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Timothy Vortherms

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Andrew M Swensen; Timothy A Vortherms; Michael F Jarvis; Lance Lee; Tao Li; Wende Niforatos; Richard J Perner; Michael R Schrimpf; Victoria E Scott; Steve McGaraughty
An automated electrophysiological assay for differentiating Ca(v)2.2 inhibitors based on state dependence and kinetics.
Xenia Beebe; Janel M Boyce-Rustay; Daria Darczak; Diana L Donnelly-Roberts; Pamela Franklin; Erica Gomez; Rodger F Henry; Richard Janis; Michael F Jarvis; Karen Kage; Kennan Marsh; Ivan Milicic; Marian T Namovic; Wende Niforatos; Gricelda Simler; Andrew O Stewart; Carol S Surowy; Andrew Swensen; Timothy A Vortherms; Jill M Wetter; Chengmin Zhong; Chang Z Zhu; Scott Baker; Victoria E Scott
Synthesis and SAR of 4-aminocyclopentapyrrolidines as N-type Ca²⁺ channel blockers with analgesic activity.
George A Doherty; Michael F Jarvis; Helmut Mack; Kennan Marsh; Victoria E Scott; Timothy A Vortherms; Jill M Wetter; Pramila Bhatia; Andrew O Stewart
Discovery of diphenyl lactam derivatives as N-type calcium channel blockers.

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2012: Andrew M Swensen; Timothy A Vortherms; Michael F Jarvis; Lance Lee; Tao Li; Wende Niforatos; Richard J Perner; Michael R Schrimpf; Victoria E Scott; Steve McGaraughty
An automated electrophysiological assay for differentiating Ca(v)2.2 inhibitors based on state dependence and kinetics.
Assay and drug development technologies 2012;10(6):542-50.
2012: Xenia Beebe; Janel M Boyce-Rustay; Daria Darczak; Diana L Donnelly-Roberts; Pamela Franklin; Erica Gomez; Rodger F Henry; Richard Janis; Michael F Jarvis; Karen Kage; Kennan Marsh; Ivan Milicic; Marian T Namovic; Wende Niforatos; Gricelda Simler; Andrew O Stewart; Carol S Surowy; Andrew Swensen; Timothy A Vortherms; Jill M Wetter; Chengmin Zhong; Chang Z Zhu; Scott Baker; Victoria E Scott
Synthesis and SAR of 4-aminocyclopentapyrrolidines as N-type Ca²⁺ channel blockers with analgesic activity.
Bioorganic & medicinal chemistry 2012;20(13):4128-39.
2012: George A Doherty; Michael F Jarvis; Helmut Mack; Kennan Marsh; Victoria E Scott; Timothy A Vortherms; Jill M Wetter; Pramila Bhatia; Andrew O Stewart
Discovery of diphenyl lactam derivatives as N-type calcium channel blockers.
Bioorganic & medicinal chemistry letters 2012;22(4):1716-8.
2011: Timothy A Vortherms; Di Zhang; Carol S Surowy; Andrew M Swensen; Rama Thimmapaya; C Brent Putman; Diana L Donnelly-Roberts; Richard S Janis; Michael F Jarvis; James T Limberis; Ruth L Martin; Marian T Namovic; Torben R Neelands; Wende Niforatos; Victoria E Scott
Comparative analysis of inactivated-state block of N-type (Ca(v)2.2) calcium channels.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2011;60(7):683-93.
2009: M I Strakhova; C A Cuff; Arlene M Manelli; Tracy L Carr; David G Witte; John L Baranowski; Timothy A Vortherms; Thomas R Miller; L Rundell; M J McPherson; R M Adair; A A Brito; B M Bettencourt; Betty B Yao; Jill M Wetter; Kennan Marsh; Huaqing Liu; Marlon D Cowart; Jorge D Brioni; Timothy A Esbenshade
In vitro and in vivo characterization of A-940894: a potent histamine H4 receptor antagonist with anti-inflammatory properties.
British journal of pharmacology 2009;157(1):44-54.
