Israel Vlodavsky

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Li Jin-Ping; Vlodavsky Israel
Heparin, heparan sulfate and heparanase in inflammatory reactions.
Domschke Christoph; Schuetz Florian; Ge Yingzi; Seibel Tobias; Falk Christine; Brors Benedikt; Vlodavsky Israel; Sommerfeldt Nora; Sinn Hans-Peter; Kühnle Marie-Christine; Schneeweiss Andreas; Scharf Alexander; Sohn Christof; Schirrmacher Volker; Moldenhauer Gerhard; Momburg Frank; Beckhove Philipp
Intratumoral cytokines and tumor cell biology determine spontaneous breast cancer-specific immune responses and their correlation to prognosis.
Bonertz Andreas; Weitz Jürgen; Pietsch Dong-Ho Kim; Rahbari Nuh N; Schlude Christoph; Ge Yingzi; Juenger Simone; Vlodavsky Israel; Khazaie Khashayarsha; Jaeger Dirk; Reissfelder Christoph; Antolovic Dalibor; Aigner Maximilian; Koch Moritz; Beckhove Philipp
Antigen-specific Tregs control T cell responses against a limited repertoire of tumor antigens in patients with colorectal carcinoma.

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All Publications

2009: Li Jin-Ping; Vlodavsky Israel
Heparin, heparan sulfate and heparanase in inflammatory reactions.
Thrombosis and haemostasis 2009;102(5):823-8.
2009: Domschke Christoph; Schuetz Florian; Ge Yingzi; Seibel Tobias; Falk Christine; Brors Benedikt; Vlodavsky Israel; Sommerfeldt Nora; Sinn Hans-Peter; Kühnle Marie-Christine; Schneeweiss Andreas; Scharf Alexander; Sohn Christof; Schirrmacher Volker; Moldenhauer Gerhard; Momburg Frank; Beckhove Philipp
Intratumoral cytokines and tumor cell biology determine spontaneous breast cancer-specific immune responses and their correlation to prognosis.
Cancer research 2009;69(21):8420-8.
2009: Bonertz Andreas; Weitz Jürgen; Pietsch Dong-Ho Kim; Rahbari Nuh N; Schlude Christoph; Ge Yingzi; Juenger Simone; Vlodavsky Israel; Khazaie Khashayarsha; Jaeger Dirk; Reissfelder Christoph; Antolovic Dalibor; Aigner Maximilian; Koch Moritz; Beckhove Philipp
Antigen-specific Tregs control T cell responses against a limited repertoire of tumor antigens in patients with colorectal carcinoma.
The Journal of clinical investigation 2009;119(11):3311-21.
2009: Fux Liat; Ilan Neta; Sanderson Ralph D; Vlodavsky Israel
Heparanase: busy at the cell surface.
Trends in biochemical sciences 2009;34(10):511-9.
2009: Ostrovsky Olga; Korostishevsky Michael; Shafat Itay; Mayorov Margarita; Ilan Neta; Vlodavsky Israel; Nagler Arnon
Inverse correlation between HPSE gene single nucleotide polymorphisms and heparanase expression: possibility of multiple levels of heparanase regulation.
Journal of leukocyte biology 2009;86(2):445-55.
2009: Fux Liat; Feibish Nir; Cohen-Kaplan Victoria; Gingis-Velitski Svetlana; Feld Sari; Geffen Chen; Vlodavsky Israel; Ilan Neta
Structure-function approach identifies a COOH-terminal domain that mediates heparanase signaling.
Cancer research 2009;69(5):1758-67.
2009: Nasser Nicola J; Avivi Aaron; Shafat Itay; Edovitsky Evgeny; Zcharia Eyal; Ilan Neta; Vlodavsky Israel; Nevo Eviatar
Alternatively spliced Spalax heparanase inhibits extracellular matrix degradation, tumor growth, and metastasis.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(7):2253-8.
2009: Baker Aaron B; Groothuis Adam; Jonas Michael; Ettenson David S; Shazly Tarek; Zcharia Eyal; Vlodavsky Israel; Seifert Philip; Edelman Elazer R
Heparanase alters arterial structure, mechanics, and repair following endovascular stenting in mice.
Circulation research 2009;104(3):380-7.
2009: Sandwall Elina; Bodevin Sabrina; Nasser Nicola J; Nevo Eviatar; Avivi Aaron; Vlodavsky Israel; Li Jin-Ping
Molecular structure of heparan sulfate from Spalax. Implications of heparanase and hypoxia.
The Journal of biological chemistry 2009;284(6):3814-22.
2009: Klipper Eyal; Tatz Ehud; Kisliouk Tatiana; Vlodavsky Israel; Moallem Uzi; Schams Dieter; Lavon Yaniv; Wolfenson David; Meidan Rina
Induction of heparanase in bovine granulosa cells by luteinizing hormone: possible role during the ovulatory process.
Endocrinology 2009;150(1):413-21.
2009: Zcharia Eyal; Jia Juan; Zhang Xiao; Baraz Lea; Lindahl Ulf; Peretz Tamar; Vlodavsky Israel; Li Jin-Ping
Newly generated heparanase knock-out mice unravel co-regulation of heparanase and matrix metalloproteinases.
PloS one 2009;4(4):e5181.
2008: Cohen-Kaplan Victoria; Naroditsky Inna; Zetser Anna; Ilan Neta; Vlodavsky Israel; Doweck Ilana
Heparanase induces VEGF C and facilitates tumor lymphangiogenesis.
International journal of cancer. Journal international du cancer 2008;123(11):2566-73.
2008: Barash Hila; Gross Eitan; Edrei Yifat; Pappo Orit; Spira Gadi; Vlodavsky Israel; Galun Eithan; Matot Idit; Abramovitch Rinat
Functional magnetic resonance imaging monitoring of pathological changes in rodent livers during hyperoxia and hypercapnia.
Hepatology (Baltimore, Md.) 2008;48(4):1232-41.
2008: Trebicz-Geffen Meirav; Robinson Dror; Evron Zoharia; Glaser Tova; Fridkin Mati; Kollander Yehuda; Vlodavsky Israel; Ilan Neta; Law Kit Fong; Cheah Kathryn S E; Chan Danny; Werner Haim; Nevo Zvi
The molecular and cellular basis of exostosis formation in hereditary multiple exostoses.
International journal of experimental pathology 2008;89(5):321-31.
2008: Cohen Esti; Doweck Ilana; Naroditsky Inna; Ben-Izhak Ofer; Kremer Ran; Best Lael A; Vlodavsky Israel; Ilan Neta
Heparanase is overexpressed in lung cancer and correlates inversely with patient survival.
Cancer 2008;113(5):1004-11.
2008: Bitan Menachem; Weiss Lola; Zeira Michael; Reich Shoshana; Pappo Orit; Vlodavsky Israel; Slavin Shimon
Heparanase prevents the development of type 1 diabetes in non-obese diabetic mice by regulating T-cell activation and cytokines production.
Diabetes/metabolism research and reviews 2008;24(5):413-21.
2008: Abboud-Jarrous Ghada; Atzmon Ruth; Peretz Tamar; Palermo Carmela; Gadea Bedrick B; Joyce Johanna A; Vlodavsky Israel
Cathepsin L is responsible for processing and activation of proheparanase through multiple cleavages of a linker segment.
The Journal of biological chemistry 2008;283(26):18167-76.
2008: Spiegel Asaf; Zcharia Eyal; Vagima Yaron; Itkin Tomer; Kalinkovich Alexander; Dar Ayelet; Kollet Orit; Netzer Neta; Golan Karin; Shafat Itay; Ilan Neta; Nagler Arnon; Vlodavsky Israel; Lapidot Tsvee
Heparanase regulates retention and proliferation of primitive Sca-1+/c-Kit+/Lin- cells via modulation of the bone marrow microenvironment.
Blood 2008;111(10):4934-43.
2008: Canaani Jonathan; Ilan Neta; Back Stella; Gutman Guy; Vlodavsky Israel; Grisaru Dan
Heparanase expression increases throughout the endometrial hyperplasia-cancer sequence.
International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics 2008;101(2):166-71.
2008: Nadir Yona; Vlodavsky Israel; Brenner Benjamin
Heparanase, tissue factor, and cancer.
Seminars in thrombosis and hemostasis 2008;34(2):187-94.
2008: Tsiperson Vladislav; Goldshmidt Orit; Ilan Neta; Shoshany Gideon; Vlodavsky Israel; Veitsman Ella; Baruch Yaacov
Heparanase enhances early hepatocyte inclusion in the recipient liver after transplantation in partially hepatectomized rats.
Tissue engineering. Part A 2008;14(3):449-58.
2008: Shafat Itay; Pode Dov; Peretz Tamar; Ilan Neta; Vlodavsky Israel; Nisman Benjamin
Clinical significance of urine heparanase in bladder cancer progression.
Neoplasia (New York, N.Y.) 2008;10(2):125-30.
