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Pia Vuorela

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Mohit Narwal; Pia Vuorela; Adyary Fallarero; Teemu Haikarainen; Lari Lehtiö
Screening and structural analysis of flavones inhibiting tankyrases.
Adyary Fallarero; Ulla-Mari Parkkisenniemi-Kinnunen; Katariina Pohjanoksa; Mika Scheinin; Gloria Wissel; Henri Xhaard; Pia Vuorela
High-throughput screening with a miniaturized radioligand competition assay identifies new modulators of human α2-adrenoceptors.
Gerda Brunhofer; Adyary Fallarero; C Gopi Mohan; Daniela Karlsson; Pravin Shinde; Ana Batista-Gonzalez; Pia Vuorela
Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.

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All Publications

2013: Mohit Narwal; Pia Vuorela; Adyary Fallarero; Teemu Haikarainen; Lari Lehtiö
Screening and structural analysis of flavones inhibiting tankyrases.
Journal of medicinal chemistry 2013;56(9):3507-17.
2012: Adyary Fallarero; Ulla-Mari Parkkisenniemi-Kinnunen; Katariina Pohjanoksa; Mika Scheinin; Gloria Wissel; Henri Xhaard; Pia Vuorela
High-throughput screening with a miniaturized radioligand competition assay identifies new modulators of human α2-adrenoceptors.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2012;47(5):941-51.
2012: Gerda Brunhofer; Adyary Fallarero; C Gopi Mohan; Daniela Karlsson; Pravin Shinde; Ana Batista-Gonzalez; Pia Vuorela
Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.
Bioorganic & medicinal chemistry 2012;20(22):6669-79.
2012: L L Pohjala; N K Sairio; Pia Vuorela
Interference by bovine serum albumin in PED6 based phospholipase A2 screening assays.
Die Pharmazie 2012;67(11):954-5.
2012: Natalja Genina; Edward Haeggström; Petri Ihalainen; Ivan Kassamakov; Jouko Peltonen; Leena Pohjala; Henrik Ehlers; Daniela Fors; Hossein Vakili; Pia Vuorela; Niklas Sandler
Tailoring controlled-release oral dosage forms by combining inkjet and flexographic printing techniques.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2012;47(3):615-23.
2012: Malena E Skogman; Pia Vuorela; Igor Busygin; Janni Kujala; Reko Leinob; Adyary Fallarero
Evaluation of antibacterial and anti-biofilm activities of cinchona alkaloid derivatives against Staphylococcus aureus.
Natural product communications 2012;7(9):1173-6.
2012: Malena Elise Skogman; Pia Vuorela; Adyary Fallarero
Combining biofilm matrix measurements with biomass and viability assays in susceptibility assessments of antimicrobials against Staphylococcus aureus biofilms.
The Journal of antibiotics 2012;65(9):453-9.
2012: Daniela Karlsson; Claudia Mayer; C Gopi Mohan; Ohm Prakash; Pia Vuorela; Gerda Brunhofer; Adyary Fallarero; Thomas Erker
The exploration of thienothiazines as selective butyrylcholinesterase inhibitors.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2012;47(1):190-205.
2012: Antti Siiskonen; Pia Vuorela; Leena Keurulainen; Paula Kiuru; Leena Pohjala; Olli Salin; Jari Yli-Kauhaluoma
Conformation study of 2-arylbenzimidazoles as inhibitors of Chlamydia pneumoniae growth.
Bioorganic & medicinal chemistry letters 2012;22(14):4882-6.
2012: Mohit Narwal; Pia Vuorela; Adyary Fallarero; Lari Lehtiö
Homogeneous screening assay for human tankyrase.
Journal of biomolecular screening 2012;17(5):593-604.
2012: Mirko Rossi; Pia Vuorela; Heidi Hyytiäinen; Sundus Javed; Joana Revez; Florian Anderl; Christian Bolz; Nahed El-Najjar; Markus Gerhard; Marja-Liisa Hänninen
Evidence for conserved function of γ-glutamyltranspeptidase in Helicobacter genus.
PloS one 2012;7(2):e30543.
