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Nico Vermeulen

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Sanja Dragovic; Patrina Gunness; Magnus Ingelman-Sundberg; Nico P E Vermeulen; Jan N M Commandeur
Characterization of human cytochrome P450s involved in the bioactivation of clozapine.
Hilmi Orhan; Altan Sahin; Gonul Sahin; Ulku Aypar; Nico P E Vermeulen
Urinary lipid and protein oxidation products upon halothane, isoflurane, or sevoflurane anesthesia in humans: potential biomarkers for a subclinical nephrotoxicity.
Jolanda S van Leeuwen; Nico P E Vermeulen; J Chris Vos
Yeast as a humanized model organism for biotransformation-related toxicity.

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2013: Sanja Dragovic; Patrina Gunness; Magnus Ingelman-Sundberg; Nico P E Vermeulen; Jan N M Commandeur
Characterization of human cytochrome P450s involved in the bioactivation of clozapine.
Drug metabolism and disposition: the biological fate of chemicals 2013;41(3):651-8.
2013: Hilmi Orhan; Altan Sahin; Gonul Sahin; Ulku Aypar; Nico P E Vermeulen
Urinary lipid and protein oxidation products upon halothane, isoflurane, or sevoflurane anesthesia in humans: potential biomarkers for a subclinical nephrotoxicity.
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals 2013;18(1):73-81.
2012: Jolanda S van Leeuwen; Nico P E Vermeulen; J Chris Vos
Yeast as a humanized model organism for biotransformation-related toxicity.
Current drug metabolism 2012;13(10):1464-75.
2012: Jan Simon Boerma; Sanja Dragovic; Nico P E Vermeulen; Jan N M Commandeur
Mass spectrometric characterization of protein adducts of multiple P450-dependent reactive intermediates of diclofenac to human glutathione-S-transferase P1-1.
Chemical research in toxicology 2012;25(11):2532-41.
2012: Stephanie B A de Beer; Daan P Geerke; Chris Oostenbrink; Harini Venkataraman; Nico P E Vermeulen
Free energy calculations give insight into the stereoselective hydroxylation of α-ionones by engineered cytochrome P450 BM3 mutants.
Journal of chemical information and modeling 2012;52(8):2139-48.
2012: Daan R W Verstappen; Nico P E Vermeulen; Alex Fidder; Albert G Hulst; Daan Noort
Interactions of organophosphates with keratins in the cornified epithelium of human skin.
Chemico-biological interactions 2012;197(2-3):93-102.
2012: Harini Venkataraman; Nico P E Vermeulen; Stephanie B A de Beer; Laura A H van Bergen; Nick van Essen; Daan P Geerke; Jan N M Commandeur
A single active site mutation inverts stereoselectivity of 16-hydroxylation of testosterone catalyzed by engineered cytochrome P450 BM3.
Chembiochem : a European journal of chemical biology 2012;13(4):520-3.
2012: Jolanda S van Leeuwen; Nico P E Vermeulen; Betül Unlü; Jan C Vos
Differential involvement of mitochondrial dysfunction, cytochrome P450 activity, and active transport in the toxicity of structurally related NSAIDs.
Toxicology in vitro : an international journal published in association with BIBRA 2012;26(2):197-205.
2012: Stephanie B A de Beer; F Matthias Bickelhaupt; Jan N M Commandeur; Célia Fonseca Guerra; Karlijn Keijzer; Vanina Rea; Laura A H van Bergen; Harini Venkataraman; Nico P E Vermeulen; Daan P Geerke
The role of protein plasticity in computational rationalization studies on regioselectivity in testosterone hydroxylation by cytochrome P450 BM3 mutants.
Current drug metabolism 2012;13(2):155-66.
2011: Vanina Rea; Nico P E Vermeulen; Jan Simon Boerma; Frans J J de Kanter; Sanja Dragovic; Jan N M Commandeur
Role of residue 87 in the activity and regioselectivity of clozapine metabolism by drug-metabolizing CYP102A1 M11H: application for structural characterization of clozapine GSH conjugates.
Drug metabolism and disposition: the biological fate of chemicals 2011;39(12):2411-20.
2011: Jolanda S van Leeuwen; Nico P E Vermeulen; Jan C Vos
Involvement of the pleiotropic drug resistance response, protein kinase C signaling, and altered zinc homeostasis in resistance of Saccharomyces cerevisiae to diclofenac.
Applied and environmental microbiology 2011;77(17):5973-80.
2011: Jelle Reinen; John Saunders; Lifang Sun; Jolanda S van Leeuwen; Nico P E Vermeulen; Caroline J Decker; Peter D J Grootenhuis; Yongmin Li; Jan N M Commandeur
Efficient screening of cytochrome P450 BM3 mutants for their metabolic activity and diversity toward a wide set of drug-like molecules in chemical space.
Drug metabolism and disposition: the biological fate of chemicals 2011;39(9):1568-76.
2011: Eduardo Vottero; Maarten Honing; Jeroen Lastdrager; Vanina Rea; Nico P E Vermeulen; Jan N M Commandeur
Role of residue 87 in substrate selectivity and regioselectivity of drug-metabolizing cytochrome P450 CYP102A1 M11.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2011;16(6):899-912.
2011: Lisa Fredriksson; Bram Herpers; Giulia Benedetti; Quraisha Matadin; Jordi C Puigvert; Hans de Bont; Sanja Dragovic; Nico P E Vermeulen; Jan N M Commandeur; Erik Danen; Marjo de Graauw; Bob van de Water
Diclofenac inhibits tumor necrosis factor-α-induced nuclear factor-κB activation causing synergistic hepatocyte apoptosis.
Hepatology (Baltimore, Md.) 2011;53(6):2027-41.
2011: Hilmi Orhan; Nico P E Vermeulen
Conventional and novel approaches in generating and characterization of reactive intermediates from drugs/drug candidates.
Current drug metabolism 2011;12(4):383-94.
2011: Jolanda S van Leeuwen; Rick Orij; Marijke A H Luttik; Gertien Smits; Nico P E Vermeulen; Jan C Vos
Subunits Rip1p and Cox9p of the respiratory chain contribute to diclofenac-induced mitochondrial dysfunction.
Microbiology (Reading, England) 2011;157(Pt 3):685-94.
2011: Jolanda S van Leeuwen; Galvin Vredenburg; Sanja Dragovic; T F Jennifer Tjong; Jan C Vos; Nico P E Vermeulen
Metabolism related toxicity of diclofenac in yeast as model system.
Toxicology letters 2011;200(3):162-8.
2011: Jelle Reinen; Suilan Ferman; Eduardo Vottero; Nico P E Vermeulen; Jan N M Commandeur
Application of a fluorescence-based continuous-flow bioassay to screen for diversity of cytochrome P450 BM3 mutant libraries.
Journal of biomolecular screening 2011;16(2):239-50.
2011: Jelle Reinen; Livia L Kalma; Selina Begheijn; Ferry Heus; Jan N M Commandeur; Nico P E Vermeulen
Application of cytochrome P450 BM3 mutants as biocatalysts for the profiling of estrogen receptor binding metabolites of the mycotoxin zearalenone.
Xenobiotica; the fate of foreign compounds in biological systems 2011;41(1):59-70.
2010: Jelle Reinen; Marc Suter; Rik I L Eggen; Mariana F Fernandez; Hannu Kiviranta; A Christiane Vögeli; Nico P E Vermeulen
Endocrine disrupting chemicals-Linking internal exposure to vitellogenin levels and ovotestis in Abramis brama from Dutch surface waters.
Environmental toxicology and pharmacology 2010;30(3):209-23.
2010: Sanja Dragovic; Jan Simon Boerma; Laura van Bergen; Nico P E Vermeulen; Jan N M Commandeur
Role of human glutathione S-transferases in the inactivation of reactive metabolites of clozapine.
Chemical research in toxicology 2010;23(9):1467-76.
2010: Vasanthanathan Poongavanam; Lars Olsen; Flemming Steen Jørgensen; Nico P E Vermeulen; Chris Oostenbrink
Computational prediction of binding affinity for CYP1A2-ligand complexes using empirical free energy calculations.
Drug metabolism and disposition: the biological fate of chemicals 2010;38(8):1347-54.
2010: Eva Stjernschantz; Jelle Reinen; Walter Meinl; Beena J George; Hansruedi Glatt; Nico P E Vermeulen; Chris Oostenbrink
Comparison of murine and human estrogen sulfotransferase inhibition in vitro and in silico--implications for differences in activity, subunit dimerization and substrate inhibition.
Molecular and cellular endocrinology 2010;317(1-2):127-40.
2010: Jon S B de Vlieger; Ard J Kolkman; Kirsten A M Ampt; Jan N M Commandeur; Nico P E Vermeulen; Jeroen Kool; Sybren S Wijmenga; Wilfried M A Niessen; Hubertus Irth; Maarten Honing
Determination and identification of estrogenic compounds generated with biosynthetic enzymes using hyphenated screening assays, high resolution mass spectrometry and off-line NMR.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2010;878(7-8):667-74.
2010: Stephanie B A de Beer; Nico P E Vermeulen; Chris Oostenbrink
The role of water molecules in computational drug design.
Current topics in medicinal chemistry 2010;10(1):55-66.
2009: Vasanthanathan Poongavanam; Olivier Taboureau; Chris Oostenbrink; Nico P E Vermeulen; Lars Olsen; Flemming Steen Jørgensen
Classification of cytochrome P450 1A2 inhibitors and noninhibitors by machine learning techniques.
