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Marc Vos

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TOP 3
Kathy C G de Git; Teun P de Boer; Marc A Vos; Michiel van der Heyden
Cardiac ion channel trafficking defects and drugs.
Vincent J A Bourgonje; Nicolas Doisne; Marien Houtman; Lars Kattner; Semir Ozdemir; Erik Rauch; Karin R Sipido; Anita Sztojkov-Ivanov; Roel van der Nagel; Toon A B van Veen; Andras Varro; Marc A Vos; Istvan Zupko; Karoly Acsai; Jet D M Beekman; Virginie Bito; Gudrun Antoons
Combined na+/ca2+ exchanger and L-type calcium channel block as a potential strategy to suppress arrhythmias and maintain ventricular function.
Maartje Noorman; Jeffrey E Saffitz; Michiel van der Heyden; Jasper J van der Smagt; Harold V M van Rijen; Leonie van Stuijvenberg; Andras Varro; Aryan Vink; Marc A Vos; Angeliki Asimaki; Halina Chkourko; Moniek G P J Cox; Jacques M T de Bakker; Nicolaas de Jonge; Roel A de Weger; Mario Delmar; Dennis Dooijes; Judith A Groeneweg; Sara Hakim; Richard N W Hauer; Thomas J Hund; Elise Kessler; Peter J Mohler; Toon A B van Veen
Remodeling of the cardiac sodium channel, connexin43, and plakoglobin at the intercalated disk in patients with arrhythmogenic cardiomyopathy.

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All Publications

2013: Kathy C G de Git; Teun P de Boer; Marc A Vos; Michiel van der Heyden
Cardiac ion channel trafficking defects and drugs.
Pharmacology & therapeutics 2013;139(1):24-31.
2013: Vincent J A Bourgonje; Nicolas Doisne; Marien Houtman; Lars Kattner; Semir Ozdemir; Erik Rauch; Karin R Sipido; Anita Sztojkov-Ivanov; Roel van der Nagel; Toon A B van Veen; Andras Varro; Marc A Vos; Istvan Zupko; Karoly Acsai; Jet D M Beekman; Virginie Bito; Gudrun Antoons
Combined na+/ca2+ exchanger and L-type calcium channel block as a potential strategy to suppress arrhythmias and maintain ventricular function.
Circulation. Arrhythmia and electrophysiology 2013;6(2):371-9.
2013: Maartje Noorman; Jeffrey E Saffitz; Michiel van der Heyden; Jasper J van der Smagt; Harold V M van Rijen; Leonie van Stuijvenberg; Andras Varro; Aryan Vink; Marc A Vos; Angeliki Asimaki; Halina Chkourko; Moniek G P J Cox; Jacques M T de Bakker; Nicolaas de Jonge; Roel A de Weger; Mario Delmar; Dennis Dooijes; Judith A Groeneweg; Sara Hakim; Richard N W Hauer; Thomas J Hund; Elise Kessler; Peter J Mohler; Toon A B van Veen
Remodeling of the cardiac sodium channel, connexin43, and plakoglobin at the intercalated disk in patients with arrhythmogenic cardiomyopathy.
Heart rhythm : the official journal of the Heart Rhythm Society 2013;10(3):412-9.
2013: Rosanne Varkevisser; Marc A Vos; Maaike Waasdorp; Raimond Heukers; Marien J C Houtman; Joyce C K Man; Hiroki Takanari; Ralph G Tieland; Paul M P van Bergen en Henegouwen; Michiel van der Heyden
Inhibiting the clathrin-mediated endocytosis pathway rescues K(IR)2.1 downregulation by pentamidine.
Pflügers Archiv : European journal of physiology 2013;465(2):247-59.
2012: Vincent J A Bourgonje; Leon J De Windt; Marien J C Houtman; Lars F Miedema; Marieke Schoenmakers; Karin R Sipido; Roel van der Nagel; Toon A B van Veen; Gudrun Antoons; Jet D M Beekman; Marc A Vos
Relevance of calmodulin/CaMKII activation for arrhythmogenesis in the AV block dog.
Heart rhythm : the official journal of the Heart Rhythm Society 2012;9(11):1875-83.
2012: Rosanne Varkevisser; Jet D M Beekman; Mathias Meine; Michiel van der Heyden; Sofieke C Wijers; Marc A Vos
Beat-to-beat variability of repolarization as a new biomarker for proarrhythmia in vivo.
Heart rhythm : the official journal of the Heart Rhythm Society 2012;9(10):1718-26.
2012: Malin K B Jonsson; Gary R Mirams; Peter Sartipy; Teun P de Boer; Göran Duker; Marc A Vos; Toon A B van Veen
Application of human stem cell-derived cardiomyocytes in safety pharmacology requires caution beyond hERG.
Journal of molecular and cellular cardiology 2012;52(5):998-1008.
2012: Marc A Vos; Karin R Sipido
Impairment of trafficking by downregulation of an anchor protein: novel insights into additional mechanisms responsible for heart failure.
Heart rhythm : the official journal of the Heart Rhythm Society 2012;9(5):821-2.
2012: Thom R G Stams; Vincent J A Bourgonje; Marc A Vos; Michiel van der Heyden
Verapamil as an antiarrhythmic agent in congestive heart failure: hopping from rabbit to human?
British journal of pharmacology 2012;166(2):554-6.
2012: Sofieke C Wijers; Marc A Vos; Mathias Meine
Microvolt T-wave alternans in an unselected heart failure population: pros and cons.
European journal of heart failure 2012;14(4):344-7.
2012: John A Jansen; Ronald Labzowski; Tri Q Nguyen; Carolin M Oefner; Roel van der Nagel; Astrid A Bosch; Jacques M T de Bakker; Sanne de Jong; Helen Driessen; roel goldschmeding; Leonie van Stuijvenberg; Toon A B van Veen; Marc A Vos; Harold V M van Rijen
Reduced Cx43 expression triggers increased fibrosis due to enhanced fibroblast activity.
Circulation. Arrhythmia and electrophysiology 2012;5(2):380-90.
