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Susanne Vrtala

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Margit Weghofer; Anne Casset; Enrique Fernández-Caldas; Rosetta Ferrara; Monika Grote; Friedrich Horak; Michael Kabesch; Walter Keller; Michael Kneidinger; Jolanta Kopec; Adriano Mari; Gabrielle Pauli; Ashok Purohit; Yvonne Resch; WR Thomas; Peter Valent; Rudolf Valenta; Susanne Vrtala
Identification of Der p 23, a peritrophin-like protein, as a new major Dermatophagoides pteronyssinus allergen associated with the peritrophic matrix of mite fecal pellets.
Alexandra Baar; Claudia Constantin; Christof Ebner; Stavroula Giavi; Adriano Mari; Sandra Pahr; Nikolaos G Papadopoulos; Sandra Scheiblhofer; Josef Thalhamer; Susanne Vrtala; Rudolf Valenta
Molecular and immunological characterization of Tri a 36, a low molecular weight glutenin, as a novel major wheat food allergen.
J Eckl-Dorna; K Marth; K-W Chen; Ines Pree; Jürgen Reisinger; Susanne Spitzauer; Rudolf Valenta; Susanne Vrtala; Verena Niederberger
The majority of allergen-specific IgE in the blood of allergic patients does not originate from blood-derived B cells or plasma cells.

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2013: Margit Weghofer; Anne Casset; Enrique Fernández-Caldas; Rosetta Ferrara; Monika Grote; Friedrich Horak; Michael Kabesch; Walter Keller; Michael Kneidinger; Jolanta Kopec; Adriano Mari; Gabrielle Pauli; Ashok Purohit; Yvonne Resch; WR Thomas; Peter Valent; Rudolf Valenta; Susanne Vrtala
Identification of Der p 23, a peritrophin-like protein, as a new major Dermatophagoides pteronyssinus allergen associated with the peritrophic matrix of mite fecal pellets.
Journal of immunology (Baltimore, Md. : 1950) 2013;190(7):3059-67.
2012: Alexandra Baar; Claudia Constantin; Christof Ebner; Stavroula Giavi; Adriano Mari; Sandra Pahr; Nikolaos G Papadopoulos; Sandra Scheiblhofer; Josef Thalhamer; Susanne Vrtala; Rudolf Valenta
Molecular and immunological characterization of Tri a 36, a low molecular weight glutenin, as a novel major wheat food allergen.
Journal of immunology (Baltimore, Md. : 1950) 2012;189(6):3018-25.
2012: J Eckl-Dorna; K Marth; K-W Chen; Ines Pree; Jürgen Reisinger; Susanne Spitzauer; Rudolf Valenta; Susanne Vrtala; Verena Niederberger
The majority of allergen-specific IgE in the blood of allergic patients does not originate from blood-derived B cells or plasma cells.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2012;42(9):1347-55.
2012: Kuan-Wei Chen; Ines Swoboda; WR Thomas; Peter Valent; Rudolf Valenta; Katharina Blatt; Susanne Vrtala
Hypoallergenic Der p 1/Der p 2 combination vaccines for immunotherapy of house dust mite allergy.
The Journal of allergy and clinical immunology 2012;130(2):435-43.e4.
2012: K-W Chen; Fabio Dall'Antonia; I Faé; G Fischer; Margarete Focke-Tejkl; A Gieras; Walter Keller; M Kneidinger; Peter Valent; Rudolf Valenta; K Blatt; Susanne Vrtala
Carrier-bound nonallergenic Der p 2 peptides induce IgG antibodies blocking allergen-induced basophil activation in allergic patients.
Allergy 2012;67(5):609-21.
2012: S Pahr; Sandra Scheiblhofer; Josef Thalhamer; C Constantin; Christof Ebner; Fatima Ferreira; Irene Mittermann; Susanne Vrtala; Rudolf Valenta
Molecular characterization of wheat allergens specifically recognized by patients suffering from wheat-induced respiratory allergy.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2012;42(4):597-609.
2012: Anne Casset; Kuan-Wei Chen; Frédéric de Blay; Rosetta Ferrara; Adriano Mari; Ashok Purohit; Yvonne Resch; WR Thomas; Rudolf Valenta; Claudia Alessandri; Margit Weghofer; Susanne Vrtala
Varying allergen composition and content affects the in vivo allergenic activity of commercial Dermatophagoides pteronyssinus extracts.
International archives of allergy and immunology 2012;159(3):253-62.
2011: Susanne Vrtala; Monika Fohr; Raffaela Campana; Christian Baumgartner; Peter Valent; Rudolf Valenta
Genetic engineering of trimers of hypoallergenic fragments of the major birch pollen allergen, Bet v 1, for allergy vaccination.
Vaccine 2011;29(11):2140-8.