Drug metabolism and disposition: the biological fate of chemicals 2009;37(3):658-64.
2009: Vasanthanathan Poongavanam; Jozef Hritz; Olivier Taboureau; Lars Olsen; Flemming Steen Jørgensen; Nico P E Vermeulen; Chris Oostenbrink
Virtual screening and prediction of site of metabolism for cytochrome P450 1A2 ligands.
Journal of chemical information and modeling 2009;49(1):43-52.
2008: Regina Appiah-Opong; Jan N M Commandeur; Civianny Axson; Nico P E Vermeulen
Interactions between cytochromes P450, glutathione S-transferases and Ghanaian medicinal plants.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2008;46(12):3598-603.
2008: Micaela C Damsten; Jon S B de Vlieger; Wilfried M A Niessen; Hubertus Irth; Nico P E Vermeulen; Jan N M Commandeur
Trimethoprim: novel reactive intermediates and bioactivation pathways by cytochrome p450s.
Chemical research in toxicology 2008;21(11):2181-7.
2008: Regina Appiah-Opong; Iwan J P De Esch; Jan N M Commandeur; Mayagustina Andarini; Nico P E Vermeulen
Structure-activity relationships for the inhibition of recombinant human cytochromes P450 by curcumin analogues.
European journal of medicinal chemistry 2008;43(8):1621-31.
2008: Jelle Reinen; Jeroen Kool; Nico P E Vermeulen
Reversed-phase liquid chromatography coupled on-line to estrogen receptor bioaffinity detection based on fluorescence polarization.
Analytical and bioanalytical chemistry 2008;390(8):1987-98.
2008: Eva Stjernschantz; Barbara M A van Vugt-Lussenburg; Alois Bonifacio; Stephanie B A de Beer; Gert van der Zwan; Cees Gooijer; Jan N M Commandeur; Nico P E Vermeulen; Chris Oostenbrink
Structural rationalization of novel drug metabolizing mutants of cytochrome P450 BM3.
Proteins 2008;71(1):336-52.
2008: Micaela C Damsten; Barbara M A van Vugt-Lussenburg; Tineke Zeldenthuis; Jon S B de Vlieger; Jan N M Commandeur; Nico P E Vermeulen
Application of drug metabolising mutants of cytochrome P450 BM3 (CYP102A1) as biocatalysts for the generation of reactive metabolites.
Chemico-biological interactions 2008;171(1):96-107.
2008: Rosalind E Jenkins; Neil R Kitteringham; Chris Goldring; Samantha M J Dowdall; Jane Hamlett; Catherine S Lane; Jan-Simon Boerma; Nico P E Vermeulen; B Kevin Park
Glutathione-S-transferase pi as a model protein for the characterisation of chemically reactive metabolites.
Proteomics 2008;8(2):301-15.
2008: Alois Bonifacio; Diego Millo; Peter H J Keizers; Roald Boegschoten; Jan N M Commandeur; Nico P E Vermeulen; Cees Gooijer; Gert van der Zwan
Active-site structure, binding and redox activity of the heme-thiolate enzyme CYP2D6 immobilized on coated Ag electrodes: a surface-enhanced resonance Raman scattering study.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2008;13(1):85-96.
2007: Jeroen Kool; André van Marle; Saskia Hulscher; Maurice Selman; Dick J van Iperen; Klaas Van Altena; Michel Gillard; Remko A Bakker; Hubertus Irth; Rob Leurs; Nico P E Vermeulen
A flow-through fluorescence polarization detection system for measuring GPCR-mediated modulation of cAMP production.
Journal of biomolecular screening 2007;12(8):1074-83.
2007: Johannes S Hoos; Micaela C Damsten; Jon S B de Vlieger; Jan N M Commandeur; Nico P E Vermeulen; Wilfried M A Niessen; Henk Lingeman; Hubertus Irth
Automated detection of covalent adducts to human serum albumin by immunoaffinity chromatography, on-line solution phase digestion and liquid chromatography-mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2007;859(2):147-56.
2007: Jeroen Kool; Sebastiaan M van Liempd; Stefan Harmsen; Joran Beckman; Danny A van Elswijk; Jan N M Commandeur; Hubertus Irth; Nico P E Vermeulen
Cytochrome P450 bio-affinity detection coupled to gradient HPLC: on-line screening of affinities to cytochrome P4501A2 and 2D6.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2007;858(1-2):49-58.
2007: Anna Martínez-Cabot; Anna Morató; Jan N M Commandeur; Nico P E Vermeulen; Angel Messeguer
In vitro bioactivation of 3-(N-phenylamino)propane-1,2-diol by human and rat liver microsomes and recombinant P450 enzymes. Implications for toxic oil syndrome.
Chemical research in toxicology 2007;20(8):1218-24.
2007: Micaela C Damsten; Jan N M Commandeur; Alex Fidder; Albert G Hulst; Daan J Touw; Daan Noort; Nico P E Vermeulen
Liquid chromatography/tandem mass spectrometry detection of covalent binding of acetaminophen to human serum albumin.
Drug metabolism and disposition: the biological fate of chemicals 2007;35(8):1408-17.
2007: Chris de Graaf; Chris Oostenbrink; Peter H J Keizers; Barbara M A van Vugt-Lussenburg; Jan N M Commandeur; Nico P E Vermeulen
Free energies of binding of R- and S-propranolol to wild-type and F483A mutant cytochrome P450 2D6 from molecular dynamics simulations.
European biophysics journal : EBJ 2007;36(6):589-99.
2007: Regina Appiah-Opong; Jan N M Commandeur; Barbara M A van Vugt-Lussenburg; Nico P E Vermeulen
Inhibition of human recombinant cytochrome P450s by curcumin and curcumin decomposition products.
Toxicology 2007;235(1-2):83-91.
2007: Jeroen Kool; Sebastiaan M van Liempd; Stefan Harmsen; Tim Schenk; Hubertus Irth; Jan N M Commandeur; Nico P E Vermeulen
An on-line post-column detection system for the detection of reactive-oxygen-species-producing compounds and antioxidants in mixtures.
Analytical and bioanalytical chemistry 2007;388(4):871-9.
2007: Alois Bonifacio; André R Groenhof; Peter H J Keizers; Chris de Graaf; Jan N M Commandeur; Nico P E Vermeulen; Andreas W Ehlers; Koop Lammertsma; Cees Gooijer; Gert van der Zwan
Altered spin state equilibrium in the T309V mutant of cytochrome P450 2D6: a spectroscopic and computational study.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2007;12(5):645-54.
2007: Jeroen Kool; Mark Eggink; Huub van Rossum; Sebastiaan M van Liempd; Danny A van Elswijk; Hubertus Irth; Jan N M Commandeur; John Meerman; Nico P E Vermeulen
Online biochemical detection of glutathione-S-transferase P1-specific inhibitors in complex mixtures.
Journal of biomolecular screening 2007;12(3):396-405.
2007: Jeroen Kool; Sebastiaan M van Liempd; Huub van Rossum; Danny A van Elswijk; Hubertus Irth; Jan N M Commandeur; Nico P E Vermeulen
Development of three parallel cytochrome P450 enzyme affinity detection systems coupled on-line to gradient high-performance liquid chromatography.
Drug metabolism and disposition: the biological fate of chemicals 2007;35(4):640-8.
2007: K Anton Feenstra; Evgeni B. Starikov; Vlada B Urlacher; Jan N M Commandeur; Nico P E Vermeulen
Combining substrate dynamics, binding statistics, and energy barriers to rationalize regioselective hydroxylation of octane and lauric acid by CYP102A1 and mutants.
Protein science : a publication of the Protein Society 2007;16(3):420-31.
2007: Alois Bonifacio; Peter H J Keizers; Nico P E Vermeulen; Jan N M Commandeur; Cees Gooijer; Gert van der Zwan
Surface-enhanced resonance Raman scattering of cytochrome P450-2D6 on coated silver hydrosols.
Langmuir : the ACS journal of surfaces and colloids 2007;23(4):1860-6.
2007: Barbara M A van Vugt-Lussenburg; Eva Stjernschantz; Jeroen Lastdrager; Chris Oostenbrink; Nico P E Vermeulen; Jan N M Commandeur
Identification of critical residues in novel drug metabolizing mutants of cytochrome P450 BM3 using random mutagenesis.
Journal of medicinal chemistry 2007;50(3):455-61.
2007: Chris de Graaf; Chris Oostenbrink; Peter H J Keizers; Barbara M A van Vugt-Lussenburg; Robert A B van Waterschoot; Richard A Tschirret-Guth; Jan N M Commandeur; Nico P E Vermeulen
Molecular modeling-guided site-directed mutagenesis of cytochrome P450 2D6.
Current drug metabolism 2007;8(1):59-77.
2006: K Anton Feenstra; Karin Hofstetter; Rolien Bosch; Andreas Schmid; Jan N M Commandeur; Nico P E Vermeulen
Enantioselective substrate binding in a monooxygenase protein model by molecular dynamics and docking.
Biophysical journal 2006;91(9):3206-16.
2006: Jelle Reinen; Eveline Vriese; Hansruedi Glatt; Nico P E Vermeulen
Development and validation of a fluorescence HPLC-based screening assay for inhibition of human estrogen sulfotransferase.
Analytical biochemistry 2006;357(1):85-92.
