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Thomas Brabletz

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Thomas Brabletz
EMT and MET in metastasis: where are the cancer stem cells?
Ulf D Kahlert; Donata Maciaczyk; Tomasz Bogiel; Thomas Brabletz; Soroush Doostkam; Charles G Eberhart; Gabriele Niedermann; Guido Nikkhah; Brent A Orr; Marco Prinz; Thomas Reithmeier; Jörg Schubert; Brian Simons; Jaroslaw Maciaczyk
Activation of canonical WNT/β-catenin signaling enhances in vitro motility of glioblastoma cells by activation of ZEB1 and other activators of epithelial-to-mesenchymal transition.
Aydan Bulut-Karslioglu; Inti Alberto de la Rosa-Velazquez; Borbala Gerle; Thomas Brabletz; Monika Lachner; Thomas Manke; Simone Meidhof; Susanne Opravil; Michaela Pagani; Valentina Perrera; Johannes Popow; Manuela Scaranaro; Nicholas Shukeir; Suzanne van de Nobelen; Thomas Jenuwein
A transcription factor-based mechanism for mouse heterochromatin formation.

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2012: Thomas Brabletz
EMT and MET in metastasis: where are the cancer stem cells?
Cancer cell 2012;22(6):699-701.
2012: Ulf D Kahlert; Donata Maciaczyk; Tomasz Bogiel; Thomas Brabletz; Soroush Doostkam; Charles G Eberhart; Gabriele Niedermann; Guido Nikkhah; Brent A Orr; Marco Prinz; Thomas Reithmeier; Jörg Schubert; Brian Simons; Jaroslaw Maciaczyk
Activation of canonical WNT/β-catenin signaling enhances in vitro motility of glioblastoma cells by activation of ZEB1 and other activators of epithelial-to-mesenchymal transition.
Cancer letters 2012;325(1):42-53.
2012: Aydan Bulut-Karslioglu; Inti Alberto de la Rosa-Velazquez; Borbala Gerle; Thomas Brabletz; Monika Lachner; Thomas Manke; Simone Meidhof; Susanne Opravil; Michaela Pagani; Valentina Perrera; Johannes Popow; Manuela Scaranaro; Nicholas Shukeir; Suzanne van de Nobelen; Thomas Jenuwein
A transcription factor-based mechanism for mouse heterochromatin formation.
Nature structural & molecular biology 2012;19(10):1023-30.
2012: Stefanie Jaitner; Thomas Brabletz; Hermann Herbst; Elke Hiendlmeyer; Thomas Kirchner; Jana A Reiche; Achim J Schäffauer; Andreas Jung
Human telomerase reverse transcriptase (hTERT) is a target gene of β-catenin in human colorectal tumors.
Cell cycle (Georgetown, Tex.) 2012;11(17):3331-8.
2012: Thomas Brabletz
To differentiate or not--routes towards metastasis.
Nature reviews. Cancer 2012;12(6):425-36.
2012: Thomas Brabletz
MiR-34 and SNAIL: another double-negative feedback loop controlling cellular plasticity/EMT governed by p53.
Cell cycle (Georgetown, Tex.) 2012;11(2):215-6.
2011: Tobias Keck; Thomas Brabletz
Under stress: p53 controls EMT and stemness in pancreatic epithelial cells.
Cell cycle (Georgetown, Tex.) 2011;10(11):1715.
2011: Jörg Schubert; Thomas Brabletz
p53 Spreads out further: suppression of EMT and stemness by activating miR-200c expression.
Cell research 2011;21(5):705-7.
2011: Zhishan Wang; Yong Zhao; Eric Smith; Gregory J Goodall; Paul A Drew; Thomas Brabletz; Chengfeng Yang
Reversal and prevention of arsenic-induced human bronchial epithelial cell malignant transformation by microRNA-200b.
Toxicological sciences : an official journal of the Society of Toxicology 2011;121(1):110-22.
2011: Simone Brabletz; Karolina Bajdak; Simone Meidhof; Ulrike Burk; Gabriele Niedermann; Elke Firat; Ulrich Wellner; Arno Dimmler; Gerhard Faller; Jörg Schubert; Thomas Brabletz
The ZEB1/miR-200 feedback loop controls Notch signalling in cancer cells.
The EMBO journal 2011;30(4):770-82.
