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David Virley

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Charlotte K Callaghan; Andrea Della-Chiesa; Vincent Hok; Neil Upton; David J Virley; Shane O'Mara
Age-related declines in delayed non-match-to-sample performance (DNMS) are reversed by the novel 5HT6 receptor antagonist SB742457.
Boon Wan Wang; Marian Tsanov; Neil Upton; David J Virley; Sally Barlow; Ranya Bechara; Charlotte Callaghan; Andrea Della-Chiesa; Vincent Hok; Elaine Irving; Shane O'Mara
Rosiglitazone enhances learning, place cell activity, and synaptic plasticity in middle-aged rats.
Kerry A Waters; Beverley Hammond; James N C Kew; Tania O Stean; Neil Upton; David J Virley; Ishrut Hussain
Effects of the selective 5-HT(7) receptor antagonist SB-269970 in animal models of psychosis and cognition.

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All Publications

2012: Charlotte K Callaghan; Andrea Della-Chiesa; Vincent Hok; Neil Upton; David J Virley; Shane O'Mara
Age-related declines in delayed non-match-to-sample performance (DNMS) are reversed by the novel 5HT6 receptor antagonist SB742457.
Neuropharmacology 2012;63(5):890-7.
2012: Boon Wan Wang; Marian Tsanov; Neil Upton; David J Virley; Sally Barlow; Ranya Bechara; Charlotte Callaghan; Andrea Della-Chiesa; Vincent Hok; Elaine Irving; Shane O'Mara
Rosiglitazone enhances learning, place cell activity, and synaptic plasticity in middle-aged rats.
Neurobiology of aging 2012;33(4):835.e13-30.
2012: Kerry A Waters; Beverley Hammond; James N C Kew; Tania O Stean; Neil Upton; David J Virley; Ishrut Hussain
Effects of the selective 5-HT(7) receptor antagonist SB-269970 in animal models of psychosis and cognition.
Behavioural brain research 2012;228(1):211-8.
2012: Tomas Ondrejcak; Roger Anwyl; James N C Kew; Neil Upton; David J Virley; Qinwen Wang; Michael J Rowan
Activation of α7 nicotinic acetylcholine receptors persistently enhances hippocampal synaptic transmission and prevents Aß-mediated inhibition of LTP in the rat hippocampus.
European journal of pharmacology 2012;677(1-3):63-70.
2011: Mairi Sime; Timothy M Wilson; Robert X Xu; Timothy M Willson; Amanda C Allan; Paul Chapman; Charlotte Fieldhouse; Gerard M P Giblin; Mark P Healy; Millard H Lambert; Lisa M Leesnitzer; Ann Lewis; Raymond V Merrihew; Richard A Rutter; Rosemary Sasse; Barry G Shearer; David J Virley
Discovery of GSK1997132B a novel centrally penetrant benzimidazole PPARγ partial agonist.
Bioorganic & medicinal chemistry letters 2011;21(18):5568-72.
2010: Joern E Schroeder; Jill C Richardson; David J Virley
Dietary manipulation and caloric restriction in the development of mouse models relevant to neurological diseases.
Biochimica et biophysica acta 2010;1802(10):840-6.
2008: Neil Upton; Tsu Tshen Chuang; Ann J Hunter; David J Virley
5-HT6 receptor antagonists as novel cognitive enhancing agents for Alzheimer's disease.
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2008;5(3):458-69.
2008: K A Stockwell; David J Virley; M Perren; mahmoud iravani; Michael J Jackson; Sarah Rose; Peter Jenner
Continuous delivery of ropinirole reverses motor deficits without dyskinesia induction in MPTP-treated common marmosets.
Experimental neurology 2008;211(1):172-9.
2007: leann quinn; Marion J Perren; Kim T Brackenborough; Peter L Woodhams; Martin Vidgeon-Hart; Helen Chapman; Menelas Pangalos; Neil Upton; David J Virley
A beam-walking apparatus to assess behavioural impairments in MPTP-treated mice: pharmacological validation with R-(-)-deprenyl.
Journal of neuroscience methods 2007;164(1):43-9.
2007: Anthony J Strong; Peter J Anderson; Helena R Watts; David J Virley; Andrew Lloyd; Elaine A Irving; Toshiaki Nagafuji; Mitsuyoshi Ninomiya; Hajime Nakamura; Andrew K Dunn; Rudolf Graf
Peri-infarct depolarizations lead to loss of perfusion in ischaemic gyrencephalic cerebral cortex.
Brain : a journal of neurology 2007;130(Pt 4):995-1008.
2007: Jay C Strum; Ron Shehee; David J Virley; Jill Richardson; Michael Mattie; Paula Selley; Sujoy Ghosh; Christina Nock; Ann M Saunders; Allen D Roses
Rosiglitazone induces mitochondrial biogenesis in mouse brain.
Journal of Alzheimer's disease : JAD 2007;11(1):45-51.
2007: Perdita L Pugh; Martin Vidgeon-Hart; Tracey E Ashmeade; Ainsley A Culbert; Zoe Seymour; Marion J Perren; Flora Joyce; Simon T Bate; Anna Babin; David J Virley; Jill C Richardson; Neil Upton; David Sunter
Repeated administration of the noradrenergic neurotoxin N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP-4) modulates neuroinflammation and amyloid plaque load in mice bearing amyloid precursor protein and presenilin-1 mutant transgenes.
Journal of neuroinflammation 2007;4():8.
2006: leann quinn; Tania O Stean; Helen Chapman; Matthew Brown; Martin Vidgeon-Hart; Neil Upton; Andrew Billinton; David J Virley
