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Viktor Brabec
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40
Kasparkova, Jana
23
Kaspárková, Jana
22
Vrána, Oldrich
21
Farrell, Nicholas
19
Nováková, Olga
16
Natile, Giovanni
15
Malina, Jaroslav
14
Novakova, Olga
13
Sadler, Peter
9
Gibson, Dan
8
Balcarová, Z
8
Najajreh, Yousef
8
Marini, Victoria
7
Hofr, Ctirad
7
Vrana, Oldrich
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All Publications
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2010: Zerzankova Lenka; Suchankova Tereza; Vrana Oldrich; Farrell Nicholas P; Brabec Viktor; Kasparkova Jana
Conformation and recognition of DNA modified by a new antitumor dinuclear PtII complex resistant to decomposition by sulfur nucleophiles.
Biochemical pharmacology 2010;79(2):112-21.
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2009: Malina Jaroslav; Vrana Oldrich; Brabec Viktor
Mechanistic studies of the modulation of cleavage activity of topoisomerase I by DNA adducts of mono- and bi-functional PtII complexes.
Nucleic acids research 2009;37(16):5432-42.
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2009: Heringova Pavla; Kasparkova Jana; Brabec Viktor
DNA adducts of antitumor cisplatin preclude telomeric sequences from forming G quadruplexes.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2009;14(6):959-68.
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2009: Nováková Olga; Malina Jaroslav; Kaspárková Jana; Halámiková Anna; Bernard Vladan; Intini Francesco; Natile Giovanni; Brabec Viktor
Energetics, conformation, and recognition of DNA duplexes modified by methylated analogues of [PtCl(dien)]+.
Chemistry (Weinheim an der Bergstrasse, Germany) 2009;15(25):6211-21.
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2009: Nováková Olga; Nazarov Alexey A; Hartinger Christian G; Keppler Bernhard K; Brabec Viktor
DNA interactions of dinuclear RuII arene antitumor complexes in cell-free media.
Biochemical pharmacology 2009;77(3):364-74.
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2009: Suchánková Tereza; Vojtísková Marie; Reedijk Jan; Brabec Viktor; Kaspárková Jana
DNA and glutathione interactions in cell-free media of asymmetric platinum(II) complexes cis- and trans-[PtCl2(isopropylamine)(1-methylimidazole)]: relations to their different antitumor effects.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2009;14(1):75-87.
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2008: Bugarcic Tijana; Habtemariam Abraha; Stepankova Jana; Heringova Pavla; Kasparkova Jana; Deeth Robert J; Johnstone Russell D L; Prescimone Alessandro; Parkin Andrew; Parsons Simon; Brabec Viktor; Sadler Peter J
The contrasting chemistry and cancer cell cytotoxicity of bipyridine and bipyridinediol ruthenium(II) arene complexes.
Inorganic chemistry 2008;47(24):11470-86.
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2008: Kasparkova Jana; Marini Victoria; Bursova Vendula; Brabec Viktor
Biophysical studies on the stability of DNA intrastrand cross-links of transplatin.
Biophysical journal 2008;95(9):4361-71.
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2008: Bugarcic Tijana; Nováková Olga; Halámiková Anna; Zerzánková Lenka; Vrána Oldrich; Kaspárková Jana; Habtemariam Abraha; Parsons Simon; Sadler Peter J; Brabec Viktor
Cytotoxicity, cellular uptake, and DNA interactions of new monodentate ruthenium(II) complexes containing terphenyl arenes.
Journal of medicinal chemistry 2008;51(17):5310-9.
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2008: Castellano-Castillo Maria; Kostrhunova Hana; Marini Victoria; Kasparkova Jana; Sadler Peter J; Malinge Jean-Marc; Brabec Viktor
Binding of mismatch repair protein MutS to mispaired DNA adducts of intercalating ruthenium(II) arene complexes.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2008;13(6):993-9.
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2008: Kostrhunova Hana; Florian Jakub; Novakova Olga; Peacock Anna F A; Sadler Peter J; Brabec Viktor
DNA interactions of monofunctional organometallic osmium(II) antitumor complexes in cell-free media.
Journal of medicinal chemistry 2008;51(12):3635-43.
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2008: Malina Jaroslav; Hannon Michael J; Brabec Viktor
DNA binding of dinuclear iron(II) metallosupramolecular cylinders. DNA unwinding and sequence preference.