2011: Nancy Gavert; Alessia Vivanti; John Hazin; Thomas Brabletz; Avri Ben-Ze'ev
L1-mediated colon cancer cell metastasis does not require changes in EMT and cancer stem cell markers.
Molecular cancer research : MCR 2011;9(1):14-24.
2010: Simone Brabletz; Thomas Brabletz
The ZEB/miR-200 feedback loop--a motor of cellular plasticity in development and cancer?
EMBO reports 2010;11(9):670-7.
2010: U F Wellner; Ulrich T Hopt; Thomas Brabletz
[Tumour stem cells and metastasis].
Zentralblatt für Chirurgie 2010;135(4):318-22.
2010: Nancy Gavert; Amir Ben-Shmuel; Vance Lemmon; Thomas Brabletz; Avri Ben-Ze'ev
Nuclear factor-kappaB signaling and ezrin are essential for L1-mediated metastasis of colon cancer cells.
Journal of cell science 2010;123(Pt 12):2135-43.
2010: Elizabeth Vincan; Dustin J Flanagan; Normand Pouliot; Thomas Brabletz; Simone Spaderna
Variable FZD7 expression in colorectal cancers indicates regulation by the tumour microenvironment.
Developmental dynamics : an official publication of the American Association of Anatomists 2010;239(1):311-7.
2009: Ulrich Wellner; Jörg Schubert; Ulrike C Burk; Otto Schmalhofer; Feng Zhu; Annika Sonntag; Bettina Waldvogel; Corinne Vannier; Douglas Darling; Axel zur Hausen; Valerie G Brunton; Jennifer Morton; Owen Sansom; Julia Schüler; Marc P Stemmler; Christoph Herzberger; Ulrich Hopt; Tobias Keck; Simone Brabletz; Thomas Brabletz
The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs.
Nature cell biology 2009;11(12):1487-95.
2009: David Horst; Jan Budczies; Thomas Brabletz; Thomas Kirchner; Falk Hlubek
Invasion associated up-regulation of nuclear factor kappaB target genes in colorectal cancer.
Cancer 2009;115(21):4946-58.
2009: Andreas Herbst; Bommer Guido; Lydia Kriegl; Andreas Jung; Andrea Behrens; Endy Csanadi; Markus Gerhard; Christian Bolz; Rainer Riesenberg; Wolfgang Zimmermann; Wolfgang Dietmaier; Isabella Wolf; Thomas Brabletz; Burkhard Göke; Frank T Kolligs
ITF-2 is disrupted via allelic loss of chromosome 18q21, and ITF-2B expression is lost at the adenoma-carcinoma transition.
Gastroenterology 2009;137(2):639-48, 648.e1-9.
2009: Otto Schmalhofer; Simone Brabletz; Thomas Brabletz
E-cadherin, beta-catenin, and ZEB1 in malignant progression of cancer.
Cancer metastasis reviews 2009;28(1-2):151-66.
2009: Simone Spaderna; Thomas Brabletz; Oliver G Opitz
The miR-200 family: central player for gain and loss of the epithelial phenotype.
Gastroenterology 2009;136(5):1835-7.
2009: Sebastian Baehs; Andreas Herbst; Susanne E Thieme; Claudia Perschl; Andrea Behrens; Silvio Scheel; Andreas Jung; Thomas Brabletz; Burkhard Göke; Helmut Blum; Frank T Kolligs
Dickkopf-4 is frequently down-regulated and inhibits growth of colorectal cancer cells.
Cancer letters 2009;276(2):152-9.
2009: Stella Wassermann; Silvio Scheel; Elke Hiendlmeyer; Richard Palmqvist; David Horst; Falk Hlubek; Angela Haynl; Lydia Kriegl; Simone Reu; Susanne Merkel; Thomas Brabletz; Thomas Kirchner; Andreas Jung
p16INK4a is a beta-catenin target gene and indicates low survival in human colorectal tumors.
Gastroenterology 2009;136(1):196-205.e2.
2008: Ulrike Burk; Jörg Schubert; Ulrich Wellner; Otto Schmalhofer; Elizabeth Vincan; Simone Spaderna; Thomas Brabletz
A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells.
EMBO reports 2008;9(6):582-9.
