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Ronald Vergona

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Le-Ning Zhang; Sharlene Velichko; Jon Vincelette; Richard M Fitch; Ronald Vergona; Mark E Sullivan; Ed Croze; Yi-Xin Wang
Interferon-beta attenuates angiotensin II-accelerated atherosclerosis and vascular remodeling in apolipoprotein E deficient mice.
Hu Sheng Qian; J-M Gu; Perry Liu; Katalin Kauser; Meredith Halks-Miller; Ronald Vergona; Mark E Sullivan; William P Dole; Gary G Deng
Overexpression of PAI-1 prevents the development of abdominal aortic aneurysm in mice.
Le-Ning Zhang; Valdeci da Cunha; Baby Martin-McNulty; John C Rutledge; Ronald Vergona; Mark E Sullivan; Yi-Xin Jim Wang
Monocyte chemoattractant protein-1 or macrophage inflammatory protein-1alpha deficiency does not affect angiotensin II-induced intimal hyperplasia in carotid artery ligation model.

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2008: Le-Ning Zhang; Sharlene Velichko; Jon Vincelette; Richard M Fitch; Ronald Vergona; Mark E Sullivan; Ed Croze; Yi-Xin Wang
Interferon-beta attenuates angiotensin II-accelerated atherosclerosis and vascular remodeling in apolipoprotein E deficient mice.
Atherosclerosis 2008;197(1):204-11.
2008: Hu Sheng Qian; J-M Gu; Perry Liu; Katalin Kauser; Meredith Halks-Miller; Ronald Vergona; Mark E Sullivan; William P Dole; Gary G Deng
Overexpression of PAI-1 prevents the development of abdominal aortic aneurysm in mice.
Gene therapy 2008;15(3):224-32.
2007: Le-Ning Zhang; Valdeci da Cunha; Baby Martin-McNulty; John C Rutledge; Ronald Vergona; Mark E Sullivan; Yi-Xin Jim Wang
Monocyte chemoattractant protein-1 or macrophage inflammatory protein-1alpha deficiency does not affect angiotensin II-induced intimal hyperplasia in carotid artery ligation model.
Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology 2007;16(4):231-6.
2007: Yi-Xin Wang; Valdeci da Cunha; Jon Vincelette; Kathy White; Sharlene Velichko; Yifan Xu; Cynthia Gross; Richard M Fitch; Meredith Halks-Miller; Brent R Larsen; Toshitaka Yajima; Kirk U Knowlton; Ronald Vergona; Mark E Sullivan; Ed Croze
Antiviral and myocyte protective effects of murine interferon-beta and -{alpha}2 in coxsackievirus B3-induced myocarditis and epicarditis in Balb/c mice.
American journal of physiology. Heart and circulatory physiology 2007;293(1):H69-76.
2007: Yi-Xin Wang; Jon Vincelette; Valdeci da Cunha; Baby Martin-McNulty; Cornell Mallari; Richard M Fitch; Serene Alexander; Imadul Islam; Brad Buckman; Shendong Yuan; Joseph M Post; Babu Subramanyam; Ronald Vergona; Mark E Sullivan; William P Dole; John Morser; Judi Bryant
A novel P2Y(12) adenosine diphosphate receptor antagonist that inhibits platelet aggregation and thrombus formation in rat and dog models.
Thrombosis and haemostasis 2007;97(5):847-55.
2007: David D Davey; Marc Adler; Damian O Arnaiz; Keith Eagen; Shawn Erickson; William J Guilford; Margaret Kenrick; Michael M Morrissey; Mike Ohlmeyer; Gonghua Pan; Vidyadhar M Paradkar; John Parkinson; Mark A Polokoff; Kurt Saionz; Cecile Santos; Babu Subramanyam; Ronald Vergona; Robert G Wei; Marc Whitlow; Bin Ye; Zuchun Spring Zhao; James J Devlin; Gary Phillips
Design, synthesis, and activity of 2-imidazol-1-ylpyrimidine derived inducible nitric oxide synthase dimerization inhibitors.
Journal of medicinal chemistry 2007;50(6):1146-57.
