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Frederick Villamena

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TOP 3
Pedro L Zamora; Frederick A Villamena
Pharmacological approaches to the treatment of oxidative stress-induced cardiovascular dysfunctions.
Yuguang Song; Frederick A Villamena; Craig Hemann; Yangping Liu; Jay L Zweier
Esterified dendritic TAM radicals with very high stability and enhanced oxygen sensitivity.
Yangping Liu; Antal Rockenbauer; Yuguang Song; Frederick A Villamena; Jay L Zweier
Structural factors controlling the spin-spin exchange coupling: EPR spectroscopic studies of highly asymmetric trityl-nitroxide biradicals.

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All Publications

2013: Pedro L Zamora; Frederick A Villamena
Pharmacological approaches to the treatment of oxidative stress-induced cardiovascular dysfunctions.
Future medicinal chemistry 2013;5(4):465-78.
2013: Yuguang Song; Frederick A Villamena; Craig Hemann; Yangping Liu; Jay L Zweier
Esterified dendritic TAM radicals with very high stability and enhanced oxygen sensitivity.
The Journal of organic chemistry 2013;78(4):1371-6.
2013: Yangping Liu; Antal Rockenbauer; Yuguang Song; Frederick A Villamena; Jay L Zweier
Structural factors controlling the spin-spin exchange coupling: EPR spectroscopic studies of highly asymmetric trityl-nitroxide biradicals.
Journal of the American Chemical Society 2013;135(6):2350-6.
2012: Daniel Arango; Michael A Freitas; Erich Grotewold; Arti Parihar; Frederick A Villamena; Liwen Wang; Andrea I Doseff
Apigenin induces DNA damage through the PKCδ-dependent activation of ATM and H2AX causing down-regulation of genes involved in cell cycle control and DNA repair.
Biochemical pharmacology 2012;84(12):1571-80.
2012: Yangping Liu; Yuguang Song; Frederick A Villamena; Francesco De Pascali; Xiaoping Liu; Jay L Zweier
Tetrathiatriarylmethyl radical with a single aromatic hydrogen as a highly sensitive and specific superoxide probe.
Free radical biology & medicine 2012;53(11):2081-91.
2012: Mariana Spulber; Shulamith Schlick; Frederick A Villamena
Guest inclusion in cucurbiturils studied by ESR and DFT: the case of nitroxide radicals and spin adducts of DMPO and MNP.
The journal of physical chemistry. A 2012;116(33):8475-83.
2012: Kevin M Nash; Antal Rockenbauer; Frederick A Villamena
Reactive nitrogen species reactivities with nitrones: theoretical and experimental studies.
Chemical research in toxicology 2012;25(8):1581-97.
2012: Amlan Das; Andrea I Doseff; Bhavani Gopalakrishnan; Oliver H Voss; Frederick A Villamena
Inhibition of ROS-induced apoptosis in endothelial cells by nitrone spin traps via induction of phase II enzymes and suppression of mitochondria-dependent pro-apoptotic signaling.
Biochemical pharmacology 2012;84(4):486-97.
2012: Pedro L Zamora; Frederick A Villamena
Theoretical and experimental studies of the spin trapping of inorganic radicals by 5,5-dimethyl-1-pyrroline N-oxide (DMPO). 3. Sulfur dioxide, sulfite, and sulfate radical anions.
The journal of physical chemistry. A 2012;116(26):7210-8.
2012: Frederick A Villamena; Amlan Das; Kevin M Nash
Potential implication of the chemical properties and bioactivity of nitrone spin traps for therapeutics.
Future medicinal chemistry 2012;4(9):1171-207.
2012: Fanny Choteau; Bernard Pucci; Béatrice Tuccio; Frederick A Villamena; Laurence Charles; Grégory Durand
Synthesis of tris-hydroxymethyl-based nitrone derivatives with highly reactive nitronyl carbon.
The Journal of organic chemistry 2012;77(2):938-48.
2012: Shang-U Kim; Frederick A Villamena
Reactivities of superoxide and hydroperoxyl radicals with disubstituted cyclic nitrones: a DFT study.
The journal of physical chemistry. A 2012;116(2):886-98.
2012: Christopher J Traynham; Serge Viatchenko-Karpinski; Frederick A Villamena; Honglan Wang; George E Billman; Dominic J Catalano; Sandor Gyorke; Yongbin Han; Hsiang-Ting Ho; Xin Huang; Shang-U Kim; Robert A Prosak; Ira O Racoma; Steve R Roof; Lifei Tang; Mark T Ziolo
Diesterified nitrone rescues nitroso-redox levels and increases myocyte contraction via increased SR Ca(2+) handling.
