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Andreas Vogt

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Anuradha Sehrawat; Su-Hyeong Kim; Andreas Vogt; Shivendra V Singh
Suppression of FOXQ1 in benzyl isothiocyanate-mediated inhibition of epithelial-mesenchymal transition in human breast cancer cells.
Yang Gao; Craig J Forsyth; Andreas Vogt; Kazunori Koide
Comparison of splicing factor 3b inhibitors in human cells.
Reety Arora; Jeffrey L Brodsky; Yuan Chang; Alexander Dömling; Huichen Feng; Anna Guastafierro; Daniel Normolle; MASAHIRO SHUDA; Yanis Tolstov; Tuna Toptan; Andreas Vogt; Laura L Vollmer; Patrick S Moore
Survivin is a therapeutic target in Merkel cell carcinoma.

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2013: Anuradha Sehrawat; Su-Hyeong Kim; Andreas Vogt; Shivendra V Singh
Suppression of FOXQ1 in benzyl isothiocyanate-mediated inhibition of epithelial-mesenchymal transition in human breast cancer cells.
Carcinogenesis 2013;34(4):864-73.
2013: Yang Gao; Craig J Forsyth; Andreas Vogt; Kazunori Koide
Comparison of splicing factor 3b inhibitors in human cells.
Chembiochem : a European journal of chemical biology 2013;14(1):49-52.
2012: Reety Arora; Jeffrey L Brodsky; Yuan Chang; Alexander Dömling; Huichen Feng; Anna Guastafierro; Daniel Normolle; MASAHIRO SHUDA; Yanis Tolstov; Tuna Toptan; Andreas Vogt; Laura L Vollmer; Patrick S Moore
Survivin is a therapeutic target in Merkel cell carcinoma.
Science translational medicine 2012;4(133):133ra56.
2011: Thomas C Farrell; Jong-Hyeon Jeong; Chiara Milanese; Andreas Vogt; Clinton L Cario; Edward A Burton
Evaluation of spontaneous propulsive movement as a screening tool to detect rescue of Parkinsonism phenotypes in zebrafish models.
Neurobiology of disease 2011;44(1):9-18.
2011: Manush Saydmohammed; Andreas Vogt; Laura L Vollmer; Ezenwa Obi Onuoha; Michael Tsang
A high-content screening assay in transgenic zebrafish identifies two novel activators of fgf signaling.
Birth defects research. Part C, Embryo today : reviews 2011;93(3):281-7.
2011: Laura L Vollmer; Wei Zhu; Raghavan Balachandran; Daniel P Camarco; Dennis P Curran; Hikmat N Daghestani; Billy W Day; Neil A Hukriede; Maria Jiménez; John Lazo; Celeste E Reese; Andreas Vogt
A simplified synthesis of novel dictyostatin analogues with in vitro activity against epothilone B-resistant cells and antiangiogenic activity in zebrafish embryos.
Molecular cancer therapeutics 2011;10(6):994-1006.
2011: María Jiménez; Andreas Vogt; Wei Zhu; Billy W Day; Dennis P Curran
Efficient syntheses of 25,26-dihydrodictyostatin and 25,26-dihydro-6-epi-dictyostatin, two potent new microtubule-stabilizing agents.
Beilstein journal of organic chemistry 2011;7():1372-8.
2010: Wei Zhu; María Jiménez; Won-Hyuk Jung; Daniel P Camarco; Raghavan Balachandran; Andreas Vogt; Billy W Day; Dennis P Curran
Streamlined syntheses of (-)-dictyostatin, 16-desmethyl-25,26-dihydrodictyostatin, and 6-epi-16-desmethyl-25,26-dihydrodictyostatin.
Journal of the American Chemical Society 2010;132(26):9175-87.
2010: John Lazo; Celeste E Reese; Andreas Vogt; Laura L Vollmer; Carolyn A Kitchens; Eckhard Günther; Thomas H Graham; Chad D Hopkins; Peter Wipf
Identifying a resistance determinant for the antimitotic natural products disorazole C1 and A1.
The Journal of pharmacology and experimental therapeutics 2010;332(3):906-11.
2010: Andreas Vogt; Hiba Codore; Billy W Day; Neil A Hukriede; Michael Tsang
Development of automated imaging and analysis for zebrafish chemical screens.
Journal of visualized experiments : JoVE 2010;(40):.
2009: Andreas Vogt; Peter A McPherson; Xiaoqiang Shen; Raghavan Balachandran; Guangyu Zhu; Brianne S Raccor; Scott G Nelson; Michael Tsang; Billy W Day
High-content analysis of cancer-cell-specific apoptosis and inhibition of in vivo angiogenesis by synthetic (-)-pironetin and analogs.
