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Jan Vijg

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Alexander Y Maslov; Wilber Quispe-Tintaya; Erwin Reiling; Bennett Van Houten; Harry van Steeg; Martijn E T Dollé; Shireen Ganapathi; Paul Hasty; Jan H J Hoeijmakers; Maaike Westerhof; Ryan R White; Jan Vijg
DNA damage in normally and prematurely aged mice.
Elena Beltrami; Rita Busuttil; Enrica Migliaccio; Pier Giuseppe Pelicci; Antonella Ruggiero; Jan Vijg; Marco Giorgio
Deletion of p66Shc in mice increases the frequency of size-change mutations in the lacZ transgene.
Jan Vijg; Yousin Suh
Genome instability and aging.

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All Publications

2013: Alexander Y Maslov; Wilber Quispe-Tintaya; Erwin Reiling; Bennett Van Houten; Harry van Steeg; Martijn E T Dollé; Shireen Ganapathi; Paul Hasty; Jan H J Hoeijmakers; Maaike Westerhof; Ryan R White; Jan Vijg
DNA damage in normally and prematurely aged mice.
Aging cell 2013;12(3):467-77.
2013: Elena Beltrami; Rita Busuttil; Enrica Migliaccio; Pier Giuseppe Pelicci; Antonella Ruggiero; Jan Vijg; Marco Giorgio
Deletion of p66Shc in mice increases the frequency of size-change mutations in the lacZ transgene.
Aging cell 2013;12(2):177-83.
2013: Jan Vijg; Yousin Suh
Genome instability and aging.
Annual review of physiology 2013;75():645-68.
2012: Francesca Faggioli; Jan Vijg; Tao Wang; Cristina Montagna
Chromosome-specific accumulation of aneuploidy in the aging mouse brain.
Human molecular genetics 2012;21(24):5246-53.
2012: Alexander Maslov; N Strogonova; Yousin Suh; C Tazearslan; A Bendebury; S Gravina; M Gundry; M Lee; Jan Vijg
5-aza-2'-deoxycytidine-induced genome rearrangements are mediated by DNMT1.
Oncogene 2012;31(50):5172-9.
2012: Tae Moon Kim; Jun Ho Ko; Cristina Montagna; Jan Vijg; Alexander J R Bishop; Lingchuan Hu; Sung-A Kim; Edward Hasty
RAD51 mutants cause replication defects and chromosomal instability.
Molecular and cellular biology 2012;32(18):3663-80.
2012: Vladimir N Anisimov; Andrzej Bartke; Nir Barzilai; Mikhail A Batin; Mikhail V Blagosklonny; Holly Brown-Borg; Yelena Budovskaya; Judith Campisi; Vadim Fraifeld; Claudio Franceschi; Bertrand Friguet; David Gems; Vadim Gladyshev; Vera Gorbunova; Andrei V Gudkov; Brian Kennedy; Maria Konovalenko; Brian Kraemer; Alexey Moskalev; Elena Pasyukova; Isabelle Petropoulos; Suresh Rattan; Blanka Rogina; Andrei Seluanov; MV Shaposhnikov; Robert Shmookler Reis; Nektarios Tavernarakis; Jan Vijg; Anatoli Yashin; Piotr Zimniak
The second international conference "genetics of aging and longevity".
Aging 2012;4(5):305-17.
2012: Michael Gundry; Wenge Li; Shahina Maqbool; Jan Vijg
Direct, genome-wide assessment of DNA mutations in single cells.
Nucleic acids research 2012;40(5):2032-40.
2012: Michael Gundry; Jan Vijg
Direct mutation analysis by high-throughput sequencing: from germline to low-abundant, somatic variants.
Mutation research 2012;729(1-2):1-15.
2012: Saurabh Gombar; Jan H J Hoeijmakers; Hwa Jin Jung; Joris Pothof; Gil Atzmon; Nir Barzilai; Brent Calder; Judith Campisi; Feng Dong; Xiao-Li Tian; Jan Vijg; Yousin Suh
Comprehensive microRNA profiling in B-cells of human centenarians by massively parallel sequencing.
BMC genomics 2012;13():353.
2012: Wenge Li; Jan Vijg
Measuring genome instability in aging - a mini-review.
Gerontology 2012;58(2):129-38.
2011: Francesca Faggioli; Jan Vijg; Cristina Montagna
Chromosomal aneuploidy in the aging brain.
Mechanisms of ageing and development 2011;132(8-9):429-36.
2011: Martijn E T Dollé; Paul Hasty; Jan H J Hoeijmakers; Raoul V Kuiper; Laura J Niedernhofer; Joke Robinson; Marianne Roodbergen; Ingrid van der Pluijm; Rudolf B Beems; Liset de la Fonteyne; Sisca de Vlugt; Piet de With; Jan Vijg; Susan W P Wijnhoven; Harry van Steeg
Broad segmental progeroid changes in short-lived Ercc1(-/Δ7) mice.
Pathobiology of aging & age related diseases 2011;1():.
2011: Ana Maria Garcia; MoonSook Lee; Justine Liepkalns; Martha Lundell; Robert N Salomon; Jan Vijg; Alice Witsell; R Brent Calder; Mitch McVey
Loss of the bloom syndrome helicase increases DNA ligase 4-independent genome rearrangements and tumorigenesis in aging Drosophila.
Genome biology 2011;12(12):R121.
2010: Jan Vijg
Interview with Jan Vijg, Ph.D. [Interviewed by Vicki Glaser].
Rejuvenation research 2010;13(5):619-22.
2010: Yousin Suh; Jan Vijg
The long and short of fertility and longevity.
Cell metabolism 2010;12(3):209-10.
2010: Michael Rae; Robert N Butler; Judith Campisi; Aubrey D N J de Grey; Caleb E Finch; Michael Gough; George M Martin; Jan Vijg; Kevin M Perrott; Barbara J Logan
The demographic and biomedical case for late-life interventions in aging.
Science translational medicine 2010;2(40):40cm21.
2010: Ana Maria Garcia; R Brent Calder; Martijn E T Dollé; Martha Lundell; pankaj kapahi; Jan Vijg
Age- and temperature-dependent somatic mutation accumulation in Drosophila melanogaster.
PLoS genetics 2010;6(5):e1000950.
2010: Mikhail V Blagosklonny; Judy Campisi; David A Sinclair; Andrzej Bartke; Maria A Blasco; William M Bonner; Vilhelm A Bohr; Robert M Brosh; Anne Brunet; Ronald A Depinho; Lawrence A Donehower; Caleb E Finch; TOREN FINKEL; Myriam Gorospe; Andrei V Gudkov; Michael N Hall; Siegfried Hekimi; Stephen L Helfand; Jan Karlseder; Cynthia Kenyon; Guido Kroemer; Valter Longo; Andre Nussenzweig; Heinz D Osiewacz; Daniel S Peeper; Thomas A Rando; K Lenhard Rudolph; Paolo Sassone-Corsi; Manuel Serrano; Norman E Sharpless; Vladimir P Skulachev; Jonathan L Tilly; John Tower; Eric Verdin; Jan Vijg
Impact papers on aging in 2009.
Aging 2010;2(3):111-21.
2010: Silvia Gravina; Jan Vijg
Epigenetic factors in aging and longevity.
