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Shelia Violette

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Hui Geng; Annette Gilchrist; Rongpei Lan; Pothana Saikumar; Prajjal K Singha; Shelia M Violette; Joel M Weinberg; Paul H Weinreb; Manjeri Venkatachalam
Lysophosphatidic acid increases proximal tubule cell secretion of profibrotic cytokines PDGF-B and CTGF through LPA2- and Gαq-mediated Rho and αvβ6 integrin-dependent activation of TGF-β.
David S Garlick; Leeanne Griffith; Dario C Altieri; Julie Butterfield; Bridget Charbonneau; Tj Fitzgerald; Jing Li; Jane B Lian; Chun-Peng Liao; Timothy L Ratliff; Pradip Roy-Burman; Brian Sansoucy; Gary S Stein; Michele Vietri; Shelia M Violette; Tao Wang; Paul H Weinreb; Lucia R Languino
α(V)β(6) integrin expression is induced in the POET and Pten(pc-/-) mouse models of prostatic inflammation and prostatic adenocarcinoma.
Zea Borok; Harold A Chapman; Brigid L Hogan; Darrell N Kotton; Mark A Krasnow; Jonathan M Kurie; Edward E Morrisey; Steve L Nishimura; Paul W Noble; Derek C Radisky; Susan D Reynolds; Steve D Shapiro; Victor J Thannickal; Shelia M Violette; David C Walker; Jeffrey A Whitsett; Dorothy Gail; Diana W Bianchi; Peter B Bitterman; Carol J Blaisdell; James Kiley; Deborah Hoshizaki
Cell plasticity in lung injury and repair: report from an NHLBI workshop, April 19-20, 2010.

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All Publications

2012: Hui Geng; Annette Gilchrist; Rongpei Lan; Pothana Saikumar; Prajjal K Singha; Shelia M Violette; Joel M Weinberg; Paul H Weinreb; Manjeri Venkatachalam
Lysophosphatidic acid increases proximal tubule cell secretion of profibrotic cytokines PDGF-B and CTGF through LPA2- and Gαq-mediated Rho and αvβ6 integrin-dependent activation of TGF-β.
The American journal of pathology 2012;181(4):1236-49.
2012: David S Garlick; Leeanne Griffith; Dario C Altieri; Julie Butterfield; Bridget Charbonneau; Tj Fitzgerald; Jing Li; Jane B Lian; Chun-Peng Liao; Timothy L Ratliff; Pradip Roy-Burman; Brian Sansoucy; Gary S Stein; Michele Vietri; Shelia M Violette; Tao Wang; Paul H Weinreb; Lucia R Languino
α(V)β(6) integrin expression is induced in the POET and Pten(pc-/-) mouse models of prostatic inflammation and prostatic adenocarcinoma.
American journal of translational research 2012;4(2):165-74.
2011: Zea Borok; Harold A Chapman; Brigid L Hogan; Darrell N Kotton; Mark A Krasnow; Jonathan M Kurie; Edward E Morrisey; Steve L Nishimura; Paul W Noble; Derek C Radisky; Susan D Reynolds; Steve D Shapiro; Victor J Thannickal; Shelia M Violette; David C Walker; Jeffrey A Whitsett; Dorothy Gail; Diana W Bianchi; Peter B Bitterman; Carol J Blaisdell; James Kiley; Deborah Hoshizaki
Cell plasticity in lung injury and repair: report from an NHLBI workshop, April 19-20, 2010.
Proceedings of the American Thoracic Society 2011;8(3):215-22.
2011: Daniel Marsh; Krishna Suchak; Karwan A Moutasim; Sabarinath Vallath; Colin Hopper; Waseem Jerjes; Tahwinder Upile; Nicholas Kalavrezos; Shelia M Violette; Paul H Weinreb; Kerry A Chester; Jagdeep S Chana; John FRancis Marshall; Ian R Hart; Allan K Hackshaw; Kim Piper; Gareth J Thomas
Stromal features are predictive of disease mortality in oral cancer patients.
The Journal of pathology 2011;223(4):470-81.
2011: Karwan A Moutasim; Veronika Jenei; Karen Sapienza; Daniel Marsh; Paul H Weinreb; Shelia M Violette; Mark P Lewis; John FRancis Marshall; Farida Fortune; Waninayaka M Tilakaratne; Ian R Hart; Gareth J Thomas
Betel-derived alkaloid up-regulates keratinocyte alphavbeta6 integrin expression and promotes oral submucous fibrosis.