PloS one 2012;7(12):e52005.
2012: Bhavani Gopalakrishnan; Kevin M Nash; Murugesan Velayutham; Frederick A Villamena
Detection of nitric oxide and superoxide radical anion by electron paramagnetic resonance spectroscopy from cells using spin traps.
Journal of visualized experiments : JoVE 2012;(66):e2810.
2011: Yangping Liu; Yuguang Song; Antal Rockenbauer; Jian Sun; Craig Hemann; Frederick A Villamena; Jay L Zweier
Synthesis of trityl radical-conjugated disulfide biradicals for measurement of thiol concentration.
The Journal of organic chemistry 2011;76(10):3853-60.
2010: Shang-U Kim; Yangping Liu; Kevin M Nash; Antal Rockenbauer; Jay L Zweier; Frederick A Villamena
Fast reactivity of a cyclic nitrone-calix[4]pyrrole conjugate with superoxide radical anion: theoretical and experimental studies.
Journal of the American Chemical Society 2010;132(48):17157-73.
2010: Grégory Durand; Burkhard Poeggeler; Stéphanie Ortial; Ange Polidori; Frederick A Villamena; Jutta Böker; Rüdiger Hardeland; Miguel Pappolla; Bernard Pucci
Amphiphilic amide nitrones: a new class of protective agents acting as modifiers of mitochondrial metabolism.
Journal of medicinal chemistry 2010;53(13):4849-61.
2010: Yangping Liu; Frederick A Villamena; Antal Rockenbauer; Jay L Zweier
Trityl-nitroxide biradicals as unique molecular probes for the simultaneous measurement of redox status and oxygenation.
Chemical communications (Cambridge, England) 2010;46(4):628-30.
2010: Frederick A Villamena
Superoxide radical anion adduct of 5,5-dimethyl-1-pyrroline N-oxide. 6. Redox properties.
The journal of physical chemistry. A 2010;114(2):1153-60.
2010: Jinhua Wang; Vinh Dang; Wei Zhao; Dongning Lu; Brian K Rivera; Frederick A Villamena; Peng George Wang; Periannan Kuppusamy
Perchlorotrityl radical-fluorophore conjugates as dual fluorescence and EPR probes for superoxide radical anion.
Bioorganic & medicinal chemistry 2010;18(2):922-9.
2009: Grégory Durand; Robert A Prosak; Yongbin Han; Stéphanie Ortial; Antal Rockenbauer; Bernard Pucci; Frederick A Villamena
Spin trapping and cytoprotective properties of fluorinated amphiphilic carrier conjugates of cyclic versus linear nitrones.
Chemical research in toxicology 2009;22(9):1570-81.
2009: Yongbin Han; Yangping Liu; Antal Rockenbauer; Jay L Zweier; Grégory Durand; Frederick A Villamena
Lipophilic beta-cyclodextrin cyclic-nitrone conjugate: synthesis and spin trapping studies.
The Journal of organic chemistry 2009;74(15):5369-80.
2009: Frederick A Villamena
Superoxide radical anion adduct of 5,5-dimethyl-1-pyrroline N-oxide. 5. Thermodynamics and kinetics of unimolecular decomposition.
The journal of physical chemistry. A 2009;113(22):6398-403.
2009: Li Zuo; Yeong-Renn Chen; Levy A Reyes; Hsin-Ling Lee; Chwen-Lih Chen; Frederick A Villamena; Jay L Zweier
The radical trap 5,5-dimethyl-1-pyrroline N-oxide exerts dose-dependent protection against myocardial ischemia-reperfusion injury through preservation of mitochondrial electron transport.
The Journal of pharmacology and experimental therapeutics 2009;329(2):515-23.
2009: Yangping Liu; Frederick A Villamena; Jian Sun; Tse-yao Wang; Jay L Zweier
Esterified trityl radicals as intracellular oxygen probes.
Free radical biology & medicine 2009;46(7):876-83.
2008: Frederick A Villamena; Yangping Liu; Jay L Zweier
Superoxide radical anion adduct of 5,5-dimethyl-1-pyrroline N-oxide. 4. Conformational effects on the EPR hyperfine splitting constants.
The journal of physical chemistry. A 2008;112(49):12607-15.
