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Mauno Vihinen

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Publications

TOP 3
Samarghitean Crina; Vihinen Mauno
Bioinformatics services related to diagnosis of primary immunodeficiencies.
Qi Chun-Jian; Zheng Lu; Ma Hong-Bing; Fei Min; Qian Ke-Qing; Shen Bai-Rong; Wu Chang-Ping; Vihinen Mauno; Zhang Xue-Guang
A novel mutation in CD40 and its functional characterization.
Liu Wennuan; Laitinen Sari; Khan Sofia; Vihinen Mauno; Kowalski Jeanne; Yu Guoqiang; Chen Li; Ewing Charles M; Eisenberger Mario A; Carducci Michael A; Nelson William G; Yegnasubramanian Srinivasan; Luo Jun; Wang Yue; Xu Jianfeng; Isaacs William B; Visakorpi Tapio; Bova G Steven
Copy number analysis indicates monoclonal origin of lethal metastatic prostate cancer.

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All Publications

2009: Samarghitean Crina; Vihinen Mauno
Bioinformatics services related to diagnosis of primary immunodeficiencies.
Current opinion in allergy and clinical immunology 2009;9(6):531-6.
2009: Qi Chun-Jian; Zheng Lu; Ma Hong-Bing; Fei Min; Qian Ke-Qing; Shen Bai-Rong; Wu Chang-Ping; Vihinen Mauno; Zhang Xue-Guang
A novel mutation in CD40 and its functional characterization.
Human mutation 2009;30(6):985-94.
2009: Liu Wennuan; Laitinen Sari; Khan Sofia; Vihinen Mauno; Kowalski Jeanne; Yu Guoqiang; Chen Li; Ewing Charles M; Eisenberger Mario A; Carducci Michael A; Nelson William G; Yegnasubramanian Srinivasan; Luo Jun; Wang Yue; Xu Jianfeng; Isaacs William B; Visakorpi Tapio; Bova G Steven
Copy number analysis indicates monoclonal origin of lethal metastatic prostate cancer.
Nature medicine 2009;15(5):559-65.
2009: Thusberg Janita; Vihinen Mauno
Pathogenic or not? And if so, then how? Studying the effects of missense mutations using bioinformatics methods.
Human mutation 2009;30(5):703-14.
2009: Stenberg Kaj A E; Vihinen Mauno
Crystal structure of a 1.6-hexanediol bound tetrameric form of Escherichia coli lac-repressor refined to 2.1 A resolution.
Proteins 2009;75(3):748-59.
2009: den Dunnen Johan T; Sijmons Rolf H; Andersen Paal S; Vihinen Mauno; Beckmann Jacques S; Rossetti Sandro; Talbot C Conover; Hardison Ross C; Povey Sue; Cotton Richard G H
Sharing data between LSDBs and central repositories.
Human mutation 2009;30(4):493-5.
2009: Mohamed Abdalla J; Yu Liang; Bäckesjö Carl-Magnus; Vargas Leonardo; Faryal Rani; Aints Alar; Christensson Birger; Berglöf Anna; Vihinen Mauno; Nore Beston F; Smith C I Edvard
Bruton's tyrosine kinase (Btk): function, regulation, and transformation with special emphasis on the PH domain.
Immunological reviews 2009;228(1):58-73.
2009: Ortutay Csaba; Vihinen Mauno
Identification of candidate disease genes by integrating Gene Ontologies and protein-interaction networks: case study of primary immunodeficiencies.
Nucleic acids research 2009;37(2):622-8.
2009: Vihinen Mauno
Problems with anti-plagiarism database.
Nature 2009;457(7225):26.
2009: Laurila Kirsti; Vihinen Mauno
Prediction of disease-related mutations affecting protein localization.
BMC genomics 2009;10():122.
2009: Ortutay Csaba; Vihinen Mauno
Immunome knowledge base (IKB): an integrated service for immunome research.
BMC immunology 2009;10():3.
2008: Ahola Virpi; Aittokallio Tero; Vihinen Mauno; Uusipaikka Esa
Model-based prediction of sequence alignment quality.
Bioinformatics (Oxford, England) 2008;24(19):2165-71.
2008: Lappalainen Ilkka; Thusberg Janita; Shen Bairong; Vihinen Mauno
Genome wide analysis of pathogenic SH2 domain mutations.
Proteins 2008;72(2):779-92.
2008: Kivioja Teemu; Tiirikka Timo; Siermala Markku; Vihinen Mauno
Dynamic covariation between gene expression and genome characteristics.
Gene 2008;410(1):53-66.
