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Maurizio Viale

Research Profile

Chemicals & Drugs

Living Beings

Disorders

Leukemia P388

Anatomy

Physiology

Cell Proliferation

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Drug Dose Response Relationship

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Publications

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Alessandro Balbi; Patrizio Castagnola; Rosaria Gangemi; Chiara Macciò; Mauro Mazzei; Mariangela Miele; Camillo Rosano; Cinzia Aiello; Maria Anzaldi; Maurizio Viale
Synthesis and biological evaluation of novel pyrazole derivatives with anticancer activity.
Sergio Cafaggi; E Russo; Rossana Stefani; Brunella Parodi; Gabriele Caviglioli; Greta Sillo; Angela Bisio; Cinzia Aiello; Maurizio Viale
Preparation, characterisation and preliminary antitumour activity evaluation of a novel nanoparticulate system based on a cisplatin-hyaluronate complex and N-trimethyl chitosan.
Maurizio Viale; Cinzia Cordazzo; Daniela de Totero; Roberta Budriesi; Camillo Rosano; Alberto Leoni; Pierfranco Ioan; Cinzia Aiello; Michela Croce; Aldo Andreani; Mirella Rambaldi; Patrizia Russo; Alberto Chiarini; Domenico Spinelli
Inhibition of MDR1 activity and induction of apoptosis by analogues of nifedipine and diltiazem: an in vitro analysis.