2008: Grégory Durand; Fanny Choteau; Bernard Pucci; Frederick A Villamena
Reactivity of superoxide radical anion and hydroperoxyl radical with alpha-phenyl-N-tert-butylnitrone (PBN) derivatives.
The journal of physical chemistry. A 2008;112(48):12498-509.
2008: Steven M Field; Frederick A Villamena
Theoretical and experimental studies of tyrosyl hydroperoxide formation in the presence of H-bond donors.
Chemical research in toxicology 2008;21(10):1923-32.
2008: Yangping Liu; Frederick A Villamena; Jay L Zweier
Highly stable dendritic trityl radicals as oxygen and pH probe.
Chemical communications (Cambridge, England) 2008;(36):4336-8.
2008: Yongbin Han; Béatrice Tuccio; Robert Lauricella; Frederick A Villamena
Improved spin trapping properties by beta-cyclodextrin-cyclic nitrone conjugate.
The Journal of organic chemistry 2008;73(18):7108-17.
2008: Yongbin Han; Béatrice Tuccio; Robert Lauricella; Antal Rockenbauer; Jay L Zweier; Frederick A Villamena
Synthesis and spin-trapping properties of a new spirolactonyl nitrone.
The Journal of organic chemistry 2008;73(7):2533-41.
2008: Mordhwaj Parihar; Arti Parihar; Frederick A Villamena; Patrick S Vaccaro; Pedram Ghafourifar
Inactivation of mitochondrial respiratory chain complex I leads mitochondrial nitric oxide synthase to become pro-oxidative.
Biochemical and biophysical research communications 2008;367(4):761-7.
2008: Randy A Burgett; Xiaofeng Bao; Frederick A Villamena
Superoxide radical anion adduct of 5,5-dimethyl-1-pyrroline N-oxide (DMPO). 3. Effect of mildly acidic pH on the thermodynamics and kinetics of adduct formation.
The journal of physical chemistry. A 2008;112(11):2447-55.
2008: Yangping Liu; Frederick A Villamena; Jian Sun; Yingkai Xu; Ilirian Dhimitruka; Jay L Zweier
Synthesis and characterization of ester-derivatized tetrathiatriarylmethyl radicals as intracellular oxygen probes.
The Journal of organic chemistry 2008;73(4):1490-7.
2008: Vijay Kumar Kutala; Frederick A Villamena; Govindasamy Ilangovan; daniel maspoch ; Nans Roques; Jaume Veciana; Concepció Rovira; Periannan Kuppusamy
Reactivity of superoxide anion radical with a perchlorotriphenylmethyl (trityl) radical.
The journal of physical chemistry. B 2008;112(1):158-67.
2007: Ilirian Dhimitruka; Murugesan Velayutham; Andrey A Bobko; Valery V Khramtsov; Frederick A Villamena; Christopher M Hadad; Jay L Zweier
Large-scale synthesis of a persistent trityl radical for use in biomedical EPR applications and imaging.
Bioorganic & medicinal chemistry letters 2007;17(24):6801-5.
2007: Frederick A Villamena; John K Merle; Christopher M Hadad; Jay L Zweier
Rate constants of hydroperoxyl radical addition to cyclic nitrones: a DFT study.
The journal of physical chemistry. A 2007;111(39):9995-10001.
2007: Vinh Dang; Jinhua Wang; Song Feng; Christophe Buron; Frederick A Villamena; Peng George Wang; Periannan Kuppusamy
Synthesis and characterization of a perchlorotriphenylmethyl (trityl) triester radical: a potential sensor for superoxide and oxygen in biological systems.
Bioorganic & medicinal chemistry letters 2007;17(14):4062-5.
2007: Frederick A Villamena; Shijing Xia; John K Merle; Robert Lauricella; Béatrice Tuccio; Christopher M Hadad; Jay L Zweier
Reactivity of superoxide radical anion with cyclic nitrones: role of intramolecular H-bond and electrostatic effects.
Journal of the American Chemical Society 2007;129(26):8177-91.
2007: Dongning Lu; Janos Nadas; Guisheng Zhang; Wesley Johnson; Jay L Zweier; Arturo J Cardounel; Frederick A Villamena; Peng George Wang
4-Aryl-1,3,2-oxathiazolylium-5-olates as pH-controlled NO-donors: the next generation of S-nitrosothiols.
Journal of the American Chemical Society 2007;129(17):5503-14.