2008: Cotton R G H; Auerbach A D; Beckmann J S; Blumenfeld O O; Brookes A J; Brown A F; Carrera P; Cox D W; Gottlieb B; Greenblatt M S; Hilbert P; Lehvaslaiho H; Liang P; Marsh S; Nebert D W; Povey S; Rossetti S; Scriver C R; Summar M; Tolan D R; Verma I C; Vihinen M; den Dunnen J T
Recommendations for locus-specific databases and their curation.
Human mutation 2008;29(1):2-5.
2008: Shen Bairong; Bai Jinwei; Vihinen Mauno
Physicochemical feature-based classification of amino acid mutations.
Protein engineering, design & selection : PEDS 2008;21(1):37-44.
2008: Pärssinen Jenita; Alarmo Emma-Leena; Khan Sofia; Karhu Ritva; Vihinen Mauno; Kallioniemi Anne
Identification of differentially expressed genes after PPM1D silencing in breast cancer.
Cancer letters 2008;259(1):61-70.
2008: Ortutay Csaba; Nore Beston F; Vihinen Mauno; Smith C I Edvard
Phylogeny of Tec family kinases identification of a premetazoan origin of Btk, Bmx, Itk, Tec, Txk, and the Btk regulator SH3BP5.
Advances in genetics 2008;64():51-80.
2008: Fan Yue-Mei; Karhunen Pekka J; Levula Mari; Ilveskoski Erkki; Mikkelsson Jussi; Kajander Olli A; Järvinen Otso; Oksala Niku; Thusberg Janita; Vihinen Mauno; Salenius Juha-Pekka; Kytömäki Leena; Soini Juhani T; Laaksonen Reijo; Lehtimäki Terho
Expression of sterol regulatory element-binding transcription factor (SREBF) 2 and SREBF cleavage-activating protein (SCAP) in human atheroma and the association of their allelic variants with sudden cardiac death.
Thrombosis journal 2008;6():17.
2008: Ortutay Csaba; Vihinen Mauno
PseudoGeneQuest - service for identification of different pseudogene types in the human genome.
BMC bioinformatics 2008;9():299.
2008: Ortutay Csaba; Vihinen Mauno
Efficiency of the immunome protein interaction network increases during evolution.
Immunome research 2008;4():4.
2007: Rannikko Kathryn; Ortutay Csaba; Vihinen Mauno
Immunity genes and their orthologs: a multi-species database.
International immunology 2007;19(12):1361-70.
2007: Cotton R G H; Auerbach A D; Brown A F; Carrera P; Christodoulou J; Claustres M; Compton J; Cox D W; De Baere E; den Dunnen J T; Greenblatt M; Fujiwara M; Hilbert P; Jani A; Lehvaslaiho H; Nebert D W; Verma I; Vihinen M;
A structured simple form for ordering genetic tests is needed to ensure coupling of clinical detail (phenotype) with DNA variants (genotype) to ensure utility in publication and databases.
Human mutation 2007;28(10):931-2.
2007: Ollila Juha; Vihinen Mauno
Immunological systems biology: gene expression analysis of B-cell development in Ramos B-cells.
Molecular immunology 2007;44(14):3537-51.
2007: Giardine Belinda; Riemer Cathy; Hefferon Tim; Thomas Daryl; Hsu Fan; Zielenski Julian; Sang Yunhua; Elnitski Laura; Cutting Garry; Trumbower Heather; Kern Andrew; Kuhn Robert; Patrinos George P; Hughes Jim; Higgs Doug; Chui David; Scriver Charles; Phommarinh Manyphong; Patnaik Santosh K; Blumenfeld Olga; Gottlieb Bruce; Vihinen Mauno; Väliaho Jouni; Kent Jim; Miller Webb; Hardison Ross C
PhenCode: connecting ENCODE data with mutations and phenotype.
Human mutation 2007;28(6):554-62.
2007: Ortutay Csaba; Siermala Markku; Vihinen Mauno
Molecular characterization of the immune system: emergence of proteins, processes, and domains.
Immunogenetics 2007;59(5):333-48.
2007: Thusberg J; Vihinen M
The structural basis of hyper IgM deficiency - CD40L mutations.
Protein engineering, design & selection : PEDS 2007;20(3):133-41.
2007: Khan Sofia; Vihinen Mauno
Spectrum of disease-causing mutations in protein secondary structures.
BMC structural biology 2007;7():56.
2007: Pajunen Maria; Turakainen Hilkka; Poussu Eini; Peränen Johan; Vihinen Mauno; Savilahti Harri
High-precision mapping of protein protein interfaces: an integrated genetic strategy combining en masse mutagenesis and DNA-level parallel analysis on a yeast two-hybrid platform.