Pflügers Archiv : European journal of physiology 2010;459(2):247-58.
2009: pankaj kapahi; Jan Vijg
Aging--lost in translation?
The New England journal of medicine 2009;361(27):2669-70.
2009: Alexander Maslov; Maya Metrikin; Jan Vijg
A dual-activation, adenoviral-based system for the controlled induction of DNA double-strand breaks by the restriction endonuclease SacI.
BioTechniques 2009;47(4):847-54.
2009: Alexander Maslov; Jan Vijg
Genome instability, cancer and aging.
Biochimica et biophysica acta 2009;1790(10):963-9.
2009: Ursula Edman; Ana Maria Garcia; Rita A Busuttil; Dylan Sorensen; Martha Lundell; pankaj kapahi; Jan Vijg
Lifespan extension by dietary restriction is not linked to protection against somatic DNA damage in Drosophila melanogaster.
Aging cell 2009;8(3):331-8.
2009: Jan Vijg
SNP'ing for longevity.
Aging 2009;1(5):442-3.
2009: Judith Campisi; Jan Vijg
Does damage to DNA and other macromolecules play a role in aging? If so, how?
The journals of gerontology. Series A, Biological sciences and medical sciences 2009;64(2):175-8.
2009: Konstantin Khrapko; Jan Vijg
Mitochondrial DNA mutations and aging: devils in the details?
Trends in genetics : TIG 2009;25(2):91-8.
2009: Viviana Perez; Holly Van Remmen; Alex Bokov; Charles J Epstein; Jan Vijg; Arlan G Richardson
The overexpression of major antioxidant enzymes does not extend the lifespan of mice.
Aging cell 2009;8(1):73-5.
2008: Guliang Wang; Steve Carbajal; Jan Vijg; John DiGiovanni; Karen M Vasquez
DNA structure-induced genomic instability in vivo.
Journal of the National Cancer Institute 2008;100(24):1815-7.
2008: Jan Vijg; Alexander Maslov; Yousin Suh
Aging: a sirtuin shake-up?
Cell 2008;135(5):797-8.
2008: Valerie B Holcomb; Francis Rodier; YongJun Choi; Rita A Busuttil; Hannes Vogel; Jan Vijg; Judith Campisi; Edward Hasty
Ku80 deletion suppresses spontaneous tumors and induces a p53-mediated DNA damage response.
Cancer research 2008;68(22):9497-502.
2008: George A Garinis; Gijsbertus T J van der Horst; Jan Vijg; Jan H J Hoeijmakers
DNA damage and ageing: new-age ideas for an age-old problem.
Nature cell biology 2008;10(11):1241-7.
2008: Valter D Longo; Michael R Lieber; Jan Vijg
Turning anti-ageing genes against cancer.
Nature reviews. Molecular cell biology 2008;9(11):903-10.
2008: Ana Maria Garcia; Rita A Busuttil; R Brent Calder; Martijn E T Dollé; Vivian Diaz; C Alex McMahan; Andrzej Bartke; James Nelson; Robert L Reddick; Jan Vijg
Effect of Ames dwarfism and caloric restriction on spontaneous DNA mutation frequency in different mouse tissues.
Mechanisms of ageing and development 2008;129(9):528-33.
2008: Jan Vijg; Judith Campisi
Puzzles, promises and a cure for ageing.
Nature 2008;454(7208):1065-71.
2008: Rika Ouchida; Akiko Ukai; Hiromi Mori; Kiyoko Kawamura; Martijn E T Dollé; Masatoshi Tagawa; Akemi Sakamoto; Takeshi Tokuhisa; Tadashi Yokosuka; Takashi Saito; Masayuki Yokoi; Fumio Hanaoka; Jan Vijg; Ji-Yang Wang
Genetic analysis reveals an intrinsic property of the germinal center B cells to generate A:T mutations.
DNA repair 2008;7(8):1392-8.
2008: Jan Vijg
The role of DNA damage and repair in aging: new approaches to an old problem.
Mechanisms of ageing and development 2008;129(7-8):498-502.
2008: Rita A Busuttil; Qingcong Lin; Peter J Stambrook; Raju Kucherlapati; Jan Vijg
Mutation frequencies and spectra in DNA polymerase eta-deficient mice.
Cancer research 2008;68(7):2081-4.
2008: Joost P M Melis; Susan W P Wijnhoven; Rudolf B Beems; Marianne Roodbergen; Jolanda van den Berg; Hojin Moon; Errol Friedberg; Gijsbertus T J van der Horst; Jan H J Hoeijmakers; Jan Vijg; Harry van Steeg
Mouse models for xeroderma pigmentosum group A and group C show divergent cancer phenotypes.
Cancer research 2008;68(5):1347-53.
2008: Rita A Busuttil; Denise P Muñoz; Ana Maria Garcia; Francis Rodier; Woo Ho Kim; Yousin Suh; Edward Hasty; Judith Campisi; Jan Vijg
Effect of Ku80 deficiency on mutation frequencies and spectra at a LacZ reporter locus in mouse tissues and cells.
PloS one 2008;3(10):e3458.
2008: Jung Yoon Park; Mi-Ook Cho; Shanique Leonard; Brent Calder; I Saira Mian; Woo Ho Kim; Susan Wijnhoven; Harry van Steeg; James Mitchell; Gijsbertus T J van der Horst; Jan Hoeijmakers; Pinchas Cohen; Jan Vijg; Yousin Suh
Homeostatic imbalance between apoptosis and cell renewal in the liver of premature aging Xpd mice.
PloS one 2008;3(6):e2346.
2007: Jan Vijg; Martijn E T Dollé
Genome instability: cancer or aging?
Mechanisms of ageing and development 2007;128(7-8):466-8.
2007: Ana Maria Garcia; Anastasia Derventzi; Rita Busuttil; R Brent Calder; Ernesto Perez; Linda Chadwell; Martijn E T Dollé; Martha Lundell; Jan Vijg
A model system for analyzing somatic mutations in Drosophila melanogaster.
Nature methods 2007;4(5):401-3.
2007: Rita A Busuttil; Rumana Bahar; Jan Vijg
Genome dynamics and transcriptional deregulation in aging.
Neuroscience 2007;145(4):1341-7.
2007: Konstantin Khrapko; Jan Vijg
Mitochondrial DNA mutations and aging: a case closed?
Nature genetics 2007;39(4):445-6.
2007: Rita A Busuttil; Ana Maria Garcia; Robert L Reddick; Martijn E T Dollé; R Brent Calder; James Nelson; Jan Vijg
Intra-organ variation in age-related mutation accumulation in the mouse.
PloS one 2007;2(9):e876.
2007: Ana Maria Garcia; Rita A Busuttil; Armando Rodriguez; Carlos Cabrera; Martha Lundell; Martijn E T Dollé; Jan Vijg
Detection and analysis of somatic mutations at a lacZ reporter locus in higher organisms: application to Mus musculus and Drosophila melanogaster.
Methods in molecular biology (Clifton, N.J.) 2007;371():267-87.
2007: R Brent Calder; Rudolf B Beems; Harry van Steeg; I Saira Mian; Paul H M Lohman; Jan Vijg
MPHASYS: a mouse phenotype analysis system.
BMC bioinformatics 2007;8():183.