Nucleic acids research 2008;36(11):3630-8.
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2008: Halámiková Anna; Heringová Pavla; Kaspárková Jana; Intini Francesco P; Natile Giovanni; Nemirovski Alina; Gibson Dan; Brabec Viktor
Cytotoxicity, mutagenicity, cellular uptake, DNA and glutathione interactions of lipophilic trans-platinum complexes tethered to 1-adamantylamine.
Journal of inorganic biochemistry 2008;102(5-6):1077-89.
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2008: Hegmans Alexander; Kasparkova Jana; Vrana Oldrich; Kelland Lloyd R; Brabec Viktor; Farrell Nicholas P
Amide-based prodrugs of spermidine-bridged dinuclear platinum. Synthesis, DNA binding, and biological activity.
Journal of medicinal chemistry 2008;51(7):2254-60.
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2008: de Mier-Vinué Jordi; Gay Marina; Montaña Angel M; Sáez Rosa-Isabel; Moreno Virtudes; Kasparkova Jana; Vrana Oldrich; Heringova Pavla; Brabec Viktor; Boccarelli Angela; Coluccia Mauro; Natile Giovanni
Synthesis, biophysical studies, and antiproliferative activity of platinum(II) complexes having 1,2-bis(aminomethyl)carbobicyclic ligands.
Journal of medicinal chemistry 2008;51(3):424-31.
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2008: Malina Jaroslav; Hannon Michael J; Brabec Viktor
Interaction of dinuclear ruthenium(II) supramolecular cylinders with DNA: sequence-specific binding, unwinding, and photocleavage.
Chemistry (Weinheim an der Bergstrasse, Germany) 2008;14(33):10408-14.
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2008: Kasparkova Jana; Vojtiskova Marie; Natile Giovanni; Brabec Viktor
Unique properties of DNA interstrand cross-links of antitumor oxaliplatin and the effect of chirality of the carrier ligand.
Chemistry (Weinheim an der Bergstrasse, Germany) 2008;14(4):1330-41.
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2007: Mackay Fiona S; Woods Julie A; Heringová Pavla; Kaspárková Jana; Pizarro Ana M; Moggach Stephen A; Parsons Simon; Brabec Viktor; Sadler Peter J
A potent cytotoxic photoactivated platinum complex.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(52):20743-8.
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2007: Malina Jaroslav; Novakova Olga; Vojtiskova Marie; Natile Giovanni; Brabec Viktor
Conformation of DNA GG intrastrand cross-link of antitumor oxaliplatin and its enantiomeric analog.
Biophysical journal 2007;93(11):3950-62.
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2007: Halamikova Anna; Vrana Oldrich; Kasparkova Jana; Brabec Viktor
Biochemical studies of the thermal effects on DNA modifications by the antitumor cisplatin and their repair.
Chembiochem : a European journal of chemical biology 2007;8(16):2008-15.
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2007: Melchart Michael; Habtemariam Abraha; Novakova Olga; Moggach Stephen A; Fabbiani Francesca P A; Parsons Simon; Brabec Viktor; Sadler Peter J
Bifunctional amine-tethered ruthenium(II) arene complexes form monofunctional adducts on DNA.
Inorganic chemistry 2007;46(21):8950-62.
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2007: Knipp Markus; Karotki Andrei V; Chesnov Serge; Natile Giovanni; Sadler Peter J; Brabec Viktor; Vasák Milan
Reaction of Zn7metallothionein with cis- and trans-[Pt(N-donor)2Cl2] anticancer complexes: trans-Pt(II) complexes retain their N-donor ligands.
Journal of medicinal chemistry 2007;50(17):4075-86.
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2007: Vrána Oldrich; Masek Vlastimil; Drazan Viktor; Brabec Viktor
Raman spectroscopy of DNA modified by intrastrand cross-links of antitumor cisplatin.
Journal of structural biology 2007;159(1):1-8.
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2007: Magennis Steven W; Habtemariam Abraha; Novakova Olga; Henry John B; Meier Samuel; Parsons Simon; Oswald Iain D H; Brabec Viktor; Sadler Peter J
Dual triggering of DNA binding and fluorescence via photoactivation of a dinuclear ruthenium(II) arene complex.