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All Publications

2011: Alessandro Balbi; Patrizio Castagnola; Rosaria Gangemi; Chiara Macciò; Mauro Mazzei; Mariangela Miele; Camillo Rosano; Cinzia Aiello; Maria Anzaldi; Maurizio Viale
Synthesis and biological evaluation of novel pyrazole derivatives with anticancer activity.
European journal of medicinal chemistry 2011;46(11):5293-309.
2011: Sergio Cafaggi; E Russo; Rossana Stefani; Brunella Parodi; Gabriele Caviglioli; Greta Sillo; Angela Bisio; Cinzia Aiello; Maurizio Viale
Preparation, characterisation and preliminary antitumour activity evaluation of a novel nanoparticulate system based on a cisplatin-hyaluronate complex and N-trimethyl chitosan.
Investigational new drugs 2011;29(3):443-55.
2011: Maurizio Viale; Cinzia Cordazzo; Daniela de Totero; Roberta Budriesi; Camillo Rosano; Alberto Leoni; Pierfranco Ioan; Cinzia Aiello; Michela Croce; Aldo Andreani; Mirella Rambaldi; Patrizia Russo; Alberto Chiarini; Domenico Spinelli
Inhibition of MDR1 activity and induction of apoptosis by analogues of nifedipine and diltiazem: an in vitro analysis.
Investigational new drugs 2011;29(1):98-109.
2009: Maurizio Viale; Cinzia Cordazzo; Barbara Cosimelli; Daniela de Totero; Patrizio Castagnola; Cinzia Aiello; Elda Severi; Giovanni Petrillo; Maurizio Cianfriglia; Domenico Spinelli
Inhibition of MDR1 activity in vitro by a novel class of diltiazem analogues: toward new candidates.
Journal of medicinal chemistry 2009;52(2):259-66.
2008: Maurizio Viale; Giovanni Petrillo; Massimo Maccagno; Patrizio Castagnola; Cinzia Aiello; Cinzia Cordazzo; Maria A Mariggiò; Sushilkumar A Jadhav; Lara Bianchi; Giuseppe Leto; Egon Rizzato; Alessandro Poggi; Domenico Spinelli
Sensitivity of different resistant tumour cell lines to the two novel compounds (2Z,4E)-2-methylsulfanyl-5-(1-naphthyl)-4-nitro-2,4-pentadienoate and (1E,3E)-1,4-bis(2-naphthyl)-2,3-dinitro-1,3-butadiene.
European journal of pharmacology 2008;588(1):47-51.
2008: Chiara Fenoglio; A Grosso; G Petrillo; Eleonora Boncompagni; C Aiello; C Cordazzo; Domenico Spinelli; E Ognio; M A Mariggio; A Cassano; Maurizio Viale
A histochemical approach to the evaluation of the in vivo cytotoxicity of the nitrobutadienes (1E,3E)-1,4-bis(1-naphthyl)-2,3-dinitro-1,3-butadiene and methyl (2Z,4E)-2-methylsulfanyl-5-(1-naphthyl)-4-nitro-2,4-pentadienoate in mice liver and kidney.
Anticancer research 2008;28(2A):813-23.
2008: Giovanni Petrillo; Maria A Mariggiò; Cinzia Aiello; Cinzia Cordazzo; Chiara Fenoglio; Stefano Morganti; Michela Croce; Egon Rizzato; Domenico Spinelli; Massimo Maccagno; Lara Bianchi; Claudia Prevosto; Cinzia Tavani; Maurizio Viale
Design, synthesis, and in vitro evaluation of new naphthylnitrobutadienes with potential antiproliferative activity: toward a structure/activity correlation.
Bioorganic & medicinal chemistry 2008;16(1):240-7.
2007: Giovanni Petrillo; Chiara Fenoglio; Emanuela Ognio; Cinzia Aiello; Domenico Spinelli; Maria A Mariggiò; Massimo Maccagno; Stefano Morganti; Cinzia Cordazzo; Maurizio Viale
Naphthylnitrobutadienes as pharmacologically active molecules: evaluation of the in vivo antitumour activity.
Investigational new drugs 2007;25(6):535-44.
2007: Maurizio Viale; Giovanni Petrillo; Cinzia Aiello; Chiara Fenoglio; Cinzia Cordazzo; Maria A Mariggiò; Amalia Cassano; Claudia Prevosto; Emanuela Ognio; Massimo Maccagno; Lara Bianchi; Rita Vaccarone; Egon Rizzato; Domenico Spinelli
Synthesis, in vitro activity and in vivo toxicity of the new 2,3-dinitrobutadiene derivative (1E,3E)-1,4-bis(2-naphthyl)-2,3-dinitro-1,3-butadiene.
Pharmacological research : the official journal of the Italian Pharmacological Society 2007;56(4):318-28.
2007: Sergio Cafaggi; E Russo; R Stefani; Riccardo Leardi; Gabriele Caviglioli; Brunella Parodi; Gaetano Bignardi; D De Totero; Cinzia Aiello; Maurizio Viale
Preparation and evaluation of nanoparticles made of chitosan or N-trimethyl chitosan and a cisplatin-alginate complex.
Journal of controlled release : official journal of the Controlled Release Society 2007;121(1-2):110-23.
2006: Emanuela Ognio; Barbara Chiavarina; Miroslav Peterka; Maria A Mariggiò; Maurizio Viale