The Journal of pathology 2011;223(3):366-77.
2011: Tamiko R Katsumoto; Shelia M Violette; Dean Sheppard
Blocking TGFβ via Inhibition of the αvβ6 Integrin: A Possible Therapy for Systemic Sclerosis Interstitial Lung Disease.
International journal of rheumatology 2011;2011():208219.
2010: Bradley P Sullivan; Paul H Weinreb; Shelia M Violette; James P Luyendyk
The coagulation system contributes to alphaVbeta6 integrin expression and liver fibrosis induced by cholestasis.
The American journal of pathology 2010;177(6):2837-49.
2009: Varsha V Gupte; Suresh Ramasamy; Raghava Reddy; Jooeun Lee; Paul H Weinreb; Shelia M Violette; Andreas Guenther; David Warburton; Barbara Driscoll; Parviz Minoo; Saverio Bellusci
Overexpression of fibroblast growth factor-10 during both inflammatory and fibrotic phases attenuates bleomycin-induced pulmonary fibrosis in mice.
American journal of respiratory and critical care medicine 2009;180(5):424-36.
2009: Evan P Nadler; Danielle Patterson; Shelia M Violette; Paul H Weinreb; Michael Lewis; Margaret S Magid; M Alba Greco
Integrin alphavbeta6 and mediators of extracellular matrix deposition are up-regulated in experimental biliary atresia.
The Journal of surgical research 2009;154(1):21-9.
2009: Ming Yan Xu; Joanne Porte; Alan Knox; Paul H Weinreb; Toby M Maher; Shelia M Violette; Robin J McAnulty; Dean Sheppard; Gisli Jenkins
Lysophosphatidic acid induces alphavbeta6 integrin-mediated TGF-beta activation via the LPA2 receptor and the small G protein G alpha(q).
The American journal of pathology 2009;174(4):1264-79.
2009: Poshala Aluwihare; Zhenyu Mu; Zhicheng Zhao; Dawen Yu; Paul H Weinreb; Gerald S Horan; Shelia M Violette; John S Munger
Mice that lack activity of alphavbeta6- and alphavbeta8-integrins reproduce the abnormalities of Tgfb1- and Tgfb3-null mice.
Journal of cell science 2009;122(Pt 2):227-32.
2008: Jonathan L Hecht; Brian M Dolinski; Humphrey A Gardner; Shelia M Violette; Paul H Weinreb
Overexpression of the alphavbeta6 integrin in endometrial cancer.
Applied immunohistochemistry & molecular morphology : AIMM / official publication of the Society for Applied Immunohistochemistry 2008;16(6):543-7.
2008: Yuanlin Song; Jean-François Pittet; Xiaozhu Huang; Hong He; Susan V Lynch; Shelia M Violette; Paul H Weinreb; Gerald S Horan; Amua Carmago; Yoriko Sawa; Xin Liu Bernstein; jeanine wiener-kronish
Role of integrin alphav beta6 in acute lung injury induced by Pseudomonas aeruginosa.
Infection and immunity 2008;76(6):2325-32.
2008: Michael Ganter; Jérémie Roux; Byron Miyazawa; Marybeth Howard; James Frank; George Su; Dean Sheppard; Shelia M Violette; Paul H Weinreb; Gerald S Horan; Michael A Matthay; Jean-François Pittet
Interleukin-1beta causes acute lung injury via alphavbeta5 and alphavbeta6 integrin-dependent mechanisms.
Circulation research 2008;102(7):804-12.
2008: Louise A Koopman Van Aarsen; Diane R Leone; Steffan Ho; Brian M Dolinski; Patricia E McCoon; Doreen J Lepage; Rebecca Kelly; Glenna Heaney; Paul Rayhorn; Carl Reid; Kenneth J Simon; Gerald S Horan; Nianjun Tao; Humphrey A Gardner; Marilyn M Skelly; Allen M Gown; Gareth J Thomas; Paul H Weinreb; SE Fawell; Shelia M Violette
Antibody-mediated blockade of integrin alpha v beta 6 inhibits tumor progression in vivo by a transforming growth factor-beta-regulated mechanism.
Cancer research 2008;68(2):561-70.
