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Iontcho Vlahov

Research Profile

Chemicals & Drugs

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Deepika Dhawan; Lindsey M Fourez; Patrick J Klein; Liang Cheng; Michael Koch; Christopher P Leamon; Philip S Low; Linda Murphy; James F Naughton; Nikki Parker; José A Ramos-Vara; Joseph A Reddy; Ryan Rothenbuhler; Jane C Stewart; Iontcho R Vlahov; Deborah W Knapp
Targeting folate receptors to treat invasive urinary bladder cancer.
Jonathan Shillingford; Iontcho R Vlahov; Christopher P Leamon; Thomas Weimbs
Folate-conjugated rapamycin slows progression of polycystic kidney disease.
Iontcho R Vlahov; Christopher P Leamon
Engineering folate-drug conjugates to target cancer: from chemistry to clinic.

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All Publications

2013: Deepika Dhawan; Lindsey M Fourez; Patrick J Klein; Liang Cheng; Michael Koch; Christopher P Leamon; Philip S Low; Linda Murphy; James F Naughton; Nikki Parker; José A Ramos-Vara; Joseph A Reddy; Ryan Rothenbuhler; Jane C Stewart; Iontcho R Vlahov; Deborah W Knapp
Targeting folate receptors to treat invasive urinary bladder cancer.
Cancer research 2013;73(2):875-84.
2012: Jonathan Shillingford; Iontcho R Vlahov; Christopher P Leamon; Thomas Weimbs
Folate-conjugated rapamycin slows progression of polycystic kidney disease.
Journal of the American Society of Nephrology : JASN 2012;23(10):1674-81.
2012: Iontcho R Vlahov; Christopher P Leamon
Engineering folate-drug conjugates to target cancer: from chemistry to clinic.
Bioconjugate chemistry 2012;23(7):1357-69.
2011: Iontcho R Vlahov; Yu Wang; Spencer Hahn; Paul J Kleindl; Joseph A Reddy; Marilynn vetzel; Christopher P Leamon
Acid mediated formation of an N-acyliminium ion from tubulysins: a new methodology for the synthesis of natural tubulysins and their analogs.
Bioorganic & medicinal chemistry letters 2011;21(22):6778-81.
2011: Cristina Müller; Hari Krishna R Santhapuram; Christopher P Leamon; Iontcho R Vlahov; Roger Schibli
Tumor targeting using 67Ga-DOTA-Bz-folate--investigations of methods to improve the tissue distribution of radiofolates.
Nuclear medicine and biology 2011;38(5):715-23.
2011: Iontcho R Vlahov; Fei You; Hari Krishna R Santhapuram; Yu Wang; Jeremy F Vaughn; Spencer J Hahn; Paul J Kleindl; Mingjin Fan; Christopher P Leamon
Design and regioselective synthesis of a new generation of targeted therapeutics. Part 3: Folate conjugates of aminopterin hydrazide for the treatment of inflammation.
Bioorganic & medicinal chemistry letters 2011;21(4):1202-5.
2011: Christopher P Leamon; Joseph A Reddy; Patrick J Klein; Iontcho R Vlahov; Ryan Dorton; Alicia Bloomfield; Melissa Nelson; Elaine Westrick; Nikki Parker; Kristen Bruna; Marilynn vetzel; Mark Gehrke; Jeffrey S Nicoson; Richard A Messmann; Patricia M LoRusso; Edward A Sausville
Reducing undesirable hepatic clearance of a tumor-targeted vinca alkaloid via novel saccharopeptidic modifications.
The Journal of pharmacology and experimental therapeutics 2011;336(2):336-43.
2011: Yingjuan Lu; Torian W Stinnette; Iontcho R Vlahov; Elaine Westrick; Vicky A Cross; Mark A Gehrke; Patrick J Klein; Philip S Low; Christopher P Leamon
Treatment of experimental adjuvant arthritis with a novel folate receptor-targeted folic acid-aminopterin conjugate.
Arthritis research & therapy 2011;13(2):R56.
2010: Iontcho R Vlahov; Gregory D Vite; Paul J Kleindl; Yu Wang; Hari Krishna R Santhapuram; Fei You; Stephen J Howard; Soong-Hoon Kim; Francis F Y Lee; Christopher P Leamon
Regioselective synthesis of folate receptor-targeted agents derived from epothilone analogs and folic acid.
Bioorganic & medicinal chemistry letters 2010;20(15):4578-81.
2010: Iontcho R Vlahov; Hari Krishna R Santhapuram; Fei You; Yu Wang; Paul J Kleindl; Spencer J Hahn; Jeremy F Vaughn; Daniel S Reno; Christopher P Leamon
Carbohydrate-based synthetic approach to control toxicity profiles of folate-drug conjugates.
The Journal of organic chemistry 2010;75(11):3685-91.
2009: Yingjuan Lu; Patrick J Klein; Elaine Westrick; Le-Cun Xu; Hari Krishna R Santhapuram; Alicia Bloomfield; Stephen J Howard; Iontcho R Vlahov; P Ron Ellis; Philip S Low; Christopher P Leamon
Strategy to prevent drug-related hypersensitivity in folate-targeted hapten immunotherapy of cancer.
The AAPS journal 2009;11(3):628-38.
2009: Jyothi A. Reddy; Ryan Dorton; Alicia Dawson; Marilynn vetzel; Nikki Parker; Jeffrey S Nicoson; Elaine Westrick; Patrick J Klein; Yu Wang; Iontcho R Vlahov; Christopher P Leamon
In vivo structural activity and optimization studies of folate-tubulysin conjugates.