Nucleic acids research 2007;35(16):e103.
2007: Samarghitean Crina; Väliaho Jouni; Vihinen Mauno
IDR knowledge base for primary immunodeficiencies.
Immunome research 2007;3():6.
2007: Ortutay Csaba; Siermala Markku; Vihinen Mauno
ImmTree: database of evolutionary relationships of genes and proteins in the human immune system.
Immunome research 2007;3():4.
2006: Ortutay Csaba; Vihinen Mauno
Immunome: a reference set of genes and proteins for systems biology of the human immune system.
Cellular immunology 2006;244(2):87-9.
2006: Piirilä Hilkka; Väliaho Jouni; Vihinen Mauno
Immunodeficiency mutation databases (IDbases).
Human mutation 2006;27(12):1200-8.
2006: Thusberg Janita; Vihinen Mauno
Bioinformatic analysis of protein structure-function relationships: case study of leukocyte elastase (ELA2) missense mutations.
Human mutation 2006;27(12):1230-43.
2006: Väliaho Jouni; Smith C I Edvard; Vihinen Mauno
BTKbase: the mutation database for X-linked agammaglobulinemia.
Human mutation 2006;27(12):1209-17.
2006: Salonen Johanna M; Valmu Leena; Rönnholm Gunilla; Kalkkinen Nisse; Vihinen Mauno
Proteome analysis of B-cell maturation.
Proteomics 2006;6(19):5152-68.
2006: Mononen Nina; Seppälä Eija H; Duggal Priya; Autio Ville; Ikonen Tarja; Ellonen Pekka; Saharinen Juha; Saarela Janna; Vihinen Mauno; Tammela Teuvo L J; Kallioniemi Olli; Bailey-Wilson Joan E; Schleutker Johanna
Profiling genetic variation along the androgen biosynthesis and metabolism pathways implicates several single nucleotide polymorphisms and their combinations as prostate cancer risk factors.
Cancer research 2006;66(2):743-7.
2006: Ahola Virpi; Aittokallio Tero; Vihinen Mauno; Uusipaikka Esa
A statistical score for assessing the quality of multiple sequence alignments.
BMC bioinformatics 2006;7():484.
2005: Hilvo Mika; Tolvanen Martti; Clark Amy; Shen Bairong; Shah Gul N; Waheed Abdul; Halmi Piia; Hänninen Milla; Hämäläinen Jonna M; Vihinen Mauno; Sly William S; Parkkila Seppo
Characterization of CA XV, a new GPI-anchored form of carbonic anhydrase.
The Biochemical journal 2005;392(Pt 1):83-92.
2005: Ortutay Csaba; Väliaho Jouni; Stenberg Kaj; Vihinen Mauno
KinMutBase: a registry of disease-causing mutations in protein kinase domains.
Human mutation 2005;25(5):435-42.
2005: Ollila Juha; Vihinen Mauno
B cells.
The international journal of biochemistry & cell biology 2005;37(3):518-23.
2005: Lindvall Jessica M; Blomberg K Emelie M; Väliaho Jouni; Vargas Leonardo; Heinonen Juhana E; Berglöf Anna; Mohamed Abdalla J; Nore Beston F; Vihinen Mauno; Smith C I Edvard
Bruton's tyrosine kinase: cell biology, sequence conservation, mutation spectrum, siRNA modifications, and expression profiling.
Immunological reviews 2005;203():200-15.
2005: Hyyrö Heikki; Juhola Martti; Vihinen Mauno
On exact string matching of unique oligonucleotides.
Computers in biology and medicine 2005;35(2):173-81.
2005: Sharabiani Mansour Taghavi Azar; Siermala Markku; Lehtinen Tommi O; Vihinen Mauno
Dynamic covariation between gene expression and proteome characteristics.
BMC bioinformatics 2005;6():215.
2005: Hyyrö Heikki; Juhola Martti; Vihinen Mauno
Genome-wide selection of unique and valid oligonucleotides.
Nucleic acids research 2005;33(13):e115.
2005: Väliaho Jouni; Riikonen Pentti; Vihinen Mauno
Distribution of immunodeficiency fact files with XML--from Web to WAP.
BMC medical informatics and decision making 2005;5():21.
2004: Ferrer Anna; Ollila Juha; Tobin Gerard; Nagy Bálint; Thunberg Ulf; Aalto Yan; Vihinen Mauno; Vilpo Juhani; Rosenquist Richard; Knuutila Sakari
Different gene expression in immunoglobulin-mutated and immunoglobulin-unmutated forms of chronic lymphocytic leukemia.