2011: Raffaela Campana; Susanne Vrtala; Bernhard Maderegger; Yuliya Dall'Antonia; Domen Zafred; Katharina Blatt; Harald Herrmann; Margarete Focke-Tejkl; Ines Swoboda; Sandra Scheiblhofer; Anna Gieras; Angela Neubauer; Walter Keller; Peter Valent; Josef Thalhamer; Susanne Spitzauer; Rudolf Valenta
Altered IgE epitope presentation: A model for hypoallergenic activity revealed for Bet v 1 trimer.
Molecular immunology 2011;48(4):431-41.
2010: Cornelia Egger; Friedrich Horak; Susanne Vrtala; Rudolf Valenta; Verena Niederberger
Nasal application of rBet v 1 or non-IgE-reactive T-cell epitope-containing rBet v 1 fragments has different effects on systemic allergen-specific antibody responses.
The Journal of allergy and clinical immunology 2010;126(6):1312-5.e4.
2010: Raffaela Campana; Susanne Vrtala; Bernhard Maderegger; Peter Jertschin; Gottfried Stegfellner; Ines Swoboda; Margarete Focke-Tejkl; Katharina Blatt; Anna Gieras; Domen Zafred; Angela Neubauer; Peter Valent; Walter Keller; Susanne Spitzauer; Rudolf Valenta
Hypoallergenic derivatives of the major birch pollen allergen Bet v 1 obtained by rational sequence reassembly.
The Journal of allergy and clinical immunology 2010;126(5):1024-31, 1031.e1-8.
2010: Jean-Pierre Allam; Peter A Würtzen; Markus Reinartz; Jochen Winter; Susanne Vrtala; Kuan-Wei Chen; Rudolf Valenta; Matthias Wenghoefer; Thorsten Appel; Eva Gros; Bernd Niederhagen; Thomas Bieber; Kaare Lund; Natalija Novak
Phl p 5 resorption in human oral mucosa leads to dose-dependent and time-dependent allergen binding by oral mucosal Langerhans cells, attenuates their maturation, and enhances their migratory and TGF-beta1 and IL-10-producing properties.
The Journal of allergy and clinical immunology 2010;126(3):638-45.e1.
2010: Rudolf Valenta; Fatima Ferreira; Margarete Focke-Tejkl; Birgit Linhart; Verena Niederberger; Ines Swoboda; Susanne Vrtala
From allergen genes to allergy vaccines.
Annual review of immunology 2010;28():211-41.
2010: E Gadermaier; Sabine Flicker; W Aberer; C Egger; N Reider; Margarete Focke; Susanne Vrtala; Michael Kundi; Rudolf Valenta
Analysis of the antibody responses induced by subcutaneous injection immunotherapy with birch and Fagales pollen extracts adsorbed onto aluminum hydroxide.
International archives of allergy and immunology 2010;151(1):17-27.
2009: K Gangl; Renate Reininger; D Bernhard; R Campana; Ines Pree; Jürgen Reisinger; M Kneidinger; Michael Kundi; Helmut Dolznig; Dietmar Thurnher; Peter Valent; K-W Chen; Susanne Vrtala; Susanne Spitzauer; Rudolf Valenta; Verena Niederberger
Cigarette smoke facilitates allergen penetration across respiratory epithelium.
Allergy 2009;64(3):398-405.
2008: Margit Weghofer; WR Thomas; M Kronqvist; Adriano Mari; A Purohit; Gabrielle Pauli; Friedrich Horak; Hans Grönlund; Marianne van Hage; Rudolf Valenta; Susanne Vrtala
Variability of IgE reactivity profiles among European mite allergic patients.
European journal of clinical investigation 2008;38(12):959-65.
2008: Birgit Linhart; Nadine Mothes-Luksch; Susanne Vrtala; Michael Kneidinger; Peter Valent; Rudolf Valenta
A hypoallergenic hybrid molecule with increased immunogenicity consisting of derivatives of the major grass pollen allergens, Phl p 2 and Phl p 6.
Biological chemistry 2008;389(7):925-33.
2008: Margit Weghofer; Y Dall'Antonia; Monika Grote; Angelika Stöcklinger; M Kneidinger; Nadja Balic; Maria-Theresa Krauth; E Fernández-Caldas; WR Thomas; Marianne van Hage; Stefan Vieths; Susanne Spitzauer; Friedrich Horak; D I Svergun; P V Konarev; Peter Valent; Josef Thalhamer; Walter Keller; Rudolf Valenta; Susanne Vrtala
Characterization of Der p 21, a new important allergen derived from the gut of house dust mites.
Allergy 2008;63(6):758-67.
2008: Kuan-Wei Chen; Gudrun Fuchs; Karoline Sonneck; Anna Gieras; Ines Swoboda; Nikolas Douladiris; Birgit Linhart; Marija Jankovic; Tea Pavkov; Walter Keller; Nikolaos Papadopoulos; Peter Valent; Rudolf Valenta; Susanne Vrtala
Reduction of the in vivo allergenicity of Der p 2, the major house-dust mite allergen, by genetic engineering.
