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Ivan Votruba

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Co-Publications
Name
48
Holý, Antonín
19
Otová, Berta
12
Hocek, Michal
10
Pohl, Radek
7
Holy, Antonin
5
Sladká, M
4
Tloust'ová, Eva
4
Mandys, Václav
3
Masojídková, Milena
3
Otmar, Miroslav
3
Schramlová, Jana
3
Silhár, Peter
3
Zídek, Zdenek
3
Hrebabecký, Hubert
3
Krecmerová, Marcela

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Publications

TOP 3
Cerovský Václav; Budesínský Milos; Hovorka Oldrich; Cvacka Josef; Voburka Zdenek; Slaninová Jirina; Borovicková Lenka; Fucík Vladimír; Bednárová Lucie; Votruba Ivan; Straka Jakub
Lasioglossins: three novel antimicrobial peptides from the venom of the eusocial bee Lasioglossum laticeps (Hymenoptera: Halictidae).
Otová Berta; Hrdy Jirí; Votruba Ivan; Holy Antonín
In vivo modulation of angiogenic gene expression by acyclic nucleoside phosphonates PMEDAP and PMEG.
Naesens Lieve; Andrei Graciela; Votruba Ivan; Krecmerová Marcela; Holý Antonín; Neyts Johan; De Clercq Erik; Snoeck Robert
Intracellular metabolism of the new antiviral compound 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine.

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All Publications

2009: Cerovský Václav; Budesínský Milos; Hovorka Oldrich; Cvacka Josef; Voburka Zdenek; Slaninová Jirina; Borovicková Lenka; Fucík Vladimír; Bednárová Lucie; Votruba Ivan; Straka Jakub
Lasioglossins: three novel antimicrobial peptides from the venom of the eusocial bee Lasioglossum laticeps (Hymenoptera: Halictidae).
Chembiochem : a European journal of chemical biology 2009;10(12):2089-99.
2009: Otová Berta; Hrdy Jirí; Votruba Ivan; Holy Antonín
In vivo modulation of angiogenic gene expression by acyclic nucleoside phosphonates PMEDAP and PMEG.
Anticancer research 2009;29(4):1295-302.
2008: Naesens Lieve; Andrei Graciela; Votruba Ivan; Krecmerová Marcela; Holý Antonín; Neyts Johan; De Clercq Erik; Snoeck Robert
Intracellular metabolism of the new antiviral compound 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine.
Biochemical pharmacology 2008;76(8):997-1005.
2008: Vrábel Milan; Pohl Radek; Votruba Ivan; Sajadi Mohsen; Kovalenko Sergey A; Ernsting Nikolaus P; Hocek Michal
Synthesis and photophysical properties of 7-deaza-2'-deoxyadenosines bearing bipyridine ligands and their Ru(II)-complexes in position 7.
Organic & biomolecular chemistry 2008;6(16):2852-60.
2008: Kuchar Martin; Pohl Radek; Klepetárová Blanka; Votruba Ivan; Hocek Michal
Synthesis of substituted 6-cyclopropylpurine bases and nucleosides by cross-coupling reactions or cyclopropanations.
Organic & biomolecular chemistry 2008;6(13):2377-87.
2008: Silhár Peter; Hocek Michal; Pohl Radek; Votruba Ivan; Shih I-Hung; Mabery Eric; Mackman Richard
Synthesis, cytostatic and anti-HCV activity of 6-(N-substituted aminomethyl)-, 6-(O-substituted hydroxymethyl)- and 6-(S-substituted sulfanylmethyl)purine nucleosides.
Bioorganic & medicinal chemistry 2008;16(5):2329-66.
2008: Pomeisl Karel; Holý Antonín; Votruba Ivan; Pohl Radek
Syntheses of N3-substituted thymine acyclic nucleoside phosphonates and a comparison of their inhibitory effect towards thymidine phosphorylase.
Bioorganic & medicinal chemistry letters 2008;18(4):1364-7.
2008: Hájek Miroslav; Votruba Ivan; Holý Antonín; Krecmerová Marcela; Tloust'ová Eva
Alpha anomer of 5-aza-2'-deoxycytidine down-regulates hTERT mRNA expression in human leukemia HL-60 cells.
Biochemical pharmacology 2008;75(4):965-72.
2008: Kuchar Martin; Hocek Michal; Pohl Radek; Votruba Ivan; Shih I-Hung; Mabery Eric; Mackman Richard
Synthesis, cytostatic, and antiviral activity of novel 6-[2-(dialkylamino)ethyl]-, 6-(2-alkoxyethyl)-, 6-[2-(alkylsulfanyl)ethyl]-, and 6-[2-(dialkylamino)vinyl]purine nucleosides.
