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David Bowtell

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Lars O Baumbusch; Kathryn Alsop; David D L Bowtell; Pat Brown; Anna deFazio; Dariush Etemadmoghadam; Sian Fereday; Ruth Holm; Gunnar Kristensen; Knut Liestøl; Ole Christian Lingjaerde; Gillian Mitchell; Marci E Schaner; Yun Wang; Aslaug Helland; Anne-Lise Børresen-Dale
High levels of genomic aberrations in serous ovarian cancers are associated with better survival.
Zhigang C Wang; alexander miron; Gillian Mitchell; Huiying Piao; John Quackenbush; Helga B Salvesen; Matthew Schwede; Ruiyang Tian; Kathryn Alsop; Ross S Berkowitz; Nicolai Juul Birkbak; David D L Bowtell; Aedín C Culhane; Kathryn E Daniels; Anna deFazio; Ronny Drapkin; Dariush Etemadmoghadam; Aquila Fatima; J Dirk Iglehart; Joyce Liu; Ursula Matulonis
Profiles of genomic instability in high-grade serous ovarian cancer predict treatment outcome.
Prue A Cowin; Carleen Cullinane; Anna deFazio; Dariush Etemadmoghadam; Sian Fereday; Michael Friedlander; Sarah Ftouni; Laura Galletta; Joshy George; Paul R Harnett; Viola Heinzelmann-Schwarz; Joy Hendley; Elizabeth Loehrer; Orla McNally; Richard B Pearson; Michael Quinn; Karen E Sheppard; Peter Van Loo; Michael S Anglesio; Leanne Bowes; David D L Bowtell; Peter Campbell; Elizabeth L Christie
LRP1B deletion in high-grade serous ovarian cancers is associated with acquired chemotherapy resistance to liposomal doxorubicin.

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All Publications

2013: Lars O Baumbusch; Kathryn Alsop; David D L Bowtell; Pat Brown; Anna deFazio; Dariush Etemadmoghadam; Sian Fereday; Ruth Holm; Gunnar Kristensen; Knut Liestøl; Ole Christian Lingjaerde; Gillian Mitchell; Marci E Schaner; Yun Wang; Aslaug Helland; Anne-Lise Børresen-Dale
High levels of genomic aberrations in serous ovarian cancers are associated with better survival.
PloS one 2013;8(1):e54356.
2012: Zhigang C Wang; alexander miron; Gillian Mitchell; Huiying Piao; John Quackenbush; Helga B Salvesen; Matthew Schwede; Ruiyang Tian; Kathryn Alsop; Ross S Berkowitz; Nicolai Juul Birkbak; David D L Bowtell; Aedín C Culhane; Kathryn E Daniels; Anna deFazio; Ronny Drapkin; Dariush Etemadmoghadam; Aquila Fatima; J Dirk Iglehart; Joyce Liu; Ursula Matulonis
Profiles of genomic instability in high-grade serous ovarian cancer predict treatment outcome.
Clinical cancer research : an official journal of the American Association for Cancer Research 2012;18(20):5806-15.
2012: Prue A Cowin; Carleen Cullinane; Anna deFazio; Dariush Etemadmoghadam; Sian Fereday; Michael Friedlander; Sarah Ftouni; Laura Galletta; Joshy George; Paul R Harnett; Viola Heinzelmann-Schwarz; Joy Hendley; Elizabeth Loehrer; Orla McNally; Richard B Pearson; Michael Quinn; Karen E Sheppard; Peter Van Loo; Michael S Anglesio; Leanne Bowes; David D L Bowtell; Peter Campbell; Elizabeth L Christie
LRP1B deletion in high-grade serous ovarian cancers is associated with acquired chemotherapy resistance to liposomal doxorubicin.
Cancer research 2012;72(16):4060-73.