2008: Gerald S Horan; Susan Wood; Victor Ona; Dan Jun Li; Matvey E Lukashev; Paul H Weinreb; Kenneth J Simon; Kyungmin Hahm; Normand E Allaire; Nicola J Rinaldi; Jaya Goyal; Carol A Feghali-Bostwick; Eric L Matteson; Carl O'Hara; Robert Lafyatis; Gerald S Davis; Xiaozhu Huang; Dean Sheppard; Shelia M Violette
Partial inhibition of integrin alpha(v)beta6 prevents pulmonary fibrosis without exacerbating inflammation.
American journal of respiratory and critical care medicine 2008;177(1):56-65.
2008: Khalid Puthawala; Nicos Hadjiangelis; Steven C Jacoby; Emmanuel Bayongan; Zhicheng Zhao; Zhiwei Yang; Mary Louise Devitt; Gerald S Horan; Paul H Weinreb; Matvey E Lukashev; Shelia M Violette; Kristen S Grant; Cristina Colarossi; Silvia C Formenti; John S Munger
Inhibition of integrin alpha(v)beta6, an activator of latent transforming growth factor-beta, prevents radiation-induced lung fibrosis.
American journal of respiratory and critical care medicine 2008;177(1):82-90.
2007: Bruce Wang; Brian M Dolinski; Noriko Kikuchi; Diane R Leone; Marion G Peters; Paul H Weinreb; Shelia M Violette; D Montgomery Bissell
Role of alphavbeta6 integrin in acute biliary fibrosis.
Hepatology (Baltimore, Md.) 2007;46(5):1404-12.
2007: Suzanne Hazelbag; Gemma G Kenter; Arko Gorter; Enno J Dreef; LA Koopman; Shelia M Violette; Paul H Weinreb; Gert Jan Fleuren
Overexpression of the alpha v beta 6 integrin in cervical squamous cell carcinoma is a prognostic factor for decreased survival.
The Journal of pathology 2007;212(3):316-24.
2007: Alan G Ramsay; Melanie D Keppler; Mona Jazayeri; Gareth J Thomas; Maddy Parsons; Shelia M Violette; Paul H Weinreb; Ian R Hart; John FRancis Marshall
HS1-associated protein X-1 regulates carcinoma cell migration and invasion via clathrin-mediated endocytosis of integrin alphavbeta6.
Cancer research 2007;67(11):5275-84.
2007: Janeen Azare; Kenneth Leslie; Hikmat Al-Ahmadie; William Gerald; Paul H Weinreb; Shelia M Violette; Jacqueline F Bromberg
Constitutively activated Stat3 induces tumorigenesis and enhances cell motility of prostate epithelial cells through integrin beta 6.
Molecular and cellular biology 2007;27(12):4444-53.
2007: Danielle DiCara; Chiara Rapisarda; Julie L Sutcliffe; Shelia M Violette; Paul H Weinreb; Ian R Hart; Mark J Howard; John FRancis Marshall
Structure-function analysis of Arg-Gly-Asp helix motifs in alpha v beta 6 integrin ligands.
The Journal of biological chemistry 2007;282(13):9657-65.
2007: Saldanha Rohit; Mark P Molloy; Khalil Bdeir; Douglas B Cines; Xiaomin Song; Pauliina M Uitto; Paul H Weinreb; Shelia M Violette; Mark Baker
Proteomic identification of lynchpin urokinase plasminogen activator receptor protein interactions associated with epithelial cancer malignancy.
Journal of proteome research 2007;6(3):1016-28.
2007: Kyungmin Hahm; Matvey E Lukashev; Yi Luo; William J Yang; Brian M Dolinski; Paul H Weinreb; Kenneth J Simon; Li Chun Wang; Diane R Leone; Roy R Lobb; Donald J McCrann; Normand E Allaire; Gerald S Horan; Agnes Fogo; Raghu Kalluri; Charles F Shield; Dean Sheppard; Humphrey A Gardner; Shelia M Violette
Alphav beta6 integrin regulates renal fibrosis and inflammation in Alport mouse.
The American journal of pathology 2007;170(1):110-25.
2006: Maria L Nystrom; Diana McCulloch; Paul H Weinreb; Shelia M Violette; Paul M Speight; John FRancis Marshall; Ian R Hart; Gareth J Thomas
Cyclooxygenase-2 inhibition suppresses alphavbeta6 integrin-dependent oral squamous carcinoma invasion.