2008: Roland S Croner; Thomas Förtsch; Wolfgang M Brückl; Franz Rödel; Claus Rödel; Thomas Papadopoulos; Thomas Brabletz; Thomas Kirchner; Martin Sachs; Jürgen Behrens; Ludger Klein-Hitpass; Michael Stürzl; Werner Hohenberger; berthold lausen
Molecular signature for lymphatic metastasis in colorectal carcinomas.
Annals of surgery 2008;247(5):803-10.
2008: Simone Spaderna; Otto Schmalhofer; Mandy Wahlbuhl; Arno Dimmler; Katja Bauer; Aneesa Sultan; Falk Hlubek; Andreas Jung; Dennis Strand; Andreas Eger; Thomas Kirchner; Jürgen Behrens; Thomas Brabletz
The transcriptional repressor ZEB1 promotes metastasis and loss of cell polarity in cancer.
Cancer research 2008;68(2):537-44.
2008: Isabelle Gross; Isabelle Duluc; T Benameur; Alexandre Calon; Elisabeth Martin; Thomas Brabletz; Michèle Kedinger; Claire Domon-Dell; Jean-Noel Freund
The intestine-specific homeobox gene Cdx2 decreases mobility and antagonizes dissemination of colon cancer cells.
Oncogene 2008;27(1):107-15.
2007: Silke Lassmann; Laura H Tang; Marinela Capanu; Thomas Brabletz; Anja Schöpflin; Axel Zur Hausen; Mithat Gonen; Nancy Kemeny; Jinru Shia; David S Klimstra; Martin Werner
Predictive molecular markers for colorectal cancer patients with resected liver metastasis and adjuvant chemotherapy.
Gastroenterology 2007;133(6):1831-9.
2007: Falk Hlubek; Thomas Brabletz; Jan Budczies; Sabine Pfeiffer; Andreas Jung; Thomas Kirchner
Heterogeneous expression of Wnt/beta-catenin target genes within colorectal cancer.
International journal of cancer. Journal international du cancer 2007;121(9):1941-8.
2007: Kurt Aigner; Brigitta Dampier; L Descovich; Mario Mikula; A Sultan; Martin Schreiber; Wolfgang Mikulits; Thomas Brabletz; D Strand; P Obrist; Wolfgang Sommergruber; Norbert Schweifer; A Wernitznig; Hartmut Beug; Roland Foisner; Andreas Eger
The transcription factor ZEB1 (deltaEF1) promotes tumour cell dedifferentiation by repressing master regulators of epithelial polarity.
Oncogene 2007;26(49):6979-88.
2007: Nancy Gavert; Michal Sheffer; Shani Raveh; Simone Spaderna; Michael Shtutman; Thomas Brabletz; Francis Barany; Philip B Paty; Daniel A Notterman; Eytan Domany; Avri Ben-Ze'ev
Expression of L1-CAM and ADAM10 in human colon cancer cells induces metastasis.
Cancer research 2007;67(16):7703-12.
2007: Kurt Aigner; Luise Descovich; Mario Mikula; Aneesa Sultan; Brigitta Dampier; Stefan Bonné; Frans van Roy; Wolfgang Mikulits; Martin Schreiber; Thomas Brabletz; Wolfgang Sommergruber; Norbert Schweifer; Andreas Wernitznig; Hartmut Beug; Roland Foisner; Andreas Eger
The transcription factor ZEB1 (deltaEF1) represses Plakophilin 3 during human cancer progression.
FEBS letters 2007;581(8):1617-24.
2007: Elizabeth Vincan; Phillip K Darcy; C A Farrelly; Maree C Faux; Thomas Brabletz; Robert G Ramsay
Frizzled-7 dictates three-dimensional organization of colorectal cancer cell carcinoids.
Oncogene 2007;26(16):2340-52.
2007: Isabelle Coste; Jean-Noel Freund; Simone Spaderna; Thomas Brabletz; Toufic Renno
Precancerous lesions upon sporadic activation of beta-catenin in mice.
Gastroenterology 2007;132(4):1299-308.
2007: Riccardo Fodde; Thomas Brabletz
Wnt/beta-catenin signaling in cancer stemness and malignant behavior.
Current opinion in cell biology 2007;19(2):150-8.
2007: Clément Subtil; Eric Guérin; Anne Schneider; Marie-Pierre Chenard; Elisabeth Martin; Claire Domon-Dell; Isabelle Duluc; Thomas Brabletz; Michèle Kedinger; Bernard Duclos; Marie-Pierre Gaub; Jean-Noel Freund
Frequent rearrangements and amplification of the CDX2 homeobox gene in human sporadic colorectal cancers with chromosomal instability.