Study of feasibility of the treatment with procainamide hydrochloride and cisplatin in pregnant mice.
Chemico-biological interactions 2006;164(3):232-40.
2005: Chiara Fenoglio; Eleonora Boncompagni; Barbara Chiavarina; Sergio Cafaggi; Michele Cilli; Maurizio Viale
Morphological and histochemical evidence of the protective effect of procainamide hydrochloride on tissue damage induced by repeated administration of low doses of cisplatin.
Anticancer research 2005;25(6B):4123-8.
2005: Carlo Dell'Erba; Barbara Chiavarina; Chiara Fenoglio; Giovanni Petrillo; Cinzia Cordazzo; Eleonora Boncompagni; Domenico Spinelli; Emanuela Ognio; Cinzia Aiello; Maria A Mariggiò; Maurizio Viale
Inhibition of cell proliferation, cytotoxicity and induction of apoptosis of 1,4-bis(1-naphthyl)-2,3-dinitro-1,3-butadiene in gastrointestinal tumour cell lines and preliminary evaluation of its toxicity in vivo.
Pharmacological research : the official journal of the Italian Pharmacological Society 2005;52(3):271-82.
2005: Jitka Kuncová; Zdenek Kostrouch; Maurizio Viale; Roberto P Revoltella; Václav Mandys
Expression of CD44v6 correlates with cell proliferation and cellular atypia in urothelial carcinoma cell lines 5637 and HT1197.
Folia biologica 2005;51(1):3-11.
2004: Maurizio Viale; Maria A Mariggiò; Massimo Ottone; Barbara Chiavarina; Angela Vinella; Claudia Prevosto; Carlo Dell'Erba; Giovanni Petrillo; Marino Novi
Preliminary evaluation in vitro of the inhibition of cell proliferation, cytotoxicity and induction of apoptosis by 1,4-bis(1-naphthyl)-2,3-dinitro-1,3-butadiene.
Investigational new drugs 2004;22(4):359-67.
2004: Emanuela Ognio; Barbara Chiavarina; Gabriele Caviglioli; Maddalena Lapide; Maurizio Viale
Transplacental passage of Pt after treatment with the new triamine complex cis-diaminechloro-[2-(diethylamino) ethyl 4-amino-benzoate, N4]-chloride platinum (II) monohydrochloride monohydrate.
Archives of toxicology 2004;78(10):584-8.
2004: Marino Novi; Massimo Ottone; Carlo Dell'Erba; Federica Barbieri; Barbara Chiavarina; Massimo Maccagno; Maurizio Viale
1,4-Bis(1-naphthyl)-2,3-dinitro-1,3-butadiene a novel anticancer compound effective against tumor cell lines characterized by different mechanisms of resistance.
Oncology reports 2004;12(1):91-6.
2004: Maria A Mariggiò; Sergio Cafaggi; Massimo Ottone; Brunella Parodi; Maria O Vannozzi; Václav Mandys; Maurizio Viale
Inhibition of cell growth, induction of apoptosis and mechanism of action of the novel platinum compound cis-diaminechloro-[2-(diethylamino) ethyl 4-amino-benzoate, N(4)]-chloride platinum (II) monohydrochloride monohydrate.
Investigational new drugs 2004;22(1):3-16.
2003: Emanuela Ognio; Maddalena Lapide; Massimo Ottone; Václav Mandys; Miroslav Peterka; Brunella Parodi; Maurizio Viale
Embryo-lethal and teratogenic effect of the new platinum compound DPR in pregnant mice.
Archives of toxicology 2003;77(10):584-90.
2003: Maria O Vannozzi; Massimo Ottone; Maria A Mariggiò; Sergio Cafaggi; Brunella Parodi; Michele Cilli; Edward Lindup; Maurizio Viale
Pharmacokinetic and pharmacodynamic analysis of platinum after combined treatment of cisplatin and procainamide hydrochloride in mice bearing P388 leukemia.
Anticancer research 2003;23(2B):1509-16.
2003: Maurizio Viale; Silvia Minetti; Massimo Ottone; Roberto Lerza; Brunella Parodi; Ivo Pannacciulli
Preclinical in vitro evaluation of hematotoxicity of the cisplatin-procaine complex DPR.
Anti-cancer drugs 2003;14(2):163-6.
2002: Chiara Fenoglio; Clodomiro Andrea Boicelli; Massimo Ottone; Concetta Addario; Patrizia Chiari; Maurizio Viale
Protective effect of procaine hydrochloride on cisplatin-induced alterations in rat kidney.
Anti-cancer drugs 2002;13(10):1043-54.
2002: Federica Barbieri; Maurizio Viale; Fabio Sparatore; Gennaro Schettini; Anna Favre; Cristina Bruzzo; Federica Novelli; Angela Alama
Antitumor activity of a new orally active organotin compound: a preliminary study in murine tumor models.
Anti-cancer drugs 2002;13(6):599-604.
2002: Antonio Zicca; Sergio Cafaggi; Maria A Mariggiò; Maria O Vannozzi; Massimo Ottone; Vittorio Bocchini; Gabriele Caviglioli; Maurizio Viale