2008: Lerner Immanuel; Baraz Leah; Pikarsky Eli; Meirovitz Amichay; Edovitsky Evgeny; Peretz Tamar; Vlodavsky Israel; Elkin Michael
Function of heparanase in prostate tumorigenesis: potential for therapy.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(3):668-76.
2008: van den Hoven M J; Wijnhoven T J; Li J-P; Zcharia E; Dijkman H B; Wismans R G; Rops A L; Lensen J F; van den Heuvel L P; van Kuppevelt T H; Vlodavsky I; Berden J H M; van der Vlag J
Reduction of anionic sites in the glomerular basement membrane by heparanase does not lead to proteinuria.
Kidney international 2008;73(3):278-87.
2008: Cohen-Mazor Meital; Sela Shifra; Mazor Rafi; Ilan Neta; Vlodavsky Israel; Rops Angelique L; van der Vlag Johan; Cohen Hector I; Kristal Batya
Are primed polymorphonuclear leukocytes contributors to the high heparanase levels in hemodialysis patients?
American journal of physiology. Heart and circulatory physiology 2008;294(2):H651-8.
2008: Nadir Yona; Brenner Benjamin; Gingis-Velitski Sveta; Levy-Adam Flonia; Ilan Neta; Zcharia Eyal; Nadir Erez; Vlodavsky Israel
Heparanase induces tissue factor pathway inhibitor expression and extracellular accumulation in endothelial and tumor cells.
Thrombosis and haemostasis 2008;99(1):133-41.
2008: Casu Benito; Vlodavsky Israel; Sanderson Ralph D
Non-anticoagulant heparins and inhibition of cancer.
Pathophysiology of haemostasis and thrombosis 2008;36(3-4):195-203.
2008: Vlodavsky Israel; Elkin Michael; Abboud-Jarrous Ghada; Levi-Adam Flonia; Fuks Liat; Shafat Itay; Ilan Neta
Heparanase: one molecule with multiple functions in cancer progression.
Connective tissue research 2008;49(3):207-10.
2008: Levy-Adam Flonia; Feld Sari; Suss-Toby Edith; Vlodavsky Israel; Ilan Neta
Heparanase facilitates cell adhesion and spreading by clustering of cell surface heparan sulfate proteoglycans.
PloS one 2008;3(6):e2319.
2008: Ben-Zaken Olga; Shafat Itay; Gingis-Velitski Svetlana; Bangio Haim; Kelson Idil Kasuto; Alergand Tal; Amor Yehudit; Maya Ruth Ben-Yakar; Vlodavsky Israel; Ilan Neta
Low and high affinity receptors mediate cellular uptake of heparanase.
The international journal of biochemistry & cell biology 2008;40(3):530-42.
2007: Katz Ben-Zion; Muhl Lars; Zwang Etty; Ilan Neta; Herishanu Yair; Deutsch Varda; Naparstek Elizabeth; Vlodavsky Israel; Preissner Klaus T
Heparanase modulates heparinoids anticoagulant activities via non-enzymatic mechanisms.
Thrombosis and haemostasis 2007;98(6):1193-9.
2007: Patel Vaishali N; Knox Sarah M; Likar Karen M; Lathrop Colin A; Hossain Rydhwana; Eftekhari Siavash; Whitelock John M; Elkin Michael; Vlodavsky Israel; Hoffman Matthew P
Heparanase cleavage of perlecan heparan sulfate modulates FGF10 activity during ex vivo submandibular gland branching morphogenesis.
Development (Cambridge, England) 2007;134(23):4177-86.
2007: Nagler Rafael; Ben-Izhak Ofer; Cohen-Kaplan Victoria; Shafat Itay; Vlodavsky Israel; Akrish Sharon; Ilan Neta
Heparanase up-regulation in tongue cancer: tissue and saliva analysis.
Cancer 2007;110(12):2732-9.
2007: Escobar Galvis Martha L; Jia Juan; Zhang Xiao; Jastrebova Nadja; Spillmann Dorothe; Gottfridsson Eva; van Kuppevelt Toin H; Zcharia Eyal; Vlodavsky Israel; Lindahl Ulf; Li Jin-Ping
Transgenic or tumor-induced expression of heparanase upregulates sulfation of heparan sulfate.
Nature chemical biology 2007;3(12):773-8.
2007: Gingis-Velitski Svetlana; Ishai-Michaeli Rivka; Vlodavsky Israel; Ilan Neta
Anti-heparanase monoclonal antibody enhances heparanase enzymatic activity and facilitates wound healing.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2007;21(14):3986-93.
2007: Shafat Itay; Barak Ayelet Ben; Postovsky Sergey; Elhasid Ronit; Ilan Neta; Vlodavsky Israel; Arush Miriam Weyl Ben
Heparanase levels are elevated in the plasma of pediatric cancer patients and correlate with response to anticancer treatment.
Neoplasia (New York, N.Y.) 2007;9(11):909-16.
2007: Ostrovsky O; Korostishevsky M; Levite I; Leiba M; Galski H; Vlodavsky I; Nagler A
Association of heparanase gene (HPSE) single nucleotide polymorphisms with hematological malignancies.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2007;21(11):2296-303.
2007: Hostettler Nina; Naggi Annamaria; Torri Giangiacomo; Ishai-Michaeli Riva; Casu Benito; Vlodavsky Israel; Borsig Lubor
P-selectin- and heparanase-dependent antimetastatic activity of non-anticoagulant heparins.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2007;21(13):3562-72.
2007: Ben-Zaken Olga; Gingis-Velitski Svetlana; Vlodavsky Israel; Ilan Neta
Heparanase induces Akt phosphorylation via a lipid raft receptor.
Biochemical and biophysical research communications 2007;361(4):829-34.
2007: Yang Yang; MacLeod Veronica; Dai Yuemeng; Khotskaya-Sample Yekaterina; Shriver Zachary; Venkataraman Ganesh; Sasisekharan Ram; Naggi Annamaria; Torri Giangiacomo; Casu Benito; Vlodavsky Israel; Suva Larry J; Epstein Joshua; Yaccoby Shmuel; Shaughnessy John D; Barlogie Bart; Sanderson Ralph D
The syndecan-1 heparan sulfate proteoglycan is a viable target for myeloma therapy.
Blood 2007;110(6):2041-8.
2007: Bashenko Yulia; Ilan Neta; Krausz Michael M; Vlodavsky Israel; Hirsh Mark I
Heparanase pretreatment attenuates endotoxin-induced acute lung injury in rats.
Shock (Augusta, Ga.) 2007;28(2):207-12.
2007: Cohen Irit; Maly Bella; Simon Itamar; Meirovitz Amichay; Pikarsky Eli; Zcharia Eyal; Peretz Tamar; Vlodavsky Israel; Elkin Michael
Tamoxifen induces heparanase expression in estrogen receptor-positive breast cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(14):4069-77.
2007: Borgenström Marjut; Wärri Anni; Hiilesvuo Katri; Käkönen Rami; Käkönen Sanna; Nissinen Liisa; Pihlavisto Marjo; Marjamäki Anne; Vlodavsky Israel; Naggi Annamaria; Torri Giangiacomo; Casu Benito; Veromaa Timo; Salmivirta Markku; Elenius Klaus
O-sulfated bacterial polysaccharides with low anticoagulant activity inhibit metastasis.
Seminars in thrombosis and hemostasis 2007;33(5):547-56.
2007: Barash Hila; Gross Eitan; Matot Idit; Edrei Yifat; Tsarfaty Galia; Spira Gadi; Vlodavsky Israel; Galun Eithan; Abramovitch Rinat
Functional MR imaging during hypercapnia and hyperoxia: noninvasive tool for monitoring changes in liver perfusion and hemodynamics in a rat model.
Radiology 2007;243(3):727-35.
2007: Yang Yang; Macleod Veronica; Miao Hua-Quan; Theus Allison; Zhan Fenghuang; Shaughnessy John D; Sawyer Jeffrey; Li Jin-Ping; Zcharia Eyal; Vlodavsky Israel; Sanderson Ralph D
Heparanase enhances syndecan-1 shedding: a novel mechanism for stimulation of tumor growth and metastasis.
The Journal of biological chemistry 2007;282(18):13326-33.
2007: Nasser Nicola J; Avivi Aaron; Shushy Moran; Vlodavsky Israel; Nevo Eviatar
Cloning, expression, and characterization of an alternatively spliced variant of human heparanase.
Biochemical and biophysical research communications 2007;354(1):33-8.
2007: Doviner V; Maly B; Reinhartz T; Vlodavsky I; Sherman Y
Heparanase expression: a potential ancillary diagnostic tool for distinguishing between malignant cells and reactive mesothelium in body cavity effusions.
Cytopathology : official journal of the British Society for Clinical Cytology 2007;18(1):13-9.
2007: Davidson Ben; Shafat Itai; Risberg Björn; Ilan Neta; Trope' Claes G; Vlodavsky Israel; Reich Reuven
Heparanase expression correlates with poor survival in metastatic ovarian carcinoma.
Gynecologic oncology 2007;104(2):311-9.