Cancer genetics and cytogenetics 2004;153(1):69-72.
2004: Vitikainen Marika; Lappalainen Ilkka; Seppala Raili; Antelmann Haike; Boer Harry; Taira Suvi; Savilahti Harri; Hecker Michael; Vihinen Mauno; Sarvas Matti; Kontinen Vesa P
Structure-function analysis of PrsA reveals roles for the parvulin-like and flanking N- and C-terminal domains in protein folding and secretion in Bacillus subtilis.
The Journal of biological chemistry 2004;279(18):19302-14.
2004: Shen Bairong; Vihinen Mauno
Conservation and covariance in PH domain sequences: physicochemical profile and information theoretical analysis of XLA-causing mutations in the Btk PH domain.
Protein engineering, design & selection : PEDS 2004;17(3):267-76.
2004: Poussu Eini; Vihinen Mauno; Paulin Lars; Savilahti Harri
Probing the alpha-complementing domain of E. coli beta-galactosidase with use of an insertional pentapeptide mutagenesis strategy based on Mu in vitro DNA transposition.
Proteins 2004;54(4):681-92.
2004: Halonen Maria; Kangas Hannele; Rüppell Taina; Ilmarinen Tanja; Ollila Juha; Kolmer Meelis; Vihinen Mauno; Palvimo Jorma; Saarela Jani; Ulmanen Ismo; Eskelin Petra
APECED-causing mutations in AIRE reveal the functional domains of the protein.
Human mutation 2004;23(3):245-57.
2004: Samarghitean Crina; Väliaho Jouni; Vihinen Mauno
Online registry of genetic and clinical immunodeficiency diagnostic laboratories, IDdiagnostics.
Journal of clinical immunology 2004;24(1):53-61.
2004: Lehtonen Jonna; Shen Bairong; Vihinen Mauno; Casini Angela; Scozzafava Andrea; Supuran Claudiu T; Parkkila Anna-Kaisa; Saarnio Juha; Kivelä Antti J; Waheed Abdul; Sly William S; Parkkila Seppo
Characterization of CA XIII, a novel member of the carbonic anhydrase isozyme family.
The Journal of biological chemistry 2004;279(4):2719-27.
2004: Ahola Virpi; Aittokallio Tero; Uusipaikka Esa; Vihinen Mauno
Statistical methods for identifying conserved residues in multiple sequence alignment.
Statistical applications in genetics and molecular biology 2004;3():Article28.
2004: Giurcaneanu Ciprian Doru; Tabus Ioan; Astola Jaakko; Ollila Juha; Vihinen Mauno
Fast iterative gene clustering based on information theoretic criteria for selecting the cluster structure.
Journal of computational biology : a journal of computational molecular cell biology 2004;11(4):660-82.
2003: Vihinen Mauno
Signal transduction-related bioinformatics services.
Briefings in bioinformatics 2003;4(4):325-31.
2003: Ahola Virpi; Aittokallio Tero; Uusipaikka Esa; Vihinen Mauno
Efficient estimation of emission probabilities in profile hidden Markov models.
Bioinformatics (Oxford, England) 2003;19(18):2359-68.
2003: Shen Bairong; Vihinen Mauno
RankViaContact: ranking and visualization of amino acid contacts.
Bioinformatics (Oxford, England) 2003;19(16):2161-2.
2003: Casas Sílvia; Ollila Juha; Aventín Anna; Vihinen Mauno; Sierra Jorge; Knuutila Sakari
Changes in apoptosis-related pathways in acute myelocytic leukemia.
Cancer genetics and cytogenetics 2003;146(2):89-101.
2003: Ollila J; Vihinen M
Stimulation-induced gene expression in Ramos B-cells.
Genes and immunity 2003;4(5):343-50.
2003: Saharinen Pipsa; Vihinen Mauno; Silvennoinen Olli
Autoinhibition of Jak2 tyrosine kinase is dependent on specific regions in its pseudokinase domain.
Molecular biology of the cell 2003;14(4):1448-59.
2002: Lappalainen Ilkka; Vihinen Mauno
Structural basis of ICF-causing mutations in the methyltransferase domain of DNMT3B.
Protein engineering 2002;15(12):1005-14.
2002: Riikonen Pentti; Boberg Jorma; Salakoski Tapio; Vihinen Mauno
Mobile access to biological databases on the Internet.
IEEE transactions on bio-medical engineering 2002;49(12):1477-9.
