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Linda Von Tungeln

Research Profile

Living Beings

Chemicals & Drugs

Anatomy

Procedures

Physiology

Biotransformation

Disorders

Liver Neoplasms, Experimental

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Publications

TOP 3
Linda S Von Tungeln; William M Witt; Daniel R Doerge; Gonçalo Gamboa da Costa; Igor Koturbash; M Matilde Marques; Igor P Pogribny; Frederick A Beland
Tumorigenicity of acrylamide and its metabolite glycidamide in the neonatal mouse bioassay.
Qin Zhang; Ronald P Brown; Gonçalo Gamboa da Costa; Cristina C Jacob; Linda S Von Tungeln; Peter L Goering
Urinary biomarker detection of melamine- and cyanuric acid-induced kidney injury in rats.
Gonçalo Gamboa da Costa; Nicholas R Hasbrouck; David G Hattan; Cristina C Jacob; Greg R Olson; renate reimschuessel; Linda S Von Tungeln; Frederick A Beland
Dose-response assessment of nephrotoxicity from a twenty-eight-day combined-exposure to melamine and cyanuric acid in F344 rats.

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All Publications

2012: Linda S Von Tungeln; William M Witt; Daniel R Doerge; Gonçalo Gamboa da Costa; Igor Koturbash; M Matilde Marques; Igor P Pogribny; Frederick A Beland
Tumorigenicity of acrylamide and its metabolite glycidamide in the neonatal mouse bioassay.
International journal of cancer. Journal international du cancer 2012;131(9):2008-15.
2012: Qin Zhang; Ronald P Brown; Gonçalo Gamboa da Costa; Cristina C Jacob; Linda S Von Tungeln; Peter L Goering
Urinary biomarker detection of melamine- and cyanuric acid-induced kidney injury in rats.
Toxicological sciences : an official journal of the Society of Toxicology 2012;129(1):1-8.
2012: Gonçalo Gamboa da Costa; Nicholas R Hasbrouck; David G Hattan; Cristina C Jacob; Greg R Olson; renate reimschuessel; Linda S Von Tungeln; Frederick A Beland
Dose-response assessment of nephrotoxicity from a twenty-eight-day combined-exposure to melamine and cyanuric acid in F344 rats.
Toxicology and applied pharmacology 2012;262(2):99-106.
2012: Cristina C Jacob; Michelle Vanlandingham; Linda S Von Tungeln; Frederick A Beland; Gonçalo Gamboa da Costa
Pharmacokinetics of melamine and cyanuric acid and their combinations in F344 rats.
Toxicological sciences : an official journal of the Society of Toxicology 2012;126(2):317-24.
2011: Linda S Von Tungeln; Kellie A Woodling; Tong Zhou; Daniel R Doerge; Kevin J Greenlees; Frederick A Beland
Benzocaine-induced methemoglobinemia in an acute-exposure rat model.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2011;49(10):2530-5.
2011: Cristina C Jacob; renate reimschuessel; Linda S Von Tungeln; Greg R Olson; Alan Warbritton; David G Hattan; Frederick A Beland; Gonçalo Gamboa da Costa
Dose-response assessment of nephrotoxicity from a 7-day combined exposure to melamine and cyanuric acid in F344 rats.
Toxicological sciences : an official journal of the Society of Toxicology 2011;119(2):391-7.
2009: Jinchun Sun; Linda S Von Tungeln; Wade Hines; Richard Beger
Identification of metabolite profiles of the catechol-O-methyl transferase inhibitor tolcapone in rat urine using LC/MS-based metabonomics analysis.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2009;877(24):2557-65.
2009: Linda S Von Tungeln; Mona I Churchwell; Daniel R Doerge; Joseph G Shaddock; Lynda J McGarrity; Robert H Heflich; Gonçalo Gamboa da Costa; M Matilde Marques; Frederick A Beland
DNA adduct formation and induction of micronuclei and mutations in B6C3F1/Tk mice treated neonatally with acrylamide or glycidamide.