2011: Olli P Salin; Heikki Vuorela; Maija Leinonen; Leena L Pohjala; Pekka Saikku; Pia Vuorela
Effects of coadministration of natural polyphenols with doxycycline or calcium modulators on acute Chlamydia pneumoniae infection in vitro.
The Journal of antibiotics 2011;64(11):747-52.
2011: Mari Hämäläinen; Riina Nieminen; Heikki Vapaatalo; Pia Vuorela; M Zaini Asmawi; Eeva Moilanen
Effects of flavonoids on prostaglandin E2 production and on COX-2 and mPGES-1 expressions in activated macrophages.
Planta medica 2011;77(13):1504-11.
2011: Emilia Varhimo; Pekka Varmanen; Adyary Fallarero; Malena Skogman; Satu Pyörälä; Antti Iivanainen; Antti Sukura; Pia Vuorela; Kirsi Savijoki
Alpha- and β-casein components of host milk induce biofilm formation in the mastitis bacterium Streptococcus uberis.
Veterinary microbiology 2011;149(3-4):381-9.
2011: Satu Koskela; Päivi P Söderholm; Miia Ainasoja; Tero Wennberg; Karel D Klika; Vladimir V Ovcharenko; Irene Kylänlahti; Tiina Auerma; Jari Yli-Kauhaluoma; Kalevi Pihlaja; Pia Vuorela; Teemu H Teeri
Polyketide derivatives active against Botrytis cinerea in Gerbera hybrida.
Planta 2011;233(1):37-48.
2011: Päivi Järvinen; Pia Vuorela; Annele Hatakka; Adyary Fallarero
Potency determinations of acetylcholinesterase inhibitors using Ellman's reaction-based assay in screening: Effect of assay variants.
Analytical biochemistry 2011;408(1):166-8.
2010: Leena Keurulainen; Olli Salin; Antti Siiskonen; Jan Marco Kern; Joni Alvesalo; Paula Kiuru; Matthias Maass; Jari Yli-Kauhaluoma; Pia Vuorela
Design and synthesis of 2-arylbenzimidazoles and evaluation of their inhibitory effect against Chlamydia pneumoniae.
Journal of medicinal chemistry 2010;53(21):7664-74.
2010: Olli Salin; Sami Alakurtti; Leena Pohjala; Antti Siiskonen; Viola Maass; Matthias Maass; Jari Yli-Kauhaluoma; Pia Vuorela
Inhibitory effect of the natural product betulin and its derivatives against the intracellular bacterium Chlamydia pneumoniae.
Biochemical pharmacology 2010;80(8):1141-51.
2010: Vildan Alptüzün; Michaela Prinz; Verena Hörr; Josef Scheiber; Krzysztof Radacki; Adyary Fallarero; Pia Vuorela; Bernd Engels; Holger Braunschweig; Ercin Erciyas; Ulrike Holzgrabe
Interaction of (benzylidene-hydrazono)-1,4-dihydropyridines with beta-amyloid, acetylcholine, and butyrylcholine esterases.
Bioorganic & medicinal chemistry 2010;18(5):2049-59.
2010: Laura H Riihimäki-Lampén; Mikko J Vainio; Mikko Vahermo; Leena L Pohjala; Jonna M S Heikura; Kaija H Valkonen; Vesa Virtanen; Jari Yli-Kauhaluoma; Pia Vuorela
The binding of synthetic retinoids to lipocalin beta-lactoglobulins.
Journal of medicinal chemistry 2010;53(1):514-8.
2009: Anna Galkin; Adyary Fallarero; Pia Vuorela
Coumarins permeability in Caco-2 cell model.
The Journal of pharmacy and pharmacology 2009;61(2):177-84.
2009: Anna Galkin; Jouni Jokela; Matti Wahlsten; Päivi Tammela; Kaarina Sivonen; Pia Vuorela
Discovering protein kinase C active plants growing in Finland utilizing automated bioassay combined to LC/MS.
Natural product communications 2009;4(1):139-42.
2009: Sabiruddin Mirza; Inna Miroshnyk; Jyrki Heinämäki; Osmo Antikainen; Jukka Rantanen; Pia Vuorela; Heikki Vuorela; Jouko Yliruusi
Crystal morphology engineering of pharmaceutical solids: tabletting performance enhancement.
