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David Boyle

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Anatomy

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TOP 3
Kazuhisa Nakano; David L Boyle; Gary S Firestein
Regulation of DNA methylation in rheumatoid arthritis synoviocytes.
Kazuhisa Nakano; Wei Wang; John W Whitaker; David L Boyle; Gary S Firestein
DNA methylome signature in rheumatoid arthritis.
Monica Guma; Deepa Hammaker; Michael Karin; Katharyn Topolewski; David L Boyle; Maripat Corr; Gary S Firestein
Antiinflammatory functions of p38 in mouse models of rheumatoid arthritis: advantages of targeting upstream kinases MKK-3 or MKK-6.

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All Publications

2013: Kazuhisa Nakano; David L Boyle; Gary S Firestein
Regulation of DNA methylation in rheumatoid arthritis synoviocytes.
Journal of immunology (Baltimore, Md. : 1950) 2013;190(3):1297-303.
2013: Kazuhisa Nakano; Wei Wang; John W Whitaker; David L Boyle; Gary S Firestein
DNA methylome signature in rheumatoid arthritis.
Annals of the rheumatic diseases 2013;72(1):110-7.
2012: Monica Guma; Deepa Hammaker; Michael Karin; Katharyn Topolewski; David L Boyle; Maripat Corr; Gary S Firestein
Antiinflammatory functions of p38 in mouse models of rheumatoid arthritis: advantages of targeting upstream kinases MKK-3 or MKK-6.
Arthritis and rheumatism 2012;64(9):2887-95.
2012: Beatrix Bartok; David L Boyle; William D Bugbee; Yi Liu; Pingda Ren; Christian Rommel; Scott T Ball; Gary S Firestein
PI3 kinase δ is a key regulator of synoviocyte function in rheumatoid arthritis.
The American journal of pathology 2012;180(5):1906-16.
2012: Deepa Hammaker; David L Boyle; Gary S Firestein
Synoviocyte innate immune responses: TANK-binding kinase-1 as a potential therapeutic target in rheumatoid arthritis.
Rheumatology (Oxford, England) 2012;51(4):610-8.
2012: Sanna Rosengren; Maripat Corr; Gary S Firestein; David L Boyle
The JAK inhibitor CP-690,550 (tofacitinib) inhibits TNF-induced chemokine expression in fibroblast-like synoviocytes: autocrine role of type I interferon.
Annals of the rheumatic diseases 2012;71(3):440-7.
2012: Deepa Hammaker; Robert L Sah; Katharyn Topolewski; Toshio Yoshizawa; David L Boyle; Esther Cory Burak; Meghan Edgar; Akihisa Fukushima; Gary S Firestein
Decreased collagen-induced arthritis severity and adaptive immunity in MKK-6-deficient mice.
Arthritis and rheumatism 2012;64(3):678-87.
2012: Sang-il Lee; Andres Berdeja; David L Boyle; Gary S Firestein
Regulation of inflammatory arthritis by the upstream kinase mitogen activated protein kinase kinase 7 in the c-Jun N-terminal kinase pathway.
Arthritis research & therapy 2012;14(1):R38.
2011: Sanna Rosengren; Kenneth C Kalunian; Arthur Kavanaugh; David L Boyle
CXCL13 as a marker for outcome of rheumatoid arthritis: comment on the article by Meeuwisse et al.
Arthritis and rheumatism 2011;63(11):3646-7.
2011: Yubin Luo; David L Boyle; Meghan Edgar; Guido Franzoso; Deepa Hammaker; Gary S Firestein
Suppression of collagen-induced arthritis in growth arrest and DNA damage-inducible protein 45β-deficient mice.
Arthritis and rheumatism 2011;63(10):2949-55.
2011: Maripat Corr; David L Boyle; Lisa M Ronacher; Brian R Lew; Lisa G van Baarsen; Paul P Tak; Gary S Firestein
Interleukin 1 receptor antagonist mediates the beneficial effects of systemic interferon beta in mice: implications for rheumatoid arthritis.
Annals of the rheumatic diseases 2011;70(5):858-63.
2011: Sanna Rosengren; Nathan Wei; Kenneth C Kalunian; Arthur Kavanaugh; David L Boyle
CXCL13: a novel biomarker of B-cell return following rituximab treatment and synovitis in patients with rheumatoid arthritis.
Rheumatology (Oxford, England) 2011;50(3):603-10.
2010: Sanna Rosengren; Maripat Corr; David L Boyle
Platelet-derived growth factor and transforming growth factor beta synergistically potentiate inflammatory mediator synthesis by fibroblast-like synoviocytes.
