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Gunnar von Heijne

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Chemicals & Drugs

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Escherichia coli

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TOP 3
Salomé Calado Botelho; Takashi Tatsuta; Gunnar von Heijne; Hyun Kim
Dislocation by the m-AAA protease increases the threshold hydrophobicity for retention of transmembrane helices in the inner membrane of yeast mitochondria.
Karin Öjemalm; Benedict C S Cross; Peristera Roboti; Gunnar von Heijne; Jim Warwicker; Helen R Watson; Stephen High
Positional editing of transmembrane domains during ion channel assembly.
Hunsang Lee; Jisoo Min; Gunnar von Heijne; Hyun Kim
Glycosylatable GFP as a compartment-specific membrane topology reporter.

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All Publications

2013: Salomé Calado Botelho; Takashi Tatsuta; Gunnar von Heijne; Hyun Kim
Dislocation by the m-AAA protease increases the threshold hydrophobicity for retention of transmembrane helices in the inner membrane of yeast mitochondria.
The Journal of biological chemistry 2013;288(7):4792-8.
2013: Karin Öjemalm; Benedict C S Cross; Peristera Roboti; Gunnar von Heijne; Jim Warwicker; Helen R Watson; Stephen High
Positional editing of transmembrane domains during ion channel assembly.
Journal of cell science 2013;126(Pt 2):464-72.
2012: Hunsang Lee; Jisoo Min; Gunnar von Heijne; Hyun Kim
Glycosylatable GFP as a compartment-specific membrane topology reporter.
Biochemical and biophysical research communications 2012;427(4):780-4.
2012: Nurzian Ismail; Nina Schiller; Rickard Hedman; Gunnar von Heijne
A biphasic pulling force acts on transmembrane helices during translocon-mediated membrane integration.
Nature structural & molecular biology 2012;19(10):1018-22.
2012: Stephen Toddo; Gunnar von Heijne; Morten H H Nørholm; Isolde Palombo; Bill Söderström; Daniel O Daley
Application of split-green fluorescent protein for topology mapping membrane proteins in Escherichia coli.
Protein science : a publication of the Protein Society 2012;21(10):1571-6.
2012: Pilar Lloris-Garcerá; Susanna Seppälä; Joanna S G Slusky; Frans Bianchi; Daniel O Daley; Gunnar von Heijne
Antiparallel dimers of the small multidrug resistance protein EmrE are more stable than parallel dimers.
The Journal of biological chemistry 2012;287(31):26052-9.
2012: Carmen Galian; Patrik Björkholm; Neil Bulleid; Gunnar von Heijne
Efficient glycosylphosphatidylinositol (GPI) modification of membrane proteins requires a C-terminal anchoring signal of marginal hydrophobicity.
The Journal of biological chemistry 2012;287(20):16399-409.
2012: Morten H H Nørholm; Minttu T I Virkki; Gunnar von Heijne; Arne Elofsson; Sara Light; Daniel O Daley
Manipulating the genetic code for membrane protein production: what have we learnt so far?
Biochimica et biophysica acta 2012;1818(4):1091-6.
2012: Karin Ojemalm; Katrin K Halling; Ingmarie Nilsson; Gunnar von Heijne
Orientational preferences of neighboring helices can drive ER insertion of a marginally hydrophobic transmembrane helix.
Molecular cell 2012;45(4):529-40.
2012: Karl Skoog; Bill Söderström; Gunnar von Heijne; Jerker Widengren; Daniel O Daley
Sequential closure of the cytoplasm and then the periplasm during cell division in Escherichia coli.
Journal of bacteriology 2012;194(3):584-6.
2012: F-Xabier Contreras; Arne Elofsson; Andreas M Ernst; Başak Gönen; Per Haberkant; Erik Lindahl; Rainer Pepperkok; Christoph Thiele; Christian Tischer; Gunnar von Heijne; Felix Wieland; Patrik Björkholm; Britta Brügger
Molecular recognition of a single sphingolipid species by a protein's transmembrane domain.
Nature 2012;481(7382):525-9.
2011: Karin Öjemalm; Stephen H White; Ulo Langel; Takashi Higuchi; Yang Jiang; IngMarie Nilsson; Hiroaki Suga; Gunnar von Heijne
Apolar surface area determines the efficiency of translocon-mediated membrane-protein integration into the endoplasmic reticulum.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(31):E359-64.
2011: Gunnar von Heijne
Introduction to theme "membrane protein folding and insertion".
Annual review of biochemistry 2011;80():157-60.
2011: Gunnar von Heijne
Membrane proteins: from bench to bits.
Biochemical Society transactions 2011;39(3):747-50.
2011: Marie Österberg; Salomé Calado Botelho; Gunnar von Heijne; Hyun Kim
Charged flanking residues control the efficiency of membrane insertion of the first transmembrane segment in yeast mitochondrial Mgm1p.
FEBS letters 2011;585(8):1238-42.
2011: Morten H H Nørholm; Fiona Cunningham; Charles M Deber; Gunnar von Heijne
Converting a marginally hydrophobic soluble protein into a membrane protein.
Journal of molecular biology 2011;407(1):171-9.
2011: Salomé Calado Botelho; Marie Österberg; Andreas S Reichert; Koji Yamano; Patrik Björkholm; Toshiya Endo; Gunnar von Heijne; Hyun Kim
TIM23-mediated insertion of transmembrane α-helices into the mitochondrial inner membrane.
The EMBO journal 2011;30(6):1003-11.
