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Bente Vilsen

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Co-Publications
Name
47
Andersen, Jens Peter
12
Toustrup-Jensen, Mads
9
Clausen, Johannes
8
Einholm, Anja Pernille
7
McIntosh, David
6
Woolley, David
5
Nissen, Poul
4
Dode, Leonard
3
MacLennan, David
3
Morth, Preben
3
Anthonisen, Anne Nyholm
3
Wuytack, Frank
3
Sorensen, TL
2
Sørensen, Thomas Lykke-Møller
2
Olesen, Claus

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Publications

TOP 3
Clapcote Steven J; Duffy Steven; Xie Gang; Kirshenbaum Greer; Bechard Allison R; Rodacker Schack Vivien; Petersen Janne; Sinai Laleh; Saab Bechara J; Lerch Jason P; Minassian Berge A; Ackerley Cameron A; Sled John G; Cortez Miguel A; Henderson Jeffrey T; Vilsen Bente; Roder John C
Mutation I810N in the alpha3 isoform of Na+,K+-ATPase causes impairments in the sodium pump and hyperexcitability in the CNS.
Toustrup-Jensen Mads S; Holm Rikke; Einholm Anja Pernille; Schack Vivien Rodacker; Morth J Preben; Nissen Poul; Andersen Jens Peter; Vilsen Bente
The C terminus of Na+,K+-ATPase controls Na+ affinity on both sides of the membrane through Arg935.
Blanco-Arias Patricia; Einholm Anja P; Mamsa Hafsa; Concheiro Carla; Gutiérrez-de-Terán Hugo; Romero Jesús; Toustrup-Jensen Mads S; Carracedo Angel; Jen Joanna C; Vilsen Bente; Sobrido María-Jesús
A C-terminal mutation of ATP1A3 underscores the crucial role of sodium affinity in the pathophysiology of rapid-onset dystonia-parkinsonism.

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All Publications

2009: Clapcote Steven J; Duffy Steven; Xie Gang; Kirshenbaum Greer; Bechard Allison R; Rodacker Schack Vivien; Petersen Janne; Sinai Laleh; Saab Bechara J; Lerch Jason P; Minassian Berge A; Ackerley Cameron A; Sled John G; Cortez Miguel A; Henderson Jeffrey T; Vilsen Bente; Roder John C
Mutation I810N in the alpha3 isoform of Na+,K+-ATPase causes impairments in the sodium pump and hyperexcitability in the CNS.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(33):14085-90.
2009: Toustrup-Jensen Mads S; Holm Rikke; Einholm Anja Pernille; Schack Vivien Rodacker; Morth J Preben; Nissen Poul; Andersen Jens Peter; Vilsen Bente
The C terminus of Na+,K+-ATPase controls Na+ affinity on both sides of the membrane through Arg935.
The Journal of biological chemistry 2009;284(28):18715-25.
2009: Blanco-Arias Patricia; Einholm Anja P; Mamsa Hafsa; Concheiro Carla; Gutiérrez-de-Terán Hugo; Romero Jesús; Toustrup-Jensen Mads S; Carracedo Angel; Jen Joanna C; Vilsen Bente; Sobrido María-Jesús
A C-terminal mutation of ATP1A3 underscores the crucial role of sodium affinity in the pathophysiology of rapid-onset dystonia-parkinsonism.
Human molecular genetics 2009;18(13):2370-7.
2009: Yatime Laure; Buch-Pedersen Morten J; Musgaard Maria; Morth J Preben; Lund Winther Anne-Marie; Pedersen Bjørn P; Olesen Claus; Andersen Jens Peter; Vilsen Bente; Schiøtt Birgit; Palmgren Michael G; Møller Jesper V; Nissen Poul; Fedosova Natalya
P-type ATPases as drug targets: tools for medicine and science.
Biochimica et biophysica acta 2009;1787(4):207-20.