2007: Monica J Kochanny; Marc Adler; Janice Ewing; Brian D Griedel; Elena Ho; Rushad Karanjawala; Wheeseong Lee; Dao Lentz; Amy M Liang; Michael M Morrissey; Gary B Phillips; Joseph Post; Karna L Sacchi; Steven T Sakata; Babu Subramanyam; Ronald Vergona; Janette Walters; Kathy A White; Marc Whitlow; Bin Ye; Zuchun Zhao; Kenneth J Shaw
Substituted thiophene-anthranilamides as potent inhibitors of human factor Xa.
Bioorganic & medicinal chemistry 2007;15(5):2127-46.
2007: Imadul Islam; Judi Bryant; Karen May; Raju Mohan; Shendong Yuan; Lorraine Kent; John Morser; Lei Zhao; Ronald Vergona; Kathy White; Marc Adler; Marc Whitlow; Brad Buckman
3-Mercaptopropionic acids as efficacious inhibitors of activated thrombin activatable fibrinolysis inhibitor (TAFIa).
Bioorganic & medicinal chemistry letters 2007;17(5):1349-54.
2007: Baby Martin-McNulty; Lening Zhang; Valdeci da Cunha; Jon Vincelette; John C Rutledge; Ronald Vergona; Mark E Sullivan; Yi-Xin Wang
Urokinase-type plasminogen activator deficiency (uPA-KO) prevented carotid artery ligation-induced vascular remodeling in mice.
Translational research : the journal of laboratory and clinical medicine 2007;149(2):70-5.
2007: Jon Vincelette; Yifan Xu; Le-Ning Zhang; Caralee J Schaefer; Ronald Vergona; Mark E Sullivan; Thomas G Hampton; Yi-Xin Jim Wang
Gait analysis in a murine model of collagen-induced arthritis.
Arthritis research & therapy 2007;9(6):R123.
2007: Yi-Xin Wang; Valdeci da Cunha; Jon Vincelette; Lei Zhao; Mariko Nagashima; Kohichi Kawai; Shendong Yuan; Kumar Emayan; Imadul Islam; Junko Hosoya; Mark E Sullivan; William P Dole; John Morser; Brad Buckman; Ronald Vergona
A novel inhibitor of activated thrombin activatable fibrinolysis inhibitor (TAFIa) - part II: enhancement of both exogenous and endogenous fibrinolysis in animal models of thrombosis.
Thrombosis and haemostasis 2007;97(1):54-61.
2007: Yi-Xin Wang; Lei Zhao; Mariko Nagashima; Jon Vincelette; Drew Sukovich; Weiwei Li; Babu Subramanyam; Shendong Yuan; Kumar Emayan; Imadul Islam; Paul Hrvatin; Judi Bryant; David R Light; Ronald Vergona; John Morser; Brad Buckman
A novel inhibitor of activated thrombin-activatable fibrinolysis inhibitor (TAFIa) - part I: pharmacological characterization.
Thrombosis and haemostasis 2007;97(1):45-53.
2006: Hu Sheng Qian; Perry Liu; Ling-Yuh Huw; Ann Orme; Meredith Halks-Miller; S M Hill; F Jin; Peter J Kretschmer; Eric Blasko; Linda Cashion; Paul Szymanski; Ronald Vergona; Richard N Harkins; J Yu; W C Sessa; William P Dole; Gabor M Rubanyi; Katalin Kauser
Effective treatment of vascular endothelial growth factor refractory hindlimb ischemia by a mutant endothelial nitric oxide synthase gene.
Gene therapy 2006;13(18):1342-50.
2006: Valdeci da Cunha; Baby Martin-McNulty; Jon Vincelette; David F Choy; We-Wei Li; Miriam Schroeder; Mithra Mahmoudi; Meredith Halks-Miller; Dennis W Wilson; Ronald Vergona; Mark E Sullivan; Yi-Xin Jim Wang
Angiotensin II induces histomorphologic features of unstable plaque in a murine model of accelerated atherosclerosis.
Journal of vascular surgery 2006;44(2):364-71.
2006: Jon Vincelette; Baby Martin-McNulty; Ronald Vergona; Mark E Sullivan; Yi-Xin Wang
Reduced cardiac functional reserve in apolipoprotein E knockout mice.
