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Harald von Boehmer

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Harald von Boehmer; Carolin Daniel
Therapeutic opportunities for manipulating T(Reg) cells in autoimmunity and cancer.
Taras Kreslavsky; Masaki Miyazaki; Cornelis Murre; Piotr Sicinski; Yoon Choi; Etienne Gagnon; Michael Gleimer; Harald von Boehmer
β-Selection-induced proliferation is required for αβ T cell differentiation.
Yoon Jong Choi; Amanda L Christie; Per Hydbring; Andrew L Kung; Xiaoyu Li; A Thomas Look; Takaomi Sanda; Sabina Signoretti; Joanna Stefano; Harald von Boehmer; Piotr Sicinski
The requirement for cyclin D function in tumor maintenance.

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All Publications

2013: Harald von Boehmer; Carolin Daniel
Therapeutic opportunities for manipulating T(Reg) cells in autoimmunity and cancer.
Nature reviews. Drug discovery 2013;12(1):51-63.
2012: Taras Kreslavsky; Masaki Miyazaki; Cornelis Murre; Piotr Sicinski; Yoon Choi; Etienne Gagnon; Michael Gleimer; Harald von Boehmer
β-Selection-induced proliferation is required for αβ T cell differentiation.
Immunity 2012;37(5):840-53.
2012: Yoon Jong Choi; Amanda L Christie; Per Hydbring; Andrew L Kung; Xiaoyu Li; A Thomas Look; Takaomi Sanda; Sabina Signoretti; Joanna Stefano; Harald von Boehmer; Piotr Sicinski
The requirement for cyclin D function in tumor maintenance.
Cancer cell 2012;22(4):438-51.
2012: Susan M Schlenner; Youhai Chen; Qingguo Ruan; Benno Weigmann; Harald von Boehmer
Smad3 binding to the foxp3 enhancer is dispensable for the development of regulatory T cells with the exception of the gut.
The Journal of experimental medicine 2012;209(9):1529-35.
2012: Michael Gleimer; Harald von Boehmer; Taras Kreslavsky
PLZF Controls the Expression of a Limited Number of Genes Essential for NKT Cell Function.
Frontiers in immunology 2012;3():374.
2011: Carolin Daniel; Harald von Boehmer
Extra-thymically induced regulatory T cells: do they have potential in disease prevention?
Seminars in immunology 2011;23(6):410-7.
2011: Carolin Daniel; Roderick Bronson; Benno Weigmann; Harald von Boehmer
Prevention of type 1 diabetes in mice by tolerogenic vaccination with a strong agonist insulin mimetope.
The Journal of experimental medicine 2011;208(7):1501-10.
2011: Xiaoyu Li; Takaomi Sanda; A Thomas Look; Carl D Novina; Harald von Boehmer
Repression of tumor suppressor miR-451 is essential for NOTCH1-induced oncogenesis in T-ALL.
The Journal of experimental medicine 2011;208(4):663-75.
2011: Carolin Daniel; Harald von Boehmer
Extrathymic generation of regulatory T cells--chances and challenges for prevention of autoimmune disease.
Advances in immunology 2011;112():177-213.
2011: Carolin Daniel; Hidde Ploegh; Harald von Boehmer
Antigen-specific induction of regulatory T cells in vivo and in vitro.
Methods in molecular biology (Clifton, N.J.) 2011;707():173-85.
2010: Taras Kreslavsky; Michael Gleimer; Annette I Garbe; Harald von Boehmer
αβ versus γδ fate choice: counting the T-cell lineages at the branch point.
Immunological reviews 2010;238(1):169-81.
2010: Joel N H Stern; Derin B Keskin; Zenichiro Kato; Hanspeter Waldner; Sonja Schallenberg; Ana Anderson; Harald von Boehmer; Karsten Kretschmer; Jack L Strominger
Promoting tolerance to proteolipid protein-induced experimental autoimmune encephalomyelitis through targeting dendritic cells.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(40):17280-5.
2010: Carolin Daniel; Kerstin Wennhold; Hye-Jung Kim; Harald von Boehmer
Enhancement of antigen-specific Treg vaccination in vivo.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(37):16246-51.
2010: Taras Kreslavsky; Harald von Boehmer
gammadeltaTCR ligands and lineage commitment.
Seminars in immunology 2010;22(4):214-21.
2010: Matthias Merkenschlager; Harald von Boehmer
PI3 kinase signalling blocks Foxp3 expression by sequestering Foxo factors.
The Journal of experimental medicine 2010;207(7):1347-50.
2010: Michael Gleimer; Harald von Boehmer
Thymocyte selection: chemokine signaling is not only about the destination.
Current biology : CB 2010;20(7):R316-8.
2010: Taras Kreslavsky; Michael Gleimer; Harald von Boehmer
Alphabeta versus gammadelta lineage choice at the first TCR-controlled checkpoint.
Current opinion in immunology 2010;22(2):185-92.
2010: Markus Feuerer; Jonathan A Hill; Karsten Kretschmer; Harald von Boehmer; Diane Mathis; Christophe Benoist
Genomic definition of multiple ex vivo regulatory T cell subphenotypes.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(13):5919-24.
2010: Takaomi Sanda; Xiaoyu Li; Alejandro Gutierrez; Yebin Ahn; Donna S Neuberg; Jennifer O'Neil; Peter R Strack; Christopher G Winter; Stuart S Winter; Richard Larson; Harald von Boehmer; A Thomas Look
Interconnecting molecular pathways in the pathogenesis and drug sensitivity of T-cell acute lymphoblastic leukemia.
Blood 2010;115(9):1735-45.
2010: Namita Saran; Marcin Łyszkiewicz; Jens Pommerencke; Katrin Witzlau; Ramin Vakilzadeh; Matthias Ballmaier; Harald von Boehmer; Andreas Krueger
Multiple extrathymic precursors contribute to T-cell development with different kinetics.
Blood 2010;115(6):1137-44.
2010: Harald von Boehmer; Herman Waldmann
Immunological tolerance.
Frontiers in immunology 2010;1():102.
2010: Harald von Boehmer; Fritz Melchers
Checkpoints in lymphocyte development and autoimmune disease.
Nature immunology 2010;11(1):14-20.
2009: Jide Tian; Hoa Dang; Harald von Boehmer; Elmar Jaeckel; Daniel L Kaufman
Transgenically induced GAD tolerance curtails the development of early beta-cell autoreactivities but causes the subsequent development of supernormal autoreactivities to other beta-cell antigens.
Diabetes 2009;58(12):2843-50.
2009: Jens Nolting; Carolin Daniel; Sabine Reuter; Christina Stuelten; Peng Li; Henry Sucov; Byung-Gyu Kim; John J Letterio; Karsten Kretschmer; Hye-Jung Kim; Harald von Boehmer
Retinoic acid can enhance conversion of naive into regulatory T cells independently of secreted cytokines.
The Journal of experimental medicine 2009;206(10):2131-9.
2009: Zhuoxiao Cao; Akm Khyrul Wara; Basak Icli; Xinghui Sun; René R S Packard; Fehim Esen; Christopher J Stapleton; Malayannan Subramaniam; Karsten Kretschmer; Irina Apostolou; Harald von Boehmer; Göran K Hansson; Thomas C Spelsberg; Peter Libby; Mark W Feinberg
Kruppel-like factor KLF10 targets transforming growth factor-beta1 to regulate CD4(+)CD25(-) T cells and T regulatory cells.
The Journal of biological chemistry 2009;284(37):24914-24.
2009: Harald von Boehmer
Central tolerance: essential for preventing autoimmune disease?
European journal of immunology 2009;39(9):2313-6.
2009: Taras Kreslavsky; Adam K Savage; Robin Hobbs; Fotini Gounari; Roderick Bronson; Pablo Pereira; Pier Paolo Pandolfi; Albert Bendelac; Harald von Boehmer
TCR-inducible PLZF transcription factor required for innate phenotype of a subset of gammadelta T cells with restricted TCR diversity.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(30):12453-8.
2009: Carolin Daniel; Jens Nolting; Harald von Boehmer
Mechanisms of self-nonself discrimination and possible clinical relevance.
Immunotherapy 2009;1(4):631-44.
2009: Claude Saint-Ruf; Katharina Ungewiss; Marcus Groettrup; Ludovica Bruno; Hans Joerg Fehling; Harald von Boehmer
Analysis and expression of a cloned pre-T cell receptor gene. Science. 1994. 266: 1208-1212.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(9):5165-9.
2009: Harald von Boehmer
Notch 1 keeps pro-T cells on track.
Immunity 2009;30(1):5-7.