2002: Okoh Michael P; Kainulainen Leena; Heiskanen Kaarina; Isa M Nizam; Varming Kim; Ruuskanen Olli; Vihinen Mauno
Novel insertions of Bruton tyrosine kinase in patients with X-linked agammaglobulinemia.
Human mutation 2002;20(6):480-1.
2002: Hyytinen Eija-R; Haapala Kyllikki; Thompson James; Lappalainen Ilkka; Roiha Mikko; Rantala Immo; Helin Heikki J; Jänne Olli A; Vihinen Mauno; Palvimo Jorma J; Koivisto Pasi A
Pattern of somatic androgen receptor gene mutations in patients with hormone-refractory prostate cancer.
Laboratory investigation; a journal of technical methods and pathology 2002;82(11):1591-8.
2002: Larramendy Marcelo L; Niini Tarja; Elonen Erkki; Nagy Bálint; Ollila Juha; Vihinen Mauno; Knuutila Sakari
Overexpression of translocation-associated fusion genes of FGFRI, MYC, NPMI, and DEK, but absence of the translocations in acute myeloid leukemia. A microarray analysis.
Haematologica 2002;87(6):569-77.
2002: Okoh Michael P; Vihinen Mauno
Interaction between Btk TH and SH3 domain.
Biopolymers 2002;63(5):325-34.
2002: Väliaho Jouni; Pusa Marianne; Ylinen Tuomo; Vihinen Mauno
IDR: the ImmunoDeficiency Resource.
Nucleic acids research 2002;30(1):232-4.
2002: Ollila Juha; Vihinen Mauno
Microarray analysis of B-cell stimulation.
Vitamins and hormones 2002;64():77-99.
2001: Aalto Y; El-Rifa W; Vilpo L; Ollila J; Nagy B; Vihinen M; Vilpo J; Knuutila S
Distinct gene expression profiling in chronic lymphocytic leukemia with 11q23 deletion.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2001;15(11):1721-8.
2001: Notarangelo L D; Mella P; Jones A; de Saint Basile G; Savoldi G; Cranston T; Vihinen M; Schumacher R F
Mutations in severe combined immune deficiency (SCID) due to JAK3 deficiency.
Human mutation 2001;18(4):255-63.
2001: Riikonen P; Boberg J; Salakoski T; Vihinen M
BioWAP, mobile Internet service for bioinformatics.
Bioinformatics (Oxford, England) 2001;17(9):855-6.
2001: Siermala M; Juhola M; Vihinen M
On preprocessing of protein sequences for neural network prediction of polyproline type II secondary structures.
Computers in biology and medicine 2001;31(5):385-98.
2001: Nars M; Vihinen M
Coevolution of the domains of cytoplasmic tyrosine kinases.
Molecular biology and evolution 2001;18(3):312-21.
2001: Hansson H; Okoh M P; Smith C I; Vihinen M; Härd T
Intermolecular interactions between the SH3 domain and the proline-rich TH region of Bruton's tyrosine kinase.
FEBS letters 2001;489(1):67-70.
2001: Hyyrö H; Vihinen M; Juhola M
On approximate string matching of unique oligonucleotides.
Studies in health technology and informatics 2001;84(Pt 2):960-4.
2001: Vihinen M; Arredondo-Vega F X; Casanova J L; Etzioni A; Giliani S; Hammarström L; Hershfield M S; Heyworth P G; Hsu A P; Lähdesmäki A; Lappalainen I; Notarangelo L D; Puck J M; Reith W; Roos D; Schumacher R F; Schwarz K; Vezzoni P; Villa A; Väliaho J; Smith C I
Primary immunodeficiency mutation databases.
Advances in genetics 2001;43():103-88.
2000: Notarangelo L D; Giliani S; Mazza C; Mella P; Savoldi G; Rodriguez-Pérez C; Mazzolari E; Fiorini M; Duse M; Plebani A; Ugazio A G; Vihinen M; Candotti F; Schumacher R F
Of genes and phenotypes: the immunological and molecular spectrum of combined immune deficiency. Defects of the gamma(c)-JAK3 signaling pathway as a model.
Immunological reviews 2000;178():39-48.
2000: Väliaho J; Riikonen P; Vihinen M
Novel immunodeficiency data servers.
Immunological reviews 2000;178():177-85.
2000: Vihinen M; Mattsson P T; Smith C I
Bruton tyrosine kinase (BTK) in X-linked agammaglobulinemia (XLA).
Frontiers in bioscience : a journal and virtual library 2000;5():D917-28.