2007: Frederick A Villamena; Edward J Locigno; Antal Rockenbauer; Christopher M Hadad; Jay L Zweier
Theoretical and experimental studies of the spin trapping of inorganic radicals by 5,5-dimethyl-1-pyrroline N-oxide (DMPO). 2. Carbonate radical anion.
The journal of physical chemistry. A 2007;111(2):384-91.
2006: Frederick A Villamena; Edward J Locigno; Antal Rockenbauer; Christopher M Hadad; Jay L Zweier
Theoretical and experimental studies of the spin trapping of inorganic radicals by 5,5-dimethyl-1-pyrroline N-oxide (DMPO). 1. Carbon dioxide radical anion.
The journal of physical chemistry. A 2006;110(49):13253-8.
2006: Shijing Xia; Frederick A Villamena; Christopher M Hadad; Periannan Kuppusamy; Yunbo Li; Hong Zhu; Jay L Zweier
Reactivity of molecular oxygen with ethoxycarbonyl derivatives of tetrathiatriarylmethyl radicals.
The Journal of organic chemistry 2006;71(19):7268-79.
2006: Diana Visinescu; Cédric Desplanches; Inhar Imaz; Vincent Bahers; Rabindranath Pradhan; Frederick A Villamena; Philippe Guionneau; Jean-Pascal Sutter
Evidence for increased exchange interactions with 5d compared to 4d metal ions. Experimental and theoretical insights into the ferromagnetic interactions of a series of trinuclear [{M(CN)8}3-/NiII] compounds (M = MoV or WV).
Journal of the American Chemical Society 2006;128(31):10202-12.
2005: Edward J Locigno; Jay L Zweier; Frederick A Villamena
Nitric oxide release from the unimolecular decomposition of the superoxide radical anion adduct of cyclic nitrones in aqueous medium.
Organic & biomolecular chemistry 2005;3(17):3220-7.
2005: Frederick A Villamena; John K Merle; Christopher M Hadad; Jay L Zweier
Superoxide radical anion adduct of 5,5-dimethyl-1-pyrroline N-oxide (DMPO). 2. The thermodynamics of decay and EPR spectral properties.
The journal of physical chemistry. A 2005;109(27):6089-98.
2005: Frederick A Villamena; John K Merle; Christopher M Hadad; Jay L Zweier
Superoxide radical anion adduct of 5,5-dimethyl-1-pyrroline n-oxide (DMPO). 1. The thermodynamics of formation and its acidity.
The journal of physical chemistry. A 2005;109(27):6083-8.
2005: Murugesan Velayutham; Frederick A Villamena; Mettachit Navamal; James C Fishbein; Jay L Zweier
Glutathione-mediated formation of oxygen free radicals by the major metabolite of oltipraz.
Chemical research in toxicology 2005;18(6):970-5.
2005: Frederick A Villamena; Christopher M Hadad; Jay L Zweier
Comparative DFT study of the spin trapping of methyl, mercapto, hydroperoxy, superoxide, and nitric oxide radicals by various substituted cyclic nitrones.
The journal of physical chemistry. A 2005;109(8):1662-74.
2005: Murugesan Velayutham; Frederick A Villamena; James C Fishbein; Jay L Zweier
Cancer chemopreventive oltipraz generates superoxide anion radical.
Archives of biochemistry and biophysics 2005;435(1):83-8.
2004: Frederick A Villamena; Antal Rockenbauer; Judith C Gallucci; Murugesan Velayutham; Christopher M Hadad; Jay L Zweier
Spin trapping by 5-carbamoyl-5-methyl-1-pyrroline N-oxide (AMPO): theoretical and experimental studies.
The Journal of organic chemistry 2004;69(23):7994-8004.
2004: Frederick A Villamena; Jay L Zweier
Detection of reactive oxygen and nitrogen species by EPR spin trapping.
Antioxidants & redox signaling 2004;6(3):619-29.
2004: Frederick A Villamena; Christopher M Hadad; Jay L Zweier
Theoretical study of the spin trapping of hydroxyl radical by cyclic nitrones: a density functional theory approach.
Journal of the American Chemical Society 2004;126(6):1816-29.
2002: Mettachit Navamal; Colleen McGrath; Jennifer Stewart; Patrick Blans; Frederick A Villamena; Jay L Zweier; James C Fishbein
Thiolytic chemistry of alternative precursors to the major metabolite of the cancer chemopreventive oltipraz.
The Journal of organic chemistry 2002;67(26):9406-13.