Molecular immunology 2008;45(9):2486-98.
2008: Michael Kneidinger; Uwe Schmidt; Uwe Rix; Karoline V Gleixner; Anja Vales; Christian Baumgartner; Christian Lupinek; Margit Weghofer; Keiryn Bennett; Harald Herrmann; Alexandra Schebesta; WR Thomas; Susanne Vrtala; Rudolf Valenta; Francis Y Lee; Wilfried Ellmeier; Giulio Superti-Furga; Peter Valent
The effects of dasatinib on IgE receptor-dependent activation and histamine release in human basophils.
Blood 2008;111(6):3097-107.
2008: Susanne Vrtala
From allergen genes to new forms of allergy diagnosis and treatment.
Allergy 2008;63(3):299-309.
2008: Krisztina Szalai; Jan Fuhrmann; Tea Pavkov; Michael Scheidl; Julia Wallmann; Kira H Brämswig; Susanne Vrtala; Otto Scheiner; Walter Keller; Jean-Marie Saint-Remy; Dirk Neumann; Isabella Pali-Schöll; Erika Jensen-Jarolim
Mimotopes identify conformational B-cell epitopes on the two major house dust mite allergens Der p 1 and Der p 2.
Molecular immunology 2008;45(5):1308-17.
2008: Raffaela Campana; Nadine Mothes; Ingrid Rauter; Susanne Vrtala; Renate Reininger; Margarete Focke-Tejkl; Christian Lupinek; Nadja Balic; Susanne Spitzauer; Rudolf Valenta
Non-IgE-mediated chronic allergic skin inflammation revealed with rBet v 1 fragments.
The Journal of allergy and clinical immunology 2008;121(2):528-530.e1.
2008: Margit Weghofer; Monika Grote; Yuliya Dall'Antonia; Enrique Fernández-Caldas; Maria-Theresa Krauth; Marianne van Hage; Friedrich Horak; WR Thomas; Peter Valent; Walter Keller; Rudolf Valenta; Susanne Vrtala
Characterization of folded recombinant Der p 5, a potential diagnostic marker allergen for house dust mite allergy.
International archives of allergy and immunology 2008;147(2):101-9.
2008: Karoline Sonneck; Christian Baumgartner; Laura Rebuzzi; K Marth; Kuan-Wei Chen; Alexander W Hauswirth; Stefan Florian; Susanne Vrtala; Hans-Jörg Bühring; Rudolf Valenta; Peter Valent
Recombinant allergens promote expression of aminopeptidase-n (CD13) on basophils in allergic patients.
International journal of immunopathology and pharmacology 2008;21(1):11-21.
2007: Ines Pree; Jürgen Reisinger; Margarete Focke; Susanne Vrtala; Gabrielle Pauli; Marianne van Hage; Oliver Cromwell; Elisabeth Gadermaier; Cornelia Egger; Norbert Reider; Friedrich Horak; Rudolf Valenta; Verena Niederberger
Analysis of epitope-specific immune responses induced by vaccination with structurally folded and unfolded recombinant Bet v 1 allergen derivatives in man.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(8):5309-16.
2007: Caroline Bussmann; Laura Maintz; J Hart; Jean-Pierre Allam; Susanne Vrtala; Kuan-Wei Chen; Thomas Bieber; WR Thomas; Rudolf Valenta; T Zuberbier; A Sager; Natalija Novak
Clinical improvement and immunological changes in atopic dermatitis patients undergoing subcutaneous immunotherapy with a house dust mite allergoid: a pilot study.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2007;37(9):1277-85.
2007: Susanne Vrtala; Margarete Focke; Jolanta Kopec; Petra Verdino; Arnulf Hartl; Wolfgang R Sperr; Alexander A Fedorov; Tanja Ball; Steven C Almo; Peter Valent; Josef Thalhamer; Walter Keller; Rudolf Valenta
Genetic engineering of the major timothy grass pollen allergen, Phl p 6, to reduce allergenic activity and preserve immunogenicity.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(3):1730-9.
2007: Debra A Stern; Josef Riedler; Dennis Nowak; Charlotte Braun-Fahrlander; Ines Swoboda; Nadja Balic; Kuan-Wei Chen; Susanne Vrtala; Hans Grönlund; Marianne van Hage; Rudolf Valenta; Susanne Spitzauer; Erika von Mutius; Donata Vercelli
Exposure to a farming environment has allergen-specific protective effects on TH2-dependent isotype switching in response to common inhalants.
The Journal of allergy and clinical immunology 2007;119(2):351-8.
2006: Maximilian Gabler; Sandra Scheiblhofer; Kerstin Kern; Wolfgang W Leitner; Angelika Stoecklinger; Cornelia Hauser-Kronberger; Beate Alinger; Berta Lechner; Monika Prinz; Susanne Vrtala; Rudolf Valenta; Josef Thalhamer; Richard Weiss
Immunization with a low-dose replicon DNA vaccine encoding Phl p 5 effectively prevents allergic sensitization.