Reduction of cisplatin hepatotoxicity by procainamide hydrochloride in rats.
European journal of pharmacology 2002;442(3):265-72.
2002: D Civalleri; Maria O Vannozzi; Franco Decian; G Lunardi; M Steinweg; I Pastrone; Maurizio Viale; M Esposito
Intraperitoneal mitoxantrone: a feasibility and pharmacokinetic study.
European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology 2002;28(2):172-9.
2002: Miroslav Peterka; Václav Mandys; Maurizio Viale; Sergio Cafaggi; Renata Peterková; M Esposito
Embryotoxicity of cisplatin and a cisplatin-procaine complex (DPR) studied in chick embryo.
Neoplasma 2002;49(6):394-400.
2001: Maurizio Viale; M O Vánnozzi; Václav Mandys; M Esposito
Time-dependent influence of procaine hydrochloride on cisplatin antitumor activity in P388 tumor bearing mice.
Anticancer research 2001;21(1A):485-7.
2000: Maurizio Viale; Maria O Vannozzi; I Pastrone; Maria A Mariggiò; Antonio Zicca; A Cadoni; Sergio Cafaggi; G Tolino; G Lunardi; D Civalleri; W Edward Lindup; M Esposito
Reduction of cisplatin nephrotoxicity by procainamide: does the formation of a cisplatin-procainamide complex play a role?
The Journal of pharmacology and experimental therapeutics 2000;293(3):829-36.
2000: Marco Venturini; G Lunardi; Lucia Del Mastro; Maria O Vannozzi; G Tolino; Gianmauro Numico; Maurizio Viale; I Pastrone; C Angiolini; Gianfilippo Bertelli; M Straneo; Riccardo Rosso; M Esposito
Sequence effect of epirubicin and paclitaxel treatment on pharmacokinetics and toxicity.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2000;18(10):2116-25.
2000: Federica Barbieri; Maurizio Viale; Fabio Sparatore; A Favre; M Cagnoli; Cristina Bruzzo; Federica Novelli; Angela Alama
Cytotoxicity in vitro and preliminary antitumor activity in vivo of a novel organotin compound.
Anticancer research 2000;20(2A):977-80.
1999: JG Zhang; Maurizio Viale; M Esposito; W Edward Lindup
Tiopronin protects against the nephrotoxicity of cisplatin in the rat.
Human & experimental toxicology 1999;18(12):713-7.
1999: M Esposito; Marco Venturini; Maria O Vannozzi; G Tolino; G Lunardi; Ornella Garrone; C Angiolini; Maurizio Viale; M Bergaglio; Lucia Del Mastro; Riccardo Rosso
Comparative effects of paclitaxel and docetaxel on the metabolism and pharmacokinetics of epirubicin in breast cancer patients.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1999;17(4):1132.
1999: Maurizio Viale; JG Zhang; I Pastrone; Maria A Mariggiò; M Esposito; W Edward Lindup
Cisplatin combined with tiopronin or sodium thiosulfate: cytotoxicity in vitro and antitumor activity in vivo.
Anti-cancer drugs 1999;10(4):419-28.
1998: Václav Mandys; Maurizio Viale; J Vrana; Sergio Cafaggi; M Esposito
Neurotoxic effect of cisplatin and the cisplatin-procaine complex DPR studied in organotypic cultures of chick embryonic dorsal root ganglia.
Anti-cancer drugs 1998;9(7):659-63.
1998: Maurizio Viale; I Pastrone; C Pellecchia; Maria O Vannozzi; Sergio Cafaggi; M Esposito
Combination of cisplatin-procaine complex DPR with anticancer drugs increases cytotoxicity against ovarian cancer cell lines.
Anti-cancer drugs 1998;9(5):457-63.
1998: Gianmauro Numico; Marco Benasso; Maria O Vannozzi; Marco Merlano; Riccardo Rosso; Maurizio Viale; M Esposito
Hydration regimen and hematological toxicity of a cisplatin-based chemotherapy regimen. Clinical observations and pharmacokinetic analysis.
Anticancer research 1998;18(2B):1313-8.
1998: I Pastrone; Maurizio Viale; Sergio Cafaggi; Maria A Mariggiò; A Parodi; M Esposito
Effect of the cisplatin-procaine complex DPR in combination with several anticancer agents on murine P388 leukemic cells in vitro and in vivo.
Investigational new drugs 1998;16(4):297-302.
1997: Roberto Lerza; Maria O Vannozzi; G Tolino; Maurizio Viale; paola taddei; Giuseppe Bogliolo; A Cerruti; G Castello; Manlio Mencoboni; G Reggiardo; Ivo Pannacciulli; M Esposito
Carboplatin and cisplatin pharmacokinetics after intrapleural combination treatment in patients with malignant pleural effusion.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 1997;8(4):385-91.
1996: Maurizio Viale; Maria O Vannozzi; F Merlo; Sergio Cafaggi; Brunella Parodi; M Esposito