2008: Marina I Strakhova; Gerard B Fox; Tracy L Carr; David G Witte; Timothy A Vortherms; Arlene M Manelli; Thomas R Miller; Betty B Yao; Jorge D Brioni; Timothy A Esbenshade
Cloning and characterization of the monkey histamine H3 receptor isoforms.
European journal of pharmacology 2008;601(1-3):8-15.
2008: Robert J Altenbach; Ronald M Adair; Brian M Bettencourt; Lawrence A Black; Shannon R Fix-Stenzel; Sujatha M Gopalakrishnan; Gin C Hsieh; Huaqing Liu; Kennan Marsh; Michael J McPherson; Ivan Milicic; Thomas R Miller; Timothy A Vortherms; Usha Warrior; Jill M Wetter; Neil Wishart; David G Witte; Prisca Honore; Timothy A Esbenshade; Arthur A Hancock; Jorge D Brioni; Marlon D Cowart
Structure-activity studies on a series of a 2-aminopyrimidine-containing histamine H4 receptor ligands.
Journal of medicinal chemistry 2008;51(20):6571-80.
2008: Diana L Nersesian; Lawrence A Black; Thomas R Miller; Timothy A Vortherms; Timothy A Esbenshade; Arthur A Hancock; Marlon D Cowart
In vitro SAR of pyrrolidine-containing histamine H3 receptor antagonists: trends across multiple chemical series.
Bioorganic & medicinal chemistry letters 2008;18(1):355-9.
2007: Timothy A Vortherms; Philip D Mosier; Richard B Westkaemper; Bryan L Roth
Differential helical orientations among related G protein-coupled receptors provide a novel mechanism for selectivity. Studies with salvinorin A and the kappa-opioid receptor.
The Journal of biological chemistry 2007;282(5):3146-56.
2006: Timothy A Vortherms; Bryan L Roth
Salvinorin A: from natural product to human therapeutics.
Molecular interventions 2006;6(5):257-65.
2006: Timothy A Vortherms; Chau H Nguyen; Murat Bastepe; Harald Jüppner; Val Watts
D2 dopamine receptor-induced sensitization of adenylyl cyclase type 1 is G alpha(s) independent.
Neuropharmacology 2006;50(5):576-84.
2005: Thomas Munro; Glenn W Goetchius; Bryan L Roth; Timothy A Vortherms; Mark A Rizzacasa
Autoxidation of salvinorin A under basic conditions.
The Journal of organic chemistry 2005;70(24):10057-61.
2005: Feng Yan; Philip D Mosier; Richard B Westkaemper; Jeremy Stewart; Jordan K Zjawiony; Timothy A Vortherms; Douglas J Sheffler; Bryan L Roth
Identification of the molecular mechanisms by which the diterpenoid salvinorin A binds to kappa-opioid receptors.
Biochemistry 2005;44(24):8643-51.
2005: Timothy A Vortherms; Bryan L Roth
Receptorome screening for CNS drug discovery.
IDrugs : the investigational drugs journal 2005;8(6):491-6.
2005: Matthew S Goldberg; Antonio Pisani; Marian Haburcak; Timothy A Vortherms; Tohru Kitada; Cinzia Costa; Youren Tong; giuseppina martella; Anne Tscherter; Andrea Martins; Giorgio Bernardi; Bryan L Roth; Emmanuel N Pothos; Paolo Calabresi; Jie Shen
Nigrostriatal dopaminergic deficits and hypokinesia caused by inactivation of the familial Parkinsonism-linked gene DJ-1.
Neuron 2005;45(4):489-96.
2004: Timothy A Vortherms; Chau H Nguyen; Catherine H Berlot; Val Watts
Using molecular tools to dissect the role of Galphas in sensitization of AC1.
Molecular pharmacology 2004;66(6):1617-24.
2004: Timothy A Vortherms; Val Watts
Sensitization of neuronal A2A adenosine receptors after persistent D2 dopamine receptor activation.
The Journal of pharmacology and experimental therapeutics 2004;308(1):221-7.
2001: Christopher A Johnston; Medhane G Cumbay; Timothy A Vortherms; Val Watts
Adrenergic agonists induce heterologous sensitization of adenylate cyclase in NS20Y-D(2L) cells.
FEBS letters 2001;497(2-3):85-9.