FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Irene Volitakis

Research Profile

Chemicals & Drugs

Disorders

Living Beings

Anatomy

Procedures

Mass Spectrometry

Co-author Network

Publications

TOP 3
Jeffrey R Liddell; Joe Liu; Su San Mok; Daniel Obando; Irene Volitakis; Anthony R White; Peter J Crouch; George Ganio; Rachel Codd
Lipophilic adamantyl- or deferasirox-based conjugates of desferrioxamine B have enhanced neuroprotective capacity: implications for Parkinson disease.
Katja M Kanninen; Jodi Meyerowitz; David N Palmer; Sarah J Parker; Brett M Paterson; Imke Tammen; Jiang-Li Tan; Irene Volitakis; Peter J Crouch; Paul S Donnelly; Clare Duncan; Alexandra Grubman; James L Hickey; Anthony R White
Increased zinc and manganese in parallel with neurodegeneration, synaptic protein changes and activation of Akt/GSK3 signaling in ovine CLN6 neuronal ceroid lipofuscinosis.
Alan Rembach; Blaine R Roberts; Christopher C Rowe; Rebecca L Rumble; Brett O Trounson; Victor L Villemagne; Irene Volitakis; Andrew D Watt; William Wilson; James D Doecke; Kathryn A Ellis; Noel G Faux; Christopher J Fowler; Ralph N Martins; Colin L Masters; Kelly K Pertile; David Ames; Ashley I Bush
Longitudinal analysis of serum copper and ceruloplasmin in Alzheimer's disease.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Irene Volitakis (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2013: Jeffrey R Liddell; Joe Liu; Su San Mok; Daniel Obando; Irene Volitakis; Anthony R White; Peter J Crouch; George Ganio; Rachel Codd
Lipophilic adamantyl- or deferasirox-based conjugates of desferrioxamine B have enhanced neuroprotective capacity: implications for Parkinson disease.
Free radical biology & medicine 2013;60():147-56.
2013: Katja M Kanninen; Jodi Meyerowitz; David N Palmer; Sarah J Parker; Brett M Paterson; Imke Tammen; Jiang-Li Tan; Irene Volitakis; Peter J Crouch; Paul S Donnelly; Clare Duncan; Alexandra Grubman; James L Hickey; Anthony R White
Increased zinc and manganese in parallel with neurodegeneration, synaptic protein changes and activation of Akt/GSK3 signaling in ovine CLN6 neuronal ceroid lipofuscinosis.
PloS one 2013;8(3):e58644.
2013: Alan Rembach; Blaine R Roberts; Christopher C Rowe; Rebecca L Rumble; Brett O Trounson; Victor L Villemagne; Irene Volitakis; Andrew D Watt; William Wilson; James D Doecke; Kathryn A Ellis; Noel G Faux; Christopher J Fowler; Ralph N Martins; Colin L Masters; Kelly K Pertile; David Ames; Ashley I Bush
Longitudinal analysis of serum copper and ceruloplasmin in Alzheimer's disease.
Journal of Alzheimer's disease : JAD 2013;34(1):171-82.
2012: Peng Lei; Catriona A McLean; Blaine R Roberts; Loredana Spoerri; Irene Volitakis; Bruce X W Wong; David K Wright; Roberto Cappai; Robert A Cherny; Giuseppe D Ciccotosto; James A Duce; Gary F Egan; David I Finkelstein; Linh Q Lam; Paul A Adlard; Scott Ayton; Ashley I Bush
Tau deficiency induces parkinsonism with dementia by impairing APP-mediated iron export.
Nature medicine 2012;18(2):291-5.
2011: Katherine Ann Price; Irene Volitakis; Peter J Crouch; Paul S Donnelly; SinChun Lim; Brett M Paterson; Anthony R White
Mechanisms controlling the cellular accumulation of copper bis(thiosemicarbazonato) complexes.
Inorganic chemistry 2011;50(19):9594-605.
2011: Peter J Crouch; Paul S Donnelly; Mark A Greenough; Lin W Hung; Colin L Masters; Alexandra I Mot; Sarah J Parker; Maria S Savva; Irene Volitakis; Paul A Adlard; Kevin J Barnham; Ashley I Bush; Robert A Cherny; Anthony R White