2011: Thomas Nordahl Petersen; Gunnar von Heijne; Søren Brunak; Henrik Nielsen
SignalP 4.0: discriminating signal peptides from transmembrane regions.
Nature methods 2011;8(10):785-6.
2011: Eric V Schow; J Alfredo Freites; Philip Cheng; Andreas Bernsel; Gunnar von Heijne; Stephen H White; Douglas J Tobias
Arginine in membranes: the connection between molecular dynamics simulations and translocon-mediated insertion experiments.
The Journal of membrane biology 2011;239(1-2):35-48.
2010: Susanna Seppälä; Joanna S Slusky; Pilar Lloris-Garcerá; Mikaela Rapp; Gunnar von Heijne
Control of membrane protein topology by a single C-terminal residue.
Science (New York, N.Y.) 2010;328(5986):1698-700.
2010: Johan Strömqvist; Karl Skoog; Daniel O Daley; Jerker Widengren; Gunnar von Heijne
Estimating Z-ring radius and contraction in dividing Escherichia coli.
Molecular microbiology 2010;76(1):151-8.
2010: Anni Kauko; Linnea E Hedin; Estelle Thebaud; Susana Cristobal; Arne Elofsson; Gunnar von Heijne
Repositioning of transmembrane alpha-helices during membrane protein folding.
Journal of molecular biology 2010;397(1):190-201.
2010: Linn Fagerberg; Kalle Jonasson; Gunnar von Heijne; Mathias Uhlén; Lisa Berglund
Prediction of the human membrane proteome.
Proteomics 2010;10(6):1141-9.
2010: Linnea E Hedin; Karin Ojemalm; Andreas Bernsel; Aron Hennerdal; Kristoffer Illergård; Karl Enquist; Anni Kauko; Susana Cristobal; Gunnar von Heijne; Mirjam Lerch-Bader; IngMarie Nilsson; Arne Elofsson
Membrane insertion of marginally hydrophobic transmembrane helices depends on sequence context.
Journal of molecular biology 2010;396(1):221-9.
2010: Souhei Sakata; Tatsuki Kurokawa; Morten H H Nørholm; Masahiro Takagi; Yoshifumi Okochi; Gunnar von Heijne; Yasushi Okamura
Functionality of the voltage-gated proton channel truncated in S4.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(5):2313-8.
2010: Robert Daniels; Peter Mellroth; Andreas Bernsel; Fabrice Neiers; Staffan Normark; Gunnar von Heijne; Birgitta Henriques Normark
Disulfide bond formation and cysteine exclusion in gram-positive bacteria.
The Journal of biological chemistry 2010;285(5):3300-9.
2009: Simon Jaud; Mónica Fernández-Vidal; Ingmarie Nilsson; Nadja M Meindl-Beinker; Nadja C Hübner; Douglas J Tobias; Gunnar von Heijne; Stephen H White
Insertion of short transmembrane helices by the Sec61 translocon.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(28):11588-93.
2009: Karl Enquist; Mawritz Fransson; Carolina Boekel; Inger Bengtsson; Karin Geiger; Lisa Lang; Aron Pettersson; Sofia Johansson; Gunnar von Heijne; IngMarie Nilsson
Membrane-integration characteristics of two ABC transporters, CFTR and P-glycoprotein.
Journal of molecular biology 2009;387(5):1153-64.
2009: Tara Hessa; Johannes H Reithinger; Gunnar von Heijne; Hyun Kim
Analysis of transmembrane helix integration in the endoplasmic reticulum in S. cerevisiae.
Journal of molecular biology 2009;386(5):1222-8.
2009: Agnieszka S Juncker; Lars Jensen; Andrea Pierleoni; Andreas Bernsel; Michael L Tress; Peer Bork; Gunnar von Heijne; Alfonso Valencia; Christos Ouzounis; Rita Casadio; Søren Brunak
Sequence-based feature prediction and annotation of proteins.
Genome biology 2009;10(2):206.
2008: Carolina Boekel Lundin; Hyun Kim; IngMarie Nilsson; Stephen H White; Gunnar von Heijne
Molecular code for protein insertion in the endoplasmic reticulum membrane is similar for N(in)-C(out) and N(out)-C(in) transmembrane helices.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(41):15702-7.
2008: Marika Cassel; Susanna Seppälä; Gunnar von Heijne
Confronting fusion protein-based membrane protein topology mapping with reality: the Escherichia coli ClcA H+/Cl- exchange transporter.
Journal of molecular biology 2008;381(4):860-6.
2008: Gunnar von Heijne; Douglas Rees
Membranes: reading between the lines.
Current opinion in structural biology 2008;18(4):403-5.
2008: Andreas Bernsel; Håkan Viklund; Jenny Falk; Erik Lindahl; Gunnar von Heijne; Arne Elofsson
Prediction of membrane-protein topology from first principles.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(20):7177-81.
2008: Mirjam Lerch-Bader; Carolina Boekel Lundin; Hyun Kim; Ingmarie Nilsson; Gunnar von Heijne
Contribution of positively charged flanking residues to the insertion of transmembrane helices into the endoplasmic reticulum.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(11):4127-32.
2008: Stephen H White; Gunnar von Heijne
How translocons select transmembrane helices.
Annual review of biophysics 2008;37():23-42.
2008: David Drew; Simon Newstead; Yo Sonoda; Hyun Kim; Gunnar von Heijne; So Iwata
GFP-based optimization scheme for the overexpression and purification of eukaryotic membrane proteins in Saccharomyces cerevisiae.
Nature protocols 2008;3(5):784-98.
