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Lieve Verlinden

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Carlien Leyssens; Lieve Verlinden; Annemieke Verstuyf
Antineoplastic effects of 1,25(OH)2D3 and its analogs in breast, prostate and colorectal cancer.
Sigrid Hatse; Carsten Kriebitzsch; Annouschka Laenen; Diether Lambrechts; Patrick Neven; Robert Paridaens; Gilian Peuteman; Ann Smeets; Thijs Vandorpe; Lieve Verlinden; Annemieke Verstuyf; Roger Bouillon; Olivier Brouckaert; Barbara Brouwers; Marie-Rose Christiaens; Anne-Sophie Dieudonné; Hans Wildiers
Vitamin D status at breast cancer diagnosis: correlation with tumor characteristics, disease outcome, and genetic determinants of vitamin D insufficiency.
Isabelle Clinckspoor; Pierre Delaere; Esther Hauben; Chantal Mathieu; Annick Van den Bruel; Vincent Vander Poorten; Lieve Vanwalleghem; Lieve Verlinden; Annemieke Verstuyf; Brigitte Decallonne
Altered expression of key players in vitamin D metabolism and signaling in malignant and benign thyroid tumors.

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All Publications

2013: Carlien Leyssens; Lieve Verlinden; Annemieke Verstuyf
Antineoplastic effects of 1,25(OH)2D3 and its analogs in breast, prostate and colorectal cancer.
Endocrine-related cancer 2013;20(2):R31-47.
2012: Sigrid Hatse; Carsten Kriebitzsch; Annouschka Laenen; Diether Lambrechts; Patrick Neven; Robert Paridaens; Gilian Peuteman; Ann Smeets; Thijs Vandorpe; Lieve Verlinden; Annemieke Verstuyf; Roger Bouillon; Olivier Brouckaert; Barbara Brouwers; Marie-Rose Christiaens; Anne-Sophie Dieudonné; Hans Wildiers
Vitamin D status at breast cancer diagnosis: correlation with tumor characteristics, disease outcome, and genetic determinants of vitamin D insufficiency.
Carcinogenesis 2012;33(7):1319-26.
2012: Isabelle Clinckspoor; Pierre Delaere; Esther Hauben; Chantal Mathieu; Annick Van den Bruel; Vincent Vander Poorten; Lieve Vanwalleghem; Lieve Verlinden; Annemieke Verstuyf; Brigitte Decallonne
Altered expression of key players in vitamin D metabolism and signaling in malignant and benign thyroid tumors.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2012;60(7):502-11.
2011: Carsten Kriebitzsch; Paul Lips; Mark B Meyer; J Wesley Pike; Karin Swart; Natasja M van Schoor; Lieve Verlinden; Ruma Banerjee; Steven Boonen; Roger Bouillon; Carsten Carlberg; Guy Eelen; Victor M Vitvitsky; Annemieke Verstuyf
1,25-dihydroxyvitamin D3 influences cellular homocysteine levels in murine preosteoblastic MC3T3-E1 cells by direct regulation of cystathionine β-synthase.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2011;26(12):2991-3000.
2011: E Vanoirbeek; Lieve Verlinden; Roger Bouillon; Guy Eelen; D Feldman; A Krishnan; Annemieke Verstuyf
The anti-cancer and anti-inflammatory actions of 1,25(OH)₂D₃.
Best practice & research. Clinical endocrinology & metabolism 2011;25(4):593-604.
2011: Lieve Verlinden; Annemieke Verstuyf; Guy Eelen; Roger Bouillon; Paloma Ordóñez-Morán; María Jesús Larriba; Alberto Muñoz; Natacha Rochel; Yoshiteru Sato; Dino Moras; Miguel Maestro; Samuel Seoane; Fernando Dominguez; Silvina Eduardo-Canosa; Daniel Nicoletti; Edelmiro Moman; Antonio Mouriño
Synthesis, structure, and biological activity of des-side chain analogues of 1α,25-dihydroxyvitamin D3 with substituents at C18.