2012: A Christian Blank; Sara Hakim; Jan L M Strengers; Ronald B Tanke; Toon A van Veen; Marc A Vos; Tim Takken
Exercise capacity in children with isolated congenital complete atrioventricular block: does pacing make a difference?
Pediatric cardiology 2012;33(4):576-85.
2012: John A Jansen; Peter J Mohler; Hassan Musa; Maartje Noorman; Mèra Stein; Roel van der Nagel; Jacques M T de Bakker; Sanne de Jong; Mario Delmar; Thomas J Hund; Toon A van Veen; Marc A Vos; Harold V M van Rijen
Reduced heterogeneous expression of Cx43 results in decreased Nav1.5 expression and reduced sodium current that accounts for arrhythmia vulnerability in conditional Cx43 knockout mice.
Heart rhythm : the official journal of the Heart Rhythm Society 2012;9(4):600-7.
2012: Albert Dunnink; Peter Oosterhoff; Roel van der Nagel; Jurren M van Opstal; Jet D M Beekman; S Cora Verduyn; Stephan K G Winckels; Marc A Vos
Ventricular remodelling is a prerequisite for the induction of dofetilide-induced torsade de pointes arrhythmias in the anaesthetized, complete atrio-ventricular-block dog.
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 2012;14(3):431-6.
2012: Thin-Thin Aye; Salvatore Cappadona; Nicolaas de Jonge; Roel A de Weger; Albert J R Heck; Siddarth Soni; Michiel van der Heyden; Toon A B van Veen; Andras Varro; Marc A Vos; Arjen Scholten
Reorganized PKA-AKAP associations in the failing human heart.
Journal of molecular and cellular cardiology 2012;52(2):511-8.
2012: Marien J C Houtman; Bart G J M Kok; Denise R Montagne; Hiroki Takanari; Margot van Eck; Marc A Vos; Teun P de Boer; Michiel van der Heyden
Experimental Mapping of the Canine KCNJ2 and KCNJ12 Gene Structures and Functional Analysis of the Canine K(IR)2.2 ion Channel.
Frontiers in physiology 2012;3():9.
2011: Thom R G Stams; Jet D M Beekman; Paul Chamberlin; Roel van der Nagel; Howard C Dittrich; Avram Oros; Marc A Vos
Effects of K201 on repolarization and arrhythmogenesis in anesthetized chronic atrioventricular block dogs susceptible to dofetilide-induced torsade de pointes.
European journal of pharmacology 2011;672(1-3):126-34.
2011: Sanne de Jong; Roel van der Nagel; Jacques M de Bakker; Harold V M van Rijen; Fredy Visser; Marc A Vos; Jaco J Zwanenburg; Peter R Luijten
Direct detection of myocardial fibrosis by MRI.
Journal of molecular and cellular cardiology 2011;51(6):974-9.
2011: Peter Oosterhoff; Larisa Tereshchenko; Michiel van der Heyden; Ronald D Berger; Barry J Fetics; Raja N Ghanem; Marc A Vos
Short-term variability of repolarization predicts ventricular tachycardia and sudden cardiac death in patients with structural heart disease: a comparison with QT variability index.
Heart rhythm : the official journal of the Heart Rhythm Society 2011;8(10):1584-90.
2011: Mohamed Boulaksil; Jacques M T de Bakker; Teun P de Boer; Marien J C Houtman; Jerome G Jungschleger; Jos G Maessen; Michiel van der Heyden; Ferenc F van der Hulst; Harold V M van Rijen; Toon A B van Veen; Gudrun Antoons; Jet D M Beekman; Ronald Wilders; Marc A Vos
Drug-induced torsade de pointes arrhythmias in the chronic AV block dog are perpetuated by focal activity.
Circulation. Arrhythmia and electrophysiology 2011;4(4):566-76.
2011: Vincent Floré; Patricia Holemans; Peter Oosterhoff; Karin R Sipido; Marc A Vos; Gudrun Antoons; Piet Claus; Rik Willems
Microvolt T-wave alternans and beat-to-beat variability of repolarization during early postischemic remodeling in a pig heart.
Heart rhythm : the official journal of the Heart Rhythm Society 2011;8(7):1050-7.
2011: Sanne de Jong; Toon A B van Veen; Jacques M T de Bakker; Marc A Vos; Harold V M van Rijen
Biomarkers of myocardial fibrosis.
Journal of cardiovascular pharmacology 2011;57(5):522-35.
2011: Lukas Nalos; Teun P de Boer; Marien J C Houtman; Martin B Rook; Marc A Vos; Michiel van der Heyden
Inhibition of lysosomal degradation rescues pentamidine-mediated decreases of K(IR)2.1 ion channel expression but not that of K(v)11.1.
European journal of pharmacology 2011;652(1-3):96-103.
2010: Peter Oosterhoff; Morten B Thomsen; Joep N Maas; Nico J M Atteveld; Jet D M Beekman; Harold V M van Rijen; Michiel van der Heyden; Marc A Vos
High-rate pacing reduces variability of repolarization and prevents repolarization-dependent arrhythmias in dogs with chronic AV block.
Journal of cardiovascular electrophysiology 2010;21(12):1384-91.
2010: M Boulaksil; M Noorman; M A Engelen; Toon A B van Veen; Marc A Vos; J M T de Bakker; Harold V M van Rijen
Longitudinal arrhythmogenic remodelling in a mouse model of longstanding pressure overload.
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation 2010;18(10):509-15.
2010: Leonie van Stuijvenberg; Cansu Yildirim; Bart G J M Kok; Toon A B van Veen; András Varró; Stephan K G Winckels; Marc A Vos; Marti F A Bierhuizen
Alternative promoter usage and splicing of the human SCN5A gene contribute to transcript heterogeneity.
DNA and cell biology 2010;29(10):577-87.
2010: Thin Thin Aye; Arjen Scholten; Nadia Taouatas; Andras Varro; Toon A B van Veen; Marc A Vos; Albert J R Heck
Proteome-wide protein concentrations in the human heart.
Molecular bioSystems 2010;6(10):1917-27.