Molecular pharmaceutics 2009;6(5):1518-25.
2009: Christopher P Leamon; Fei You; Hari Krishna Santhapuram; Mingjin Fan; Iontcho R Vlahov
Properties influencing the relative binding affinity of pteroate derivatives and drug conjugates thereof to the folate receptor.
Pharmaceutical research 2009;26(6):1315-23.
2008: Iontcho R Vlahov; Yu Wang; Paul J Kleindl; Christopher P Leamon
Design and regioselective synthesis of a new generation of targeted chemotherapeutics. Part II: Folic acid conjugates of tubulysins and their hydrazides.
Bioorganic & medicinal chemistry letters 2008;18(16):4558-61.
2007: Christopher P Leamon; Joseph A Reddy; Iontcho R Vlahov; Elaine Westrick; Nikki Parker; Jeffrey S Nicoson; Marilynn vetzel
Comparative preclinical activity of the folate-targeted Vinca alkaloid conjugates EC140 and EC145.
International journal of cancer. Journal international du cancer 2007;121(7):1585-92.
2007: Christopher P Leamon; Joseph A Reddy; Iontcho R Vlahov; Elaine Westrick; Alicia Dawson; Ryan Dorton; Marilynn vetzel; Hari Krishna R Santhapuram; Yu Wang
Preclinical antitumor activity of a novel folate-targeted dual drug conjugate.
Molecular pharmaceutics 2007;4(5):659-67.
2007: Yingjuan Lu; Fei You; Iontcho R Vlahov; Elaine Westrick; Mingjin Fan; Philip S Low; Christopher P Leamon
Folate-targeted dinitrophenyl hapten immunotherapy: effect of linker chemistry on antitumor activity and allergic potential.
Molecular pharmaceutics 2007;4(5):695-706.
2007: Iontcho R Vlahov; Hari Krishna R Santhapuram; Yu Wang; Paul J Kleindl; Fei You; Stephen J Howard; Elaine Westrick; Joseph A Reddy; Christopher P Leamon
An assembly concept for the consecutive introduction of unsymmetrical disulfide bonds: synthesis of a releasable multidrug conjugate of folic acid.
The Journal of organic chemistry 2007;72(16):5968-72.
2007: Joseph A Reddy; Elaine Westrick; Hari K R Santhapuram; Stephen J Howard; Michael L Miller; Marilynn vetzel; Iontcho R Vlahov; Ravi V J Chari; Victor S Goldmacher; Christopher P Leamon
Folate receptor-specific antitumor activity of EC131, a folate-maytansinoid conjugate.
Cancer research 2007;67(13):6376-82.
2007: Joseph A Reddy; Ryan Dorton; Elaine Westrick; Alicia Dawson; Terri Smith; Le-Cun Xu; Marilynn vetzel; Paul J Kleindl; Iontcho R Vlahov; Christopher P Leamon
Preclinical evaluation of EC145, a folate-vinca alkaloid conjugate.
Cancer research 2007;67(9):4434-42.
2007: Jun Yang; Hongtao Chen; Iontcho R Vlahov; Ji-Xin Cheng; Philip S Low
Characterization of the pH of folate receptor-containing endosomes and the rate of hydrolysis of internalized acid-labile folate-drug conjugates.
The Journal of pharmacology and experimental therapeutics 2007;321(2):462-8.
2006: Iontcho R Vlahov; Hari Krishna R Santhapuram; Paul J Kleindl; Stephen J Howard; Katheryn M Stanford; Christopher P Leamon
Design and regioselective synthesis of a new generation of targeted chemotherapeutics. Part 1: EC145, a folic acid conjugate of desacetylvinblastine monohydrazide.
Bioorganic & medicinal chemistry letters 2006;16(19):5093-6.
2006: Jun Yang; Hongtao Chen; Iontcho R Vlahov; Ji-Xin Cheng; Philip S Low
Evaluation of disulfide reduction during receptor-mediated endocytosis by using FRET imaging.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(37):13872-7.
2006: Christopher P Leamon; Joseph A Reddy; Iontcho R Vlahov; Paul J Kleindl; Marilynn vetzel; Elaine Westrick
Synthesis and biological evaluation of EC140: a novel folate-targeted vinca alkaloid conjugate.
Bioconjugate chemistry 2006;17(5):1226-32.
2006: Joseph A Reddy; Elaine Westrick; Iontcho R Vlahov; Stephen J Howard; Hari Krishna R Santhapuram; Christopher P Leamon
Folate receptor specific anti-tumor activity of folate-mitomycin conjugates.
Cancer chemotherapy and pharmacology 2006;58(2):229-36.
2005: Christopher P Leamon; Joseph A Reddy; Iontcho R Vlahov; Marilynn vetzel; Nikki Parker; Jeffrey S Nicoson; Le-Cun Xu; Elaine Westrick
Synthesis and biological evaluation of EC72: a new folate-targeted chemotherapeutic.
Bioconjugate chemistry 2005;16(4):803-11.
2002: Christopher P Leamon; Matthew A Parker; Iontcho R Vlahov; Le-Cun Xu; Joseph A Reddy; Marilynn vetzel; Nikki Douglas
Synthesis and biological evaluation of EC20: a new folate-derived, (99m)Tc-based radiopharmaceutical.
Bioconjugate chemistry 2002;13(6):1200-10.
2002: Joseph A Reddy; C Abburi; Hans E J Hofland; Stephen J Howard; Iontcho R Vlahov; Pierre Wils; Christopher P Leamon
Folate-targeted, cationic liposome-mediated gene transfer into disseminated peritoneal tumors.
Gene therapy 2002;9(22):1542-50.