinity for binding sites in DNA.
Nucleic acids research 2008;36(5):1589-98.
2007: Zvi Hayouka; Joseph Rosenbluh; Aviad Levin; Shoshana Loya; Mario Lebendiker; Dmitry B Veprintsev; Moshe Kotler; Amnon Hizi; Abraham Loyter; Assaf Friedler
Inhibiting HIV-1 integrase by shifting its oligomerization equilibrium.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(20):8316-21.
2007: David J Gill; Hsiangling Teo; Ji Sun; Olga Perisic; Dmitry B Veprintsev; Scott D Emr; Roger L Williams
Structural insight into the ESCRT-I/-II link and its role in MVB trafficking.
The EMBO journal 2007;26(2):600-12.
2007: David J Gill; Hsiangling Teo; Ji Sun; Olga Perisic; Dmitry B Veprintsev; Yvonne Vallis; Scott D Emr; Roger L Williams
Structural studies of phosphoinositide 3-kinase-dependent traffic to multivesicular bodies.
Biochemical Society symposium 2007;(74):47-57.
2006: Henning Tidow; Dmitry B Veprintsev; Stefan M V Freund; Alan Fersht
Effects of oncogenic mutations and DNA response elements on the binding of p53 to p53-binding protein 2 (53BP2).
The Journal of biological chemistry 2006;281(43):32526-33.
2006: Hsiangling Teo; David J Gill; Ji Sun; Olga Perisic; Dmitry B Veprintsev; Yvonne Vallis; Scott D Emr; Roger L Williams
ESCRT-I core and ESCRT-II GLUE domain structures reveal role for GLUE in linking to ESCRT-I and membranes.
Cell 2006;125(1):99-111.
2006: Dmitry B Veprintsev; Stefan M V Freund; Antonina Andreeva; Stacey E Rutledge; Henning Tidow; José Manuel Pérez Cañadillas; Caroline M Blair; Alan Fersht
Core domain interactions in full-length p53 in solution.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(7):2115-9.
2006: Grace W Yu; Stefan Rudiger; Dmitry B Veprintsev; Stefan M V Freund; M Rosario Fernandez-Fernandez; Alan Fersht
The central region of HDM2 provides a second binding site for p53.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(5):1227-32.
2005: Gayatri B Chavali; Caroline M S Ekblad; Balaku P Basu; Nigel C Brissett; Dmitry B Veprintsev; Luke Hughes-Davies; Tony Kouzarides; Laura S Itzhaki; Aidan J Doherty
Crystal structure of the ENT domain of human EMSY.
Journal of molecular biology 2005;350(5):964-73.
2005: Caroline M S Ekblad; Gayatri B Chavali; Balaku P Basu; Stefan M V Freund; Dmitry B Veprintsev; Luke Hughes-Davies; Tony Kouzarides; Aidan J Doherty; Laura S Itzhaki
Binding of EMSY to HP1beta: implications for recruitment of HP1beta and BS69.
EMBO reports 2005;6(7):675-80.
2005: Nuria Sánchez-Puig; Dmitry B Veprintsev; Alan Fersht
Human full-length Securin is a natively unfolded protein.
Protein science : a publication of the Protein Society 2005;14(6):1410-8.
2005: Richard L Weinberg; Dmitry B Veprintsev; Mark Bycroft; Alan Fersht
Comparative binding of p53 to its promoter and DNA recognition elements.
Journal of molecular biology 2005;348(3):589-96.
2005: andreas joerger; Hwee Ching Ang; Dmitry B Veprintsev; Caroline M Blair; Alan Fersht
Structures of p53 cancer mutants and mechanism of rescue by second-site suppressor mutations.
The Journal of biological chemistry 2005;280(16):16030-7.
2005: Assaf Friedler; Dmitry B Veprintsev; Stefan M V Freund; Karoly I von Glos; Alan Fersht
Modulation of binding of DNA to the C-terminal domain of p53 by acetylation.
Structure (London, England : 1993) 2005;13(4):629-36.
2005: Maria Rosario Fernandez-Fernandez; Dmitry B Veprintsev; Alan Fersht
Proteins of the S100 family regulate the oligomerization of p53 tumor suppressor.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(13):4735-40.
2005: Assaf Friedler; Dmitry B Veprintsev; Trevor Rutherford; Karoly I von Glos; Alan Fersht
Binding of Rad51 and other peptide sequences to a promiscuous, highly electrostatic binding site in p53.
The Journal of biological chemistry 2005;280(9):8051-9.
2005: Nuria Sánchez-Puig; Dmitry B Veprintsev; Alan Fersht
Binding of natively unfolded HIF-1alpha ODD domain to p53.
Molecular cell 2005;17(1):11-21.
2004: Richard L Weinberg; Stefan M V Freund; Dmitry B Veprintsev; Mark Bycroft; Alan Fersht
Regulation of DNA binding of p53 by its C-terminal domain.
Journal of molecular biology 2004;342(3):801-11.
2004: Beatriz González; Michael J Schell; Andrew J Letcher; Dmitry B Veprintsev; Robin F Irvine; Roger L Williams
Structure of a human inositol 1,4,5-trisphosphate 3-kinase: substrate binding reveals why it is not a phosphoinositide 3-kinase.
Molecular cell 2004;15(5):689-701.
2004: Richard L Weinberg; Dmitry B Veprintsev; Alan Fersht
Cooperative binding of tetrameric p53 to DNA.
Journal of molecular biology 2004;341(5):1145-59.
2004: Hsiangling Teo; Dmitry B Veprintsev; Roger L Williams
Structural insights into endosomal sorting complex required for transport (ESCRT-I) recognition of ubiquitinated proteins.
The Journal of biological chemistry 2004;279(27):28689-96.
2004: Caroline M S Ekblad; Assaf Friedler; Dmitry B Veprintsev; Richard L Weinberg; Laura S Itzhaki
Comparison of BRCT domains of BRCA1 and 53BP1: a biophysical analysis.
Protein science : a publication of the Protein Society 2004;13(3):617-25.
2004: Yu Wai Chen; Mark D Allen; Dmitry B Veprintsev; Jan Löwe; Mark Bycroft
The structure of the AXH domain of spinocerebellar ataxin-1.
The Journal of biological chemistry 2004;279(5):3758-65.
2003: Bojana Panic; Olga Perisic; Dmitry B Veprintsev; Roger L Williams; Sean Munro
Structural basis for Arl1-dependent targeting of homodimeric GRIP domains to the Golgi apparatus.
Molecular cell 2003;12(4):863-74.
2003: Assaf Friedler; Dmitry B Veprintsev; Lars O Emrén; Alan Fersht
Kinetic instability of p53 core domain mutants: implications for rescue by small molecules.
The Journal of biological chemistry 2003;278(26):24108-12.
2002: Stefan Rudiger; Stefan M V Freund; Dmitry B Veprintsev; Alan Fersht
CRINEPT-TROSY NMR reveals p53 core domain bound in an unfolded form to the chaperone Hsp90.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(17):11085-90.
2002: Thomas M Rippin; Stefan M V Freund; Dmitry B Veprintsev; Alan Fersht
Recognition of DNA by p53 core domain and location of intermolecular contacts of cooperative binding.
Journal of molecular biology 2002;319(2):351-8.
2002: Assaf Friedler; Lars O Emrén; Dmitry B Veprintsev; Stefan M V Freund; Thomas M Rippin; Penka V Nikolova; Mark R Proctor; Stefan Rüdiger; Alan Fersht
A peptide that binds and stabilizes p53 core domain: chaperone strategy for rescue of oncogenic mutants.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(2):937-42.