The Journal of allergy and clinical immunology 2006;118(3):734-41.
2006: Ingrid Rauter; Maria-Theresa Krauth; Sabine Flicker; Anna Gieras; Kerstin Westritschnig; Susanne Vrtala; Nadja Balic; Susanne Spitzauer; Johannes Huss-Marp; Knut Brockow; Ulf Darsow; Johannes Ring; Heidrun Behrendt; Hans Semper; Peter Valent; Rudolf Valenta
Allergen cleavage by effector cell-derived proteases regulates allergic inflammation.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(7):967-9.
2006: Birgit Winkler; Karin Hufnagl; Andreas Spittler; Martin Ploder; Enikö Kállay; Susanne Vrtala; Rudolf Valenta; Michael Kundi; Harald Renz; Ursula Wiedermann
The role of Foxp3+ T cells in long-term efficacy of prophylactic and therapeutic mucosal tolerance induction in mice.
Allergy 2006;61(2):173-80.
2006: Eleonora Dehlink; Thomas Eiwegger; Marianne Gerstmayr; E Kampl; Barbara Bohle; Kuan-Wei Chen; Susanne Vrtala; Radvan Urbanek; Zsolt Szépfalusi
Absence of systemic immunologic changes during dose build-up phase and early maintenance period in effective specific sublingual immunotherapy in children.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2006;36(1):32-9.
2005: Margit Weghofer; WR Thomas; G Pittner; Friedrich Horak; Rudolf Valenta; Susanne Vrtala
Comparison of purified Dermatophagoides pteronyssinus allergens and extract by two-dimensional immunoblotting and quantitative immunoglobulin E inhibitions.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2005;35(10):1384-91.
2005: Gernot Sellge; Sylvia Laffer; CT Mierke; Susanne Vrtala; M W Hoffmann; Jürgen Klempnauer; Michael P Manns; Rudolf Valenta; Stephan C Bischoff
Development of an in vitro system for the study of allergens and allergen-specific immunoglobulin E and immunoglobulin G: Fcepsilon receptor I supercross-linking is a possible new mechanism of immunoglobulin G-dependent enhancement of type I allergic reactions.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2005;35(6):774-81.
2004: Verena Niederberger; Friedrich Horak; Susanne Vrtala; Susanne Spitzauer; Maria-Theresa Krauth; Peter Valent; Jürgen Reisinger; Martina Pelzmann; Brigitte Hayek; Marianne Kronqvist; Guro Gafvelin; Hans Grönlund; Ashok Purohit; Roland Suck; Helmut Fiebig; Oliver Cromwell; Gabrielle Pauli; Marianne Van Hage-Hamsten; Rudolf Valenta
Vaccination with genetically engineered allergens prevents progression of allergic disease.
Proceedings of the National Academy of Sciences of the United States of America 2004;101 Suppl 2():14677-82.
2004: G Pittner; Susanne Vrtala; WR Thomas; Margit Weghofer; Michael Kundi; Friedrich Horak; Dietrich Kraft; Rudolf Valenta
Component-resolved diagnosis of house-dust mite allergy with purified natural and recombinant mite allergens.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2004;34(4):597-603.
2004: Susanne Vrtala; Margarete Focke-Tejkl; Ines Swoboda; Dietrich Kraft; Rudolf Valenta
Strategies for converting allergens into hypoallergenic vaccine candidates.
Methods (San Diego, Calif.) 2004;32(3):313-20.
2004: Rudolf Valenta; Tanja Ball; Margarete Focke; Birgit Linhart; Nadine Mothes; Verena Niederberger; Susanne Spitzauer; Ines Swoboda; Susanne Vrtala; Kerstin Westritschnig; Dietrich Kraft
Immunotherapy of allergic disease.
Advances in immunology 2004;82():105-53.
2004: Vera Mahler; Susanne Vrtala; Oliver Kuss; Thomas L Diepgen; Roland Suck; Oliver Cromwell; Helmut Fiebig; Arnulf Hartl; Josef Thalhamer; G Schuler; D Kraft; R Valenta
Vaccines for birch pollen allergy based on genetically engineered hypoallergenic derivatives of the major birch pollen allergen, Bet v 1.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2004;34(1):115-22.
2003: Romana Hochreiter; Tatjana Stepanoska; Fatima Ferreira; Rudolf Valenta; Susanne Vrtala; Josef Thalhamer; Arnulf Hartl
Prevention of allergen-specific IgE production and suppression of an established Th2-type response by immunization with DNA encoding hypoallergenic allergen derivatives of Bet v 1, the major birch-pollen allergen.
European journal of immunology 2003;33(6):1667-76.