2012: David J McBride; Charlotte K Ng; Keiran Raine; Michael R Stratton; Jon Teague; David C Wedge; Kathryn Alsop; James D Brenton; Adam Butler; Peter J Campbell; Australian Ovarian Cancer Study Group; Xavier Caubit; Juok Cho; Susanna L Cooke; Dariush Etemadmoghadam; P Andrew Futreal; Danushka Galappaththige; Joshy George; Chris Greenman; Karen D Howarth; King W Lau; David D L Bowtell
Tandem duplication of chromosomal segments is common in ovarian and breast cancer genomes.
The Journal of pathology 2012;227(4):446-55.
2011: Yoshito Nagano; Kazuo Okemoto; John C Reed; Ze'ev Ronai; Keiichiro Tanaka; David D L Bowtell; Toru Fukushima; Shu-ichi Matsuzawa
Siah1/SIP regulates p27(kip1) stability and cell migration under metabolic stress.
Cell cycle (Georgetown, Tex.) 2011;10(15):2592-602.
2011: Jonathan A Ledermann; Christian Marth; Mark S Carey; Michael Birrer; David D L Bowtell; Stan Kaye; Iain McNeish; Amit Oza; Giovanni Scambia; Gordon Rustin; Frederick B Stehman; David Gershenson; Gillian Thomas; Els Berns; Antonio Casado; Nelleke Ottevanger; Felix Hilpert; Byoung-Gie Kim; Aikou Okamoto; Monica Bacon; Henry Kitchener; Gavin C E Stuart
Role of molecular agents and targeted therapy in clinical trials for women with ovarian cancer.
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 2011;21(4):763-70.
2011: Michael S Anglesio; Joshy George; Hagen Kulbe; Michael Friedlander; Danny Rischin; Charlotte Lemech; Jeremy Power; Jermaine Coward; Prue A Cowin; Colin M House; Probir Chakravarty; Kylie L Gorringe; Ian G Campbell; Aikou Okamoto; Michael J Birrer; David G Huntsman; Anna de Fazio; Steve Kalloger; Frances Balkwill; C Blake Gilks; David D L Bowtell
IL6-STAT3-HIF signaling and therapeutic response to the angiogenesis inhibitor sunitinib in ovarian clear cell cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2011;17(8):2538-48.
2011: Åslaug Helland; Michael S Anglesio; Joshy George; Prue A Cowin; Cameron N Johnstone; Colin M House; Karen E Sheppard; Dariush Etemadmoghadam; Nataliya Melnyk; Anil K Rustgi; Wayne A Phillips; Hilde Johnsen; Ruth Holm; Gunnar Kristensen; Michael J Birrer; Richard B Pearson; Anne-Lise Børresen-Dale; David G Huntsman; Anna deFazio; Chad J Creighton; Gordon K Smyth; David D L Bowtell
Deregulation of MYCN, LIN28B and LET7 in a molecular subtype of aggressive high-grade serous ovarian cancers.
PloS one 2011;6(4):e18064.
2011: Catherine Emmanuel; Natalie Gava; Catherine Kennedy; Rosemary L Balleine; Raghwa Sharma; Gerard Wain; Alison Brand; Russell Hogg; Dariush Etemadmoghadam; Joshy George; Michael J Birrer; Christine L Clarke; Georgia Chenevix-Trench; David D L Bowtell; Paul R Harnett; Anna deFazio
Comparison of expression profiles in ovarian epithelium in vivo and ovarian cancer identifies novel candidate genes involved in disease pathogenesis.
PloS one 2011;6(3):e17617.
2010: David D L Bowtell
The genesis and evolution of high-grade serous ovarian cancer.
Nature reviews. Cancer 2010;10(11):803-8.
2010: Prue A Cowin; Michael Anglesio; Dariush Etemadmoghadam; David D L Bowtell
Profiling the cancer genome.
Annual review of genomics and human genetics 2010;11():133-59.