Cisplatin combined with the new cisplatin-procaine complex DPR: in vitro and in vivo studies.
European journal of cancer (Oxford, England : 1990) 1996;32A(13):2327-33.
1996: M Esposito; Maurizio Viale; Maria O Vannozzi; Antonio Zicca; A Cadoni; F Merlo; L Gogioso
Effect of the antiarrhythmic drug procainamide on the toxicity and antitumor activity of cis-diamminedichloroplatinum(II).
Toxicology and applied pharmacology 1996;140(2):370-7.
1995: M Esposito; Maria O Vannozzi; Maurizio Viale; C Pellecchia; D Civalleri; L Gogioso
Effect of para-aminobenzoic acid on the pharmacokinetics and urinary excretion of cis-diamminedichloroplatinum(II) in rats.
Anticancer research 1995;15(6B):2541-7.
1995: Brunella Parodi; M Esposito; Maurizio Viale; Sergio Cafaggi; Maria O Vannozzi
Chemical and biological properties of a new cis-diammineplatinum (II) complex containing para-aminobenzoic acid as amino ligand.
Anticancer research 1995;15(3):895-9.
1995: Maurizio Viale; Sergio Cafaggi; Brunella Parodi; M Esposito
Cytotoxicity and cellular accumulation of a new cis-diammineplatinum (II) complex containing procaine in murine L1210 cells sensitive and resistant to cis-diamminedichloroplatinum (II).
Cancer chemotherapy and pharmacology 1995;35(5):371-6.
1994: Sergio Cafaggi; M Esposito; Brunella Parodi; Maurizio Viale
A water-soluble 1,2-diaminocyclohexaneplatinum(II) complex containing procaine hydrochloride: synthesis and antiproliferative activity in vitro.
Die Pharmazie 1994;49(8):617-8.
1994: C Cantoni; A Cambiaggi; Sabrina Sforzini; Alessandro Poggi; Maurizio Viale; Roberto Biassoni; Silvano Ferrini
Characterization of a cyclosporin A-sensitive activation pathway in cultured T and natural killer cells.
Scandinavian journal of immunology 1994;39(4):373-9.
1993: M Esposito; Maria O Vannozzi; Maurizio Viale; RA Fulco; P Collecchi; F Merlo; Luigi D'Ambra; Antonio Zicca; A Cadoni; M C Poirier
Para-aminobenzoic acid suppression of cis-diamminedichloroplatinum(II) nephrotoxicity.
Carcinogenesis 1993;14(12):2595-9.
1993: M Esposito; Maria O Vannozzi; Maurizio Viale; C Pellecchia; F Merlo; A Cadoni; Sergio Cafaggi; Brunella Parodi; Roberto Lerza; M C Poirier
Cis-diamminedichloroplatinum (II)-procaine pharmacokinetic interaction in mice bearing P388 leukemia.
Anticancer research 1993;13(5A):1511-6.
1992: Sergio Cafaggi; M Esposito; Brunella Parodi; Maria O Vannozzi; Maurizio Viale; C Pellecchia; RA Fulco; F Merlo; Antonio Zicca; A Cadoni
Synthesis and antitumor activity of a new cis-diammineplatinum (II) complex containing procaine hydrochloride.
Anticancer research 1992;12(6B):2285-92.
1992: Maurizio Viale; Silvano Ferrini; Andrea Bacigalupo
TCR gamma/delta positive lymphocytes after allogeneic bone marrow transplantation.
Bone marrow transplantation 1992;10(3):249-53.
1992: Maurizio Viale; A Bacigalupo; Silvano Ferrini; Annamaria Bevilacqua
Effect of cyclosporin A on T cell clones from severe aplastic anemia: differential sensitivity of TNF and GM-CSF production.
Haematologica 1992;77(3):237-42.
1990: Maurizio Viale; Silvano Ferrini; S Serrano; D Serrano; Andrea Ardizzoni; Annamaria Bevilacqua
Peripheral blood and tumor infiltrating lymphocytes in non-small cell lung cancer: analysis at the population and clonal level.
Tumori 1990;76(5):488-94.
1989: Silvano Ferrini; Daniela Zarcone; Maurizio Viale; G Cerruti; R Millo; Alessandro Moretta; Carlo E Grossi
Morphologic and functional characterization of human peripheral blood T cells expressing the T cell receptor gamma/delta.
European journal of immunology 1989;19(7):1183-8.
1989: Maurizio Viale; Silvano Ferrini; A Bacigalupo; Roberto Biassoni; A Marmont; Annamaria Bevilacqua
Phenotypic and functional characterization of T cell clones following allogeneic bone marrow transplantation.
Transplantation 1989;47(5):838-43.
1984: A Bacigalupo; F Di Giorgio; F Frassoni; M T Van Lint; M R Raffo; L Gogioso; Maurizio Viale; A M Marmont
Cyclosporin A serum and blood levels in marrow graft recipients: correlation with administered dose, serum creatinine and graft-versus-host disease.
Acta haematologica 1984;72(3):155-62.