2008: Schack Vivien Rodacker; Morth Jens Preben; Toustrup-Jensen Mads S; Anthonisen Anne Nyholm; Nissen Poul; Andersen Jens Peter; Vilsen Bente
Identification and function of a cytoplasmic K+ site of the Na+, K+ -ATPase.
The Journal of biological chemistry 2008;283(41):27982-90.
2008: Vilsen Bente
[The Na+,K+ pump continues to cause surprise]
Ugeskrift for laeger 2008;170(21):1821-3.
2008: Marchand Alexandre; Winther Anne-Marie Lund; Holm Peter Joakim; Olesen Claus; Montigny Cedric; Arnou Bertrand; Champeil Philippe; Clausen Johannes D; Vilsen Bente; Andersen Jens Peter; Nissen Poul; Jaxel Christine; Møller Jesper Vuust; le Maire Marc
Crystal structure of D351A and P312A mutant forms of the mammalian sarcoplasmic reticulum Ca(2+) -ATPase reveals key events in phosphorylation and Ca(2+) release.
The Journal of biological chemistry 2008;283(21):14867-82.
2007: Morth J Preben; Pedersen Bjørn P; Toustrup-Jensen Mads S; Sørensen Thomas L-M; Petersen Janne; Andersen Jens Peter; Vilsen Bente; Nissen Poul
Crystal structure of the sodium-potassium pump.
Nature 2007;450(7172):1043-9.
2007: Einholm Anja Pernille; Andersen Jens Peter; Vilsen Bente
Roles of transmembrane segment M1 of Na+,K+-ATPase and Ca2-ATPase, the gatekeeper and the pivot.
Journal of bioenergetics and biomembranes 2007;39(5-6):357-66.
2007: Einholm Anja Pernille; Andersen Jens Peter; Vilsen Bente
Importance of Leu99 in transmembrane segment M1 of the Na+, K+ -ATPase in the binding and occlusion of K+.
The Journal of biological chemistry 2007;282(33):23854-66.
2007: Clausen Johannes D; McIntosh David B; Anthonisen Anne Nyholm; Woolley David G; Vilsen Bente; Andersen Jens Peter
ATP-binding modes and functionally important interdomain bonds of sarcoplasmic reticulum Ca2+-ATPase revealed by mutation of glycine 438, glutamate 439, and arginine 678.
The Journal of biological chemistry 2007;282(28):20686-97.
2006: Rodacker Vivien; Toustrup-Jensen Mads; Vilsen Bente
Mutations Phe785Leu and Thr618Met in Na+,K+-ATPase, associated with familial rapid-onset dystonia parkinsonism, interfere with Na+ interaction by distinct mechanisms.
The Journal of biological chemistry 2006;281(27):18539-48.
2006: Clausen Johannes D; McIntosh David B; Woolley David G; Anthonisen Anne Nyholm; Vilsen Bente; Andersen Jens Peter
Asparagine 706 and glutamate 183 at the catalytic site of sarcoplasmic reticulum Ca2+-ATPase play critical but distinct roles in E2 states.
The Journal of biological chemistry 2006;281(14):9471-81.
2006: Dode Leonard; Andersen Jens Peter; Vanoevelen Jo; Raeymaekers Luc; Missiaen Ludwig; Vilsen Bente; Wuytack Frank
Dissection of the functional differences between human secretory pathway Ca2+/Mn2+-ATPase (SPCA) 1 and 2 isoenzymes by steady-state and transient kinetic analyses.
The Journal of biological chemistry 2006;281(6):3182-9.
2005: Dode Leonard; Andersen Jens Peter; Raeymaekers Luc; Missiaen Ludwig; Vilsen Bente; Wuytack Frank
Functional comparison between secretory pathway Ca2+/Mn2+-ATPase (SPCA) 1 and sarcoplasmic reticulum Ca2+-ATPase (SERCA) 1 isoforms by steady-state and transient kinetic analyses.
The Journal of biological chemistry 2005;280(47):39124-34.
2005: Einholm Anja Pernille; Toustrup-Jensen Mads; Andersen Jens Peter; Vilsen Bente
Mutation of Gly-94 in transmembrane segment M1 of Na+,K+-ATPase interferes with Na+ and K+ binding in E2P conformation.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(32):11254-9.