Inorganic chemistry 2007;46(12):5059-68.
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2007: Brabec Viktor; Christofis Petros; Slámová Martina; Kostrhunová Hana; Nováková Olga; Najajreh Yousef; Gibson Dan; Kaspárková Jana
DNA interactions of new cytotoxic tetrafunctional dinuclear platinum complex trans,trans-[{PtCl2(NH3)}2(piperazine)].
Biochemical pharmacology 2007;73(12):1887-900.
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2007: Gallmeier Eike; Hucl Tomas; Brody Jonathan R; Dezentje David A; Tahir Khola; Kasparkova Jana; Brabec Viktor; Bachman Kurtis E; Kern Scott E
High-throughput screening identifies novel agents eliciting hypersensitivity in Fanconi pathway-deficient cancer cells.
Cancer research 2007;67(5):2169-77.
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2007: Moriarity Branden; Nováková Olga; Farrell Nicholas; Brabec Viktor; Kaspárková Jana
1,2-GG intrastrand cross-link of antitumor dinuclear bifunctional platinum compound with spermidine linker inhibits DNA polymerization more effectively than the cross-link of conventional cisplatin.
Archives of biochemistry and biophysics 2007;459(2):264-72.
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2007: Malina Jaroslav; Hannon Michael J; Brabec Viktor
Recognition of DNA three-way junctions by metallosupramolecular cylinders: gel electrophoresis studies.
Chemistry (Weinheim an der Bergstrasse, Germany) 2007;13(14):3871-7.
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2007: Chválová Katerina; Brabec Viktor; Kaspárková Jana
Mechanism of the formation of DNA-protein cross-links by antitumor cisplatin.
Nucleic acids research 2007;35(6):1812-21.
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2006: Heringova Pavla; Woods Julie; Mackay Fiona S; Kasparkova Jana; Sadler Peter J; Brabec Viktor
Transplatin is cytotoxic when photoactivated: enhanced formation of DNA cross-links.
Journal of medicinal chemistry 2006;49(26):7792-8.
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2006: Kaspárková Jana; Nováková Olga; Vrána Oldrich; Intini Francesco; Natile Giovanni; Brabec Viktor
Molecular aspects of antitumor effects of a new platinum(IV) drug.
Molecular pharmacology 2006;70(5):1708-19.
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2006: Chválová Katerina; Kaspárková Jana; Farrell Nicholas; Brabec Viktor
Deoxyribonuclease I footprinting reveals different DNA binding modes of bifunctional platinum complexes.
The FEBS journal 2006;273(15):3467-78.
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2006: Najajreh Yousef; Ardeli-Tzaraf Yael; Kasparkova Jana; Heringova Pavla; Prilutski Dmitri; Balter Liliana; Jawbry Seba; Khazanov Elena; Perez Jose Manuel; Barenholz Yechezkel; Brabec Viktor; Gibson Dan
Interactions of platinum complexes containing cationic, bicyclic, nonplanar piperidinopiperidine ligands with biological nucleophiles.
Journal of medicinal chemistry 2006;49(15):4674-83.
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2006: Najajreh Yousef; Khazanov Elena; Jawbry Seba; Ardeli-Tzaraf Yael; Perez Jose Manuel; Kasparkova Jana; Brabec Viktor; Barenholz Yechezkel; Gibson Dan
Cationic nonsymmetric transplatinum complexes with piperidinopiperidine ligands. Preparation, characterization, in vitro cytotoxicity, in vivo toxicity, and anticancer efficacy studies.
Journal of medicinal chemistry 2006;49(15):4665-73.
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2006: Brabec Viktor; Nováková Olga
DNA binding mode of ruthenium complexes and relationship to tumor cell toxicity.
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2006;9(3):111-22.
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2006: Ramos-Lima Francisco J; Vrána Oldrich; Quiroga Adoración G; Navarro-Ranninger Carmen; Halámiková Anna; Rybnícková Hana; Hejmalová Lenka; Brabec Viktor
Structural characterization, DNA interactions, and cytotoxicity of new transplatin analogues containing one aliphatic and one planar heterocyclic amine ligand.
Journal of medicinal chemistry 2006;49(8):2640-51.