Chemical biology & drug design 2009;74(4):358-68.
2009: Gabriela Molina; Andreas Vogt; Ahmet Bakan; Weixiang Dai; Pierre Queiroz de Oliveira; Wade Znosko; Thomas E Smithgall; Ivet Bahar; John Lazo; Billy W Day; Michael Tsang
Zebrafish chemical screening reveals an inhibitor of Dusp6 that expands cardiac cell lineages.
Nature chemical biology 2009;5(9):680-7.
2009: Brian J Albert; Peter A McPherson; Kristine O'Brien; Nancy L Czaicki; Vincent Destefino; Sami Osman; Miaosheng Li; Billy W Day; Paula J Grabowski; Melissa J Moore; Andreas Vogt; Kazunori Koide
Meayamycin inhibits pre-messenger RNA splicing and exhibits picomolar activity against multidrug-resistant cells.
Molecular cancer therapeutics 2009;8(8):2308-18.
2009: Andreas Vogt; Andrzej Cholewinski; Xiaoqiang Shen; Scott G Nelson; John Lazo; Michael Tsang; Neil A Hukriede
Automated image-based phenotypic analysis in zebrafish embryos.
Developmental dynamics : an official publication of the American Association of Anatomists 2009;238(3):656-63.
2009: Huafei Zou; Sufi Thomas; Zhen-Wen Yan; Jennifer Rubin Grandis; Andreas Vogt; Lu-Yuan Li
Human rhomboid family-1 gene RHBDF1 participates in GPCR-mediated transactivation of EGFR growth signals in head and neck squamous cancer cells.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009;23(2):425-32.
2008: Brianne S Raccor; Andreas Vogt; Rachel Sikorski; Charitha Madiraju; Raghavan Balachandran; Kia Montgomery; Youseung Shin; Yoshikazu Fukui; Won-Hyuk Jung; Dennis P Curran; Billy W Day
Cell-based and biochemical structure-activity analyses of analogs of the microtubule stabilizer dictyostatin.
Molecular pharmacology 2008;73(3):718-26.
2008: Andreas Vogt; Peter R McDonald; Aletheia Tamewitz; Rachel Sikorski; Peter Wipf; John J Skoko; John Lazo
A cell-active inhibitor of mitogen-activated protein kinase phosphatases restores paclitaxel-induced apoptosis in dexamethasone-protected cancer cells.
Molecular cancer therapeutics 2008;7(2):330-40.
2007: Zhiyong Wang; Peter A McPherson; Brianne S Raccor; Raghavan Balachandran; Guangyu Zhu; Billy W Day; Andreas Vogt; Peter Wipf
Structure-activity and high-content imaging analyses of novel tubulysins.
Chemical biology & drug design 2007;70(2):75-86.
2007: Andreas Vogt; John Lazo
Implementation of high-content assay for inhibitors of mitogen-activated protein kinase phosphatases.
Methods (San Diego, Calif.) 2007;42(3):268-77.
2007: Won-Hyuk Jung; Cristian Harrison; Youseung Shin; Jean-Hugues Fournier; Raghavan Balachandran; Brianne S Raccor; Rachel Sikorski; Andreas Vogt; Dennis P Curran; Billy W Day
Total synthesis and biological evaluation of C16 analogs of (-)-dictyostatin.
Journal of medicinal chemistry 2007;50(13):2951-66.
2007: Andreas Vogt; John Lazo
Discovery of protein kinase phosphatase inhibitors.
Methods in molecular biology (Clifton, N.J.) 2007;356():389-400.
2006: John Lazo; Ruth Nunes; John J Skoko; Pierre Queiroz de Oliveira; Andreas Vogt; Peter Wipf
Novel benzofuran inhibitors of human mitogen-activated protein kinase phosphatase-1.
Bioorganic & medicinal chemistry 2006;14(16):5643-50.
2006: Junko Ohkanda; Corey L Strickland; Michelle A Blaskovich; Dora Carrico; Jeffrey W Lockman; Andreas Vogt; Cynthia J Bucher; Jiazhi Sun; Yimin Qian; David Knowles; Erin E Pusateri; Said M Sebti; Andrew D Hamilton
Structure-based design of imidazole-containing peptidomimetic inhibitors of protein farnesyltransferase.
Organic & biomolecular chemistry 2006;4(3):482-92.
2006: Peter Wipf; Thomas H Graham; Andreas Vogt; Rachel Sikorski; Alexander P Ducruet; John Lazo
Cellular analysis of disorazole C and structure-activity relationship of analogs of the natural product.