Cancer letters 2007;247(2):197-203.
2007: Fairouz Benahmed; Isabelle Gross; Dominique Guenot; Frédéric Jehan; Elisabeth Martin; Claire Domon-Dell; Thomas Brabletz; Michèle Kedinger; Jean-Noel Freund; Isabelle Duluc
The microenvironment controls CDX2 homeobox gene expression in colorectal cancer cells.
The American journal of pathology 2007;170(2):733-44.
2007: Elizabeth Vincan; Thomas Brabletz; Maree C Faux; Robert G Ramsay
A human three-dimensional cell line model allows the study of dynamic and reversible epithelial-mesenchymal and mesenchymal-epithelial transition that underpins colorectal carcinogenesis.
Cells, tissues, organs 2007;185(1-3):20-8.
2007: Elizabeth Vincan; Rajeeb Kumar Swain; Thomas Brabletz; Herbert Steinbeisser
Frizzled7 dictates embryonic morphogenesis: implications for colorectal cancer progression.
Frontiers in bioscience : a journal and virtual library 2007;12():4558-67.
2007: Thomas Brabletz
Frontiers in Cancer Prevention Research - Fifth Annual AACR Conference.
IDrugs : the investigational drugs journal 2007;10(1):20-2.
2007: Falk Hlubek; Simone Spaderna; Otto Schmalhofer; Andreas Jung; Thomas Kirchner; Thomas Brabletz
Wnt/FZD signaling and colorectal cancer morphogenesis.
Frontiers in bioscience : a journal and virtual library 2007;12():458-70.
2006: Thomas Waerner; Memetcan Alacakaptan; Ido Tamir; Rupert Oberauer; Annamaria Gal; Thomas Brabletz; Martin Schreiber; Martin Jechlinger; Hartmut Beug
ILEI: a cytokine essential for EMT, tumor formation, and late events in metastasis in epithelial cells.
Cancer cell 2006;10(3):227-39.
2006: Simone Spaderna; Otto Schmalhofer; Falk Hlubek; Geert Berx; Andreas Eger; Susanne Merkel; Andreas Jung; Thomas Kirchner; Thomas Brabletz
A transient, EMT-linked loss of basement membranes indicates metastasis and poor survival in colorectal cancer.
Gastroenterology 2006;131(3):830-40.
2006: Falk Hlubek; S Pfeiffer; Jan Budczies; Simone Spaderna; Andreas Jung; Thomas Kirchner; Thomas Brabletz
Securin (hPTTG1) expression is regulated by beta-catenin/TCF in human colorectal carcinoma.
British journal of cancer 2006;94(11):1672-7.
2006: Susanne Topf; Matthias Lüftl; Ulrich Neisius; Thomas Brabletz; Miklos Simon; Gerold Schuler; Erwin S Schultz
Mycosis fungoides palmaris et plantaris--an unusual variant of cutaneous T-cell lymphoma.
European journal of dermatology : EJD 2006;16(1):84-6.
2005: Katharina Beiter; Elke Hiendlmeyer; Thomas Brabletz; Falk Hlubek; Angela Haynl; Claudia Knoll; Thomas Kirchner; Andreas Jung
beta-Catenin regulates the expression of tenascin-C in human colorectal tumors.
Oncogene 2005;24(55):8200-4.
2005: Thomas Brabletz; Andreas Jung; Simone Spaderna; Falk Hlubek; Thomas Kirchner
Opinion: migrating cancer stem cells - an integrated concept of malignant tumour progression.
Nature reviews. Cancer 2005;5(9):744-9.
2005: Tilman Rau; Arno Dimmler; Manuela Häfner; Thomas Brabletz; Thomas Kirchner; Gerhard Faller
Aberrant expression of TTF-1 and forkhead factor HFH-4 in atrophic gastritis and ciliated metaplasia suggests gastric broncho-pulmonary transdetermination.
The Journal of pathology 2005;206(4):383-7.
2005: Roland S Croner; Andrea Peters; Wolfgang M Brueckl; Klaus E Matzel; Ludger Klein-Hitpass; Thomas Brabletz; Thomas Papadopoulos; Werner Hohenberger; Bertram Reingruber; berthold lausen
Microarray versus conventional prediction of lymph node metastasis in colorectal carcinoma.