International journal of cancer. Journal international du cancer 2009;124(9):2006-15.
2009: Varsha G Desai; Taewon Lee; Carrie L Moland; William S Branham; Linda S Von Tungeln; Frederick A Beland; James C Fuscoe
Effect of short-term exposure to zidovudine (AZT) on the expression of mitochondria-related genes in skeletal muscle of neonatal mice.
Mitochondrion 2009;9(1):9-16.
2009: Robert N McBurney; Wade M Hines; Linda S Von Tungeln; Laura K Schnackenberg; Richard D Beger; Carrie L Moland; Tao Han; James C Fuscoe; Ching-Wei Chang; James J Chen; Zhenqiang Su; Xiao-Hui Fan; Weida Tong; Shelagh A Booth; Raji Balasubramanian; Paul L Courchesne; Jennifer M Campbell; Armin Graber; Yu Guo; Peter J Juhasz; Tricin Y Li; Moira D Lynch; Nicole M Morel; Thomas N Plasterer; Edward J Takach; Chenhui Zeng; Frederick A Beland
The liver toxicity biomarker study: phase I design and preliminary results.
Toxicologic pathology 2009;37(1):52-64.
2007: Linda S Von Tungeln; Lee D Williams; Daniel R Doerge; Joseph G Shaddock; Lynda J McGarrity; Suzanne M Morris; Roberta A Mittelstaedt; Robert H Heflich; Frederick A Beland
Transplacental drug transfer and frequency of Tk and Hprt lymphocyte mutants and peripheral blood micronuclei in mice treated transplacentally with zidovudine and lamivudine.
Environmental and molecular mutagenesis 2007;48(3-4):258-69.
2005: Frederick A Beland; Mona I Churchwell; Linda S Von Tungeln; Shoujun Chen; Peter P Fu; Sandra J Culp; Bernadette Schoket; Erika Gyorffy; János Minárovits; Miriam C Poirier; Elise D Bowman; Ainsley Weston; Daniel R Doerge
High-performance liquid chromatography electrospray ionization tandem mass spectrometry for the detection and quantitation of benzo[a]pyrene-DNA adducts.
Chemical research in toxicology 2005;18(8):1306-15.
2005: Barbara L Parsons; Frederick A Beland; Linda S Von Tungeln; Robert R Delongchamp; Peter P Fu; Robert H Heflich
Levels of 4-aminobiphenyl-induced somatic H-ras mutation in mouse liver DNA correlate with potential for liver tumor development.
Molecular carcinogenesis 2005;42(4):193-201.
2004: Linda S Von Tungeln; Vasily N Dobrovolsky; Michelle E Bishop; Joseph G Shaddock; Robert H Heflich; Frederick A Beland
Frequency of Tk and Hprt lymphocyte mutants and bone marrow micronuclei in mice treated neonatally with zidovudine and didanosine.
Mutagenesis 2004;19(4):307-11.
2004: Roberta A Mittelstaedt; Linda S Von Tungeln; Joseph G Shaddock; Vasily N Dobrovolsky; Frederick A Beland; Robert H Heflich
Analysis of mutations in the Tk gene of Tk(+/-) mice treated as neonates with 3'-azido-3'-deoxythymidine (AZT).
Mutation research 2004;547(1-2):63-9.
2003: Lee D Williams; Linda S Von Tungeln; Frederick A Beland; Daniel R Doerge
Liquid chromatographic-mass spectrometric determination of the metabolism and disposition of the anti-retroviral nucleoside analogs zidovudine and lamivudine in C57BL/6N and B6C3F1 mice.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2003;798(1):55-62.
2003: Gonçalo Gamboa da Costa; Mona I Churchwell; L Patrice Hamilton; Linda S Von Tungeln; Frederick A Beland; M Matilde Marques; Daniel R Doerge
DNA adduct formation from acrylamide via conversion to glycidamide in adult and neonatal mice.
Chemical research in toxicology 2003;16(10):1328-37.
2002: Rao L Divi; Frederick A Beland; Peter P Fu; Linda S Von Tungeln; Bernadette Schoket; Johanna Eltz Camara; Monica Ghei; Nathaniel Rothman; Rashmi Sinha; Miriam C Poirier
Highly sensitive chemiluminescence immunoassay for benzo[a]pyrene-DNA adducts: validation by comparison with other methods, and use in human biomonitoring.