2005: Toustrup-Jensen Mads; Vilsen Bente
Interaction between the catalytic site and the A-M3 linker stabilizes E2/E2P conformational states of Na+,K+-ATPase.
The Journal of biological chemistry 2005;280(11):10210-8.
2004: Sørensen Thomas Lykke-Møller; Clausen Johannes D; Jensen Anne-Marie Lund; Vilsen Bente; Møller Jesper Vuust; Andersen Jens Peter; Nissen Poul
Localization of a K+ -binding site involved in dephosphorylation of the sarcoplasmic reticulum Ca2+ -ATPase.
The Journal of biological chemistry 2004;279(45):46355-8.
2004: McIntosh David B; Clausen Johannes D; Woolley David G; MacLennan David H; Vilsen Bente; Andersen Jens Peter
Roles of conserved P domain residues and Mg2+ in ATP binding in the ground and Ca2+-activated states of sarcoplasmic reticulum Ca2+-ATPase.
The Journal of biological chemistry 2004;279(31):32515-23.
2004: Einholm Anja Pernille; Vilsen Bente; Andersen Jens Peter
Importance of transmembrane segment M1 of the sarcoplasmic reticulum Ca2+-ATPase in Ca2+ occlusion and phosphoenzyme processing.
The Journal of biological chemistry 2004;279(16):15888-96.
2004: Clausen Johannes D; Vilsen Bente; McIntosh David B; Einholm Anja P; Andersen Jens Peter
Glutamate-183 in the conserved TGES motif of domain A of sarcoplasmic reticulum Ca2+-ATPase assists in catalysis of E2/E2P partial reactions.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(9):2776-81.
2003: Dode Leonard; Andersen Jens Peter; Leslie Natalie; Dhitavat Jittima; Vilsen Bente; Hovnanian Alain
Dissection of the functional differences between sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA) 1 and 2 isoforms and characterization of Darier disease (SERCA2) mutants by steady-state and transient kinetic analyses.
The Journal of biological chemistry 2003;278(48):47877-89.
2003: Toustrup-Jensen Mads; Vilsen Bente
Functional consequences of alterations to Ile279, Ile283, Glu284, His285, Phe286, and His288 in the NH2-terminal part of transmembrane helix M3 of the Na+,K(+)-ATPase.
The Journal of biological chemistry 2003;278(40):38653-64.
2003: Clausen Johannes D; McIntosh David B; Vilsen Bente; Woolley David G; Andersen Jens Peter
Importance of conserved N-domain residues Thr441, Glu442, Lys515, Arg560, and Leu562 of sarcoplasmic reticulum Ca2+-ATPase for MgATP binding and subsequent catalytic steps. Plasticity of the nucleotide-binding site.
The Journal of biological chemistry 2003;278(22):20245-58.
2003: Einholm Anja Pernille; Vilsen Bente; Andersen Jens Peter
Functional consequences of charge reversals of acidic residues in M1 of the SR Ca-ATPase.
Annals of the New York Academy of Sciences 2003;986():310-1.
2003: Toustrup-Jensen Mads; Vilsen Bente
Importance of Thr214 in the conserved TGES sequence of the Na+,K+-ATPase for vanadate binding and hydrolysis of E2P.
Annals of the New York Academy of Sciences 2003;986():267-9.
2003: McIntosh D B; Clausen J D; Woolley D G; MacLennan D H; Vilsen B; Andersen J P
ATP binding residues of sarcoplasmic reticulum Ca2+-ATPase.
Annals of the New York Academy of Sciences 2003;986():101-5.
2003: Andersen Jens Peter; Clausen Johannes D; Einholm Anja Pernille; Vilsen Bente
Mutagenesis of residues involved in control of the Ca2+ entry pathway and conformational changes associated with Ca2+ binding in the SR Ca2+-ATPase.
Annals of the New York Academy of Sciences 2003;986():72-81.