2008: Xiaoyu Li; Fotini Gounari; Alexei Protopopov; Khashayarsha Khazaie; Harald von Boehmer
Oncogenesis of T-ALL and nonmalignant consequences of overexpressing intracellular NOTCH1.
The Journal of experimental medicine 2008;205(12):2851-61.
2008: Irina Apostolou; Panos Verginis; Karsten Kretschmer; Julia Polansky; Jochen Hühn; Harald von Boehmer
Peripherally induced Treg: mode, stability, and role in specific tolerance.
Journal of clinical immunology 2008;28(6):619-24.
2008: Julia K Polansky; Karsten Kretschmer; Jennifer Freyer; Stefan Floess; Annette Garbe; Udo Baron; Sven Olek; Alf Hamann; Harald von Boehmer; Jochen Huehn
DNA methylation controls Foxp3 gene expression.
European journal of immunology 2008;38(6):1654-63.
2008: Harald von Boehmer
Positive and negative selection in Basel.
Nature immunology 2008;9(6):571-3.
2008: Taras Kreslavsky; Annette I Garbe; Andreas Krueger; Harald von Boehmer
T cell receptor-instructed alphabeta versus gammadelta lineage commitment revealed by single-cell analysis.
The Journal of experimental medicine 2008;205(5):1173-86.
2008: Klaus Rajewsky; Harald von Boehmer
Lymphocyte development: overview.
Current opinion in immunology 2008;20(2):127-30.
2008: Fay C Magnusson; Roland S Liblau; Harald von Boehmer; Mikaël J Pittet; Je-Wook Lee; Shannon Turley; Khashayarsha Khazaie
Direct presentation of antigen by lymph node stromal cells protects against CD8 T-cell-mediated intestinal autoimmunity.
Gastroenterology 2008;134(4):1028-37.
2008: Panayotis Verginis; Katherine McLaughlin; Kai W Wucherpfennig; Harald von Boehmer; Irina Apostolou
Induction of antigen-specific regulatory T cells in wild-type mice: visualization and targets of suppression.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(9):3479-84.
2008: Harald von Boehmer; Jens Nolting
What turns on Foxp3?
Nature immunology 2008;9(2):121-2.
2008: Karsten Kretschmer; Irina Apostolou; Panos Verginis; Harald von Boehmer
Regulatory T cells and antigen-specific tolerance.
Chemical immunology and allergy 2008;94():8-15.
2008: Takeshi Egawa; Taras Kreslavsky; Dan R Littman; Harald von Boehmer
Lineage diversion of T cell receptor transgenic thymocytes revealed by lineage fate mapping.
PloS one 2008;3(1):e1512.
2007: Magali Fasseu; Peter D Aplan; Martine Chopin; Nicolas Boissel; Jean-Christophe Bories; Jean Soulier; Harald von Boehmer; François Sigaux; Armelle Regnault
p16INK4A tumor suppressor gene expression and CD3epsilon deficiency but not pre-TCR deficiency inhibit TAL1-linked T-lineage leukemogenesis.
Blood 2007;110(7):2610-9.
2007: Harald von Boehmer
Oral tolerance: is it all retinoic acid?
The Journal of experimental medicine 2007;204(8):1737-9.
2007: Zhuyan Guo; Marei Dose; Damian Kovalovsky; Rui Chang; Jennifer O'Neil; A Thomas Look; Harald von Boehmer; Khashayarsha Khazaie; Fotini Gounari
Beta-catenin stabilization stalls the transition from double-positive to single-positive stage and predisposes thymocytes to malignant transformation.
Blood 2007;109(12):5463-72.
2007: Avinash Bhandoola; Harald von Boehmer; Howard T Petrie; Juan Carlos Zúñiga-Pflücker
Commitment and developmental potential of extrathymic and intrathymic T cell precursors: plenty to choose from.
Immunity 2007;26(6):678-89.
2007: Annette I Garbe; Harald von Boehmer
TCR and Notch synergize in alphabeta versus gammadelta lineage choice.
Trends in immunology 2007;28(3):124-31.
2007: Alexander Marson; Karsten Kretschmer; Garrett M Frampton; Elizabeth S Jacobsen; Julia K Polansky; Kenzie D Macisaac; Stuart S Levine; Ernest Fraenkel; Harald von Boehmer; Richard A Young
Foxp3 occupancy and regulation of key target genes during T-cell stimulation.
Nature 2007;445(7130):931-5.
2007: Andreas Krueger; Harald von Boehmer
Identification of a T lineage-committed progenitor in adult blood.
Immunity 2007;26(1):105-16.
2006: Harald von Boehmer
Can studies of tolerance ever lead to therapy?
Annals of the rheumatic diseases 2006;65 Suppl 3():iii41-3.
2006: Marei Dose; Irum Khan; Zhuyan Guo; Damian Kovalovsky; Andreas Krueger; Harald von Boehmer; Khashayarsha Khazaie; Fotini Gounari
c-Myc mediates pre-TCR-induced proliferation but not developmental progression.
Blood 2006;108(8):2669-77.
2006: Andreas Krueger; Annette I Garbe; Harald von Boehmer
Phenotypic plasticity of T cell progenitors upon exposure to Notch ligands.
The Journal of experimental medicine 2006;203(8):1977-84.
2006: Karsten Kretschmer; Irina Apostolou; Elmar Jaeckel; Khashayarsha Khazaie; Harald von Boehmer
Making regulatory T cells with defined antigen specificity: role in autoimmunity and cancer.
Immunological reviews 2006;212():163-9.
2006: Thorsten R Mempel; Mikaël J Pittet; Khashayarsha Khazaie; Wolfgang Weninger; Ralph Weissleder; Harald von Boehmer; Ulrich H von Andrian
Regulatory T cells reversibly suppress cytotoxic T cell function independent of effector differentiation.
Immunity 2006;25(1):129-41.
2006: Maria Ciofani; Gisèle C Knowles; David L. Wiest; Harald von Boehmer; Juan Carlos Zúñiga-Pflücker
Stage-specific and differential notch dependency at the alphabeta and gammadelta T lineage bifurcation.
Immunity 2006;25(1):105-16.
2006: Antonio F Campese; Annette I Garbe; Fangrong Zhang; Fabio Grassi; Isabella Screpanti; Harald von Boehmer
Notch1-dependent lymphomagenesis is assisted by but does not essentially require pre-TCR signaling.
Blood 2006;108(1):305-10.
2006: Annette I Garbe; Andreas Krueger; Fotini Gounari; Juan Carlos Zúñiga-Pflücker; Harald von Boehmer
Differential synergy of Notch and T cell receptor signaling determines alphabeta versus gammadelta lineage fate.
The Journal of experimental medicine 2006;203(6):1579-90.
2006: Ioannis Aifantis; Craig H Bassing; Annette I Garbe; Katie Sawai; Frederick W Alt; Harald von Boehmer
The E delta enhancer controls the generation of CD4- CD8- alphabetaTCR-expressing T cells that can give rise to different lineages of alphabeta T cells.
The Journal of experimental medicine 2006;203(6):1543-50.
2006: M Lucila Scimone; Ioannis Aifantis; Irina Apostolou; Harald von Boehmer; Ulrich H von Andrian
A multistep adhesion cascade for lymphoid progenitor cell homing to the thymus.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(18):7006-11.
2006: Clemens Grabher; Harald von Boehmer; A Thomas Look
Notch 1 activation in the molecular pathogenesis of T-cell acute lymphoblastic leukaemia.
Nature reviews. Cancer 2006;6(5):347-59.
2006: Harald von Boehmer
Immunology. Thoracic thymus, exclusive no longer.
Science (New York, N.Y.) 2006;312(5771):206-7.
2006: Elmar Jaeckel; Karsten Kretschmer; Irina Apostolou; Harald von Boehmer
Instruction of Treg commitment in peripheral T cells is suited to reverse autoimmunity.
Seminars in immunology 2006;18(2):89-92.
2006: Khashayarsha Khazaie; Harald von Boehmer
The impact of CD4+CD25+ Treg on tumor specific CD8+ T cell cytotoxicity and cancer.
Seminars in cancer biology 2006;16(2):124-36.
2006: Harald von Boehmer; Pawel Kisielow
Negative selection of the T-cell repertoire: where and when does it occur?
Immunological reviews 2006;209():284-9.
2006: Karsten Kretschmer; Tracy S P Heng; Harald von Boehmer
De novo production of antigen-specific suppressor cells in vivo.
Nature protocols 2006;1(2):653-61.
2006: Harald von Boehmer
Shaping the T cell repertoire.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(1):3-4.
2005: Dunja Bruder; Astrid M Westendorf; Wiebke Hansen; Silvia Prettin; Achim D Gruber; Yingjie Qian; Harald von Boehmer; Karsten Mahnke; Jan Buer
On the edge of autoimmunity: T-cell stimulation by steady-state dendritic cells prevents autoimmune diabetes.