ChemMedChem 2011;6(5):788-93.
2010: Guy Eelen; Lieve Verlinden; Roger Bouillon; Pierre J De Clercq; Alberto Muñoz; Annemieke Verstuyf
CD-ring modified vitamin D3 analogs and their superagonistic action.
The Journal of steroid biochemistry and molecular biology 2010;121(1-2):417-9.
2009: Laura Sánchez-Abella; Susana Fernández; Annemieke Verstuyf; Lieve Verlinden; Vicente Gotor; Miguel Ferrero
Synthesis, conformational analysis, and biological evaluation of 19-nor-vitamin D3 analogues with A-ring modifications.
Journal of medicinal chemistry 2009;52(19):6158-62.
2009: Els Vanoirbeek; Guy Eelen; Lieve Verlinden; Kathleen Marchal; Kristof Engelen; Bart De Moor; Ine Beullens; Suzanne Marcelis; Pierre J De Clercq; Roger Bouillon; Annemieke Verstuyf
Microarray analysis of MCF-7 breast cancer cells treated with 1,25-dihydroxyvitamin D3 or a 17-methyl-D-ring analog.
Anticancer research 2009;29(9):3585-90.
2009: Guy Eelen; Lieve Verlinden; JM Laureys; Suzanne Marcelis; Pierre J De Clercq; Chantal Mathieu; Roger Bouillon; Annemieke Verstuyf
Antiproliferative and calcemic actions of trans-decalin CD-ring analogs of 1,25-dihydroxyvitamin D3.
Anticancer research 2009;29(9):3579-84.
2009: Carsten Kriebitzsch; Lieve Verlinden; Guy Eelen; Biauw Keng Tan; Mark Van Camp; Roger Bouillon; Annemieke Verstuyf
The impact of 1,25(OH)2D3 and its structural analogs on gene expression in cancer cells--a microarray approach.
Anticancer research 2009;29(9):3471-83.
2008: Laura Sánchez-Abella; Susana Fernández; Annemieke Verstuyf; Lieve Verlinden; Vicente Gotor; Miguel Ferrero
Synthesis and biological activity of previtamin D(3) analogues with A-ring modifications.
Bioorganic & medicinal chemistry 2008;16(24):10244-50.
2008: Guy Eelen; Noelia Valle; Yoshiteru Sato; Natacha Rochel; Lieve Verlinden; Pierre J De Clercq; Dino Moras; Roger Bouillon; Alberto Muñoz; Annemieke Verstuyf
Superagonistic fluorinated vitamin D3 analogs stabilize helix 12 of the vitamin D receptor.
Chemistry & biology 2008;15(10):1029-34.
2008: Roger Bouillon; Geert Carmeliet; Lieve Verlinden; Evelyne van Etten; Annemieke Verstuyf; Hilary F Luderer; Liesbet Lieben; Chantal Mathieu; Marie Demay
Vitamin D and human health: lessons from vitamin D receptor null mice.
Endocrine reviews 2008;29(6):726-76.
2008: Guy Eelen; Isabelle Vanden Bempt; Lieve Verlinden; Maria Drijkoningen; A Smeets; Patrick Neven; Marie-Rose Christiaens; Kathleen Marchal; Roger Bouillon; A Verstuyf
Expression of the BRCA1-interacting protein Brip1/BACH1/FANCJ is driven by E2F and correlates with human breast cancer malignancy.
Oncogene 2008;27(30):4233-41.
2007: Lieve Verlinden; Isabelle Vanden Bempt; Guy Eelen; Maria Drijkoningen; Ilse Verlinden; Kathleen Marchal; Christiane De Wolf-Peeters; Marie-Rose Christiaens; Luc Michiels; Roger Bouillon; Annemieke Verstuyf
The E2F-regulated gene Chk1 is highly expressed in triple-negative estrogen receptor /progesterone receptor /HER-2 breast carcinomas.
Cancer research 2007;67(14):6574-81.