2010: Avram Oros; M J Houtman; P Neco; Ana Gomez; S Rajamani; P Oosterhoff; N J Attevelt; Jet D M Beekman; Michiel van der Heyden; L Ver Donck; L Belardinelli; S Richard; Gudrun Antoons; Marc A Vos
Robust anti-arrhythmic efficacy of verapamil and flunarizine against dofetilide-induced TdP arrhythmias is based upon a shared and a different mode of action.
British journal of pharmacology 2010;161(1):162-75.
2010: Mohamed Boulaksil; Stephan K G Winckels; Markus A Engelen; Mèra Stein; Toon A B van Veen; John A Jansen; André C Linnenbank; Marti F A Bierhuizen; W Antoinette Groenewegen; Matthijs F M van Oosterhout; Johannes H Kirkels; Nicolaas de Jonge; András Varró; Marc A Vos; Jacques M T de Bakker; Harold V M van Rijen
Heterogeneous Connexin43 distribution in heart failure is associated with dispersed conduction and enhanced susceptibility to ventricular arrhythmias.
European journal of heart failure 2010;12(9):913-21.
2010: Martin Hinterseer; britt beckmann; Morten B Thomsen; Arne Pfeufer; Michael Ulbrich; Moritz F Sinner; Siegfried Perz; H-Erich Wichmann; Csaba Lengyel; Rainer Schimpf; Sebastian K G Maier; András Varró; Marc A Vos; Gerhard Steinbeck; Stefan Kääb
Usefulness of short-term variability of QT intervals as a predictor for electrical remodeling and proarrhythmia in patients with nonischemic heart failure.
The American journal of cardiology 2010;106(2):216-20.
2010: Marc A Vos
The quest for an anti-arrhythmic drug against atrial fibrillation that combines efficacy with safety.
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 2010;12(7):925-6.
2010: Malin Jonsson; Marc A Vos; G Duker; Sophie Demolombe; T A B van Veen
Gender disparity in cardiac electrophysiology: implications for cardiac safety pharmacology.
Pharmacology & therapeutics 2010;127(1):9-18.
2010: Marti F A Bierhuizen; Marc A Vos
The molecular labyrinth of electrical remodeling: making sense of cardiac memory.
Heart rhythm : the official journal of the Heart Rhythm Society 2010;7(7):971-2.
2010: Malin Jonsson; Göran Duker; Charlotte Tropp; Birgit Andersson; Peter Sartipy; Marc A Vos; Toon A B van Veen
Quantified proarrhythmic potential of selected human embryonic stem cell-derived cardiomyocytes.
Stem cell research 2010;4(3):189-200.
2010: T P de Boer; L Nalos; A Stary; B Kok; M J C Houtman; Gudrun Antoons; T A B van Veen; Jet D M Beekman; B L de Groot; T Opthof; M B Rook; Marc A Vos; Michiel van der Heyden
The anti-protozoal drug pentamidine blocks KIR2.x-mediated inward rectifier current by entering the cytoplasmic pore region of the channel.
British journal of pharmacology 2010;159(7):1532-41.
2010: Gudrun Antoons; Avram Oros; Jet D M Beekman; Markus A Engelen; Marien J C Houtman; Luiz Belardinelli; Milan Stengl; Marc A Vos
Late na(+) current inhibition by ranolazine reduces torsades de pointes in the chronic atrioventricular block dog model.
Journal of the American College of Cardiology 2010;55(8):801-9.
2009: Maurits C E F Wijffels; Matthijs Van Oosterhout; Lucas V A Boersma; Randy Werneth; Chris Kunis; Betty Hu; Jet D M Beekman; Marc A Vos
Characterization of in vitro and in vivo lesions made by a novel multichannel ablation generator and a circumlinear decapolar ablation catheter.
Journal of cardiovascular electrophysiology 2009;20(10):1142-8.
2009: Marc A Vos
Enhanced efficacy with MgSO4 due to an additive, alternative, or dual mode of action?
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 2009;11(7):844-5.
2009: Martin Hinterseer; britt beckmann; Morten B Thomsen; Arne Pfeufer; Robert Dalla Pozza; Markus Loeff; Heinrich Netz; Gerhard Steinbeck; Marc A Vos; Stefan Kääb
Relation of increased short-term variability of QT interval to congenital long-QT syndrome.
The American journal of cardiology 2009;103(9):1244-8.
2009: Malin Kb Jonsson; Göran Duker; Marie-Jose Goumans; Toon Ab van Veen; Marc A Vos; Peter Sartipy
Improvement of cardiac efficacy and safety models in drug discovery by the use of stem cell-derived cardiomyocytes.
Expert opinion on drug discovery 2009;4(4):357-72.
2008: Marti F A Bierhuizen; Mohamed Boulaksil; Leonie van Stuijvenberg; Roel van der Nagel; Anita T Jansen; Nancy A M Mutsaers; Cansu Yildirim; Toon A B van Veen; Leon J De Windt; Marc A Vos; Harold V M van Rijen
In calcineurin-induced cardiac hypertrophy expression of Nav1.5, Cx40 and Cx43 is reduced by different mechanisms.
Journal of molecular and cellular cardiology 2008;45(3):373-84.
2008: Marc A Vos
Literature-based evaluation of four 'hard endpoint' models for assessing drug-induced torsades de pointes liability.
British journal of pharmacology 2008;154(7):1523-7.
2008: Avram Oros; Jet D M Beekman; Marc A Vos
The canine model with chronic, complete atrio-ventricular block.
Pharmacology & therapeutics 2008;119(2):168-78.
2008: John A Jansen; Teun de Boer; Rianne Wolswinkel; Toon A B van Veen; Marc A Vos; Harold V M van Rijen; Michiel van der Heyden
Lysosome mediated Kir2.1 breakdown directly influences inward rectifier current density.
Biochemical and biophysical research communications 2008;367(3):687-92.
2008: Michiel van der Heyden; M E Smits; Marc A Vos
Drugs and trafficking of ion channels: a new pro-arrhythmic threat on the horizon?
British journal of pharmacology 2008;153(3):406-9.
2008: Martin Hinterseer; Morten B Thomsen; britt beckmann; Arne Pfeufer; Rainer Schimpf; H-Erich Wichmann; Gerhard Steinbeck; Marc A Vos; Stefan Kaab
Beat-to-beat variability of QT intervals is increased in patients with drug-induced long-QT syndrome: a case control pilot study.