Diabetes 2005;54(12):3395-401.
2005: Harald von Boehmer
Shaping the T cell repertoire.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(11):7067-8.
2005: Karsten Kretschmer; Irina Apostolou; Daniel Hawiger; Khashayarsha Khazaie; Michel C Nussenzweig; Harald von Boehmer
Inducing and expanding regulatory T cell populations by foreign antigen.
Nature immunology 2005;6(12):1219-27.
2005: Harald von Boehmer
Unique features of the pre-T-cell receptor alpha-chain: not just a surrogate.
Nature reviews. Immunology 2005;5(7):571-7.
2005: Harald von Boehmer
Notch in lymphopoiesis and T cell polarization.
Nature immunology 2005;6(7):641-2.
2005: Harald von Boehmer
Peptide-based instruction of suppressor commitment in naïve T cells and dynamics of immunosuppression in vivo.
Scandinavian journal of immunology 2005;62 Suppl 1():49-54.
2005: Harald von Boehmer
Mechanisms of suppression by suppressor T cells.
Nature immunology 2005;6(4):338-44.
2005: Malay Mandal; Christine Borowski; Teresa Palomero; Adolfo Ferrando; Philipp Oberdoerffer; Fanyong Meng; Antonio Ruiz-Vela; Maria Ciofani; Juan Carlos Zuniga-Pflucker; Isabella Screpanti; A Thomas Look; Stanley J Korsmeyer; Klaus Rajewsky; Harald von Boehmer; Ioannis Aifantis
The BCL2A1 gene as a pre-T cell receptor-induced regulator of thymocyte survival.
The Journal of experimental medicine 2005;201(4):603-14.
2005: Elmar Jaeckel; Harald von Boehmer; Michael P Manns
Antigen-specific FoxP3-transduced T-cells can control established type 1 diabetes.
Diabetes 2005;54(2):306-10.
2005: Mei-Ling Chen; Mikaël J Pittet; Leonid Gorelik; Richard A Flavell; Ralph Weissleder; Harald von Boehmer; Khashayarsha Khazaie
Regulatory T cells suppress tumor-specific CD8 T cell cytotoxicity through TGF-beta signals in vivo.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(2):419-24.
2004: Elmar Jaeckel; Myra A Lipes; Harald von Boehmer
Recessive tolerance to preproinsulin 2 reduces but does not abolish type 1 diabetes.
Nature immunology 2004;5(10):1028-35.
2004: Harald von Boehmer
Type 1 diabetes: focus on prevention.
Nature medicine 2004;10(8):783-4.
2004: Harald von Boehmer; Michel C Nussenzweig
The manipulation of immunity. Conference on from allergy to cancer: new perspectives for therapeutic vaccination.
EMBO reports 2004;5(8):765-70.
2004: Irina Apostolou; Harald von Boehmer
In vivo instruction of suppressor commitment in naive T cells.
The Journal of experimental medicine 2004;199(10):1401-8.
2004: Christine Borowski; Xiaoyan Li; Ioannis Aifantis; Fotini Gounari; Harald von Boehmer
Pre-TCRalpha and TCRalpha are not interchangeable partners of TCRbeta during T lymphocyte development.
The Journal of experimental medicine 2004;199(5):607-15.
2004: Dunja Bruder; Michael Probst-Kepper; Astrid M Westendorf; Robert Geffers; Stefan Beissert; Karin Loser; Harald von Boehmer; Jan Buer; Wiebke Hansen
Neuropilin-1: a surface marker of regulatory T cells.
European journal of immunology 2004;34(3):623-30.
2004: Irina Apostolou; Harald von Boehmer
The TCR-HA, INS-HA transgenic model of autoimmune diabetes: limitations and expectations.
Journal of autoimmunity 2004;22(2):111-4.
2004: Harald von Boehmer
Selection of the T-cell repertoire: receptor-controlled checkpoints in T-cell development.
Advances in immunology 2004;84():201-38.
2003: Ewa Sicinska; Ioannis Aifantis; Laurent Le Cam; Wojciech Swat; Christine Borowski; Qunyan Yu; Adolfo Ferrando; Steven D Levin; Yan Geng; Harald von Boehmer; Piotr Sicinski
Requirement for cyclin D3 in lymphocyte development and T cell leukemias.
Cancer cell 2003;4(6):451-61.
2003: Claudio Talora; Antonio F Campese; Diana Bellavia; Monica Pascucci; Saula Checquolo; Manuela Groppioni; Luigi Frati; Harald von Boehmer; Alberto Gulino; Isabella Screpanti
Pre-TCR-triggered ERK signalling-dependent downregulation of E2A activity in Notch3-induced T-cell lymphoma.
EMBO reports 2003;4(11):1067-72.
2003: Irina Apostolou; Zhenyue Hao; Klaus Rajewsky; Harald von Boehmer
Effective destruction of Fas-deficient insulin-producing beta cells in type 1 diabetes.
The Journal of experimental medicine 2003;198(7):1103-6.
2003: Harald von Boehmer
Dynamics of suppressor T cells: in vivo veritas.
The Journal of experimental medicine 2003;198(6):845-9.
2003: Colin H Martin; Ioannis Aifantis; M Lucila Scimone; Ulrich H von Andrian; Boris Reizis; Harald von Boehmer; Fotini Gounari
Efficient thymic immigration of B220+ lymphoid-restricted bone marrow cells with T precursor potential.
Nature immunology 2003;4(9):866-73.
2003: U Walter; Tanja Toepfer; Kurt E J Dittmar; Karsten Kretschmer; Jörg Lauber; Siegfried Weiss; G Servos; Oskar Lechner; Werner A Scherbaum; Stefan R Bornstein; Harald von Boehmer; Jan Buer
Pancreatic NOD beta cells express MHC class II protein and the frequency of I-A(g7) mRNA-expressing beta cells strongly increases during progression to autoimmune diabetes.
Diabetologia 2003;46(8):1106-14.
2003: Ludger Klein; Khashayarsha Khazaie; Harald von Boehmer
In vivo dynamics of antigen-specific regulatory T cells not predicted from behavior in vitro.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(15):8886-91.
2003: Loralee Haughn; Robert G Hawley; Deborah K Morrison; Harald von Boehmer; David M Hockenbery
BCL-2 and BCL-XL restrict lineage choice during hematopoietic differentiation.
The Journal of biological chemistry 2003;278(27):25158-65.
2003: Elmar Jaeckel; Ludger Klein; Natalia Martin-Orozco; Harald von Boehmer
Normal incidence of diabetes in NOD mice tolerant to glutamic acid decarboxylase.
The Journal of experimental medicine 2003;197(12):1635-44.
2003: Ludger Klein; Lydie Trautman; Stelios Psarras; Silke Schnell; Anja Siermann; Roland S Liblau; Harald von Boehmer; Khashayarsha Khazaie
Visualizing the course of antigen-specific CD8 and CD4 T cell responses to a growing tumor.
European journal of immunology 2003;33(3):806-14.
2003: Harald von Boehmer; Ioannis Aifantis; Fotini Gounari; Orly Azogui; Loralee Haughn; Irina Apostolou; Elmar Jaeckel; Fabio Grassi; Ludger Klein
Thymic selection revisited: how essential is it?
Immunological reviews 2003;191():62-78.
2002: Mark S Anderson; Emily Venanzi; Ludger Klein; Zhibin Chen; Stuart P Berzins; Shannon Turley; Harald von Boehmer; Roderick Bronson; Andrée Dierich; Christophe Benoist; Diane Mathis
Projection of an immunological self shadow within the thymus by the aire protein.
Science (New York, N.Y.) 2002;298(5597):1395-401.
2002: Yuriko Ito; Satoko Arai; Nicolai S C van Oers; Ioannis Aifantis; Harald von Boehmer; Toru Miyazaki
Positive selection by the pre-TCR yields mature CD8+ T cells.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(9):4913-9.
2002: Irina Apostolou; Adelaida Sarukhan; Ludger Klein; Harald von Boehmer
Origin of regulatory T cells with known specificity for antigen.
Nature immunology 2002;3(8):756-63.
2002: Maddalena Panigada; Simona Porcellini; Eliane Barbier; Sonja Hoeflinger; Pierre-André Cazenave; Hua Gu; Hamid Band; Harald von Boehmer; Fabio Grassi
Constitutive endocytosis and degradation of the pre-T cell receptor.
The Journal of experimental medicine 2002;195(12):1585-97.