2007: Tara Hessa; Nadja M Meindl-Beinker; Andreas Bernsel; Hyun Kim; Yoko Sato; Mirjam Lerch-Bader; IngMarie Nilsson; Stephen H White; Gunnar von Heijne
Molecular code for transmembrane-helix recognition by the Sec61 translocon.
Nature 2007;450(7172):1026-30.
2007: Erik Granseth; Susanna Seppälä; Mikaela Rapp; Daniel O Daley; Gunnar von Heijne
Membrane protein structural biology--how far can the bugs take us?
Molecular membrane biology 2007;24(5-6):329-32.
2007: Simon Newstead; Hyun Kim; Gunnar von Heijne; So Iwata; David Drew
High-throughput fluorescent-based optimization of eukaryotic membrane protein overexpression and purification in Saccharomyces cerevisiae.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(35):13936-41.
2007: Filippa Stenberg; Gunnar von Heijne; Daniel O Daley
Assembly of the cytochrome bo3 complex.
Journal of molecular biology 2007;371(3):765-73.
2007: Carolina Boekel Lundin; Sofia Johansson; Arthur E Johnson; Jan Näslund; Gunnar von Heijne; IngMarie Nilsson
Stable insertion of Alzheimer Abeta peptide into the ER membrane strongly correlates with its length.
FEBS letters 2007;581(20):3809-13.
2007: Gunnar von Heijne
Membrane proteins up for grabs.
Nature biotechnology 2007;25(6):646-7.
2007: Liyan Zhang; Yoko Sato; Tara Hessa; Gunnar von Heijne; Jong-Kook Lee; Itsuo Kodama; Masao Sakaguchi; Nobuyuki Uozumi
Contribution of hydrophobic and electrostatic interactions to the membrane integration of the Shaker K+ channel voltage sensor domain.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(20):8263-8.
2007: Gunnar von Heijne
Formation of transmembrane helices in vivo--is hydrophobicity all that matters?
The Journal of general physiology 2007;129(5):353-6.
2007: Mikaela Rapp; Susanna Seppälä; Erik Granseth; Gunnar von Heijne
Emulating membrane protein evolution by rational design.
Science (New York, N.Y.) 2007;315(5816):1282-4.
2007: Arne Elofsson; Gunnar von Heijne
Membrane protein structure: prediction versus reality.
Annual review of biochemistry 2007;76():125-40.
2007: Olof Emanuelsson; Søren Brunak; Gunnar von Heijne; Henrik Nielsen
Locating proteins in the cell using TargetP, SignalP and related tools.
Nature protocols 2007;2(4):953-71.
2006: Gunnar von Heijne
Membrane-protein topology.
Nature reviews. Molecular cell biology 2006;7(12):909-18.
2006: Nadja M Meindl-Beinker; Carolina Boekel Lundin; IngMarie Nilsson; Stephen H White; Gunnar von Heijne
Asn- and Asp-mediated interactions between transmembrane helices during translocon-mediated membrane protein assembly.
EMBO reports 2006;7(11):1111-6.
2006: Hyun Kim; Karin Melén; Marie Österberg; Gunnar von Heijne
A global topology map of the Saccharomyces cerevisiae membrane proteome.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(30):11142-7.
2006: Marie Österberg; Hyun Kim; Jonas Warringer; Karin Melén; Anders Blomberg; Gunnar von Heijne
Phenotypic effects of membrane protein overexpression in Saccharomyces cerevisiae.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(30):11148-53.
2006: Mauro Amico; michele finelli; Ivan Rossi; Andrea Zauli; Arne Elofsson; Håkan Viklund; Gunnar von Heijne; David Jones; Anders Krogh; Piero Fariselli; Pier Luigi Martelli; Rita Casadio
PONGO: a web server for multiple predictions of all-alpha transmembrane proteins.
Nucleic acids research 2006;34(Web Server issue):W169-72.
2006: Carolina Boekel Lundin; Rickard Nordström; Klaus Wagner; Christian Windpassinger; Helena Andersson; Gunnar von Heijne; IngMarie Nilsson
Membrane topology of the human seipin protein.
FEBS letters 2006;580(9):2281-4.
2006: Paola Marani; Samuel Wagner; Louise Baars; Pierre Genevaux; Jan-Willem de Gier; IngMarie Nilsson; Rita Casadio; Gunnar von Heijne
New Escherichia coli outer membrane proteins identified through prediction and experimental verification.
Protein science : a publication of the Protein Society 2006;15(4):884-9.
2006: Mikaela Rapp; Erik Granseth; Susanna Seppälä; Gunnar von Heijne
Identification and evolution of dual-topology membrane proteins.
Nature structural & molecular biology 2006;13(2):112-6.
2005: Andrey L Karamyshev; Daniel J Kelleher; Reid Gilmore; Arthur E Johnson; Gunnar von Heijne; Ingmarie Nilsson
Mapping the interaction of the STT3 subunit of the oligosaccharyl transferase complex with nascent polypeptide chains.
The Journal of biological chemistry 2005;280(49):40489-93.
2005: Arsenio Villarejo; Stefan Burén; Susanne Larsson; Annabelle Déjardin; Magnus Monné; Charlotta Rudhe; Jan Karlsson; Stefan Jansson; Patrice Lerouge; Norbert Rolland; Gunnar von Heijne; Markus Grebe; Laszlo Bako; Göran Samuelsson
Evidence for a protein transported through the secretory pathway en route to the higher plant chloroplast.
Nature cell biology 2005;7(12):1224-31.