Bioorganic & medicinal chemistry 2008;16(3):1400-24.
2008: Pomeisl Karel; Holý Anonín; Votruba Ivan
Pyrimidine acyclic nucleoside phosphonates and phosphorylated analogs. Part 2. Syntheses and investigation of their inhibitory effects towards human thymidine phosphorylase.
Nucleic acids symposium series (2004) 2008;(52):657-8.
2007: Nencka Radim; Votruba Ivan; Hrebabecký Hubert; Jansa Petr; Tloust'ová Eva; Horská Kveta; Masojídková Milena; Holý Antonín
Discovery of 5-substituted-6-chlorouracils as efficient inhibitors of human thymidine phosphorylase.
Journal of medicinal chemistry 2007;50(24):6016-23.
2007: Vrábel Milan; Pohl Radek; Klepetárová Blanka; Votruba Ivan; Hocek Michal
Synthesis of 2'-deoxyadenosine nucleosides bearing bipyridine-type ligands and their Ru-complexes in position 8 through cross-coupling reactions.
Organic & biomolecular chemistry 2007;5(17):2849-57.
2007: Fojtova Miloslava; Piskala Alois; Votruba Ivan; Otmar Miroslav; Bartova Eva; Kovarik Ales
Efficacy of DNA hypomethylating capacities of 5-aza-2'-deoxycytidine and its alpha anomer.
Pharmacological research : the official journal of the Italian Pharmacological Society 2007;55(1):16-22.
2007: Pomeisl Karel; Votruba Ivan; Holý Antonín; Pohl Radek
Syntheses of pyrimidine acyclic nucleoside phosphonates as potent inhibitors of thymidine phosphorylase (PD-ECGF) from SD-lymphoma.
Nucleosides, nucleotides & nucleic acids 2007;26(8-9):1025-8.
2007: Zápotocký M; Hanzalová J; Starková J; Votruba I; Holý A; Otová B
Experimental therapy with 9-[2-(phosphonomethoxy)ethyl]-2,6-diaminopurine (PMEDAP): origin of resistance.
Folia biologica 2007;53(3):79-84.
2006: Schinkmanová Markéta; Votruba Ivan; Holý Antonín
N6-methyl-AMP aminohydrolase activates N6-substituted purine acyclic nucleoside phosphonates.
Biochemical pharmacology 2006;71(9):1370-6.
2006: Nencka Radim; Votruba Ivan; Hrebabecký Hubert; Tloust'ová Eva; Horská Kveta; Masojídková Milena; Holý Antonín
Design and synthesis of novel 5,6-disubstituted uracil derivatives as potent inhibitors of thymidine phosphorylase.
Bioorganic & medicinal chemistry letters 2006;16(5):1335-7.
2005: Hocek Michal; Naus Petr; Pohl Radek; Votruba Ivan; Furman Phillip A; Tharnish Phillip M; Otto Michael J
Cytostatic 6-arylpurine nucleosides. 6. SAR in anti-HCV and cytostatic activity of extended series of 6-hetarylpurine ribonucleosides.
Journal of medicinal chemistry 2005;48(18):5869-73.
2005: Hájek Miroslav; Matulová Nadezda; Votruba Ivan; Holý Antonín; Tloust'ová Eva
Inhibition of human telomerase by diphosphates of acyclic nucleoside phosphonates.
Biochemical pharmacology 2005;70(6):894-900.
2005: Silhár Peter; Pohl Radek; Votruba Ivan; Hocek Michal
The first synthesis and cytostatic activity of novel 6-(fluoromethyl)purine bases and nucleosides.
Organic & biomolecular chemistry 2005;3(16):3001-7.
2005: Votruba Ivan; Pomeisl Karel; Tloust'ová Eva; Holý Antonín; Otová Berta
Inhibition of thymidine phosphorylase (PD-ECGF) from SD-lymphoma by phosphonomethoxyalkyl thymines.
Biochemical pharmacology 2005;69(10):1517-21.
2004: Turek Pavel; Kotora Martin; Tislerová Iva; Hocek Michal; Votruba Ivan; Císarová Ivana
Cocyclotrimerization of 6-alkynylpurines with alpha,omega-diynes as a novel approach to biologically active 6-arylpurines.
The Journal of organic chemistry 2004;69(26):9224-33.
2004: Silhár Peter; Pohl Radek; Votruba Ivan; Hocek Michal
Facile and efficient synthesis of 6-(hydroxymethyl)purines.
Organic letters 2004;6(19):3225-8.