2002: Fotini Gounari; Sabina Signoretti; Roderick Bronson; Ludger Klein; William R Sellers; Jennifer Kum; Anja Siermann; Makoto M Taketo; Harald von Boehmer; Khashayarsha Khazaie
Stabilization of beta-catenin induces lesions reminiscent of prostatic intraepithelial neoplasia, but terminal squamous transdifferentiation of other secretory epithelia.
Oncogene 2002;21(26):4099-107.
2002: Ioannis Aifantis; Christine Borowski; Fotini Gounari; H Daniel Lacorazza; Janko Nikolich-Zugich; Harald von Boehmer
A critical role for the cytoplasmic tail of pTalpha in T lymphocyte development.
Nature immunology 2002;3(5):483-8.
2002: Fotini Gounari; Ioannis Aifantis; Colin Martin; Hans Jörg Fehling; Sonja Hoeflinger; Philip Leder; Harald von Boehmer; Boris Reizis
Tracing lymphopoiesis with the aid of a pTalpha-controlled reporter gene.
Nature immunology 2002;3(5):489-96.
2002: Christine Borowski; Colin Martin; Fotini Gounari; Loralee Haughn; Ioannis Aifantis; Fabio Grassi; Harald von Boehmer
On the brink of becoming a T cell.
Current opinion in immunology 2002;14(2):200-6.
2002: Sofia Casares; Alicia Hurtado; Robert C McEvoy; Adelaida Sarukhan; Harald von Boehmer; Teodor-D Brumeanu
Down-regulation of diabetogenic CD4+ T cells by a soluble dimeric peptide-MHC class II chimera.
Nature immunology 2002;3(4):383-91.
2002: Diana Bellavia; Antonio F Campese; Saula Checquolo; Anna Balestri; Andrea Biondi; Giovanni Cazzaniga; Urban Lendahl; Hans J Fehling; Adrian C Hayday; Luigi Frati; Harald von Boehmer; Alberto Gulino; Isabella Screpanti
Combined expression of pTalpha and Notch3 in T cell leukemia identifies the requirement of preTCR for leukemogenesis.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(6):3788-93.
2002: Florence Lambolez; Orly Azogui; Anne-Marie Joret; Corinne Cordier; Harald von Boehmer; James P Di Santo; Sophie Ezine; Benedita Rocha
Characterization of T cell differentiation in the murine gut.
The Journal of experimental medicine 2002;195(4):437-49.
2002: Keiko Miyoshi; Jonathan Shillingford; Fabienne Le Provost; Fotini Gounari; Roderick Bronson; Harald von Boehmer; Makoto M Taketo; Robert Cardiff; Lothar Hennighausen; Khashayarsha Khazaie
Activation of beta -catenin signaling in differentiated mammary secretory cells induces transdifferentiation into epidermis and squamous metaplasias.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(1):219-24.
2001: Harald von Boehmer
Coming to grips with Notch.
The Journal of experimental medicine 2001;194(7):F43-6.
2001: D Gibbons; N C Douglas; Domingo F Barber; Q Liu; R Sullo; L Geng; H J Fehling; Harald von Boehmer; Adrian C Hayday
The biological activity of natural and mutant pTalpha alleles.
The Journal of experimental medicine 2001;194(5):695-703.
2001: Fotini Gounari; Ioannis Aifantis; Khashayarsha Khazaie; Sonja Hoeflinger; N Harada; Makoto M Taketo; Harald von Boehmer
Somatic activation of beta-catenin bypasses pre-TCR signaling and TCR selection in thymocyte development.
Nature immunology 2001;2(9):863-9.
2001: Karin Jooss; Bernard Gjata; Olivier Danos; Harald von Boehmer; Adelaida Sarukhan
Regulatory function of in vivo anergized CD4(+) T cells.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(15):8738-43.
2001: Ioannis Aifantis; Fotini Gounari; LUCA SCORRANO; Christine Borowski; Harald von Boehmer
Constitutive pre-TCR signaling promotes differentiation through Ca2+ mobilization and activation of NF-kappaB and NFAT.
Nature immunology 2001;2(5):403-9.
2001: Oskar Lechner; Jörg Lauber; Anke Franzke; Adelaida Sarukhan; Harald von Boehmer; Jan Buer
Fingerprints of anergic T cells.
Current biology : CB 2001;11(8):587-95.
2001: J Kirberg; Harald von Boehmer; T Brocker; Hans-Reimer Rodewald; S Takeda
Class II essential for CD4 survival.
Nature immunology 2001;2(2):136-7.
2001: Harald von Boehmer; Elmar Jaeckel
Peripheral tolerance and organ specific autoimmunity.
Advances in experimental medicine and biology 2001;490():41-8.
2001: Adelaida Sarukhan; S Camugli; Bernard Gjata; Harald von Boehmer; Olivier Danos; Karin Jooss
Successful interference with cellular immune responses to immunogenic proteins encoded by recombinant viral vectors.
Journal of virology 2001;75(1):269-77.
2000: Harald von Boehmer
T-cell lineage fate: instructed by receptor signals?
Current biology : CB 2000;10(17):R642-5.
2000: C Saint-Ruf; Maddalena Panigada; Orly Azogui; P Debey; Harald von Boehmer; Fabio Grassi
Different initiation of pre-TCR and gammadeltaTCR signalling.
Nature 2000;406(6795):524-7.
2000: U Walter; Anke Franzke; Adelaida Sarukhan; C Zober; Harald von Boehmer; Jan Buer; Oskar Lechner; A Frantzke
Monitoring gene expression of TNFR family members by beta-cells during development of autoimmune diabetes.
European journal of immunology 2000;30(4):1224-32.
2000: Martha S Jordan; MP Riley; Harald von Boehmer; Andrew J Caton
Anergy and suppression regulate CD4(+) T cell responses to a self peptide.
European journal of immunology 2000;30(1):136-44.
1999: Ioannis Aifantis; Vadim Pivniouk; F Gärtner; J Feinberg; Wojciech Swat; Frederick W Alt; Harald von Boehmer; Raif S Geha
Allelic exclusion of the T cell receptor beta locus requires the SH2 domain-containing leukocyte protein (SLP)-76 adaptor protein.
The Journal of experimental medicine 1999;190(8):1093-102.
1999: Adelaida Sarukhan; Oskar Lechner; Harald von Boehmer
Autoimmune insulitis and diabetes in the absence of antigen-specific contact between T cells and islet beta-cells.
European journal of immunology 1999;29(10):3410-6.
1999: Ioannis Aifantis; J Feinberg; Hans Jörg Fehling; James P Di Santo; Harald von Boehmer
Early T cell receptor beta gene expression is regulated by the pre-T cell receptor-CD3 complex.
The Journal of experimental medicine 1999;190(1):141-4.
1999: G Eberl; H J Fehling; Harald von Boehmer; H Robson MacDonald
Absolute requirement for the pre-T cell receptor alpha chain during NK1.1+ TCRalphabeta cell development.
European journal of immunology 1999;29(6):1966-71.
1999: Harald von Boehmer; A Sarukhan
GAD, a single autoantigen for diabetes.
Science (New York, N.Y.) 1999;284(5417):1135, 1137.
1999: Harald von Boehmer; Ioannis Aifantis; J Feinberg; Oskar Lechner; C Saint-Ruf; U Walter; Jan Buer; Orly Azogui
Pleiotropic changes controlled by the pre-T-cell receptor.
Current opinion in immunology 1999;11(2):135-42.
1999: Harald von Boehmer
T-cell development: What does Notch do for T cells?
Current biology : CB 1999;9(5):R186-8.
1999: Fabio Grassi; Eliane Barbier; Simona Porcellini; Harald von Boehmer; Pierre-André Cazenave
Surface expression and functional competence of CD3-independent TCR zeta-chains in immature thymocytes.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(5):2589-96.
1999: James P Di Santo; Ioannis Aifantis; Eleftheria E Rosmaraki; Corinne Cordier; J Feinberg; Hans Jörg Fehling; Alain Fischer; Harald von Boehmer; Benedita Rocha
The common cytokine receptor gamma chain and the pre-T cell receptor provide independent but critically overlapping signals in early alpha/beta T cell development.
The Journal of experimental medicine 1999;189(3):563-74.
1999: Harald von Boehmer; Ioannis Aifantis; Orly Azogui; C Saint-Ruf; Fabio Grassi
The impact of pre-T-cell receptor signals on gene expression in developing T cells.
Cold Spring Harbor symposia on quantitative biology 1999;64():283-9.
1998: Ioannis Aifantis; Orly Azogui; J Feinberg; C Saint-Ruf; Jan Buer; Harald von Boehmer
On the role of the pre-T cell receptor in alphabeta versus gammadelta T lineage commitment.
Immunity 1998;9(5):649-55.
1998: C Saint-Ruf; Oskar Lechner; J Feinberg; Harald von Boehmer
Genomic structure of the human pre-T cell receptor alpha chain and expression of two mRNA isoforms.