Cancer 2005;104(2):395-404.
2005: Beate Liebig; Thomas Brabletz; Martin Staege; Jens Wulfänger; Dagmar Riemann; Stefan Burdach; Wolfgang G Ballhausen
Forced expression of deltaN-TCF-1B in colon cancer derived cell lines is accompanied by the induction of CEACAM5/6 and mesothelin.
Cancer letters 2005;223(1):159-67.
2005: Johan H van Es; Philippe Jay; Alex Gregorieff; Marielle E van Gijn; Suzanne Jonkheer; Pantelis Hatzis; Andrea Thiele; Maaike van den Born; Harry Begthel; Thomas Brabletz; Makoto M Taketo; Hans Clevers
Wnt signalling induces maturation of Paneth cells in intestinal crypts.
Nature cell biology 2005;7(4):381-6.
2005: Bommer Guido; Claudia Jäger; Eva-Maria Dürr; Sebastian Baehs; Sören Eichhorst; Thomas Brabletz; Gang Hu; Thomas Fröhlich; Georg Arnold; Dagmar C Kress; Burkhard Göke; Guido Bommer; Frank T Kolligs
DRO1, a gene down-regulated by oncogenes, mediates growth inhibition in colon and pancreatic cancer cells.
The Journal of biological chemistry 2005;280(9):7962-75.
2005: Nancy Gavert; Maralice Conacci-Sorrell; Daniela Gast; Annette Schneider; Peter Altevogt; Thomas Brabletz; Avri Ben-Ze'ev
L1, a novel target of beta-catenin signaling, transforms cells and is expressed at the invasive front of colon cancers.
The Journal of cell biology 2005;168(4):633-42.
2005: Konstanze Lenhard; Bommer Guido; Silke Asutay; Rolf Schauer; Thomas Brabletz; Burkhard Göke; Rolf Lamerz; Frank T Kolligs
Analysis of promoter methylation in stool: a novel method for the detection of colorectal cancer.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2005;3(2):142-9.
2005: Thomas Brabletz; Falk Hlubek; Simone Spaderna; Otto Schmalhofer; Elke Hiendlmeyer; Andreas Jung; Thomas Kirchner
Invasion and metastasis in colorectal cancer: epithelial-mesenchymal transition, mesenchymal-epithelial transition, stem cells and beta-catenin.
Cells, tissues, organs 2005;179(1-2):56-65.
2004: Maksim Yezhelyev; Gudrun Koehl; Markus Guba; Thomas Brabletz; Karl-Walter Jauch; Anderson Ryan; Alan Barge; Tim Green; Michael Fennell; Christiane J Bruns
Inhibition of SRC tyrosine kinase as treatment for human pancreatic cancer growing orthotopically in nude mice.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(23):8028-36.
2004: Thomas Brabletz; Simone Spaderna; Jochen Kolb; Falk Hlubek; Gerhard Faller; Christiane J Bruns; Andreas Jung; Jens Nentwich; Isabelle Duluc; Claire Domon-Dell; Thomas Kirchner; Jean-Noel Freund
Down-regulation of the homeodomain factor Cdx2 in colorectal cancer by collagen type I: an active role for the tumor environment in malignant tumor progression.
Cancer research 2004;64(19):6973-7.
2004: Gerhard Faller; Arno Dimmler; Tilman Rau; Simone Spaderna; Falk Hlubek; Andreas Jung; Thomas Kirchner; Thomas Brabletz
Evidence for acid-induced loss of Cdx2 expression in duodenal gastric metaplasia.
The Journal of pathology 2004;203(4):904-8.
2004: Elke Hiendlmeyer; Susanne Regus; Stella Wassermann; Falk Hlubek; Angela Haynl; Arno Dimmler; Claudia Koch; Claudia Knoll; Moniek van Beest; Ute Reuning; Thomas Brabletz; Thomas Kirchner; Andreas Jung
Beta-catenin up-regulates the expression of the urokinase plasminogen activator in human colorectal tumors.
Cancer research 2004;64(4):1209-14.
2004: Wolfgang M Brueckl; Elvira Heinze; Catrin Milsmann; Axel Wein; Corinna Koebnick; Andreas Jung; Roland S Croner; Thomas Brabletz; Klaus Günther; Thomas Kirchner; Eckhart Hahn; Werner Hohenberger; Heinz Becker; Bertram Reingruber
Prognostic significance of microsatellite instability in curatively resected adenocarcinoma of the small intestine.