The Alzheimer's therapeutic PBT2 promotes amyloid-β degradation and GSK3 phosphorylation via a metal chaperone activity.
Journal of neurochemistry 2011;119(1):220-30.
2011: Jonathan H Fox; Teal Connor; Megan Stiles; Jibrin Kama; Zhen Lu; Kathryn Dorsey; Gregory Liebermann; Ellen Sapp; Robert A Cherny; Mary Banks; Irene Volitakis; Marian DiFiglia; Oksana Berezovska; Ashley I Bush; Gregory Lieberman; Steven M Hersch
Cysteine oxidation within N-terminal mutant huntingtin promotes oligomerization and delays clearance of soluble protein.
The Journal of biological chemistry 2011;286(20):18320-30.
2011: David B Ascher; Brett A Cromer; Craig J Morton; Irene Volitakis; Robert A Cherny; Anthony L Albiston; Siew Yeen Chai; Michael W Parker
Regulation of insulin-regulated membrane aminopeptidase activity by its C-terminal domain.
Biochemistry 2011;50(13):2611-22.
2011: Mark A Greenough; Irene Volitakis; Qiao-Xin Li; Katrina Laughton; Genevieve Evin; Michael Ho; Andrew H Dalziel; James Camakaris; Ashley I Bush
Presenilins promote the cellular uptake of copper and zinc and maintain copper chaperone of SOD1-dependent copper/zinc superoxide dismutase activity.
The Journal of biological chemistry 2011;286(11):9776-86.
2010: Joo-Yong Lee; Eunsil Cho; Tae-Youn Kim; Dong-Kyu Kim; Richard D Palmiter; Irene Volitakis; Jong S Kim; Ashley I Bush; Jae-Young Koh
Apolipoprotein E ablation decreases synaptic vesicular zinc in the brain.
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 2010;23(6):1085-95.
2010: Marcus Brazier; Irene Volitakis; Magda Kvasnicka; Anthony R White; John R Underwood; Jason E Green; Sen Han; Andrew Hill; Colin L Masters; Steven J Collins
Manganese chelation therapy extends survival in a mouse model of M1000 prion disease.
Journal of neurochemistry 2010;114(2):440-51.
2009: Katherine Ann Price; Aphrodite Caragounis; Brett M Paterson; Gulay Filiz; Irene Volitakis; Colin L Masters; Kevin J Barnham; Paul S Donnelly; Peter J Crouch; Anthony R White
Sustained activation of glial cell epidermal growth factor receptor by bis(thiosemicarbazonato) metal complexes is associated with inhibition of protein tyrosine phosphatase activity.
Journal of medicinal chemistry 2009;52(21):6606-20.
2009: Lis A Evered; Brendan S Silbert; David A Scott; Paul Maruff; Katrina M Laughton; Irene Volitakis; Tiffany Cowie; Robert A Cherny; Colin L Masters; Qiao-Xin Li
Plasma amyloid beta42 and amyloid beta40 levels are associated with early cognitive dysfunction after cardiac surgery.
The Annals of thoracic surgery 2009;88(5):1426-32.
2009: Ya Hui Hung; Elysia L Robb; Irene Volitakis; Michael Ho; Genevieve Evin; Qiao-Xin Li; Janetta G Culvenor; Colin L Masters; Robert A Cherny; Ashley I Bush
Paradoxical condensation of copper with elevated beta-amyloid in lipid rafts under cellular copper deficiency conditions: implications for Alzheimer disease.
The Journal of biological chemistry 2009;284(33):21899-907.
2009: Christa J Maynard; Roberto Cappai; Irene Volitakis; Katrina M Laughton; Colin L Masters; Ashley I Bush; Qiao-Xin Li
Chronic exposure to high levels of zinc or copper has little effect on brain metal homeostasis or Abeta accumulation in transgenic APP-C100 mice.
Cellular and molecular neurobiology 2009;29(5):757-67.