2010: Ahmed Ashour Ahmed; Zhen Lu; Nicholas B Jennings; Dariush Etemadmoghadam; Luisa Capalbo; Rodrigo O Jacamo; Nuno Barbosa-Morais; Xiao-Feng Le; Pablo Vivas-Mejia; Gabriel Lopez-Berestein; Geoffrey Grandjean; Geoffrey Bartholomeusz; Warren Liao; Michael Andreeff; David D L Bowtell; David M Glover; Anil K Sood; Robert C Bast
SIK2 is a centrosome kinase required for bipolar mitotic spindle formation that provides a potential target for therapy in ovarian cancer.
Cancer cell 2010;18(2):109-21.
2010: Ahmed Ashour Ahmed; Dariush Etemadmoghadam; Jillian Temple; Andy G Lynch; Mohamed Riad; Raghwa Sharma; Colin Stewart; Sian Fereday; Carlos Caldas; Anna Defazio; David D L Bowtell; James D Brenton
Driver mutations in TP53 are ubiquitous in high grade serous carcinoma of the ovary.
The Journal of pathology 2010;221(1):49-56.
2010: Dariush Etemadmoghadam; Joshy George; Prue A Cowin; Carleen Cullinane; Maya Kansara; Kylie L Gorringe; Gordon K Smyth; David D L Bowtell
Amplicon-dependent CCNE1 expression is critical for clonogenic survival after cisplatin treatment and is correlated with 20q11 gain in ovarian cancer.
PloS one 2010;5(11):e15498.
2010: Kylie L Gorringe; Joshy George; Michael S Anglesio; Manasa Ramakrishna; Dariush Etemadmoghadam; Prue Cowin; Anita Sridhar; Louise H Williams; Samantha E Boyle; Nozomu Yanaihara; Aikou Okamoto; Mitsuyoshi Urashima; Gordon K Smyth; Ian G Campbell; David D L Bowtell
Copy number analysis identifies novel interactions between genomic loci in ovarian cancer.
PloS one 2010;5(9):.
2009: Colin M House; Andreas Möller; David D L Bowtell
Siah proteins: novel drug targets in the Ras and hypoxia pathways.
Cancer research 2009;69(23):8835-8.
2009: Chia-Huey Ooi; Tatiana Ivanova; Jeanie Wu; Minghui Lee; Iain Beehuat Tan; Jiong Tao; Lindsay Ward; Jun Hao Koo; Veena Gopalakrishnan; Yansong Zhu; Lai Ling Cheng; Julian Lee; Sun Young Rha; Hyun Cheol Chung; Kumaresan Ganesan; Jimmy So; Khee Chee Soo; Dennis Lim; Weng-Hoong Chan; Wai-Keong Wong; David D L Bowtell; Khay Guan Yeoh; Heike Grabsch; Alex Boussioutas; Patrick Tan
Oncogenic pathway combinations predict clinical prognosis in gastric cancer.
PLoS genetics 2009;5(10):e1000676.
2009: Christina Gewinner; Zhigang C Wang; Andrea Richardson; Julie T Feldstein; Dariush Etemadmoghadam; David D L Bowtell; Jordi Barretina; William M Lin; Lucia Rameh; Leonardo Salmena; Pier Paolo Pandolfi; Lewis C Cantley
Evidence that inositol polyphosphate 4-phosphatase type II is a tumor suppressor that inhibits PI3K signaling.
Cancer cell 2009;16(2):115-25.
2009: A Möller; C M House; C S F Wong; D B Scanlon; M C P Liu; Z Ronai; David D L Bowtell
Inhibition of Siah ubiquitin ligase function.
Oncogene 2009;28(2):289-96.
2009: Marco A Calzado; Laureano de la Vega; Andreas Möller; David D L Bowtell; M Lienhard Schmitz
An inducible autoregulatory loop between HIPK2 and Siah2 at the apex of the hypoxic response.
Nature cell biology 2009;11(1):85-91.
2008: Michael S Anglesio; Jeremy M Arnold; joshy george; Anna V Tinker; Richard Tothill; Nic Waddell; Lisa Simms; Bianca Locandro; Sian Fereday; Nadia Traficante; Peter Russell; Raghwa Sharma; Michael J Birrer; Anna deFazio; Georgia Chenevix-Trench; David D L Bowtell
Mutation of ERBB2 provides a novel alternative mechanism for the ubiquitous activation of RAS-MAPK in ovarian serous low malignant potential tumors.