Chemical biology & drug design 2006;67(1):66-73.
2005: Charitha Madiraju; Michael Edler; Ernest Hamel; Brianne S Raccor; Raghavan Balachandran; Guangyu Zhu; Kenneth A Giuliano; Andreas Vogt; Youseung Shin; Jean-Hugues Fournier; Yoshikazu Fukui; Arndt M Brückner; Dennis P Curran; Billy W Day
Tubulin assembly, taxoid site binding, and cellular effects of the microtubule-stabilizing agent dictyostatin.
Biochemistry 2005;44(45):15053-63.
2005: Andreas Vogt; John Lazo
Chemical complementation: a definitive phenotypic strategy for identifying small molecule inhibitors of elusive cellular targets.
Pharmacology & therapeutics 2005;107(2):212-21.
2005: Andreas Vogt; Aletheia Tamewitz; John Skoko; Rachel Sikorski; Kenneth A Giuliano; John Lazo
The benzo[c]phenanthridine alkaloid, sanguinarine, is a selective, cell-active inhibitor of mitogen-activated protein kinase phosphatase-1.
The Journal of biological chemistry 2005;280(19):19078-86.
2005: Andreas Vogt; Peter Wipf; Marni Brisson; Kathleen A Cooley; Michael G Tarpley; John S Lazo
Cell-active dual specificity phosphatase inhibitors identified by high-content screening.
Drug discovery today 2005;Suppl():3-12.
2005: Alexander P Ducruet; Andreas Vogt; Peter Wipf; John Lazo
Dual specificity protein phosphatases: therapeutic targets for cancer and Alzheimer's disease.
Annual review of pharmacology and toxicology 2005;45():725-50.
2004: Marni Brisson; Theresa Nguyen; Andreas Vogt; Jack C Yalowich; Angela Giorgianni; Dror Tobi; Ivet Bahar; Corey R J Stephenson; Peter Wipf; John Lazo
Discovery and characterization of novel small molecule inhibitors of human Cdc25B dual specificity phosphatase.
Molecular pharmacology 2004;66(4):824-33.
2004: Andreas Vogt; Erica N Kalb; John Lazo
A scalable high-content cytotoxicity assay insensitive to changes in mitochondrial metabolic activity.
Oncology research 2004;14(6):305-14.
2003: Andreas Vogt; Kathleen A Cooley; Marni Brisson; Michael G Tarpley; Peter Wipf; John Lazo
Cell-active dual specificity phosphatase inhibitors identified by high-content screening.
Chemistry & biology 2003;10(8):733-42.
2002: Andreas Vogt; Katharine E Pestell; Billy W Day; John Lazo; Peter Wipf
The antisignaling agent SC-alpha alpha delta 9, 4-(benzyl-(2-[(2,5-diphenyloxazole-4-carbonyl)amino]ethyl)carbamoyl)- 2-decanoylaminobutyric acid, is a structurally unique phospholipid analogue with phospholipase C inhibitory activity.
Molecular cancer therapeutics 2002;1(11):885-92.
2001: John Lazo; DC Aslan; Eileen C Southwick; Kathleen A Cooley; Alexander P Ducruet; Beomjun Joo; Andreas Vogt; Peter Wipf
Discovery and biological evaluation of a new family of potent inhibitors of the dual specificity protein phosphatase Cdc25.
Journal of medicinal chemistry 2001;44(24):4042-9.
2001: Andreas Vogt; Takahito Adachi; Alexander P Ducruet; Jon Chesebrough; Kaoru Nemoto; Brian I Carr; John Lazo
Spatial analysis of key signaling proteins by high-content solid-phase cytometry in Hep3B cells treated with an inhibitor of Cdc25 dual-specificity phosphatases.
The Journal of biological chemistry 2001;276(23):20544-50.
2001: John Lazo; K Tamura; Andreas Vogt; JK Jung; S Rodriguez; Raghavan Balachandran; Billy W Day; Peter Wipf
Antimitotic actions of a novel analog of the fungal metabolite palmarumycin CP1.
The Journal of pharmacology and experimental therapeutics 2001;296(2):364-71.
2000: Andreas Vogt; K Tamura; S Watson; John Lazo
Antitumor imidazolyl disulfide IV-2 causes irreversible G(2)/M cell cycle arrest without hyperphosphorylation of cyclin-dependent kinase Cdk1.
The Journal of pharmacology and experimental therapeutics 2000;294(3):1070-5.
2000: Andreas Vogt; AS Wang; Candace S Johnson; James P Fabisiak; Peter Wipf; John Lazo
In vivo antitumor activity and induction of insulin-like growth factor-1-resistant apoptosis by SC-alphaalphadelta9.