European journal of immunology 1998;28(11):3824-31.
1998: Harald von Boehmer; Ioannis Aifantis; Orly Azogui; J Feinberg; C Saint-Ruf; C Zober; Corinne Cordier; Jan Buer
Crucial function of the pre-T-cell receptor (TCR) in TCR beta selection, TCR beta allelic exclusion and alpha beta versus gamma delta lineage commitment.
Immunological reviews 1998;165():111-9.
1998: Adelaida Sarukhan; Corinne Cordier; A Lanoue; Harald von Boehmer
Allelic inclusion of T cell receptor alpha genes poses an autoimmune hazard due to low-level expression of autospecific receptors.
Immunity 1998;8(5):563-70.
1998: Adrian Bot; Sofia Casares; Simona Bot; Harald von Boehmer; Constantin A Bona
Cellular mechanisms involved in protection against influenza virus infection in transgenic mice expressing a TCR receptor specific for class II hemagglutinin peptide in CD4+ and CD8+ T cells.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(9):4500-7.
1998: Jan Buer; A Lanoue; Anke Franzke; Corinne Cordier; Harald von Boehmer; Adelaida Sarukhan
Interleukin 10 secretion and impaired effector function of major histocompatibility complex class II-restricted T cells anergized in vivo.
The Journal of experimental medicine 1998;187(2):177-83.
1998: Adelaida Sarukhan; A Lanoue; Anke Franzke; N Brousse; Jan Buer; Harald von Boehmer
Changes in function of antigen-specific lymphocytes correlating with progression towards diabetes in a transgenic model.
The EMBO journal 1998;17(1):71-80.
1997: Ioannis Aifantis; Jan Buer; Harald von Boehmer; Orly Azogui
Essential role of the pre-T cell receptor in allelic exclusion of the T cell receptor beta locus.
Immunity 1997;7(5):601-7.
1997: J Kirberg; Anton Berns; Harald von Boehmer
Peripheral T cell survival requires continual ligation of the T cell receptor to major histocompatibility complex-encoded molecules.
The Journal of experimental medicine 1997;186(8):1269-75.
1997: A Krotkova; Harald von Boehmer; Hans Jörg Fehling
Allelic exclusion in pTalpha-deficient mice: no evidence for cell surface expression of two T cell receptor (TCR)-beta chains, but less efficient inhibition of endogeneous Vbeta--> (D)Jbeta rearrangements in the presence of a functional TCR-beta transgene.
The Journal of experimental medicine 1997;186(5):767-75.
1997: Harald von Boehmer
Lymphotoxins: from cytotoxicity to lymphoid organogenesis.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(17):8926-7.
1997: Jan Buer; Ioannis Aifantis; J P DiSanto; Hans Jörg Fehling; Harald von Boehmer
T-cell development in the absence of the pre-T-cell receptor.
Immunology letters 1997;57(1-3):5-8.
1997: Hans Jörg Fehling; Brian M Iritani; A Krotkova; Katherine Forbush; C Laplace; Roger M Perlmutter; Harald von Boehmer
Restoration of thymopoiesis in pT alpha-/- mice by anti-CD3epsilon antibody treatment or with transgenes encoding activated Lck or tailless pT alpha.
Immunity 1997;6(6):703-14.
1997: Harald von Boehmer
Aspects of lymphocyte developmental biology.
Immunology today 1997;18(6):260-2.
1997: Jan Buer; Ioannis Aifantis; J P DiSanto; Hans Jörg Fehling; Harald von Boehmer
Role of different T cell receptors in the development of pre-T cells.
The Journal of experimental medicine 1997;185(9):1541-7.
1997: Harald von Boehmer
T-call development: is notch a key player in lineage decisions?
Current biology : CB 1997;7(5):R308-10.
1997: Harald von Boehmer; K Rajewsky
Lymphocyte development essential features.
Current opinion in immunology 1997;9(2):213-5.
1997: H J Fehling; Harald von Boehmer
Early alpha beta T cell development in the thymus of normal and genetically altered mice.
Current opinion in immunology 1997;9(2):263-75.
1997: A Lanoue; C Bona; Harald von Boehmer; Adelaida Sarukhan
Conditions that induce tolerance in mature CD4+ T cells.
The Journal of experimental medicine 1997;185(3):405-14.
1997: Harald von Boehmer; H J Fehling
Structure and function of the pre-T cell receptor.
Annual review of immunology 1997;15():433-52.
1996: L Bruno; Harald von Boehmer; J Kirberg
Cell division in the compartment of naive and memory T lymphocytes.
European journal of immunology 1996;26(12):3179-84.
1996: C Collins; Suzanne Norris; Gerry McEntee; Oscar Traynor; L Bruno; Harald von Boehmer; John E Hegarty; Cliona O'Farrelly
RAG1, RAG2 and pre-T cell receptor alpha chain expression by adult human hepatic T cells: evidence for extrathymic T cell maturation.
European journal of immunology 1996;26(12):3114-8.
1996: V Kronin; Ken Winkel; G Süss; A Kelso; William R Heath; J Kirberg; Harald von Boehmer; Ken Shortman
A subclass of dendritic cells regulates the response of naive CD8 T cells by limiting their IL-2 production.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(9):3819-27.
1996: L Bruno; Hans Jörg Fehling; Harald von Boehmer
The alpha beta T cell receptor can replace the gamma delta receptor in the development of gamma delta lineage cells.
Immunity 1996;5(4):343-52.
1996: Heinz Jacobs; Ferry Ossendorp; Evert de Vries; K Ungewiss; Harald von Boehmer; Jannie Borst; Anton Berns
Oncogenic potential of a pre-T cell receptor lacking the TCR beta variable domain.
Oncogene 1996;12(10):2089-99.
1996: Harald von Boehmer
CD4/CD8 lineage commitment: back to instruction?
The Journal of experimental medicine 1996;183(3):713-5.
1995: P Del Porto; L Bruno; M G Mattei; Harald von Boehmer; C Saint-Ruf
Cloning and comparative analysis of the human pre-T-cell receptor alpha-chain gene.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(26):12105-9.
1995: Harald von Boehmer
Control of T-cell development by the pre-T and alpha beta T-cell receptor.
Annals of the New York Academy of Sciences 1995;766():52-61.
1995: Harald von Boehmer
T cell differentiation: control by the pre-TCR and alpha beta TCR.
Clinical immunology and immunopathology 1995;76(3 Pt 2):S145-50.
1995: Harald von Boehmer
Immunogenetics. Female anti-male attack.
Nature 1995;376(6542):642.
1995: L Bruno; B Rocha; Antonius G Rolink; Harald von Boehmer; Hans-Reimer Rodewald
Intra- and extra-thymic expression of the pre-T cell receptor alpha gene.
European journal of immunology 1995;25(7):1877-82.
1995: Hans Jörg Fehling; A Krotkova; C Saint-Ruf; Harald von Boehmer
Crucial role of the pre-T-cell receptor alpha gene in development of alpha beta but not gamma delta T cells.
Nature 1995;375(6534):795-8.
1995: Pawel Kisielow; Harald von Boehmer
Development and selection of T cells: facts and puzzles.
Advances in immunology 1995;58():87-209.
1995: Hans Jörg Fehling; C Laplace; M G Mattei; C Saint-Ruf; Harald von Boehmer
Genomic structure and chromosomal location of the mouse pre-T-cell receptor alpha gene.
Immunogenetics 1995;42(4):275-81.
1995: L Bruno; J Kirberg; Harald von Boehmer
On the cellular basis of immunological T cell memory.
Immunity 1995;2(1):37-43.
1994: S Degermann; C Reilly; B Scott; L Ogata; Harald von Boehmer; David Lo
On the various manifestations of spontaneous autoimmune diabetes in rodent models.
European journal of immunology 1994;24(12):3155-60.
1994: C Saint-Ruf; K Ungewiss; M Groettrup; L Bruno; Hans Jörg Fehling; Harald von Boehmer
Analysis and expression of a cloned pre-T cell receptor gene.
Science (New York, N.Y.) 1994;266(5188):1208-12.
1994: Hans Jörg Fehling; W Swat; C Laplace; R Kühn; Klaus Rajewsky; U Müller; Harald von Boehmer
MHC class I expression in mice lacking the proteasome subunit LMP-7.
Science (New York, N.Y.) 1994;265(5176):1234-7.
1994: A Baron; K Hafen; Harald von Boehmer
A human CD4 transgene rescues CD4-CD8+ cells in beta 2-microglobulin-deficient mice.
European journal of immunology 1994;24(8):1933-6.