Molecular cancer research : MCR 2008;6(11):1678-90.
2008: Richard W Tothill; Anna V Tinker; joshy george; Robert Brown; Stephen B Fox; Stephen Lade; Daryl S Johnson; Melanie Trivett; Dariush Etemadmoghadam; Bianca Locandro; Nadia Traficante; Sian Fereday; Jillian A Hung; Yoke-Eng Chiew; Izhak Haviv; Dorota Gertig; Anna DeFazio; David D L Bowtell
Novel molecular subtypes of serous and endometrioid ovarian cancer linked to clinical outcome.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(16):5198-208.
2008: Sunggoo Yun; Andreas Möller; Suhn-Kee Chae; Won-Pyo Hong; Young Ju Bae; David D L Bowtell; Sung Ho Ryu; Pann-Ghill Suh
Siah proteins induce the epidermal growth factor-dependent degradation of phospholipase Cepsilon.
The Journal of biological chemistry 2008;283(2):1034-42.
2006: Michael J Millward; C House; David D L Bowtell; L Webster; Ian N Olver; M Gore; M Copeman; K Lynch; A Yap; Y Wang; P S Cohen; John Zalcberg
The multikinase inhibitor midostaurin (PKC412A) lacks activity in metastatic melanoma: a phase IIA clinical and biologic study.
British journal of cancer 2006;95(7):829-34.
2006: Andrew J Holloway; Dileepa Diyagama; Ken Opeskin; Jenette Creaney; Bruce W S Robinson; Richard A Lake; David D L Bowtell
A molecular diagnostic test for distinguishing lung adenocarcinoma from malignant mesothelioma using cells collected from pleural effusions.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(17):5129-35.
2006: Anna V Tinker; Alex Boussioutas; David D L Bowtell
The challenges of gene expression microarrays for the study of human cancer.
Cancer cell 2006;9(5):333-9.
2006: Colin M House; Nancy C Hancock; Andreas Möller; Brett A Cromer; Victor Fedorov; David D L Bowtell; Michael W Parker; Galina Polekhina
Elucidation of the substrate binding site of Siah ubiquitin ligase.
Structure (London, England : 1993) 2006;14(4):695-701.
2006: Andrew J Holloway; Alicia Oshlack; Dileepa Diyagama; David D L Bowtell; Gordon K Smyth
Statistical analysis of an RNA titration series evaluates microarray precision and sensitivity on a whole-array basis.
BMC bioinformatics 2006;7():511.
2006: Amit Aggarwal; Dong Li Guo; Yujin Hoshida; Siu Tsan Yuen; Kent-Man Chu; Samuel So; Alex Boussioutas; Xin Chen; David D L Bowtell; Hiroyuki Aburatani; Suet Yi Leung; Patrick Tan
Topological and functional discovery in a gene coexpression meta-network of gastric cancer.
Cancer research 2006;66(1):232-41.
2005: T Liu; A Bohlken; Selena Kuljaca; Michelle Lee; Tue Nguyen; S Smith; Belamy Cheung; Murray D Norris; Michelle Haber; Andrew J Holloway; David D L Bowtell; Glenn M Marshall
The retinoid anticancer signal: mechanisms of target gene regulation.
British journal of cancer 2005;93(3):310-8.
2005: Richard W Tothill; Adam Kowalczyk; Danny Rischin; Alex Bousioutas; Izhak Haviv; Ryan Van Laar; Paul Waring; John Zalcberg; Robyn Ward; Andrew V Biankin; Robert L Sutherland; Susan M Henshall; Kwun Fong; Jonathan R Pollack; David D L Bowtell; Andrew J Holloway
An expression-based site of origin diagnostic method designed for clinical application to cancer of unknown origin.
Cancer research 2005;65(10):4031-40.