2006: Laura J Niedernhofer; george garinis; Anja Raams; Astrid S Lalai; Andria Rasile Robinson; Esther Appeldoorn; Hanny Odijk; Roos Oostendorp; Anwaar Ahmad; Wibeke J van Leeuwen; Arjan F Theil; Wim Vermeulen; Gijsbertus T J van der Horst; Peter Meinecke; Wim J Kleijer; Jan Vijg; Nicolaas G J Jaspers; Jan H J Hoeijmakers
A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axis.
Nature 2006;444(7122):1038-43.
2006: Diane C Cabelof; Yuji Ikeno; Abraham Nyska; Rita A Busuttil; Njwen Anyangwe; Jan Vijg; Larry H Matherly; James Tucker; Samuel H Wilson; Arlan G Richardson; Ahmad R Heydari
Haploinsufficiency in DNA polymerase beta increases cancer risk with age and alters mortality rate.
Cancer research 2006;66(15):7460-5.
2006: Rumana Bahar; Claudia H Hartmann; Karl A Rodriguez; Ashley D Denny; Rita A Busuttil; Martijn E T Dollé; R Brent Calder; Gary B Chisholm; Bradley Pollock; Christoph A Klein; Jan Vijg
Increased cell-to-cell variation in gene expression in ageing mouse heart.
Nature 2006;441(7096):1011-4.
2006: Konstantin Khrapko; Yevgenya Kraytsberg; Aubrey D N J de Grey; Jan Vijg; Eric A Schon
Does premature aging of the mtDNA mutator mouse prove that mtDNA mutations are involved in natural aging?
Aging cell 2006;5(3):279-82.
2006: TOREN FINKEL; Jan Vijg; Jerry W Shay
Time, tumours and telomeres. Meeting on Cancer and Aging.
EMBO reports 2006;7(5):479-83.
2006: Jan Vijg; Yousin Suh
Ageing: chromatin unbound.
Nature 2006;440(7086):874-5.
2006: Martijn E T Dollé; Rita A Busuttil; Ana Maria Garcia; Susan W P Wijnhoven; Ellen van Drunen; Laura J Niedernhofer; Gijsbertus T J van der Horst; Jan H J Hoeijmakers; Harry van Steeg; Jan Vijg
Increased genomic instability is not a prerequisite for shortened lifespan in DNA repair deficient mice.
Mutation research 2006;596(1-2):22-35.
2006: James Mele; Holly Van Remmen; Jan Vijg; Arlan G Richardson
Characterization of transgenic mice that overexpress both copper zinc superoxide dismutase and catalase.
Antioxidants & redox signaling 2006;8(3-4):628-38.
2006: Yousin Suh; Jan Vijg
Maintaining genetic integrity in aging: a zero sum game.
Antioxidants & redox signaling 2006;8(3-4):559-71.
2006: Rita A Busuttil; Miguel Rubio; Martijn E T Dollé; Judith Campisi; Jan Vijg
Mutant frequencies and spectra depend on growth state and passage number in cells cultured from transgenic lacZ-plasmid reporter mice.
DNA repair 2006;5(1):52-60.
2005: Rita A Busuttil; Ana Maria Garcia; Carlos Cabrera; Armando Rodriguez; Yousin Suh; Woo Ho Kim; Ting-Ting Huang; Jan Vijg
Organ-specific increase in mutation accumulation and apoptosis rate in CuZn-superoxide dismutase-deficient mice.
Cancer research 2005;65(24):11271-5.
2005: Jan Vijg; Rita A Busuttil; Rumana Bahar; Martijn E T Dollé
Aging and genome maintenance.
Annals of the New York Academy of Sciences 2005;1055():35-47.
2005: Jan Vijg; Edward Hasty
Aging and p53: getting it straight. A commentary on a recent paper by Gentry and Venkatachalam.
Aging cell 2005;4(6):331-3.
2005: Susan W P Wijnhoven; Rudolf B Beems; Marianne Roodbergen; Jolanda van den Berg; Paul H M Lohman; Karin Diderich; Gijsbertus T J van der Horst; Jan Vijg; Jan H J Hoeijmakers; Harry van Steeg
Accelerated aging pathology in ad libitum fed Xpd(TTD) mice is accompanied by features suggestive of caloric restriction.
DNA repair 2005;4(11):1314-24.
2005: Yousin Suh; Jan Vijg
SNP discovery in associating genetic variation with human disease phenotypes.
Mutation research 2005;573(1-2):41-53.
2005: Mark T McCammon; John S Gillette; Derek P Thomas; Srinivas V Ramaswamy; Ishmael I Rosas; Edward Graviss; Jan Vijg; Teresa N Quitugua
Detection by denaturing gradient gel electrophoresis of pncA mutations associated with pyrazinamide resistance in Mycobacterium tuberculosis isolates from the United States-Mexico border region.
Antimicrobial agents and chemotherapy 2005;49(6):2210-7.
2005: Mark T McCammon; John S Gillette; Derek P Thomas; Srinivas V Ramaswamy; Edward Graviss; Barry N Kreiswirth; Jan Vijg; Teresa N Quitugua
Detection of rpoB mutations associated with rifampin resistance in Mycobacterium tuberculosis using denaturing gradient gel electrophoresis.
Antimicrobial agents and chemotherapy 2005;49(6):2200-9.
2005: Armand M Leroi; Andrzej Bartke; Giovanna De Benedictis; Claudio Franceschi; Anton Gartner; Efstathios S Gonos; Eleftherios Gonos; Martin E Fedei; Martin E Feder; Toomas Kivisild; Sylvia Lee; Nesrin Kartaf-Ozer; Nesrin Kartal-Ozer; Michael Schumacher; Ewa Sikora; Eline Slagboom; Mark Tatar; Anatoliy Yashin; Jan Vijg; Bas Zwaan
What evidence is there for the existence of individual genes with antagonistic pleiotropic effects?
Mechanisms of ageing and development 2005;126(3):421-9.
2005: Jan Vijg; Yousin Suh
Genetics of longevity and aging.
Annual review of medicine 2005;56():193-212.
2004: Jan Vijg
Impact of genome instability on transcription regulation of aging and senescence.
Mechanisms of ageing and development 2004;125(10-11):747-53.
2004: Jan Vijg; R Brent Calder
Transcripts of aging.
Trends in genetics : TIG 2004;20(6):221-4.
2004: Edward Hasty; Jan Vijg
Rebuttal to Miller: 'Accelerated aging': a primrose path to insight?'.
Aging cell 2004;3(2):67-9.
2004: Edward Hasty; Jan Vijg
Accelerating aging by mouse reverse genetics: a rational approach to understanding longevity.
Aging cell 2004;3(2):55-65.
2004: Xinlian Chen; Hanyu Liang; Holly Van Remmen; Jan Vijg; Arlan G Richardson
Catalase transgenic mice: characterization and sensitivity to oxidative stress.
Archives of biochemistry and biophysics 2004;422(2):197-210.
2003: Rita A Busuttil; Miguel Rubio; Martijn E T Dollé; Judith Campisi; Jan Vijg
Oxygen accelerates the accumulation of mutations during the senescence and immortalization of murine cells in culture.
Aging cell 2003;2(6):287-94.