2007: Laura Sánchez-Abella; Susana Fernández; Annemieke Verstuyf; Lieve Verlinden; Miguel Ferrero; Vicente Gotor
Synthesis and biological evaluation of new 6-s-cis locked 1,2,25-trihydroxyprevitamin D3 analogues.
Bioorganic & medicinal chemistry 2007;15(12):4193-202.
2007: Lieve Verlinden; Guy Eelen; Ruth Van Hellemont; Kristof Engelen; Ine Beullens; Mark Van Camp; Kathleen Marchal; Chantal Mathieu; Roger Bouillon; Annemieke Verstuyf
1alpha,25-Dihydroxyvitamin D3-induced down-regulation of the checkpoint proteins, Chk1 and Claspin, is mediated by the pocket proteins p107 and p130.
The Journal of steroid biochemistry and molecular biology 2007;103(3-5):411-5.
2007: Evelyne van Etten; Lieve Verlinden; Annapaula Giulietti; Elizabeth Ramos Lopez; Dumitru D Branisteanu; Gabriela B Ferreira; Lut Overbergh; Annemieke Verstuyf; Roger Bouillon; Bart O Roep; Klaus Badenhoop; Chantal Mathieu
The vitamin D receptor gene FokI polymorphism: functional impact on the immune system.
European journal of immunology 2007;37(2):395-405.
2007: Guy Eelen; Conny Gysemans; Lieve Verlinden; E Vanoirbeek; Pierre J De Clercq; Dirk Van Haver; Chantal Mathieu; Roger Bouillon; Annemieke Verstuyf
Mechanism and potential of the growth-inhibitory actions of vitamin D and ana-logs.
Current medicinal chemistry 2007;14(17):1893-910.
2006: Roger Bouillon; Guy Eelen; Lieve Verlinden; Chantal Mathieu; Geert Carmeliet; Annemieke Verstuyf
Vitamin D and cancer.
The Journal of steroid biochemistry and molecular biology 2006;102(1-5):156-62.
2006: Daniel Oves; Susana Fernández; Lieve Verlinden; Roger Bouillon; Annemieke Verstuyf; Miguel Ferrero; Vicente Gotor
Novel A-ring homodimeric C-3-carbamate analogues of 1alpha,25-dihydroxyvitamin D3: synthesis and preliminary biological evaluation.
Bioorganic & medicinal chemistry 2006;14(22):7512-9.
2006: Guy Eelen; Lieve Verlinden; Pierre J De Clercq; Maurits Vandewalle; Roger Bouillon; Annemieke Verstuyf
Vitamin D analogs and coactivators.
Anticancer research 2006;26(4A):2717-21.
2006: Katinka Stoffels; Lut Overbergh; Annapaula Giulietti; Lieve Verlinden; Roger Bouillon; Chantal Mathieu
Immune regulation of 25-hydroxyvitamin-D3-1alpha-hydroxylase in human monocytes.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2006;21(1):37-47.
2005: Lieve Verlinden; Guy Eelen; Ine Beullens; Mark Van Camp; Paul van Hummelen; Kristof Engelen; Ruth Van Hellemont; Kathleen Marchal; Bart De Moor; Floris Foijer; Hein te Riele; Monique Beullens; Mathieu Bollen; Chantal Mathieu; Roger Bouillon; Annemieke Verstuyf
Characterization of the condensin component Cnap1 and protein kinase Melk as novel E2F target genes down-regulated by 1,25-dihydroxyvitamin D3.
The Journal of biological chemistry 2005;280(45):37319-30.
2005: Roger Bouillon; Lieve Verlinden; Guy Eelen; Pierre J De Clercq; Maurits Vandewalle; Chantal Mathieu; Annemieke Verstuyf
Mechanisms for the selective action of Vitamin D analogs.
The Journal of steroid biochemistry and molecular biology 2005;97(1-2):21-30.
2005: Guy Eelen; Lieve Verlinden; Mark Van Camp; Frank Claessens; Pierre J De Clercq; Maurits Vandewalle; Roger Bouillon; Annemieke Verstuyf
Altered Vitamin D receptor-coactivator interactions reflect superagonism of Vitamin D analogs.