Cancer letters 2004;203(2):181-90.
2004: Falk Hlubek; Simone Spaderna; Andreas Jung; Thomas Kirchner; Thomas Brabletz
Beta-catenin activates a coordinated expression of the proinvasive factors laminin-5 gamma2 chain and MT1-MMP in colorectal carcinomas.
International journal of cancer. Journal international du cancer 2004;108(2):321-6.
2004: Thomas Brabletz
In vivo functions of catenins.
Handbook of experimental pharmacology 2004;(165):105-35.
2004: Maike Buettner; Arno Dimmler; Achim Magener; Thomas Brabletz; Manfred Stolte; Thomas Kirchner; Gerhard Faller
Gastric PDX-1 expression in pancreatic metaplasia and endocrine cell hyperplasia in atrophic corpus gastritis.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2004;17(1):56-61.
2003: Arno Dimmler; Thomas Brabletz; Falk Hlubek; Manuela Häfner; Tilman Rau; Thomas Kirchner; Gerhard Faller
Transcription of sonic hedgehog, a potential factor for gastric morphogenesis and gastric mucosa maintenance, is up-regulated in acidic conditions.
Laboratory investigation; a journal of technical methods and pathology 2003;83(12):1829-37.
2003: Rina Rosin-Arbesfeld; Adam Cliffe; Thomas Brabletz; Mariann Bienz
Nuclear export of the APC tumour suppressor controls beta-catenin function in transcription.
The EMBO journal 2003;22(5):1101-13.
2003: Wolfgang M Brueckl; C Moesch; Thomas Brabletz; Corinna Koebnick; C Riedel; Andreas Jung; Susanne Merkel; Stefan Schaber; Frank Boxberger; Thomas Kirchner; Werner Hohenberger; Eckhart Hahn; Axel Wein
Relationship between microsatellite instability, response and survival in palliative patients with colorectal cancer undergoing first-line chemotherapy.
Anticancer research 2003;23(2C):1773-7.
2003: Thomas Brabletz; Thomas Kirchner
[Morphogenetic aspects of colorectal cancer].
Der Pathologe 2003;24(1):44-8.
2002: Nicole Reiche; Andreas Jung; Thomas Brabletz; Tanja Vater; Thomas Kirchner; Gerhard Faller
Generation and characterization of human monoclonal scFv antibodies against Helicobacter pylori antigens.
Infection and immunity 2002;70(8):4158-64.
2002: Thomas Brabletz; Andreas Jung; Thomas Kirchner
Beta-catenin and the morphogenesis of colorectal cancer.
Virchows Archiv : an international journal of pathology 2002;441(1):1-11.
2002: Stefan Ruckert; Elke Hiendlmeyer; Wolfgang M Brueckl; Ursula Oswald; Kurt Beyser; Wolfgang Dietmaier; Angela Haynl; Claudia Koch; Josef Rüschoff; Thomas Brabletz; Thomas Kirchner; Andreas Jung
T-cell factor-4 frameshift mutations occur frequently in human microsatellite instability-high colorectal carcinomas but do not contribute to carcinogenesis.
Cancer research 2002;62(11):3009-13.
2002: Andreas Jung; Stefan Ruckert; P Frank; Thomas Brabletz; Thomas Kirchner
7-Deaza-2'-deoxyguanosine allows PCR and sequencing reactions from CpG islands.
Molecular pathology : MP 2002;55(1):55-7.
2001: Falk Hlubek; Andreas Jung; N Kotzor; Thomas Kirchner; Thomas Brabletz
Expression of the invasion factor laminin gamma2 in colorectal carcinomas is regulated by beta-catenin.
Cancer research 2001;61(22):8089-93.
2001: Andreas Jung; M Schrauder; U Oswald; Claudia Knoll; P Sellberg; Richard Palmqvist; Gerald Niedobitek; Thomas Brabletz; Thomas Kirchner
The invasion front of human colorectal adenocarcinomas shows co-localization of nuclear beta-catenin, cyclin D1, and p16INK4A and is a region of low proliferation.
The American journal of pathology 2001;159(5):1613-7.
2001: Thomas Kirchner; S Müller; T Hattori; K Mukaisyo; Thomas Papadopoulos; Thomas Brabletz; Andreas Jung
Metaplasia, intraepithelial neoplasia and early cancer of the stomach are related to dedifferentiated epithelial cells defined by cytokeratin-7 expression in gastritis.