1994: J Kirberg; A Baron; S Jakob; Antonius G Rolink; K Karjalainen; Harald von Boehmer
Thymic selection of CD8+ single positive cells with a class II major histocompatibility complex-restricted receptor.
The Journal of experimental medicine 1994;180(1):25-34.
1994: W Swat; Harald von Boehmer; Pawel Kisielow
Small CD4+8+TCRlow thymocytes contain precursors of mature T cells.
European journal of immunology 1994;24(4):1010-2.
1994: W Swat; Harald von Boehmer; Pawel Kisielow
Central tolerance: clonal deletion or clonal arrest?
European journal of immunology 1994;24(2):485-7.
1994: Harald von Boehmer
Positive selection of lymphocytes.
Cell 1994;76(2):219-28.
1993: M Groettrup; Harald von Boehmer
A role for a pre-T-cell receptor in T-cell development.
Immunology today 1993;14(12):610-4.
1993: M Groettrup; K Ungewiss; Orly Azogui; R Palacios; M J Owen; A C Hayday; Harald von Boehmer
A novel disulfide-linked heterodimer on pre-T cells consists of the T cell receptor beta chain and a 33 kd glycoprotein.
Cell 1993;75(2):283-94.
1993: Harald von Boehmer; W Swat; Pawel Kisielow
Positive selection of immature alpha beta T cells.
Immunological reviews 1993;135():67-79.
1993: J Kirberg; L Bruno; Harald von Boehmer
CD4+8- help prevents rapid deletion of CD8+ cells after a transient response to antigen.
European journal of immunology 1993;23(8):1963-7.
1993: K A Kelly; H Pircher; Harald von Boehmer; M M Davis; Roland Scollay
Regulation of T cell production in T cell receptor transgenic mice.
European journal of immunology 1993;23(8):1922-8.
1993: M Groettrup; Harald von Boehmer
T cell receptor beta chain dimers on immature thymocytes from normal mice.
European journal of immunology 1993;23(6):1393-6.
1993: Benedita Rocha; Corinne Tanchot; Harald von Boehmer
Clonal anergy blocks in vivo growth of mature T cells and can be reversed in the absence of antigen.
The Journal of experimental medicine 1993;177(5):1517-21.
1993: Harald von Boehmer; Pawel Kisielow
Lymphocyte lineage commitment: instruction versus selection.
Cell 1993;73(2):207-8.
1993: Harald von Boehmer
Immunology. Tolerance by exhaustion.
Nature 1993;362(6422):696.
1993: Harald von Boehmer; K Hafen
The life span of naive alpha/beta T cells in secondary lymphoid organs.
The Journal of experimental medicine 1993;177(4):891-6.
1993: W Swat; M Dessing; Harald von Boehmer; Pawel Kisielow
CD69 expression during selection and maturation of CD4+8+ thymocytes.
European journal of immunology 1993;23(3):739-46.
1993: Pawel Kisielow; Harald von Boehmer
Role of the thymus in the acquisition of immunologic self-tolerance.
Experimental nephrology 1993;1(2):112-9.
1993: J Kirberg; W Swat; B Rocha; Pawel Kisielow; Harald von Boehmer
Induction of tolerance in immature and mature T cells.
Transplantation proceedings 1993;25(1 Pt 1):279-80.
1992: Harald von Boehmer
Thymic selection: a matter of life and death.
Immunology today 1992;13(11):454-8.
1992: W Swat; M Dessing; A Baron; Pawel Kisielow; Harald von Boehmer
Phenotypic changes accompanying positive selection of CD4+CD8+ thymocytes.
European journal of immunology 1992;22(9):2367-72.
1992: M Groettrup; A Baron; G Griffiths; R Palacios; Harald von Boehmer
T cell receptor (TCR) beta chain homodimers on the surface of immature but not mature alpha, gamma, delta chain deficient T cell lines.
The EMBO journal 1992;11(7):2735-45.
1992: B Rocha; Harald von Boehmer; D Guy-Grand
Selection of intraepithelial lymphocytes with CD8 alpha/alpha co-receptors by self-antigen in the murine gut.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(12):5336-40.
1992: P Borgulya; H Kishi; Y Uematsu; Harald von Boehmer
Exclusion and inclusion of alpha and beta T cell receptor alleles.
Cell 1992;69(3):529-37.
1992: CL Sidman; J D Marshall; Harald von Boehmer
Transgenic T cell receptor interactions in the lymphoproliferative and autoimmune syndromes of lpr and gld mutant mice.
European journal of immunology 1992;22(2):499-504.
1992: Harald von Boehmer
T cell development and selection in the thymus.
Bone marrow transplantation 1992;9 Suppl 1():46-8.
1991: Harald von Boehmer; J Kirberg; B Rocha
An unusual lineage of alpha/beta T cells that contains autoreactive cells.
The Journal of experimental medicine 1991;174(5):1001-8.
1991: Harald von Boehmer; P Kisielow
How the immune system learns about self.
Scientific American 1991;265(4):74-81.
1991: M Huesmann; B Scott; Pawel Kisielow; Harald von Boehmer
Kinetics and efficacy of positive selection in the thymus of normal and T cell receptor transgenic mice.
Cell 1991;66(3):533-40.
1991: Pawel Kisielow; W Swat; B Rocha; Harald von Boehmer
Induction of immunological unresponsiveness in vivo and in vitro by conventional and super-antigens in developing and mature T cells.
Immunological reviews 1991;122():69-85.
1991: W Swat; Leszek Ignatowicz; Harald von Boehmer; Pawel Kisielow
Clonal deletion of immature CD4+8+ thymocytes in suspension culture by extrathymic antigen-presenting cells.
Nature 1991;351(6322):150-3.
1991: P Borgulya; H Kishi; U Müller; J Kirberg; Harald von Boehmer
Development of the CD4 and CD8 lineage of T cells: instruction versus selection.
The EMBO journal 1991;10(4):913-8.
1991: Harald von Boehmer
Positive and negative selection of the alpha beta T-cell repertoire in vivo.
Current opinion in immunology 1991;3(2):210-5.
1991: B Rocha; Harald von Boehmer
Peripheral selection of the T cell repertoire.
Science (New York, N.Y.) 1991;251(4998):1225-8.
1991: Pawel Kisielow; Harald von Boehmer
Kinetics of negative and positive selection in the thymus.
Advances in experimental medicine and biology 1991;292():31-42.
1991: H Kishi; P Borgulya; B Scott; K Karjalainen; A Traunecker; J Kaufman; Harald von Boehmer
Surface expression of the beta T cell receptor (TCR) chain in the absence of other TCR or CD3 proteins on immature T cells.
The EMBO journal 1991;10(1):93-100.
1990: Harald von Boehmer
Self recognition by the immune system.
European journal of biochemistry / FEBS 1990;194(3):693-8.
1990: H Jacobs; Harald von Boehmer; C J Melief; A Berns
Mutations in the major histocompatibility complex class I antigen-presenting groove affect both negative and positive selection of T cells.
European journal of immunology 1990;20(10):2333-7.
1990: Harald von Boehmer; Pawel Kisielow
Self-nonself discrimination by T cells.
Science (New York, N.Y.) 1990;248(4961):1369-73.
1990: Harald von Boehmer
Developmental biology of T cells in T cell-receptor transgenic mice.
Annual review of immunology 1990;8():531-56.
1990: Hung-Sia Teh; H Kishi; B Scott; P Borgulya; Harald von Boehmer; Pawel Kisielow
Early deletion and late positive selection of T cells expressing a male-specific receptor in T-cell receptor transgenic mice.
Developmental immunology 1990;1(1):1-10.
1990: Pawel Kisielow; Harald von Boehmer
Negative and positive selection of immature thymocytes: timing and the role of the ligand for alpha beta T cell receptor.
Seminars in immunology 1990;2(1):35-44.
1990: Willem van Ewijk; P Kisielow; Harald von Boehmer
Immunohistology of T cell differentiation in the thymus of H-Y-specific T cell receptor alpha/beta transgenic mice.
European journal of immunology 1990;20(1):129-37.
1989: Harald von Boehmer; Pawel Kisielow; H Kishi; B Scott; P Borgulya; Hung-Sia Teh
The expression of CD4 and CD8 accessory molecules on mature T cells is not random but correlates with the specificity of the alpha beta receptor for antigen.
Immunological reviews 1989;109():143-51.
1989: B Scott; H Blüthmann; Hung-Sia Teh; Harald von Boehmer
The generation of mature T cells requires interaction of the alpha beta T-cell receptor with major histocompatibility antigens.
Nature 1989;338(6216):591-3.
1989: Hung-Sia Teh; H Kishi; B Scott; Harald von Boehmer
Deletion of autospecific T cells in T cell receptor (TCR) transgenic mice spares cells with normal TCR levels and low levels of CD8 molecules.