2004: Otmar Miroslav; Masojídková Milena; Votruba Ivan; Holý Antonín
Synthesis and antiproliferative activity of 2,6-diamino-9-benzyl-9-deazapurine and related compounds.
Bioorganic & medicinal chemistry 2004;12(12):3187-95.
2004: Hocek Michal; Stepnicka Petr; Ludvík Jirí; Císarová Ivana; Votruba Ivan; Reha David; Hobza Pavel
Ferrocene-modified purines as potential electrochemical markers: synthesis, crystal structures, electrochemistry and cytostatic activity of (ferrocenylethynyl)- and (ferrocenylethyl)purines.
Chemistry (Weinheim an der Bergstrasse, Germany) 2004;10(8):2058-66.
2004: Birkus Gabriel; Rejman Dominik; Otmar Miroslav; Votruba Ivan; Rosenberg Ivan; Holy Antonin
The substrate activity of (S)-9-[3-hydroxy-(2-phosphonomethoxy)propyl]adenine diphosphate toward DNA polymerases alpha, delta and epsilon.
Antiviral chemistry & chemotherapy 2004;15(1):23-33.
2003: Valeriánová Marie; Otová Berta; Bílá Vlasta; Hanzalová Jitka; Votruba Ivan; Holý Antonín; Eckschlager Tomás; Krejcí Ondrej; Trka Jan
PMEDAP and its N6-substituted derivatives: genotoxic effect and apoptosis in in vitro conditions.
Anticancer research 2003;23(6C):4933-9.
2002: Birkus Gabriel; Hájek Miroslav; Kramata Pavel; Votruba Ivan; Holý Antonín; Otová Berta
Tenofovir diphosphate is a poor substrate and a weak inhibitor of rat DNA polymerases alpha, delta, and epsilon*.
Antimicrobial agents and chemotherapy 2002;46(5):1610-3.
2002: Holý Antonín; Votruba Ivan; Masojídková Milena; Andrei Graciela; Snoeck Robert; Naesens Lieve; De Clercq Erik; Balzarini Jan
6-[2-(Phosphonomethoxy)alkoxy]pyrimidines with antiviral activity.
Journal of medicinal chemistry 2002;45(9):1918-29.
2002: Hocek Michal; Votruba Ivan
Covalent analogues of DNA base-pairs and triplets. Part 2: synthesis and cytostatic activity of bis(purin-6-yl)acetylenes,-diacetylenes and related compounds.
Bioorganic & medicinal chemistry letters 2002;12(7):1055-8.
2001: Bobkov K; Gut I; Mandys V; Holý A; Votruba I; Otová B
Antitumour activity of a combined treatment with PMEDAP and docetaxel in the Prague inbred Sprague-Dawley/cub rat strain bearing T-cell lymphoma.
Anticancer research 2001;21(4A):2725-31.
2001: Valeriánová M; Votruba I; Holy A; Mandys V; Otová B
Antitumour activity of N6-substituted PMEDAP derivatives against T-cell lymphoma.
Anticancer research 2001;21(3B):2057-64.
2000: Krejcová R; Horská K; Votruba I; Holý A
Interaction of guanine phosphonomethoxyalkyl derivatives with GMP kinase isoenzymes.
Biochemical pharmacology 2000;60(12):1907-13.
2000: Hocek M; Holý A; Votruba I; Dvoráková H
Synthesis and cytostatic activity of substituted 6-phenylpurine bases and nucleosides: application of the Suzuki-Miyaura cross-coupling reactions of 6-chloropurine derivatives with phenylboronic acids.
Journal of medicinal chemistry 2000;43(9):1817-25.
2000: Bobková K; Otová B; Marinov I; Mandys V; Panczak A; Votruba I; Holý A
Anticancer effect of PMEDAP--monitoring of apoptosis.
Anticancer research 2000;20(2A):1041-7.
1999: Votruba I; Krecmerová M; Hrebabecký H; Holý A
Inhibitory potency of 5-benzyluracil, 5-phenylcytosine and 5-phenylpyrimidin-2-one nucleosides against uridine phosphorylase from mouse leukemic L1210 cells.
Nucleosides & nucleotides 1999;18(11-12):2551-64.
1999: Birkus G; Votruba I; Holý A; Otová B
9-[2-(Phosphonomethoxy)ethyl]adenine diphosphate (PMEApp) as a substrate toward replicative DNA polymerases alpha, delta, epsilon, and epsilon*.
Biochemical pharmacology 1999;58(3):487-92.
1999: Otová B; Francová K; Franek F; Koutník P; Votruba I; Holy A; Sladká M; Schramlová J
9-[2-(phosphonomethoxy)ethyl]-2,6-diaminopurine (PMEDAP)--a potential drug against hematological malignancies--induces apoptosis.