Further validation of LABORAS using various dopaminergic manipulations in mice including MPTP-induced nigro-striatal degeneration.
Journal of neuroscience methods 2006;156(1-2):218-27.
2005: David J Virley
Developing therapeutics for the treatment of multiple sclerosis.
NeuroRx : the journal of the American Society for Experimental NeuroTherapeutics 2005;2(4):638-49.
2005: Elaine A Irving; Mary Vinson; Claudia Rosin; Jenny C Roberts; Debra M Chapman; Laura Facci; David J Virley; Stephen Skaper; Stephen A Burbidge; Frank S Walsh; A Jackie Hunter; Andrew A Parsons
Identification of neuroprotective properties of anti-MAG antibody: a novel approach for the treatment of stroke?
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2005;25(1):98-107.
2005: David J Virley
Choice, methodology, and characterization of focal ischemic stroke models: the search for clinical relevance.
Methods in molecular medicine 2005;104():19-48.
2004: Mark E P Hows; Tracey E Ashmeade; Andrew Billinton; Marion J Perren; Angela A Austin; David J Virley; Andrew J Organ; Ajit J Shah
High-performance liquid chromatography/tandem mass spectrometry assay for the determination of 1-methyl-4-phenyl pyridinium (MPP+) in brain tissue homogenates.
Journal of neuroscience methods 2004;137(2):221-6.
2004: Paul Preece; David J Virley; Moheb Costandi; Robert Coombes; Stephen J Moss; Anne W Mudge; Elena Jazin; Nigel J Cairns
Amyloid precursor protein mRNA levels in Alzheimer's disease brain.
Brain research. Molecular brain research 2004;122(1):1-9.
2004: David J Virley; Sarah J Hadingham; Jenny C Roberts; Belinda Farnfield; Heather Elliott; Greg Whelan; Jackie Golder; Chris David; Andrew A Parsons; A Jackie Hunter
A new primate model of focal stroke: endothelin-1-induced middle cerebral artery occlusion and reperfusion in the common marmoset.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2004;24(1):24-41.
2003: Michel Modo; K Hopkins; David J Virley; Helen Hodges
Transplantation of neural stem cells modulates apolipoprotein E expression in a rat model of stroke.
Experimental neurology 2003;183(2):320-9.
2003: Paul Preece; David J Virley; Moheb Costandi; Robert Coombes; Stephen J Moss; Anne W Mudge; Elena Jazin; Nigel J Cairns
Beta-secretase (BACE) and GSK-3 mRNA levels in Alzheimer's disease.
Brain research. Molecular brain research 2003;116(1-2):155-8.
2003: Paul Preece; David J Virley; Moheb Costandi; Robert Coombes; Stephen J Moss; Anne W Mudge; Elena Jazin; Nigel J Cairns
An optimistic view for quantifying mRNA in post-mortem human brain.
Brain research. Molecular brain research 2003;116(1-2):7-16.
2002: Brian C Bond; David J Virley; Nigel J Cairns; A Jackie Hunter; Gary B T Moore; Stephen J Moss; Anne W Mudge; Frank S Walsh; Elena Jazin; Paul Preece
The quantification of gene expression in an animal model of brain ischaemia using TaqMan real-time RT-PCR.
Brain research. Molecular brain research 2002;106(1-2):101-16.
2002: Jonathan P Hatcher; David J Virley; Sarah J Hadingham; J Roberts; A Jackie Hunter; Andrew A Parsons
The behavioural effect of middle cerebral artery occlusion on apolipoprotein-E deficient mice.
Behavioural brain research 2002;131(1-2):139-49.
2000: A Jackie Hunter; Jonathan P Hatcher; David J Virley; P Nelson; Elaine A Irving; Sarah J Hadingham; Andrew A Parsons
Functional assessments in mice and rats after focal stroke.
Neuropharmacology 2000;39(5):806-16.
2000: Jeffrey A Gray; GA Grigoryan; David J Virley; Sara Patel; John Sinden; Helen Hodges
Conditionally immortalized, multipotential and multifunctional neural stem cell lines as an approach to clinical transplantation.
Cell transplantation 2000;9(2):153-68.
2000: David J Virley; J S Beech; S C Smart; S C Williams; Helen Hodges; A Jackie Hunter
A temporal MRI assessment of neuropathology after transient middle cerebral artery occlusion in the rat: correlations with behavior.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2000;20(3):563-82.
2000: Helen Hodges; P Sowinski; David J Virley; A Nelson; TR Kershaw; W P Watson; T Veizovic; Sara Patel; A Mora; Taha Rashid; SJ French; A Chadwick; Jeffrey A Gray; John Sinden
Functional reconstruction of the hippocampus: fetal versus conditionally immortal neuroepithelial stem cell grafts.
Novartis Foundation symposium 2000;231():53-65; discussion 65-9.
1999: David J Virley; Rosalind M Ridley; John Sinden; TR Kershaw; S Harland; Taha Rashid; S French; P Sowinski; Jeffrey A Gray; P L Lantos; Helen Hodges
Primary CA1 and conditionally immortal MHP36 cell grafts restore conditional discrimination learning and recall in marmosets after excitotoxic lesions of the hippocampal CA1 field.
Brain : a journal of neurology 1999;122 ( Pt 12)():2321-35.
1997: Helen Hodges; A Nelson; David J Virley; TR Kershaw; John Sinden
Cognitive deficits induced by global cerebral ischaemia: prospects for transplant therapy.
Pharmacology, biochemistry, and behavior 1997;56(4):763-80.