2009: Dorothea Strozyk; Lenore J Launer; Paul A Adlard; Robert A Cherny; Andrew Tsatsanis; Irene Volitakis; Kaj Blennow; Helen Petrovitch; Lon R White; Ashley I Bush
Zinc and copper modulate Alzheimer Abeta levels in human cerebrospinal fluid.
Neurobiology of aging 2009;30(7):1069-77.
2009: Peter J Crouch; Lin Wai Hung; Paul A Adlard; Mikhalina Cortes; Varsha Lal; Gulay Filiz; Keyla Perez; Milawaty Nurjono; Aphrodite Caragounis; Tai Du; Katrina Laughton; Irene Volitakis; Ashley I Bush; Qiao-Xin Li; Colin L Masters; Roberto Cappai; Robert A Cherny; Paul S Donnelly; Anthony R White; Kevin J Barnham
Increasing Cu bioavailability inhibits Abeta oligomers and tau phosphorylation.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(2):381-6.
2009: Alicia N Minniti; Carlos Opazo; Daniela L Rebolledo; Irene Volitakis; Rebeca Aldunate; Ashley I Bush; Robert A Cherny; Ricardo Fadic; Paula M Grez; Colin Masters; Nibaldo C Inestrosa
Intracellular amyloid formation in muscle cells of Abeta-transgenic Caenorhabditis elegans: determinants and physiological role in copper detoxification.
Molecular neurodegeneration 2009;4():2.
2008: Paul A Adlard; Robert A Cherny; David Finkelstein; Elisabeth Gautier; Elysia Robb; Mikhalina Cortes; Irene Volitakis; Xiang Liu; Jeffrey P Smith; Keyla Perez; Katrina Laughton; Qiao-Xin Li; Susan A Charman; Joseph A Nicolazzo; Simon Wilkins; Karolina Deleva; Toni Lynch; Gaik Kok; Craig W Ritchie; Rudolph E Tanzi; Roberto Cappai; Colin L Masters; Kevin J Barnham; Ashley I Bush
Rapid restoration of cognition in Alzheimer's transgenic mice with 8-hydroxy quinoline analogs is associated with decreased interstitial Abeta.
Neuron 2008;59(1):43-55.
2008: Michael A Cater; Kelly T McInnes; Qiao-Xin Li; Irene Volitakis; Sharon La Fontaine; Julian F B Mercer; Ashley I Bush
Intracellular copper deficiency increases amyloid-beta secretion by diverse mechanisms.
The Biochemical journal 2008;412(1):141-52.
2008: Kevin J Barnham; Vijaya Kenche; Giuseppe D Ciccotosto; David P Smith; Deborah J Tew; Xiang Liu; Keyla Perez; Greg A Cranston; Timothy J Johanssen; Irene Volitakis; Ashley I Bush; Colin L Masters; Anthony R White; Jeffrey P Smith; Robert A Cherny; Roberto Cappai
Platinum-based inhibitors of amyloid-beta as therapeutic agents for Alzheimer's disease.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(19):6813-8.
2008: Tai Du; Sharon L La Fontaine; Michael Abdo; Shayne A Bellingham; Mark Greenough; Irene Volitakis; Robert A Cherny; Ashley I Bush; Peter J Hudson; James Camakaris; Julian F B Mercer; Peter J Crouch; Colin L Masters; Victoria M Perreau; Anthony R White
Investigating copper-regulated protein expression in Menkes fibroblasts using antibody microarrays.
Proteomics 2008;8(9):1819-31.
2008: Robert A Colvin; Ashley I Bush; Irene Volitakis; Charles P Fontaine; Dustin Thomas; Kazuya Kikuchi; William R Holmes
Insights into Zn2+ homeostasis in neurons from experimental and modeling studies.
American journal of physiology. Cell physiology 2008;294(3):C726-42.
2008: Paul S Donnelly; Aphrodite Caragounis; Tai Du; Katrina M Laughton; Irene Volitakis; Robert A Cherny; Robyn A Sharples; Andrew Hill; Qiao-Xin Li; Colin L Masters; Kevin J Barnham; Anthony R White
Selective intracellular release of copper and zinc ions from bis(thiosemicarbazonato) complexes reduces levels of Alzheimer disease amyloid-beta peptide.
The Journal of biological chemistry 2008;283(8):4568-77.