2000: Nera K P; Brockmann E; Vihinen M; Smith C I; Mattsson P T
Rational design and purification of human Bruton's tyrosine kinase SH3-SH2 protein for structure-function studies.
Protein expression and purification 2000;20(3):365-71.
2000: Korpi M; Väliaho J; Vihinen M
Structure-function effects in primary immunodeficiencies.
Scandinavian journal of immunology 2000;52(3):226-32.
2000: Vihinen M; Villa A; Mella P; Schumacher R F; Savoldi G; O'Shea J J; Candotti F; Notarangelo L D
Molecular modeling of the Jak3 kinase domains and structural basis for severe combined immunodeficiency.
Clinical immunology (Orlando, Fla.) 2000;96(2):108-18.
2000: Pitkänen J; Doucas V; Sternsdorf T; Nakajima T; Aratani S; Jensen K; Will H; Vähämurto P; Ollila J; Vihinen M; Scott H S; Antonarakis S E; Kudoh J; Shimizu N; Krohn K; Peterson P
The autoimmune regulator protein has transcriptional transactivating properties and interacts with the common coactivator CREB-binding protein.
The Journal of biological chemistry 2000;275(22):16802-9.
2000: Aapola U; Kawasaki K; Scott H S; Ollila J; Vihinen M; Heino M; Shintani A; Kawasaki K; Minoshima S; Krohn K; Antonarakis S E; Shimizu N; Kudoh J; Peterson P
Isolation and initial characterization of a novel zinc finger gene, DNMT3L, on 21q22.3, related to the cytosine-5-methyltransferase 3 gene family.
Genomics 2000;65(3):293-8.
2000: Mattsson P T; Lappalainen I; Bäckesjö C M; Brockmann E; Laurén S; Vihinen M; Smith C I
Six X-linked agammaglobulinemia-causing missense mutations in the Src homology 2 domain of Bruton's tyrosine kinase: phosphotyrosine-binding and circular dichroism analysis.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(8):4170-7.
2000: Rong S B; Väliaho J; Vihinen M
Structural basis of Bloom syndrome (BS) causing mutations in the BLM helicase domain.
Molecular medicine (Cambridge, Mass.) 2000;6(3):155-64.
2000: Lappalainen I; Giliani S; Franceschini R; Bonnefoy J Y; Duckett C; Notarangelo L D; Vihinen M
Structural basis for SH2D1A mutations in X-linked lymphoproliferative disease.
Biochemical and biophysical research communications 2000;269(1):124-30.
2000: Stenberg K A; Riikonen P T; Vihinen M
KinMutBase, a database of human disease-causing protein kinase mutations.
Nucleic acids research 2000;28(1):369-71.
2000: Siermala M; Juhola M; Vihinen M
Neural network prediction of polyproline type II secondary structures.
Studies in health technology and informatics 2000;77():475-9.
1999: Okoh M P; Vihinen M
Pleckstrin homology domains of tec family protein kinases.
Biochemical and biophysical research communications 1999;265(1):151-7.
1999: Riikonen P; Vihinen M
MUTbase: maintenance and analysis of distributed mutation databases.
Bioinformatics (Oxford, England) 1999;15(10):852-9.
1999: Stenberg K A; Riikonen P T; Vihinen M
KinMutBase, a database of human disease-causing protein kinase mutations.
Nucleic acids research 1999;27(1):362-4.
1999: Vihinen M; Kwan S P; Lester T; Ochs H D; Resnick I; Väliaho J; Conley M E; Smith C I
Mutations of the human BTK gene coding for bruton tyrosine kinase in X-linked agammaglobulinemia.
Human mutation 1999;13(4):280-5.
1998: Ollila J; Vihinen M
Stimulation of B and T cells activates expression of transcription and differentiation factors.
Biochemical and biophysical research communications 1998;249(2):475-80.
1998: Hansson H; Mattsson P T; Allard P; Haapaniemi P; Vihinen M; Smith C I; Hard T
Solution structure of the SH3 domain from Bruton's tyrosine kinase.
Biochemistry 1998;37(9):2912-24.
1998: Holinski-Feder E; Weiss M; Brandau O; Jedele K B; Nore B; Bäckesjö C M; Vihinen M; Hubbard S R; Belohradsky B H; Smith C I; Meindl A
Mutation screening of the BTK gene in 56 families with X-linked agammaglobulinemia (XLA): 47 unique mutations without correlation to clinical course.
Pediatrics 1998;101(2):276-84.
1998: Vihinen M; Smith C I
Interactions between SH2 and SH3 domains.
Biochemical and biophysical research communications 1998;242(2):351-6.