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2006: Brabec Viktor; Stehlíková Kristýna; Malina Jaroslav; Vojtiísková Marie; Kaspárková Jana
Thermodynamic properties of damaged DNA and its recognition by xeroderma pigmentosum group A protein and replication protein A.
Archives of biochemistry and biophysics 2006;446(1):1-10.
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2006: Stehlíková Kristýna; Kaspárková Jana; Nováková Olga; Martínez Alberto; Moreno Virtudes; Brabec Viktor
Recognition of DNA modified by trans-[PtClNH(4-hydroxymethylpyridine)] by tumor suppressor protein p53 and character of DNA adducts of this cytotoxic complex.
The FEBS journal 2006;273(2):301-14.
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2006: Pivonková Hana; Brázdová Marie; Kaspárková Jana; Brabec Viktor; Fojta Miroslav
Recognition of cisplatin-damaged DNA by p53 protein: critical role of the p53 C-terminal domain.
Biochemical and biophysical research communications 2006;339(2):477-84.
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2005: Najajreh Yousef; Kasparkova Jana; Marini Victoria; Gibson Dan; Brabec Viktor
Structural characterization and DNA interactions of new cytotoxic transplatin analogues containing one planar and one nonplanar heterocyclic amine ligand.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2005;10(7):722-31.
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2005: Malina Jaroslav; Vojtiskova Marie; Brabec Viktor; Diakos Connie I; Hambley Trevor W
DNA adducts of the enantiomers of the Pt(II) complexes of the ahaz ligand (ahaz=3-aminohexahydroazepine) and recognition of these adducts by HMG domain proteins.
Biochemical and biophysical research communications 2005;332(4):1034-41.
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2005: Brabec Viktor; Kasparkova Jana
Modifications of DNA by platinum complexes. Relation to resistance of tumors to platinum antitumor drugs.
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2005;8(3):131-46.
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2005: Delalande Olivier; Malina Jaroslav; Brabec Viktor; Kozelka Jirí
Chiral differentiation of DNA adducts formed by enantiomeric analogues of antitumor cisplatin is sequence-dependent.
Biophysical journal 2005;88(6):4159-69.
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2005: Najajreh Yousef; Prilutski Dmitri; Ardeli-Tzaraf Yael; Perez Jose Manuel; Khazanov Elena; Barenholz Yechezkel; Kasparkova Jana; Brabec Viktor; Gibson Dan
Structure and unique interactions with DNA of a cationic trans-platinum complex with the nonplanar bicyclic piperidinopiperidine ligand.
Angewandte Chemie (International ed. in English) 2005;44(19):2885-7.
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2005: Hofr Ctirad; Brabec Viktor
Thermal stability and energetics of 15-mer DNA duplex interstrand crosslinked by trans-diamminedichloroplatinum(II).
Biopolymers 2005;77(4):222-9.
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2005: Bursova Vendula; Kasparkova Jana; Hofr Ctirad; Brabec Viktor
Effects of monofunctional adducts of platinum(II) complexes on thermodynamic stability and energetics of DNA duplexes.
Biophysical journal 2005;88(2):1207-14.
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2005: Novakova Olga; Kasparkova Jana; Bursova Vendula; Hofr Ctirad; Vojtiskova Marie; Chen Haimei; Sadler Peter J; Brabec Viktor
Conformation of DNA modified by monofunctional Ru(II) arene complexes: recognition by DNA binding proteins and repair. Relationship to cytotoxicity.
Chemistry & biology 2005;12(1):121-9.
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2005: Marini Victoria; Christofis Petros; Novakova Olga; Kasparkova Jana; Farrell Nicholas; Brabec Viktor
Conformation, protein recognition and repair of DNA interstrand and intrastrand cross-links of antitumor trans-[PtCl2(NH3)(thiazole)].
Nucleic acids research 2005;33(18):5819-28.
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2004: Kasparkova Jana; Vrana Oldrich; Farrell Nicholas; Brabec Viktor
Effect of the geometry of the central coordination sphere in antitumor trinuclear platinum complexes on DNA binding.
Journal of inorganic biochemistry 2004;98(10):1560-9.
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2004: Kloster Miriam; Kostrhunova Hana; Zaludova Renata; Malina Jaroslav; Kasparkova Jana; Brabec Viktor; Farrell Nicholas
Trifunctional dinuclear platinum complexes as DNA-protein cross-linking agents.