2006: Eva Stjernschantz; John Marelius; Carmen Medina; Micael Jacobsson; Nico P E Vermeulen; Chris Oostenbrink
Are automated molecular dynamics simulations and binding free energy calculations realistic tools in lead optimization? An evaluation of the linear interaction energy (LIE) method.
Journal of chemical information and modeling 2006;46(5):1972-83.
2006: Peter H J Keizers; B R Van Dijk; Chris de Graaf; Barbara M A van Vugt-Lussenburg; Nico P E Vermeulen; Jan N M Commandeur
Metabolism of N-substituted 7-methoxy-4-(aminomethyl) -coumarins by cytochrome P450 2D6 mutants and the indication of additional substrate interaction points.
Xenobiotica; the fate of foreign compounds in biological systems 2006;36(9):763-71.
2006: Sebastiaan M van Liempd; Jeroen Kool; Wilfried M A Niessen; D E van Elswijk; Hubertus Irth; Nico P E Vermeulen
On-line formation, separation, and estrogen receptor affinity screening of cytochrome P450-derived metabolites of selective estrogen receptor modulators.
Drug metabolism and disposition: the biological fate of chemicals 2006;34(9):1640-9.
2006: Hilmi Orhan; Hande Gurer-Orhan; E Vriese; Nico P E Vermeulen; John Meerman
Application of lipid peroxidation and protein oxidation biomarkers for oxidative damage in mammalian cells. A comparison with two fluorescent probes.
Toxicology in vitro : an international journal published in association with BIBRA 2006;20(6):1005-13.
2006: Barbara M A van Vugt-Lussenburg; Micaela C Damsten; Dianne M Maasdijk; Nico P E Vermeulen; Jan N M Commandeur
Heterotropic and homotropic cooperativity by a drug-metabolising mutant of cytochrome P450 BM3.
Biochemical and biophysical research communications 2006;346(3):810-8.
2006: R C A Onderwater; A E Rettie; Jan N M Commandeur; Nico P E Vermeulen
Bioactivation of N-substituted N'-(4-imidazole-ethyl)thioureas by human FMO1 and FMO3.
Xenobiotica; the fate of foreign compounds in biological systems 2006;36(7):645-57.
2006: Jeroen Kool; Rawi Ramautar; Sebastiaan M van Liempd; Joran Beckman; Frans J J de Kanter; John Meerman; Tim Schenk; Hubertus Irth; Jan N M Commandeur; Nico P E Vermeulen
Rapid on-line profiling of estrogen receptor binding metabolites of tamoxifen.
Journal of medicinal chemistry 2006;49(11):3287-92.
2006: Alois Bonifacio; Peter H J Keizers; Jan N M Commandeur; Nico P E Vermeulen; Bruno Robert; Cees Gooijer; Gert van der Zwan
Binding of bufuralol, dextromethorphan, and 3,4-methylenedioxymethylamphetamine to wild-type and F120A mutant cytochrome P450 2D6 studied by resonance Raman spectroscopy.
Biochemical and biophysical research communications 2006;343(3):772-9.
2006: Chris de Graaf; Chris Oostenbrink; Peter H J Keizers; Tushar van der Wijst; Aldo Jongejan; Nico P E Vermeulen
Catalytic site prediction and virtual screening of cytochrome P450 2D6 substrates by consideration of water and rescoring in automated docking.
Journal of medicinal chemistry 2006;49(8):2417-30.
2006: Robert A B van Waterschoot; Peter H J Keizers; Chris de Graaf; Nico P E Vermeulen; Richard A Tschirret-Guth
Topological role of cytochrome P450 2D6 active site residues.
Archives of biochemistry and biophysics 2006;447(1):53-8.
2006: Nico P E Vermeulen
Human-based alternatives to animal experiments: is 'Replacement' credible?
Environmental toxicology and pharmacology 2006;21(2):119.
2006: Aike Stortelder; Peter H J Keizers; Chris Oostenbrink; Chris de Graaf; Petra De Kruijf; Nico P E Vermeulen; Cees Gooijer; Jan N M Commandeur; Gert van der Zwan
Binding of 7-methoxy-4-(aminomethyl)-coumarin to wild-type and W128F mutant cytochrome P450 2D6 studied by time-resolved fluorescence spectroscopy.
The Biochemical journal 2006;393(Pt 3):635-43.
2005: Peter H J Keizers; Loek H M Schraven; Chris de Graaf; Mats Hidestrand; Magnus Ingelman-Sundberg; Ben R van Dijk; Nico P E Vermeulen; Jan N M Commandeur
Role of the conserved threonine 309 in mechanism of oxidation by cytochrome P450 2D6.
Biochemical and biophysical research communications 2005;338(2):1065-74.
2005: Marola M H van Lipzig; Jan N M Commandeur; Frans J J de Kanter; Micaela C Damsten; Nico P E Vermeulen; Evelina Maat; Ed J Groot; Abraham Brouwer; Monique H A Kester; Theo J Visser; John Meerman
Bioactivation of dibrominated biphenyls by cytochrome P450 activity to metabolites with estrogenic activity and estrogen sulfotransferase inhibition capacity.
Chemical research in toxicology 2005;18(11):1691-700.
2005: Barbara M A Lussenburg; Peter H J Keizers; Chris de Graaf; Mats Hidestrand; Magnus Ingelman-Sundberg; Nico P E Vermeulen; Jan N M Commandeur
The role of phenylalanine 483 in cytochrome P450 2D6 is strongly substrate dependent.
Biochemical pharmacology 2005;70(8):1253-61.
2005: Peter H J Keizers; Chris de Graaf; Frans J J de Kanter; Chris Oostenbrink; K Anton Feenstra; Jan N M Commandeur; Nico P E Vermeulen
Metabolic regio- and stereoselectivity of cytochrome P450 2D6 towards 3,4-methylenedioxy-N-alkylamphetamines: in silico predictions and experimental validation.
Journal of medicinal chemistry 2005;48(19):6117-27.
2005: Jeroen Kool; Sebastiaan M van Liempd; Rawi Ramautar; Tim Schenk; John Meerman; Hubertus Irth; Jan N M Commandeur; Nico P E Vermeulen
Development of a novel cytochrome p450 bioaffinity detection system coupled online to gradient reversed-phase high-performance liquid chromatography.
Journal of biomolecular screening 2005;10(5):427-36.
2005: Barbara M A Lussenburg; Lloyd C Babel; Nico P E Vermeulen; Jan N M Commandeur
Evaluation of alkoxyresorufins as fluorescent substrates for cytochrome P450 BM3 and site-directed mutants.
Analytical biochemistry 2005;341(1):148-55.
2005: Sebastiaan M van Liempd; Jeroen Kool; Jelle Reinen; Tim Schenk; John Meerman; Hubertus Irth; Nico P E Vermeulen
Development and validation of a microsomal online cytochrome P450 bioreactor coupled to solid-phase extraction and reversed-phase liquid chromatography.
Journal of chromatography. A 2005;1075(1-2):205-12.
2005: Chris de Graaf; Nico P E Vermeulen; K Anton Feenstra
Cytochrome p450 in silico: an integrative modeling approach.
Journal of medicinal chemistry 2005;48(8):2725-55.
2005: Chris de Graaf; Pavel Pospisil; Wouter Pos; Gerd Folkers; Nico P E Vermeulen
Binding mode prediction of cytochrome p450 and thymidine kinase protein-ligand complexes by consideration of water and rescoring in automated docking.
Journal of medicinal chemistry 2005;48(7):2308-18.
2005: R C A Onderwater; Jan N M Commandeur; Martijn Rooseboom; Nico P E Vermeulen
Uptake-toxicity relationships of a series of N-substituted N'-(4-imidazole-ethyl)thiourea in precision-cut rat liver slices.
Xenobiotica; the fate of foreign compounds in biological systems 2005;35(4):391-404.
2005: Marola M H van Lipzig; Nico P E Vermeulen; Albrecht Seidel; Heinz Frank; Renato Gusinu; Juliette Legler; John Meerman
Formation of estrogenic metabolites of benzo[a]pyrene and chrysene by cytochrome P450 activity and their combined and supra-maximal estrogenic activity.
Environmental toxicology and pharmacology 2005;19(1):41-55.
2005: Aldo Jongejan; Chris de Graaf; Nico P E Vermeulen; Rob Leurs; Iwan J P De Esch
The role and application of in silico docking in chemical genomics research.
Methods in molecular biology (Clifton, N.J.) 2005;310():63-91.
2004: Hilmi Orhan; Berry van Holland; Betty Krab; Janine Moeken; Nico P E Vermeulen; Peter Hollander; John Meerman
Evaluation of a multi-parameter biomarker set for oxidative damage in man: increased urinary excretion of lipid, protein and DNA oxidation products after one hour of exercise.
Free radical research 2004;38(12):1269-79.
2004: Peter H J Keizers; Barbara M A Lussenburg; Chris de Graaf; Letty M Mentink; Nico P E Vermeulen; Jan N M Commandeur
Influence of phenylalanine 120 on cytochrome P450 2D6 catalytic selectivity and regiospecificity: crucial role in 7-methoxy-4-(aminomethyl)-coumarin metabolism.
Biochemical pharmacology 2004;68(11):2263-71.
2004: Susana Yenes; Jan N M Commandeur; Nico P E Vermeulen; Angel Messeguer
In vitro biotransformation of 3,4-dihydro-6-hydroxy-2,2-dimethyl-7-methoxy-1(2H)-benzopyran (CR-6), a potent lipid peroxidation inhibitor and nitric oxide scavenger, in rat liver microsomes.
