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Uwe Vinkemeier

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Christin Pelzel; Andreas Begitt; Nikola Wenta; Uwe Vinkemeier
Evidence against a Role for β-Arrestin1 in STAT1 Dephosphorylation and the Inhibition of Interferon-γ Signaling.
Nikola Wenta; Uwe Vinkemeier
Characterization of STAT self-association by analytical ultracentrifugation.
Andrew J Bonham; Leah M Osslund; Aaron J Prussin; Uwe Vinkemeier; Nikola Wenta; Norbert O Reich
STAT1:DNA sequence-dependent binding modulation by phosphorylation, protein:protein interactions and small-molecule inhibition.

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All Publications

2013: Christin Pelzel; Andreas Begitt; Nikola Wenta; Uwe Vinkemeier
Evidence against a Role for β-Arrestin1 in STAT1 Dephosphorylation and the Inhibition of Interferon-γ Signaling.
Molecular cell 2013;50(1):149-56.
2013: Nikola Wenta; Uwe Vinkemeier
Characterization of STAT self-association by analytical ultracentrifugation.
Methods in molecular biology (Clifton, N.J.) 2013;967():203-24.
2013: Andrew J Bonham; Leah M Osslund; Aaron J Prussin; Uwe Vinkemeier; Nikola Wenta; Norbert O Reich
STAT1:DNA sequence-dependent binding modulation by phosphorylation, protein:protein interactions and small-molecule inhibition.
Nucleic acids research 2013;41(2):754-63.
2011: Jasmin Speil; Roman Veith; Uwe Vinkemeier; Eugen Baumgart; Jan Peter Siebrasse; Ulrich Kubitscheck
Activated STAT1 transcription factors conduct distinct saltatory movements in the cell nucleus.
Biophysical journal 2011;101(11):2592-600.
2011: Andreas Begitt; Mathias Droescher; Klaus-Peter Knobeloch; Uwe Vinkemeier
SUMO conjugation of STAT1 protects cells from hyperresponsiveness to IFNγ.
Blood 2011;118(4):1002-7.
2011: Mathias Droescher; Andreas Begitt; Uwe Vinkemeier
Paracrystals of STAT proteins and their dissolution by SUMO: how reduced transcription factor solubility increases cytokine signaling.
Oncotarget 2011;2(7):527-8.
2011: Filipa Antunes; Andreas Marg; Uwe Vinkemeier
STAT1 signaling is not regulated by a phosphorylation-acetylation switch.
Molecular and cellular biology 2011;31(14):3029-37.
2011: Mathias Droescher; Andreas Begitt; Andreas Marg; Martin Zacharias; Uwe Vinkemeier
Cytokine-induced paracrystals prolong the activity of signal transducers and activators of transcription (STAT) and provide a model for the regulation of protein solubility by small ubiquitin-like modifier (SUMO).
The Journal of biological chemistry 2011;286(21):18731-46.
2010: Jonathan Nardozzi; Nikola Wenta; Noriko Yasuhara; Uwe Vinkemeier; Gino Cingolani
Molecular basis for the recognition of phosphorylated STAT1 by importin alpha5.
Journal of molecular biology 2010;402(1):83-100.
2010: Thomas Meyer; Uwe Vinkemeier
Assessing sequence-specific DNA binding and transcriptional activity of STAT1 transcription factor.
Methods in molecular biology (Clifton, N.J.) 2010;647():139-59.
2008: Andreas Marg; Thomas Meyer; Marc Vigneron; Uwe Vinkemeier
Microinjected antibodies interfere with protein nucleocytoplasmic shuttling by distinct molecular mechanisms.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2008;73A(12):1128-40.
2008: Nikola Wenta; Holger Strauss; Stefanie Meyer; Uwe Vinkemeier
Tyrosine phosphorylation regulates the partitioning of STAT1 between different dimer conformations.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(27):9238-43.
2008: Simone Spuler; Miriam Carl; Joanna Zabojszcza; Volker Straub; Kate Bushby; Steven A Moore; Sylvia Bähring; Katrin Wenzel; Uwe Vinkemeier; Christoph Rocken
Dysferlin-deficient muscular dystrophy features amyloidosis.
Annals of neurology 2008;63(3):323-8.
2007: Thomas Meyer; Uwe Vinkemeier
STAT nuclear translocation: potential for pharmacological intervention.
Expert opinion on therapeutic targets 2007;11(10):1355-65.
2007: Thomas Meyer; Andreas Begitt; Uwe Vinkemeier
Green fluorescent protein-tagging reduces the nucleocytoplasmic shuttling specifically of unphosphorylated STAT1.