Arthritis research & therapy 2010;12(2):R65.
2009: Camilla I Svensson; Tomoyuki Inoue; Deepa Hammaker; Akihisa Fukushima; Salvatore Papa; Guido Franzoso; Georg Schett; Maripat Corr; David L Boyle; Gary S Firestein
Gadd45beta deficiency in rheumatoid arthritis: enhanced synovitis through JNK signaling.
Arthritis and rheumatism 2009;60(11):3229-40.
2009: K L Herbst; A D Coviello; A Chang; David L Boyle
Lipomatosis-associated inflammation and excess collagen may contribute to lower relative resting energy expenditure in women with adiposis dolorosa.
International journal of obesity (2005) 2009;33(9):1031-8.
2009: Linda S Sorkin; David L Boyle; Deepa Hammaker; D S Herman; E Vail; Gary S Firestein
MKK3, an upstream activator of p38, contributes to formalin phase 2 and late allodynia in mice.
Neuroscience 2009;162(2):462-71.
2009: Yifang Chen; Sahil Khanna; Carl S Goodyear; Yong Beom Park; Eyal Raz; Steffen Thiel; Caroline Grönwall; Jaya Vas; David L Boyle; Maripat Corr; Dwight H Kono; Gregg J Silverman
Regulation of dendritic cells and macrophages by an anti-apoptotic cell natural antibody that suppresses TLR responses and inhibits inflammatory arthritis.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(2):1346-59.
2009: Toshio Yoshizawa; Deepa Hammaker; David L Boyle; Maripat Corr; Richard Flavell; Roger Davis; Georg Schett; Gary S Firestein
Role of MAPK kinase 6 in arthritis: distinct mechanism of action in inflammation and cytokine expression.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(2):1360-7.
2009: Susannah D Brydges; James L Mueller; Matthew D McGeough; Carla A Pena; Amirhossein Misaghi; Chhavi Gandhi; Chris D Putnam; David L Boyle; Gary S Firestein; Anthony A Horner; pejman Soroosh; Wendy T Watford; John O'Shea; Daniel Kastner; Hal M Hoffman
Inflammasome-mediated disease animal models reveal roles for innate but not adaptive immunity.
Immunity 2009;30(6):875-87.
2009: Maripat Corr; David L Boyle; L Ronacher; N Flores; Gary S Firestein
Synergistic benefit in inflammatory arthritis by targeting I kappaB kinase epsilon and interferon beta.
Annals of the rheumatic diseases 2009;68(2):257-63.
2008: jean-marc waldburger; David L Boyle; Valentin A Pavlov; Kevin Tracey; Gary S Firestein
Acetylcholine regulation of synoviocyte cytokine expression by the alpha7 nicotinic receptor.
Arthritis and rheumatism 2008;58(11):3439-49.
2008: jean-marc waldburger; David L Boyle; Meghan Edgar; Linda S Sorkin; Yaakov A Levine; Valentin A Pavlov; Kevin Tracey; Gary S Firestein
Spinal p38 MAP kinase regulates peripheral cholinergic outflow.
Arthritis and rheumatism 2008;58(9):2919-21.
2008: Toshio Yoshizawa; Deepa Hammaker; Susan E Sweeney; David L Boyle; Gary S Firestein
Synoviocyte innate immune responses: I. Differential regulation of interferon responses and the JNK pathway by MAPK kinases.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(5):3252-8.
2008: David L Boyle; Arthur Kavanaugh
The pathobiology of psoriatic synovium.
Current opinion in rheumatology 2008;20(4):404-7.
2008: Wai W Cheung; Sanna Rosengren; David L Boyle; Robert H Mak
Modulation of melanocortin signaling ameliorates uremic cachexia.
Kidney international 2008;74(2):180-6.
2008: Gregg J Silverman; David L Boyle
Understanding the mechanistic basis in rheumatoid arthritis for clinical response to anti-CD20 therapy: the B-cell roadblock hypothesis.
Immunological reviews 2008;223():175-85.
2008: Arthur Kavanaugh; Sanna Rosengren; S J Lee; Deepa Hammaker; Gary S Firestein; Kenneth C Kalunian; N Wei; David L Boyle
Assessment of rituximab's immunomodulatory synovial effects (ARISE trial). 1: clinical and synovial biomarker results.
Annals of the rheumatic diseases 2008;67(3):402-8.
2008: Sanna Rosengren; Nathan Wei; Kenneth C Kalunian; Nathan J Zvaifler; Arthur Kavanaugh; David L Boyle
Elevated autoantibody content in rheumatoid arthritis synovia with lymphoid aggregates and the effect of rituximab.