2007: Aphrodite Caragounis; Tai Du; Gulay Filiz; Katrina M Laughton; Irene Volitakis; Robyn A Sharples; Robert A Cherny; Colin L Masters; Simon C Drew; Andrew Hill; Qiao-Xin Li; Peter J Crouch; Kevin J Barnham; Anthony R White
Differential modulation of Alzheimer's disease amyloid beta-peptide accumulation by diverse classes of metal ligands.
The Biochemical journal 2007;407(3):435-50.
2007: Simon Melov; Paul A Adlard; Karl J Morten; Felicity Johnson; Tamara R Golden; Douglas Hinerfeld; Birgit Schilling; Christine Mavros; Colin L Masters; Irene Volitakis; Qiao-Xin Li; Katrina Laughton; Alan Hubbard; Robert A Cherny; Bradford Gibson; Ashley I Bush
Mitochondrial oxidative stress causes hyperphosphorylation of tau.
PloS one 2007;2(6):e536.
2007: Jonathan H Fox; Jibrin A Kama; Gregory Lieberman; Raman Chopra; Kate Dorsey; Vanita Chopra; Irene Volitakis; Robert A Cherny; Ashley I Bush; Steven M Hersch
Mechanisms of copper ion mediated Huntington's disease progression.
PloS one 2007;2(3):e334.
2007: J Caine; Irene Volitakis; Robert A Cherny; J Varghese; Ian Macreadie
Abeta produced as a fusion to maltose binding protein can be readily purified and stably associates with copper and zinc.
Protein and peptide letters 2007;14(1):83-6.
2006: D Religa; Dorothea Strozyk; Robert A Cherny; Irene Volitakis; Vahram Haroutunian; Bengt Winblad; J Naslund; Ashley I Bush
Elevated cortical zinc in Alzheimer disease.
Neurology 2006;67(1):69-75.
2006: Anthony R White; Tai Du; Katrina M Laughton; Irene Volitakis; Robyn A Sharples; Michel E Xilinas; David E Hoke; R. M. Damian Holsinger; Geneviève Evin; Robert A Cherny; Andrew Hill; Kevin J Barnham; Qiao-Xin Li; Ashley I Bush; Colin L Masters
Degradation of the Alzheimer disease amyloid beta-peptide by metal-dependent up-regulation of metalloprotease activity.
The Journal of biological chemistry 2006;281(26):17670-80.
2006: Christa Maynard; Roberto Cappai; Irene Volitakis; Robert A Cherny; Colin L Masters; Qiao-Xin Li; Ashley I Bush
Gender and genetic background effects on brain metal levels in APP transgenic and normal mice: implications for Alzheimer beta-amyloid pathology.
Journal of inorganic biochemistry 2006;100(5-6):952-62.
2006: Qiao-Xin Li; Su San Mok; Katrina M Laughton; Catriona A McLean; Irene Volitakis; Robert A Cherny; Nam Sang Cheung; Anthony R White; Colin L Masters
Overexpression of Abeta is associated with acceleration of onset of motor impairment and superoxide dismutase 1 aggregation in an amyotrophic lateral sclerosis mouse model.
Aging cell 2006;5(2):153-65.
2006: Carlos Opazo; Sandra Luza; Victor L Villemagne; Irene Volitakis; Christopher C Rowe; Kevin J Barnham; Dorothea Strozyk; Colin L Masters; Robert A Cherny; Ashley I Bush
Radioiodinated clioquinol as a biomarker for beta-amyloid: Zn complexes in Alzheimer's disease.
Aging cell 2006;5(1):69-79.
2005: Ambreena Siddiq; Issam Ayoub; Juan C Chavez; Leila Aminova; Sapan Shah; Joseph C LaManna; Stephanie M Patton; James Connor; Robert A Cherny; Irene Volitakis; Ashley I Bush; Ingrid Langsetmo; Todd Seeley; Volkmar Gunzler; Rajiv R Ratan
Hypoxia-inducible factor prolyl 4-hydroxylase inhibition. A target for neuroprotection in the central nervous system.
The Journal of biological chemistry 2005;280(50):41732-43.
2004: Mahmoud Kiaei; Ashley I Bush; BRETT MORRISON; John H Morrison; Robert A Cherny; Irene Volitakis; M Flint Beal; Jon W Gordon