Biochemistry 2004;43(24):7776-86.
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2004: Prokop Radim; Kasparkova Jana; Novakova Olga; Marini Victoria; Pizarro Ana María; Navarro-Ranninger Carmen; Brabec Viktor
DNA interactions of new antitumor platinum complexes with trans geometry activated by a 2-metylbutylamine or sec-butylamine ligand.
Biochemical pharmacology 2004;67(6):1097-109.
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2004: Kasparkova Jana; Fojta Miroslav; Farrell Nicholas; Brabec Viktor
Differential recognition by the tumor suppressor protein p53 of DNA modified by the novel antitumor trinuclear platinum drug BBR3464 and cisplatin.
Nucleic acids research 2004;32(18):5546-52.
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2003: Chen Haimei; Parkinson John A; Nováková Olga; Bella Juraj; Wang Fuyi; Dawson Alice; Gould Robert; Parsons Simon; Brabec Viktor; Sadler Peter J
Induced-fit recognition of DNA by organometallic complexes with dynamic stereogenic centers.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(25):14623-8.
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2003: Kasparkova Jana; Novakova Olga; Najajreh Yousef; Gibson Dan; Perez Jose-Manuel; Brabec Viktor
Effects of a piperidine ligand on DNA modification by antitumor cisplatin analogues.
Chemical research in toxicology 2003;16(11):1424-32.
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2003: Novakova Olga; Kasparkova Jana; Malina Jaroslav; Natile Giovanni; Brabec Viktor
DNA-protein cross-linking by trans-[PtCl(2)(E-iminoether)(2)]. A concept for activation of the trans geometry in platinum antitumor complexes.
Nucleic acids research 2003;31(22):6450-60.
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2003: Kasparkova Jana; Novakova Olga; Marini Victoria; Najajreh Yousef; Gibson Dan; Perez Jose-Manuel; Brabec Viktor
Activation of trans geometry in bifunctional mononuclear platinum complexes by a piperidine ligand. Mechanistic studies on antitumor action.
The Journal of biological chemistry 2003;278(48):47516-25.
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2003: Novakova Olga; Chen Haimei; Vrana Oldrich; Rodger Alison; Sadler Peter J; Brabec Viktor
DNA interactions of monofunctional organometallic ruthenium(II) antitumor complexes in cell-free media.
Biochemistry 2003;42(39):11544-54.
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2003: Kaspárková Jana; Mackay Fiona S; Brabec Viktor; Sadler Peter J
Formation of platinated GG cross-links on DNA by photoactivation of a platinum(IV) azide complex.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2003;8(7):741-5.
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2003: Kasparkova Jana; Marini Victoria; Najajreh Yousef; Gibson Dan; Brabec Viktor
DNA binding mode of the cis and trans geometries of new antitumor nonclassical platinum complexes containing piperidine, piperazine, or 4-picoline ligand in cell-free media. Relations to their activity in cancer cell lines.
Biochemistry 2003;42(20):6321-32.
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2003: Fojta Miroslav; Pivonkova Hana; Brazdova Marie; Kovarova Lucie; Palecek Emil; Pospisilova Sarka; Vojtesek Borivoj; Kasparkova Jana; Brabec Viktor
Recognition of DNA modified by antitumor cisplatin by "latent" and "active" protein p53.
Biochemical pharmacology 2003;65(8):1305-16.
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2003: Kasparkova Jana; Delalande Olivier; Stros Michal; Elizondo-Riojas Miguel-Angel; Vojtiskova Marie; Kozelka Jiri; Brabec Viktor
Recognition of DNA interstrand cross-link of antitumor cisplatin by HMGB1 protein.
Biochemistry 2003;42(5):1234-44.
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2003: Kasparkova Jana; Novakova Olga; Farrell Nicholas; Brabec Viktor
DNA binding by antitumor trans-[PtCl2(NH3)(thiazole)]. Protein recognition and nucleotide excision repair of monofunctional adducts.
Biochemistry 2003;42(3):792-800.
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2002: Kasparkova Jana; Zehnulova Jana; Farrell Nicholas; Brabec Viktor
DNA interstrand cross-links of the novel antitumor trinuclear platinum complex BBR3464. Conformation, recognition by high mobility group domain proteins, and nucleotide excision repair.
The Journal of biological chemistry 2002;277(50):48076-86.