2003: Hong Yang; MingJian Shi; Arlan G Richardson; Jan Vijg; ZhongMao Guo
Attenuation of leukocyte-endothelium interaction by antioxidant enzymes.
Free radical biology & medicine 2003;35(3):266-76.
2003: M Bounpheng; S McGrath; D Macias; Nathalie J van Orsouw; Yousin Suh; D Rines; Jan Vijg
Rapid, inexpensive scanning for all possible BRCA1 and BRCA2 gene sequence variants in a single assay: implications for genetic testing.
Journal of medical genetics 2003;40(4):e33.
2003: Esther M Hoogervorst; Annemieke de Vries; Rudolf B Beems; Conny Th M van Oostrom; Piet W Wester; Joseph G Vos; Wendy Bruins; Marianne Roodbergen; Flemming R Cassee; Jan Vijg; Frederik J Van Schooten; Harry van Steeg
Combined oral benzo[a]pyrene and inhalatory ozone exposure have no effect on lung tumor development in DNA repair-deficient Xpa mice.
Carcinogenesis 2003;24(3):613-9.
2003: Edward Hasty; Judith Campisi; Jan H J Hoeijmakers; Harry van Steeg; Jan Vijg
Aging and genome maintenance: lessons from the mouse?
Science (New York, N.Y.) 2003;299(5611):1355-9.
2003: Xinlian Chen; James Mele; Heidi Giese; Holly Van Remmen; Martijn E T Dollé; Mark Steinhelper; Arlan G Richardson; Jan Vijg
A strategy for the ubiquitous overexpression of human catalase and CuZn superoxide dismutase genes in transgenic mice.
Mechanisms of ageing and development 2003;124(2):219-27.
2003: Jan Vijg; Yousin Suh
Functional genomics of ageing.
Mechanisms of ageing and development 2003;124(1):3-8.
2003: Hong Yang; MingJian Shi; Holly Van Remmen; XinLian Chen; Jan Vijg; Arlan G Richardson; ZhongMao Guo
Reduction of pressor response to vasoconstrictor agents by overexpression of catalase in mice.
American journal of hypertension 2003;16(1):1-5.
2002: Martijn E T Dollé; Jan Vijg
Genome dynamics in aging mice.
Genome research 2002;12(11):1732-8.
2002: Irene L Andrulis; Hoda Anton-Culver; Jeanne Beck; Betsy Bove; Jeff Boyd; Saundra S Buys; Andrew K Godwin; John L Hopper; Frederick P Li; Susan L Neuhausen; Hilmi Ozcelik; David Peel; Regina M Santella; Melissa C Southey; Nathalie J van Orsouw; Deon J Venter; Jan Vijg; Alice S Whittemore
Comparison of DNA- and RNA-based methods for detection of truncating BRCA1 mutations.
Human mutation 2002;20(1):65-73.
2002: Edward Hasty; Jan Vijg
Aging. Genomic priorities in aging.
Science (New York, N.Y.) 2002;296(5571):1250-1.
2002: Jan Vijg; Martijn E T Dollé
Large genome rearrangements as a primary cause of aging.
Mechanisms of ageing and development 2002;123(8):907-15.
2002: Ekaterina Nekhaeva; Natalya Bodyak; Yevgenya Kraytsberg; Sean B McGrath; Nathalie J van Orsouw; Anna Pluzhnikov; Jeanne Y Wei; Jan Vijg; Konstantin Khrapko
Clonally expanded mtDNA point mutations are abundant in individual cells of human tissues.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(8):5521-6.
2002: Jan Vijg
On key lesions and all that: a tribute to Paul Lohman.
Mutation research 2002;499(2):121-34.
2002: Heidi Giese; Wendy K Snyder; Conny Th M van Oostrom; Harry van Steeg; Martijn E T Dollé; Jan Vijg
Age-related mutation accumulation at a lacZ reporter locus in normal and tumor tissues of Trp53-deficient mice.
Mutation research 2002;514(1-2):153-63.
2002: Martijn E T Dollé; Wendy K Snyder; David B Dunson; Jan Vijg
Mutational fingerprints of aging.
Nucleic acids research 2002;30(2):545-9.
2002: Yousin Suh; Kang-Ae Lee; Woo Ho Kim; Bok Ghee Han; Jan Vijg; Sang Chul Park
Aging alters the apoptotic response to genotoxic stress.
Nature medicine 2002;8(1):3-4.
2002: Jan Vijg; Nathalie J van Orsouw
Searching for genetic determinants of human aging and longevity: opportunities and challenges.
Mechanisms of ageing and development 2002;123(2-3):195-205.
2001: Charis Eng; Lawrence C Brody; Teresa M U Wagner; Peter Devilee; Jan Vijg; Csilla I Szabo; Sean V Tavtigian; Katherine L Nathanson; Elaine A Ostrander; Thomas S Frank
Interpreting epidemiological research: blinded comparison of methods used to estimate the prevalence of inherited mutations in BRCA1.
Journal of medical genetics 2001;38(12):824-33.
2001: S B McGrath; M Bounpheng; L Torres; M Calavetta; C B Scott; Yousin Suh; D Rines; Nathalie J van Orsouw; Jan Vijg
High-speed, multicolor fluorescent two-dimensional gene scanning.
Genomics 2001;78(1-2):83-90.
2001: Martijn E T Dollé; WK Snyder; Jan Vijg
Genotyping the Prop-1 mutation in Ames dwarf mice.
Mechanisms of ageing and development 2001;122(15):1915-8.
2001: Sandra L Martin; C L Hopkins; A Naumer; Martijn E T Dollé; Jan Vijg
Mutation frequency and type during ageing in mouse seminiferous tubules.
Mechanisms of ageing and development 2001;122(12):1321-31.
2001: Z Guo; Holly Van Remmen; Hong Yang; Xinlian Chen; James Mele; Jan Vijg; C J Epstein; Ye-Shih Ho; Arlan G Richardson
Changes in expression of antioxidant enzymes affect cell-mediated LDL oxidation and oxidized LDL-induced apoptosis in mouse aortic cells.
Arteriosclerosis, thrombosis, and vascular biology 2001;21(7):1131-8.
2001: Jan Vijg; Thomas T Perls; C Franceschi; Nathalie J van Orsouw
BRCA1 gene sequence variation in centenarians.
Annals of the New York Academy of Sciences 2001;928():85-96.
2000: Samuel E Schriner; Charles E Ogburn; A C Smith; TG Newcomb; Warren C Ladiges; Martijn E T Dollé; Jan Vijg; Ken-Ichiro Fukuchi; George M Martin
Levels of DNA damage are unaltered in mice overexpressing human catalase in nuclei.
Free radical biology & medicine 2000;29(7):664-73.
2000: Martijn E T Dollé; WK Snyder; J A Gossen; P H Lohman; Jan Vijg
Distinct spectra of somatic mutations accumulated with age in mouse heart and small intestine.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(15):8403-8.
2000: Harry van Steeg; L H Mullenders; Jan Vijg
Mutagenesis and carcinogenesis in nucleotide excision repair-deficient XPA knock out mice.
Mutation research 2000;450(1-2):167-80.