The FEBS journal 2007;274(3):815-26.
2005: Inga Lödige; Andreas Marg; Burkhard Wiesner; Barbora Malecova; Thomas Oelgeschläger; Uwe Vinkemeier
Nuclear export determines the cytokine sensitivity of STAT transcription factors.
The Journal of biological chemistry 2005;280(52):43087-99.
2005: Uwe Vinkemeier; Thomas Meyer
Antiviral activity of oligomerization-deficient Stat1.
Genome informatics. International Conference on Genome Informatics 2005;16(1):44-8.
2004: Thomas Meyer; Uwe Vinkemeier
Nucleocytoplasmic shuttling of STAT transcription factors.
European journal of biochemistry / FEBS 2004;271(23-24):4606-12.
2004: Torsten Meissner; Eberhard Krause; Inga Lödige; Uwe Vinkemeier
Arginine methylation of STAT1: a reassessment.
Cell 2004;119(5):587-9; discussion 589-590.
2004: Uwe Vinkemeier
Getting the message across, STAT! Design principles of a molecular signaling circuit.
The Journal of cell biology 2004;167(2):197-201.
2004: Torsten Meissner; Eberhard Krause; Uwe Vinkemeier
Ratjadone and leptomycin B block CRM1-dependent nuclear export by identical mechanisms.
FEBS letters 2004;576(1-2):27-30.
2004: Andreas Marg; Ying Shan; Thomas Meyer; Torsten Meissner; Martin Brandenburg; Uwe Vinkemeier
Nucleocytoplasmic shuttling by nucleoporins Nup153 and Nup214 and CRM1-dependent nuclear export control the subcellular distribution of latent Stat1.
The Journal of cell biology 2004;165(6):823-33.
2004: Thomas Meyer; Lisa Hendry; Andreas Begitt; Susan John; Uwe Vinkemeier
A single residue modulates tyrosine dephosphorylation, oligomerization, and nuclear accumulation of stat transcription factors.
The Journal of biological chemistry 2004;279(18):18998-9007.
2003: Thomas Meyer; Andreas Marg; Petra Lemke; Burkhard Wiesner; Uwe Vinkemeier
DNA binding controls inactivation and nuclear accumulation of the transcription factor Stat1.
Genes & development 2003;17(16):1992-2005.
2003: Xiaomin Chen; Rashna Bhandari; Uwe Vinkemeier; Focco Van Den Akker; James E Darnell; John Kuriyan
A reinterpretation of the dimerization interface of the N-terminal domains of STATs.
Protein science : a publication of the Protein Society 2003;12(2):361-5.
2002: Thomas Meyer; Andreas Begitt; Inga Lödige; Marleen van Rossum; Uwe Vinkemeier
Constitutive and IFN-gamma-induced nuclear import of STAT1 proceed through independent pathways.
The EMBO journal 2002;21(3):344-54.
2002: Thomas Meyer; Karsten Gavenis; Uwe Vinkemeier
Cell type-specific and tyrosine phosphorylation-independent nuclear presence of STAT1 and STAT3.
Experimental cell research 2002;272(1):45-55.
2000: Andreas Begitt; Thomas Meyer; M van Rossum; Uwe Vinkemeier
Nucleocytoplasmic translocation of Stat1 is regulated by a leucine-rich export signal in the coiled-coil domain.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(19):10418-23.
1999: Susan John; Uwe Vinkemeier; E Soldaini; James E Darnell; Warren J Leonard
The significance of tetramerization in promoter recruitment by Stat5.
Molecular and cellular biology 1999;19(3):1910-8.
1998: Xiaomin Chen; Uwe Vinkemeier; Y Zhao; David Jeruzalmi; James E Darnell; John Kuriyan
Crystal structure of a tyrosine phosphorylated STAT-1 dimer bound to DNA.
Cell 1998;93(5):827-39.
1998: Uwe Vinkemeier; Ismail Moarefi; James E Darnell; John Kuriyan
Structure of the amino-terminal protein interaction domain of STAT-4.
Science (New York, N.Y.) 1998;279(5353):1048-52.
1996: J. Jue Zhang; Uwe Vinkemeier; W Gu; D Chakravarti; Curt M Horvath; James E Darnell
Two contact regions between Stat1 and CBP/p300 in interferon gamma signaling.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(26):15092-6.
1996: Uwe Vinkemeier; Steven Cohen; Ismail Moarefi; Brian T Chait; John Kuriyan; James E Darnell
DNA binding of in vitro activated Stat1 alpha, Stat1 beta and truncated Stat1: interaction between NH2-terminal domains stabilizes binding of two dimers to tandem DNA sites.
The EMBO journal 1996;15(20):5616-26.