AAPS PharmSciTech 2009;10(1):113-9.
2008: Kirsi Savijoki; Joni Alvesalo; Pia Vuorela; Maija Leinonen; Nisse Kalkkinen
Proteomic analysis of Chlamydia pneumoniae-infected HL cells reveals extensive degradation of cytoskeletal proteins.
FEMS immunology and medical microbiology 2008;54(3):375-84.
2008: Laura H Riihimäki; Mikko J Vainio; Jonna M S Heikura; Kaija H Valkonen; Vesa Virtanen; Pia Vuorela
Binding of phenolic compounds and their derivatives to bovine and reindeer beta-lactoglobulin.
Journal of agricultural and food chemistry 2008;56(17):7721-9.
2008: Jie Chen; Adyary Fallarero; Anni Määttänen; Malena Sandberg; Jouko Peltonen; Pia Vuorela; Marja-Liisa Riekkola
Living cells of Staphylococcus aureus immobilized onto the capillary surface in electrochromatography: a tool for screening of biofilms.
Analytical chemistry 2008;80(13):5103-9.
2008: Anna Galkin; Jukka S Pakkanen; Pia Vuorela
Development of an automated 7-day 96-well Caco-2 cell culture model.
Die Pharmazie 2008;63(6):464-9.
2008: Laura Riihimäki; Anna Galkin; Moshe Finel; Jonna Heikura; Kaija H Valkonen; Vesa Virtanen; Reijo Laaksonen; J Peter Slotte; Pia Vuorela
Transport properties of bovine and reindeer beta-lactoglobulin in the Caco-2 cell model.
International journal of pharmaceutics 2008;347(1-2):1-8.
2008: Joni Alvesalo; Dario Greco; Maija Leinonen; Tuomas Raitila; Pia Vuorela; Petri Auvinen
Microarray analysis of a Chlamydia pneumoniae-infected human epithelial cell line by use of gene ontology hierarchy.
The Journal of infectious diseases 2008;197(1):156-62.
2007: Pia Vuorela; Sirpa Ala-Mello; Carola Saloranta; Maila Penttinen; Minna Pöyhönen; Kirsi Huoponen; Wiktor Borozdin; Birke Bausch; Elke M Botzenhart; Christian Wilhelm; Helena Kääriäinen; Juergen Kohlhase
Molecular analysis of the CHD7 gene in CHARGE syndrome: identification of 22 novel mutations and evidence for a low contribution of large CHD7 deletions.
Genetics in medicine : official journal of the American College of Medical Genetics 2007;9(10):690-4.
2007: Leena Laitinen; Elina Takala; Heikki Vuorela; Pia Vuorela; Ann Marie Kaukonen; Martti Marvola
Anthranoid laxatives influence the absorption of poorly permeable drugs in human intestinal cell culture model (Caco-2).
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 2007;66(1):135-45.
2007: Leena Pohjala; Päivi Tammela; SWAPAN SAMANTA; Jari Yli-Kauhaluoma; Pia Vuorela
Assessing the data quality in predictive toxicology using a panel of cell lines and cytotoxicity assays.
Analytical biochemistry 2007;362(2):221-8.
2007: Mari Hämäläinen; Riina Nieminen; Pia Vuorela; Mari L Heinonen; Eeva Moilanen
Anti-inflammatory effects of flavonoids: genistein, kaempferol, quercetin, and daidzein inhibit STAT-1 and NF-kappaB activations, whereas flavone, isorhamnetin, naringenin, and pelargonidin inhibit only NF-kappaB activation along with their inhibitory effect on iNOS expression and NO production in activated macrophages.
Mediators of inflammation 2007;2007():45673.
2006: Kari Kreander; Anna Galkin; Satu Vuorela; Päivi Tammela; Leena Laitinen; Marina Heinonen; Pia Vuorela
In-vitro mutagenic potential and effect on permeability of co-administered drugs across Caco-2 cell monolayers of Rubus idaeus and its fortified fractions.
The Journal of pharmacy and pharmacology 2006;58(11):1545-52.