Carcinogenesis 2002;23(12):2043-9.
2002: Linda S Von Tungeln; Ping Yi; Thomas J Bucci; Victor M Samokyszyn; Ming W Chou; Fred F Kadlubar; Peter P Fu
Tumorigenicity of chloral hydrate, trichloroacetic acid, trichloroethanol, malondialdehyde, 4-hydroxy-2-nonenal, crotonaldehyde, and acrolein in the B6C3F(1) neonatal mouse.
Cancer letters 2002;185(1):13-9.
2002: Linda S Von Tungeln; L Patrice Hamilton; Vasily N Dobrovolsky; Michelle E Bishop; Joseph G Shaddock; Robert H Heflich; Frederick A Beland
Frequency of Tk and Hprt lymphocyte mutants and bone marrow micronuclei in B6C3F(1)/Tk+/- mice treated neonatally with zidovudine and lamivudine.
Carcinogenesis 2002;23(9):1427-32.
2000: Peter P Fu; Linda S Von Tungeln; George J Hammons; G McMahon; G Wogan; T J Flammang; Fred F Kadlubar
Metabolic activation capacity of neonatal mice in relation to the neonatal mouse tumorigenicity bioassay.
Drug metabolism reviews 2000;32(2):241-66.
1999: Linda S Von Tungeln; Qingsu Xia; Diogenes Herreno-Saenz; Thomas J Bucci; Robert H Heflich; Peter P Fu
Tumorigenicity of nitropolycyclic aromatic hydrocarbons in the neonatal B6C3F1 mouse bioassay and characterization of ras mutations in liver tumors from treated mice.
Cancer letters 1999;146(1):1-7.
1999: Linda S Von Tungeln; Qingsu Xia; Thomas J Bucci; Robert H Heflich; Peter P Fu
Tumorigenicity and liver tumor ras-protooncogene mutations in CD-1 mice treated neonatally with 1- and 3-nitrobenzo[a]pyrene and their trans-7,8-dihydrodiol and aminobenzo[a]pyrene metabolites.
Cancer letters 1999;137(2):137-43.
1998: Peter P Fu; Linda S Von Tungeln; LH Chiu; DJ Zhan; J Deck; Thomas J Bucci; J C Wang
Structure, tumorigenicity, microsomal metabolism, and DNA binding of 7-Nitrodibenz[a,h]anthracene.
Chemical research in toxicology 1998;11(8):937-45.
1998: Qingsu Xia; Ping Yi; DJ Zhan; Linda S Von Tungeln; Ronald W Hart; Robert H Heflich; Peter P Fu
Liver tumors induced in B6C3F1 mice by 7-chlorobenz[a]anthracene and 7-bromobenz[a]anthracene contain K-ras protooncogene mutations.
Cancer letters 1998;123(1):21-5.
1997: DJ Zhan; LH Chiu; Linda S Von Tungeln; Diogenes Herreno-Saenz; E Cheng; Frederick E Evans; Robert H Heflich; Peter P Fu
Characterization of DNA adducts in Chinese hamster ovary cells treated with mutagenic doses of 1- and 3-nitrosobenzo[a]pyrene and the trans-7,8-diol-anti-9,10-epoxides of 1- and 3-nitrobenzo[a]pyrene.
Mutation research 1997;379(1):43-52.
1997: Sandra J Culp; Dean W Roberts; G Talaska; Nicholas P Lang; Peter P Fu; Jackson Lay; Candee H Teitel; J E Snawder; Linda S Von Tungeln; Fred F Kadlubar
Immunochemical, 32P-postlabeling, and GC/MS detection of 4-aminobiphenyl-DNA adducts in human peripheral lung in relation to metabolic activation pathways involving pulmonary N-oxidation, conjugation, and peroxidation.
Mutation research 1997;378(1-2):97-112.
1997: Peter P Fu; F Y Qui; H Jung; Linda S Von Tungeln; DJ Zhan; M J Lee; Y S Wu; Robert H Heflich
Metabolism of isomeric nitrobenzo[a]pyrenes leading to DNA adducts and mutagenesis.
Mutation research 1997;376(1-2):43-51.
1996: Linda S Von Tungeln; Thomas J Bucci; Ronald W Hart; F F Kadlubar; Peter P Fu
Inhibitory effect of caloric restriction on tumorigenicity induced by 4-aminobiphenyl and 2-amino-1-methyl-6-phenylimidazo-[4,5-b]pyridine (PhIP) in the CD1 newborn mouse bioassay.
Cancer letters 1996;104(2):133-6.
1996: Peter P Fu; Linda S Von Tungeln; DJ Zhan; Thomas J Bucci
Potent tumorigenicity of 7-chlorobenz[a]anthracene and 7-bromobenz[a]anthracene in the neonatal B6C3F (1) male mouse.