2005: Melissa J Peart; Gordon K Smyth; Ryan Van Laar; David D L Bowtell; Victoria M Richon; Paul A Marks; Andrew J Holloway; Ricky Johnstone
Identification and functional significance of genes regulated by structurally different histone deacetylase inhibitors.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(10):3697-702.
2005: Kylie L Gorringe; Alex Boussioutas; David D L Bowtell
Novel regions of chromosomal amplification at 6p21, 5p13, and 12q14 in gastric cancer identified by array comparative genomic hybridization.
Genes, chromosomes & cancer 2005;42(3):247-59.
2004: Hasem Habelhah; Aaron Laine; Hediye Erdjument-Bromage; Paul Tempst; M Eric Gershwin; David D L Bowtell; Ze'ev Ronai
Regulation of 2-oxoglutarate (alpha-ketoglutarate) dehydrogenase stability by the RING finger ubiquitin ligase Siah.
The Journal of biological chemistry 2004;279(51):53782-8.
2004: David M Thomas; Sandra A Johnson; Natalie Sims; Melanie Trivett; John L Slavin; Brian P Rubin; Paul Waring; Grant A McArthur; Carl R Walkley; Andrew J Holloway; Dileepa Diyagama; Jonathan E Grim; Bruce E Clurman; David D L Bowtell; Jong-Seo Lee; Gabriel M Gutierrez; Denise M Piscopo; Shannon A Carty; Philip W Hinds
Terminal osteoblast differentiation, mediated by runx2 and p27KIP1, is disrupted in osteosarcoma.
The Journal of cell biology 2004;167(5):925-34.
2004: Juan Carlos Molero; Thomas E Jensen; Phil C Withers; Michelle Couzens; Herbert Herzog; Christine B F Thien; Wallace Y Langdon; Ken Walder; Maria A Murphy; David D L Bowtell; David E James; Gregory J Cooney
c-Cbl-deficient mice have reduced adiposity, higher energy expenditure, and improved peripheral insulin action.
The Journal of clinical investigation 2004;114(9):1326-33.
2004: David M Thomas; N I Fleming; Andrew J Holloway; David D L Bowtell
Molecular medicine: a clinician's primer on microarrays.
Internal medicine journal 2004;34(9-10):565-9.
2004: Ian J Frew; Natalie Sims; Julian M W Quinn; Carl R Walkley; Louise E Purton; David D L Bowtell; Matthew T Gillespie
Osteopenia in Siah1a mutant mice.
The Journal of biological chemistry 2004;279(28):29583-8.
2004: Koh Nakayama; Ian J Frew; Mette Hagensen; Marianne Skals; Hasem Habelhah; Anindita Bhoumik; Takayuki Kadoya; Hediye Erdjument-Bromage; Paul Tempst; Peter Frappell; David D L Bowtell; Ze'ev Ronai
Siah2 regulates stability of prolyl-hydroxylases, controls HIF1alpha abundance, and modulates physiological responses to hypoxia.
Cell 2004;117(7):941-52.
2004: Leonie M Quinn; Ross A Dickins; Michelle Coombe; Gary R Hime; David D L Bowtell; Helena Richardson
Drosophila Hfp negatively regulates dmyc and stg to inhibit cell proliferation.
Development (Cambridge, England) 2004;131(6):1411-23.
2003: Ian J Frew; Vicki E Hammond; Ross A Dickins; Julian M W Quinn; Carl R Walkley; Natalie Sims; Ralf Schnall; Neil G Della; Andrew J Holloway; Matthew R Digby; Peter W Janes; David M Tarlinton; Louise E Purton; Matthew T Gillespie; David D L Bowtell
Generation and analysis of Siah2 mutant mice.
Molecular and cellular biology 2003;23(24):9150-61.
2003: Lei Duan; Yuko Miura; Manjari Dimri; Biswanath Majumder; Ingrid L Dodge; Alagarsamy Lakku Reddi; Amiya Ghosh; Norvin Fernandes; Pengcheng Zhou; Karen Mullane-Robinson; Navin Rao; Stephen Donoghue; Rick A Rogers; David D L Bowtell; Mayumi Naramura; Hua Gu; Vimla Band; Hamid Band
Cbl-mediated ubiquitinylation is required for lysosomal sorting of epidermal growth factor receptor but is dispensable for endocytosis.