2005: Hanna Laudon; Emil M Hansson; Karin Melén; Anna Bergman; Mark Farmery; Bengt Winblad; Urban Lendahl; Gunnar von Heijne; Jan Näslund
A nine-transmembrane domain topology for presenilin 1.
The Journal of biological chemistry 2005;280(42):35352-60.
2005: J Alfredo Freites; Douglas J Tobias; Gunnar von Heijne; Stephen H White
Interface connections of a transmembrane voltage sensor.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(42):15059-64.
2005: Filippa Stenberg; Peter Chovanec; Sarah Maslen; Carol V Robinson; Leopold L Ilag; Gunnar von Heijne; Daniel O Daley
Protein complexes of the Escherichia coli cell envelope.
The Journal of biological chemistry 2005;280(41):34409-19.
2005: Boris Pasche; Thomas J Knobloch; Yansong Bian; Junjian Liu; Sharbani Phukan; Diana Rosman; Virginia G Kaklamani; Lisa Baddi; Farida S Siddiqui; Wendy Frankel; Thomas W Prior; David E Schuller; Amit Agrawal; Jas Lang; M Eileen Dolan; Everett E Vokes; William Stratton Lane; Chiang-Ching Huang; Trinidad Caldes; Antonio Di Cristofano; Heather Hampel; IngMarie Nilsson; Gunnar von Heijne; Riccardo Fodde; Vundavalli Murty; Albert de La Chapelle; Christopher M Weghorst
Somatic acquisition and signaling of TGFBR1*6A in cancer.
JAMA : the journal of the American Medical Association 2005;294(13):1634-46.
2005: Gunnar von Heijne
Helices on the move.
Nature structural & molecular biology 2005;12(10):834-5.
2005: Claudine Médigue; Evelyne Krin; Géraldine Pascal; Valérie Barbe; Andreas Bernsel; Philippe N Bertin; Frankie Cheung; Stéphane Cruveiller; Salvino D'Amico; Angela Duilio; Gang Fang; Georges Feller; Christine Ho; Sophie Mangenot; Gennaro Marino; Johan Nilsson; Ermenegilda Parrilli; Eduardo P C Rocha; Zoé Rouy; Agnieszka Sekowska; Maria Luisa Tutino; David Vallenet; Gunnar von Heijne; Antoine Danchin
Coping with cold: the genome of the versatile marine Antarctica bacterium Pseudoalteromonas haloplanktis TAC125.
Genome research 2005;15(10):1325-35.
2005: Erik Granseth; Daniel O Daley; Mikaela Rapp; Karin Melén; Gunnar von Heijne
Experimentally constrained topology models for 51,208 bacterial inner membrane proteins.
Journal of molecular biology 2005;352(3):489-94.
2005: Johan Nilsson; Bengt Persson; Gunnar von Heijne
Comparative analysis of amino acid distributions in integral membrane proteins from 107 genomes.
Proteins 2005;60(4):606-16.
2005: Stephen H White; Gunnar von Heijne
Transmembrane helices before, during, and after insertion.
Current opinion in structural biology 2005;15(4):378-86.
2005: Gunnar von Heijne
Microbiology. Translocation of anthrax toxin: lord of the rings.
Science (New York, N.Y.) 2005;309(5735):709-10.
2005: Andreas Bernsel; Gunnar von Heijne
Improved membrane protein topology prediction by domain assignments.
Protein science : a publication of the Protein Society 2005;14(7):1723-8.
2005: Daniel O Daley; Mikaela Rapp; Erik Granseth; Karin Melén; David Drew; Gunnar von Heijne
Global topology analysis of the Escherichia coli inner membrane proteome.
Science (New York, N.Y.) 2005;308(5726):1321-3.
2005: Hyun Kim; Gunnar von Heijne; IngMarie Nilsson
Membrane topology of the STT3 subunit of the oligosaccharyl transferase complex.
The Journal of biological chemistry 2005;280(21):20261-7.
2005: Jian-Ke Tie; Christopher Nicchitta; Gunnar von Heijne; Darrel W Stafford
Membrane topology mapping of vitamin K epoxide reductase by in vitro translation/cotranslocation.
The Journal of biological chemistry 2005;280(16):16410-6.
2005: Bo Ding; Björn Kull; Zhurong Liu; Salim Mottagui-Tabar; Håkan Thonberg; Harvest F Gu; Anthony J Brookes; Lars Grundemar; Christina Karlsson; Anders Hamsten; Peter Arner; Claes-Göran Ostenson; Suad Efendic; Magnus Monné; Gunnar von Heijne; Per Eriksson; Claes Wahlestedt
Human neuropeptide Y signal peptide gain-of-function polymorphism is associated with increased body mass index: possible mode of function.
Regulatory peptides 2005;127(1-3):45-53.
2005: Tara Hessa; Stephen H White; Gunnar von Heijne
Membrane insertion of a potassium-channel voltage sensor.
Science (New York, N.Y.) 2005;307(5714):1427.
2005: Erik Granseth; Gunnar von Heijne; Arne Elofsson
A study of the membrane-water interface region of membrane proteins.
Journal of molecular biology 2005;346(1):377-85.
2005: Tara Hessa; Hyun Kim; Karl Bihlmaier; Carolina Boekel Lundin; Jorrit Boekel; Helena Andersson; IngMarie Nilsson; Stephen H White; Gunnar von Heijne
Recognition of transmembrane helices by the endoplasmic reticulum translocon.
Nature 2005;433(7024):377-81.