The Journal of experimental medicine 1989;169(3):795-806.
1989: Harald von Boehmer; H S Teh; P Kisielow
The thymus selects the useful, neglects the useless and destroys the harmful.
Immunology today 1989;10(2):57-61.
1989: Harald von Boehmer; H Blüthmann; Hung-Sia Teh; B Scott
The utilization of the scid mutation in the study of T cell development.
Current topics in microbiology and immunology 1989;152():97-105.
1989: Harald von Boehmer; H Kishi; P Borgulya; B Scott; W van Ewijk; Hung-Sia Teh; Pawel Kisielow
Control of T-cell development by the TCR alpha beta for antigen.
Cold Spring Harbor symposia on quantitative biology 1989;54 Pt 1():111-8.
1989: Harald von Boehmer
Learning by the immune system studied in T-cell receptor transgenic mice.
Thymus 1989;13(1-2):19-26.
1988: Harald von Boehmer; M Bonneville; I Ishida; S Ryser; G Lincoln; R T Smith; H Kishi; B Scott; P Kisielow; Susumu Tonegawa
Early expression of a T-cell receptor beta-chain transgene suppresses rearrangement of the V gamma 4 gene segment.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(24):9729-32.
1988: Pawel Kisielow; Hung-Sia Teh; H Blüthmann; Harald von Boehmer
Positive selection of antigen-specific T cells in thymus by restricting MHC molecules.
Nature 1988;335(6192):730-3.
1988: Hung-Sia Teh; Pawel Kisielow; B Scott; H Kishi; Y Uematsu; H Blüthmann; Harald von Boehmer
Thymic major histocompatibility complex antigens and the alpha beta T-cell receptor determine the CD4/CD8 phenotype of T cells.
Nature 1988;335(6187):229-33.
1988: H Blüthmann; Pawel Kisielow; Y Uematsu; M Malissen; Paul Krimpenfort; Anton Berns; Harald von Boehmer; M Steinmetz
T-cell-specific deletion of T-cell receptor transgenes allows functional rearrangement of endogenous alpha- and beta-genes.
Nature 1988;334(6178):156-9.
1988: Pawel Kisielow; H Blüthmann; U D Staerz; M Steinmetz; Harald von Boehmer
Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes.
Nature 1988;333(6175):742-6.
1988: Y Uematsu; S Ryser; Z Dembić; P Borgulya; Paul Krimpenfort; Anton Berns; Harald von Boehmer; M Steinmetz
In transgenic mice the introduced functional T cell receptor beta gene prevents expression of endogenous beta genes.
Cell 1988;52(6):831-41.
1988: Paul Krimpenfort; R de Jong; Y Uematsu; Z Dembic; S Ryser; Harald von Boehmer; M Steinmetz; Anton Berns
Transcription of T cell receptor beta-chain genes is controlled by a downstream regulatory element.
The EMBO journal 1988;7(3):745-50.
1988: Harald von Boehmer
The developmental biology of T lymphocytes.
Annual review of immunology 1988;6():309-26.
1988: Harald von Boehmer; K Karjalainen; J Pelkonen; P Borgulya; H G Rammensee
The T-cell receptor for antigen in T-cell development and repertoire selection.
Immunological reviews 1988;101():21-37.
1988: Harald von Boehmer; H Kishi; Y Uematsu; Hung-Sia Teh; B Scott; Pawel Kisielow
T cell repertoire selection in T cell receptor transgenic mice.
Princess Takamatsu symposia 1988;19():107-13.
1988: Harald von Boehmer; H Bluethmann; U Staerz; M Steinmetz; Pawel Kisielow
Developmental biology of T lymphocytes. Deletion of autoreactive T cells and impact of the alpha, beta receptor on the CD4/CD8 phenotype.
Annals of the New York Academy of Sciences 1988;546():104-8.
1987: R Palacios; M Kiefer; M Brockhaus; K Karjalainen; Z Dembić; P Kisielow; Harald von Boehmer
Molecular, cellular, and functional properties of bone marrow T lymphocyte progenitor clones.
The Journal of experimental medicine 1987;166(1):12-32.
1987: Z Dembić; W Haas; R Zamoyska; Jane R Parnes; M Steinmetz; Harald von Boehmer
Transfection of the CD8 gene enhances T-cell recognition.
Nature 1987;326(6112):510-1.
1987: R Palacios; P Sideras; Harald von Boehmer
Recombinant interleukin 4/BSF-1 promotes growth and differentiation of intrathymic T cell precursors from fetal mice in vitro.
The EMBO journal 1987;6(1):91-5.
1986: A Cristanti; A Colantoni; R Snodgrass; Harald von Boehmer
Expression of T cell receptors by thymocytes: in situ staining and biochemical analysis.
The EMBO journal 1986;5(11):2837-43.
1986: Harald von Boehmer; K Hafen
Minor but not major histocompatibility antigens of thymus epithelium tolerize precursors of cytolytic T cells.
Nature 1986;320(6063):626-8.
1986: Z Dembić; W Haas; S Weiss; J McCubrey; H Kiefer; Harald von Boehmer; M Steinmetz
Transfer of specificity by murine alpha and beta T-cell receptor genes.
Nature 1986;320(6059):232-8.
1986: Harald von Boehmer; W Haas
Cytolytic T-cell clones and hybridomas.
Methods in enzymology 1986;132():467-77.
1986: R Palacios; Harald von Boehmer
Requirements for growth of immature thymocytes from fetal and adult mice in vitro.
European journal of immunology 1986;16(1):12-9.
1986: Harald von Boehmer
Thymus development.
Current topics in microbiology and immunology 1986;126():19-25.
1985: W Haas; J Mathur-Rochat; P Kisielow; Harald von Boehmer
Cytolytic T cell hybridomas. III. The antigen specificity and the restriction specificity of cytolytic T cells do not phenotypically mix.
European journal of immunology 1985;15(9):963-5.
1985: H R Snodgrass; Z Dembić; M Steinmetz; Harald von Boehmer
Expression of T-cell antigen receptor genes during fetal development in the thymus.
Nature 1985;315(6016):232-3.
1985: Harald von Boehmer; A Crisanti; P Kisielow; W Haas
Absence of growth by most receptor-expressing fetal thymocytes in the presence of interleukin-2.
Nature 1985;314(6011):539-40.
1985: H R Snodgrass; P Kisielow; M Kiefer; M Steinmetz; Harald von Boehmer
Ontogeny of the T-cell antigen receptor within the thymus.
Nature 1985;313(6003):592-5.
1984: W Haas; J Mathur-Rochat; H Pohlit; Harald von Boehmer
Cytotoxic T cell responses to haptenated cells. IV. Requirements for in vivo priming.
European journal of immunology 1984;14(11):1069-72.
1984: Harald von Boehmer; K Schubiger
Thymocytes appear to ignore class I major histocompatibility complex antigens expressed on thymus epithelial cells.
European journal of immunology 1984;14(11):1048-52.
1984: P Kisielow; W Leiserson; Harald von Boehmer
Differentiation of thymocytes in fetal organ culture: analysis of phenotypic changes accompanying the appearance of cytolytic and interleukin 2-producing cells.
Journal of immunology (Baltimore, Md. : 1950) 1984;133(3):1117-23.
1984: Harald von Boehmer; P Kisielow; W Leiserson; W Haas
Lyt-2- T cell-independent functions of Lyt-2+ cells stimulated with antigen or concanavalin A.
Journal of immunology (Baltimore, Md. : 1950) 1984;133(1):59-64.
1984: W Haas; Harald von Boehmer
Surface markers of cytotoxic T lymphocyte clones.
European journal of immunology 1984;14(4):383-4.
1983: Harald von Boehmer; J Bennink; H S Teh; W Haas
Selection of the T-cell repertoire during ontogeny.
Annales d'immunologie 1983;134D(1):17-24.
1983: Harald von Boehmer
Ontogenic aspects of the syngeneic mixed leukocyte reaction.
Behring Institute Mitteilungen 1983;(72):3-6.
1983: H S Teh; R Romaniuk; Harald von Boehmer
H-2D products do not affect lysis of Kk target cells by Kk-specific cytotoxic T cells.
European journal of immunology 1983;13(3):259-61.
1983: Harald von Boehmer; K Turton
Autonomously proliferating K/D-restricted cytolytic T cell clones.
European journal of immunology 1983;13(2):176-9.
1982: Harald von Boehmer; J Bennink; J Langhorne
The frequency of mutant-specific killer precursors in related and unrelated mouse strains.
European journal of immunology 1982;12(10):892-5.
1982: H S Teh; J Bennink; Harald von Boehmer
Selection of the T cell repertoire during ontogeny: limiting dilution analysis.