2007: Waterman Matti; Ben-Izhak Ofer; Eliakim Rami; Groisman Gabriel; Vlodavsky Israel; Ilan Neta
Heparanase upregulation by colonic epithelium in inflammatory bowel disease.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2007;20(1):8-14.
2007: Vlodavsky Israel; Ilan Neta; Nadir Yona; Brenner Benjamin; Katz Ben-Zion; Naggi Annamaria; Torri Giangiacomo; Casu Benito; Sasisekharan Ram
Heparanase, heparin and the coagulation system in cancer progression.
Thrombosis research 2007;120 Suppl 2():S112-20.
2007: Vlodavsky Israel; Ilan Neta; Naggi Annamaria; Casu Benito
Heparanase: structure, biological functions, and inhibition by heparin-derived mimetics of heparan sulfate.
Current pharmaceutical design 2007;13(20):2057-73.
2007: Ostrovsky Olga; Korostishevsky Michael; Levite Iris; Leiba Merav; Galski Hanan; Gazit Ephraim; Vlodavsky Israel; Nagler Arnon
Characterization of HPSE gene single nucleotide polymorphisms in Jewish populations of Israel.
Acta haematologica 2007;117(1):57-64.
2006: Doweck Ilana; Kaplan-Cohen Victoria; Naroditsky Inna; Sabo Edmond; Ilan Neta; Vlodavsky Israel
Heparanase localization and expression by head and neck cancer: correlation with tumor progression and patient survival.
Neoplasia (New York, N.Y.) 2006;8(12):1055-61.
2006: Nadir Y; Brenner B; Zetser A; Ilan N; Shafat I; Zcharia E; Goldshmidt O; Vlodavsky I
Heparanase induces tissue factor expression in vascular endothelial and cancer cells.
Journal of thrombosis and haemostasis : JTH 2006;4(11):2443-51.
2006: Ben-Izhak Ofer; Kaplan-Cohen Victoria; Ilan Neta; Gan Shlomit; Vlodavsky Israel; Nagler Rafael
Heparanase expression in malignant salivary gland tumors inversely correlates with long-term survival.
Neoplasia (New York, N.Y.) 2006;8(10):879-84.
2006: Rouet Vincent; Meddahi-Pellé Anne; Miao Hua-Quan; Vlodavsky Israel; Caruelle Jean-Pierre; Barritault Denis
Heparin-like synthetic polymers, named RGTAs, mimic biological effects of heparin in vitro.
Journal of biomedical materials research. Part A 2006;78(4):792-7.
2006: Sommerfeldt Nora; Beckhove Philipp; Ge Yingzi; Schütz Florian; Choi Carmen; Bucur Mariana; Domschke Christoph; Sohn Christof; Schneeweis Andreas; Rom Joachim; Pollmann Dirk; Leucht Dagmar; Vlodavsky Israel; Schirrmacher Volker
Heparanase: a new metastasis-associated antigen recognized in breast cancer patients by spontaneously induced memory T lymphocytes.
Cancer research 2006;66(15):7716-23.
2006: Bar-Sela G; Kaplan-Cohen V; Ilan N; Vlodavsky I; Ben-Izhak O
Heparanase expression in nasopharyngeal carcinoma inversely correlates with patient survival.
Histopathology 2006;49(2):188-93.
2006: Shafat Itay; Vlodavsky Israel; Ilan Neta
Characterization of mechanisms involved in secretion of active heparanase.
The Journal of biological chemistry 2006;281(33):23804-11.
2006: Breidenbach Martina; Rein Daniel T; Schöndorf Thomas; Khan Kiran N; Herrmann Isabell; Schmidt Torsten; Reynolds Paul N; Vlodavsky Israel; Haviv Yosef S; Curiel David T
A new targeting approach for breast cancer gene therapy using the heparanase promoter.
Cancer letters 2006;240(1):114-22.
2006: Benhamron Sandrine; Nechushtan Hovav; Verbovetski Inna; Krispin Alon; Abboud-Jarrous Ghada; Zcharia Eyal; Edovitsky Evgeny; Nahari Efrat; Peretz Tamar; Vlodavsky Israel; Mevorach Dror
Translocation of active heparanase to cell surface regulates degradation of extracellular matrix heparan sulfate upon transmigration of mature monocyte-derived dendritic cells.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(11):6417-24.
2006: Doviner Victoria; Maly Bella; Kaplan Victoria; Gingis-Velitski Svetlana; Ilan Neta; Vlodavsky Israel; Sherman Yoav
Spatial and temporal heparanase expression in colon mucosa throughout the adenoma-carcinoma sequence.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2006;19(6):878-88.
2006: Kram Vardit; Zcharia Eyal; Yacoby-Zeevi Oron; Metzger Shula; Chajek-Shaul Tova; Gabet Yankel; Müller Ralph; Vlodavsky Israel; Bab Itai
Heparanase is expressed in osteoblastic cells and stimulates bone formation and bone mass.
Journal of cellular physiology 2006;207(3):784-92.
2006: Edovitsky Evgeny; Lerner Immanuel; Zcharia Eyal; Peretz Tamar; Vlodavsky Israel; Elkin Michael
Role of endothelial heparanase in delayed-type hypersensitivity.
Blood 2006;107(9):3609-16.
2006: Cohen Irit; Pappo Orit; Elkin Michael; San Tamara; Bar-Shavit Rachel; Hazan Rachel; Peretz Tamar; Vlodavsky Israel; Abramovitch Rinat
Heparanase promotes growth, angiogenesis and survival of primary breast tumors.
International journal of cancer. Journal international du cancer 2006;118(7):1609-17.
2006: Nasser N J; Sarig G; Brenner B; Nevo E; Goldshmidt O; Zcharia E; Li J P; Vlodavsky I
Heparanase neutralizes the anticoagulation properties of heparin and low-molecular-weight heparin.
Journal of thrombosis and haemostasis : JTH 2006;4(3):560-5.
2006: Shafat Itay; Zcharia Eyal; Nisman Benjamin; Nadir Yona; Nakhoul Farid; Vlodavsky Israel; Ilan Neta
An ELISA method for the detection and quantification of human heparanase.
Biochemical and biophysical research communications 2006;341(4):958-63.
2006: Zetser Anna; Bashenko Yulia; Edovitsky Evgeny; Levy-Adam Flonia; Vlodavsky Israel; Ilan Neta
Heparanase induces vascular endothelial growth factor expression: correlation with p38 phosphorylation levels and Src activation.
Cancer research 2006;66(3):1455-63.
2006: Ilan Neta; Elkin Michael; Vlodavsky Israel
Regulation, function and clinical significance of heparanase in cancer metastasis and angiogenesis.
The international journal of biochemistry & cell biology 2006;38(12):2018-39.
2006: Vlodavsky Israel; Abboud-Jarrous Ghada; Elkin Micahel; Naggi Annamaria; Casu Benito; Sasisekharan Ram; Ilan Neta
The impact of heparanese and heparin on cancer metastasis and angiogenesis.
Pathophysiology of haemostasis and thrombosis 2006;35(1-2):116-27.
2005: Nasser Nicola J; Nevo Eviatar; Shafat Itay; Ilan Neta; Vlodavsky Israel; Avivi Aaron
Adaptive evolution of heparanase in hypoxia-tolerant Spalax: gene cloning and identification of a unique splice variant.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(42):15161-6.
2005: Eshel Rinat; Ben-Zaken Olga; Vainas Oded; Nadir Yona; Minucci Saverio; Polliack Aaron; Naparstek Ella; Vlodavsky Israel; Katz Ben-Zion
Leukomogenic factors downregulate heparanase expression in acute myeloid leukemia cells.
Biochemical and biophysical research communications 2005;335(4):1115-22.
2005: Haimov-Kochman Ronit; Prus Diana; Zcharia Eyal; Goldman-Wohl Debra S; Natanson-Yaron Shira; Greenfield Caryn; Anteby Eyal Y; Reich Reuven; Orly Joseph; Tsafriri Alex; Hurwitz Arye; Vlodavsky Israel; Yagel Simcha
Spatiotemporal expression of heparanase during human and rodent ovarian folliculogenesis.
Biology of reproduction 2005;73(1):20-8.
2005: Li Jin-Ping; Galvis Martha L Escobar; Gong Feng; Zhang Xiao; Zcharia Eyal; Metzger Shula; Vlodavsky Israel; Kisilevsky Robert; Lindahl Ulf
In vivo fragmentation of heparan sulfate by heparanase overexpression renders mice resistant to amyloid protein A amyloidosis.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(18):6473-7.
2005: Levy-Adam Flonia; Abboud-Jarrous Ghada; Guerrini Marco; Beccati Daniela; Vlodavsky Israel; Ilan Neta
Identification and characterization of heparin/heparan sulfate binding domains of the endoglycosidase heparanase.
The Journal of biological chemistry 2005;280(21):20457-66.
2005: Cohen Esti; Atzmon Ruth; Vlodavsky Israel; Ilan Neta
Heparanase processing by lysosomal/endosomal protein preparation.
FEBS letters 2005;579(11):2334-8.