Arthritis research & therapy 2008;10(5):R105.
2007: Sanna Rosengren; James L Mueller; Justin P Anderson; Brian L Niehaus; Amirhossein Misaghi; Scott Anderson; David L Boyle; Hal M Hoffman
Monocytes from familial cold autoinflammatory syndrome patients are activated by mild hypothermia.
The Journal of allergy and clinical immunology 2007;119(4):991-6.
2007: Danielle M Gerlag; David L Boyle; Sanna Rosengren; Tony Nash; Paul P Tak; Gary S Firestein
Real-time quantitative PCR to detect changes in synovial gene expression in rheumatoid arthritis after corticosteroid treatment.
Annals of the rheumatic diseases 2007;66(4):545-7.
2007: Carl S Goodyear; Maripat Corr; Fujimi Sugiyama; David L Boyle; Gregg J Silverman
Cutting Edge: Bim is required for superantigen-mediated B cell death.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(5):2636-40.
2007: Sanna Rosengren; David L Boyle; Gary S Firestein
Acquisition, culture, and phenotyping of synovial fibroblasts.
Methods in molecular medicine 2007;135():365-75.
2007: Deepa Hammaker; David L Boyle; Tomoyuki Inoue; Gary S Firestein
Regulation of the JNK pathway by TGF-beta activated kinase 1 in rheumatoid arthritis synoviocytes.
Arthritis research & therapy 2007;9(3):R57.
2006: David L Boyle; Toni L Jones; Deepa Hammaker; Camille I Svensson; Sanna Rosengren; Salvatore Albani; Linda S Sorkin; Gary S Firestein
Regulation of peripheral inflammation by spinal p38 MAP kinase in rats.
PLoS medicine 2006;3(9):e338.
2006: Tomoyuki Inoue; Deepa Hammaker; David L Boyle; Gary S Firestein
Regulation of JNK by MKK-7 in fibroblast-like synoviocytes.
Arthritis and rheumatism 2006;54(7):2127-35.
2006: Hoon-Suk Cha; David L Boyle; Tomoyuki Inoue; Reineke Schoot; Paul P Tak; Polly Pine; Gary S Firestein
A novel spleen tyrosine kinase inhibitor blocks c-Jun N-terminal kinase-mediated gene expression in synoviocytes.
The Journal of pharmacology and experimental therapeutics 2006;317(2):571-8.
2006: Tomoyuki Inoue; David L Boyle; Maripat Corr; Deepa Hammaker; Roger J Davis; Richard A Flavell; Gary S Firestein
Mitogen-activated protein kinase kinase 3 is a pivotal pathway regulating p38 activation in inflammatory arthritis.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(14):5484-9.
2006: Hoon-Suk Cha; Sanna Rosengren; David L Boyle; Gary S Firestein
PUMA regulation and proapoptotic effects in fibroblast-like synoviocytes.
Arthritis and rheumatism 2006;54(2):587-92.
2006: Xin You; David L Boyle; Deepa Hammaker; Gary S Firestein
PUMA-mediated apoptosis in fibroblast-like synoviocytes does not require p53.
Arthritis research & therapy 2006;8(6):R157.
2005: Egle Simelyte; Sanna Rosengren; David L Boyle; Maripat Corr; Douglas R Green; Gary S Firestein
Regulation of arthritis by p53: critical role of adaptive immunity.
Arthritis and rheumatism 2005;52(6):1876-84.
2005: Susan E Sweeney; Deepa Hammaker; David L Boyle; Gary S Firestein
Regulation of c-Jun phosphorylation by the I kappa B kinase-epsilon complex in fibroblast-like synoviocytes.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(10):6424-30.
2005: Sanna Rosengren; Hal M Hoffman; William Bugbee; David L Boyle
Expression and regulation of cryopyrin and related proteins in rheumatoid arthritis synovium.
Annals of the rheumatic diseases 2005;64(5):708-14.
2005: Tomoyuki Inoue; Deepa Hammaker; David L Boyle; Gary S Firestein
Regulation of p38 MAPK by MAPK kinases 3 and 6 in fibroblast-like synoviocytes.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(7):4301-6.
2005: Junko Ohata; Nathan J Zvaifler; Mitsufumi Nishio; David L Boyle; Susan L Kalled; Dennis A Carson; Thomas Kipps
Fibroblast-like synoviocytes of mesenchymal origin express functional B cell-activating factor of the TNF family in response to proinflammatory cytokines.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(2):864-70.