Chemical research in toxicology 2004;17(7):904-13.
2004: R C A Onderwater; Jan N M Commandeur; Nico P E Vermeulen
Comparative cytotoxicity of N-substituted N'-(4-imidazole-ethyl)thiourea in precision-cut rat liver slices.
Toxicology 2004;197(2):81-91.
2004: Hilmi Orhan; Jan N M Commandeur; Gonul Sahin; Ulku Aypar; altan sahin; Nico P E Vermeulen
Use of 19F-nuclear magnetic resonance and gas chromatography-electron capture detection in the quantitative analysis of fluorine-containing metabolites in urine of sevoflurane-anaesthetized patients.
Xenobiotica; the fate of foreign compounds in biological systems 2004;34(3):301-16.
2004: Martijn Rooseboom; Jan N M Commandeur; Nico P E Vermeulen
Enzyme-catalyzed activation of anticancer prodrugs.
Pharmacological reviews 2004;56(1):53-102.
2004: Marola M H van Lipzig; Antonius Marinus ter Laak; Aldo Jongejan; Nico P E Vermeulen; Mirjam M C Wamelink; Daan Geerke; John Meerman
Prediction of ligand binding affinity and orientation of xenoestrogens to the estrogen receptor by molecular dynamics simulations and the linear interaction energy method.
Journal of medicinal chemistry 2004;47(4):1018-30.
2004: Hilmi Orhan; Nico P E Vermeulen; Cornelis Tump; Herman Zappey; John Meerman
Simultaneous determination of tyrosine, phenylalanine and deoxyguanosine oxidation products by liquid chromatography-tandem mass spectrometry as non-invasive biomarkers for oxidative damage.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2004;799(2):245-54.
2003: Jennifer Venhorst; Antonius Marinus ter Laak; Moira Meijer; Ineke van de Wetering; Jan N M Commandeur; Martijn Rooseboom; Nico P E Vermeulen
Modeling and molecular dynamics of glutamine transaminase K/cysteine conjugate beta-lyase.
Journal of molecular graphics & modelling 2003;22(1):55-70.
2003: Ron van der Oost; Jonny Beyer; Nico P E Vermeulen
Fish bioaccumulation and biomarkers in environmental risk assessment: a review.
Environmental toxicology and pharmacology 2003;13(2):57-149.
2003: Jennifer Venhorst; Antonius Marinus ter Laak; Jan N M Commandeur; Yoshihiko Funae; Toyoko Hiroi; Nico P E Vermeulen
Homology modeling of rat and human cytochrome P450 2D (CYP2D) isoforms and computational rationalization of experimental ligand-binding specificities.
Journal of medicinal chemistry 2003;46(1):74-86.
2003: Nico P E Vermeulen
Prediction of drug metabolism: the case of cytochrome P450 2D6.
Current topics in medicinal chemistry 2003;3(11):1227-39.
2003: Jennifer Venhorst; Martijn Rooseboom; Nico P E Vermeulen; Jan N M Commandeur
Studies on the inhibition of human cytochromes P450 by selenocysteine Se-conjugates.
Xenobiotica; the fate of foreign compounds in biological systems 2003;33(1):57-72.
2002: Peter A C 't Hoen; Ruud Out; Jan N M Commandeur; Nico P E Vermeulen; F H D van Batenburg; Muthiah Manoharan; Theo Van berkel; Erik A L Biessen; Martin K Bijsterbosch
Selection of antisense oligodeoxynucleotides against glutathione S-transferase Mu.
RNA (New York, N.Y.) 2002;8(12):1572-83.
2002: Martijn Rooseboom; Nico P E Vermeulen; Fatma Durgut; Jan N M Commandeur
Comparative study on the bioactivation mechanisms and cytotoxicity of Te-phenyl-L-tellurocysteine, Se-phenyl-L-selenocysteine, and S-phenyl-L-cysteine.
Chemical research in toxicology 2002;15(12):1610-8.
2002: Martijn Rooseboom; Nico P E Vermeulen; Ed J Groot; Jan N M Commandeur
Tissue distribution of cytosolic beta-elimination reactions of selenocysteine Se-conjugates in rat and human.
Chemico-biological interactions 2002;140(3):243-64.
2002: Erna M Hissink; Jan J P Bogaards; Jan N M Commandeur; Andreas P Freidig; Nico P E Vermeulen; Peter J van Bladeren
The use of in vitro metabolic parameters and physiologically based pharmacokinetic (PBPK) modeling to explore the risk assessment of trichloroethylene.
Environmental toxicology and pharmacology 2002;11(3-4):259-71.
2002: Ivonne M C M Rietjens; Nico P E Vermeulen
[In Process Citation].
Environmental toxicology and pharmacology 2002;11(3-4):147.
2002: Martijn Rooseboom; Gerben Schaaf; Jan N M Commandeur; Nico P E Vermeulen; Johanna Fink-Gremmels
Beta-lyase-dependent attenuation of cisplatin-mediated toxicity by selenocysteine Se-conjugates in renal tubular cell lines.
The Journal of pharmacology and experimental therapeutics 2002;301(3):884-92.
2002: Peter A C 't Hoen; Martijn Rooseboom; Martin K Bijsterbosch; Theo Van berkel; Nico P E Vermeulen; Jan N M Commandeur
Induction of glutathione-S-transferase mRNA levels by chemopreventive selenocysteine Se-conjugates.
Biochemical pharmacology 2002;63(10):1843-9.
2002: Peter A C 't Hoen; Bram-Sieben Rosema; Jan N M Commandeur; Nico P E Vermeulen; Muthiah Manoharan; Theo Van berkel; Erik A L Biessen; Martin K Bijsterbosch
Selection of effective antisense oligodeoxynucleotides with a green fluorescent protein-based assay. Discovery of selective and potent inhibitors of glutathione S-transferase Mu expression.
European journal of biochemistry / FEBS 2002;269(10):2574-83.
2002: Martijn Rooseboom; Nico P E Vermeulen; Jan N M Commandeur
Enzymatic pathways of beta elimination of chemopreventive selenocysteine Se conjugates.
Methods in enzymology 2002;348():191-200.
2001: P A Hoen; Martin K Bijsterbosch; Theo Van berkel; Nico P E Vermeulen; Jan N M Commandeur
Midazolam is a phenobarbital-like cytochrome p450 inducer in rats.
The Journal of pharmacology and experimental therapeutics 2001;299(3):921-7.
2001: Martijn Rooseboom; Nico P E Vermeulen; N van Hemert; Jan N M Commandeur
Bioactivation of chemopreventive selenocysteine Se-conjugates and related amino acids by amino acid oxidases novel route of metabolism of selenoamino acids.
Chemical research in toxicology 2001;14(8):996-1005.
2001: Hilmi Orhan; Nico P E Vermeulen; G Sahin; Jan N M Commandeur
Characterization of thioether compounds formed from alkaline degradation products of enflurane.
Anesthesiology 2001;95(1):165-75.
2001: Jan N M Commandeur; Martijn Rooseboom; Nico P E Vermeulen
Chemistry and biological activity of novel selenium-containing compounds.
Advances in experimental medicine and biology 2001;500():105-12.
2001: J G Bessems; Nico P E Vermeulen
Paracetamol (acetaminophen)-induced toxicity: molecular and biochemical mechanisms, analogues and protective approaches.
Critical reviews in toxicology 2001;31(1):55-138.
2001: Martijn Rooseboom; Jan N M Commandeur; G C Floor; A E Rettie; Nico P E Vermeulen
Selenoxidation by flavin-containing monooxygenases as a novel pathway for beta-elimination of selenocysteine Se-conjugates.
Chemical research in toxicology 2001;14(1):127-34.
2000: Jennifer Venhorst; R C A Onderwater; John Meerman; Nico P E Vermeulen; Jan N M Commandeur
Evaluation of a novel high-throughput assay for cytochrome P450 2D6 using 7-methoxy-4-(aminomethyl)-coumarin.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2000;12(2):151-8.
2000: Jennifer Venhorst; R C A Onderwater; John Meerman; Jan N M Commandeur; Nico P E Vermeulen
Influence of N-substitution of 7-methoxy-4-(aminomethyl)-coumarin on cytochrome P450 metabolism and selectivity.
Drug metabolism and disposition: the biological fate of chemicals 2000;28(12):1524-32.
2000: P A Hoen; Jan N M Commandeur; Nico P E Vermeulen; Theo Van berkel; Martin K Bijsterbosch
Selective induction of cytochrome P450 3A1 by dexamethasone in cultured rat hepatocytes: analysis with a novel reverse transcriptase-polymerase chain reaction assay section sign.
Biochemical pharmacology 2000;60(10):1509-18.
2000: AM Hissink; Lars W Wormhoudt; Philip J Sherratt; J D Hayes; Jan N M Commandeur; Nico P E Vermeulen; Peter J van Bladeren
A physiologically-based pharmacokinetic(PB-PK) model for ethylene dibromide: relevance of extrahepatic metabolism.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2000;38(8):707-16.
2000: Martijn Rooseboom; Nico P E Vermeulen; I Andreadou; Jan N M Commandeur
Evaluation of the kinetics of beta-elimination reactions of selenocysteine Se-conjugates in human renal cytosol: possible implications for the use as kidney selective prodrugs.
The Journal of pharmacology and experimental therapeutics 2000;294(2):762-9.