2005: Zcharia Eyal; Philp Deborah; Edovitsky Evgeny; Aingorn Helena; Metzger Shula; Kleinman Hynda K; Vlodavsky Israel; Elkin Michael
Heparanase regulates murine hair growth.
The American journal of pathology 2005;166(4):999-1008.
2005: Horonchik Lior; Tzaban Salit; Ben-Zaken Olga; Yedidia Yifat; Rouvinski Alex; Papy-Garcia Dulce; Barritault Denis; Vlodavsky Israel; Taraboulos Albert
Heparan sulfate is a cellular receptor for purified infectious prions.
The Journal of biological chemistry 2005;280(17):17062-7.
2005: Abboud-Jarrous Ghada; Rangini-Guetta Zehava; Aingorn Helena; Atzmon Ruth; Elgavish Sharona; Peretz Tamar; Vlodavsky Israel
Site-directed mutagenesis, proteolytic cleavage, and activation of human proheparanase.
The Journal of biological chemistry 2005;280(14):13568-75.
2005: Naggi Annamaria; Casu Benito; Perez Marta; Torri Giangiacomo; Cassinelli Giuseppe; Penco Sergio; Pisano Claudio; Giannini Giuseppe; Ishai-Michaeli Rivka; Vlodavsky Israel
Modulation of the heparanase-inhibiting activity of heparin through selective desulfation, graded N-acetylation, and glycol splitting.
The Journal of biological chemistry 2005;280(13):12103-13.
2005: Dafni Hagit; Cohen Batya; Ziv Keren; Israely Tomer; Goldshmidt Orit; Nevo Nava; Harmelin Alon; Vlodavsky Israel; Neeman Michal
The role of heparanase in lymph node metastatic dissemination: dynamic contrast-enhanced MRI of Eb lymphoma in mice.
Neoplasia (New York, N.Y.) 2005;7(3):224-33.
2005: Ueno Yushi; Yamamoto Masaaki; Vlodavsky Israel; Pecker Iris; Ohshima Kohichi; Fukushima Takeo
Decreased expression of heparanase in glioblastoma multiforme.
Journal of neurosurgery 2005;102(3):513-21.
2005: Revel Ariel; Helman Aharon; Koler Moriah; Shushan Asher; Goldshmidt Orit; Zcharia Eyal; Aingorn Helena; Vlodavsky Israel
Heparanase improves mouse embryo implantation.
Fertility and sterility 2005;83(3):580-6.
2005: Zcharia Eyal; Zilka Rachel; Yaar Alon; Yacoby-Zeevi Oron; Zetser Anna; Metzger Shula; Sarid Ronit; Naggi Annamaria; Casu Benito; Ilan Neta; Vlodavsky Israel; Abramovitch Rinat
Heparanase accelerates wound angiogenesis and wound healing in mouse and rat models.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005;19(2):211-21.
2004: Gingis-Velitski Svetlana; Zetser Anna; Kaplan Victoria; Ben-Zaken Olga; Cohen Esti; Levy-Adam Flonia; Bashenko Yulia; Flugelman Moshe Y; Vlodavsky Israel; Ilan Neta
Heparanase uptake is mediated by cell membrane heparan sulfate proteoglycans.
The Journal of biological chemistry 2004;279(42):44084-92.
2004: Abramovitch Rinat; Itzik Anna; Harel Hila; Nagler Arnon; Vlodavsky Israel; Siegal Tali
Halofuginone inhibits angiogenesis and growth in implanted metastatic rat brain tumor model--an MRI study.
Neoplasia (New York, N.Y.) 2004;6(5):480-9.
2004: Edovitsky Evgeny; Elkin Michael; Zcharia Eyal; Peretz Tamar; Vlodavsky Israel
Heparanase gene silencing, tumor invasiveness, angiogenesis, and metastasis.
Journal of the National Cancer Institute 2004;96(16):1219-30.
2004: Bloushtain Noga; Qimron Udi; Bar-Ilan Ahuva; Hershkovitz Oren; Gazit Roi; Fima Eyal; Korc Murray; Vlodavsky Israel; Bovin Nicolai V; Porgador Angel
Membrane-associated heparan sulfate proteoglycans are involved in the recognition of cellular targets by NKp30 and NKp46.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(4):2392-401.
2004: Zetser Anna; Levy-Adam Flonia; Kaplan Victoria; Gingis-Velitski Svetlana; Bashenko Yulia; Schubert Shay; Flugelman Moshe Y; Vlodavsky Israel; Ilan Neta
Processing and activation of latent heparanase occurs in lysosomes.
Journal of cell science 2004;117(Pt 11):2249-58.
2004: Sotnikov Ilya; Hershkoviz Rami; Grabovsky Valentin; Ilan Neta; Cahalon Liora; Vlodavsky Israel; Alon Ronen; Lider Ofer
Enzymatically quiescent heparanase augments T cell interactions with VCAM-1 and extracellular matrix components under versatile dynamic contexts.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(9):5185-93.
2004: Goldshmidt Orit; Yeikilis Rita; Mawasi Nidal; Paizi Melia; Gan Noga; Ilan Neta; Pappo Orit; Vlodavsky Israel; Spira Gadi
Heparanase expression during normal liver development and following partial hepatectomy.
The Journal of pathology 2004;203(1):594-602.
2004: Gingis-Velitski Svetlana; Zetser Anna; Flugelman Moshe Y; Vlodavsky Israel; Ilan Neta
Heparanase induces endothelial cell migration via protein kinase B/Akt activation.
The Journal of biological chemistry 2004;279(22):23536-41.
2004: Schubert Shay Y; Ilan Neta; Shushy Moran; Ben-Izhak Ofer; Vlodavsky Israel; Goldshmidt Orit
Human heparanase nuclear localization and enzymatic activity.
Laboratory investigation; a journal of technical methods and pathology 2004;84(5):535-44.
2004: Temkin Vladislav; Aingorn Helena; Puxeddu Ilaria; Goldshmidt Orit; Zcharia Eyal; Gleich Gerald J; Vlodavsky Israel; Levi-Schaffer Francesca
Eosinophil major basic protein: first identified natural heparanase-inhibiting protein.
The Journal of allergy and clinical immunology 2004;113(4):703-9.
2004: Berk Richard S; Dong Zhong; Alousi Sarah; Kosir Mary Ann; Wang Yuying; Vlodavsky Israel
Murine ocular heparanase expression before and during infection with Pseudomonas aeruginosa.
Investigative ophthalmology & visual science 2004;45(4):1182-7.
2004: Zcharia Eyal; Metzger Shula; Chajek-Shaul Tova; Aingorn Helena; Elkin Michael; Friedmann Yael; Weinstein Talia; Li Jin-Ping; Lindahl Ulf; Vlodavsky Israel
Transgenic expression of mammalian heparanase uncovers physiological functions of heparan sulfate in tissue morphogenesis, vascularization, and feeding behavior.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004;18(2):252-63.
2004: Navab Roya; Aingorn Helena; Fallavollita Lucia; Sallon Sara; Mechoulam Raphael; Ginsburg Isaac; Vlodavsky Israel; Brodt Pnina
PADMA-28, a traditional Tibetan herbal preparation, blocks cellular responses to bFGF and IGF-I.
Inflammopharmacology 2004;12(4):373-89.
2004: Davidson Ben; Vintman Lina; Zcharia Eyal; Bedrossian Carlos; Berner Aasmund; Nielsen Søren; Ilan Neta; Vlodavsky Israel; Reich Reuven
Heparanase and basic fibroblast growth factor are co-expressed in malignant mesothelioma.
Clinical & experimental metastasis 2004;21(5):469-76.
2003: Elkin Michael; Cohen Irit; Zcharia Eyal; Orgel Adam; Guatta-Rangini Zehava; Peretz Tamar; Vlodavsky Israel; Kleinman Hynda K
Regulation of heparanase gene expression by estrogen in breast cancer.
Cancer research 2003;63(24):8821-6.
2003: Zetser Anna; Bashenko Yulia; Miao Hua-Quan; Vlodavsky Israel; Ilan Neta
Heparanase affects adhesive and tumorigenic potential of human glioma cells.
Cancer research 2003;63(22):7733-41.
2003: Shteper Pesach J; Zcharia Eyal; Ashhab Yaqoub; Peretz Tamar; Vlodavsky Israel; Ben-Yehuda Dina
Role of promoter methylation in regulation of the mammalian heparanase gene.
Oncogene 2003;22(49):7737-49.
2003: Ben-Zaken Olga; Tzaban Salit; Tal Yuval; Horonchik Lior; Esko Jeffrey D; Vlodavsky Israel; Taraboulos Albert
Cellular heparan sulfate participates in the metabolism of prions.
The Journal of biological chemistry 2003;278(41):40041-9.
2003: Levy-Adam Flonia; Miao Hua-Quan; Heinrikson Robert L; Vlodavsky Israel; Ilan Neta
Heterodimer formation is essential for heparanase enzymatic activity.
Biochemical and biophysical research communications 2003;308(4):885-91.
2003: Gong Feng; Jemth Per; Escobar Galvis Martha L; Vlodavsky Israel; Horner Alan; Lindahl Ulf; Li Jin-ping
Processing of macromolecular heparin by heparanase.