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2002: Benedetti Michele; Malina Jaroslav; Kasparkova Jana; Brabec Viktor; Natile Giovanni
Chiral discrimination in platinum anticancer drugs.
Environmental health perspectives 2002;110 Suppl 5():779-82.
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2002: Vrana Oldrich; Brabec Viktor
L-methionine inhibits reaction of DNA with anticancer cis-diamminedichloroplatinum(II).
Biochemistry 2002;41(36):10994-9.
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2002: Marini Victoria; Kasparkova Jana; Novakova Olga; Monsú Scolaro Luigi; Romeo Raffaello; Brabec Viktor
Biophysical analysis of natural, double-helical DNA modified by a dinuclear platinum(II) organometallic compound in a cell-free medium.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2002;7(7-8):725-34.
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2002: Brabec Viktor; Kasparkova Jana
Molecular aspects of resistance to antitumor platinum drugs.
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2002;5(3-4):147-61.
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2002: Stehlikova Kristyna; Kostrhunova Hana; Kasparkova Jana; Brabec Viktor
DNA bending and unwinding due to the major 1,2-GG intrastrand cross-link formed by antitumor cis-diamminedichloroplatinum(II) are flanking-base independent.
Nucleic acids research 2002;30(13):2894-8.
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2002: Janovská Eva; Nováková Olga; Natile Giovanni; Brabec Viktor
Differential genotoxic effects of antitumor trans-[PtCl(2)(E-iminoether)(2)] and cisplatin in Escherichia coli.
Journal of inorganic biochemistry 2002;90(3-4):155-8.
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2002: Malina Jaroslav; Kasparkova Jana; Natile Giovanni; Brabec Viktor
Recognition of major DNA adducts of enantiomeric cisplatin analogs by HMG box proteins and nucleotide excision repair of these adducts.
Chemistry & biology 2002;9(5):629-38.
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2002: McGregor Tracey D; Hegmans Alexander; Kaspárková Jana; Neplechová Kamila; Nováková Olga; Penazová Hana; Vrána Oldrich; Brabec Viktor; Farrell Nicholas
A comparison of DNA binding profiles of dinuclear platinum compounds with polyamine linkers and the trinuclear platinum phase II clinical agent BBR3464.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2002;7(4-5):397-404.
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2002: Brabec Viktor
DNA modifications by antitumor platinum and ruthenium compounds: their recognition and repair.
Progress in nucleic acid research and molecular biology 2002;71():1-68.
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2001: Missura M; Buterin T; Hindges R; Hübscher U; Kaspárková J; Brabec V; Naegeli H
Double-check probing of DNA bending and unwinding by XPA-RPA: an architectural function in DNA repair.
The EMBO journal 2001;20(13):3554-64.
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2001: Zehnulova J; Kasparkova J; Farrell N; Brabec V
Conformation, recognition by high mobility group domain proteins, and nucleotide excision repair of DNA intrastrand cross-links of novel antitumor trinuclear platinum complex BBR3464.
The Journal of biological chemistry 2001;276(25):22191-9.
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2001: Hofr C; Farrell N; Brabec V
Thermodynamic properties of duplex DNA containing a site-specific d(GpG) intrastrand crosslink formed by an antitumor dinuclear platinum complex.
Nucleic acids research 2001;29(10):2034-40.
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2001: Kasparkova J; Pospisilova S; Brabec V
Different recognition of DNA modified by aatitumor cisplatin and its clinically ineffective trans isomer by tumor suppressor protein p53.
The Journal of biological chemistry 2001;276(19):16064-9.
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2001: Malina J; Novakova O; Keppler B K; Alessio E; Brabec V
Biophysical analysis of natural, double-helical DNA modified by anticancer heterocyclic complexes of ruthenium(III) in cell-free media.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2001;6(4):435-45.
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2001: Hofr C; Brabec V
Thermal and thermodynamic properties of duplex DNA containing site-specific interstrand cross-link of antitumor cisplatin or its clinically ineffective trans isomer.
The Journal of biological chemistry 2001;276(13):9655-61.
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2000: Nováková O; Hofr C; Brabec V
Modification of natural, double-helical DNA by antitumor cis- and trans-[Cl(2)(Me(2)SO(4))(4)Ru] in cell-free media.