1998: Vihinen M; Brandau O; Brandén L J; Kwan S P; Lappalainen I; Lester T; Noordzij J G; Ochs H D; Ollila J; Pienaar S M; Riikonen P; Saha B K; Smith C I
BTKbase, mutation database for X-linked agammaglobulinemia (XLA).
Nucleic acids research 1998;26(1):242-7.
1998: Smith C I; Bäckesjö C M; Berglöf A; Brandén L J; Islam T; Mattsson P T; Mohamed A J; Müller S; Nore B; Vihinen M
X-linked agammaglobulinemia: lack of mature B lineage cells caused by mutations in the Btk kinase.
Springer seminars in immunopathology 1998;19(4):369-81.
1997: Lamminmäki U; Villoutreix B O; Jauria P; Saviranta P; Vihinen M; Nilsson L; Teleman O; Lövgren T
Structural analysis of an anti-estradiol antibody.
Molecular immunology 1997;34(16-17):1215-26.
1997: Vihinen M; Nore B F; Mattsson P T; Bäckesjö C M; Nars M; Koutaniemi S; Watanabe C; Lester T; Jones A; Ochs H D; Smith C I
Missense mutations affecting a conserved cysteine pair in the TH domain of Btk.
FEBS letters 1997;413(2):205-10.
1997: Saha B K; Curtis S K; Vogler L B; Vihinen M
Molecular and structural characterization of five novel mutations in the Bruton's tyrosine kinase gene from patients with X-linked agammaglobulinemia.
Molecular medicine (Cambridge, Mass.) 1997;3(7):477-85.
1997: Vihinen M; Mattsson P T; Smith C I
BTK, the tyrosine kinase affected in X-linked agammaglobulinemia.
Frontiers in bioscience : a journal and virtual library 1997;2():d27-42.
1997: Vihinen M; Belohradsky B H; Haire R N; Holinski-Feder E; Kwan S P; Lappalainen I; Lehväslaiho H; Lester T; Meindl A; Ochs H D; Ollila J; Vorechovsky I; Weiss M; Smith C I
BTKbase, mutation database for X-linked agammaglobulinemia (XLA)
Nucleic acids research 1997;25(1):166-71.
1997: Lappalainen I; Ollila J; Smith C I; Vihinen M
Registries of immunodeficiency patients and mutations.
Human mutation 1997;10(4):261-7.
1996: Smith C I; Vihinen M
Immunodeficiency mutation databases--a new research tool.
Immunology today 1996;17(11):495-6.
1996: Ollila J; Lappalainen I; Vihinen M
Sequence specificity in CpG mutation hotspots.
FEBS letters 1996;396(2-3):119-22.
1996: Mattsson P T; Vihinen M; Smith C I
X-linked agammaglobulinemia (XLA): a genetic tyrosine kinase (Btk) disease.
BioEssays : news and reviews in molecular, cellular and developmental biology 1996;18(10):825-34.
1996: Lamminmäki U; Vihinen M
Structural consequences of neopullulanase mutations.
Biochimica et biophysica acta 1996;1295(2):195-200.
1996: Vihinen M; Iwata T; Kinnon C; Kwan S P; Ochs H D; Vorechovský I; Smith C I
BTKbase, mutation database for X-linked agammaglobulinemia (XLA).
Nucleic acids research 1996;24(1):160-5.
1995: Vihinen M; Cooper M D; de Saint Basile G; Fischer A; Good R A; Hendriks R W; Kinnon C; Kwan S P; Litman G W; Notarangelo L D
BTKbase: a database of XLA-causing mutations. International Study Group.
Immunology today 1995;16(10):460-5.
1995: Maniar H S; Vihinen M; Webster A D; Nilsson L; Smith C I
Structural basis for X-linked agammaglobulinemia (XLA): mutations at interacting Btk residues R562, W563, and A582.
Clinical immunology and immunopathology 1995;76(3 Pt 2):S198-202.
1995: Boberg J; Salakoski T; Vihinen M
Accurate prediction of protein secondary structural class with fuzzy structural vectors.
Protein engineering 1995;8(6):505-12.
1995: Boberg J; Salakoski T; Vihinen M
Representative selection of proteins based on nuclear families.
Protein engineering 1995;8(5):501-3.
1995: Jin H; Webster A D; Vihinen M; Sideras P; Vorechovsky I; Hammarstróm L; Bernatowska-Matuszkiewicz E; Smith C I; Bobrow M; Vetrie D
Identification of Btk mutations in 20 unrelated patients with X-linked agammaglobulinaemia (XLA).
Human molecular genetics 1995;4(4):693-700.