European journal of immunology 1982;12(10):887-92.
1982: W Haas; Harald von Boehmer
Methods for the establishment of continuously growing cytolytic T cell clones.
Journal of immunological methods 1982;52(2):137-48.
1982: P Kisielow; Harald von Boehmer; W Haas
Functional and phenotypic properties of subpopulations of murine thymocytes. I. The bulk of peanut agglutinin-positive Lyt-1,2,3 thymocytes lacks precursors of cytotoxic T lymphocytes responsive to interleukin 2 (T cell growth factor).
European journal of immunology 1982;12(6):463-7.
1982: J Günther; W Haas; Harald von Boehmer
Suppression of T cell responses through competition for T cell growth factor (interleukin 2).
European journal of immunology 1982;12(3):247-9.
1982: Harald von Boehmer
Immune response regulation.
Advances in experimental medicine and biology 1982;149():733-6.
1981: Y Kurosawa; Harald von Boehmer; W Haas; H Sakano; A Trauneker; Susumu Tonegawa
Identification of D segments of immunoglobulin heavy-chain genes and their rearrangement in T lymphocytes.
Nature 1981;290(5807):565-70.
1981: C Martinez-Alonso; A Coutinho; Harald von Boehmer; R Bernabé
Hapten-specific helper T cells III. Fine specificity of the (4-hydroxy-3-nitro-phenyl)acetyl (NP)-specific response in Igh-1b mice.
European journal of immunology 1981;11(3):172-4.
1981: Harald von Boehmer; W Haas
H-2 restricted cytolytic and noncytolytic T cell clones: isolation, specificity and functional analysis.
Immunological reviews 1981;54():27-56.
1980: W Haas; J Mathur-Rochat; H Pohlit; Markus Nabholz; Harald von Boehmer
Cytotoxic T cell responses to haptenated cells. III. Isolation and specificity analysis of continuously growing clones.
European journal of immunology 1980;10(11):828-34.
1980: Markus Nabholz; M Cianfriglia; Oreste Acuto; A Conzelmann; W Haas; Harald von Boehmer; H R McDonald; H Pohlit; J P Johnson
Cytolytically active murine T-cell hybrids.
Nature 1980;287(5781):437-40.
1980: H D Engers; D Collavo; M North; Harald von Boehmer; W Haas; H Hengartner; Markus Nabholz
Characterization of cloned murine cytolytic T cell lines.
Journal of immunology (Baltimore, Md. : 1950) 1980;125(4):1481-6.
1980: Harald von Boehmer; W Haas; H Pohlit; H Hengartner; Markus Nabholz
T cell clones: their use for the study of specificity, induction, and effector-function of T cells.
Springer seminars in immunopathology 1980;3(1):23-37.
1980: MH Schreier; N N Iscove; R Tees; L Aarden; Harald von Boehmer
Clones of killer and helper T cells: growth requirements, specificity and retention of function in long-term culture.
Immunological reviews 1980;51():315-36.
1980: Markus Nabholz; A Conzelmann; Oreste Acuto; M North; W Haas; H Pohlit; Harald von Boehmer; H Hengartner; J P Mach; H Engers; J P Johnson
Established murine cytolytic T-cell lines as tools for a somatic cell genetic analysis of T-cell functions.
Immunological reviews 1980;51():125-56.
1979: Harald von Boehmer; K Turton; W Haas
The role of the left end of the H-2b haplotype in the male-specific cytotoxic T cell response.
European journal of immunology 1979;9(11):913-5.
1979: Harald von Boehmer; W Haas
Distinct Ir genes for helper and killer cells in the cytotoxic response to H-Y antigen.
The Journal of experimental medicine 1979;150(5):1134-42.
1979: H Pohlit; W Haas; Harald von Boehmer
Cytotoxic T cell responses to haptenated cells. I. Primary, secondary and long-term cultures.
European journal of immunology 1979;9(9):681-90.
1979: Harald von Boehmer; H Hengartner; M Nabholz; W Lernhardt; M H Schreier; W Haas
Fine specificity of a continuously growing killer cell clone specific for H-Y antigen.
European journal of immunology 1979;9(8):592-7.
1979: J Sprent; Harald von Boehmer
T-helper function of parent leads to F1 chimeras. Presence of a separate T-cell subgroup able to stimulate allogeneic B cells but not syngeneic B cells.
The Journal of experimental medicine 1979;149(2):387-97.
1978: P Erb; B Meier; D Kraus; Harald von Boehmer; M Feldmann
Nature of T cell-macrophage interaction in helper cell induction in vitro. I. Evidence for genetic restriction of T cell-macrophage interactions prior to T cell priming.
European journal of immunology 1978;8(11):786-92.
1978: Harald von Boehmer; W Haas; Niels K Jerne
Major histocompatibility complex-linked immune-responsiveness is acquired by lymphocytes of low-responder mice differentiating in thymus of high-responder mice.
Proceedings of the National Academy of Sciences of the United States of America 1978;75(5):2439-42.
1978: Harald von Boehmer; W Haas; H Pohlit
Cytotoxic T cells recognize male antigen and H-2 as distinct entities.
The Journal of experimental medicine 1978;147(4):1291-5.
1978: W Haas; Harald von Boehmer
Techniques for separation and selection of antigen specific lymphocytes.
Current topics in microbiology and immunology 1978;84():1-120.
1977: Harald von Boehmer; C G Fathman; W Haas
H-2 gene complementation in cytotoxic T cell responses of female against male cells.
European journal of immunology 1977;7(7):443-7.
1977: Harald von Boehmer; J Sprent; W Haas
The influence of H-2 gene products on cell-mediated and humoral immune responses.
Cold Spring Harbor symposia on quantitative biology 1977;41 Pt 2():539-45.
1976: J Sprent; Harald von Boehmer
Helper function of T cells depleted of alloantigen-reactive lymphocytes by filtration through irradiated F1 hybrid recipients. I. Failure to collaborate with allogeneic B cells in a secondary response to sheep erythrocytes measured in vivo.
The Journal of experimental medicine 1976;144(3):617-26.
1976: F Melchers; R E Cone; Harald von Boehmer; J Sprent
Immunoglobulin turnover in B lymphocyte subpopulations.
European journal of immunology 1976;5(6):382-8.
1976: Harald von Boehmer; W Haas
Cytotoxic T lymphocytes recognise allogeneic tolerated TNP-conjugated cells.
Nature 1976;261(5556):141-2.
1976: J Sprent; Harald von Boehmer
Activation of T lymphocytes to M locus determinants in vivo. I. Quantitation of T cell proliferation and migration into thoracic duct lymph.
European journal of immunology 1976;6(5):352-8.
1976: P H Krammer; B E Elliott; Harald von Boehmer
Fc-rosetting and nonrosetting T cells are killer cells.
European journal of immunology 1976;6(2):138-9.
1975: Harald von Boehmer; L Hudson; J Sprent
Collaboration of histoincompatible T and B lymphocytes using cells from tetraparental bone marrow chimeras.
The Journal of experimental medicine 1975;142(4):989-97.
1975: D G Osmond; R G Miller; Harald von Boehmer
Characterization of immunoglobulin-bearing and other small lymphocytes in mouse bone marrow by sedimentation and electrophoresis.
Journal of immunology (Baltimore, Md. : 1950) 1975;114(4):1230-6.
1975: G E Roelants; F Loor; Harald von Boehmer; J Sprent; L B Hägg; K S Mayor; A Rydén
Five types of lymphocytes (Ig-theta-, Ig-theta+weak, Ig-theta+strong, Ig+theta- and Ig+theta+) characterized by double immunofluorescence and electrophoretic mobility. Organ distribution in normal and nude mice.
European journal of immunology 1975;5(2):127-31.
1974: Harald von Boehmer; J Sprent
Expression of M locus differences by B cells but not T cells.
Nature 1974;249(455):363-5.
1974: Harald von Boehmer
Selective stimulation by B lymphocytes in the syngeneic mixed lymphocyte reaction.
European journal of immunology 1974;4(2):105-10.
1973: Harald von Boehmer
Direct cell contact is required in the syngeneic mixed lymphocyte reaction.
European journal of immunology 1973;3(2):109-11.
1973: Harald von Boehmer; P B Adams
Syngeneic mixed lymphocyte reaction between thymocytes and peripheral lymphoid cells in mice: strain specificity and nature of the target cell.
Journal of immunology (Baltimore, Md. : 1950) 1973;110(2):376-83.
1972: Harald von Boehmer; K Shortman; P Adams
Nature of the stimulating cell in the syngeneic and the allogeneic mixed lymphocyte reaction in mice.
The Journal of experimental medicine 1972;136(6):1648-60.