The Journal of biological chemistry 2003;278(37):35152-8.
2003: Goldshmidt Orit; Zcharia Eyal; Cohen Miriam; Aingorn Helena; Cohen Irit; Nadav Liat; Katz Ben-Zion; Geiger Benjamin; Vlodavsky Israel
Heparanase mediates cell adhesion independent of its enzymatic activity.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(9):1015-25.
2003: Irony-Tur-Sinai Michal; Vlodavsky Israel; Ben-Sasson Shmuel A; Pinto Florence; Sicsic Camille; Brenner Talma
A synthetic heparin-mimicking polyanionic compound inhibits central nervous system inflammation.
Journal of the neurological sciences 2003;206(1):49-57.
2003: Vlodavsky I; Zcharia E; Goldshmidt O; Eshel R; Katz B-Z; Minucci S; Kovalchuk O; Penco S; Pisano C; Naggi A; Casu B
Involvement of heparanase in tumor progression and normal differentiation.
Pathophysiology of haemostasis and thrombosis 2003;33 Suppl 1():59-61.
2002: Katz Avi; Van-Dijk David J; Aingorn Helena; Erman Arie; Davies Malcolm; Darmon David; Hurvitz Hagit; Vlodavsky Israel
Involvement of human heparanase in the pathogenesis of diabetic nephropathy.
The Israel Medical Association journal : IMAJ 2002;4(11):996-1002.
2002: Goldshmidt Orit; Nadav Liat; Aingorn Helena; Irit Cohen; Feinstein Naomi; Ilan Neta; Zamir Eli; Geiger Benjamin; Vlodavsky Israel; Katz Ben Zion
Human heparanase is localized within lysosomes in a stable form.
Experimental cell research 2002;281(1):50-62.
2002: Benezra Miriam; Ishai-Michaeli Rivka; Ben-Sasson Shmuel A; Vlodavsky Israel
Structure-activity relationships of heparin-mimicking compounds in induction of bFGF release from extracellular matrix and inhibition of smooth muscle cell proliferation and heparanase activity.
Journal of cellular physiology 2002;192(3):276-85.
2002: Goldshmidt Orit; Zcharia Eyal; Abramovitch Rinat; Metzger Shula; Aingorn Helena; Friedmann Yael; Schirrmacher Volker; Mitrani Eduardo; Vlodavsky Israel
Cell surface expression and secretion of heparanase markedly promote tumor angiogenesis and metastasis.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(15):10031-6.
2002: Haimov-Kochman Ronit; Friedmann Yael; Prus Diana; Goldman-Wohl Debra S; Greenfield Caryn; Anteby Eyal Y; Aviv Ayelet; Vlodavsky Israel; Yagel Simcha
Localization of heparanase in normal and pathological human placenta.
Molecular human reproduction 2002;8(6):566-73.
2002: Nadav Liat; Eldor Amiram; Yacoby-Zeevi Oron; Zamir Eli; Pecker Iris; Ilan Neta; Geiger Benjamin; Vlodavsky Israel; Katz Ben-Zion
Activation, processing and trafficking of extracellular heparanase by primary human fibroblasts.
Journal of cell science 2002;115(Pt 10):2179-87.
2002: Vlodavsky Israel; Goldshmidt Orit; Zcharia Eyal; Atzmon Ruth; Rangini-Guatta Zehava; Elkin Michael; Peretz Tamar; Friedmann Yael
Mammalian heparanase: involvement in cancer metastasis, angiogenesis and normal development.
Seminars in cancer biology 2002;12(2):121-9.
2002: Schmidt Annette; Göpfert Christian; Vlodavsky Israel; Völker Wolfgang; Buddecke Eckhart
Induction of a hypertrophic growth status of coronary smooth muscle cells is associated with an overexpression of TGF-beta.
European journal of cell biology 2002;81(3):138-44.
2002: Bitan Menachem; Polliack Aaron; Zecchina Gabriella; Nagler Arnon; Friedmann Yael; Nadav Liat; Deutsch Varda; Pecker Iris; Eldor Amiram; Vlodavsky Israel; Katz Ben-Zion
Heparanase expression in human leukemias is restricted to acute myeloid leukemias.
Experimental hematology 2002;30(1):34-41.
2002: Shargal Yaron; Viola Nicola; Nagler Arnon; Merin Gideon; Schmidt Annete; Buddecke Erick; Ben-Sasson Shmuel A; Vlodavsky Israel
Inhibition of anastomotic intimal hyperplasia by a synthetic nonsulphated heparin-mimicking compound.
Experimental and clinical cardiology 2002;7(2-3):73-9.
2001: Vlodavsky I; Goldshmidt O; Zcharia E; Metzger S; Chajek-Shaul T; Atzmon R; Guatta-Rangini Z; Friedmann Y
Molecular properties and involvement of heparanase in cancer progression and normal development.
Biochimie 2001;83(8):831-9.
2001: Vlodavsky I; Friedmann Y
Molecular properties and involvement of heparanase in cancer metastasis and angiogenesis.
The Journal of clinical investigation 2001;108(3):341-7.
2001: Goldshmidt O; Zcharia E; Aingorn H; Guatta-Rangini Z; Atzmon R; Michal I; Pecker I; Mitrani E; Vlodavsky I
Expression pattern and secretion of human and chicken heparanase are determined by their signal peptide sequence.
The Journal of biological chemistry 2001;276(31):29178-87.
2001: Zcharia E; Metzger S; Chajek-Shaul T; Friedmann Y; Pappo O; Aviv A; Elkin M; Pecker I; Peretz T; Vlodavsky I
Molecular properties and involvement of heparanase in cancer progression and mammary gland morphogenesis.
Journal of mammary gland biology and neoplasia 2001;6(3):311-22.
2001: Elkin M; Ilan N; Ishai-Michaeli R; Friedmann Y; Papo O; Pecker I; Vlodavsky I
Heparanase as mediator of angiogenesis: mode of action.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2001;15(9):1661-3.
2001: Ginath S; Menczer J; Friedmann Y; Aingorn H; Aviv A; Tajima K; Dantes A; Glezerman M; Vlodavsky I; Amsterdam A
Expression of heparanase, Mdm2, and erbB2 in ovarian cancer.
International journal of oncology 2001;18(6):1133-44.
2001: Vlodavsky I; Goldshmidt O
Properties and function of heparanase in cancer metastasis and angiogenesis.
Haemostasis 2001;31 Suppl 1():60-3.
2001: Benezra M; Vogel T; Ben-Sasson S A; Panet A; Sehayek E; Al-Haideiri M; Decklbaum R J; Vlodavsky I
A synthetic heparin-mimicking polyanionic compound binds to the LDL receptor-related protein and inhibits vascular smooth muscle cell proliferation.
Journal of cellular biochemistry 2001;81(1):114-27.
2000: Deutsch V; Bitan M; Friedmann Y; Eldor A; Vlodavsky I
Megakaryocyte maturation is associated with expression of the CXC chemokine connective tissue-activating peptide CTAP III.
British journal of haematology 2000;111(4):1180-9.
2000: Elkin M; Miao H Q; Nagler A; Aingorn E; Reich R; Hemo I; Dou H L; Pines M; Vlodavsky I
Halofuginone: a potent inhibitor of critical steps in angiogenesis progression.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2000;14(15):2477-85.
2000: Friedmann Y; Vlodavsky I; Aingorn H; Aviv A; Peretz T; Pecker I; Pappo O
Expression of heparanase in normal, dysplastic, and neoplastic human colonic mucosa and stroma. Evidence for its role in colonic tumorigenesis.
The American journal of pathology 2000;157(4):1167-75.
2000: Grisaru D; Vlodavsky I; Prus D; Levavi H; Lessing J B; Eldor A; Friedmann Y
Connective tissue activating peptide III expression disappears progressively with increased dysplasia in human cervical epithelium.
Gynecologic oncology 2000;79(1):23-7.
2000: Vlodavsky I; Elkin M; Pappo O; Aingorn H; Atzmon R; Ishai-Michaeli R; Aviv A; Pecker I; Friedmann Y
Mammalian heparanase as mediator of tumor metastasis and angiogenesis.
The Israel Medical Association journal : IMAJ 2000;2 Suppl():37-45.
2000: Bentolila A; Vlodavsky I; Ishai-Michaeli R; Kovalchuk O; Haloun C; Domb A J
Poly(N-acryl amino acids): a new class of biologically active polyanions.
Journal of medicinal chemistry 2000;43(13):2591-600.
1999: Berman B; Ostrovsky O; Shlissel M; Lang T; Regan D; Vlodavsky I; Ishai-Michaeli R; Ron D
Similarities and differences between the effects of heparin and glypican-1 on the bioactivity of acidic fibroblast growth factor and the keratinocyte growth factor.
The Journal of biological chemistry 1999;274(51):36132-8.
1999: Schmidt A; Vlodavsky I; Völker W; Buddecke E
Differentiation of coronary smooth muscle cells to a cell cycle-arrested hypertrophic growth status by a synthetic non-toxic heparin-mimicking compound.