2003: Kerstin Westritschnig; E Sibanda; W Thomas; Herbert Auer; Horst Aspöck; G Pittner; Susanne Vrtala; Susanne Spitzauer; Dietrich Kraft; Rudolf Valenta
Analysis of the sensitization profile towards allergens in central Africa.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2003;33(1):22-7.
2002: Hans Grönlund; Susanne Vrtala; Ursula Wiedermann; Gerhard Dekan; Dietrich Kraft; Rudolf Valenta; Marianne Van Hage-Hamsten
Carbohydrate-based particles: a new adjuvant for allergen-specific immunotherapy.
Immunology 2002;107(4):523-9.
2002: Marianne Van Hage-Hamsten; Eva Johansson; Annika Roquet; C Peterson; M Andersson; L Greiff; Susanne Vrtala; Rudolf Valenta; Reidar Grönneberg
Nasal challenges with recombinant derivatives of the major birch pollen allergen Bet v 1 induce fewer symptoms and lower mediator release than rBet v 1 wild-type in patients with allergic rhinitis.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2002;32(10):1448-53.
2002: Ornella Maglio; Jose W Saldanha; Susanne Vrtala; Susanne Spitzauer; Rudolf Valenta; Annalisa Pastore
A major IgE epitope-containing grass pollen allergen domain from Phl p 5 folds as a four-helix bundle.
Protein engineering 2002;15(8):635-42.
2002: Rudolf Valenta; Susanne Vrtala; Margarete Focke-Tejkl; Anna Twardosz; Ines Swoboda; Agnes Bugajska-Schretter; Susanne Spitzauer; Dietrich Kraft
Synthetic and genetically engineered allergen derivatives for specific immunotherapy of type I allergy.
Clinical allergy and immunology 2002;16():495-517.
2001: Ursula Wiedermann; Udo Herz; Karin Baier; Susanne Vrtala; Ulrich Neuhaus-Steinmetz; Barbara Bohle; Gerhard Dekan; Harald Renz; Christof Ebner; Rudolf Valenta; Dietrich Kraft
Intranasal treatment with a recombinant hypoallergenic derivative of the major birch pollen allergen Bet v 1 prevents allergic sensitization and airway inflammation in mice.
International archives of allergy and immunology 2001;126(1):68-77.
2001: Susanne Vrtala; Kora Hirtenlehner; Markus Susani; Mübeccel Akdis; Fatimah Kussebi; Cezmi A. Akdis; Kurt Blaser; Peter Hufnagl; Bernd R Binder; A Politou; A Pastore; Luca Vangelista; Wolfgang R Sperr; Hans Semper; Peter Valent; Christof Ebner; Dietrich Kraft; Rudolf Valenta
Genetic engineering of a hypoallergenic trimer of the major birch pollen allergen Bet v 1.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2001;15(11):2045-7.
2001: Monika Grote; Susanne Vrtala; Verena Niederberger; Rolf Wiermann; Rudolf Valenta; Rudolf Reichelt
Release of allergen-bearing cytoplasm from hydrated pollen: a mechanism common to a variety of grass (Poaceae) species revealed by electron microscopy.
The Journal of allergy and clinical immunology 2001;108(1):109-15.
2001: Ursula Wiedermann; Udo Herz; Susanne Vrtala; Ulrich Neuhaus-Steinmetz; Harald Renz; Christof Ebner; Rudolf Valenta; Dietrich Kraft
Mucosal tolerance induction with hypoallergenic molecules in a murine model of allergic asthma.
International archives of allergy and immunology 2001;124(1-3):391-4.
2000: Susanne Vrtala; Cezmi A. Akdis; F Budak; Mübeccel Akdis; Kurt Blaser; Dietrich Kraft; Rudolf Valenta
T cell epitope-containing hypoallergenic recombinant fragments of the major birch pollen allergen, Bet v 1, induce blocking antibodies.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(11):6653-9.
2000: Sabine Flicker; Susanne Vrtala; Peter Steinberger; Luca Vangelista; A Bufe; A Petersen; Minoo Ghannadan; Wolfgang R Sperr; Peter Valent; L Norderhaug; Barbara Bohle; Hannes Stockinger; C Suphioglu; E K Ong; Dietrich Kraft; Rudolf Valenta
A human monoclonal IgE antibody defines a highly allergenic fragment of the major timothy grass pollen allergen, Phl p 5: molecular, immunological, and structural characterization of the epitope-containing domain.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(7):3849-59.
2000: Gabrielle Pauli; Ashok Purohit; JP Oster; Frédéric de Blay; Susanne Vrtala; Verena Niederberger; D Kraft; Rudolf Valenta
Comparison of genetically engineered hypoallergenic rBet v 1 derivatives with rBet v 1 wild-type by skin prick and intradermal testing: results obtained in a French population.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2000;30(8):1076-84.