European heart journal 2008;29(2):185-90.
2007: Gudrun Antoons; Avram Oros; Virginie Bito; Karin R Sipido; Marc A Vos
Cellular basis for triggered ventricular arrhythmias that occur in the setting of compensated hypertrophy and heart failure: considerations for diagnosis and treatment.
Journal of electrocardiology 2007;40(6 Suppl):S8-14.
2007: Dirk W Donker; Jos G Maessen; Roel L H M G Spätjens; Theo Van Der Nagel; Monique de Jong; Frans C Ramaekers; Harry J G M Crijns; Marc A Vos; Paul G A Volders
Serial left-ventricular biopsy sampling using a minimally invasive trans-thoracic approach in adult dogs.
Pflügers Archiv : European journal of physiology 2007;454(6):1043-51.
2007: Stephan K G Winckels; Morten B Thomsen; Peter Oosterhoff; Avram Oros; Jet D M Beekman; Nico J M Attevelt; Leo Kretzers; Marc A Vos
High-septal pacing reduces ventricular electrical remodeling and proarrhythmia in chronic atrioventricular block dogs.
Journal of the American College of Cardiology 2007;50(9):906-13.
2007: Peter Oosterhoff; Avram Oros; Marc A Vos
Beat-to-beat variability of repolarization: a new parameter to determine arrhythmic risk of an individual or identify proarrhythmic drugs.
Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology 2007;7 Suppl 1():73-8.
2007: Teun de Boer; Harold V M van Rijen; Michiel van der Heyden; Bart Kok; Tobias Opthof; Marc A Vos; Habo J Jongsma; Jacques M T de Bakker; Toon A B van Veen
Beta-, not alpha-adrenergic stimulation enhances conduction velocity in cultures of neonatal cardiomyocytes.
Circulation journal : official journal of the Japanese Circulation Society 2007;71(6):973-81.
2007: Arjen Scholten; Toon A B van Veen; Marc A Vos; albert heck
Diversity of cAMP-dependent protein kinase isoforms and their anchoring proteins in mouse ventricular tissue.
Journal of proteome research 2007;6(5):1705-17.
2007: Dirk W Donker; Jos G Maessen; Fons Verheyen; Frans C Ramaekers; Roel L H M G Spätjens; Helma Kuijpers; Christian Ramakers; Paul M H Schiffers; Marc A Vos; Harry J G M Crijns; Paul G A Volders
Impact of acute and enduring volume overload on mechanotransduction and cytoskeletal integrity of canine left ventricular myocardium.
American journal of physiology. Heart and circulatory physiology 2007;292(5):H2324-32.
2007: Karin R Sipido; Virginie Bito; Gudrun Antoons; Paul G A Volders; Marc A Vos
Na/Ca exchange and cardiac ventricular arrhythmias.
Annals of the New York Academy of Sciences 2007;1099():339-48.
2007: Teun de Boer; Toon A B van Veen; Marti F A Bierhuizen; Bart Kok; Martin B Rook; Kristel J M Boonen; Marc A Vos; Pieter A Doevendans; Jacques M T de Bakker; Michiel van der Heyden
Connexin43 repression following epithelium-to-mesenchyme transition in embryonal carcinoma cells requires Snail1 transcription factor.
Differentiation; research in biological diversity 2007;75(3):208-18.
2007: Gudrun Antoons; Paul G A Volders; Tania Stankovicova; Virginie Bito; Milan Stengl; Marc A Vos; Karin R Sipido
Window Ca2+ current and its modulation by Ca2+ release in hypertrophied cardiac myocytes from dogs with chronic atrioventricular block.
The Journal of physiology 2007;579(Pt 1):147-60.
2007: Birgit E J Teunissen; Anita T Jansen; Nancy A M Mutsaers; Maria J Vuerhard; Marc A Vos; Marti F A Bierhuizen
Primary structure, organization, and expression of the rat connexin45 gene.
DNA and cell biology 2007;26(2):108-15.
2007: Morten B Thomsen; Avram Oros; Marieke Schoenmakers; Jurren M van Opstal; Joep N Maas; Jet D M Beekman; Marc A Vos
Proarrhythmic electrical remodelling is associated with increased beat-to-beat variability of repolarisation.
Cardiovascular research 2007;73(3):521-30.
2006: Morten B Thomsen; Jet D M Beekman; Nico J M Attevelt; A Takahara; A Sugiyama; K Chiba; Marc A Vos
No proarrhythmic properties of the antibiotics Moxifloxacin or Azithromycin in anaesthetized dogs with chronic-AV block.
British journal of pharmacology 2006;149(8):1039-48.
2006: Avram Oros; Paul G A Volders; Jet D M Beekman; Theo Van Der Nagel; Marc A Vos
Atrial-specific drug AVE0118 is free of torsades de pointes in anesthetized dogs with chronic complete atrioventricular block.
Heart rhythm : the official journal of the Heart Rhythm Society 2006;3(11):1339-45.
2006: Teun de Boer; Bart Kok; Giulietta Roël; Toon A B van Veen; Olivier Destrée; Martin B Rook; Marc A Vos; Jacques M T de Bakker; Michiel van der Heyden
Cloning, embryonic expression, and functional characterization of two novel connexins from Xenopus laevis.
Biochemical and biophysical research communications 2006;349(2):855-62.
2006: Milan Stengl; Christian Ramakers; Dirk W Donker; Ashish Nabar; Andrew V Rybin; Roel L H M G Spätjens; Theo Van Der Nagel; Will K W H Wodzig; Karin R Sipido; Gudrun Antoons; Antoon F M Moorman; Marc A Vos; Paul G A Volders
Temporal patterns of electrical remodeling in canine ventricular hypertrophy: focus on IKs downregulation and blunted beta-adrenergic activation.
Cardiovascular research 2006;72(1):90-100.
2006: Morten B Thomsen; Jørgen Matz; Paul G A Volders; Marc A Vos
Assessing the proarrhythmic potential of drugs: current status of models and surrogate parameters of torsades de pointes arrhythmias.
Pharmacology & therapeutics 2006;112(1):150-70.