The Journal of pharmacology and experimental therapeutics 2000;292(2):530-7.
1999: Yimin Qian; J J Marugan; R D Fossum; Andreas Vogt; Said M Sebti; Andrew D Hamilton
Probing the hydrophobic pocket of farnesyltransferase: aromatic substitution of CAAX peptidomimetics leads to highly potent inhibitors.
Bioorganic & medicinal chemistry 1999;7(12):3011-24.
1999: A Vasudevan; Yimin Qian; Andreas Vogt; Michelle A Blaskovich; Junko Ohkanda; Said M Sebti; Andrew D Hamilton
Potent, highly selective, and non-thiol inhibitors of protein geranylgeranyltransferase-I.
Journal of medicinal chemistry 1999;42(8):1333-40.
1998: Andreas Vogt; RL Rice; CE Settineri; F Yokokawa; S Yokokawa; Peter Wipf; John Lazo
Disruption of insulin-like growth factor-1 signaling and down-regulation of cdc2 by SC-alphaalphadelta9, a novel small molecule antisignaling agent identified in a targeted array library.
The Journal of pharmacology and experimental therapeutics 1998;287(2):806-13.
1998: Yimin Qian; Andreas Vogt; A Vasudevan; Said M Sebti; Andrew D Hamilton
Selective inhibition of type-I geranylgeranyltransferase in vitro and in whole cells by CAAL peptidomimetics.
Bioorganic & medicinal chemistry 1998;6(3):293-9.
1997: Andreas Vogt; J Sun; Yimin Qian; Andrew D Hamilton; Said M Sebti
The geranylgeranyltransferase-I inhibitor GGTI-298 arrests human tumor cells in G0/G1 and induces p21(WAF1/CIP1/SDI1) in a p53-independent manner.
The Journal of biological chemistry 1997;272(43):27224-9.
1996: Andreas Vogt; Yimin Qian; Terence F Mcguire; Andrew D Hamilton; Said M Sebti
Protein geranylgeranylation, not farnesylation, is required for the G1 to S phase transition in mouse fibroblasts.
Oncogene 1996;13(9):1991-9.
1996: Terence F Mcguire; Yimin Qian; Andreas Vogt; Andrew D Hamilton; Said M Sebti
Platelet-derived growth factor receptor tyrosine phosphorylation requires protein geranylgeranylation but not farnesylation.
The Journal of biological chemistry 1996;271(44):27402-7.
1996: Yimin Qian; Andreas Vogt; Said M Sebti; Andrew D Hamilton
Design and synthesis of non-peptide Ras CAAX mimetics as potent farnesyltransferase inhibitors.
Journal of medicinal chemistry 1996;39(1):217-23.
1995: R C Kauffmann; Yimin Qian; Andreas Vogt; Said M Sebti; Andrew D Hamilton; Richard W Carthew
Activated Drosophila Ras1 is selectively suppressed by isoprenyl transferase inhibitors.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(24):10919-23.
1995: E C Lerner; Yimin Qian; Michelle A Blaskovich; R D Fossum; Andreas Vogt; J Sun; Adrienne D Cox; Channing J Der; Andrew D Hamilton; Said M Sebti
Ras CAAX peptidomimetic FTI-277 selectively blocks oncogenic Ras signaling by inducing cytoplasmic accumulation of inactive Ras-Raf complexes.
The Journal of biological chemistry 1995;270(45):26802-6.
1995: Andreas Vogt; J Sun; Yimin Qian; E Tan-Chiu; Andrew D Hamilton; Said M Sebti
Burkitt lymphoma Daudi cells contain two distinct farnesyltransferases with different divalent cation requirements.
Biochemistry 1995;34(38):12398-403.
1995: Terence F Mcguire; Yimin Qian; Michelle A Blaskovich; R D Fossum; J Sun; T Marlowe; Seth J Corey; S P Wathen; Andreas Vogt; Andrew D Hamilton
CAAX peptidomimetic FTI-244 decreases platelet-derived growth factor receptor tyrosine phosphorylation levels and inhibits stimulation of phosphatidylinositol 3-kinase but not mitogen-activated protein kinase.
Biochemical and biophysical research communications 1995;214(1):295-303.
1995: Andreas Vogt; Yimin Qian; Michelle A Blaskovich; R D Fossum; Andrew D Hamilton; Said M Sebti
A non-peptide mimetic of Ras-CAAX: selective inhibition of farnesyltransferase and Ras processing.
The Journal of biological chemistry 1995;270(2):660-4.