Renu Wadhwa

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Widodo Nashi; Shah Navjot; Priyandoko Didik; Ishii Tetsuro; Kaul Sunil C; Wadhwa Renu
Deceleration of senescence in normal human fibroblasts by withanone extracted from ashwagandha leaves.
Shah Navjot; Kataria Hardeep; Kaul Sunil C; Ishii Tetsuro; Kaur Gurcharan; Wadhwa Renu
Effect of the alcoholic extract of Ashwagandha leaves and its components on proliferation, migration, and differentiation of glioblastoma cells: combinational approach for enhanced differentiation.
Shiota Maki; Shamsur Lahman; Kawahara Shun-ichi; Wadhwa Renu; Ikeda Yutaka
Improvement of targeted gene delivery to human cancer cells by a novel trifunctional crosslinker.

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2009: Widodo Nashi; Shah Navjot; Priyandoko Didik; Ishii Tetsuro; Kaul Sunil C; Wadhwa Renu
Deceleration of senescence in normal human fibroblasts by withanone extracted from ashwagandha leaves.
The journals of gerontology. Series A, Biological sciences and medical sciences 2009;64(10):1031-8.
2009: Shah Navjot; Kataria Hardeep; Kaul Sunil C; Ishii Tetsuro; Kaur Gurcharan; Wadhwa Renu
Effect of the alcoholic extract of Ashwagandha leaves and its components on proliferation, migration, and differentiation of glioblastoma cells: combinational approach for enhanced differentiation.
Cancer science 2009;100(9):1740-7.
2009: Shiota Maki; Shamsur Lahman; Kawahara Shun-ichi; Wadhwa Renu; Ikeda Yutaka
Improvement of targeted gene delivery to human cancer cells by a novel trifunctional crosslinker.
Chemistry, an Asian journal 2009;4(8):1318-22.
2009: Ohyabu Yoshimi; Kaul Zeenia; Yoshioka Tomokazu; Inoue Kazuki; Sakai Shinsuke; Mishima Hajime; Uemura Toshimasa; Kaul Sunil C; Wadhwa Renu
Stable and nondisruptive in vitro/in vivo labeling of mesenchymal stem cells by internalizing quantum dots.
Human gene therapy 2009;20(3):217-24.
2009: Hasan Kamrul; Cheung Caroline; Kaul Zeenia; Shah Navjot; Sakaushi Shinji; Sugimoto Kenji; Oka Shigenori; Kaul Sunil C; Wadhwa Renu
CARF Is a vital dual regulator of cellular senescence and apoptosis.
The Journal of biological chemistry 2009;284(3):1664-72.
2009: Cheung Caroline T Y; Hasan Md Kamrul; Widodo Nashi; Kaul Sunil C; Wadhwa Renu
CARF: an emerging regulator of p53 tumor suppressor and senescence pathway.
Mechanisms of ageing and development 2009;130(1-2):18-23.
2009: Deocaris Custer C; Kaul Sunil C; Wadhwa Renu
The versatile stress protein mortalin as a chaperone therapeutic agent.
Protein and peptide letters 2009;16(5):517-29.
2008: Deocaris Custer C; Kaul Sunil C; Wadhwa Renu
From proliferative to neurological role of an hsp70 stress chaperone, mortalin.
Biogerontology 2008;9(6):391-403.
2008: Deocaris Custer C; Takano Syuichi; Priyandoko Didik; Kaul Zeenia; Yaguchi Tomoko; Kraft David C; Yamasaki Kazuhiko; Kaul Sunil C; Wadhwa Renu
Glycerol stimulates innate chaperoning, proteasomal and stress-resistance functions: implications for geronto-manipulation.
Biogerontology 2008;9(4):269-82.
2008: Hasan M Kamrul; Yaguchi Tomoko; Harada Jun Itadani; Hirano Takashi; Wadhwa Renu; Kaul Sunil C
CARF (collaborator of ARF) interacts with HDM2: evidence for a novel regulatory feedback regulation of CARF-p53-HDM2-p21WAF1 pathway.