Translational research : the journal of laboratory and clinical medicine 2006;148(1):30-6.
2006: Le-Ning Zhang; Dennis W Wilson; Valdeci da Cunha; Mark E Sullivan; Ronald Vergona; John C Rutledge; Yi-Xin Wang
Endothelial NO synthase deficiency promotes smooth muscle progenitor cells in association with upregulation of stromal cell-derived factor-1alpha in a mouse model of carotid artery ligation.
Arteriosclerosis, thrombosis, and vascular biology 2006;26(4):765-72.
2006: Valdeci da Cunha; Baby Martin-McNulty; Jon Vincelette; Lening Zhang; John C Rutledge; Dennis W Wilson; Ronald Vergona; Mark E Sullivan; Yi-Xin Wang
Interaction between mild hypercholesterolemia, HDL-cholesterol levels, and angiotensin II in intimal hyperplasia in mice.
Journal of lipid research 2006;47(3):476-83.
2005: Jon Vincelette; Rene Pagila; Kohichi Kawai; Masaaki Ishii; Yuko Horimizu; Ronald Vergona; Mark E Sullivan; John Morser; William P Dole; Yi-Xin Wang
Inhibition of rho-kinase by hydroxyfasudil prevents vasopressin-induced myocardial ischemia in Donryu rats by attenuating coronary vasoconstriction.
Pharmacology 2005;75(3):145-51.
2005: Baby Martin-McNulty; Jon Vincelette; Ronald Vergona; Mark E Sullivan; Yi-Xin Wang
Noninvasive measurement of abdominal aortic aneurysms in intact mice by a high-frequency ultrasound imaging system.
Ultrasound in medicine & biology 2005;31(6):745-9.
2005: Valdeci da Cunha; Doris M Tham; Baby Martin-McNulty; Gary Deng; Jerrick J Ho; Dennis W Wilson; John C Rutledge; Ronald Vergona; Mark E Sullivan; Yi-Xin Jim Wang
Enalapril attenuates angiotensin II-induced atherosclerosis and vascular inflammation.
Atherosclerosis 2005;178(1):9-17.
2003: Baby Martin-McNulty; Doris M Tham; Valdeci da Cunha; Jerrick J Ho; Dennis W Wilson; John C Rutledge; Gary G Deng; Ronald Vergona; Mark E Sullivan; Yi-Xin Wang
17 Beta-estradiol attenuates development of angiotensin II-induced aortic abdominal aneurysm in apolipoprotein E-deficient mice.
Arteriosclerosis, thrombosis, and vascular biology 2003;23(9):1627-32.
2003: R W Evans; Robert W Powers; Roberta B Ness; Lorna J Cropcho; Ashi Daftary; Gail Harger; Ronald Vergona; David N Finegold
Maternal and fetal amino acid concentrations and fetal outcomes during pre-eclampsia.
Reproduction (Cambridge, England) 2003;125(6):785-90.
2003: Yi Xin Wang; Ning-zheng Dong; Chengliang Wu; Baby Martin-McNulty; Richard M Fitch; Valdeci da Cunha; Jon Vicelette; Katherine Tran; Ronald Vergona; Mark E Sullivan; John Morser; Qingyu Wu
Lipopolysaccharide attenuates thrombolysis in batroxobin-induced lung vasculature fibrin deposition but not in ferrous chloride-induced carotid artery thrombus in rats: role of endogenous PAI-1.
Thrombosis research 2003;111(6):381-7.
2002: Doris M Tham; Baby Martin-McNulty; Yi-xin Wang; Dennis W Wilson; Ronald Vergona; Mark E Sullivan; William P Dole; John C Rutledge
Angiotensin II is associated with activation of NF-kappaB-mediated genes and downregulation of PPARs.
Physiological genomics 2002;11(1):21-30.
2002: Yi-Xin Wang; Richard M Fitch; Weiwei Li; Matthias Werner; Meredith Halks-Miller; Bill Lillis; Ronald Vergona; Joe Post; Mark E Sullivan; Peter F Verhallen
Reduction of cardiac functional reserve and elevation of aortic stiffness in hyperlipidemic Yucatan minipigs with systemic and coronary atherosclerosis.