The Journal of biological chemistry 2003;278(31):28950-60.
2003: Alex Boussioutas; Hong Li; Jia Liu; Paul Waring; Stephen Lade; Andrew J Holloway; Douglas Taupin; Kylie L Gorringe; Izhak Haviv; Paul V Desmond; David D L Bowtell
Distinctive patterns of gene expression in premalignant gastric mucosa and gastric cancer.
Cancer research 2003;63(10):2569-77.
2003: Elena Caveggion; Silvia Continolo; Fiona J Pixley; E Richard Stanley; David D L Bowtell; Clifford A Lowell; Giorgio Berton
Expression and tyrosine phosphorylation of Cbl regulates macrophage chemokinetic and chemotactic movement.
Journal of cellular physiology 2003;195(2):276-89.
2003: Colin M House; Ian J Frew; Huei-Luen Huang; Gerhard Wiche; Nadia Traficante; Edouard C Nice; Bruno Catimel; David D L Bowtell
A binding motif for Siah ubiquitin ligase.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(6):3101-6.
2003: Christine B F Thien; Robin M Scaife; John M Papadimitriou; Maria A Murphy; David D L Bowtell; Wallace Y Langdon
A mouse with a loss-of-function mutation in the c-Cbl TKB domain shows perturbed thymocyte signaling without enhancing the activity of the ZAP-70 tyrosine kinase.
The Journal of experimental medicine 2003;197(4):503-13.
2002: Andrew J Holloway; Ryan Van Laar; Richard W Tothill; David D L Bowtell
Options available--from start to finish--for obtaining data from DNA microarrays II.
Nature genetics 2002;32 Suppl():481-9.
2002: Ian J Frew; Ross A Dickins; Andrew R Cuddihy; Merci Del Rosario; Christoph Reinhard; Matthew O'Connell; David D L Bowtell
Normal p53 function in primary cells deficient for Siah genes.
Molecular and cellular biology 2002;22(23):8155-64.
2002: Hasem Habelhah; Ian J Frew; Aaron Laine; Peter W Janes; Frédéric Relaix; David Sassoon; David D L Bowtell; Ze'ev Ronai
Stress-induced decrease in TRAF2 stability is mediated by Siah2.
The EMBO journal 2002;21(21):5756-65.
2002: Ross A Dickins; Ian J Frew; Colin M House; Moira K O'Bryan; Andrew J Holloway; Izhak Haviv; Nadia Traficante; David M de Kretser; David D L Bowtell
The ubiquitin ligase component Siah1a is required for completion of meiosis I in male mice.
Molecular and cellular biology 2002;22(7):2294-303.
2002: Galina Polekhina; Colin M House; Nadia Traficante; Joel Mackay; Frédéric Relaix; David Sassoon; Michael W Parker; David D L Bowtell
Siah ubiquitin ligase is structurally related to TRAF and modulates TNF-alpha signaling.
Nature structural biology 2002;9(1):68-75.
2001: W A Blesofsky; K Mowen; Robert M Arduini; Darren P Baker; Maria A Murphy; David D L Bowtell; Michael David
Regulation of STAT protein synthesis by c-Cbl.
Oncogene 2001;20(50):7326-33.
2000: H Robertson; Gary R Hime; H Lada; David D L Bowtell
A Drosophila analogue of v-Cbl is a dominant-negative oncoprotein in vivo.
Oncogene 2000;19(29):3299-308.
2000: Frédéric Relaix; X j Wei; W Li; J Pan; Y Lin; David D L Bowtell; David Sassoon; X Wu
Pw1/Peg3 is a potential cell death mediator and cooperates with Siah1a in p53-mediated apoptosis.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(5):2105-10.