2004: Egle Simelyte; David L Boyle; Gary S Firestein
DNA mismatch repair enzyme expression in synovial tissue.
Annals of the rheumatic diseases 2004;63(12):1695-9.
2004: Hal M Hoffman; Sanna Rosengren; David L Boyle; Jae Y Cho; Jyothi Nayar; James L Mueller; Justin P Anderson; Alan A Wanderer; Gary S Firestein
Prevention of cold-associated acute inflammation in familial cold autoinflammatory syndrome by interleukin-1 receptor antagonist.
Lancet 2004;364(9447):1779-85.
2004: HyeonJoo Cheon; David L Boyle; Gary S Firestein
Wnt1 inducible signaling pathway protein-3 regulation and microsatellite structure in arthritis.
The Journal of rheumatology 2004;31(11):2106-14.
2004: Justin P Anderson; James L Mueller; Sanna Rosengren; David L Boyle; Philip Schaner; Steven B Cannon; Carl S Goodyear; Hal M Hoffman
Structural, expression, and evolutionary analysis of mouse CIAS1.
Gene 2004;338(1):25-34.
2004: Deepa Hammaker; David L Boyle; Martine Chabaud-Riou; Gary S Firestein
Regulation of c-Jun N-terminal kinase by MEKK-2 and mitogen-activated protein kinase kinase kinases in rheumatoid arthritis.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(3):1612-8.
2003: Linda S Sorkin; James Moore; David L Boyle; Li Yang; Gary S Firestein
Regulation of peripheral inflammation by spinal adenosine: role of somatic afferent fibers.
Experimental neurology 2003;184(1):162-8.
2003: Sanna Rosengren; Gary S Firestein; David L Boyle
Measurement of inflammatory biomarkers in synovial tissue extracts by enzyme-linked immunosorbent assay.
Clinical and diagnostic laboratory immunology 2003;10(6):1002-10.
2003: Monisha Sundarrajan; David L Boyle; Martine Chabaud-Riou; Deepa Hammaker; Gary S Firestein
Expression of the MAPK kinases MKK-4 and MKK-7 in rheumatoid arthritis and their role as key regulators of JNK.
Arthritis and rheumatism 2003;48(9):2450-60.
2003: Linda S Sorkin; Karly Maruyama; David L Boyle; Li Yang; Martin Marsala; Gary S Firestein
Spinal adenosine agonist reduces c-fos and astrocyte activation in dorsal horn of rats with adjuvant-induced arthritis.
Neuroscience letters 2003;340(2):119-22.
2003: Sang-Heon Lee; Dong Kyung Chang; Ajay Goel; C Richard Boland; William Bugbee; David L Boyle; Gary S Firestein
Microsatellite instability and suppressed DNA repair enzyme expression in rheumatoid arthritis.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(4):2214-20.
2003: David L Boyle; Sanna Rosengren; William Bugbee; Arthur Kavanaugh; Gary S Firestein
Quantitative biomarker analysis of synovial gene expression by real-time PCR.
Arthritis research & therapy 2003;5(6):R352-60.
2002: David L Boyle; James Moore; Li Yang; Linda S Sorkin; Gary S Firestein
Spinal adenosine receptor activation inhibits inflammation and joint destruction in rat adjuvant-induced arthritis.
Arthritis and rheumatism 2002;46(11):3076-82.
2002: Yuji Yamanishi; David L Boyle; Sanna Rosengren; Douglas R Green; Nathan J Zvaifler; Gary S Firestein
Regional analysis of p53 mutations in rheumatoid arthritis synovium.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(15):10025-30.
2002: Yuji Yamanishi; David L Boyle; Melody Clark; Rich A Maki; Micky D Tortorella; Elizabeth C Arner; Gary S Firestein
Expression and regulation of aggrecanase in arthritis: the role of TGF-beta.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(3):1405-12.
2002: Yuji Yamanishi; David L Boyle; Michael J Pinkoski; Artin Mahboubi; Tesu Lin; Zuoning Han; Nathan J Zvaifler; Douglas R Green; Gary S Firestein
Regulation of joint destruction and inflammation by p53 in collagen-induced arthritis.
The American journal of pathology 2002;160(1):123-30.
2001: KR Aupperle; Y Yamanishi; Brydon L Bennett; Frank Mercurio; David L Boyle; Gary S Firestein
Expression and regulation of inducible IkappaB kinase (IKK-i) in human fibroblast-like synoviocytes.
Cellular immunology 2001;214(1):54-9.