Vascular pharmacology 2002;39(1-2):69-76.
2002: Yi Xin Wang; Baby Martin-McNulty; Ling-Yuh Huw; Valdeci da Cunha; Joe Post; Josephine W Hinchman; Ronald Vergona; Mark E Sullivan; William P Dole; Katalin Kauser
Anti-atherosclerotic effect of simvastatin depends on the presence of apolipoprotein E.
Atherosclerosis 2002;162(1):23-31.
2002: Howard P Ng; Brad Buckman; Keith Eagen; William J Guilford; Monica J Kochanny; Raju Mohan; Kenneth J Shaw; Shung C Wu; Dao Lentz; Amy Liang; Lan Trinh; Elena Ho; David Smith; Babu Subramanyam; Ronald Vergona; Janette Walters; Kathy A White; Mark E Sullivan; Michael M Morrissey; Gary B Phillips
Design, synthesis, and biological activity of novel factor Xa inhibitors: 4-aryloxy substituents of 2,6-diphenoxypyridines.
Bioorganic & medicinal chemistry 2002;10(3):657-66.
2002: Roberta B Ness; Daniel W Cramer; Marc T Goodman; Susanne Krûger Kjaer; Kathy Mallin; Berit Jul Mosgaard; David M Purdie; Harvey A Risch; Ronald Vergona; Anna H Wu
Infertility, fertility drugs, and ovarian cancer: a pooled analysis of case-control studies.
American journal of epidemiology 2002;155(3):217-24.
2001: Yi Xin Wang; Baby Martin-McNulty; Ana Freay; Drew A Sukovich; Meredith Halks-Miller; W W Li; Ronald Vergona; Mark E Sullivan; John Morser; William P Dole; Gary G Deng
Angiotensin II increases urokinase-type plasminogen activator expression and induces aneurysm in the abdominal aorta of apolipoprotein E-deficient mice.
The American journal of pathology 2001;159(4):1455-64.
2001: Richard M Fitch; Ronald Vergona; Mark E Sullivan; Yi Xin Wang
Nitric oxide synthase inhibition increases aortic stiffness measured by pulse wave velocity in rats.
Cardiovascular research 2001;51(2):351-8.
2001: Roberta B Ness; Jeane Ann Grisso; Ronald Vergona; J Klapper; M Morgan; James E Wheeler
Oral contraceptives, other methods of contraception, and risk reduction for ovarian cancer.
Epidemiology (Cambridge, Mass.) 2001;12(3):307-12.
2001: Richard M Fitch; Valdeci da Cunha; Katalin Kauser; William P Dole; J Parkinson; Ronald Vergona; Mark E Sullivan; Yi Xin Wang
Increased nitric oxide accounts for decreased basal vascular tone and responsiveness in the resistance vessels of high-cholesterol-fed rabbits.
Pharmacology 2001;63(4):220-7.
2000: Craig J Hartley; Anilkumar K Reddy; Sridhar Madala; Baby Martin-McNulty; Ronald Vergona; Mark E Sullivan; Meredith Halks-Miller; George E Taffet; Lloyd H Michael; Mark L Entman; Y X Wang
Hemodynamic changes in apolipoprotein E-knockout mice.
American journal of physiology. Heart and circulatory physiology 2000;279(5):H2326-34.
2000: Roberta B Ness; Jeane Ann Grisso; J Klapper; James J Schlesselman; S Silberzweig; Ronald Vergona; M Morgan; James E Wheeler
Risk of ovarian cancer in relation to estrogen and progestin dose and use characteristics of oral contraceptives. SHARE Study Group. Steroid Hormones and Reproductions.
American journal of epidemiology 2000;152(3):233-41.
2000: Meina Liang; Cornell Mallari; Mary Rosser; Howard P Ng; K May; S Monahan; John G Bauman; Imadul Islam; Ameen Ghannam; Brad Buckman; K Shaw; Guo-Ping Wei; Wei Xu; Z Zhao; E Ho; J Shen; H Oanh; Babu Subramanyam; Ronald Vergona; D Taub; Laura Dunning; S Harvey; RM Snider; Joseph Hesselgesser; Michael M Morrissey; H Daniel Perez
Identification and characterization of a potent, selective, and orally active antagonist of the CC chemokine receptor-1.