Cancer letters 1996;101(1):37-42.
1994: Peter P Fu; D Herreno-Saenz; Linda S Von Tungeln; Jackson Lay; Y S Wu; J S Lai; F E Evans
DNA adducts and carcinogenicity of nitro-polycyclic aromatic hydrocarbons.
Environmental health perspectives 1994;102 Suppl 6():177-83.
1994: Peter P Fu; K L Dooley; Linda S Von Tungeln; Thomas J Bucci; Ronald W Hart; Fred F Kadlubar
Caloric restriction profoundly inhibits liver tumor formation after initiation by 6-nitrochrysene in male mice.
Carcinogenesis 1994;15(2):159-61.
1993: Peter P Fu; Y S Wu; Linda S Von Tungeln; J S Lai; M. Paul Chiarelli; F E Evans
Synthesis of 3-nitrobenzo[a]pyrene bay-region trans-7,8-diol anti-9,10-epoxide and the corresponding N2-deoxyguanosine adduct.
Chemical research in toxicology 1993;6(5):603-8.
1993: John B Sutherland; Peter P Fu; S K Yang; Linda S Von Tungeln; R P Casillas; Sidney A Crow; Carl E Cerniglia
Enantiomeric Composition of the trans-Dihydrodiols Produced from Phenanthrene by Fungi.
Applied and environmental microbiology 1993;59(7):2145-9.
1992: K L Dooley; Linda S Von Tungeln; Thomas J Bucci; Peter P Fu; Fred F Kadlubar
Comparative carcinogenicity of 4-aminobiphenyl and the food pyrolysates, Glu-P-1, IQ, PhIP, and MeIQx in the neonatal B6C3F1 male mouse.
Cancer letters 1992;62(3):205-9.
1991: S Y Yu; Robert H Heflich; Linda S Von Tungeln; K el-Bayoumy; Fred F Kadlubar; Peter P Fu
Comparative direct-acting mutagenicity of 1- and 2-nitropyrene: evidence for 2-nitropyrene mutagenesis by both guanine and adenine adducts.
Mutation research 1991;250(1-2):145-52.
1991: Peter P Fu; D W Miller; Linda S Von Tungeln; Matthew Bryant; Jackson Lay; K Huang; L Jones; F E Evans
Formation of C8-modified deoxyguanosine and C8-modified deoxyadenosine as major DNA adducts from 2-nitropyrene metabolism mediated by rat and mouse liver microsomes and cytosols.
Carcinogenesis 1991;12(4):609-16.
1991: Peter P Fu; Linda S Von Tungeln; L E Unruh; Y C Ni; Ming W Chou
Comparative regioselective and stereoselective metabolism of 7-chlorobenz[a]anthracene and 7-bromobenz[a]anthracene by mouse and rat liver microsomes.
Carcinogenesis 1991;12(3):371-8.
1990: Peter P Fu; H Jung; Linda S Von Tungeln; Robert H Heflich
Mutagenicity of mononitrodihydrobenzo[a]pyrenes.
Mutation research 1990;245(4):277-85.
1989: Robert H Heflich; L E Unruh; J R Thornton-Manning; Linda S Von Tungeln; Peter P Fu
Mutagenicity of 1-, 3- and 6-nitrosobenzo[a]pyrene in Salmonella typhimurium and Chinese hamster ovary cells.
Mutation research 1989;225(4):157-63.
1989: Linda S Von Tungeln; Peter P Fu
High-performance liquid chromatographic separation of ring-oxidized metabolites of nitro-polycyclic aromatic hydrocarbons.
Journal of chromatography 1989;461():315-26.
1988: Peter P Fu; Robert H Heflich; Linda S Von Tungeln; H Z Miranda; F E Evans
Microsomal metabolism of 1-nitrobenzo[e]pyrene to a highly mutagenic K-region dihydrodiol.
Carcinogenesis 1988;9(6):951-8.
1987: Ming W Chou; B X Wang; Linda S Von Tungeln; F A Beland; Peter P Fu
Induction of rat hepatic cytochromes P-450 by environmental nitropolycyclic aromatic hydrocarbons.
Biochemical pharmacology 1987;36(15):2449-54.
1985: Peter P Fu; Linda S Von Tungeln; Ming W Chou
Stereoselective metabolism of 7-chlorobenz(a)anthracene by rat liver microsomes. Absolute configurations and optical purities of trans-dihydrodiol metabolites.
Molecular pharmacology 1985;28(1):62-71.
1985: Peter P Fu; Linda S Von Tungeln; Ming W Chou
Metabolism of 9-nitroanthracene by rat liver microsomes: identification and mutagenicity of metabolites.
Carcinogenesis 1985;6(5):753-7.