2001: Paul P Tak; Danielle M Gerlag; KR Aupperle; D A van de Geest; Maria J Overbeek; Brydon L Bennett; David L Boyle; Anthony Manning; Gary S Firestein
Inhibitor of nuclear factor kappaB kinase beta is a key regulator of synovial inflammation.
Arthritis and rheumatism 2001;44(8):1897-907.
2001: Z Han; David L Boyle; Lufen Chang; B Bennett; Michael Karin; L Yang; Anthony Manning; Gary S Firestein
c-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis.
The Journal of clinical investigation 2001;108(1):73-81.
2001: David L Boyle; Elizabeth A Kowaluk; Michael F Jarvis; C H Lee; Shripad S Bhagwat; M Williams; Gary S Firestein
Anti-inflammatory effects of ABT-702, a novel non-nucleoside adenosine kinase inhibitor, in rat adjuvant arthritis.
The Journal of pharmacology and experimental therapeutics 2001;296(2):495-500.
2000: David L Boyle; Y Shi; S Gay; Gary S Firestein
Regulation of CS1 fibronectin expression and function by IL-1 in endothelial cells.
Cellular immunology 2000;200(1):1-7.
1999: David L Boyle; KH Nguyen; S Zhuang; Y Shi; JE McCormack; Sunil Chada; Gary S Firestein
Intra-articular IL-4 gene therapy in arthritis: anti-inflammatory effect and enhanced th2activity.
Gene therapy 1999;6(12):1911-8.
1999: Z Han; David L Boyle; KR Aupperle; B Bennett; A M Manning; Gary S Firestein
Jun N-terminal kinase in rheumatoid arthritis.
The Journal of pharmacology and experimental therapeutics 1999;291(1):124-30.
1999: KR Aupperle; Brydon L Bennett; David L Boyle; Paul P Tak; Anthony Manning; Gary S Firestein
NF-kappa B regulation by I kappa B kinase in primary fibroblast-like synoviocytes.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(1):427-33.
1999: Z Han; David L Boyle; Y Shi; Douglas R Green; Gary S Firestein
Dominant-negative p53 mutations in rheumatoid arthritis.
Arthritis and rheumatism 1999;42(6):1088-92.
1999: Paul P Tak; Tom J M Smeets; David L Boyle; Maarten C Kraan; Y Shi; S Zhuang; Nathan J Zvaifler; F C Breedveld; Gary S Firestein
p53 overexpression in synovial tissue from patients with early and longstanding rheumatoid arthritis compared with patients with reactive arthritis and osteoarthritis.
Arthritis and rheumatism 1999;42(5):948-53.
1998: KH Nguyen; David L Boyle; JE McCormack; Sunil Chada; Douglas J Jolly; Gary S Firestein
Direct synovial gene transfer with retroviral vectors in rat adjuvant arthritis.
The Journal of rheumatology 1998;25(6):1118-25.
1998: KR Aupperle; David L Boyle; M Hendrix; E A Seftor; Nathan J Zvaifler; M Barbosa; Gary S Firestein
Regulation of synoviocyte proliferation, apoptosis, and invasion by the p53 tumor suppressor gene.
The American journal of pathology 1998;152(4):1091-8.
1998: Z Han; David L Boyle; A M Manning; Gary S Firestein
AP-1 and NF-kappaB regulation in rheumatoid arthritis and murine collagen-induced arthritis.
Autoimmunity 1998;28(4):197-208.
1996: Gary S Firestein; K Nguyen; KR Aupperle; M Yeo; David L Boyle; Nathan J Zvaifler
Apoptosis in rheumatoid arthritis: p53 overexpression in rheumatoid arthritis synovium.
The American journal of pathology 1996;149(6):2143-51.
1996: David L Boyle; F G Sajjadi; Gary S Firestein
Inhibition of synoviocyte collagenase gene expression by adenosine receptor stimulation.
Arthritis and rheumatism 1996;39(6):923-30.
1996: F G Sajjadi; David L Boyle; R C Domingo; Gary S Firestein
cDNA cloning and characterization of A3i, an alternatively spliced rat A3 adenosine receptor variant.
FEBS letters 1996;382(1-2):125-9.
1994: Gary S Firestein; David L Boyle; C Yu; M M Paine; T D Whisenand; Nathan J Zvaifler; William P Arend
Synovial interleukin-1 receptor antagonist and interleukin-1 balance in rheumatoid arthritis.
Arthritis and rheumatism 1994;37(5):644-52.
1994: Gary S Firestein; M M Paine; David L Boyle
Mechanisms of methotrexate action in rheumatoid arthritis. Selective decrease in synovial collagenase gene expression.
Arthritis and rheumatism 1994;37(2):193-200.