2000: Anna Nopp; Gunilla Halldén; Joachim Lundahl; Eva Johansson; Susanne Vrtala; Rudolf Valenta; Reidar Grönneberg; Marianne Van Hage-Hamsten
Comparison of inflammatory responses to genetically engineered hypoallergenic derivatives of the major birch pollen allergen bet v 1 and to recombinant bet v 1 wild type in skin chamber fluids collected from birch pollen-allergic patients.
The Journal of allergy and clinical immunology 2000;106(1 Pt 1):101-9.
2000: Monika Grote; Susanne Vrtala; Verena Niederberger; Rudolf Valenta; Rudolf Reichelt
Expulsion of allergen-containing materials from hydrated rye grass (Lolium perenne) pollen revealed by using immunogold field emission scanning and transmission electron microscopy.
The Journal of allergy and clinical immunology 2000;105(6 Pt 1):1140-5.
2000: R Aghayan-Ugurluoglu; Tanja Ball; Susanne Vrtala; C Schweiger; Dietrich Kraft; Rudolf Valenta
Dissociation of allergen-specific IgE and IgA responses in sera and tears of pollen-allergic patients: a study performed with purified recombinant pollen allergens.
The Journal of allergy and clinical immunology 2000;105(4):803-13.
1999: Susanne Vrtala; S Fischer; Monika Grote; Luca Vangelista; A Pastore; Wolfgang R Sperr; Peter Valent; Rudolf Reichelt; Dietrich Kraft; Rudolf Valenta
Molecular, immunological, and structural characterization of Phl p 6, a major allergen and P-particle-associated protein from Timothy grass (Phleum pratense) pollen.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(10):5489-96.
1999: Marianne Van Hage-Hamsten; Marianne Kronqvist; Olle Zetterström; Eva Johansson; Verena Niederberger; Susanne Vrtala; Hans Grönlund; Reidar Grönneberg; Rudolf Valenta
Skin test evaluation of genetically engineered hypoallergenic derivatives of the major birch pollen allergen, Bet v 1: results obtained with a mix of two recombinant Bet v 1 fragments and recombinant Bet v 1 trimer in a Swedish population before the birch pollen season.
The Journal of allergy and clinical immunology 1999;104(5):969-77.
1999: B Pandjaitan; Petra Eibensteiner; Susanne Vrtala; Brigitte Hayek; Monika Grote; Rudolf Reichelt; Helmut Rumpold; Rudolf Valenta; Susanne Spitzauer
pET-prof, a plasmid for high-level expression of recombinant peptides fused to a birch profilin-derived hexadecapeptide tag: a system for the detection and presentation of recombinant antigens.
Gene 1999;237(2):333-42.
1999: S De Marino; M A Morelli; Franca Fraternali; E Tamborini; Giovanna Musco; Susanne Vrtala; C Dolecek; paolo arosio; Rudolf Valenta; Annalisa Pastore
An immunoglobulin-like fold in a major plant allergen: the solution structure of Phl p 2 from timothy grass pollen.
Structure (London, England : 1993) 1999;7(8):943-52.
1999: Rudolf Valenta; Susanne Vrtala; Margarete Focke-Tejkl; Tanja Ball; Anna Twardosz; Susanne Spitzauer; Hans Grönlund; Dietrich Kraft
Genetically engineered and synthetic allergen derivatives: candidates for vaccination against type I allergy.
Biological chemistry 1999;380(7-8):815-24.
1999: Verena Niederberger; Brigitte Hayek; Susanne Vrtala; Sylvia Laffer; Anna Twardosz; Luca Vangelista; Wolfgang R Sperr; Peter Valent; Helmut Rumpold; Dietrich Kraft; Klaus Ehrenberger; Rudolf Valenta; Susanne Spitzauer
Calcium-dependent immunoglobulin E recognition of the apo- and calcium-bound form of a cross-reactive two EF-hand timothy grass pollen allergen, Phl p 7.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1999;13(8):843-56.
1999: Susanne Vrtala; Kora Hirtenlehner; Markus Susani; Peter Hufnagl; Bernd R Binder; Luca Vangelista; A Pastore; Wolfgang R Sperr; Peter Valent; Christof Ebner; Dietrich Kraft; Rudolf Valenta
Genetic engineering of recombinant hypoallergenic oligomers of the major birch pollen allergen, Bet v 1: candidates for specific immunotherapy.
International archives of allergy and immunology 1999;118(2-4):218-9.
1999: Gabrielle Pauli; Ashok Purohit; JP Oster; Frédéric de Blay; Susanne Vrtala; Verena Niederberger; D Kraft; Rudolf Valenta
Clinical evaluation of genetically engineered hypoallergenic rBet v 1 derivatives.
International archives of allergy and immunology 1999;118(2-4):216-7.
1999: Dietrich Kraft; Fatima Ferreira; Susanne Vrtala; Heimo Breiteneder; Christof Ebner; Rudolf Valenta; Markus Susani; M Breitenbach; Otto Scheiner
The importance of recombinant allergens for diagnosis and therapy of IgE-mediated allergies.