2006: Päivi P Oinonen; Jouni K Jokela; Annele I Hatakka; Pia Vuorela
Linarin, a selective acetylcholinesterase inhibitor from Mentha arvensis.
Fitoterapia 2006;77(6):429-34.
2006: Laura Riihimäki; Olli Aitio; Mikko Vahermo; Jonna Heikura; Kaija H Valkonen; Vesa Virtanen; Jari Yli-Kauhaluoma; Pia Vuorela
Microplate screening assay for binding of ligands to bovine or reindeer beta-lactoglobulins.
Journal of biochemical and biophysical methods 2006;68(2):75-85.
2006: Pia Fyhrquist; L Mwasumbi; Pia Vuorela; Heikki Vuorela; Raimo Hiltunen; C Murphy; H Adlercreutz
Preliminary antiproliferative effects of some species of Terminalia, Combretum and Pteleopsis collected in Tanzania on some human cancer cell lines.
Fitoterapia 2006;77(5):358-66.
2006: Joni Alvesalo; Antti Siiskonen; Mikko J Vainio; Päivi Tammela; Pia Vuorela
Similarity based virtual screening: a tool for targeted library design.
Journal of medicinal chemistry 2006;49(7):2353-6.
2006: Joni Alvesalo; Heikki Vuorela; Päivi Tammela; M Leinonen; Pekka Saikku; Pia Vuorela
Inhibitory effect of dietary phenolic compounds on Chlamydia pneumoniae in cell cultures.
Biochemical pharmacology 2006;71(6):735-41.
2006: Kari Kreander; Mika Kurkela; Antti Siiskonen; Pia Vuorela; Päivi Tammela
Identification of COMT and ErmC inhibitors by using a microplate assay in combination with library focusing by virtual screening.
Die Pharmazie 2006;61(3):247-8.
2006: Adyary Fallarero; A Peltoketo; Jarkko Loikkanen; Päivi Tammela; Alexis Vidal; Pia Vuorela
Effects of the aqueous extract of Bryothamnion triquetrum on chemical hypoxia and aglycemia-induced damage in GT1-7 mouse hypothalamic immortalized cells.
Phytomedicine : international journal of phytotherapy and phytopharmacology 2006;13(4):240-5.
2005: Liisa Törmäkangas; Pia Vuorela; Elise Saario; Maija Leinonen; Pekka Saikku; Heikki Vuorela
In vivo treatment of acute Chlamydia pneumoniae infection with the flavonoids quercetin and luteolin and an alkyl gallate, octyl gallate, in a mouse model.
Biochemical pharmacology 2005;70(8):1222-30.
2005: Satu Vuorela; Kari Kreander; Maarit Karonen; Riina Nieminen; Mari Hämäläinen; Anna Galkin; Leena Laitinen; Juha-Pekka Salminen; Eeva Moilanen; Kalevi Pihlaja; Heikki Vuorela; Pia Vuorela; Marina Heinonen
Preclinical evaluation of rapeseed, raspberry, and pine bark phenolics for health related effects.
Journal of agricultural and food chemistry 2005;53(15):5922-31.
2005: Anu Surakka; Leila Sihvonen; Jaana M Lehtimäki; Matti Wahlsten; Pia Vuorela; Kaarina Sivonen
Benthic cyanobacteria from the Baltic Sea contain cytotoxic Anabaena, Nodularia, and Nostoc strains and an apoptosis-inducing Phormidium strain.
Environmental toxicology 2005;20(3):285-92.
2005: Kari Kreander; Pia Vuorela; Päivi Tammela
A rapid screening method for detecting active compounds against erythromycin-resistant bacterial strains of Finnish origin.
Folia microbiologica 2005;50(6):487-93.
2004: Leena Laitinen; Päivi Tammela; Anna Galkin; Heikki Vuorela; Martti L A Marvola; Pia Vuorela
Effects of extracts of commonly consumed food supplements and food fractions on the permeability of drugs across Caco-2 cell monolayers.
Pharmaceutical research 2004;21(10):1904-16.