The Journal of steroid biochemistry and molecular biology 2005;97(1-2):65-8.
2005: Guy Eelen; Lieve Verlinden; Natacha Rochel; Frank Claessens; Pierre J De Clercq; Maurits Vandewalle; Giuseppe Tocchini-Valentini; Dino Moras; Roger Bouillon; Annemieke Verstuyf
Superagonistic action of 14-epi-analogs of 1,25-dihydroxyvitamin D explained by vitamin D receptor-coactivator interaction.
Molecular pharmacology 2005;67(5):1566-73.
2004: Guy Eelen; Lieve Verlinden; Mark Van Camp; Chantal Mathieu; Geert Carmeliet; Roger Bouillon; Annemieke Verstuyf
Microarray analysis of 1alpha,25-dihydroxyvitamin D3-treated MC3T3-E1 cells.
The Journal of steroid biochemistry and molecular biology 2004;89-90(1-5):405-7.
2004: Pierre J De Clercq; Ibrahim Murad; Ling-Jie Gao; Yong-Jun Chen; Dirk Van Haver; Maurits Vandewalle; Annemieke Verstuyf; Lieve Verlinden; Christel Verboven; Roger Bouillon
Biological activity and conformational analysis of C20 and C14 epimers of CD-ring modified trans-decalin 1alpha,25-dihydroxyvitamin D analogs.
The Journal of steroid biochemistry and molecular biology 2004;89-90(1-5):61-6.
2004: Guy Eelen; Lieve Verlinden; Mark Van Camp; Paul van Hummelen; Kathleen Marchal; Bart De Moor; Chantal Mathieu; Geert Carmeliet; Roger Bouillon; Annemieke Verstuyf
The effects of 1alpha,25-dihydroxyvitamin D3 on the expression of DNA replication genes.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2004;19(1):133-46.
2003: Lieve Verlinden; Annemieke Verstuyf; Christel Verboven; Guy Eelen; Camiel J De Ranter; Ling-Jie Gao; Yong-Jun Chen; Ibrahim Murad; Mihwa Choi; Keiko Yamamoto; Sachiko Yamada; Dirk Van Haver; Maurits Vandewalle; Pierre J De Clercq; Roger Bouillon
Previtamin D3 with a trans-fused decalin CD-ring has pronounced genomic activity.
The Journal of biological chemistry 2003;278(37):35476-82.
2003: Evelyne van Etten; Brigitte Decallonne; Lieve Verlinden; Annemieke Verstuyf; Roger Bouillon; Chantal Mathieu
Analogs of 1alpha,25-dihydroxyvitamin D3 as pluripotent immunomodulators.
Journal of cellular biochemistry 2003;88(2):223-6.
2003: Yong-Jun Chen; Ling-Jie Gao; Ibrahim Murad; Annemieke Verstuyf; Lieve Verlinden; Christel Verboven; Roger Bouillon; Davide Viterbo; Marco Milanesio; Dirk Van Haver; Maurits Vandewalle; Pierre J De Clercq
Synthesis, biological activity, and conformational analysis of CD-ring modified trans-decalin 1 alpha,25-dihydroxyvitamin D analogs.
Organic & biomolecular chemistry 2003;1(2):257-67.
2003: Roger Bouillon; Annemieke Verstuyf; Lieve Verlinden; Guy Eelen; Chantal Mathieu
Prospects for vitamin D receptor modulators as candidate drugs for cancer and (auto)immune diseases.
Recent results in cancer research. Fortschritte der Krebsforschung. Progrès dans les recherches sur le cancer 2003;164():353-6.
2002: Yan Ji; Andrzej Kutner; Annemieke Verstuyf; Lieve Verlinden; George P Studzinski
Derivatives of vitamins D2 and D3 activate three MAPK pathways and upregulate pRb expression in differentiating HL60 cells.