2005: Joen Luirink; Gunnar von Heijne; Edith N G Houben; Jan-Willem de Gier
Biogenesis of inner membrane proteins in Escherichia coli.
Annual review of microbiology 2005;59():329-55.
2005: Magnus Monné; Tara Hessa; Laura Thissen; Gunnar von Heijne
Competition between neighboring topogenic signals during membrane protein insertion into the ER.
The FEBS journal 2005;272(1):28-36.
2004: Susanne Kerje; Preety Sharma; Ulrika Gunnarsson; Hyun Kim; Sonchita Bagchi; Robert Fredriksson; Karin Schütz; Per Jensen; Gunnar von Heijne; Ron Okimoto; Leif Andersson
The Dominant white, Dun and Smoky color variants in chicken are associated with insertion/deletion polymorphisms in the PMEL17 gene.
Genetics 2004;168(3):1507-18.
2004: Stephen H White; Gunnar von Heijne
The machinery of membrane protein assembly.
Current opinion in structural biology 2004;14(4):397-404.
2004: Jannick Dyrløv Bendtsen; Henrik Nielsen; Gunnar von Heijne; Søren Brunak
Improved prediction of signal peptides: SignalP 3.0.
Journal of molecular biology 2004;340(4):783-95.
2004: Anne Stefansson; Annika Armulik; IngMarie Nilsson; Gunnar von Heijne; Staffan Johansson
Determination of N- and C-terminal borders of the transmembrane domain of integrin subunits.
The Journal of biological chemistry 2004;279(20):21200-5.
2004: Jannick Dyrløv Bendtsen; Lars Jensen; Nikolaj Blom; Gunnar von Heijne; Søren Brunak
Feature-based prediction of non-classical and leaderless protein secretion.
Protein engineering, design & selection : PEDS 2004;17(4):349-56.
2004: Mikaela Rapp; David Drew; Daniel O Daley; Johan Nilsson; Tiago Carvalho; Karin Melén; Jan-Willem de Gier; Gunnar von Heijne
Experimentally based topology models for E. coli inner membrane proteins.
Protein science : a publication of the Protein Society 2004;13(4):937-45.
2003: Marika Hermansson; Gunnar von Heijne
Inter-helical hydrogen bond formation during membrane protein integration into the ER membrane.
Journal of molecular biology 2003;334(4):803-9.
2003: Isabelle Westerlund; Gunnar von Heijne; Olof Emanuelsson
LumenP--a neural network predictor for protein localization in the thylakoid lumen.
Protein science : a publication of the Protein Society 2003;12(10):2360-6.
2003: Helena Andersson; Aaron M D'Antona; Debra A Kendall; Gunnar von Heijne; Chen-Ni Chin
Membrane assembly of the cannabinoid receptor 1: impact of a long N-terminal tail.
Molecular pharmacology 2003;64(3):570-7.
2003: IngMarie Nilsson; Arthur E Johnson; Gunnar von Heijne
How hydrophobic is alanine?
The Journal of biological chemistry 2003;278(32):29389-93.
2003: Agnieszka S Juncker; Hanni Willenbrock; Gunnar von Heijne; Søren Brunak; Henrik Nielsen; Anders Krogh
Prediction of lipoprotein signal peptides in Gram-negative bacteria.
Protein science : a publication of the Protein Society 2003;12(8):1652-62.
2003: Olof Emanuelsson; Arne Elofsson; Gunnar von Heijne; Susana Cristóbal
In silico prediction of the peroxisomal proteome in fungi, plants and animals.
Journal of molecular biology 2003;330(2):443-56.
2003: Hyun Kim; Qi Yan; Gunnar von Heijne; Gregory A Caputo; William J Lennarz
Determination of the membrane topology of Ost4p and its subunit interactions in the oligosaccharyltransferase complex in Saccharomyces cerevisiae.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(13):7460-4.
2003: IngMarie Nilsson; Daniel J Kelleher; Yiwei Miao; Yuanlong Shao; Gert Kreibich; Reid Gilmore; Gunnar von Heijne; Arthur E Johnson
Photocross-linking of nascent chains to the STT3 subunit of the oligosaccharyltransferase complex.
The Journal of cell biology 2003;161(4):715-25.
2003: Marika Lundin; Magnus Monné; Anders Widell; Gunnar von Heijne; Mats A A Persson
Topology of the membrane-associated hepatitis C virus protein NS4B.
Journal of virology 2003;77(9):5428-38.
2003: Karin Melén; Anders Krogh; Gunnar von Heijne
Reliability measures for membrane protein topology prediction algorithms.
Journal of molecular biology 2003;327(3):735-44.
2003: Hyun Kim; Karin Melén; Gunnar von Heijne
Topology models for 37 Saccharomyces cerevisiae membrane proteins based on C-terminal reporter fusions and predictions.
The Journal of biological chemistry 2003;278(12):10208-13.
2003: Tara Hessa; Magnus Monné; Gunnar von Heijne
Stop-transfer efficiency of marginally hydrophobic segments depends on the length of the carboxy-terminal tail.
EMBO reports 2003;4(2):178-83.
2003: Gunnar von Heijne
Membrane protein assembly in vivo.
Advances in protein chemistry 2003;63():1-18.
2002: Johan Nilsson; Bengt Persson; Gunnar von Heijne
Prediction of partial membrane protein topologies using a consensus approach.
Protein science : a publication of the Protein Society 2002;11(12):2974-80.
2002: Marçal Vilar; Ana Sauri; Magnus Monné; José F Marcos; Gunnar von Heijne; Enrique Perez-Paya; Ismael Mingarro
Insertion and topology of a plant viral movement protein in the endoplasmic reticulum membrane.