2000: JJ Yeh; Kathryn L Lunetta; Nathalie J van Orsouw; F D Moore; George L Mutter; Jan Vijg; Patricia Dahia; Charis Eng
Somatic mitochondrial DNA (mtDNA) mutations in papillary thyroid carcinomas and differential mtDNA sequence variants in cases with thyroid tumours.
Oncogene 2000;19(16):2060-6.
2000: Jan Vijg
The science of aging and the need for a mechanistic approach.
Mechanisms of ageing and development 2000;114(1):1-3.
2000: Jan Vijg
Somatic mutations and aging: a re-evaluation.
Mutation research 2000;447(1):117-35.
2000: Martijn E T Dollé; Heidi Giese; H van Steeg; Jan Vijg
Mutation accumulation in vivo and the importance of genome stability in aging and cancer.
Results and problems in cell differentiation 2000;29():165-80.
1999: Jan Vijg
Profiling aging by gene arrays.
Mechanisms of ageing and development 1999;112(1):1-4.
1999: Nathalie J van Orsouw; RK Dhanda; Y Elhaji; steven narod; Frederick P Li; Charis Eng; Jan Vijg
A highly accurate, low cost test for BRCA1 mutations.
Journal of medical genetics 1999;36(10):747-53.
1999: Jan Vijg; Nathalie J van Orsouw
Two-dimensional gene scanning: exploring human genetic variability.
Electrophoresis 1999;20(6):1239-49.
1999: Konstantin Khrapko; Natalya Bodyak; William G Thilly; Nathalie J van Orsouw; X Zhang; Hilary A Coller; Thomas T Perls; M Upton; Jan Vijg; Jeanne Y Wei
Cell-by-cell scanning of whole mitochondrial genomes in aged human heart reveals a significant fraction of myocytes with clonally expanded deletions.
Nucleic acids research 1999;27(11):2434-41.
1999: Martijn E T Dollé; Hans-Joerg Martus; M Novak; Nathalie J van Orsouw; Jan Vijg
Characterization of color mutants in lacZ plasmid-based transgenic mice, as detected by positive selection.
Mutagenesis 1999;14(3):287-93.
1999: Heidi Giese; Martijn E T Dollé; A Hezel; Harry van Steeg; Jan Vijg
Accelerated accumulation of somatic mutations in mice deficient in the nucleotide excision repair gene XPA.
Oncogene 1999;18(5):1257-60.
1999: Nathalie J van Orsouw; Jan Vijg
Design and application of 2-D DGGE-based gene mutational scanning tests.
Genetic analysis : biomolecular engineering 1999;14(5-6):205-13.
1999: Jan Vijg
Genetics of aging. Sponsored by Cold Spring Harbor Laboratory, 2-5 April 1998.
Biochimica et biophysica acta 1999;1423(1):R1-12.
1999: Conny Th M van Oostrom; M Boeve; Jolanda van den Berg; Annemieke de Vries; Martijn E T Dollé; Rudolf B Beems; Coen F van Kreijl; Jan Vijg; Harry van Steeg
Effect of heterozygous loss of p53 on benzo[a]pyrene-induced mutations and tumors in DNA repair-deficient XPA mice.
Environmental and molecular mutagenesis 1999;34(2-3):124-30.
1999: Martijn E T Dollé; WK Snyder; Nathalie J van Orsouw; Jan Vijg
Background mutations and polymorphisms in lacZ-plasmid transgenic mice.
Environmental and molecular mutagenesis 1999;34(2-3):112-20.
1998: Sandra L Dabora; I Sigalas; F Hall; Charis Eng; Jan Vijg; David J Kwiatkowski
Comprehensive mutation analysis of TSC1 using two-dimensional DNA electrophoresis with DGGE.
Annals of human genetics 1998;62(Pt 6):491-504.
1998: RK Dhanda; Nathalie J van Orsouw; I Sigalas; Charis Eng; Jan Vijg
Critical factors in the performance and cost of two-dimensional gene scanning: RB1 as a model.
BioTechniques 1998;25(4):664-8, 670, 672-5.
1998: Nathalie J van Orsouw; X Zhang; Jeanne Y Wei; D R Johns; Jan Vijg
Mutational scanning of mitochondrial DNA by two-dimensional electrophoresis.
Genomics 1998;52(1):27-36.
1998: R D Rines; Nathalie J van Orsouw; I Sigalas; Frederick P Li; Charis Eng; Jan Vijg
Comprehensive mutational scanning of the p53 coding region by two-dimensional gene scanning.
Carcinogenesis 1998;19(6):979-84.
1998: Jan Vijg; H van Steeg
Transgenic assays for mutations and cancer: current status and future perspectives.
Mutation research 1998;400(1-2):337-54.
1998: T T Perls; E Bubrick; C G Wager; Jan Vijg; L Kruglyak
Siblings of centenarians live longer.
Lancet 1998;351(9115):1560.
1998: Nathalie J van Orsouw; RK Dhanda; R D Rines; W M Smith; I Sigalas; Charis Eng; Jan Vijg
Rapid design of denaturing gradient-based two-dimensional electrophoretic gene mutational scanning tests.
Nucleic acids research 1998;26(10):2398-406.
1998: RK Dhanda; W M Smith; C B Scott; Charis Eng; Jan Vijg
A simple system for automated two-dimensional electrophoresis: applications to genetic testing.
Genetic testing 1998;2(1):67-70.
1998: W M Smith; Nathalie J van Orsouw; Edward A Fox; Richard D Kolodner; Jan Vijg; Charis Eng
Accurate, high-throughput "snapshot" detection of hMLH1 mutations by two-dimensional DNA electrophoresis.
Genetic testing 1998;2(1):43-53.
1997: Jan Vijg; Martijn E T Dollé; Hans-Joerg Martus; ME Boerrigter
Transgenic mouse models for studying mutations in vivo: applications in aging research.
Mechanisms of ageing and development 1997;99(3):257-71.
1997: Annemieke de Vries; Martijn E T Dollé; J L Broekhof; J J Muller; ED Kroese; Coen F van Kreijl; PJ Capel; Jan Vijg; Harry van Steeg
Induction of DNA adducts and mutations in spleen, liver and lung of XPA-deficient/lacZ transgenic mice after oral treatment with benzo[a]pyrene: correlation with tumour development.
Carcinogenesis 1997;18(12):2327-32.
1997: Martijn E T Dollé; Heidi Giese; C L Hopkins; Hans-Joerg Martus; J M Hausdorff; Jan Vijg
Rapid accumulation of genome rearrangements in liver but not in brain of old mice.
Nature genetics 1997;17(4):431-4.
1997: Jan Vijg; Martijn E T Dollé; Hans-Joerg Martus; ME Boerrigter
Transgenic mouse models for studying mutations in vivo: applications in aging research.
Mechanisms of ageing and development 1997;98(3):189-202.
1997: Deborah J Marsh; S Roth; Kathryn L Lunetta; Akseli Hemminki; Patricia Dahia; Pertti Sistonen; Z Zheng; S Caron; Nathalie J van Orsouw; Walter F Bodmer; SE Cottrell; Malcolm G Dunlop; Diana Eccles; Shirley V Hodgson; Heikki Järvinen; Ilmo Kellokumpu; D Markie; Kay Neale; Robin Phillips; P Rozen; Sapna Syngal; Jan Vijg; Ian P M Tomlinson; Lauri A Aaltonen; Charis Eng
Exclusion of PTEN and 10q22-24 as the susceptibility locus for juvenile polyposis syndrome.