2003: Vilsen Bente; Toustrup-Jensen Mads
Importance of transmembrane segment M3 of Na+,K+-ATPase for control of conformational changes and the cytoplasmic entry pathway for Na.
Annals of the New York Academy of Sciences 2003;986():50-7.
2003: Toustrup-Jensen Mads; Vilsen Bente
Importance of conserved Thr214 in domain A of the Na+,K+ -ATPase for stabilization of the phosphoryl transition state complex in E2P dephosphorylation.
The Journal of biological chemistry 2003;278(13):11402-10.
2002: Dode Leonard; Vilsen Bente; Van Baelen Kurt; Wuytack Frank; Clausen Johannes D; Andersen Jens Peter
Dissection of the functional differences between sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA) 1 and 3 isoforms by steady-state and transient kinetic analyses.
The Journal of biological chemistry 2002;277(47):45579-91.
2002: Toustrup-Jensen Mads; Vilsen Bente
Importance of Glu(282) in transmembrane segment M3 of the Na(+),K(+)-ATPase for control of cation interaction and conformational changes.
The Journal of biological chemistry 2002;277(41):38607-17.
2001: Andersen J P; Sorensen T L; Povlsen K; Vilsen B
Importance of transmembrane segment M3 of the sarcoplasmic reticulum Ca2+-ATPase for control of the gateway to the Ca2+ sites.
The Journal of biological chemistry 2001;276(26):23312-21.
2001: Toustrup-Jensen M; Hauge M; Vilsen B
Mutational effects on conformational changes of the dephospho- and phospho-forms of the Na+,K+-ATPase.
Biochemistry 2001;40(18):5521-32.
2000: Sorensen T L; Dupont Y; Vilsen B; Andersen J P
Fast kinetic analysis of conformational changes in mutants of the Ca(2+)-ATPase of sarcoplasmic reticulum.
The Journal of biological chemistry 2000;275(8):5400-8.
1999: McIntosh D B; Woolley D G; MacLennan D H; Vilsen B; Andersen J P
Interaction of nucleotides with Asp(351) and the conserved phosphorylation loop of sarcoplasmic reticulum Ca(2+)-ATPase.
The Journal of biological chemistry 1999;274(36):25227-36.
1999: Vilsen B
Mutant Phe788 --> Leu of the Na+,K+-ATPase is inhibited by micromolar concentrations of potassium and exhibits high Na+-ATPase activity at low sodium concentrations.
Biochemistry 1999;38(35):11389-400.
1998: Andersen J P; Vilsen B
Structure-function relationships of the calcium binding sites of the sarcoplasmic reticulum Ca(2+)-ATPase.
Acta physiologica Scandinavica. Supplementum 1998;643():45-54.
1998: Vilsen B; Andersen J P
Mutation to the glutamate in the fourth membrane segment of Na+,K+-ATPase and Ca2+-ATPase affects cation binding from both sides of the membrane and destabilizes the occluded enzyme forms.
Biochemistry 1998;37(31):10961-71.
1997: Andersen J P; Sørensen T; Vilsen B
Site-directed mutagenesis analysis of the role of the M5S5 sector of the sarcoplasmic reticulum Ca(2+)-ATPase.
Annals of the New York Academy of Sciences 1997;834():333-8.
1997: Vilsen B; Ramlov D; Andersen J P
Functional consequences of mutations in the transmembrane core region for cation translocation and energy transduction in the Na+,K(+)-ATPase and the SR Ca(2+)-ATPase.
Annals of the New York Academy of Sciences 1997;834():297-309.
1997: Sorensen T; Vilsen B; Andersen J P
Mutation Lys758 --> Ile of the sarcoplasmic reticulum Ca2+-ATPase enhances dephosphorylation of E2P and inhibits the E2 to E1Ca2 transition.
The Journal of biological chemistry 1997;272(48):30244-53.
1997: Vilsen B
Leucine 332 at the boundary between the fourth transmembrane segment and the cytoplasmic domain of Na+,K+-ATPase plays a pivotal role in the ion translocating conformational changes.