The Journal of biological chemistry 2000;275(25):19000-8.
2000: Deborah A Zajchowski; Katalin Kauser; D Zhu; L Webster; S Aberle; F A White; Hsaio-Lai Liu; R Humm; J MacRobbie; P Ponte; Christa Hegele-Hartung; R Knauthe; Karl-Heinrich Fritzemeier; Ronald Vergona; Gabor M Rubanyi
Identification of selective estrogen receptor modulators by their gene expression fingerprints.
The Journal of biological chemistry 2000;275(21):15885-94.
2000: Dana R Abendschein; PK Baum; D J Martin; Ronald Vergona; Joe Post; Galina Rumennik; Mark E Sullivan; Paul R Eisenberg; David R Light
Effects of ZK-807834, a novel inhibitor of factor Xa, on arterial and venous thrombosis in rabbits.
Journal of cardiovascular pharmacology 2000;35(5):796-805.
2000: Roberta B Ness; Jeane Ann Grisso; J Klapper; Ronald Vergona
Racial differences in ovarian cancer risk.
Journal of the National Medical Association 2000;92(4):176-82.
2000: Roberta B Ness; Jeane Ann Grisso; Carrie M Cottreau; J Klapper; Ronald Vergona; James E Wheeler; M Morgan; James J Schlesselman
Factors related to inflammation of the ovarian epithelium and risk of ovarian cancer.
Epidemiology (Cambridge, Mass.) 2000;11(2):111-7.
2000: Kirk McMillan; M Adler; Douglas S Auld; John J Baldwin; Eric Blasko; L J Browne; Daniel Chelsky; D Davey; Roland E Dolle; Keith Eagen; Shawn Erickson; Richard I Feldman; Charles B Glaser; Cornell Mallari; Michael M Morrissey; Michael Ohlmeyer; G Pan; John Parkinson; Gary B Phillips; Mark A Polokoff; Nolan H Sigal; Ronald Vergona; Marc Whitlow; T A Young; James J Devlin
Allosteric inhibitors of inducible nitric oxide synthase dimerization discovered via combinatorial chemistry.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(4):1506-11.
2000: Yi Xin Wang; Meredith Halks-Miller; Ronald Vergona; Mark E Sullivan; Richard M Fitch; Cornell Mallari; Baby Martin-McNulty; Valdeci da Cunha; Ana Freay; Gabor M Rubanyi; Katalin Kauser
Increased aortic stiffness assessed by pulse wave velocity in apolipoprotein E-deficient mice.
American journal of physiology. Heart and circulatory physiology 2000;278(2):H428-34.
1999: J Tse; B Martin-McNaulty; Meredith Halks-Miller; Katalin Kauser; V DelVecchio; Ronald Vergona; Mark E Sullivan; Gabor M Rubanyi
Accelerated atherosclerosis and premature calcified cartilaginous metaplasia in the aorta of diabetic male Apo E knockout mice can be prevented by chronic treatment with 17 beta-estradiol.
Atherosclerosis 1999;144(2):303-13.
1998: Gary B Phillips; Brad Buckman; David D Davey; Keith Eagen; William J Guilford; Josephine W Hinchman; Elena Ho; Sunil Koovakkat; Amy Liang; David R Light; Raju Mohan; Howard P Ng; Joseph M Post; Kenneth J Shaw; D Smith; Babu Subramanyam; Mark E Sullivan; Lan Trinh; Ronald Vergona; Janette Walters; K White; Marc Whitlow; Shung Wu; Wei Xu; Michael M Morrissey
Discovery of N-[2-[5-[Amino(imino)methyl]-2-hydroxyphenoxy]-3, 5-difluoro-6-[3-(4, 5-dihydro-1-methyl-1H-imidazol-2-yl)phenoxy]pyridin-4-yl]-N-methylgl y cine (ZK-807834): a potent, selective, and orally active inhibitor of the blood coagulation enzyme factor Xa.
Journal of medicinal chemistry 1998;41(19):3557-62.