Atherosclerosis 1999;147(2):387-97.
1999: Miao H Q; Elkin M; Aingorn E; Ishai-Michaeli R; Stein C A; Vlodavsky I
Inhibition of heparanase activity and tumor metastasis by laminarin sulfate and synthetic phosphorothioate oligodeoxynucleotides.
International journal of cancer. Journal international du cancer 1999;83(3):424-31.
1999: Elkin M; Reich R; Nagler A; Aingorn E; Pines M; de-Groot N; Hochberg A; Vlodavsky I
Inhibition of matrix metalloproteinase-2 expression and bladder carcinoma metastasis by halofuginone.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(8):1982-8.
1999: Elkin M; Ariel I; Miao H Q; Nagler A; Pines M; de-Groot N; Hochberg A; Vlodavsky I
Inhibition of bladder carcinoma angiogenesis, stromal support, and tumor growth by halofuginone.
Cancer research 1999;59(16):4111-8.
1999: Vlodavsky I; Friedmann Y; Elkin M; Aingorn H; Atzmon R; Ishai-Michaeli R; Bitan M; Pappo O; Peretz T; Michal I; Spector L; Pecker I
Mammalian heparanase: gene cloning, expression and function in tumor progression and metastasis.
Nature medicine 1999;5(7):793-802.
1999: Rechter M; Lider O; Cahalon L; Baharav E; Dekel M; Seigel D; Vlodavsky I; Aingorn H; Cohen I R; Shoseyov O
A cellulose-binding domain-fused recombinant human T cell connective tissue-activating peptide-III manifests heparanase activity.
Biochemical and biophysical research communications 1999;255(3):657-62.
1998: Hosokawa K; Aharoni D; Dantes A; Shaulian E; Schere-Levy C; Atzmon R; Kotsuji F; Oren M; Vlodavsky I; Amsterdam A
Modulation of Mdm2 expression and p53-induced apoptosis in immortalized human ovarian granulosa cells.
Endocrinology 1998;139(11):4688-700.
1998: Hosokawa K; Dantes A; Schere-Levy C; Barash A; Yoshida Y; Kotsuji F; Vlodavsky I; Amsterdam A
Induction of Ad4BP/SF-1, steroidogenic acute regulatory protein, and cytochrome P450scc enzyme system expression in newly established human granulosa cell lines.
Endocrinology 1998;139(11):4679-87.
1998: Even-Ram S; Uziely B; Cohen P; Grisaru-Granovsky S; Maoz M; Ginzburg Y; Reich R; Vlodavsky I; Bar-Shavit R
Thrombin receptor overexpression in malignant and physiological invasion processes.
Nature medicine 1998;4(8):909-14.
1998: Pikas D S; Li J P; Vlodavsky I; Lindahl U
Substrate specificity of heparanases from human hepatoma and platelets.
The Journal of biological chemistry 1998;273(30):18770-7.
1997: Nagler A; Katz A; Aingorn H; Miao H Q; Condiotti R; Genina O; Pines M; Vlodavsky I
Inhibition of glomerular mesangial cell proliferation and extracellular matrix deposition by halofuginone.
Kidney international 1997;52(6):1561-9.
1997: Schneider A; Chandra M; Lazarovici G; Vlodavsky I; Merin G; Uretzky G; Borman J B; Schwalb H
Naturally produced extracellular matrix is an excellent substrate for canine endothelial cell proliferation and resistance to shear stress on PTFE vascular grafts.
Thrombosis and haemostasis 1997;78(5):1392-8.
1997: Katz A; Vlodavsky I; Davies M; Miao H Q; Ben-Sasson S A; Darmon D; Hurwitz H; Borgel H; Benezra M
Antiproliferative activity to glomerular mesangial cells and receptor binding of a heparin-mimicking polyaromatic anionic compound.
Journal of the American Society of Nephrology : JASN 1997;8(11):1688-97.
1997: Bonneh-Barkay D; Shlissel M; Berman B; Shaoul E; Admon A; Vlodavsky I; Carey D J; Asundi V K; Reich-Slotky R; Ron D
Identification of glypican as a dual modulator of the biological activity of fibroblast growth factors.
The Journal of biological chemistry 1997;272(19):12415-21.
1997: Miao H Q; Ornitz D M; Aingorn E; Ben-Sasson S A; Vlodavsky I
Modulation of fibroblast growth factor-2 receptor binding, dimerization, signaling, and angiogenic activity by a synthetic heparin-mimicking polyanionic compound.
The Journal of clinical investigation 1997;99(7):1565-75.
1997: Medalion B; Merin G; Aingorn H; Miao H Q; Nagler A; Elami A; Ishai-Michaeli R; Vlodavsky I
Endogenous basic fibroblast growth factor displaced by heparin from the lumenal surface of human blood vessels is preferentially sequestered by injured regions of the vessel wall.
Circulation 1997;95(7):1853-62.
1997: Poltorak Z; Cohen T; Sivan R; Kandelis Y; Spira G; Vlodavsky I; Keshet E; Neufeld G
VEGF145, a secreted vascular endothelial growth factor isoform that binds to extracellular matrix.
The Journal of biological chemistry 1997;272(11):7151-8.
1997: Nagler A; Miao H Q; Aingorn H; Pines M; Genina O; Vlodavsky I
Inhibition of collagen synthesis, smooth muscle cell proliferation, and injury-induced intimal hyperplasia by halofuginone.
Arteriosclerosis, thrombosis, and vascular biology 1997;17(1):194-202.
1997: Aharoni D; Meiri I; Atzmon R; Vlodavsky I; Amsterdam A
Differential effect of components of the extracellular matrix on differentiation and apoptosis.
Current biology : CB 1997;7(1):43-51.
1996: Goshen R; Ariel I; Shuster S; Hochberg A; Vlodavsky I; de Groot N; Ben-Rafael Z; Stern R
Hyaluronan, CD44 and its variant exons in human trophoblast invasion and placental angiogenesis.
Molecular human reproduction 1996;2(9):685-91.
1996: Goshen R; Hochberg A A; Korner G; Levy E; Ishai-Michaeli R; Elkin M; de Groot N; Vlodavsky I
Purification and characterization of placental heparanase and its expression by cultured cytotrophoblasts.
Molecular human reproduction 1996;2(9):679-84.
1996: Levi E; Fridman R; Miao H Q; Ma Y S; Yayon A; Vlodavsky I
Matrix metalloproteinase 2 releases active soluble ectodomain of fibroblast growth factor receptor 1.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(14):7069-74.
1996: Vlodavsky I; Miao H Q; Medalion B; Danagher P; Ron D
Involvement of heparan sulfate and related molecules in sequestration and growth promoting activity of fibroblast growth factor.
Cancer metastasis reviews 1996;15(2):177-86.
1996: Sehayek E; Wang X X; Vlodavsky I; Avner R; Levkovitz H; Olivecrona T; Olivecrona G; Willnow T E; Herz J; Eisenberg S
Heparan sulfate-dependent and low density lipoprotein receptor-related protein-dependent catabolic pathways for lipoprotein lipase in mouse embryonic fibroblasts.
Israel journal of medical sciences 1996;32(6):449-54.
1996: Bar-Shavit R; Maoz M; Ginzburg Y; Vlodavsky I
Specific involvement of glypican in thrombin adhesive properties.
Journal of cellular biochemistry 1996;61(2):278-91.
1996: Miao H Q; Ishai-Michaeli R; Atzmon R; Peretz T; Vlodavsky I
Sulfate moieties in the subendothelial extracellular matrix are involved in basic fibroblast growth factor sequestration, dimerization, and stimulation of cell proliferation.
The Journal of biological chemistry 1996;271(9):4879-86.
1995: Hershkoviz R; Mor F; Miao H Q; Vlodavsky I; Lider O
Differential effects of polysulfated polysaccharide on experimental encephalomyelitis, proliferation of autoimmune T cells, and inhibition of heparanase activity.
Journal of autoimmunity 1995;8(5):741-50.
1995: Miao H Q; Ishai-Michaeli R; Peretz T; Vlodavsky I
Laminarin sulfate mimics the effects of heparin on smooth muscle cell proliferation and basic fibroblast growth factor-receptor binding and mitogenic activity.
Journal of cellular physiology 1995;164(3):482-90.
1995: Vlodavsky I; Miao H Q; Atzmon R; Levi E; Zimmermann J; Bar-Shavit R; Peretz T; Ben-Sasson S A
Control of cell proliferation by heparan sulfate and heparin-binding growth factors.
Thrombosis and haemostasis 1995;74(1):534-40.
1995: Gilat D; Hershkoviz R; Goldkorn I; Cahalon L; Korner G; Vlodavsky I; Lider O
Molecular behavior adapts to context: heparanase functions as an extracellular matrix-degrading enzyme or as a T cell adhesion molecule, depending on the local pH.
The Journal of experimental medicine 1995;181(5):1929-34.