Biochemistry 1997;36(43):13312-24.
1995: Vilsen B
Functional consequences of mutation Asn326-->Leu in the 4th transmembrane segment of the alpha-subunit of the rat kidney Na+, K(+)-ATPase.
FEBS letters 1995;363(1-2):179-83.
1995: Andersen J P; Vilsen B
Structure-function relationships of cation translocation by Ca(2+)- and Na+, K(+)-ATPases studied by site-directed mutagenesis.
FEBS letters 1995;359(2-3):101-6.
1995: Vilsen B
Mutant Glu781-->Ala of the rat kidney Na+,K(+)-ATPase displays low cation affinity and catalyzes ATP hydrolysis at a high rate in the absence of potassium ions.
Biochemistry 1995;34(4):1455-63.
1995: Vilsen B
Structure-function relationships in the Ca(2+)-ATPase of sarcoplasmic reticulum studied by use of the substrate analogue CrATP and site-directed mutagenesis. Comparison with the Na+,K(+)-ATPase.
Acta physiologica Scandinavica. Supplementum 1995;624():1-146.
1994: Nørregaard A; Vilsen B; Andersen J P
Transmembrane segment M3 is essential to thapsigargin sensitivity of the sarcoplasmic reticulum Ca(2+)-ATPase.
The Journal of biological chemistry 1994;269(43):26598-601.
1994: Andersen J P; Vilsen B
Amino acids Asn796 and Thr799 of the Ca(2+)-ATPase of sarcoplasmic reticulum bind Ca2+ at different sites.
The Journal of biological chemistry 1994;269(22):15931-6.
1993: Nørregaard A; Vilsen B; Andersen J P
Chimeric Ca(2+)-ATPase/Na+,K(+)-ATPase molecules. Their phosphoenzyme intermediates and sensitivity to Ca2+ and thapsigargin.
FEBS letters 1993;336(2):248-54.
1993: Vilsen B
Glutamate 329 located in the fourth transmembrane segment of the alpha-subunit of the rat kidney Na+,K+-ATPase is not an essential residue for active transport of sodium and potassium ions.
Biochemistry 1993;32(48):13340-9.
1993: Vilsen B
A Glu329-->Gln variant of the alpha-subunit of the rat kidney Na+,K(+)-ATPase can sustain active transport of Na+ and K+ and Na+,K(+)-activated ATP hydrolysis with normal turnover number.
FEBS letters 1993;333(1-2):44-50.
1993: Andersen J P; Vilsen B
Functional consequences of substitution of the seven-residue segment LysIleArgAspGlnMetAla240 located in the stalk helix S3 of the Ca(2+)-ATPase of sarcoplasmic reticulum.
Biochemistry 1993;32(38):10015-20.
1992: Vilsen B; Andersen J P
CrATP-induced Ca2+ occlusion in mutants of the Ca(2+)-ATPase of sarcoplasmic reticulum.
The Journal of biological chemistry 1992;267(36):25739-43.
1992: Vilsen B
Functional consequences of alterations to Pro328 and Leu332 located in the 4th transmembrane segment of the alpha-subunit of the rat kidney Na+,K(+)-ATPase.
FEBS letters 1992;314(3):301-7.
1992: Andersen J P; Vilsen B
Functional consequences of alterations to Glu309, Glu771, and Asp800 in the Ca(2+)-ATPase of sarcoplasmic reticulum.
The Journal of biological chemistry 1992;267(27):19383-7.
1992: Vilsen B; Andersen J P
Mutational analysis of the role of Glu309 in the sarcoplasmic reticulum Ca(2+)-ATPase of frog skeletal muscle.
FEBS letters 1992;306(2-3):247-50.
1992: Vilsen B; Andersen J P
Deduced amino acid sequence and E1-E2 equilibrium of the sarcoplasmic reticulum Ca(2+)-ATPase of frog skeletal muscle. Comparison with the Ca(2+)-ATPase of rabbit fast twitch muscle.
FEBS letters 1992;306(2-3):213-8.