Cell cycle (Georgetown, Tex.) 2002;1(6):410-5.
2001: Lieve Verlinden; Annemieke Verstuyf; Marcus Quack; Mark Van Camp; Evelyne van Etten; Pierre J De Clercq; Maurits Vandewalle; Carsten Carlberg; Roger Bouillon
Interaction of two novel 14-epivitamin D3 analogs with vitamin D3 receptor-retinoid X receptor heterodimers on vitamin D3 responsive elements.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2001;16(4):625-38.
2000: Lieve Verlinden; Annemieke Verstuyf; Mark Van Camp; S Marcelis; Katrien Sabbe; X Y Zhao; Pierre J De Clercq; Maurits Vandewalle; Roger Bouillon
Two novel 14-Epi-analogues of 1,25-dihydroxyvitamin D3 inhibit the growth of human breast cancer cells in vitro and in vivo.
Cancer research 2000;60(10):2673-9.
2000: Annemieke Verstuyf; Siegfried Segaert; Lieve Verlinden; Roger Bouillon; C Mathieu
Recent developments in the use of vitamin D analogues.
Expert opinion on investigational drugs 2000;9(3):443-55.
2000: Annemieke Verstuyf; Lieve Verlinden; Evelyne van Etten; L Shi; Y Wu; C D'Halleweyn; Dirk Van Haver; G D Zhu; Yong-Jun Chen; X Zhou; M R Haussler; Pierre J De Clercq; Maurits Vandewalle; Hugo Van Baelen; Chantal Mathieu; Roger Bouillon
Biological activity of CD-ring modified 1alpha,25-dihydroxyvitamin D analogues: C-ring and five-membered D-ring analogues.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2000;15(2):237-52.
1999: Annemieke Verstuyf; Lieve Verlinden; Siegfried Segaert; Evelyne van Etten; C Mathieu; R Bouillon
Nonclassical effects of 1alpha,25-dihydroxyvitamin D(3) and its analogs.
Mineral and electrolyte metabolism 1999;25(4-6):345-8.
1998: Lieve Verlinden; Annemieke Verstuyf; R Convents; S Marcelis; Mark Van Camp; Roger Bouillon
Action of 1,25(OH)2D3 on the cell cycle genes, cyclin D1, p21 and p27 in MCF-7 cells.
Molecular and cellular endocrinology 1998;142(1-2):57-65.
1998: Annemieke Verstuyf; Siegfried Segaert; Lieve Verlinden; Kristina Casteels; Roger Bouillon; Chantal Mathieu
Recent developments in the use of vitamin D analogues.
Current opinion in nephrology and hypertension 1998;7(4):397-403.
1998: Annemieke Verstuyf; Lieve Verlinden; Hugo Van Baelen; Katrien Sabbe; C D'Hallewyn; Pierre J De Clercq; Maurits Vandewalle; Roger Bouillon
The biological activity of nonsteroidal vitamin D hormone analogs lacking both the C- and D-rings.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1998;13(4):549-58.
1997: Lieve Verlinden; Annemieke Verstuyf; Chantal Mathieu; B K Tan; Roger Bouillon
Differentiation induction of HL60 cells by 1,25(OH)2D3, all trans retinoic acid, rTGF-beta2 and their combinations.
The Journal of steroid biochemistry and molecular biology 1997;60(1-2):87-97.
1995: Roger Bouillon; Annemieke Verstuyf; Lieve Verlinden; K Allewaert; D Branisteanu; Chantal Mathieu; H van Baelen
Non-hypercalcemic pharmacological aspects of vitamin D analogs.
Biochemical pharmacology 1995;50(5):577-83.
1995: Annemieke Verstuyf; Chantal Mathieu; Lieve Verlinden; Mark Waer; B K Tan; Roger Bouillon
Differentiation induction of human leukemia cells (HL60) by a combination of 1,25-dihydroxyvitamin D3 and retinoic acid (all trans or 9-cis).
The Journal of steroid biochemistry and molecular biology 1995;53(1-6):431-41.