1995: Sehayek E; Olivecrona T; Bengtsson-Olivecrona G; Vlodavsky I; Levkovitz H; Avner R; Eisenberg S
Binding to heparan sulfate is a major event during catabolism of lipoprotein lipase by HepG2 and other cell cultures.
Atherosclerosis 1995;114(1):1-8.
1995: Miao H Q; Fritz T A; Esko J D; Zimmermann J; Yayon A; Vlodavsky I
Heparan sulfate primed on beta-D-xylosides restores binding of basic fibroblast growth factor.
Journal of cellular biochemistry 1995;57(2):173-84.
1995: Bar-Shavit R; Ginzburg Y; Maoz M; Vlodavsky I; Peretz T
The involvement of thrombin RGD in metastasis: characterization of a cryptic adhesive site.
Israel journal of medical sciences 1995;31(2-3):86-94.
1994: Benezra M; Ben-Sasson S A; Regan J; Chang M; Bar-Shavit R; Vlodavsky I
Antiproliferative activity to vascular smooth muscle cells and receptor binding of heparin-mimicking polyaromatic anionic compounds.
Arteriosclerosis and thrombosis : a journal of vascular biology / American Heart Association 1994;14(12):1992-9.
1994: Gilat D; Hershkoviz R; Mekori Y A; Vlodavsky I; Lider O
Regulation of adhesion of CD4+ T lymphocytes to intact or heparinase-treated subendothelial extracellular matrix by diffusible or anchored RANTES and MIP-1 beta.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(11):4899-906.
1994: Soker S; Goldstaub D; Svahn C M; Vlodavsky I; Levi B Z; Neufeld G
Variations in the size and sulfation of heparin modulate the effect of heparin on the binding of VEGF165 to its receptors.
Biochemical and biophysical research communications 1994;203(2):1339-47.
1994: Aviezer D; Levy E; Safran M; Svahn C; Buddecke E; Schmidt A; David G; Vlodavsky I; Yayon A
Differential structural requirements of heparin and heparan sulfate proteoglycans that promote binding of basic fibroblast growth factor to its receptor.
The Journal of biological chemistry 1994;269(1):114-21.
1994: Vlodavsky I; Mohsen M; Lider O; Svahn C M; Ekre H P; Vigoda M; Ishai-Michaeli R; Peretz T
Inhibition of tumor metastasis by heparanase inhibiting species of heparin.
Invasion & metastasis 1994;14(1-6):290-302.
1993: Bar-Shavit R; Eskohjido Y; Fenton J W; Esko J D; Vlodavsky I
Thrombin adhesive properties: induction by plasmin and heparan sulfate.
The Journal of cell biology 1993;123(5):1279-87.
1993: Korner G; Deutsch V R; Vlodavsky I; Eldor A
Effects of ionizing irradiation on endothelial cell transglutaminase.
FEBS letters 1993;330(1):41-5.
1993: Benezra M; Vlodavsky I; Ishai-Michaeli R; Neufeld G; Bar-Shavit R
Thrombin-induced release of active basic fibroblast growth factor-heparan sulfate complexes from subendothelial extracellular matrix.
Blood 1993;81(12):3324-31.
1993: Korner G; Bjornsson T D; Vlodavsky I
Extracellular matrix produced by cultured corneal and aortic endothelial cells contains active tissue-type and urokinase-type plasminogen activators.
Journal of cellular physiology 1993;154(3):456-65.
1993: Hershkoviz R; Gilat D; Miron S; Mekori Y A; Aderka D; Wallach D; Vlodavsky I; Cohen I R; Lider O
Extracellular matrix induces tumour necrosis factor-alpha secretion by an interaction between resting rat CD4+ T cells and macrophages.
Immunology 1993;78(1):50-7.
1993: Schneider A; Schwalb H; Vlodavsky I; Uretzky G
An improved method of endothelial seeding on small caliber prosthetic vascular grafts coated with natural extracellular matrix.
Clinical materials 1993;13(1-4):51-5.
1993: Benezra M; Vlodavsky I; Bar-Shavit R
Prothrombin conversion to thrombin by plasminogen activator residing in the subendothelial extracellular matrix.
Seminars in thrombosis and hemostasis 1993;19(4):405-11.
1992: Eisenberg S; Sehayek E; Olivecrona T; Vlodavsky I
Lipoprotein lipase enhances binding of lipoproteins to heparan sulfate on cell surfaces and extracellular matrix.
The Journal of clinical investigation 1992;90(5):2013-21.
1992: Benezra M; Vlodavsky I; Yayon A; Bar-Shavit R; Regan J; Chang M; Ben-Sasson S
Reversal of basic fibroblast growth factor-mediated autocrine cell transformation by aromatic anionic compounds.
Cancer research 1992;52(20):5656-62.
1992: Benezra M; Vlodavsky I; Bar-Shavit R
Thrombin enhances degradation of heparan sulfate in the extracellular matrix by tumor cell heparanase.
Experimental cell research 1992;201(1):208-15.
1992: Matzner Y; Vlodavsky I; Bar-Ner M; Ishai-Michaeli R; Tauber A I
Subcellular localization of heparanase in human neutrophils.
Journal of leukocyte biology 1992;51(6):519-24.
1992: Schneider A; Melmed R N; Schwalb H; Karck M; Vlodavsky I; Uretzky G
An improved method for endothelial cell seeding on polytetrafluoroethylene small caliber vascular grafts.
Journal of vascular surgery : official publication, the Society for Vascular Surgery [and] International Society for Cardiovascular Surgery, North American Chapter 1992;15(4):649-56.
1992: Bashkin P; Neufeld G; Gitay-Goren H; Vlodavsky I
Release of cell surface-associated basic fibroblast growth factor by glycosylphosphatidylinositol-specific phospholipase C.
Journal of cellular physiology 1992;151(1):126-37.
1992: Gitay-Goren H; Soker S; Vlodavsky I; Neufeld G
The binding of vascular endothelial growth factor to its receptors is dependent on cell surface-associated heparin-like molecules.
The Journal of biological chemistry 1992;267(9):6093-8.
1992: Bar-Shavit R; Benezra M; Sabbah V; Bode W; Vlodavsky I
Thrombin as a multifunctional protein: induction of cell adhesion and proliferation.
American journal of respiratory cell and molecular biology 1992;6(2):123-30.
1992: Ishai-Michaeli R; Svahn C M; Weber M; Chajek-Shaul T; Korner G; Ekre H P; Vlodavsky I
Importance of size and sulfation of heparin in release of basic fibroblast growth factor from the vascular endothelium and extracellular matrix.
Biochemistry 1992;31(7):2080-8.
1992: Vlodavsky I; Eldor A; Haimovitz-Friedman A; Matzner Y; Ishai-Michaeli R; Lider O; Naparstek Y; Cohen I R; Fuks Z
Expression of heparanase by platelets and circulating cells of the immune system: possible involvement in diapedesis and extravasation.
Invasion & metastasis 1992;12(2):112-27.
1992: Vlodavsky I; Ishai-Michaeli R; Mohsen M; Bar-Shavit R; Catane R; Ekre H P; Svahn C M
Modulation of neovascularization and metastasis by species of heparin.
Advances in experimental medicine and biology 1992;313():317-27.
1991: Vlodavsky I; Bar-Shavit R; Ishai-Michaeli R; Bashkin P; Fuks Z
Extracellular sequestration and release of fibroblast growth factor: a regulatory mechanism?
Trends in biochemical sciences 1991;16(7):268-71.
1991: Vlodavsky I; Fuks Z; Ishai-Michaeli R; Bashkin P; Levi E; Korner G; Bar-Shavit R; Klagsbrun M
Extracellular matrix-resident basic fibroblast growth factor: implication for the control of angiogenesis.
Journal of cellular biochemistry 1991;45(2):167-76.
1991: Bar-Shavit R; Sabbah V; Lampugnani M G; Marchisio P C; Fenton J W; Vlodavsky I; Dejana E
An Arg-Gly-Asp sequence within thrombin promotes endothelial cell adhesion.
The Journal of cell biology 1991;112(2):335-44.
1991: Laskov R; Michaeli R I; Sharir H; Yefenof E; Vlodavsky I
Production of heparanase by normal and neoplastic murine B-lymphocytes.
International journal of cancer. Journal international du cancer 1991;47(1):92-8.
1991: Eldor A; Stromberg R R; Vlodavsky I; Hy-Am E; Koslow A R; Friedman L I; Levine R F
The effect of flow on the interaction of isolated megakaryocytes with subendothelial extracellular matrix.
Blood cells 1991;17(3):447-63; discussion 464-6.
1991: Vlodavsky I; Bashkin P; Ishai-Michaeli R; Chajek-Shaul T; Bar-Shavit R; Haimovitz-Friedman A; Klagsbrun M; Fuks Z
Sequestration and release of basic fibroblast growth factor.
Annals of the New York Academy of Sciences 1991;638():207-20.
1990: Vlodavsky I; Korner G; Ishai-Michaeli R; Bashkin P; Bar-Shavit R; Fuks Z
Extracellular matrix-resident growth factors and enzymes: possible involvement in tumor metastasis and angiogenesis.