Biochemical pharmacology 2000;60(12):1761-71.
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2000: Kostrhunova H; Brabec V
Conformational analysis of site-specific DNA cross-links of cisplatin-distamycin conjugates.
Biochemistry 2000;39(41):12639-49.
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2000: Brabec V; Neplechova K; Kasparkova J; Farrell N
Steric control of DNA interstrand cross-link sites of trans platinum complexes: specificity can be dictated by planar nonleaving groups.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2000;5(3):364-8.
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2000: Kasparkova J; Farrell N; Brabec V
Sequence specificity, conformation, and recognition by HMG1 protein of major DNA interstrand cross-links of antitumor dinuclear platinum complexes.
The Journal of biological chemistry 2000;275(21):15789-98.
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2000: Malina J; Hofr C; Maresca L; Natile G; Brabec V
DNA interactions of antitumor cisplatin analogs containing enantiomeric amine ligands.
Biophysical journal 2000;78(4):2008-21.
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1999: Loskotová H; Brabec V
DNA interactions of cisplatin tethered to the DNA minor groove binder distamycin.
European journal of biochemistry / FEBS 1999;266(2):392-402.
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1999: McGregor T D; Balcarová Z; Qu Y; Tran M C; Zaludová R; Brabec V; Farrell N
Sequence-dependent conformational changes in DNA induced by polynuclear platinum complexes.
Journal of inorganic biochemistry 1999;77(1-2):43-6.
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1999: Kaspárková J; Nováková O; Vrána O; Farrell N; Brabec V
Effect of geometric isomerism in dinuclear platinum antitumor complexes on DNA interstrand cross-linking.
Biochemistry 1999;38(34):10997-1005.
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1999: Neplechová K; Kaspárková J; Vrána O; Nováková O; Habtemariam A; Watchman B; Sadler P J; Brabec V
DNA interactions of new antitumor aminophosphine platinum(II) complexes.
Molecular pharmacology 1999;56(1):20-30.
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1999: Brabec V; Kaspárková J; Vrána O; Nováková O; Cox J W; Qu Y; Farrell N
DNA modifications by a novel bifunctional trinuclear platinum phase I anticancer agent.
Biochemistry 1999;38(21):6781-90.
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1998: Zákovská A; Nováková O; Balcarová Z; Bierbach U; Farrell N; Brabec V
DNA interactions of antitumor trans-[PtCl2(NH3)(quinoline)].
European journal of biochemistry / FEBS 1998;254(3):547-57.
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1998: Balcarová Z; Kaspárková J; Zákovská A; Nováková O; Sivo M F; Natile G; Brabec V
DNA interactions of a novel platinum drug, cis-[PtCl(NH3)2(N7-acyclovir)]+.
Molecular pharmacology 1998;53(5):846-55.
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1997: Zaludová R; Zákovská A; Kaspárkova J; Balcarová Z; Vrána O; Coluccia M; Natile G; Brabec V
DNA modifications by antitumor trans-[PtCl2(E-iminoether)2].
Molecular pharmacology 1997;52(3):354-61.
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1997: Zaludová R; Zákovská A; Kasparková J; Balcarová Z; Kleinwächter V; Vrána O; Farrell N; Brabec V
DNA interactions of bifunctional dinuclear platinum(II) antitumor agents.
European journal of biochemistry / FEBS 1997;246(2):508-17.
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1997: Zaludová R; Natile G; Brabec V
The effect of antitumor trans-[PtCl2(E-iminoether)2] on B-->Z transition in DNA.
Anti-cancer drug design 1997;12(4):295-309.
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1996: Kaspárková J; Mellish K J; Qu Y; Brabec V; Farrell N
Site-specific d(GpG) intrastrand cross-links formed by dinuclear platinum complexes. Bending and NMR studies.
Biochemistry 1996;35(51):16705-13.
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1996: Vrána O; Boudný V; Brabec V
Superhelical torsion controls DNA interstrand cross-linking by antitumor cis- diamminedichloroplatinum(II).
Nucleic acids research 1996;24(20):3918-25.
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1996: Zaludová R; Kleinwächter V; Brabec V
The effect of ionic strength on melting of DNA modified by platinum(II) complexes.
Biophysical chemistry 1996;60(3):135-42.