1995: Vihinen M; Zvelebil M J; Zhu Q; Brooimans R A; Ochs H D; Zegers B J; Nilsson L; Waterfield M D; Smith C I
Structural basis for pleckstrin homology domain mutations in X-linked agammaglobulinemia.
Biochemistry 1995;34(5):1475-81.
1995: Vorechovský I; Vihinen M; de Saint Basile G; Honsová S; Hammarström L; Müller S; Nilsson L; Fischer A; Smith C I
DNA-based mutation analysis of Bruton's tyrosine kinase gene in patients with X-linked agammaglobulinaemia.
Human molecular genetics 1995;4(1):51-8.
1994: Vihinen M; Vetrie D; Maniar H S; Ochs H D; Zhu Q; Vorechovský I; Webster A D; Notarangelo L D; Nilsson L; Sowadski J M
Structural basis for chromosome X-linked agammaglobulinemia: a tyrosine kinase disease.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(26):12803-7.
1994: Vihinen M; Nilsson L; Smith C I
Structural basis of SH2 domain mutations in X-linked agammaglobulinemia.
Biochemical and biophysical research communications 1994;205(2):1270-7.
1994: Vihinen M
Modeling of prostate specific antigen and human glandular kallikrein structures.
Biochemical and biophysical research communications 1994;204(3):1251-6.
1994: Vihinen M; Peltonen T; Iitiä A; Suominen I; Mäntsälä P
C-terminal truncations of a thermostable Bacillus stearothermophilus alpha-amylase.
Protein engineering 1994;7(10):1255-9.
1994: Hakala J M; Vihinen M
Modelling the structure of the calcitonin gene-related peptide.
Protein engineering 1994;7(9):1069-75.
1994: Vihinen M; Nilsson L; Smith C I
Tec homology (TH) adjacent to the PH domain.
FEBS letters 1994;350(2-3):263-5.
1994: Zhu Q; Zhang M; Rawlings D J; Vihinen M; Hagemann T; Saffran D C; Kwan S P; Nilsson L; Smith C I; Witte O N; Chen S H; Ochs H D
Deletion within the Src homology domain 3 of Bruton's tyrosine kinase resulting in X-linked agammaglobulinemia (XLA).
The Journal of experimental medicine 1994;180(2):461-70.
1994: Vihinen M; Torkkila E; Riikonen P
Accuracy of protein flexibility predictions.
Proteins 1994;19(2):141-9.
1993: Vihinen M; Torkkila E
HYDRO: a program for protein hydropathy predictions.
Computer methods and programs in biomedicine 1993;41(2):121-9.
1992: Boberg J; Salakoski T; Vihinen M
Selection of a representative set of structures from Brookhaven Protein Data Bank.
Proteins 1992;14(2):265-76.
1992: Vihinen M; Lundin M; Baltscheffsky H
Computer modeling of two inorganic pyrophosphatases.
Biochemical and biophysical research communications 1992;186(1):122-8.
1992: Vihinen M; Euranto A; Luostarinen P; Nevalainen O
MULTICOMP: a program package for multiple sequence comparison.
Computer applications in the biosciences : CABIOS 1992;8(1):35-8.
1990: Vihinen M; Mäntsälä P
Characterization of a thermostable Bacillus stearothermophilus alpha-amylase.
Biotechnology and applied biochemistry 1990;12(4):427-35.
1990: Lahti R; Kolakowski L F; Heinonen J; Vihinen M; Pohjanoksa K; Cooperman B S
Conservation of functional residues between yeast and E. coli inorganic pyrophosphatases.
Biochimica et biophysica acta 1990;1038(3):338-45.
1990: Vihinen M; Ollikka P; Niskanen J; Meyer P; Suominen I; Karp M; Holm L; Knowles J; Mäntsälä P
Site-directed mutagenesis of a thermostable alpha-amylase from Bacillus stearothermophilus: putative role of three conserved residues.
Journal of biochemistry 1990;107(2):267-72.
1990: Vihinen M; Mäntsälä P
Conserved residues of liquefying alpha-amylases are concentrated in the vicinity of active site.
Biochemical and biophysical research communications 1990;166(1):61-5.
1989: Vihinen M; Mäntsälä P
Microbial amylolytic enzymes.
Critical reviews in biochemistry and molecular biology 1989;24(4):329-418.
1988: Vihinen M
An algorithm for simultaneous comparison of several sequences.
Computer applications in the biosciences : CABIOS 1988;4(1):89-92.
1987: Vihinen M
Relationship of protein flexibility to thermostability.
Protein engineering 1987;1(6):477-80.

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