Cancer metastasis reviews 1990;9(3):203-26.
1990: Resnick-Roguel N; Eldor A; Burstein H; Hy-Am E; Vlodavsky I; Panet A; Blajchman M A; Kotler M
Envelope glycoprotein of avian hemangioma retrovirus induces a thrombogenic surface on human and bovine endothelial cells.
Journal of virology 1990;64(8):4029-32.
1990: Matzner Y; Vlodavsky I; Michaeli R I; Eldor A
Selective inhibition of neutrophil activation by the subendothelial extracellular matrix: possible role in protection of the vessel wall during diapedesis.
Experimental cell research 1990;189(2):233-40.
1990: Peretz T; Antebi S U; Beller U; Horowitz A T; Fuks Z; Vlodavsky I
Maintenance on extracellular matrix and expression of heparanase activity by human ovarian carcinoma cells from biopsy specimens.
International journal of cancer. Journal international du cancer 1990;45(6):1054-60.
1990: Bashkin P; Razin E; Eldor A; Vlodavsky I
Degranulating mast cells secrete an endoglycosidase that degrades heparan sulfate in subendothelial extracellular matrix.
Blood 1990;75(11):2204-12.
1990: Bar-Shavit R; Benezra M; Eldor A; Hy-Am E; Fenton J W; Wilner G D; Vlodavsky I
Thrombin immobilized to extracellular matrix is a potent mitogen for vascular smooth muscle cells: nonenzymatic mode of action.
Cell regulation 1990;1(6):453-63.
1990: Lider O; Mekori Y A; Miller T; Bar-Tana R; Vlodavsky I; Baharav E; Cohen I R; Naparstek Y
Inhibition of T lymphocyte heparanase by heparin prevents T cell migration and T cell-mediated immunity.
European journal of immunology 1990;20(3):493-9.
1990: Chajek-Shaul T; Friedman G; Bengtsson-Olivecrona G; Vlodavsky I; Bar-Shavit R
Interaction of lipoprotein lipase with subendothelial extracellular matrix.
Biochimica et biophysica acta 1990;1042(2):168-75.
1990: Yedgar S; Vlodavsky I; Panet A; Reisfeld N; Eldor A
Interferon enhances phospholipase A2 activity in bovine aortic endothelial cells.
Eicosanoids 1990;3(4):225-9.
1989: Resnick-Roguel N; Burstein H; Hamburger J; Panet A; Eldor A; Vlodavsky I; Kotler M
Cytocidal effect caused by the envelope glycoprotein of a newly isolated avian hemangioma-inducing retrovirus.
Journal of virology 1989;63(10):4325-30.
1989: Eldor A; Vlodavsky I; Deutsch V; Levine R F
Megakaryocyte function and dysfunction.
Baillière's clinical haematology 1989;2(3):543-68.
1989: Eldor A; Vlodavsky I; Fuks Z; Matzner Y; Rubin D B
Arachidonic metabolism and radiation toxicity in cultures of vascular endothelial cells.
Prostaglandins, leukotrienes, and essential fatty acids 1989;36(4):251-8.
1989: Eldor A; Fuks Z; Matzner Y; Witte L D; Vlodavsky I
Perturbation of endothelial functions by ionizing irradiation: effects on prostaglandins, chemoattractants and mitogens.
Seminars in thrombosis and hemostasis 1989;15(2):215-25.
1989: Amsterdam A; Rotmensch S; Furman A; Venter E A; Vlodavsky I
Synergistic effect of human chorionic gonadotropin and extracellular matrix on in vitro differentiation of human granulosa cells: progesterone production and gap junction formation.
Endocrinology 1989;124(4):1956-64.
1989: Lider O; Baharav E; Mekori Y A; Miller T; Naparstek Y; Vlodavsky I; Cohen I R
Suppression of experimental autoimmune diseases and prolongation of allograft survival by treatment of animals with low doses of heparins.
The Journal of clinical investigation 1989;83(3):752-6.
1989: Bashkin P; Doctrow S; Klagsbrun M; Svahn C M; Folkman J; Vlodavsky I
Basic fibroblast growth factor binds to subendothelial extracellular matrix and is released by heparitinase and heparin-like molecules.
Biochemistry 1989;28(4):1737-43.
1988: Vlodavsky I; Michaeli R I; Bar-Ner M; Fridman R; Horowitz A T; Fuks Z; Biran S
Involvement of heparanase in tumor metastasis and angiogenesis.
Israel journal of medical sciences 1988;24(9-10):464-70.
1988: Krausz M M; Hartzstark Z; Shlomai Z; Gross D; Matzner Y; Eldor A; Vlodavsky I; Bassat H B
Decreased neutrophil thromboxane A2 and endothelial PGI2 production in the postoperative period. An in vitro assay for detection of neutrophil and plasma dysfunction.
Annals of surgery 1988;208(1):78-84.
1988: Spira O; Atzmon R; Rahamim E; Bar-Shavit R; Gross J; Gordon A; Vlodavsky I
Striated muscle fibers differentiate in primary cultures of adult anterior pituitary cells.
Endocrinology 1988;122(6):3002-4.
1988: Matzner Y; Cohn M; Hyam E; Razin E; Fuks Z; Buchanan M R; Haas T A; Vlodavsky I; Eldor A
Generation of lipid neutrophil chemoattractant by irradiated bovine aortic endothelial cells.
Journal of immunology (Baltimore, Md. : 1950) 1988;140(8):2681-5.
1988: Vlodavsky I; Eldor A; Bar-Ner M; Fridman R; Cohen I R; Klagsbrun M
Heparan sulfate degradation in tumor cell invasion and angiogenesis.
Advances in experimental medicine and biology 1988;233():201-10.
1987: Eldor A; Bar-Ner M; Yahalom J; Fuks Z; Vlodavsky I
Role of heparanase in platelet and tumor cell interactions with the subendothelial extracellular matrix.
Seminars in thrombosis and hemostasis 1987;13(4):475-88.
1987: Eldor A; Vlodavsky I; Riklis E; Fuks Z
Recovery of prostacyclin capacity of irradiated endothelial cells and the protective effect of vitamin C.
Prostaglandins 1987;34(2):241-55.
1987: Bar-Ner M; Eldor A; Wasserman L; Matzner Y; Cohen I R; Fuks Z; Vlodavsky I
Inhibition of heparanase-mediated degradation of extracellular matrix heparan sulfate by non-anticoagulant heparin species.
Blood 1987;70(2):551-7.
1987: Pode D; Horowitz A T; Vlodavsky I; Shapiro A; Biran S
Prevention of human bladder tumor cell implantation in an in vitro assay.
The Journal of urology 1987;137(4):777-81.
1987: Eldor A; Vlodavsky I; Heyns A D; Panet A
The effect and interactions of interferon and arachidonate products with vessel wall cells.
Progress in clinical and biological research 1987;242():323-8.
1986: Furman A; Rotmensch S; Dor J; Venter A; Mashiach S; Vlodavsky I; Amsterdam A
Culture of human granulosa cells from an in vitro fertilization program: effects of extracellular matrix on morphology and cyclic adenosine 3',5' monophosphate production.
Fertility and sterility 1986;46(3):514-7.
1986: Biran S; Vlodavsky I; Fuks Z; Lijovetzky G; Horowitz A T
Growth of human mammary carcinoma cells from biopsy specimens in serum-free medium on extracellular matrix.
International journal of cancer. Journal international du cancer 1986;38(3):345-54.
1986: Pode D; Alon Y; Horowitz A T; Vlodavsky I; Biran S
The mechanism of human bladder tumor implantation in an in vitro model.
The Journal of urology 1986;136(2):482-6.
1985: Matzner Y; Bar-Ner M; Yahalom J; Ishai-Michaeli R; Fuks Z; Vlodavsky I
Degradation of heparan sulfate in the subendothelial extracellular matrix by a readily released heparanase from human neutrophils. Possible role in invasion through basement membranes.
The Journal of clinical investigation 1985;76(4):1306-13.
1985: Fridman R; Alon Y; Doljanski F; Fuks Z; Vlodavsky I
Cell interaction with the extracellular matrices produced by endothelial cells and fibroblasts.
Experimental cell research 1985;158(2):461-76.
1985: Bar-Ner M; Kramer M D; Schirrmacher V; Ishai-Michaeli R; Fuks Z; Vlodavsky I
Sequential degradation of heparan sulfate in the subendothelial extracellular matrix by highly metastatic lymphoma cells.
International journal of cancer. Journal international du cancer 1985;35(4):483-91.
1984: Eldor A; Fridman R; Vlodavsky I; Hy-Am E; Fuks Z; Panet A
Interferon enhances prostacyclin production by cultured vascular endothelial cells.
The Journal of clinical investigation 1984;73(1):251-7.
1983: Biran S; Horowitz A T; Fuks Z; Vlodavsky I
High-density lipoprotein and extracellular matrix promotes growth and plating efficiency of normal human mammary epithelial cells in serum-free medium.
International journal of cancer. Journal international du cancer 1983;31(5):557-66.

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