2004: Päivi Tammela; Joni Alvesalo; Laura Riihimäki; Sari Airenne; Maija Leinonen; Pertti Hurskainen; Kristian Enkvist; Pia Vuorela
Development and validation of a time-resolved fluorometric immunoassay for screening of antichlamydial activity using a genus-specific europium-conjugated antibody.
Analytical biochemistry 2004;333(1):39-48.
2004: Päivi Tammela; Tero Wennberg; Heikki Vuorela; Pia Vuorela
HPLC micro-fractionation coupled to a cell-based assay for automated on-line primary screening of calcium antagonistic components in plant extracts.
Analytical and bioanalytical chemistry 2004;380(4):614-8.
2004: Mika Kurkela; Antti Siiskonen; Moshe Finel; Päivi Tammela; Jyrki Taskinen; Pia Vuorela
Microplate screening assay to identify inhibitors of human catechol-O-methyltransferase.
Analytical biochemistry 2004;331(1):198-200.
2004: Päivi Tammela; Pia Vuorela
Miniaturisation and validation of a cell-based assay for screening of Ca2+ channel modulators.
Journal of biochemical and biophysical methods 2004;59(3):229-39.
2004: Päivi Tammela; Leena Laitinen; Anna Galkin; Tero Wennberg; Robert Heczko; Heikki Vuorela; J Peter Slotte; Pia Vuorela
Permeability characteristics and membrane affinity of flavonoids and alkyl gallates in Caco-2 cells and in phospholipid vesicles.
Archives of biochemistry and biophysics 2004;425(2):193-9.
2004: Manu Eeva; Jussi-Pekka Rauha; Pia Vuorela; Heikki Vuorela
Computer-assisted, high-performance liquid chromatography with mass spectrometric detection for the analysis of coumarins in Peucedanum palustre and Angelica archangelica.
Phytochemical analysis : PCA 2004;15(3):167-74.
2004: Samo Andrensek; Breda Simonovska; Irena Vovk; Pia Fyhrquist; Heikki Vuorela; Pia Vuorela
Antimicrobial and antioxidative enrichment of oak (Quercus robur) bark by rotation planar extraction using ExtraChrom.
International journal of food microbiology 2004;92(2):181-7.
2003: Alexis Vidal; Adyary Fallarero; Blanca R Peña; Maria E Medina; Bienvenido Gra; Felicia Rivera; Yamilet Gutierrez; Pia Vuorela
Studies on the toxicity of Punica granatum L. (Punicaceae) whole fruit extracts.
Journal of ethnopharmacology 2003;89(2-3):295-300.
2003: Elina L Jääskeläinen; Vera V Teplova; Maria A Andersson; Leif C Andersson; Päivi Tammela; Magnus Andersson; Tuula Pirhonen; Nils-Erik L Saris; Pia Vuorela; Mirja S Salkinoja-Salonen
In vitro assay for human toxicity of cereulide, the emetic mitochondrial toxin produced by food poisoning Bacillus cereus.
Toxicology in vitro : an international journal published in association with BIBRA 2003;17(5-6):737-44.
2003: Irena Vovk; Breda Simonovska; Samo Andrensek; Heikki Vuorela; Pia Vuorela
Rotation planar extraction and rotation planar chromatography of oak (Quercus robur L.) bark.
Journal of chromatography. A 2003;991(2):267-74.
2002: Teijo Yrjönen; Pia Vuorela; Karel D Klika; Kalevi Pihlaja; Teemu H Teeri; Heikki Vuorela
Application of centrifugal force to the extraction and separation of parasorboside and gerberin from Gerbera hybrida.
Phytochemical analysis : PCA 2002;13(6):349-53.
2002: Fredrik Ollila; Katrin K Halling; Pia Vuorela; Heikki Vuorela; J Peter Slotte
Characterization of flavonoid--biomembrane interactions.
Archives of biochemistry and biophysics 2002;399(1):103-8.
2002: Pia Fyhrquist; L Mwasumbi; C-A Haeggström; Heikki Vuorela; Raimo Hiltunen; Pia Vuorela
Ethnobotanical and antimicrobial investigation on some species of Terminalia and Combretum (Combretaceae) growing in Tanzania.
Journal of ethnopharmacology 2002;79(2):169-77.