2006: Morten B Thomsen; Paul G A Volders; Jet D M Beekman; Jørgen Matz; Marc A Vos
Beat-to-Beat variability of repolarization determines proarrhythmic outcome in dogs susceptible to drug-induced torsades de pointes.
Journal of the American College of Cardiology 2006;48(6):1268-76.
2006: Teun de Boer; Michiel van der Heyden; Martin B Rook; Ronald Wilders; Renske Broekstra; Bart Kok; Marc A Vos; Jacques M T de Bakker; Toon A B van Veen
Pro-arrhythmogenic potential of immature cardiomyocytes is triggered by low coupling and cluster size.
Cardiovascular research 2006;71(4):704-14.
2006: Teun de Boer; Toon A B van Veen; Marien J C Houtman; John A Jansen; Shirley C M van Amersfoorth; Pieter A Doevendans; Marc A Vos; Michiel van der Heyden
Inhibition of cardiomyocyte automaticity by electrotonic application of inward rectifier current from Kir2.1 expressing cells.
Medical & biological engineering & computing 2006;44(7):537-42.
2006: Arjen Scholten; Mee Kian Poh; Toon A B van Veen; Bas van Breukelen; Marc A Vos; albert heck
Analysis of the cGMP/cAMP interactome using a chemical proteomics approach in mammalian heart tissue validates sphingosine kinase type 1-interacting protein as a genuine and highly abundant AKAP.
Journal of proteome research 2006;5(6):1435-47.
2005: Toon A B van Veen; Harold V M van Rijen; Marjan J A van Kempen; Lucile Miquerol; Tobias Opthof; Daniel Gros; Marc A Vos; Habo J Jongsma; Jacques M T de Bakker
Discontinuous conduction in mouse bundle branches is caused by bundle-branch architecture.
Circulation 2005;112(15):2235-44.
2005: Teun de Boer; Bart Kok; Kirsten I E Neuteboom; Nicole Spieker; Jochum De Graaf; Olivier Destrée; Martin B Rook; Toon A B van Veen; Habo J Jongsma; Marc A Vos; Jacques M T de Bakker; Michiel van der Heyden
Cloning and functional characterization of a novel connexin expressed in somites of Xenopus laevis.
Developmental dynamics : an official publication of the American Association of Anatomists 2005;233(3):864-71.
2005: Dirk W Donker; Paul G A Volders; T Arts; B C A M Bekkers; Leo Hofstra; Roel L H M G Spätjens; Jet D M Beekman; M Borgers; Harry J G M Crijns; Marc A Vos
End-diastolic myofiber stress and ejection strain increase with ventricular volume overload--Serial in-vivo analyses in dogs with complete atrioventricular block.
Basic research in cardiology 2005;100(4):372-82.
2005: Elke Detre; Morten B Thomsen; Jet D M Beekman; Karl-Uwe Petersen; Marc A Vos
Decreasing the infusion rate reduces the proarrhythmic risk of NS-7: confirming the relevance of short-term variability of repolarisation in predicting drug-induced torsades de pointes.
British journal of pharmacology 2005;145(3):397-404.
2005: Morten B Thomsen; Michiel Truin; Jurren M van Opstal; Jet D M Beekman; Paul G A Volders; Milan Stengl; Marc A Vos
Sudden cardiac death in dogs with remodeled hearts is associated with larger beat-to-beat variability of repolarization.
Basic research in cardiology 2005;100(3):279-87.
2005: Christian Ramakers; Milan Stengl; Roel L H M G Spätjens; Antoon F M Moorman; Marc A Vos
Molecular and electrical characterization of the canine cardiac ventricular septum.
Journal of molecular and cellular cardiology 2005;38(1):153-61.
2004: Morten B Thomsen; S Cora Verduyn; Milan Stengl; Jet D M Beekman; Geert de Pater; Jurren M van Opstal; Paul G A Volders; Marc A Vos
Increased short-term variability of repolarization predicts d-sotalol-induced torsades de pointes in dogs.
Circulation 2004;110(16):2453-9.
2004: S Cora Verduyn; Jérôme G M Jungschleger; Milan Stengl; Roel L H M G Spätjens; Jet D M Beekman; Marc A Vos
Electrophysiological and proarrhythmic parameters in transmural canine left-ventricular needle biopsies.
Pflügers Archiv : European journal of physiology 2004;449(1):115-22.
2004: Marc A Vos; Aimée D C Paulussen
Genetic basis of drug-induced arrhythmias.
Annals of medicine 2004;36 Suppl 1():35-40.
2003: Morten B Thomsen; Paul G A Volders; Milan Stengl; Roel L H M G Spätjens; Jet D M Beekman; Ulrike Bischoff; Morten A Kall; Kristen Frederiksen; Jørgen Matz; Marc A Vos
Electrophysiological safety of sertindole in dogs with normal and remodeled hearts.
The Journal of pharmacology and experimental therapeutics 2003;307(2):776-84.
2003: Milan Stengl; Paul G A Volders; Morten B Thomsen; Roel L H M G Spätjens; Karin R Sipido; Marc A Vos
Accumulation of slowly activating delayed rectifier potassium current (IKs) in canine ventricular myocytes.
The Journal of physiology 2003;551(Pt 3):777-86.
2003: Marieke Schoenmakers; Christian Ramakers; Jurren M van Opstal; Jet D M Leunissen; Camila Londoño; Marc A Vos
Asynchronous development of electrical remodeling and cardiac hypertrophy in the complete AV block dog.
Cardiovascular research 2003;59(2):351-9.
2003: Paul G A Volders; Milan Stengl; Jurren M van Opstal; Uwe Gerlach; Roel L H M G Spätjens; Jet D M Beekman; Karin R Sipido; Marc A Vos
Probing the contribution of IKs to canine ventricular repolarization: key role for beta-adrenergic receptor stimulation.
Circulation 2003;107(21):2753-60.
2003: Maaike Peschar; Kevin Vernooy; Ward Y Vanagt; Robert S Reneman; Marc A Vos; Frits W Prinzen
Absence of reverse electrical remodeling during regression of volume overload hypertrophy in canine ventricles.