2000: Jan N M Commandeur; I Andreadou; Martijn Rooseboom; M Out; L J de Leur; Ed J Groot; Nico P E Vermeulen
Bioactivation of selenocysteine Se-conjugates by a highly purified rat renal cysteine conjugate beta-lyase/glutamine transaminase K.
The Journal of pharmacology and experimental therapeutics 2000;294(2):753-61.
2000: Michel Kranendonk; António Laires; Jose Rueff; W R Estabrook; Nico P E Vermeulen
Heterologous expression of xenobiotic mammalian-metabolizing enzymes in mutagenicity tester bacteria: an update and practical considerations.
Critical reviews in toxicology 2000;30(3):287-306.
2000: T Lightfoot; S Wynne Ellis; J Mahling; MJ Ackland; F E Blaney; GJ Bijloo; Marcel J de Groot; Nico P E Vermeulen; G M Blackburn; Martin S Lennard; Geoffrey T Tucker
Regioselective hydroxylation of debrisoquine by cytochrome P4502D6: implications for active site modelling.
Xenobiotica; the fate of foreign compounds in biological systems 2000;30(3):219-33.
1999: R C A Onderwater; Jennifer Venhorst; Jan N M Commandeur; Nico P E Vermeulen
Design, synthesis, and characterization of 7-methoxy-4-(aminomethyl)coumarin as a novel and selective cytochrome P450 2D6 substrate suitable for high-throughput screening.
Chemical research in toxicology 1999;12(7):555-9.
1999: R C A Onderwater; Jan N M Commandeur; Wiro M P B Menge; Nico P E Vermeulen
Activation of microsomal glutathione S-transferase and inhibition of cytochrome P450 1A1 activity as a model system for detecting protein alkylation by thiourea-containing compounds in rat liver microsomes.
Chemical research in toxicology 1999;12(5):396-402.
1999: Michel Kranendonk; Filipa Carreira Barbosa; P Theisen; António Laires; Charles W Fisher; Jose Rueff; Ronald W Estabrook; Nico P E Vermeulen
Escherichia coli MTC, a human NADPH P450 reductase competent mutagenicity tester strain for the expression of human cytochrome P450 isoforms 1A1, 1A2, 2A6, 3A4, or 3A5: catalytic activities and mutagenicity studies.
Mutation research 1999;441(1):73-83.
1999: Michel Kranendonk; Charles W Fisher; R Roda; Filipa Carreira Barbosa; P Theisen; António Laires; Jose Rueff; Nico P E Vermeulen; Ronald W Estabrook
Escherichia coli MTC, a NADPH cytochrome P450 reductase competent mutagenicity tester strain for the expression of human cytochrome P450: comparison of three types of expression systems.
Mutation research 1999;439(2):287-300.
1999: LL De Zwart; Nico P E Vermeulen; Ralph Hermanns; Jan N M Commandeur; PJ Salemink; John Meerman
Urinary excretion of biomarkers for radical-induced damage in rats treated with NDMA or diquat and the effects of calcium carbimide co-administration.
Chemico-biological interactions 1999;117(2):151-72.
1999: Lars W Wormhoudt; Jan N M Commandeur; Nico P E Vermeulen
Genetic polymorphisms of human N-acetyltransferase, cytochrome P450, glutathione-S-transferase, and epoxide hydrolase enzymes: relevance to xenobiotic metabolism and toxicity.
Critical reviews in toxicology 1999;29(1):59-124.
1999: LL De Zwart; John Meerman; Jan N M Commandeur; Nico P E Vermeulen
Biomarkers of free radical damage applications in experimental animals and in humans.
Free radical biology & medicine 1999;26(1-2):202-26.
1998: J G Bessems; Marcel J de Groot; E J Baede; Johan teKoppele; Nico P E Vermeulen
Hydrogen atom abstraction of 3,5-disubstituted analogues of paracetamol by horseradish peroxidase and cytochrome P450.
Xenobiotica; the fate of foreign compounds in biological systems 1998;28(9):855-75.
1998: E M van der Aar; K T Tan; Jan N M Commandeur; Nico P E Vermeulen
Strategies to characterize the mechanisms of action and the active sites of glutathione S-transferases: a review.
Drug metabolism reviews 1998;30(3):569-643.
1998: Ralph Hermanns; LL De Zwart; PJ Salemink; Jan N M Commandeur; Nico P E Vermeulen; John Meerman
Urinary excretion of biomarkers of oxidative kidney damage induced by ferric nitrilotriacetate.
Toxicological sciences : an official journal of the Society of Toxicology 1998;43(2):241-9.
1998: Michel Kranendonk; P Mesquita; António Laires; Nico P E Vermeulen; Jose Rueff
Expression of human cytochrome P450 1A2 in Escherichia coli: a system for biotransformation and genotoxicity studies of chemical carcinogens.
Mutagenesis 1998;13(3):263-9.
1998: Lars W Wormhoudt; AM Hissink; Jan N M Commandeur; Peter J van Bladeren; Nico P E Vermeulen
Disposition of 1,2-[14C]Dibromoethane in male Wistar rats.
Drug metabolism and disposition: the biological fate of chemicals 1998;26(5):437-47.
1998: Nico P E Vermeulen; Jan N M Commandeur; Ed J Groot; Lars W Wormhoudt; S Ramnatshing; Q J Li; J P Brakenhoff
Toxicity of fotemustine in rat hepatocytes and mechanism-based protection against it.
Chemico-biological interactions 1998;110(3):139-58.
1998: Marcel J de Groot; Remco W A Havenith; H Maarten Vinkers; R Zwaans; Nico P E Vermeulen; Joop H van Lenthe
Ab initio calculations on iron-porphyrin model systems for intermediates in the oxidative cycle of cytochrome P450s.
Journal of computer-aided molecular design 1998;12(2):183-93.
1998: R C A Onderwater; Jan N M Commandeur; Ed J Groot; A Sitters; Wiro M P B Menge; Nico P E Vermeulen
Cytotoxicity of a series of mono- and di-substituted thiourea in freshly isolated rat hepatocytes: a preliminary structure-toxicity relationship study.
Toxicology 1998;125(2-3):117-29.
1998: B M de Rooij; Jan N M Commandeur; J W Hommes; T Aalbers; Ed J Groot; Nico P E Vermeulen
Urinary metabolite profile of phenyl and o-cresyl glycidyl ether in rats: identification of a novel pathway leading to N-acetylserine O-conjugates.
Chemical research in toxicology 1998;11(2):111-8.
1998: LL De Zwart; Ralph Hermanns; John Meerman; Jan N M Commandeur; PJ Salemink; Nico P E Vermeulen
Evaluation of urinary biomarkers for radical-induced liver damage in rats treated with carbon tetrachloride.
Toxicology and applied pharmacology 1998;148(1):71-82.
1997: Marcel J de Groot; Nico P E Vermeulen
Modeling the active sites of cytochrome P450s and glutathione S-transferases, two of the most important biotransformation enzymes.
Drug metabolism reviews 1997;29(3):747-99.
1997: LL De Zwart; Jennifer Venhorst; M Groot; Jan N M Commandeur; Ralph Hermanns; John Meerman; B L Van Baar; Nico P E Vermeulen
Simultaneous determination of eight lipid peroxidation degradation products in urine of rats treated with carbon tetrachloride using gas chromatography with electron-capture detection.
Journal of chromatography. B, Biomedical sciences and applications 1997;694(2):277-87.
1997: B M de Rooij; Peter J Boogaard; Jan N M Commandeur; Nico P E Vermeulen
3-Chloro-2-hydroxypropylmercapturic acid and α-chlorohydrin as biomarkers of occupational exposure to epichlorohydrin.
Environmental toxicology and pharmacology 1997;3(3):175-85.
1997: Michel Kranendonk; Jan N M Commandeur; António Laires; Jose Rueff; Nico P E Vermeulen
Characterization of enzyme activities and cofactors involved in bioactivation and bioinactivation of chemical carcinogens in the tester strains Escherichia coli K12 MX100 and Salmonella typhimurium LT2 TA100.
Mutagenesis 1997;12(4):245-54.
1997: Marcel J de Groot; GJ Bijloo; FA van Acker; Célia Fonseca Guerra; J G Snijders; Nico P E Vermeulen
Extension of a predictive substrate model for human cytochrome P4502D6.
Xenobiotica; the fate of foreign compounds in biological systems 1997;27(4):357-68.
1997: E M van der Aar; Marcel J de Groot; T Bouwman; GJ Bijloo; Jan N M Commandeur; Nico P E Vermeulen
4-Substituted 1-chloro-2-nitrobenzenes: structure-activity relationships and extension of the substrate model of rat glutathione S-transferase 4-4.
Chemical research in toxicology 1997;10(4):439-49.
1997: Lars W Wormhoudt; Jan N M Commandeur; J H Ploemen; R S Abdoelgafoer; A Makansi; Peter J van Bladeren; Nico P E Vermeulen
Urinary thiodiacetic acid. A selective biomarker for the cytochrome P450-catalyzed oxidation of 1,2-dibromoethane in the rat.
Drug metabolism and disposition: the biological fate of chemicals 1997;25(4):508-15.
1997: J P Ploemen; Lars W Wormhoudt; G R Haenen; MJ Oudshoorn; Jan N M Commandeur; Nico P E Vermeulen; I de Waziers; P H Beaune; T Watabe; Peter J van Bladeren
The use of human in vitro metabolic parameters to explore the risk assessment of hazardous compounds: the case of ethylene dibromide.