The Journal of biological chemistry 2002;277(26):23447-52.
2002: Chen-Ni Chin; Gunnar von Heijne; Jan-Willem de Gier
Membrane proteins: shaping up.
Trends in biochemical sciences 2002;27(5):231-4.
2002: IngMarie Nilsson; Arthur E Johnson; Gunnar von Heijne
Cleavage of a tail-anchored protein by signal peptidase.
FEBS letters 2002;516(1-3):106-8.
2002: David Drew; Dan Sjöstrand; Johan Nilsson; Thomas Urbig; Chen-Ni Chin; Jan-Willem de Gier; Gunnar von Heijne
Rapid topology mapping of Escherichia coli inner-membrane proteins by prediction and PhoA/GFP fusion analysis.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(5):2690-5.
2002: Maria Hedman; Hans De Loof; Gunnar von Heijne; Arne Elofsson
Improved detection of homologous membrane proteins by inclusion of information from topology predictions.
Protein science : a publication of the Protein Society 2002;11(3):652-8.
2002: Jean-Benoit Peltier; Olof Emanuelsson; Dario E Kalume; Jimmy Ytterberg; Giulia Friso; Andrea Rudella; David A Liberles; Linda Söderberg; Peter Roepstorff; Gunnar von Heijne; Klaas J van Wijk
Central functions of the lumenal and peripheral thylakoid proteome of Arabidopsis determined by experimentation and genome-wide prediction.
The Plant cell 2002;14(1):211-36.
2001: Olof Emanuelsson; Gunnar von Heijne
Prediction of organellar targeting signals.
Biochimica et biophysica acta 2001;1541(1-2):114-9.
2001: Marika Hermansson; Magnus Monné; Gunnar von Heijne
Formation of helical hairpins during membrane protein integration into the endoplasmic reticulum membrane. Role of the N and C-terminal flanking regions.
Journal of molecular biology 2001;313(5):1171-9.
2001: IngMarie Nilsson; Henna Ohvo-Rekilä; J Peter Slotte; Arthur E Johnson; Gunnar von Heijne
Inhibition of protein translocation across the endoplasmic reticulum membrane by sterols.
The Journal of biological chemistry 2001;276(45):41748-54.
2001: David Drew; Gunnar von Heijne; Pär Nordlund; Jan-Willem de Gier
Green fluorescent protein as an indicator to monitor membrane protein overexpression in Escherichia coli.
FEBS letters 2001;507(2):220-4.
2001: A Sääf; Louise Baars; Gunnar von Heijne
The internal repeats in the Na+/Ca2+ exchanger-related Escherichia coli protein YrbG have opposite membrane topologies.
The Journal of biological chemistry 2001;276(22):18905-7.
2001: Magnus Monné; Gunnar von Heijne
Effects of 'hydrophobic mismatch' on the location of transmembrane helices in the ER membrane.
FEBS letters 2001;496(2-3):96-100.
2001: Anders Krogh; B Larsson; Gunnar von Heijne; Erik L L Sonnhammer
Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes.
Journal of molecular biology 2001;305(3):567-80.
2001: Olof Emanuelsson; Gunnar von Heijne; G Schneider
Analysis and prediction of mitochondrial targeting peptides.
Methods in cell biology 2001;65():175-87.
2000: J Nilsson; B Persson; Gunnar von Heijne
Consensus predictions of membrane protein topology.
FEBS letters 2000;486(3):267-9.
2000: Chen-Ni Chin; Gunnar von Heijne
Charge pair interactions in a model transmembrane helix in the ER membrane.
Journal of molecular biology 2000;303(1):1-5.
2000: A Sääf; Marika Hermansson; Gunnar von Heijne
Formation of cytoplasmic turns between two closely spaced transmembrane helices during membrane protein integration into the ER membrane.
Journal of molecular biology 2000;301(1):191-7.
2000: Olof Emanuelsson; Henrik Nielsen; Søren Brunak; Gunnar von Heijne
Predicting subcellular localization of proteins based on their N-terminal amino acid sequence.
Journal of molecular biology 2000;300(4):1005-16.
2000: IngMarie Nilsson; Gunnar von Heijne
Glycosylation efficiency of Asn-Xaa-Thr sequons depends both on the distance from the C terminus and on the presence of a downstream transmembrane segment.
The Journal of biological chemistry 2000;275(23):17338-43.
2000: IngMarie Nilsson; S Witt; H Kiefer; Ismael Mingarro; Gunnar von Heijne
Distant downstream sequence determinants can control N-tail translocation during protein insertion into the endoplasmic reticulum membrane.
The Journal of biological chemistry 2000;275(9):6207-13.
2000: Pier A Scotti; Malene L Urbanus; Josef Brunner; Jan-Willem de Gier; Gunnar von Heijne; chris van der does; Arnold J M Driessen; Bauke Oudega; Joen Luirink
YidC, the Escherichia coli homologue of mitochondrial Oxa1p, is a component of the Sec translocase.
The EMBO journal 2000;19(4):542-9.
2000: Ismael Mingarro; IngMarie Nilsson; P Whitley; Gunnar von Heijne
Different conformations of nascent polypeptides during translocation across the ER membrane.
BMC cell biology 2000;1():3.
1999: Annika Armulik; I Nilsson; Gunnar von Heijne; Staffan Johansson
Determination of the border between the transmembrane and cytoplasmic domains of human integrin subunits.
The Journal of biological chemistry 1999;274(52):37030-4.