Anticancer research 1999;19(4B):3173-82.
1999: Franek F; Holy A; Votruba I; Eckschlager T
Acyclic nucleotide analogues suppress growth and induce apoptosis in human leukemia cell lines.
International journal of oncology 1999;14(4):745-52.
1999: Otová B; Mráz M; Mandys V; Panczak A; Schramlová J; Votruba I; Holy A
Therapeutic effect of heat shock on T-cell lymphoma in inbred Sprague-Dawley rat.
Folia biologica 1999;45(4):121-31.
1998: Fojtová M; Kovarík A; Votruba I; Holý A
Evaluation of the impact of S-adenosylhomocysteine metabolic pools on cytosine methylation of the tobacco genome.
European journal of biochemistry / FEBS 1998;252(3):347-52.
1997: Otová B; Zídek Z; Holý A; Votruba I; Sladká M; Marinov I; Lesková V
Antitumor activity of novel purine acyclic nucleotide analogs PMEA and PMEDAP.
In vivo (Athens, Greece) 1997;11(2):163-7.
1997: Otová B; Holý A; Votruba I; Sladká M; Bílá V; Mejsnarová B; Lesková V
Genotoxicity of purine acyclic nucleotide analogs.
Folia biologica 1997;43(6):225-9.
1996: Kramata P; Votruba I; Otová B; Holý A
Different inhibitory potencies of acyclic phosphonomethoxyalkyl nucleotide analogs toward DNA polymerases alpha, delta and epsilon.
Molecular pharmacology 1996;49(6):1005-11.
1995: Cihlár T; Rosenberg I; Votruba I; Holý A
Transport of 9-(2-phosphonomethoxyethyl)adenine across plasma membrane of HeLa S3 cells is protein mediated.
Antimicrobial agents and chemotherapy 1995;39(1):117-24.
1994: Stetina R; Votruba I; Holý A; Merta A
The effect of purine phosphonomethoxyalkyl derivatives on DNA synthesis in CHO Chinese hamster cells.
Neoplasma 1994;41(1):61-6.
1994: Otová B; Zídek Z; Holý A; Votruba I; Franková D
Immunomodulatory properties of 9-(2-phosphonomethoxyethyl)-adenine (PMEA).
Folia biologica 1994;40(4):185-92.
1993: Balzarini J; Karlsson A; Wang L; Bohman C; Horská K; Votruba I; Fridland A; Van Aerschot A; Herdewijn P; De Clercq E
Eicar (5-ethynyl-1-beta-D-ribofuranosylimidazole-4-carboxamide). A novel potent inhibitor of inosinate dehydrogenase activity and guanylate biosynthesis.
The Journal of biological chemistry 1993;268(33):24591-8.
1993: Stetina R; Votruba I; Holý A; Merta A
The effect of purine phosphonomethoxyalkyl derivatives on DNA synthesis in CHO Chinese hamster cells.
Neoplasma 1993;40(6):373-8.
1993: Otová B; Sladká M; Blazek K; Schramlová J; Votruba I; Holý A
Cytostatic effect of 9-(2-phosphonomethoxyethyl) adenine (PMEA). II. Lymphoblastic leukemia in Sprague-Dawley rats.
Folia biologica 1993;39(3):142-9.
1993: Otová B; Sladká M; Votruba I; Holý A; Kren V
Cytostatic effect of 9-(2-phosphonomethoxyethyl) adenine (PMEA). I. Lymphatic leukemia KHP-Lw-I in Lewis rats.
Folia biologica 1993;39(3):136-41.
1993: Otová B; Krenová D; Zídek Z; Holý A; Votruba I; Kren V
Cytostatic effect of 9-(2-phosphonomethoxyethyl) adenine (PMEA). III. Rat and mouse carcinomas and sarcomas.
Folia biologica 1993;39(6):311-4.
1992: Merta A; Votruba I; Jindrich J; Holý A; Cihlár T; Rosenberg I; Otmar M; Herve T Y
Phosphorylation of 9-(2-phosphonomethoxyethyl)adenine and 9-(S)-(3-hydroxy-2-phosphonomethoxypropyl)adenine by AMP(dAMP) kinase from L1210 cells.
Biochemical pharmacology 1992;44(10):2067-77.
1992: Otová B; Votruba I; Holý A
Pretreatment of the host cell with 1-(S)-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine (HPMPC) is sufficient for its antiviral effect.
Acta virologica 1992;36(3):313-9.