International archives of allergy and immunology 1999;118(2-4):171-6.
1999: Rudolf Valenta; Anna Twardosz; Susanne Vrtala; Dietrich Kraft
Large scale production and quality criteria of recombinant allergens.
Arbeiten aus dem Paul-Ehrlich-Institut (Bundesamt für Sera und Impfstoffe) zu Frankfurt a.M 1999;(93):211-24; discussion 224-5.
1999: Gabrielle Pauli; Ashok Purohit; JP Oster; Frédéric de Blay; Susanne Vrtala; Verena Niederberger; D Kraft; Rudolf Valenta
Skin testing with wild-type recombinant birch pollen allergens and hypoallergenic modified molecules.
Arbeiten aus dem Paul-Ehrlich-Institut (Bundesamt für Sera und Impfstoffe) zu Frankfurt a.M 1999;(93):203-10.
1998: Brigitte Hayek; Luca Vangelista; A Pastore; Wolfgang R Sperr; Peter Valent; Susanne Vrtala; Verena Niederberger; Anna Twardosz; Dietrich Kraft; Rudolf Valenta
Molecular and immunologic characterization of a highly cross-reactive two EF-hand calcium-binding alder pollen allergen, Aln g 4: structural basis for calcium-modulated IgE recognition.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(12):7031-9.
1998: Rudolf Valenta; Steven C Almo; Tanja Ball; C Dolecek; Peter Steinberger; Sylvia Laffer; Petra Eibensteiner; Sabine Flicker; Susanne Vrtala; Susanne Spitzauer; Peter Valent; S Denepoux; Dietrich Kraft; Jacques Banchereau; Serge Lebecque
The immunoglobulin E-allergen interaction: a target for therapy of type I allergic diseases.
International archives of allergy and immunology 1998;116(3):167-76.
1998: Susanne Vrtala; Tanja Ball; Susanne Spitzauer; B Pandjaitan; C Suphioglu; B Knox; Wolfgang R Sperr; Peter Valent; Dietrich Kraft; Rudolf Valenta
Immunization with purified natural and recombinant allergens induces mouse IgG1 antibodies that recognize similar epitopes as human IgE and inhibit the human IgE-allergen interaction and allergen-induced basophil degranulation.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(12):6137-44.
1998: Rudolf Valenta; Susanne Vrtala; Sylvia Laffer; Susanne Spitzauer; Dietrich Kraft
Recombinant allergens.
Allergy 1998;53(6):552-61.
1997: Susanne Vrtala; Kora Hirtenlehner; Luca Vangelista; A Pastore; H G Eichler; Wolfgang R Sperr; Peter Valent; Christof Ebner; Dietrich Kraft; Rudolf Valenta
Division of the major birch pollen allergen, Bet v 1, into two non-anaphylactic fragments.
International archives of allergy and immunology 1997;113(1-3):246-8.
1997: Susanne Vrtala; Kora Hirtenlehner; Luca Vangelista; A Pastore; H G Eichler; Wolfgang R Sperr; Peter Valent; Christof Ebner; Dietrich Kraft; Rudolf Valenta
Conversion of the major birch pollen allergen, Bet v 1, into two nonanaphylactic T cell epitope-containing fragments: candidates for a novel form of specific immunotherapy.
The Journal of clinical investigation 1997;99(7):1673-81.
1996: Susanne Vrtala; P Mayer; Fatima Ferreira; M Susani; A H Sehon; Dietrich Kraft; Rudolf Valenta
Induction of IgE antibodies in mice and rhesus monkeys with recombinant birch pollen allergens: different allergenicity of Bet v 1 and Bet v 2.
The Journal of allergy and clinical immunology 1996;98(5 Pt 1):913-21.
1996: Susanne Vrtala; P Wiedemann; I Mittermann; H G Eichler; W R Sperr; Peter Valent; Dietrich Kraft; Rudolf Valenta
High-level expression in Escherichia coli and purification of recombinant plant profilins: comparison of IgE-binding capacity and allergenic activity.
Biochemical and biophysical research communications 1996;226(1):42-50.
1996: Susanne Vrtala; M Susani; W R Sperr; Peter Valent; Sylvia Laffer; C Dolecek; Dietrich Kraft; Rudolf Valenta
Immunologic characterization of purified recombinant timothy grass pollen (Phleum pratense) allergens (Phl p 1, Phl p2, Phl p 5).
The Journal of allergy and clinical immunology 1996;97(3):781-7.
1996: Rudolf Valenta; Sylvia Laffer; Susanne Vrtala; Hans Grönlund; Lena Elfman; W R Sperr; Peter Valent; Fatima Ferreira; P Mayer; E Liehl; S Heiss; R Steiner; Hans-Georg Eichler; M Susani; Dietrich Kraft
Recombinant allergens. Steps on the way to diagnosis and therapy of type I allergy.