1999: Magnus Monné; IngMarie Nilsson; Arne Elofsson; Gunnar von Heijne
Turns in transmembrane helices: determination of the minimal length of a "helical hairpin" and derivation of a fine-grained turn propensity scale.
Journal of molecular biology 1999;293(4):807-14.
1999: Gunnar von Heijne
A Day in the Life of Dr K. or How I Learned to Stop Worrying and Love Lysozyme: a tragedy in six acts.
Journal of molecular biology 1999;293(2):367-79.
1999: P Braun; Gunnar von Heijne
The aromatic residues Trp and Phe have different effects on the positioning of a transmembrane helix in the microsomal membrane.
Biochemistry 1999;38(30):9778-82.
1999: A Sääf; M Johansson; Ewa Wallin; Gunnar von Heijne
Divergent evolution of membrane protein topology: the Escherichia coli RnfA and RnfE homologues.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(15):8540-4.
1999: Susana Cristóbal; Pier A Scotti; Joen Luirink; Gunnar von Heijne; Jan-Willem de Gier
The signal recognition particle-targeting pathway does not necessarily deliver proteins to the sec-translocase in Escherichia coli.
The Journal of biological chemistry 1999;274(29):20068-70.
1999: Magnus Monné; Guro Gafvelin; R Nilsson; Gunnar von Heijne
N-tail translocation in a eukaryotic polytopic membrane protein: synergy between neighboring transmembrane segments.
European journal of biochemistry / FEBS 1999;263(1):264-9.
1999: Susana Cristóbal; Jan-Willem de Gier; Henrik Nielsen; Gunnar von Heijne
Competition between Sec- and TAT-dependent protein translocation in Escherichia coli.
The EMBO journal 1999;18(11):2982-90.
1999: Olof Emanuelsson; Henrik Nielsen; Gunnar von Heijne
ChloroP, a neural network-based method for predicting chloroplast transit peptides and their cleavage sites.
Protein science : a publication of the Protein Society 1999;8(5):978-84.
1999: Magnus Monné; Marika Hermansson; Gunnar von Heijne
A turn propensity scale for transmembrane helices.
Journal of molecular biology 1999;288(1):141-5.
1999: Henrik Nielsen; Søren Brunak; Gunnar von Heijne
Machine learning approaches for the prediction of signal peptides and other protein sorting signals.
Protein engineering 1999;12(1):3-9.
1998: IngMarie Nilsson; Gunnar von Heijne
Breaking the camel's back: proline-induced turns in a model transmembrane helix.
Journal of molecular biology 1998;284(4):1185-9.
1998: Magnus Monné; IngMarie Nilsson; M Johansson; N Elmhed; Gunnar von Heijne
Positively and negatively charged residues have different effects on the position in the membrane of a model transmembrane helix.
Journal of molecular biology 1998;284(4):1177-83.
1998: IngMarie Nilsson; A Sääf; P Whitley; Guro Gafvelin; C Waller; Gunnar von Heijne
Proline-induced disruption of a transmembrane alpha-helix in its natural environment.
Journal of molecular biology 1998;284(4):1165-75.
1998: Jan-Willem de Gier; Pier A Scotti; A Sääf; QA Valent; A Kuhn; Joen Luirink; Gunnar von Heijne
Differential use of the signal recognition particle translocase targeting pathway for inner membrane protein assembly in Escherichia coli.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(25):14646-51.
1998: A Sääf; Magnus Monné; Jan-Willem de Gier; Gunnar von Heijne
Membrane topology of the 60-kDa Oxa1p homologue from Escherichia coli.
The Journal of biological chemistry 1998;273(46):30415-8.
1998: K Seshadri; R Garemyr; Ewa Wallin; Gunnar von Heijne; Arne Elofsson
Architecture of beta-barrel membrane proteins: analysis of trimeric porins.
Protein science : a publication of the Protein Society 1998;7(9):2026-32.
1998: QA Valent; Pier A Scotti; Stephen High; Jan-Willem de Gier; Gunnar von Heijne; Georg Lentzen; Wolfgang Wintermeyer; Bauke Oudega; Joen Luirink
The Escherichia coli SRP and SecB targeting pathways converge at the translocon.
The EMBO journal 1998;17(9):2504-12.
1998: Ewa Wallin; Gunnar von Heijne
Genome-wide analysis of integral membrane proteins from eubacterial, archaean, and eukaryotic organisms.
Protein science : a publication of the Protein Society 1998;7(4):1029-38.
1998: A Sääf; Ewa Wallin; Gunnar von Heijne
Stop-transfer function of pseudo-random amino acid segments during translocation across prokaryotic and eukaryotic membranes.
European journal of biochemistry / FEBS 1998;251(3):821-9.
1997: Ismael Mingarro; Arne Elofsson; Gunnar von Heijne
Helix-helix packing in a membrane-like environment.
Journal of molecular biology 1997;272(4):633-41.
1997: Henrik Nielsen; J Engelbrecht; Søren Brunak; Gunnar von Heijne
A neural network method for identification of prokaryotic and eukaryotic signal peptides and prediction of their cleavage sites.
International journal of neural systems 1997;8(5-6):581-99.
1997: Ismael Mingarro; Gunnar von Heijne; P Whitley
Membrane-protein engineering.
Trends in biotechnology 1997;15(10):432-7.
1997: QA Valent; Jan-Willem de Gier; Gunnar von Heijne; D A Kendall; Corinne M Ten Hagen-Jongman; Bauke Oudega; Joen Luirink
Nascent membrane and presecretory proteins synthesized in Escherichia coli associate with signal recognition particle and trigger factor.