Cancer research 1997;57(22):5017-21.
1997: Charis Eng; Jan Vijg
Genetic testing: the problems and the promise.
Nature biotechnology 1997;15(5):422-6.
1997: Nathalie J van Orsouw; D Li; Jan Vijg
Denaturing gradient gel electrophoresis (DGGE) increases resolution and informativity of Alu-directed inter-repeat PCR.
Molecular and cellular probes 1997;11(2):95-101.
1997: Anders D Børglum; Mette Nyegaard; A B Kvistgaard; E Mullaart; A G Uitterlinden; Jan Vijg; Torben A Kruse
Mapping of 34 minisatellite loci resolved by two-dimensional DNA typing.
Cytogenetics and cell genetics 1997;79(3-4):248-56.
1997: ME Boerrigter; Jan Vijg
Sources of variability in mutant frequency determinations in different organs of lacZ plasmid-based transgenic mice: experimental features and statistical analysis.
Environmental and molecular mutagenesis 1997;29(3):221-9.
1996: N J Van Orsouw; D Li; Pieter van der Vlies; Hans Scheffer; Charis Eng; Charles H C M Buys; Frederick P Li; Jan Vijg
Mutational scanning of large genes by extensive PCR multiplexing and two-dimensional electrophoresis: application to the RB1 gene.
Human molecular genetics 1996;5(6):755-61.
1996: D Li; Jan Vijg
Multiplex co-amplification of 24 retinoblastoma gene exons after pre-amplification by long-distance PCR.
Nucleic acids research 1996;24(3):538-9.
1996: Y Wu; Robert M W Hofstra; Hans Scheffer; André G Uitterlinden; E Mullaart; Charles H C M Buys; Jan Vijg
Comprehensive and accurate mutation scanning of the CFTR gene by two-dimensional DNA electrophoresis.
Human mutation 1996;8(2):160-7.
1996: Martijn E T Dollé; Hans-Joerg Martus; J A Gossen; ME Boerrigter; Jan Vijg
Evaluation of a plasmid-based transgenic mouse model for detecting in vivo mutations.
Mutagenesis 1996;11(1):111-8.
1995: Jan Vijg
Two-dimensional DNA typing: A cost-effective way of analyzing complex mixtures of DNA fragments for sequence variations.
Molecular biotechnology 1995;4(3):275-95.
1995: ME Boerrigter; Martijn E T Dollé; Hans-Joerg Martus; J A Gossen; Jan Vijg
Plasmid-based transgenic mouse model for studying in vivo mutations.
Nature 1995;377(6550):657-9.
1995: E Mullaart; A M Verwest; Anders D Børglum; André G Uitterlinden; Gerard te Meerman; Torben A Kruse; Jan Vijg
Two-dimensional DNA typing of human pedigrees: spot pattern characterization and segregation.
Genomics 1995;29(3):641-6.
1995: Hans-Joerg Martus; Martijn E T Dollé; J A Gossen; ME Boerrigter; Jan Vijg
Use of transgenic mouse models for studying somatic mutations in aging.
Mutation research 1995;338(1-6):203-13.
1995: J A Gossen; Hans-Joerg Martus; J Y Wei; Jan Vijg
Spontaneous and X-ray-induced deletion mutations in a LacZ plasmid-based transgenic mouse model.
Mutation research 1995;331(1):89-97.
1995: S Xio; D Li; Jan Vijg; D J Sugarbaker; J M Corson; J A Fletcher
Codeletion of p15 and p16 in primary malignant mesothelioma.
Oncogene 1995;11(3):511-5.
1995: ME Boerrigter; Jeanne Y Wei; Jan Vijg
Induction and repair of benzo[a]pyrene-DNA adducts in C57BL/6 and BALB/c mice: association with aging and longevity.
Mechanisms of ageing and development 1995;82(1):31-50.
1995: Sheng Xiao; D Li; J M Corson; Jan Vijg; Jonathan A Fletcher
Codeletion of p15 and p16 genes in primary non-small cell lung carcinoma.
Cancer research 1995;55(14):2968-71.
1995: Jan Vijg; Jeanne Y Wei
Understanding the biology of aging: the key to prevention and therapy.
Journal of the American Geriatrics Society 1995;43(4):426-34.
1995: Jan Vijg
Detecting individual genetic variation.
Bio/technology (Nature Publishing Company) 1995;13(2):137-9.
1995: Anders D Børglum; E Mullaart; A B Kvistgaard; André G Uitterlinden; Jan Vijg; Torben A Kruse
Two-dimensional DNA typing as a genetic marker system in humans.
Cytogenetics and cell genetics 1995;71(3):260-5.
1994: Jan Vijg; Y Wu; André G Uitterlinden; E Mullaart
Two-dimensional DNA electrophoresis in mutation detection.
Mutation research 1994;308(2):205-14.
1994: J A Gossen; W J de Leeuw; Jan Vijg
LacZ transgenic mouse models: their application in genetic toxicology.
Mutation research 1994;307(2):451-9.
1994: A M Verwest; W J de Leeuw; A C Molijn; T I Andersen; A L Börresen; E Mullaart; André G Uitterlinden; Jan Vijg
Genome scanning of breast cancers by two-dimensional DNA typing.
British journal of cancer 1994;69(1):84-92.
1993: Gerard te Meerman; E Mullaart; MA van der Meulen; J H den Daas; Bruno Morolli; André G Uitterlinden; Jan Vijg
Linkage analysis by two-dimensional DNA typing.
American journal of human genetics 1993;53(6):1289-97.
1993: ME Boerrigter; C Franceschi; E Arrigoni-Martelli; Jeanne Y Wei; Jan Vijg
The effect of L-carnitine and acetyl-L-carnitine on the disappearance of DNA single-strand breaks in human peripheral blood lymphocytes.
Carcinogenesis 1993;14(10):2131-6.
1993: E Mullaart; G J de Vos; Gerard te Meerman; André G Uitterlinden; Jan Vijg
Parallel genome analysis by two-dimensional DNA typing.
Nature 1993;365(6445):469-71.
1993: G J Trommelen; J H Den Daas; Jan Vijg; André G Uitterlinden
DNA profiling of cattle using micro- and minisatellite core probes.
Animal genetics 1993;24(4):235-41.
1993: Eivind Hovig; E Mullaart; A L Børresen; André G Uitterlinden; Jan Vijg
Genome scanning of human breast carcinomas using micro- and minisatellite core probes.
Genomics 1993;17(1):66-75.
1993: G J Trommelen; N H Den Daas; Jan Vijg; André G Uitterlinden
Identity and paternity testing of cattle: application of a deoxyribonucleic acid profiling protocol.
Journal of dairy science 1993;76(5):1403-11.
1993: J A Gossen; W J de Leeuw; A Q Bakker; Jan Vijg
DNA sequence analysis of spontaneous mutations at a LacZ transgene integrated on the mouse X chromosome.
Mutagenesis 1993;8(3):243-7.
1993: J A Gossen; W J de Leeuw; A C Molijn; Jan Vijg
Plasmid rescue from transgenic mouse DNA using LacI repressor protein conjugated to magnetic beads.