Cancer research 2006;66(22):10833-42.
2005: Paul Monaghan; Sarah Gold; Jennifer Simpson; Zhidong Zhang; Paul H Weinreb; Shelia M Violette; Soren Alexandersen; Terry Jackson
The alpha(v)beta6 integrin receptor for Foot-and-mouth disease virus is expressed constitutively on the epithelial cells targeted in cattle.
The Journal of general virology 2005;86(Pt 10):2769-80.
2005: Audrey E K Hutcheon; Xiaoqing Q Guo; Mary Ann Stepp; Kenneth J Simon; Paul H Weinreb; Shelia M Violette; James D Zieske
Effect of wound type on Smad 2 and 4 translocation.
Investigative ophthalmology & visual science 2005;46(7):2362-8.
2004: Paul H Weinreb; Kenneth J Simon; Paul Rayhorn; William J Yang; Diane R Leone; Brian M Dolinski; Bradley R Pearse; Yukako Yokota; Hisaaki Kawakatsu; Amha Atakilit; Dean Sheppard; Shelia M Violette
Function-blocking integrin alphavbeta6 monoclonal antibodies: distinct ligand-mimetic and nonligand-mimetic classes.
The Journal of biological chemistry 2004;279(17):17875-87.
2003: Chi B Vu; George P Luke; Noriyuki Kawahata; William C Shakespeare; Yihan Wang; Raji Sundaramoorthi; Chester A Metcalf; Terence P Keenan; Selvi Pradeepan; Evelyn Corpuz; Taylor Merry; Regine S Bohacek; David C Dalgarno; Surinder S Narula; Marie Rose van Schravendijk; Mary Ram; Susan Adams; Shuenn Liou; Jeffrey A Keats; Shelia M Violette; Wei Guan; Manfred Weigele; Tomi K Sawyer
Bone-targeted pyrido[2,3-d]pyrimidin-7-ones: potent inhibitors of Src tyrosine kinase as novel antiresorptive agents.
Bioorganic & medicinal chemistry letters 2003;13(18):3071-4.
2003: Yihan Wang; Chester A Metcalf; William C Shakespeare; Raji Sundaramoorthi; Terence P Keenan; Regine S Bohacek; Marie Rose van Schravendijk; Shelia M Violette; Surinder S Narula; David C Dalgarno; Chad Haraldson; Jeffrey A Keats; Shuenn Liou; Ukti N. Mani; Selvi Pradeepan; Mary Ram; Susan Adams; Manfred Weigele; Tomi K Sawyer
Bone-targeted 2,6,9-trisubstituted purines: novel inhibitors of Src tyrosine kinase for the treatment of bone diseases.
Bioorganic & medicinal chemistry letters 2003;13(18):3067-70.
2003: Raji Sundaramoorthi; William C Shakespeare; Terence P Keenan; Chester A Metcalf; Yihan Wang; Ukti N. Mani; Merry Taylor; Shuangying Liu; Regine S Bohacek; Surinder S Narula; David C Dalgarno; Marie Rose van Schravandijk; Shelia M Violette; Shuenn Liou; Susan Adams; Mary Ram; Jeffrey A Keats; Manfred Weigle; Tomi K Sawyer; Manfred Weigele
Bone-targeted Src kinase inhibitors: novel pyrrolo- and pyrazolopyrimidine analogues.
Bioorganic & medicinal chemistry letters 2003;13(18):3063-6.
2002: Paul H Weinreb; William J Yang; Shelia M Violette; Megan Couture; Kathleen Kimball; R Blake Pepinsky; Roy R Lobb; Serene Josiah
A cell-free electrochemiluminescence assay for measuring beta1-integrin-ligand interactions.
Analytical biochemistry 2002;306(2):305-13.
2001: Noriyuki Kawahata; Michael G Yang; George P Luke; William C Shakespeare; Raji Sundaramoorthi; Yihan Wang; D Johnson; Taylor Merry; Shelia M Violette; Wei Guan; C Bartlett; J Smith; MH Hatada; X Lu; David C Dalgarno; Charles J Eyermann; Regine S Bohacek; Tomi K Sawyer
A novel phosphotyrosine mimetic 4'-carboxymethyloxy-3'-phosphonophenylalanine (Cpp): exploitation in the design of nonpeptide inhibitors of pp60(Src) SH2 domain.