Toxicology and applied pharmacology 1997;143(1):56-69.
1997: J G Bessems; Leo van Stee; Jan N M Commandeur; Ed J Groot; Nico P E Vermeulen
Cytotoxicity of paracetamol and 3,5-dihalogenated analogues: Role of cytochrome P-450 and formation of GSH conjugates and protein adducts.
Toxicology in vitro : an international journal published in association with BIBRA 1997;11(1-2):9-19.
1997: Marcel J de Groot; GJ Bijloo; B J Martens; FA van Acker; Nico P E Vermeulen
A refined substrate model for human cytochrome P450 2D6.
Chemical research in toxicology 1997;10(1):41-8.
1996: E M Van der Aar; T Bouwman; Jan N M Commandeur; Nico P E Vermeulen
Structure-activity relationships for chemical and glutathione S-transferase-catalysed glutathione conjugation reactions of a series of 2-substituted 1-chloro-4-nitrobenzenes.
The Biochemical journal 1996;320 ( Pt 2)():531-40.
1996: R C A Onderwater; A R Goeptar; P R Levering; R M Vos; P N Konings; Johannes Doehmer; Jan N M Commandeur; Nico P E Vermeulen
The use of macroporous microcarriers for the large-scale growth of V79 cells genetically designed to express single human cytochrome P450 isoenzymes and for the characterization of the expressed cytochrome P450.
Protein expression and purification 1996;8(4):439-46.
1996: I Andreadou; B van de Water; Jan N M Commandeur; F J Nagelkerke; Nico P E Vermeulen
Comparative cytotoxicity of 14 novel selenocysteine se-conjugates in rat renal proximal tubular cells.
Toxicology and applied pharmacology 1996;141(1):278-87.
1996: B M De Rooij; Jan N M Commandeur; J R Ramcharan; H C Schuilenburg; B L Van Baar; Nico P E Vermeulen
Identification and quantitative determination of 3-chloro-2-hydroxypropylmercapturic acid and alpha-chlorohydrin in urine of rats treated with epichlorohydrin.
Journal of chromatography. B, Biomedical applications 1996;685(2):241-50.
1996: LL De Zwart; Ralph Hermanns; John Meerman; Jan N M Commandeur; Nico P E Vermeulen
Disposition in rat of [2-3H]-trans-4-hydroxy-2,3-nonenal, a product of lipid peroxidation.
Xenobiotica; the fate of foreign compounds in biological systems 1996;26(10):1087-100.
1996: Jan N M Commandeur; L J King; L Koymans; Nico P E Vermeulen
Bioactivation of S-(2,2-dihalo-1,1-difluoroethyl)-L-cysteines and S-(trihalovinyl)-L-cysteines by cysteine S-conjugate beta-lyase: indications for formation of both thionoacylating species and thiiranes as reactive intermediates.
Chemical research in toxicology 1996;9(7):1092-102.
1996: Marcel J de Groot; Nico P E Vermeulen; J D Kramer; FA van Acker; G M Donné-Op den Kelder
A three-dimensional protein model for human cytochrome P450 2D6 based on the crystal structures of P450 101, P450 102, and P450 108.
Chemical research in toxicology 1996;9(7):1079-91.
1996: Lars W Wormhoudt; J H Ploemen; I de Waziers; Jan N M Commandeur; Philippe Beaune; Peter J van Bladeren; Nico P E Vermeulen
Inter-individual variability in the oxidation of 1,2-dibromoethane: use of heterologously expressed human cytochrome P450 and human liver microsomes.
Chemico-biological interactions 1996;101(3):175-92.
1996: J P Ploemen; M L van Iersel; Lars W Wormhoudt; Jan N M Commandeur; Nico P E Vermeulen; Peter J van Bladeren
In vitro inhibition of rat and human glutathione S-transferase isoenzymes by disulfiram and diethyldithiocarbamate.
Biochemical pharmacology 1996;52(2):197-204.
1996: Jan N M Commandeur; Nico P E Vermeulen
Cytotoxicity and cytoprotective activities of natural compounds. The case of curcumin.
Xenobiotica; the fate of foreign compounds in biological systems 1996;26(7):667-80.
1996: B M de Rooij; Jan N M Commandeur; Ed J Groot; Peter J Boogaard; Nico P E Vermeulen
Biotransformation of allyl chloride in the rat. Influence of inducers on the urinary metabolic profile.
Drug metabolism and disposition: the biological fate of chemicals 1996;24(7):765-72.
1996: Michel Kranendonk; F Pintado; P Mesquita; António Laires; Nico P E Vermeulen; Jose Rueff
MX100, a new Escherichia coli tester strain for use in genotoxicity studies.
Mutagenesis 1996;11(4):327-33.
1996: J G Bessems; Johan teKoppele; P A Van Dijk; L L Van Stee; Jan N M Commandeur; Nico P E Vermeulen
Rat liver microsomal cytochrome P450-dependent oxidation of 3,5-disubstituted analogues of paracetamol.
Xenobiotica; the fate of foreign compounds in biological systems 1996;26(6):647-66.
1996: I Andreadou; Wiro M P B Menge; Jan N M Commandeur; E A Worthington; Nico P E Vermeulen
Synthesis of novel Se-substituted selenocysteine derivatives as potential kidney selective prodrugs of biologically active selenol compounds: evaluation of kinetics of beta-elimination reactions in rat renal cytosol.
Journal of medicinal chemistry 1996;39(10):2040-6.
1996: J P Brakenhoff; Jan N M Commandeur; Lars W Wormhoudt; Ed J Groot; Nico P E Vermeulen
Molecular mechanisms of toxic effects of fotemustine in rat hepatocytes and subcellular rat liver fractions.
Carcinogenesis 1996;17(4):715-24.
1996: E M van der Aar; Marcel J de Groot; GJ Bijloo; Henk van der Goot; Nico P E Vermeulen
Structure-activity relationships for the glutathione conjugation of 2-substituted 1-chloro-4-nitrobenzenes by rat glutathione S-transferase 4-4.
Chemical research in toxicology 1996;9(2):527-34.
1996: E M van der Aar; D Buikema; Jan N M Commandeur; Johan teKoppele; Ben van Ommen; Peter J van Bladeren; Nico P E Vermeulen
Enzyme kinetics and substrate selectivities of rat glutathione S-transferase isoenzymes towards a series of new 2-substituted 1-chloro-4-nitrobenzenes.
Xenobiotica; the fate of foreign compounds in biological systems 1996;26(2):143-55.
1996: S Oetari; M Sudibyo; Jan N M Commandeur; R Samhoedi; Nico P E Vermeulen
Effects of curcumin on cytochrome P450 and glutathione S-transferase activities in rat liver.
Biochemical pharmacology 1996;51(1):39-45.
1996: Lars W Wormhoudt; J H Ploemen; Jan N M Commandeur; Ben van Ommen; Peter J van Bladeren; Nico P E Vermeulen
Cytochrome P450 catalyzed metabolism of 1,2-dibromoethane in liver microsomes of differentially induced rats.
Chemico-biological interactions 1996;99(1-3):41-53.
1996: Marcel J de Groot; Nico P E Vermeulen; D L Mullenders; G M Donné-Op den Kelder
A homology model for rat mu class glutathione S-transferase 4-4.
Chemical research in toxicology 1996;9(1):28-40.
1996: B M de Rooij; Peter J Boogaard; D A Rijksen; Jan N M Commandeur; Nico P E Vermeulen
Urinary excretion of N-acetyl-S-allyl-L-cysteine upon garlic consumption by human volunteers.
Archives of toxicology 1996;70(10):635-9.
1995: J G Bessems; H D Gaisser; Johan teKoppele; W P Van Bennekom; Jan N M Commandeur; Nico P E Vermeulen
3,5-Disubstituted analogues of paracetamol. Synthesis, analgesic activity and cytotoxicity.
Chemico-biological interactions 1995;98(3):237-50.
1995: D Remirez; J N Commandeur; Ed J Groot; Nico P E Vermeulen
Mechanism of protection of lobenzarit against paracetamol-induced toxicity in rat hepatocytes.
European journal of pharmacology 1995;293(4):301-8.
1995: A R Goeptar; Johan teKoppele; H R Glatt; Ed J Groot; Albrecht Seidel; M Barrenscheen; C Wölfel; Johannes Doehmer; Nico P E Vermeulen
The cytotoxicity of mitomycin C and adriamycin in genetically engineered V79 cell lines and freshly isolated rat hepatocytes.
Chemico-biological interactions 1995;97(2):149-68.
1995: Marcel J de Groot; E M van der Aar; P J Nieuwenhuizen; R M van der Plas; G M Donné-Op den Kelder; Jan N M Commandeur; Nico P E Vermeulen
A predictive substrate model for rat glutathione S-transferase 4-4.
Chemical research in toxicology 1995;8(5):649-58.
1995: Marcel J de Groot; GJ Bijloo; Kristian Tage Hansen; Nico P E Vermeulen
Computer prediction and experimental validation of cytochrome P4502D6-dependent oxidation of GBR 12909.
Drug metabolism and disposition: the biological fate of chemicals 1995;23(6):667-9.
1995: Jan N M Commandeur; G J Stijntjes; Nico P E Vermeulen
Enzymes and transport systems involved in the formation and disposition of glutathione S-conjugates. Role in bioactivation and detoxication mechanisms of xenobiotics.