Molecular microbiology 1997;25(1):53-64.
1997: M Cserzö; Ewa Wallin; Istvan Simon; Gunnar von Heijne; A Elofsson
Prediction of transmembrane alpha-helices in prokaryotic membrane proteins: the dense alignment surface method.
Protein engineering 1997;10(6):673-6.
1997: Jan-Willem de Gier; QA Valent; Gunnar von Heijne; Joen Luirink
The E. coli SRP: preferences of a targeting factor.
FEBS letters 1997;408(1):1-4.
1997: Gunnar von Heijne
Getting greasy: how transmembrane polypeptide segments integrate into the lipid bilayer.
Molecular microbiology 1997;24(2):249-53.
1997: Ewa Wallin; T Tsukihara; S Yoshikawa; Gunnar von Heijne; Arne Elofsson
Architecture of helix bundle membrane proteins: an analysis of cytochrome c oxidase from bovine mitochondria.
Protein science : a publication of the Protein Society 1997;6(4):808-15.
1997: Guro Gafvelin; M Sakaguchi; H Andersson; Gunnar von Heijne
Topological rules for membrane protein assembly in eukaryotic cells.
The Journal of biological chemistry 1997;272(10):6119-27.
1997: Henrik Nielsen; J Engelbrecht; Søren Brunak; Gunnar von Heijne
Identification of prokaryotic and eukaryotic signal peptides and prediction of their cleavage sites.
Protein engineering 1997;10(1):1-6.
1996: H Kiefer; J Krieger; J D Olszewski; Gunnar von Heijne; G D Prestwich; H Breer
Expression of an olfactory receptor in Escherichia coli: purification, reconstitution, and ligand binding.
Biochemistry 1996;35(50):16077-84.
1996: Jan-Willem de Gier; P Mansournia; QA Valent; G J Phillips; Joen Luirink; Gunnar von Heijne
Assembly of a cytoplasmic membrane protein in Escherichia coli is dependent on the signal recognition particle.
FEBS letters 1996;399(3):307-9.
1996: H Andersson; I Nilsson; Gunnar von Heijne
Calnexin can interact with N-linked glycans located close to the endoplasmic reticulum membrane.
FEBS letters 1996;397(2-3):321-4.
1996: M Johansson; Gunnar von Heijne
Membrane topology of Kch, a putative K+ channel from Escherichia coli.
The Journal of biological chemistry 1996;271(42):25912-5.
1996: Ismael Mingarro; P Whitley; M A Lemmon; Gunnar von Heijne
Ala-insertion scanning mutagenesis of the glycophorin A transmembrane helix: a rapid way to map helix-helix interactions in integral membrane proteins.
Protein science : a publication of the Protein Society 1996;5(7):1339-41.
1996: P Whitley; E Grahn; U Kutay; Tom A Rapoport; Gunnar von Heijne
A 12-residue-long polyleucine tail is sufficient to anchor synaptobrevin to the endoplasmic reticulum membrane.
The Journal of biological chemistry 1996;271(13):7583-6.
1996: P Whitley; I M Nilsson; Gunnar von Heijne
A nascent secretory protein may traverse the ribosome/endoplasmic reticulum translocase complex as an extended chain.
The Journal of biological chemistry 1996;271(11):6241-4.
1996: Henrik Nielsen; J Engelbrecht; Gunnar von Heijne; Søren Brunak
Defining a similarity threshold for a functional protein sequence pattern: the signal peptide cleavage site.
Proteins 1996;24(2):165-77.
1995: P Whitley; Guro Gafvelin; Gunnar von Heijne
SecA-independent translocation of the periplasmic N-terminal tail of an Escherichia coli inner membrane protein. Position-specific effects on translocation of positively charged residues and construction of a protein with a C-terminal translocation signal.
The Journal of biological chemistry 1995;270(50):29831-5.
1995: P Whitley; A Sääf; Guro Gafvelin; M Johansson; Ewa Wallin; Gunnar von Heijne
Membrane protein anchors and polytopic determinants.
Biochemical Society transactions 1995;23(4):965-7.
1995: Ewa Wallin; Gunnar von Heijne
Properties of N-terminal tails in G-protein coupled receptors: a statistical study.
Protein engineering 1995;8(7):693-8.
1995: A Sääf; H Andersson; Guro Gafvelin; Gunnar von Heijne
SecA-dependence of the translocation of a large periplasmic loop in the Escherichia coli MalF inner membrane protein is a function of sequence context.
Molecular membrane biology 1995;12(2):209-15.
1994: P Whitley; IngMarie Nilsson; Gunnar von Heijne
De novo design of integral membrane proteins.
Nature structural biology 1994;1(12):858-62.
1994: Gunnar von Heijne
Sec-independent protein insertion into the inner E. coli membrane. A phenomenon in search of an explanation.
FEBS letters 1994;346(1):69-72.
1994: H Andersson; Gunnar von Heijne
Membrane protein topology: effects of delta mu H+ on the translocation of charged residues explain the 'positive inside' rule.
The EMBO journal 1994;13(10):2267-72.
1994: Guro Gafvelin; Gunnar von Heijne
Topological "frustration" in multispanning E. coli inner membrane proteins.
Cell 1994;77(3):401-12.
1993: P Whitley; L Nilsson; Gunnar von Heijne
Three-dimensional model for the membrane domain of Escherichia coli leader peptidase based on disulfide mapping.
Biochemistry 1993;32(33):8534-9.