1992: Vilsen B; Andersen J P
Interdependence of Ca2+ occlusion sites in the unphosphorylated sarcoplasmic reticulum Ca(2+)-ATPase complex with CrATP.
The Journal of biological chemistry 1992;267(5):3539-50.
1992: Andersen J P; Vilsen B; MacLennan D H
Functional consequences of alterations to Gly310, Gly770, and Gly801 located in the transmembrane domain of the Ca(2+)-ATPase of sarcoplasmic reticulum.
The Journal of biological chemistry 1992;267(4):2767-74.
1992: Vilsen B; Andersen J P; MacLennan D H
Mutational analysis of the role of Lys684 in the Ca(2+)-ATPase of sarcoplasmic reticulum.
Acta physiologica Scandinavica. Supplementum 1992;607():279-84.
1992: Andersen J P; Vilsen B
Structural basis for the E1/E1P-E2/E2P conformation changes in the sarcoplasmic reticulum Ca(2+)-ATPase studied by site-specific mutagenesis.
Acta physiologica Scandinavica. Supplementum 1992;607():151-9.
1991: Vilsen B; Andersen J P; MacLennan D H
Functional consequences of alterations to hydrophobic amino acids located at the M4S4 boundary of the Ca(2+)-ATPase of sarcoplasmic reticulum.
The Journal of biological chemistry 1991;266(28):18839-45.
1991: Vilsen B; Andersen J P; MacLennan D H
Functional consequences of alterations to amino acids located in the hinge domain of the Ca(2+)-ATPase of sarcoplasmic reticulum.
The Journal of biological chemistry 1991;266(24):16157-64.
1990: Andersen J P; Vilsen B
Primary ion pumps.
Current opinion in cell biology 1990;2(4):722-30.
1988: Andersen J P; Vilsen B
Radiation inactivation analysis of sarcoplasmic reticulum Ca-ATPase in membrane-bound form and in detergent-solubilized monomeric states.
FEBS letters 1988;234(1):120-6.
1988: Vilsen B; Andersen J P
Use of a small TSK GSW high-performance liquid chromatographic column for large-zone chromatographic studies of monomer-oligomer equilibria of membrane protein.
Journal of chromatography 1988;442():229-36.
1988: Vilsen B; Andersen J P
Ca2+ occlusion in monomeric sarcoplasmic reticulum Ca-ATPase.
Progress in clinical and biological research 1988;273():147-54.
1988: Vilsen B; Andersen J P; Petersen J; Jørgensen P L
Occlusion of 22Na+ and 86Rb+ in membrane-bound and soluble protomeric alpha beta-units of Na,K-ATPase.
Progress in clinical and biological research 1988;273():33-8.
1988: Andersen J P; Vilsen B
Overview: subunit interaction and conformational states. Ca-ATPase and Na,K-ATPase compared.
Progress in clinical and biological research 1988;268A():603-22.
1988: Vilsen B; Andersen J P; Petersen J; Jørgensen P L
Occlusion of 22Na+ and 86Rb+ in membrane-bound and soluble protomeric alpha beta-units of Na,K-ATPase.
Progress in clinical and biological research 1988;268A():383-90.
1987: Vilsen B; Andersen J P
Effect of phospholipid, detergent and protein-protein interaction on stability and phosphoenzyme isomerization of soluble sarcoplasmic reticulum Ca-ATPase.
European journal of biochemistry / FEBS 1987;170(1-2):421-9.
1987: Vilsen B; Andersen J P; Petersen J; Jørgensen P L
Occlusion of 22Na+ and 86Rb+ in membrane-bound and soluble protomeric alpha beta-units of Na,K-ATPase.
The Journal of biological chemistry 1987;262(22):10511-7.
1986: Andersen J P; Vilsen B; Collins J H; Jørgensen P L
Localization of E1-E2 conformational transitions of sarcoplasmic reticulum Ca-ATPase by tryptic cleavage and hydrophobic labeling.
The Journal of membrane biology 1986;93(1):85-92.

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