Pharmacological reviews 1995;47(2):271-330.
1995: J H Ploemen; Lars W Wormhoudt; Ben van Ommen; Jan N M Commandeur; Nico P E Vermeulen; Peter J van Bladeren
Polymorphism in the glutathione conjugation activity of human erythrocytes towards ethylene dibromide and 1,2-epoxy-3-(p-nitrophenoxy)-propane.
Biochimica et biophysica acta 1995;1243(3):469-76.
1995: Marcel J de Groot; G M Donné-Op den Kelder; Jan N M Commandeur; J H van Lenthe; Nico P E Vermeulen
Metabolite predictions for para-substituted anisoles based on ab initio complete active space self-consistent field calculations.
Chemical research in toxicology 1995;8(3):437-43.
1995: M Maliepaard; Nico J de Mol; LH Janssen; A R Goeptar; Johan teKoppele; Nico P E Vermeulen; W Verboom; D N Reinhoudt
Reduction of antitumour mitosenes in non-aqueous and aqueous environment. An electron spin resonance and cyclic voltammetry study.
Free radical research 1995;22(2):109-21.
1995: A R Goeptar; H Scheerens; Nico P E Vermeulen
Oxygen and xenobiotic reductase activities of cytochrome P450.
Critical reviews in toxicology 1995;25(1):25-65.
1995: A R Goeptar; Jan N M Commandeur; Ben van Ommen; Peter J van Bladeren; Nico P E Vermeulen
Metabolism and kinetics of trichloroethylene in relation to toxicity and carcinogenicity. Relevance of the mercapturic acid pathway.
Chemical research in toxicology 1995;8(1):3-21.
1994: Q J Li; J G Bessems; Jan N M Commandeur; B Adams; Nico P E Vermeulen
Mechanism of protection of ebselen against paracetamol-induced toxicity in rat hepatocytes.
Biochemical pharmacology 1994;48(8):1631-40.
1994: A R Goeptar; Ed J Groot; H Scheerens; Jan N M Commandeur; Nico P E Vermeulen
Cytotoxicity of mitomycin C and adriamycin in freshly isolated rat hepatocytes: the role of cytochrome P450.
Cancer research 1994;54(9):2411-8.
1994: J P Brakenhoff; Jan N M Commandeur; Frans J J de Kanter; B L van Baar; W C Luijten; Nico P E Vermeulen
Chemical and glutathione conjugation-related degradation of fotemustine: formation and characterization of a glutathione conjugate of diethyl (1-isocyanatoethyl)phosphonate, a reactive metabolite of fotemustine.
Chemical research in toxicology 1994;7(3):380-9.
1993: A Yamauchi; G J Stijntjes; Jan N M Commandeur; Nico P E Vermeulen
Purification of glutamine transaminase K/cysteine conjugate beta-lyase from rat renal cytosol based on hydrophobic interaction HPLC and gel permeation FPLC.
Protein expression and purification 1993;4(6):552-62.
1993: A R Goeptar; Johan teKoppele; E K Lamme; J M Piqué; Nico P E Vermeulen
Cytochrome P450 2B1-mediated one-electron reduction of adriamycin: a study with rat liver microsomes and purified enzymes.
Molecular pharmacology 1993;44(6):1267-77.
1993: J P Brakenhoff; Jan N M Commandeur; M H Lamorée; A C Dubelaar; B L van Baar; C Lucas; Nico P E Vermeulen
Identification and quantitative determination of glutathione-related urinary metabolites of fotemustine, a new anti-cancer agent.
Xenobiotica; the fate of foreign compounds in biological systems 1993;23(8):935-47.
1993: L M Koymans; Nico P E Vermeulen; A Baarslag; G M Donné-Op den Kelder
A preliminary 3D model for cytochrome P450 2D6 constructed by homology model building.
Journal of computer-aided molecular design 1993;7(3):281-9.
1993: L Koymans; G M Donné-Op den Kelder; Johan teKoppele; Nico P E Vermeulen
Generalized cytochrome P450-mediated oxidation and oxygenation reactions in aromatic substrates with activated N-H, O-H, C-H, or S-H substituents.
Xenobiotica; the fate of foreign compounds in biological systems 1993;23(6):633-48.
1993: G J Stijntjes; Jan N M Commandeur; Johan teKoppele; S McGuinness; A Gandolfi; Nico P E Vermeulen
Examination of the structure-toxicity relationships of L-cysteine-S-conjugates of halogenated alkenes and their corresponding mercapturic acids in rat renal tissue slices.
Toxicology 1993;79(1):67-79.
1993: L Koymans; G M Donné-op den Kelder; J M Koppele Te; Nico P E Vermeulen
Cytochromes P450: their active-site structure and mechanism of oxidation.
Drug metabolism reviews 1993;25(3):325-87.
1993: Nico P E Vermeulen; G S Baldew; Gerrit Los; J G McVie; J J De Goeij
Reduction of cisplatin nephrotoxicity by sodium selenite. Lack of interaction at the pharmacokinetic level of both compounds.
Drug metabolism and disposition: the biological fate of chemicals 1993;21(1):30-6.
1993: Johannes Doehmer; A R Goeptar; Nico P E Vermeulen
Cytochromes P450 and drug resistance.
Cytotechnology 1993;12(1-3):357-66.
1992: G J Stijntjes; Johan teKoppele; Nico P E Vermeulen
High-performance liquid chromatography-fluorescence assay of pyruvic acid to determine cysteine conjugate beta-lyase activity: application to S-1,2-dichlorovinyl-L-cysteine and S-2-benzothiazolyl-L-cysteine.
Analytical biochemistry 1992;206(2):334-43.
1992: Nico P E Vermeulen; G S Baldew
The role of lipid peroxidation in the nephrotoxicity of cisplatin.
Biochemical pharmacology 1992;44(6):1193-9.
1992: A R Goeptar; Johan teKoppele; E P Neve; Nico P E Vermeulen
Reductase and oxidase activity of rat liver cytochrome P450 with 2,3,5,6-tetramethylbenzoquinone as substrate.
Chemico-biological interactions 1992;83(3):249-69.
1992: G S Baldew; A P Boymans; J G Mol; Nico P E Vermeulen
The influence of ebselen on the toxicity of cisplatin in LLC-PK1 cells.
Biochemical pharmacology 1992;44(2):382-7.
1992: J J Hageman; Aalt Bast; Nico P E Vermeulen
Monitoring of oxidative free radical damage in vivo: analytical aspects.
Chemico-biological interactions 1992;82(3):243-93.
1992: L Koymans; Nico P E Vermeulen; Saskia van Acker; Johan teKoppele; J J Heykants; Karel Lavrijsen; W Meuldermans; G M Donné-Op den Kelder
A predictive model for substrates of cytochrome P450-debrisoquine (2D6).
Chemical research in toxicology 1992;5(2):211-9.
1992: A R Goeptar; Johan teKoppele; J M van Maanen; C E Zoetemelk; Nico P E Vermeulen
One-electron reductive bioactivation of 2,3,5,6-tetramethylbenzoquinone by cytochrome P450.
Biochemical pharmacology 1992;43(2):343-52.
1992: Nico P E Vermeulen; J G Bessems; R Van de Straat
Molecular aspects of paracetamol-induced hepatotoxicity and its mechanism-based prevention.
Drug metabolism reviews 1992;24(3):367-407.
1992: R T van Welie; R G van Dijck; Nico P E Vermeulen; N J van Sittert
Mercapturic acids, protein adducts, and DNA adducts as biomarkers of electrophilic chemicals.
Critical reviews in toxicology 1992;22(5-6):271-306.
1991: R T van Welie; C M van Marrewijk; F A de Wolff; Nico P E Vermeulen
Thioether excretion in urine of applicators exposed to 1,3-dichloropropene: a comparison with urinary mercapturic acid excretion.
British journal of industrial medicine 1991;48(7):492-8.
1991: Jan N M Commandeur; G J Stijntjes; J Wijngaard; Nico P E Vermeulen
Metabolism of L-cysteine S-conjugates and N-(trideuteroacetyl)-L-cysteine S-conjugates of four fluoroethylenes in the rat. Role of balance of deacetylation and acetylation in relation to the nephrotoxicity of mercapturic acids.
Biochemical pharmacology 1991;42(1):31-8.
1991: G S Baldew; J G Mol; Frans J J de Kanter; B van Baar; J J de Goeij; Nico P E Vermeulen
The mechanism of interaction between cisplatin and selenite.
Biochemical pharmacology 1991;41(10):1429-37.
1991: Guido R M M Haenen; Frank Jansen; Nico P E Vermeulen; Aalt Bast
Activation of the microsomal glutathione S-transferase by metabolites of alpha-methyldopa.
Archives of biochemistry and biophysics 1991;287(1):48-52.
1991: M Wilbrink; Ed J Groot; R Jansen; Y De Vries; Nico P E Vermeulen
Occurrence of a cytochrome P-450-containing mixed-function oxidase system in the pond snail, Lymnaea stagnalis.
Xenobiotica; the fate of foreign compounds in biological systems 1991;21(2):223-33.
1991: R M Vos; R T van Welie; W H Peters; C T Evelo; J J Boogaards; Nico P E Vermeulen; Peter J van Bladeren
Genetic deficiency of human class mu glutathione S-transferase isoenzymes in relation to the urinary excretion of the mercapturic acids of Z- and E-1,3-dichloropropene.
Archives of toxicology 1991;65(2):95-9.