Cardiovascular research 2003;58(3):510-7.
2003: Xander H T Wehrens; Tom Rossenbacker; Roselie J Jongbloed; Marc Gewillig; Hein Heidbüchel; Pieter A Doevendans; Marc A Vos; Hein J J Wellens; Robert Kass
A novel mutation L619F in the cardiac Na+ channel SCN5A associated with long-QT syndrome (LQT3): a role for the I-II linker in inactivation gating.
Human mutation 2003;21(5):552.
2003: Fons Verdonck; Paul G A Volders; Marc A Vos; Karin R Sipido
Increased Na+ concentration and altered Na/K pump activity in hypertrophied canine ventricular cells.
Cardiovascular research 2003;57(4):1035-43.
2003: Christian Ramakers; Marc A Vos; P A Doevendans; Marieke Schoenmakers; Y S Wu; S Scicchitano; A Iodice; G P Thomas; Charles Antzelevitch; R Dumaine
Coordinated down-regulation of KCNQ1 and KCNE1 expression contributes to reduction of I(Ks) in canine hypertrophied hearts.
Cardiovascular research 2003;57(2):486-96.
2003: Fons Verdonck; Paul G A Volders; Marc A Vos; Karin R Sipido
Intracellular Na+ and altered Na+ transport mechanisms in cardiac hypertrophy and failure.
Journal of molecular and cellular cardiology 2003;35(1):5-25.
2002: Karin R Sipido; Paul G A Volders; Marieke Schoenmakers; S H Marieke De Groot; Fons Verdonck; Marc A Vos
Role of the Na/Ca exchanger in arrhythmias in compensated hypertrophy.
Annals of the New York Academy of Sciences 2002;976():438-45.
2002: Jurren M van Opstal; S Cora Verduyn; Stephan K G Winckels; Hendrik M Leerssen; Jet D M Leunissen; Hein J J Wellens; Marc A Vos
The JT-area indicates dispersion of repolarization in dogs with atrioventricular block.
Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing 2002;6(2):113-20.
2002: Karin R Sipido; Paul G A Volders; Marc A Vos; Fons Verdonck
Altered Na/Ca exchange activity in cardiac hypertrophy and heart failure: a new target for therapy?
Cardiovascular research 2002;53(4):782-805.
2001: Jurren M van Opstal; Marieke Schoenmakers; S Cora Verduyn; S H Marieke De Groot; Jet D M Leunissen; FF van der Hulst; M M Molenschot; Hein J J Wellens; Marc A Vos
Chronic amiodarone evokes no torsade de pointes arrhythmias despite QT lengthening in an animal model of acquired long-QT syndrome.
Circulation 2001;104(22):2722-7.
2001: Marc A Vos; Jurren M van Opstal; Jet D M Leunissen; S Cora Verduyn
Electrophysiologic parameters and predisposing factors in the generation of drug-induced Torsade de Pointes arrhythmias.
Pharmacology & therapeutics 2001;92(2-3):109-22.
2001: Dieter Nuyens; Milan Stengl; S Dugarmaa; Tom Rossenbacker; Veerle Compernolle; Yoram Rudy; Jos F M Smits; Willem Flameng; colleen clancy; Lieve Moons; Marc A Vos; Mieke Dewerchin; Klaus Benndorf; Désiré Collen; Edward Carmeliet; Peter Carmeliet
Abrupt rate accelerations or premature beats cause life-threatening arrhythmias in mice with long-QT3 syndrome.
Nature medicine 2001;7(9):1021-7.
2001: Marc A Vos; Jérôme G M Jungschleger
Transmural repolarization gradients in vivo: the flukes and falls of the endocardium.
Cardiovascular research 2001;50(3):423-5.
2001: S Cora Verduyn; Christian Ramakers; G Snoep; Jet D M Leunissen; Hein J J Wellens; Marc A Vos
Time course of structural adaptations in chronic AV block dogs: evidence for differential ventricular remodeling.
American journal of physiology. Heart and circulatory physiology 2001;280(6):H2882-90.
2001: Jurren M van Opstal; S Cora Verduyn; HD Leunissen; S H Marieke De Groot; Hein J J Wellens; Marc A Vos
Electrophysiological parameters indicative of sudden cardiac death in the dog with chronic complete AV-block.
Cardiovascular research 2001;50(2):354-61.
2001: Marc A Vos; Harry J G M Crijns
Myocardial repolarization and drugs. Impossibility to predict the dominance of anti-arrhythmic over pro-arrhythmic effects of drugs due to differential and ventricular electrical remodeling.
Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology 2001;1(1):27-34.
2001: Jurren M van Opstal; Jet D M Leunissen; Hein J J Wellens; Marc A Vos
Azimilide and dofetilide produce similar electrophysiological and proarrhythmic effects in a canine model of Torsade de Pointes arrhythmias.
European journal of pharmacology 2001;412(1):67-76.
2001: S Cora Verduyn; Jurren M van Opstal; Jet D M Leunissen; Marc A Vos
Assessment of the pro-arrhythmic potential of anti-arrhythmic drugs: an experimental approach.
Journal of cardiovascular pharmacology and therapeutics 2001;6(1):89-97.
2000: Marc A Vos; B Gorenek; S Cora Verduyn; FF van der Hulst; Jet D M Leunissen; L Dohmen; Hein J J Wellens
Observations on the onset of torsade de pointes arrhythmias in the acquired long QT syndrome.
Cardiovascular research 2000;48(3):421-9.
2000: L van der Zee; MC Wijffels; C van Leuven; R Dorland; Marc A Vos; Habo J Jongsma; Maurits A Allessie
Atrial fibrillation in the goat induces changes in monophasic action potential and mRNA expression of ion channels involved in repolarization.
Journal of cardiovascular electrophysiology 2000;11(11):1262-9.
2000: S H Marieke De Groot; Marieke Schoenmakers; M M Molenschot; Jet D M Leunissen; Hein J J Wellens; Marc A Vos
Contractile adaptations preserving cardiac output predispose the hypertrophied canine heart to delayed afterdepolarization-dependent ventricular arrhythmias.
Circulation 2000;102(17):2145-51.