Bioorganic & medicinal chemistry letters 2001;11(17):2319-23.
2001: Regine S Bohacek; David C Dalgarno; MH Hatada; V A Jacobsen; Berkley Lynch; KJ Macek; Taylor Merry; Chester A Metcalf; Surinder S Narula; Tomi K Sawyer; William C Shakespeare; Shelia M Violette; Manfred Weigele
X-Ray structure of citrate bound to Src SH2 leads to a high-affinity, bone-targeted Src SH2 inhibitor.
Journal of medicinal chemistry 2001;44(5):660-3.
2001: Shelia M Violette; Wei Guan; C Bartlett; J A Smith; C Bardelay; E Antoine; RJ Rickles; Eliane Mandine; Marie Rose van Schravendijk; SE Adams; Berkley Lynch; William C Shakespeare; M Yang; V A Jacobsen; C S Takeuchi; KJ Macek; Regine S Bohacek; David C Dalgarno; Manfred Weigele; Dominique Lesuisse; Tomi K Sawyer; R Baron
Bone-targeted Src SH2 inhibitors block Src cellular activity and osteoclast-mediated resorption.
Bone 2001;28(1):54-64.
2000: William C Shakespeare; Regine S Bohacek; MD Azimioara; KJ Macek; George P Luke; David C Dalgarno; MH Hatada; X Lu; Shelia M Violette; C Bartlett; Tomi K Sawyer
Structure-based design of novel bicyclic nonpeptide inhibitors for the src SH2 domain.
Journal of medicinal chemistry 2000;43(21):3815-9.
2000: William C Shakespeare; M Yang; Regine S Bohacek; frank cerasoli; K Stebbins; Raji Sundaramoorthi; MD Azimioara; Chi B Vu; Selvi Pradeepan; Chester A Metcalf; Chad Haraldson; Taylor Merry; David C Dalgarno; Surinder S Narula; MH Hatada; X Lu; Marie Rose van Schravendijk; Susan Adams; Shelia M Violette; J Smith; Wei Guan; C Bartlett; J Herson; John D Iuliucci; Manfred Weigele; Tomi Sawyer
Structure-based design of an osteoclast-selective, nonpeptide src homology 2 inhibitor with in vivo antiresorptive activity.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(17):9373-8.
2000: Chester A Metcalf; Charles J Eyermann; Regine S Bohacek; Chad Haraldson; Vaibhav VARKHEDKAR; Berkley Lynch; C Bartlett; Shelia M Violette; Tomi K Sawyer
Structure-based design and solid-phase parallel synthesis of phosphorylated nonpeptides to explore hydrophobic binding at the Src SH2 domain.
Journal of combinatorial chemistry 2000;2(4):305-13.
2000: Shelia M Violette; William C Shakespeare; C Bartlett; Wei Guan; J A Smith; RJ Rickles; Regine S Bohacek; Dennis A Holt; R Baron; Tomi K Sawyer
A Src SH2 selective binding compound inhibits osteoclast-mediated resorption.
Chemistry & biology 2000;7(3):225-35.
1999: Chi B Vu; Evelyn Corpuz; Selvi Pradeepan; Shelia M Violette; C Bartlett; Tomi K Sawyer
Nonpeptidic SH2 inhibitors of the tyrosine kinase ZAP-70.
Bioorganic & medicinal chemistry letters 1999;9(20):3009-14.
1999: Chi B Vu; Evelyn Corpuz; Taylor Merry; Selvi Pradeepan; C Bartlett; Regine S Bohacek; MC Botfield; Charles J Eyermann; Berkley Lynch; Ian A MacNeil; Mary Ram; Marie Rose van Schravendijk; Shelia M Violette; Tomi K Sawyer
Discovery of potent and selective SH2 inhibitors of the tyrosine kinase ZAP-70.
Journal of medicinal chemistry 1999;42(20):4088-98.
1998: RJ Rickles; P A Henry; Wei Guan; MD Azimioara; William C Shakespeare; Shelia M Violette; M J Zoller
A novel mechanism-based mammalian cell assay for the identification of SH2-domain-specific protein-protein inhibitors.
Chemistry & biology 1998;5(10):529-38.