1991: R T van Welie; P van Duyn; Derk H Brouwer; Joop J Van Hemmen; Elisabeth Brouwer; Nico P E Vermeulen
Inhalation exposure to 1,3-dichloropropene in the Dutch flower-bulb culture. Part II. Biological monitoring by measurement of urinary excretion of two mercapturic acid metabolites.
Archives of environmental contamination and toxicology 1991;20(1):6-12.
1991: Jan N M Commandeur; Peter J Boogaard; G J Mulder; Nico P E Vermeulen
Mutagenicity and cytotoxicity of two regioisomeric mercapturic acids and cysteine S-conjugates of trichloroethylene.
Archives of toxicology 1991;65(5):373-80.
1991: R T van Welie; P van Duyn; E K Lamme; P Jäger; B L van Baar; Nico P E Vermeulen
Determination of tetrahydrophtalimide and 2-thiothiazolidine-4-carboxylic acid, urinary metabolites of the fungicide captan, in rats and humans.
International archives of occupational and environmental health 1991;63(3):181-6.
1991: R T van Welie; P van Duyn; Nico P E Vermeulen
Environmental and biological monitoring of non-occupational exposure to 1,3-dichloropropene.
International archives of occupational and environmental health 1991;63(3):169-73.
1991: R T van Welie; R Mensert; P Van Duyn; Nico P E Vermeulen
Identification and quantitative determination of a carboxylic and a mercapturic acid metabolite of etridiazole in urine of rat and man. Potential tools for biological monitoring.
Archives of toxicology 1991;65(8):625-32.
1990: G S Baldew; J G McVie; M A van der Valk; Gerrit Los; J J de Goeij; Nico P E Vermeulen
Selective reduction of cis-diamminedichloroplatinum(II) nephrotoxicity by ebselen.
Cancer research 1990;50(21):7031-6.
1990: R M Vromans; R van de Straat; M Groeneveld; Nico P E Vermeulen
One-electron reduction of mitomycin c by rat liver: role of cytochrome P-450 and NADPH-cytochrome P-450 reductase.
Xenobiotica; the fate of foreign compounds in biological systems 1990;20(9):967-78.
1990: M Wilbrink; M Treskes; T A De Vlieger; Nico P E Vermeulen
Comparative toxicokinetics of 2,2'- and 4,4'-dichlorobiphenyls in the pond snail Lymnaea stagnalis (L.).
Archives of environmental contamination and toxicology 1990;19(4):565-71.
1990: I A Donatus; Nico P E Vermeulen
Cytotoxic and cytoprotective activities of curcumin. Effects on paracetamol-induced cytotoxicity, lipid peroxidation and glutathione depletion in rat hepatocytes.
Biochemical pharmacology 1990;39(12):1869-75.
1990: Jan N M Commandeur; Nico P E Vermeulen
Molecular and biochemical mechanisms of chemically induced nephrotoxicity: a review.
Chemical research in toxicology 1990;3(3):171-94.
1990: Jan N M Commandeur; Nico P E Vermeulen
Identification of N-acetyl(2,2-dichlorovinyl)- and N-acetyl(1,2-dichlorovinyl)-L-cysteine as two regioisomeric mercapturic acids of trichloroethylene in the rat.
Chemical research in toxicology 1990;3(3):212-8.
1990: L Koymans; J H Van Lenthe; G M Donné-op Den Kelder; Nico P E Vermeulen
Mechanisms of activation of phenacetin to reactive metabolites by cytochrome P-450: a theoretical study involving radical intermediates.
Molecular pharmacology 1990;37(3):452-60.
1990: Guido R M M Haenen; B M De Rooij; Nico P E Vermeulen; Aalt Bast
Mechanism of the reaction of ebselen with endogenous thiols: dihydrolipoate is a better cofactor than glutathione in the peroxidase activity of ebselen.
Molecular pharmacology 1990;37(3):412-22.
1989: R T van Welie; P van Duyn; Nico P E Vermeulen
Determination of two mercapturic acid metabolites of 1,3-dichloropropene in human urine with gas chromatography and sulphur-selective detection.
Journal of chromatography 1989;496(2):463-71.
1989: Peter J Boogaard; Jan N M Commandeur; Gerard J Mulder; Nico P E Vermeulen; J Fred Nagelkerke
Toxicity of the cysteine-S-conjugates and mercapturic acids of four structurally related difluoroethylenes in isolated proximal tubular cells from rat kidney. Uptake of the conjugates and activation to toxic metabolites.
Biochemical pharmacology 1989;38(21):3731-41.
1989: Jan N M Commandeur; Frans J J de Kanter; Nico P E Vermeulen
Bioactivation of the cysteine-S-conjugate and mercapturic acid of tetrafluoroethylene to acylating reactive intermediates in the rat: dependence of activation and deactivation activities on acetyl coenzyme A availability.
Molecular pharmacology 1989;36(4):654-63.
1989: G S Baldew; K J Volkers; J J De Goeij; Nico P E Vermeulen
Determination of cisplatin and related platinum complexes in plasma ultrafiltrate and urine by high-performance liquid chromatography with on-line radioactivity detection.
Journal of chromatography 1989;491(1):163-74.
1989: G S Baldew; C J van den Hamer; Gerrit Los; Nico P E Vermeulen; J J de Goeij; J G McVie
Selenium-induced protection against cis-diamminedichloroplatinum(II) nephrotoxicity in mice and rats.
Cancer research 1989;49(11):3020-3.
1989: Nico P E Vermeulen; J de Jong; E J van Bergen; R T van Welie
N-acetyl-S-(2-hydroxyethyl)-L-cysteine as a potential tool in biological monitoring studies? A critical evaluation of possibilities and limitations.
Archives of toxicology 1989;63(3):173-84.
1989: Guido R M M Haenen; Nico P E Vermeulen; H Timmerman; Aalt Bast
Effect of thiols on lipid peroxidation in rat liver microsomes.
Chemico-biological interactions 1989;71(2-3):201-12.
1989: Guido R M M Haenen; H J Plug; Nico P E Vermeulen; H Timmerman; Aalt Bast
Contribution of 4-hydroxy-2,3-trans-nonenal to the reduction of beta-adrenoceptor function in the heart by oxidative stress.
Life sciences 1989;45(1):71-6.
1989: L Koymans; J H van Lenthe; R van de Straat; G M Donné-Op den Kelder; Nico P E Vermeulen
A theoretical study on the metabolic activation of paracetamol by cytochrome P-450: indications for a uniform oxidation mechanism.
Chemical research in toxicology 1989;2(1):60-6.
1988: Jan N M Commandeur; J P Brakenhoff; Frans J J de Kanter; Nico P E Vermeulen
Nephrotoxicity of mercapturic acids of three structurally related 2,2-difluoroethylenes in the rat. Indications for different bioactivation mechanisms.
Biochemical pharmacology 1988;37(23):4495-504.
1988: R van de Straat; GJ Bijloo; Nico P E Vermeulen
Paracetamol, 3-monoalkyl- and 3,5-dialkyl-substituted derivatives. Antioxidant activity and relationship between lipid peroxidation and cytotoxicity.
Biochemical pharmacology 1988;37(18):3473-6.
1988: Guido R M M Haenen; Nico P E Vermeulen; J N Tai Tin Tsoi; H M Ragetli; H Timmerman; A Blast
Activation of the microsomal glutathione-S-transferase and reduction of the glutathione dependent protection against lipid peroxidation by acrolein.
Biochemical pharmacology 1988;37(10):1933-8.
1988: R van de Straat; R M Vromans; P Bosman; J de Vries; Nico P E Vermeulen
Cytochrome P-450-mediated oxidation of substrates by electron-transfer; role of oxygen radicals and of 1- and 2-electron oxidation of paracetamol.
Chemico-biological interactions 1988;64(3):267-80.
1988: Guido R M M Haenen; P Van Dansik; Nico P E Vermeulen; H Timmerman; Aalt Bast
The effect of hydrogen peroxide on beta-adrenoceptor function in the heart.
Free radical research communications 1988;4(4):243-9.
1987: Jan N M Commandeur; Robert Oostendorp; P R Schoofs; B Xu; Nico P E Vermeulen
Nephrotoxicity and hepatotoxicity of 1,1-dichloro-2,2-difluoroethylene in the rat. Indications for differential mechanisms of bioactivation.
Biochemical pharmacology 1987;36(24):4229-37.
1987: Guido R M M Haenen; J N Tai Tin Tsoi; Nico P E Vermeulen; H Timmerman; Aalt Bast
4-Hydroxy-2,3-trans-nonenal stimulates microsomal lipid peroxidation by reducing the glutathione-dependent protection.
Archives of biochemistry and biophysics 1987;259(2):449-56.
1987: R van de Straat; J de Vries; H J de Boer; R M Vromans; Nico P E Vermeulen
Relationship between paracetamol binding to and its oxidation by two cytochromes P-450 isozymes--a proton nuclear magnetic resonance and spectrophotometric study.
Xenobiotica; the fate of foreign compounds in biological systems 1987;17(1):1-9.
1981: Peter J van Bladeren; Douwe D Breimer; J A van Huijgevoort; Nico P E Vermeulen; Arne van der Gen
The metabolic formation of N-acetyl-S-2-hydroxyethyl-L-cysteine from tetradeutero-1,2-dibromoethane. relative importance of oxidation and glutathione conjugation in vivo.
Biochemical pharmacology 1981;30(17):2499-502.