2000: Christopher Andoniou; Nancy L. Lill; Christine B F Thien; ML Lupher; S Ota; David D L Bowtell; Robin M Scaife; Wallace Y Langdon; Hamid Band
The Cbl proto-oncogene product negatively regulates the Src-family tyrosine kinase Fyn by enhancing its degradation.
Molecular and cellular biology 2000;20(3):851-67.
1999: PS Lee; Yarong Wang; Melissa G Dominguez; Yee-Guide Yeung; Maria A Murphy; David D L Bowtell; E Richard Stanley
The Cbl protooncoprotein stimulates CSF-1 receptor multiubiquitination and endocytosis, and attenuates macrophage proliferation.
The EMBO journal 1999;18(13):3616-28.
1999: Christine B F Thien; David D L Bowtell; Wallace Y Langdon
Perturbed regulation of ZAP-70 and sustained tyrosine phosphorylation of LAT and SLP-76 in c-Cbl-deficient thymocytes.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(12):7133-9.
1999: David D L Bowtell
Options available--from start to finish--for obtaining expression data by microarray.
Nature genetics 1999;21(1 Suppl):25-32.
1998: Maria A Murphy; R G Schnall; Deon J Venter; L Barnett; Ivan Bertoncello; Christine B F Thien; Wallace Y Langdon; David D L Bowtell
Tissue hyperplasia and enhanced T-cell signalling via ZAP-70 in c-Cbl-deficient mice.
Molecular and cellular biology 1998;18(8):4872-82.
1997: H Robertson; Wallace Y Langdon; Christine B F Thien; David D L Bowtell
A c-Cbl yeast two hybrid screen reveals interactions with 14-3-3 isoforms and cytoskeletal components.
Biochemical and biophysical research communications 1997;240(1):46-50.
1997: Gary R Hime; M P Dhungat; Ashley Ng; David D L Bowtell
D-Cbl, the Drosophila homologue of the c-Cbl proto-oncogene, interacts with the Drosophila EGF receptor in vivo, despite lacking C-terminal adaptor binding sites.
Oncogene 1997;14(22):2709-19.
1997: Andrew J Holloway; N G Della; C F Fletcher; D A Largespada; N G Copeland; N A Jenkins; David D L Bowtell
Chromosomal mapping of five highly conserved murine homologues of the Drosophila RING finger gene seven-in-absentia.
Genomics 1997;41(2):160-8.
1997: D Z Wang; V E Hammond; Helen E Abud; Ivan Bertoncello; J W McAvoy; David D L Bowtell
Mutation in Sos1 dominantly enhances a weak allele of the EGFR, demonstrating a requirement for Sos1 in EGFR signaling and development.
Genes & development 1997;11(3):309-20.
1997: H G Mack; Felix Beck; David D L Bowtell
A search for a mammalian homologue of the Drosophila photoreceptor development gene glass yields Zfp64, a zinc finger encoding gene which maps to the distal end of mouse chromosome 2.
Gene 1997;185(1):11-7.
1995: N G Della; Y Hu; A J Holloway; D Wang; David D L Bowtell
A combined genetic and biochemical approach to mammalian signal transduction.
Australian and New Zealand journal of medicine 1995;25(6):845-51.
1995: David D L Bowtell; Wallace Y Langdon
The protein product of the c-cbl oncogene rapidly complexes with the EGF receptor and is tyrosine phosphorylated following EGF stimulation.
Oncogene 1995;11(8):1561-7.
1995: N G Della; David D L Bowtell; Felix Beck
Expression of Siah-2, a vertebrate homologue of Drosophila sina, in germ cells of the mouse ovary and testis.
Cell and tissue research 1995;279(2):411-9.
1993: N G Della; P V Senior; David D L Bowtell
Isolation and characterisation of murine homologues of the Drosophila seven in absentia gene (sina).
Development (Cambridge, England) 1993;117(4):1333-43.
1992: David D L Bowtell; P Fu; M Simon; P Senior
Identification of murine homologues of the Drosophila son of sevenless gene: potential activators of ras.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(14):6511-5.