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1996: Brabec V; Vrána O; Nováková O; Kleinwächter V; Intini F P; Coluccia M; Natile G
DNA adducts of antitumor trans-[PtCl2 (E-imino ether)2].
Nucleic acids research 1996;24(2):336-41.
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1995: Kaspárková J; Brabec V
Recognition of DNA interstrand cross-links of cis-diamminedichloroplatinum(II) and its trans isomer by DNA-binding proteins.
Biochemistry 1995;34(38):12379-87.
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1995: Nováková O; Kaspárková J; Vrána O; van Vliet P M; Reedijk J; Brabec V
Correlation between cytotoxicity and DNA binding of polypyridyl ruthenium complexes.
Biochemistry 1995;34(38):12369-78.
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1995: Nováková O; Vrána O; Kiseleva V I; Brabec V
DNA interactions of antitumor platinum(IV) complexes.
European journal of biochemistry / FEBS 1995;228(3):616-24.
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1994: Brabec V; Boudný V; Balcarová Z
Monofunctional adducts of platinum(II) produce in DNA a sequence-dependent local denaturation.
Biochemistry 1994;33(6):1316-22.
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1993: Brabec V; Balcarova Z
Restriction-enzyme cleavage of DNA modified by platinum(II) complexes.
European journal of biochemistry / FEBS 1993;216(1):183-7.
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1992: Balcarová Z; Mrázek J; Kleinwächter V; Brabec V
Cleavage by restriction enzymes of DNA modified with the antitumour drug cis-diamminedichloroplatinum(II).
General physiology and biophysics 1992;11(6):579-88.
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1992: Vrána O; Kiseleva V I; Poverenny A M; Brabec V
Conversion of DNA adducts of antitumour cis-diamminedichloroplatinum(II). Immunochemical analysis.
European journal of pharmacology 1992;226(1):5-13.
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1992: Boudný V; Vrána O; Gaucheron F; Kleinwachter V; Leng M; Brabec V
Biophysical analysis of DNA modified by 1,2-diaminocyclohexane platinum(II) complexes.
Nucleic acids research 1992;20(2):267-72.
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1991: Brabec V; Vrana O; Kiseleva V I; Poverenny A M
Polyclonal antibodies elicited against trans-diamminedichloroplatinum(II)-modified DNA and their application in nonradioactive hybridization experiments.
European journal of biochemistry / FEBS 1991;201(3):723-30.
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1991: Kogan E M; Dyatlova N G; Sidorova N S; Vilner L M; Vrána O; Brabec V
Biophysical studies of the complexes of polyriboguanylic acid with brominated and chlorinated polyribocytidylic acids.
Biophysical chemistry 1991;40(3):231-9.
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1991: Brabec V; Vrána O; Platonova G A; Kogan E M; Sidorova N S
Biophysical studies of the modification of poly(rG) . poly(rC) by cisplatin. Relations to the biological activity of the complex.
Chemico-biological interactions 1991;78(1):1-12.
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1990: Brabec V; Kleinwächter V; Butour J L; Johnson N P
Biophysical studies of the modification of DNA by antitumour platinum coordination complexes.
Biophysical chemistry 1990;35(2-3):129-41.
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1989: Balcarová Z; Brabec V
Reinterpretation of fluorescence of terbium ion-DNA complexes.
Biophysical chemistry 1989;33(1):55-61.
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1988: Brabec V; Vucelic D
Adsorption of human beta 2-microglobulin at a water/mercury interface.
Biophysical chemistry 1988;29(3):271-6.
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1987: Kasparová D; Vrána O; Kleinwächter V; Brabec V
The effect of platinum derivatives on interfacial properties of DNA.
Biophysical chemistry 1987;28(3):191-7.
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1986: Vrána O; Brabec V; Kleinwächter V
Polarographic studies on the conformation of some platinum complexes: relations to anti-tumour activity.
Anti-cancer drug design 1986;1(2):95-109.
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1984: Vrána O; Kleinwächter V; Brabec V
Polarographic activity of the antitumor drug cis-dichlorodiammineplatinum (II). The effect of hydrolysis and trans-isomerization of the drug.
Experientia 1984;40(5):446-51.
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1983: Vrána O; Kleinwächter V; Brabec V
Determination of platinum in urine by differential pulse polarography.
Talanta 1983;30(4):288-90.
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