1991: Ewing D F; Holý A; Votruba I; Humble R W; Mackenzie G; Hewedi F; Shaw G
Synthesis of 4- and 5-amino-1-(2-deoxy-D-erythro-pentofuranosyl)imidazole nucleosides by chemical and biotransformation methods.
Carbohydrate research 1991;216():109-18.
1990: Vonka V; Anisimová E; Cerný J; Holý A; Rosenberg I; Votruba I
Properties of a 9-(2-phosphonylmethoxyethyl)adenine (PMEA)-resistant herpes simplex virus type 1 virus mutant.
Antiviral research 1990;14(2):117-21.
1990: Holý A; Votruba I; Merta A; Cerný J; Veselý J; Vlach J; Sedivá K; Rosenberg I; Otmar M; Hrebabecký H
Acyclic nucleotide analogues: synthesis, antiviral activity and inhibitory effects on some cellular and virus-encoded enzymes in vitro.
Antiviral research 1990;13(6):295-311.
1990: Votruba I; Trávnícek M; Rosenberg I; Otmar M; Merta A; Hrebabecký H; Holý A
Inhibition of avian myeloblastosis virus reverse transcriptase by diphosphates of acyclic phosphonylmethyl nucleotide analogues.
Antiviral research 1990;13(6):287-93.
1990: Votruba I; Hasobe M; Holý A; Borchardt R T
2-Methylpropyl ester of 3-(adenin-9-yl)-2-hydroxypropanoic acid. Mechanism of antiviral action in vaccinia virus-infected L929 cells.
Biochemical pharmacology 1990;39(10):1573-80.
1990: Cerný J; Votruba I; Vonka V; Rosenberg I; Otmar M; Holý A
Phosphonylmethyl ethers of acyclic nucleoside analogues: inhibitors of HSV-1 induced ribonucleotide reductase.
Antiviral research 1990;13(5):253-64.
1990: Merta A; Votruba I; Rosenberg I; Otmar M; Hrebabecký H; Bernaerts R; Holý A
Inhibition of herpes simplex virus DNA polymerase by diphosphates of acyclic phosphonylmethoxyalkyl nucleotide analogues.
Antiviral research 1990;13(5):209-18.
1990: Veselý J; Merta A; Votruba I; Rosenberg I; Holý A
The cytostatic effects and mechanism of action of antiviral acyclic adenine nucleotide analogs in L1210 mouse leukemia cells.
Neoplasma 1990;37(2):105-10.
1990: Merta A; Veselý J; Votruba I; Rosenberg I; Holý A
Phosphorylation of acyclic nucleotide analogs HPMPA and PMEA in L1210 mouse leukemia cell extracts.
Neoplasma 1990;37(2):111-20.
1989: Ewing D; Humble R W; Holy A; Mackenzie G; Shaw G; Votruba I
Synthesis of 2-deoxy-D-ribofuranosyl 5-amino- and 5-hydroxyaminoimidazole nucleosides by chemical methods and biotransformation.
Nucleic acids symposium series 1989;(21):97-8.
1987: Votruba I; Bernaerts R; Sakuma T; De Clercq E; Merta A; Rosenberg I; Holý A
Intracellular phosphorylation of broad-spectrum anti-DNA virus agent (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine and inhibition of viral DNA synthesis.
Molecular pharmacology 1987;32(4):524-9.
1987: Holý A; Votruba I
Facile preparation of purine and pyrimidine 2-deoxy-beta-D-ribonucleosides by biotransformation on encapsulated cells.
Nucleic acids symposium series 1987;(18):69-72.
1985: Holý A; Rosenberg I; Votruba I; Sláma K
Metabolic phosphorylation and excretion of some nucleoside analogues in insects.
Biological chemistry Hoppe-Seyler 1985;366(4):355-9.
1984: Schanche J S; Schanche T; Ueland P M; Holý A; Votruba I
The effect of aliphatic adenine analogues on S-adenosylhomocysteine and S-adenosylhomocysteine hydrolase in intact rat hepatocytes.
Molecular pharmacology 1984;26(3):553-8.
1983: Votruba I; Holý A; De Clercq E
Metabolism of the broad-spectrum antiviral agent, 9-(S)-(2,3-dihydroxypropyl) adenine, in different cell lines.
Acta virologica 1983;27(3):273-6.
1981: Jelínek R; Holý A; Votruba I
Embryotoxicity of 9-(S)-(2,3-dihydroxypropyl)adenine.
Teratology 1981;24(3):267-75.
1980: Rada B; Dragún M; Votruba I; Holý A
Characteristics of the antiviral effect of 9-(S)-(2, 3-dihydroxypropyl)adenine.
Acta virologica 1980;24(6):433-8.

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