2001: J P Haansuu; Karel D Klika; P P Söderholm; Vladimir V Ovcharenko; Kalevi Pihlaja; KK Haahtela; Pia Vuorela
Isolation and biological activity of frankiamide.
Journal of industrial microbiology & biotechnology 2001;27(1):62-6.
2001: Karel D Klika; J P Haansuu; Vladimir V Ovcharenko; KK Haahtela; Pia Vuorela; Kalevi Pihlaja
Frankiamide, a highly unusual macrocycle containing the imide and orthoamide functionalities from the symbiotic actinomycete Frankia.
The Journal of organic chemistry 2001;66(11):4065-8.
2001: T Ojala; Pia Vuorela; Heikki Vuorela; Kid Törnquist
The coumarin osthol attenuates the binding of thyrotropin-releasing hormone in rat pituitary GH4C1 cells.
Planta medica 2001;67(3):236-9.
2001: Jari Summanen; Pia Vuorela; Jussi-Pekka Rauha; Päivi Tammela; K Marjamäki; Michael Pasternack; Kid Törnquist; Heikki Vuorela
Effects of simple aromatic compounds and flavonoids on Ca2+ fluxes in rat pituitary GH(4)C(1) cells.
European journal of pharmacology 2001;414(2-3):125-33.
2000: T Ojala; S Remes; P Haansuu; Heikki Vuorela; Raimo Hiltunen; KK Haahtela; Pia Vuorela
Antimicrobial activity of some coumarin containing herbal plants growing in Finland.
Journal of ethnopharmacology 2000;73(1-2):299-305.
2000: Jussi-Pekka Rauha; S Remes; Marina Heinonen; Anu Hopia; Marja P Kähkönen; T Kujala; Kalevi Pihlaja; Heikki Vuorela; Pia Vuorela
Antimicrobial effects of Finnish plant extracts containing flavonoids and other phenolic compounds.
International journal of food microbiology 2000;56(1):3-12.
1999: T Ojala; Pia Vuorela; J Kiviranta; Heikki Vuorela; Raimo Hiltunen
A bioassay using Artemia salina for detecting phototoxicity of plant coumarins.
Planta medica 1999;65(8):715-8.
1998: K Outinen; Heikki Haario; Pia Vuorela; M Nyman; Esko Ukkonen; Heikki Vuorela
Optimization of selectivity in high-performance liquid chromatography using desirability functions and mixture designs according to PRISMA.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 1998;6(3):197-205.
1998: Ann Marie Kaukonen; Pia Vuorela; Heikki Vuorela; Jukka-Pekka Mannermaa
High-performance liquid chromatography methods for the separation and quantitation of spironolactone and its degradation products in aqueous formulations and of its metabolites in rat serum.
Journal of chromatography. A 1998;797(1-2):271-81.
1997: H R Liang; Pia Vuorela; Heikki Vuorela; Raimo Hiltunen
Isolation and immunomodulatory effect of flavonol glycosides from Epimedium hunanense.
Planta medica 1997;63(4):316-9.
1997: H Vuorela; Pia Vuorela; K Törnquist; S Alaranta
Calcium channel blocking activity: Screening methods for plant derived compounds.
Phytomedicine : international journal of phytotherapy and phytopharmacology 1997;4(2):167-80.
1995: K Outinen; Pia Vuorela; R Hinkkanen; Raimo Hiltunen; Heikki Vuorela
Optimization of the HPLC analysis of biogenic amines in Peucedanum palustre plants and cell culture lines.
Planta medica 1995;61(3):259-63.
1994: O Mousa; Pia Vuorela; J Kiviranta; S A Wahab; Raimo Hiltunen; Heikki Vuorela
Bioactivity of certain Egyptian Ficus species.
Journal of ethnopharmacology 1994;41(1-2):71-6.
1993: J Mäenpää; Holger H Sigusch; Hannu Raunio; T Syngelmä; Pia Vuorela; Heikki Vuorela; Olavi Pelkonen
Differential inhibition of coumarin 7-hydroxylase activity in mouse and human liver microsomes.
Biochemical pharmacology 1993;45(5):1035-42.