2000: Karin R Sipido; Paul G A Volders; S H Marieke De Groot; Fons Verdonck; Frans Van de Werf; Hein J J Wellens; Marc A Vos
Enhanced Ca(2+) release and Na/Ca exchange activity in hypertrophied canine ventricular myocytes: potential link between contractile adaptation and arrhythmogenesis.
Circulation 2000;102(17):2137-44.
2000: Jérôme G M Jungschleger; Marc A Vos
Hybrid action potential etiology.
Journal of cardiovascular electrophysiology 2000;11(8):946-8; author reply 948-51.
2000: Paul G A Volders; Marc A Vos; B Szabo; Karin R Sipido; S H Marieke De Groot; Anton P Gorgels; Hein J J Wellens; R Lazzara
Progress in the understanding of cardiac early afterdepolarizations and torsades de pointes: time to revise current concepts.
Cardiovascular research 2000;46(3):376-92.
2000: Hendrik M Leerssen; Marc A Vos; Ruud Houben; K den Dulk; Hein J J Wellens
High uniformity of left and right ventricular repolarization dynamics induced by an abrupt decrease in pacing cycle length in a dog is not affected by left ventricular ischemia.
Journal of cardiovascular electrophysiology 2000;11(4):421-9.
1999: Paul G A Volders; Karin R Sipido; Marc A Vos; Roel L H M G Spätjens; Jet D M Leunissen; Edward Carmeliet; Hein J J Wellens
Downregulation of delayed rectifier K(+) currents in dogs with chronic complete atrioventricular block and acquired torsades de pointes.
Circulation 1999;100(24):2455-61.
1999: Hendrik M Leerssen; Marc A Vos; K den Dulk; J van der Zande; Hein J J Wellens
Rate dependent effects of procainamide on the threshold current for pacing in the setting of postrepolarization refractoriness in dogs.
Pacing and clinical electrophysiology : PACE 1999;22(2):291-301.
1999: S Cora Verduyn; Marc A Vos; HD Leunissen; Jurren M van Opstal; Hein J J Wellens
Evaluation of the acute electrophysiologic effects of intravenous dronedarone, an amiodarone-like agent, with special emphasis on ventricular repolarization and acquired torsade de pointes arrhythmias.
Journal of cardiovascular pharmacology 1999;33(2):212-22.
1999: Paul G A Volders; Karin R Sipido; Edward Carmeliet; Roel L H M G Spätjens; Hein J J Wellens; Marc A Vos
Repolarizing K+ currents ITO1 and IKs are larger in right than left canine ventricular midmyocardium.
Circulation 1999;99(2):206-10.
1999: S H Marieke De Groot; Marc A Vos; Anton P Gorgels; Jet D M Leunissen; M Hermans; L R Dohmen; Hein J J Wellens
The dynamic behavior of the diastolic slope of monophasic action potential can be related to the occurrence and maintenance of delayed afterdepolarization dependent arrhythmias.
Pacing and clinical electrophysiology : PACE 1999;22(1 Pt 1):49-59.
1998: Paul G A Volders; Karin R Sipido; Marc A Vos; A Kulcsár; S Cora Verduyn; Hein J J Wellens
Cellular basis of biventricular hypertrophy and arrhythmogenesis in dogs with chronic complete atrioventricular block and acquired torsade de pointes.
Circulation 1998;98(11):1136-47.
1998: Marc A Vos; S H Marieke De Groot; S Cora Verduyn; J van der Zande; HD Leunissen; Jack P M Cleutjens; Marc van Bilsen; M J Daemen; Jan J Schreuder; M A Allessie; Hein J J Wellens
Enhanced susceptibility for acquired torsade de pointes arrhythmias in the dog with chronic, complete AV block is related to cardiac hypertrophy and electrical remodeling.
Circulation 1998;98(11):1125-35.
1998: Hendrik M Leerssen; Marc A Vos; K den Dulk; J van der Zande; Arno M M Muijtjens; M J Begemann; Hein J J Wellens
Steady-state and dynamic behavior of ventricular repolarization and refractoriness in the dog: the effect of multiple cycle length changes and d-sotalol administration.
Pacing and clinical electrophysiology : PACE 1998;21(9):1766-77.
1998: Marc A Vos; S R Golitsyn; K Stangl; M Y Ruda; L V Van Wijk; J D Harry; K T Perry; P Touboul; G Steinbeck; Hein J J Wellens
Superiority of ibutilide (a new class III agent) over DL-sotalol in converting atrial flutter and atrial fibrillation. The Ibutilide/Sotalol Comparator Study Group.
Heart (British Cardiac Society) 1998;79(6):568-75.
1997: S Cora Verduyn; Marc A Vos; J van der Zande; A Kulcsàr; Hein J J Wellens
Further observations to elucidate the role of interventricular dispersion of repolarization and early afterdepolarizations in the genesis of acquired torsade de pointes arrhythmias: a comparison between almokalant and d-sotalol using the dog as its own control.
Journal of the American College of Cardiology 1997;30(6):1575-84.
1997: S Cora Verduyn; Marc A Vos; J van der Zande; FF van der Hulst; Hein J J Wellens
Role of interventricular dispersion of repolarization in acquired torsade-de-pointes arrhythmias: reversal by magnesium.
Cardiovascular research 1997;34(3):453-63.
1997: Paul G A Volders; A Kulcśar; Marc A Vos; Karin R Sipido; H J Wellens; Ralph Lazzara; B Szabo
Similarities between early and delayed afterdepolarizations induced by isoproterenol in canine ventricular myocytes.
Cardiovascular research 1997;34(2):348-59.
1996: Anton P Gorgels; A van den Dool; A Hofs; R Mulleneers; Joep L R M Smeets; Marc A Vos; Hein J J Wellens
Comparison of procainamide and lidocaine in terminating sustained monomorphic ventricular tachycardia.
The American journal of cardiology 1996;78(1):43-6.
1995: S H Marieke De Groot; Marc A Vos; Anton P Gorgels; Jet D M Leunissen; B J van der Steld; Hein J J Wellens
Combining monophasic action potential recordings with pacing to demonstrate delayed afterdepolarizations and triggered arrhythmias in the intact heart. Value of diastolic slope.