Genetically decreased spinal cord copper concentration prolongs life in a transgenic mouse model of amyotrophic lateral sclerosis.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(36):7945-50.
2004: Avi Friedlich; Joo-Yong Lee; Thomas van Groen; Robert A Cherny; Irene Volitakis; Toby B Cole; Richard D Palmiter; Jae-Young Koh; Ashley I Bush
Neuronal zinc exchange with the blood vessel wall promotes cerebral amyloid angiopathy in an animal model of Alzheimer's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(13):3453-9.
2003: Craig W Ritchie; Ashley I Bush; Andrew Mackinnon; Stephen Macfarlane; Maree Mastwyk; Lachlan MacGregor; Lyn Kiers; Robert A Cherny; Qiao-Xin Li; Amanda Tammer; Darryl Carrington; Christine Mavros; Irene Volitakis; Michel E Xilinas; David Ames; Stephen Davis; Konrad Beyreuther; Rudolph E Tanzi; Colin L Masters
Metal-protein attenuation with iodochlorhydroxyquin (clioquinol) targeting Abeta amyloid deposition and toxicity in Alzheimer disease: a pilot phase 2 clinical trial.
Archives of neurology 2003;60(12):1685-91.
2003: Kevin J Barnham; Giuseppe D Ciccotosto; Anna K Tickler; Feda E Ali; Danielle G Smith; Nicholas A Williamson; Yuen-Han Lam; Darryl Carrington; Deborah J Tew; Gulcan Kocak; Irene Volitakis; Frances Separovic; Colin J Barrow; John D Wade; Colin L Masters; Robert A Cherny; Cyril C Curtain; Ashley I Bush; Roberto Cappai
Neurotoxic, redox-competent Alzheimer's beta-amyloid is released from lipid membrane by methionine oxidation.
The Journal of biological chemistry 2003;278(44):42959-65.
2002: Christa Maynard; Roberto Cappai; Irene Volitakis; Robert A Cherny; Anthony R White; Konrad Beyreuther; Colin L Masters; Ashley I Bush; Qiao-Xin Li
Overexpression of Alzheimer's disease amyloid-beta opposes the age-dependent elevations of brain copper and iron.
The Journal of biological chemistry 2002;277(47):44670-6.
2001: Michael F Jobling; Xudong Huang; Leanne R Stewart; Kevin J Barnham; Cyril C Curtain; Irene Volitakis; Matthew A Perugini; Anthony R White; Robert A Cherny; Colin L Masters; Colin J Barrow; Steven J Collins; Ashley I Bush; Roberto Cappai
Copper and zinc binding modulates the aggregation and neurotoxic properties of the prion peptide PrP106-126.
Biochemistry 2001;40(27):8073-84.
2001: Cyril C Curtain; F Ali; Irene Volitakis; Robert A Cherny; Raymond S Norton; Konrad Beyreuther; Colin J Barrow; Colin L Masters; Ashley I Bush; Kevin J Barnham
Alzheimer's disease amyloid-beta binds copper and zinc to generate an allosterically ordered membrane-penetrating structure containing superoxide dismutase-like subunits.
The Journal of biological chemistry 2001;276(23):20466-73.
2001: Robert A Cherny; Craig S Atwood; Michel E Xilinas; D N Gray; Walton D Jones; Catriona A McLean; Kevin J Barnham; Irene Volitakis; Fiona Fraser; Y Kim; Xudong Huang; Lee E Goldstein; Robert D. Moir; JT Lim; Konrad Beyreuther; Hui Zheng; Rudolph E Tanzi; Colin L Masters; Ashley I Bush
Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice.
Neuron 2001;30(3):665-76.
2000: Robert A Cherny; Kevin J Barnham; T Lynch; Irene Volitakis; Qiao-Xin Li; Catriona A McLean; Gerd Multhaup; Konrad Beyreuther; Rudolph E Tanzi; Colin L Masters; Ashley I Bush
Chelation and intercalation: complementary properties in a compound for the treatment of Alzheimer's disease.
Journal of structural biology 2000;130(2-3):209-16.