Advances in experimental medicine and biology 1996;409():185-96.
1995: Susanne Vrtala; Monika Grote; Fatima Ferreira; M Susani; B Stocker; Dietrich Kraft; Rudolf Valenta
Humoral immune responses to recombinant tree pollen allergens (Bet v I and Bet v II) in mice: construction of a live oral allergy vaccine.
International archives of allergy and immunology 1995;107(1-3):290-4.
1994: Tanja Ball; Susanne Vrtala; W R Sperr; Peter Valent; M Susani; Dietrich Kraft; Rudolf Valenta
Isolation of an immunodominant IgE hapten from an epitope expression cDNA library. Dissection of the allergic effector reaction.
The Journal of biological chemistry 1994;269(45):28323-8.
1994: Sylvia Laffer; Rudolf Valenta; Susanne Vrtala; M Susani; R van Ree; Dietrich Kraft; Otto Scheiner; Michael Duchêne
Complementary DNA cloning of the major allergen Phl p I from timothy grass (Phleum pratense); recombinant Phl p I inhibits IgE binding to group I allergens from eight different grass species.
The Journal of allergy and clinical immunology 1994;94(4):689-98.
1994: Sylvia Laffer; Susanne Vrtala; Michael Duchêne; R van Ree; Dietrich Kraft; Otto Scheiner; Rudolf Valenta
IgE-binding capacity of recombinant timothy grass (Phleum pratense) pollen allergens.
The Journal of allergy and clinical immunology 1994;94(1):88-94.
1994: Rudolf Valenta; Tanja Ball; Susanne Vrtala; Michael Duchêne; Dietrich Kraft; Otto Scheiner
cDNA cloning and expression of timothy grass (Phleum pratense) pollen profilin in Escherichia coli: comparison with birch pollen profilin.
Biochemical and biophysical research communications 1994;199(1):106-18.
1994: Rudolf Valenta; Susanne Vrtala; Sylvia Laffer; Peter Steinberger; Tanja Ball; Fatima Ferreira; Otto Scheiner; Dietrich Kraft
B-cell epitopes of allergens determined by recombinant techniques; use for diagnosis and therapy of type I allergy.
Arbeiten aus dem Paul-Ehrlich-Institut (Bundesamt für Sera und Impfstoffe) zu Frankfurt a.M 1994;(87):235-46.
1993: C Dolecek; Susanne Vrtala; Sylvia Laffer; Peter Steinberger; Dietrich Kraft; Otto Scheiner; Rudolf Valenta
Molecular characterization of Phl p II, a major timothy grass (Phleum pratense) pollen allergen.
FEBS letters 1993;335(3):299-304.
1993: Susanne Vrtala; W R Sperr; I Reimitzer; R van Ree; Sylvia Laffer; WD Müller; Peter Valent; Klaus Lechner; Helmut Rumpold; Dietrich Kraft
cDNA cloning of a major allergen from timothy grass (Phleum pratense) pollen; characterization of the recombinant Phl pV allergen.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(9):4773-81.
1993: Rudolf Valenta; Fatima Ferreira; Monika Grote; I Swoboda; Susanne Vrtala; Michael Duchêne; P Deviller; Richard B Meagher; E McKinney; Erwin Heberle-Bors
Identification of profilin as an actin-binding protein in higher plants.
The Journal of biological chemistry 1993;268(30):22777-81.
1993: Monika Grote; Susanne Vrtala; Rudolf Valenta
Monitoring of two allergens, Bet v I and profilin, in dry and rehydrated birch pollen by immunogold electron microscopy and immunoblotting.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1993;41(5):745-50.
1993: Susanne Vrtala; Monika Grote; Michael Duchêne; R van Ree; Dietrich Kraft; Otto Scheiner; Rudolf Valenta
Properties of tree and grass pollen allergens: reinvestigation of the linkage between solubility and allergenicity.
International archives of allergy and immunology 1993;102(2):160-9.
1993: Rudolf Valenta; Peter Steinberger; Susanne Vrtala; Monika Grote; Sylvia Laffer; W R Sperr; Peter Valent; Dietrich Kraft; Otto Scheiner
[New concepts in therapy of type I allergic diseases].
Wiener klinische Wochenschrift 1993;105(23):682-6.
1992: Rudolf Valenta; Susanne Vrtala; Christof Ebner; Dietrich Kraft; Otto Scheiner
Diagnosis of grass pollen allergy with recombinant timothy grass (Phleum pratense) pollen allergens.
International archives of allergy and immunology 1992;97(4):287-94.
1991: Rudolf Valenta; M Duchene; Susanne Vrtala; T Birkner; Christof Ebner; R Hirschwehr; Michael Breitenbach; Helmut Rumpold; Otto Scheiner; Dietrich Kraft
Recombinant allergens for immunoblot diagnosis of tree-pollen allergy.
The Journal of allergy and clinical immunology 1991;88(6):889-94.