Virchows Archiv : an international journal of pathology 2001;439(4):512-22.
2001: Wolfgang M Brueckl; J M Preuss; Axel Wein; Andreas Jung; Thomas Brabletz; Rafael Pflüger; Gunther H Wiest; C Wolfl; Thomas Kirchner; Eckhart Hahn; Werner Hohenberger; Klaus Günther
Ki-67 expression and residual tumour (R) classification are associated with disease-free survival in desmoid tumour patients.
Anticancer research 2001;21(5):3615-20.
2001: Thomas Brabletz; Andreas Jung; S Reu; M Porzner; Falk Hlubek; L A Kunz-Schughart; R Knuechel; Thomas Kirchner
Variable beta-catenin expression in colorectal cancers indicates tumor progression driven by the tumor environment.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(18):10356-61.
2001: Falk Hlubek; C Löhberg; J Meiler; Andreas Jung; Thomas Kirchner; Thomas Brabletz
Tip60 is a cell-type-specific transcriptional regulator.
Journal of biochemistry 2001;129(4):635-41.
2001: Thomas Brabletz
[The Rudolf Virchow Prize 2001. The role of the oncoprotein beta-catenin ni the progression of colorectal cancers].
Verhandlungen der Deutschen Gesellschaft für Pathologie 2001;85():243-9.
2000: Wolfgang M Brueckl; T Limmert; Thomas Brabletz; Klaus Guenther; Andreas Jung; Kathrin Hermann; Gunther H Wiest; Thomas Kirchner; Werner Hohenberger; Eckhart Hahn; Axel Wein
Mismatch repair deficiency in sporadic synchronous colorectal cancer.
Anticancer research 2000;20(6C):4727-32.
2000: Thomas Kirchner; Thomas Brabletz
Patterning and nuclear beta-catenin expression in the colonic adenoma-carcinoma sequence. Analogies with embryonic gastrulation.
The American journal of pathology 2000;157(4):1113-21.
2000: Wolfgang M Brueckl; Andreas Jung; Axel Wein; Thomas Brabletz; Klaus Guenther; Gerhard Nusko; Eckhart Hahn
Microsatellite instability in colorectal adenomas: relevance and clinical importance.
International journal of colorectal disease 2000;15(4):189-96.
2000: Gerald Niedobitek; I Baumann; Thomas Brabletz; Renate Lisner; C Winkelmann; G Helm; Thomas Kirchner
Hodgkin's disease and peripheral T-cell lymphoma: composite lymphoma with evidence of Epstein-Barr virus infection.
The Journal of pathology 2000;191(4):394-9.
2000: Klaus Günther; Andreas Jung; U Völker; M Meyer; Thomas Brabletz; Klaus E Matzel; Marc A Reymond; T Kirchner; Werner Hohenberger
p27(kip1) expression in rectal cancer correlates with disease-free survival.
The Journal of surgical research 2000;92(1):78-84.
2000: Thomas Brabletz; K Herrmann; Andreas Jung; G Faller; Thomas Kirchner
Expression of nuclear beta-catenin and c-myc is correlated with tumor size but not with proliferative activity of colorectal adenomas.
The American journal of pathology 2000;156(3):865-70.
2000: Thomas Kirchner; Thomas Brabletz
Tumor patterning: analogies of neoplastic morphogenesis with embryogenesis.
Verhandlungen der Deutschen Gesellschaft für Pathologie 2000;84():22-7.
2000: Thomas Brabletz; Andreas Jung; S Dag; S Reu; Thomas Kirchner
[beta-Catenin induces invasive growth by activating matrix metalloproteinases in colorectal carcinoma].
Verhandlungen der Deutschen Gesellschaft für Pathologie 2000;84():175-81.
1999: Thomas Brabletz; Andreas Jung; S Dag; Falk Hlubek; Thomas Kirchner
beta-catenin regulates the expression of the matrix metalloproteinase-7 in human colorectal cancer.
The American journal of pathology 1999;155(4):1033-8.
1999: Thomas Brabletz; Andreas Jung; Falk Hlubek; C Löhberg; J Meiler; U Suchy; Thomas Kirchner
Negative regulation of CD4 expression in T cells by the transcriptional repressor ZEB.