BioTechniques 1993;14(4):624-9.
1993: Jan Vijg; J A Gossen
Somatic mutations and cellular aging.
Comparative biochemistry and physiology. B, Comparative biochemistry 1993;104(3):429-37.
1993: I Meulenbelt; M C Wapenaar; D Patterson; Jan Vijg; André G Uitterlinden
Isolation and mapping of human chromosome 21 cosmids using a probe for RTVL-H retrovirus-like elements.
Genomics 1993;15(3):492-9.
1993: J A Gossen; Jan Vijg
A selective system for lacZ- phage using a galactose-sensitive E. coli host.
BioTechniques 1993;14(3):326, 330.
1993: A J Hoorn; L L Custer; B C Myhr; D Brusick; J Gossen; Jan Vijg
Detection of chemical mutagens using Muta Mouse: a transgenic mouse model.
Mutagenesis 1993;8(1):7-10.
1993: ME Boerrigter; Jan Vijg
Studies on DNA repair defects in degenerative brain disease.
Age and ageing 1993;22(1):S44-52.
1993: J Gossen; Jan Vijg
Transgenic mice as model systems for studying gene mutations in vivo.
Trends in genetics : TIG 1993;9(1):27-31.
1993: ME Boerrigter; Y Yin; Jan Vijg; Jeanne Y Wei
DNA repair in congenic mice: possible influence of a chromosome 4 genetic region on the rate of benzo[a]pyrene-induced DNA adduct removal.
Journal of gerontology 1993;48(1):B11-6.
1992: P Eline Slagboom; Jan Vijg
The dynamics of genome organization and expression during the aging process.
Annals of the New York Academy of Sciences 1992;673():58-69.
1992: Jan Vijg; W J de Leeuw; G R Douglas; J A Gossen
Transgenic mice and age-related mutations.
Annals of the New York Academy of Sciences 1992;663():26-35.
1992: M E Boerrigter; J Y Wei; Jan Vijg
DNA repair and Alzheimer's disease.
Journal of gerontology 1992;47(6):B177-84.
1992: J A Gossen; A C Molijn; G R Douglas; Jan Vijg
Application of galactose-sensitive E. coli strains as selective hosts for LacZ- plasmids.
Nucleic acids research 1992;20(12):3254.
1992: W Huppes; C J De Groot; R H Ostendorf; J G Bauman; J A Gossen; V Smit; Jan Vijg; Christine D Dijkstra
Detection of migrated allogeneic oligodendrocytes throughout the central nervous system of the galactocerebrosidase-deficient twitcher mouse.
Journal of neurocytology 1992;21(2):129-36.
1992: M E Boerrigter; Jan Vijg
Single-strand break disappearance in quiescent and phytohaemagglutinin-stimulated human peripheral blood lymphocytes exposed to a single low dose of gamma-radiation.
International journal of radiation biology 1992;61(1):95-101.
1991: J A Gossen; W J de Leeuw; A Verwest; P H Lohman; Jan Vijg
High somatic mutation frequencies in a LacZ transgene integrated on the mouse X-chromosome.
Mutation research 1991;250(1-2):423-9.
1991: M E Boerrigter; Jan Vijg
Induction and disappearance of DNA single-strand breaks in human B and T lymphocytes after exposure to ethylnitrosourea.
Mutation research 1991;255(1):49-55.
1991: M E Boerrigter; C.M. Duijn; E Mullaart; Piet Eikelenboom; C M van der Togt; D L Knook; Albert Hofman; Jan Vijg
Decreased DNA repair capacity in familial, but not in sporadic Alzheimer's disease.
Neurobiology of aging 1991;12(4):367-70.
1991: P Eline Slagboom; André G Uitterlinden; Jan Vijg
Methylation status of cKi-ras and MHC genes in rat pituitary glands during aging and tumorigenesis.
Aging (Milan, Italy) 1991;3(2):141-6.
1991: P Eline Slagboom; E Mullaart; S Droog; Jan Vijg
Somatic mutations and cellular aging: two-dimensional DNA typing of rat fibroblast clones.
Mutation research 1991;256(2-6):311-21.
1991: André G Uitterlinden; E P Slagboom; E Mullaart; I Meulenbelt; Jan Vijg
Genome scanning by two-dimensional DNA typing: the use of repetitive DNA sequences for rapid mapping of genetic traits.
Electrophoresis 1991;12(2-3):119-34.
1991: M E Boerrigter; E Mullaart; F Berends; Jan Vijg
Induction and disappearance of DNA strand breaks and/or alkali-labile sites in human lymphocytes exposed to N-ethyl-N-nitrosourea.
Carcinogenesis 1991;12(1):77-82.
1991: M E Boerrigter; E Mullaart; Jan Vijg
Induction and disappearance of DNA strand breaks in human peripheral blood lymphocytes and fibroblasts treated with methyl methanesulfonate.
Experimental cell research 1991;192(1):61-6.
1991: Jan Vijg; J A Gossen; W J De Leeuw; E Mullaart; P Eline Slagboom; André G Uitterlinden
DNA processing, aging, and cancer. The impact of new technology.
Annals of the New York Academy of Sciences 1991;621():53-65.
1991: Jan Vijg
New methods for the detection of genetic variation.
Annali dell'Istituto superiore di sanità 1991;27(1):123-6.
1991: J A Gossen; W J de Leeuw; M Verwest; Jan Vijg
Analysis of spontaneous and induced mutation frequencies in transgenic mice using a lambda shuttle vector system.
Progress in clinical and biological research 1991;372():313-8.
1991: A G Uitterlinden; Jan Vijg
Denaturing gradient gel electrophoretic analysis of minisatellite alleles.
Electrophoresis 1991;12(1):12-6.
1990: Jan Vijg
[Extension of life: the apotheosis of the molecular biomedical sciences?].
Tijdschrift voor gerontologie en geriatrie 1990;21(5):199-204.
1990: Jan Vijg; J Papaconstantinou
Aging and longevity genes: strategies for identifying DNA sequences controlling life span.
Journal of gerontology 1990;45(5):B179-82.
1990: Jan Vijg
Searching for the molecular basis of aging: the need for life extension models.
Aging (Milan, Italy) 1990;2(3):227-9.
1990: E Mullaart; P H Lohman; F Berends; Jan Vijg
DNA damage metabolism and aging.
Mutation research 1990;237(5-6):189-210.
1990: P Eline Slagboom; W J de Leeuw; Jan Vijg
mRNA levels and methylation patterns of the tyrosine aminotransferase gene in aging inbred rats.
FEBS letters 1990;269(1):128-30.
1990: Jan Vijg
DNA sequence changes in aging: how frequent, how important?
Aging (Milan, Italy) 1990;2(2):105-23.
1990: E Mullaart; M E Boerrigter; Rivka Ravid; Dick F Swaab; Jan Vijg
Increased levels of DNA breaks in cerebral cortex of Alzheimer's disease patients.
Neurobiology of aging 1990;11(3):169-73.
1990: M E Boerrigter; E Mullaart; G P van der Schans; Jan Vijg
Illusory DNA breaks in quiescent lymphocytes?
Experimental cell research 1990;188(1):1.
1990: P Eline Slagboom; W J de Leeuw; Jan Vijg
Messenger RNA levels and methylation patterns of GAPDH and beta-actin genes in rat liver, spleen and brain in relation to aging.