Circulation 1995;92(9):2697-704.
1995: S Cora Verduyn; Marc A Vos; Anton P Gorgels; J van der Zande; Jet D M Leunissen; Hein J J Wellens
The effect of flunarizine and ryanodine on acquired torsades de pointes arrhythmias in the intact canine heart.
Journal of cardiovascular electrophysiology 1995;6(3):189-200.
1995: Marc A Vos; S Cora Verduyn; Anton P Gorgels; G C Lipcsei; Hein J J Wellens
Reproducible induction of early afterdepolarizations and torsade de pointes arrhythmias by d-sotalol and pacing in dogs with chronic atrioventricular block.
Circulation 1995;91(3):864-72.
1994: Hendrik M Leerssen; Marc A Vos; K den Dulk; J van der Zande; Hein J J Wellens
Is the ventricular effective refractory period different when determined by incremental versus decremental scanning?: the effect of pacing cycle length, d-sotalol, and levcromakalim.
Pacing and clinical electrophysiology : PACE 1994;17(11 Pt 2):2084-9.
1994: Hendrik M Leerssen; Marc A Vos; K den Dulk; J van der Zande; M J Begemann; Hein J J Wellens
Inter- and intraindividual variations in shortening of ventricular effective refractory period after an abrupt decrease in pacing cycle length.
Pacing and clinical electrophysiology : PACE 1994;17(11 Pt 2):2079-83.
1994: Marc A Vos; Anton P Gorgels; G C Lipcsei; S H Marieke De Groot; Jet D M Leunissen; Hein J J Wellens
Mechanism-specific antiarrhythmic effects of the potassium channel activator levcromakalim against repolarization-dependent tachycardias.
Journal of cardiovascular electrophysiology 1994;5(9):731-42.
1994: Marc A Vos; T Fazekas; Anton P Gorgels; Jet D M Leunissen; Hein J J Wellens
Action of MgSO4 differs from moricizine and verapamil on ouabain-induced ventricular tachycardia in normomagnesemic conscious dogs.
Journal of cardiovascular pharmacology 1994;23(2):252-8.
1993: Anton P Gorgels; Marc A Vos; R Mulleneers; Chris de Zwaan; Frits W H M Bär; Hein J J Wellens
Value of the electrocardiogram in diagnosing the number of severely narrowed coronary arteries in rest angina pectoris.
The American journal of cardiology 1993;72(14):999-1003.
1993: Marc A Vos; R T van Deursen; Anton P Gorgels; Jet D M Leunissen; Hein J J Wellens
R56865, an antiarrhythmic drug with class III effects that terminates ouabain induced ventricular tachycardia in an inverse rate dependent manner.
Cardiovascular research 1993;27(8):1491-7.
1993: T Fazekas; Marc A Vos; Jet D M Leunissen; Hein J J Wellens
Effects of magnesium and ethmozin on ventricular tachycardia induced by ouabain and ventricular pacing in conscious dogs with complete atrioventricular block.
Acta physiologica Hungarica 1993;81(1):59-70.
1992: Anton P Gorgels; Hein J J Wellens; Marc A Vos
Aviation and antiarrhythmic medication.
European heart journal 1992;13 Suppl H():144-8.
1992: Anton P Gorgels; Marc A Vos; Joep L R M Smeets; Hein J J Wellens
Ventricular arrhythmias in heart failure.
The American journal of cardiology 1992;70(10):37C-43C.
1992: Marc A Vos; Anton P Gorgels; Jet D M Leunissen; T van der Nagel; F J Halbertsma; Hein J J Wellens
Further observations to confirm the arrhythmia mechanism-specific effects of flunarizine.
Journal of cardiovascular pharmacology 1992;19(5):682-90.
1992: Marc A Vos; Anton P Gorgels; Jet D M Leunissen; M G Havenith; Erik Kriek; Joep L R M Smeets; Hein J J Wellens
Programmed electrical stimulation and drugs identify two subgroups of ventricular tachycardias occurring 16-24 hours after occlusion of the left anterior descending artery.
Circulation 1992;85(2):747-55.
1991: Marc A Vos; Anton P Gorgels; Jet D M Leunissen; R T van Deursen; Hein J J Wellens
Significance of the number of stimuli to initiate ouabain-induced arrhythmias in the intact heart.
Circulation research 1991;68(1):38-44.
1991: Anton P Gorgels; Marc A Vos; H J Wellens
Premature escape beats in vitro and in vivo.
Circulation 1991;83(1):353-4.
1990: Marc A Vos; Anton P Gorgels; Jet D M Leunissen; Hein J J Wellens
The in vivo response of ouabain-induced arrhythmias to pacing: acceleration instead of termination.
American heart journal 1990;120(3):604-11.
1990: Marc A Vos; Anton P Gorgels; B de Wit; J P Drenth; R T van Deursen; Jet D M Leunissen; Hein J J Wellens
Premature escape beats. A model for triggered activity in the intact heart?
Circulation 1990;82(1):213-24.
1990: Marc A Vos; Anton P Gorgels; Jet D M Leunissen; Hein J J Wellens
Flunarizine allows differentiation between mechanisms of arrhythmias in the intact heart.
Circulation 1990;81(1):343-9.
1989: Marc A Vos; Anton P Gorgels; J D Leunissen-Beekman; Pedro Brugada; Hein J J Wellens
The effect of an entrainment protocol on ouabain-induced ventricular tachycardia.
Pacing and clinical electrophysiology : PACE 1989;12(9):1485-93.
1989: Marc A Vos; Anton P Gorgels; J P Drenth; Jet D M Leunissen; Hein J J Wellens
Termination of ouabain-induced ventricular tachycardia by flunarizine in conscious dogs.
European journal of pharmacology 1989;165(1):139-45.
1988: Anton P Gorgels; Marc A Vos; I S Letsch; E A Verschuuren; Frits W H M Bär; Johan HA Janssen; Hein J J Wellens
Usefulness of the accelerated idioventricular rhythm as a marker for myocardial necrosis and reperfusion during thrombolytic therapy in acute myocardial infarction.
The American journal of cardiology 1988;61(4):231-5.