International immunology 1999;11(10):1701-8.
1998: Klaus Günther; Thomas Brabletz; Cornelia Kraus; Otto Dworak; Marc A Reymond; A Jung; Werner Hohenberger; Thomas Kirchner; Ferdinand Köckerling; Wolfgang G Ballhausen
Predictive value of nuclear beta-catenin expression for the occurrence of distant metastases in rectal cancer.
Diseases of the colon and rectum 1998;41(10):1256-61.
1998: H Steininger; Gerhard Faller; E Dewald; Thomas Brabletz; Andreas Jung; Thomas Kirchner
Apoptosis in chronic gastritis and its correlation with antigastric autoantibodies.
Virchows Archiv : an international journal of pathology 1998;433(1):13-8.
1998: Klaus Günther; Thomas Brabletz; Otto Dworak; Marc A Reymond; Ferdinand Köckerling; Wolfgang G Ballhausen; Werner Hohenberger
[Beta-catenin expression and its significance for metastasis in curatively operated rectum carcinoma].
Langenbecks Archiv für Chirurgie. Supplement. Kongressband. Deutsche Gesellschaft für Chirurgie. Kongress 1998;115():1380-2.
1998: Thomas Brabletz; Andreas Jung; Kathrin Hermann; K Günther; Werner Hohenberger; Thomas Kirchner
Nuclear overexpression of the oncoprotein beta-catenin in colorectal cancer is localized predominantly at the invasion front.
Pathology, research and practice 1998;194(10):701-4.
1995: Jürgen C Becker; A Nikroo; Thomas Brabletz; Ralph A Reisfeld
DNA loops induced by cooperative binding of transcriptional activator proteins and preinitiation complexes.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(21):9727-31.
1995: Jürgen C Becker; Thomas Brabletz; Thomas Kirchner; C T Conrad; Eva-B Bröcker; Ralph A Reisfeld
Negative transcriptional regulation in anergic T cells.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(6):2375-8.
1994: I Pfeuffer; S Klein-Hessling; A Heinfling; Sergei Chuvpilo; C Escher; Thomas Brabletz; B Hentsch; H Schwarzenbach; Patrick Matthias; Edgar Serfling
Octamer factors exert a dual effect on the IL-2 and IL-4 promoters.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(12):5572-85.
1994: Stefan Gattenlöhner; Thomas Brabletz; A Schultz; Alexander Marx; Hans Konrad Müller-Hermelink; Thomas Kirchner
Cloning of a cDNA coding for the acetylcholine receptor alpha-subunit from a thymoma associated with myasthenia [correction of myastenia] gravis.
Thymus 1994;23(2):103-13.
1994: Alexander Marx; D Schömig; A Schultz; A Jung; Stefan Gattenlöhner; Thomas Brabletz; Thomas Kirchner; Hans Konrad Müller-Hermelink
[Thymus-like expression and molecules accessory to division and of thymocyte-stroma interactions in thymomas: a prerequisite for the establishment of an abnormal T-cell repertoire?].
Verhandlungen der Deutschen Gesellschaft für Pathologie 1994;78():270-6.
1993: Jürgen C Becker; Thomas Brabletz; C Czerny; C Termeer; Eva-B Bröcker
Tumor escape mechanisms from immunosurveillance: induction of unresponsiveness in a specific MHC-restricted CD4+ human T cell clone by the autologous MHC class II+ melanoma.
International immunology 1993;5(12):1501-8.
1993: Thomas Brabletz; I Pfeuffer; E Schorr; F Siebelt; Thomas Wirth; Edgar Serfling
Transforming growth factor beta and cyclosporin A inhibit the inducible activity of the interleukin-2 gene in T cells through a noncanonical octamer-binding site.
Molecular and cellular biology 1993;13(2):1155-62.
1991: Thomas Brabletz; I Pietrowski; Edgar Serfling
The immunosuppressives FK 506 and cyclosporin A inhibit the generation of protein factors binding to the two purine boxes of the interleukin 2 enhancer.
Nucleic acids research 1991;19(1):61-7.
1990: C Randak; Thomas Brabletz; M Hergenröther; I Sobotta; Edgar Serfling
Cyclosporin A suppresses the expression of the interleukin 2 gene by inhibiting the binding of lymphocyte-specific factors to the IL-2 enhancer.
The EMBO journal 1990;9(8):2529-36.