Mechanisms of ageing and development 1990;53(3):243-57.
1990: Adayapalam T Natarajan; S E Vlasblom; A Manca; Paul H M Lohman; J A Gossen; Jan Vijg; Friedrich Beermann; Edith Hummler; I Hansmann
Transgenic mouse--an in vivo system for detection of aneugens.
Progress in clinical and biological research 1990;340B():295-9.
1990: J A Gossen; Jan Vijg
Transgenic mice as a model to study gene mutations: application as a short-term mutagenicity assay.
Progress in clinical and biological research 1990;340A():347-54.
1990: E Mullaart; M E Boerrigter; G J Boer; Jan Vijg
Spontaneous DNA breaks in the rat brain during development and aging.
Mutation research 1990;237(1):9-15.
1990: André G Uitterlinden; Jan Vijg
Denaturing gradient gel electrophoretic analysis of the human cHa-ras1 proto-oncogene.
Applied and theoretical electrophoresis : the official journal of the International Electrophoresis Society 1990;1(4):175-9.
1989: André G Uitterlinden; P Eline Slagboom; Thomas Johnson; Jan Vijg
The Caenorhabditis elegans genome contains monomorphic minisatellites and simple sequences.
Nucleic acids research 1989;17(23):9527-30.
1989: W J de Leeuw; P Eline Slagboom; Jan Vijg
Quantitative comparison of mRNA levels in mammalian tissues: 28S ribosomal RNA level as an accurate internal control.
Nucleic acids research 1989;17(23):10137-8.
1989: J A Gossen; W J de Leeuw; C H Tan; E C Zwarthoff; F Berends; P H Lohman; D L Knook; Jan Vijg
Efficient rescue of integrated shuttle vectors from transgenic mice: a model for studying mutations in vivo.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(20):7971-5.
1989: J J Gille; Carola G M van Berkel; E Mullaart; Jan Vijg; Hans Joenje
Effects of lethal exposure to hyperoxia and to hydrogen peroxide on NAD(H) and ATP pools in Chinese hamster ovary cells.
Mutation research 1989;214(1):89-96.
1989: André G Uitterlinden; P Eline Slagboom; D L Knook; Jan Vijg
Two-dimensional DNA fingerprinting of human individuals.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(8):2742-6.
1989: Jan Vijg
Molecular gerontology needs coordination.
Mutation research 1989;219(2):87-8.
1989: C Franceschi; Richard setlow; T Sugimura; Jan Vijg
About an old problem, new approaches, a new section.
Mutation research 1989;219(2):83-5.
1989: E Mullaart; L Roza; P H Lohman; Jan Vijg
The removal of UV-induced pyrimidine dimers from DNA of rat skin cells in vitro and in vivo in relation to aging.
Mechanisms of ageing and development 1989;47(3):253-64.
1989: M E Boerrigter; E Mullaart; G P van der Schans; Jan Vijg
Quiescent human peripheral blood lymphocytes do not contain a sizable amount of preexistent DNA single-strand breaks.
Experimental cell research 1989;180(2):569-73.
1989: E Mullaart; M Buytenhek; A Brouwer; P H Lohman; Jan Vijg
Genotoxic effects of intragastrically administered benzo[a]pyrene in rat liver and intestinal cells.
Carcinogenesis 1989;10(2):393-5.
1989: J J Gille; E Mullaart; Jan Vijg; A L Leyva; Fré Arwert; Hans Joenje
Chromosomal instability in an oxygen-tolerant variant of Chinese hamster ovary cells.
Mutation research 1989;219(1):17-28.
1989: E Mullaart; M E Boerrigter; P H Lohman; Jan Vijg
Age-related induction and disappearance of carcinogen-DNA-adducts in livers of rats exposed to low levels of 2-acetylaminofluorene.
Chemico-biological interactions 1989;69(4):373-84.
1989: P E Slagboom; Jan Vijg
Genetic instability and aging: theories, facts, and future perspectives.
Genome / National Research Council Canada = Génome / Conseil national de recherches Canada 1989;31(1):373-85.
1988: J A Gossen; Jan Vijg
E. coli C: a convenient host strain for rescue of highly methylated DNA.
Nucleic acids research 1988;16(19):9343.
1988: E Mullaart; M E Boerrigter; A Brouwer; F Berends; Jan Vijg
Age-dependent accumulation of alkali-labile sites in DNA of post-mitotic but not in that of mitotic rat liver cells.
Mechanisms of ageing and development 1988;45(1):41-9.
1988: C Franceschi; Richard setlow; T Sugimura; Jan Vijg
About an old problem, new approaches, a new section.
Mutation research 1988;():3-5.
1988: E Mullaart; P H Lohman; Jan Vijg
Differences in pyrimidine dimer removal between rat skin cells in vitro and in vivo.
The Journal of investigative dermatology 1988;90(3):346-9.
1987: P H Lohman; Jan Vijg; André G Uitterlinden; P Eline Slagboom; J A Gossen; F Berends
DNA methods for detecting and analyzing mutations in vivo.
Mutation research 1987;181(2):227-34.
1987: Jan Vijg; A G Uitterlinden
A search for DNA alterations in the aging mammalian genome: an experimental strategy.
Mechanisms of ageing and development 1987;41(1-2):47-63.
1987: Jan Vijg; D L Knook
DNA repair in relation to the aging process.
Journal of the American Geriatrics Society 1987;35(6):532-41.
1987: Claudia Gravekamp; L P van den Bulck; Jan Vijg; R J van de Griend; Reinder L H Bolhuis
c-myc gene expression and interleukin-2 receptor levels in cloned human CD2+,CD3+ and CD2+,CD3- lymphocytes.
Natural immunity and cell growth regulation 1987;6(1):28-36.
1986: Jan Vijg; E Mullaart; F Berends; P H Lohman; D L Knook
UV-induced DNA excision repair in rat fibroblasts during immortalization and terminal differentiation in vitro.
Experimental cell research 1986;167(2):517-30.
1986: Jan Vijg; E Mullaart; L Roza; R A Baan; P H Lohman
Immunochemical detection of DNA in alkaline sucrose gradient fractions.
Journal of immunological methods 1986;91(1):53-8.
1986: Jan Vijg; L Roza; E Mullaart; P H Lohman
Species specificity in the induction and repair of DNA damage.
Progress in clinical and biological research 1986;209A():179-87.
1985: Jan Vijg; E Mullaart; P H Lohman; D L Knook
UV-induced unscheduled DNA synthesis in fibroblasts of aging inbred rats.
Mutation research 1985;146(2):197-204.
1985: A G Uitterlinden; Jan Vijg; M J Giphart; D L Knook
Variation in restriction fragment length and methylation pattern of rat MHC class I genes.
Experimental and clinical immunogenetics 1985;2(4):215-22.
1984: Jan Vijg; E Mullaart; G P van der Schans; P H Lohman; D L Knook
Kinetics of ultraviolet induced DNA excision repair in rat and human fibroblasts.
Mutation research 1984;132(3-4):129-38.
1983: G H Schaap; A Verkerk; Jan Vijg; J F Jongkind
Flow sorting in the study of cell-cell interaction.
Cytometry 1983;3(6):408-13.