International journal of oncology 2008;32(3):663-71.
2008: Deocaris Custer C; Widodo Nashi; Wadhwa Renu; Kaul Sunil C
Merger of ayurveda and tissue culture-based functional genomics: inspirations from systems biology.
Journal of translational medicine 2008;6():14.
2007: Deocaris Custer C; Widodo Nashi; Ishii Tetsuro; Kaul Sunil C; Wadhwa Renu
Functional significance of minor structural and expression changes in stress chaperone mortalin.
Annals of the New York Academy of Sciences 2007;1119():165-75.
2007: Shiota Maki; Ikeda Yutaka; Kaul Zeenia; Itadani Jun; Kaul Sunil C; Wadhwa Renu
Internalizing antibody-based targeted gene delivery for human cancer cells.
Human gene therapy 2007;18(11):1153-60.
2007: Deocaris Custer C; Widodo Nashi; Shrestha Bhupal G; Kaur Kamaljit; Ohtaka Manami; Yamasaki Kazuhiko; Kaul Sunil C; Wadhwa Renu
Mortalin sensitizes human cancer cells to MKT-077-induced senescence.
Cancer letters 2007;252(2):259-69.
2007: Inoue Atsushi; Sawata Shinya Y; Taira Kazunari; Wadhwa Renu
Loss-of-function screening by randomized intracellular antibodies: identification of hnRNP-K as a potential target for metastasis.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(21):8983-8.
2007: Kaul Zeenia; Yaguchi Tomoko; Chiura Hiroshi X; Kaul Sunil C; Wadhwa Renu
Quantum dot-based mortalin staining as a visual assay for detection of induced senescence in cancer cells.
Annals of the New York Academy of Sciences 2007;1100():368-72.
2007: Kamrul Hasan M; Wadhwa Renu; Kaul Sunil C
CARF binds to three members (ARF, p53, and HDM2) of the p53 tumor-suppressor pathway.
Annals of the New York Academy of Sciences 2007;1100():312-5.
2007: Yaguchi Tomoko; Aida Satoshi; Kaul Sunil C; Wadhwa Renu
Involvement of mortalin in cellular senescence from the perspective of its mitochondrial import, chaperone, and oxidative stress management functions.
Annals of the New York Academy of Sciences 2007;1100():306-11.
2007: Widodo Nashi; Kaur Kamaljit; Shrestha Bhupal G; Takagi Yasuomi; Ishii Tetsuro; Wadhwa Renu; Kaul Sunil C
Selective killing of cancer cells by leaf extract of Ashwagandha: identification of a tumor-inhibitory factor and the first molecular insights to its effect.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(7):2298-306.
2007: Kaul Sunil C; Deocaris Custer C; Wadhwa Renu
Three faces of mortalin: a housekeeper, guardian and killer.
Experimental gerontology 2007;42(4):263-74.
2007: Widodo Nashi; Deocaris Custer C; Kaur Kamaljit; Hasan Kamrul; Yaguchi Tomoko; Yamasaki Kazuhiko; Sugihara Takashi; Ishii Tetsuro; Wadhwa Renu; Kaul Sunil C
Stress chaperones, mortalin, and pex19p mediate 5-aza-2' deoxycytidine-induced senescence of cancer cells by DNA methylation-independent pathway.
The journals of gerontology. Series A, Biological sciences and medical sciences 2007;62(3):246-55.
2007: Kaul Zeenia; Yaguchi Tomoko; Harada Jun I; Ikeda Yutaka; Hirano Takashi; Chiura Hiroshi X; Kaul Sunil C; Wadhwa Renu
An antibody-conjugated internalizing quantum dot suitable for long-term live imaging of cells.
Biochemistry and cell biology = Biochimie et biologie cellulaire 2007;85(1):133-40.
2007: Deocaris Custer C; Kaul Sunil C; Wadhwa Renu
Use of ribozymes in cellular aging research.
Methods in molecular biology (Clifton, N.J.) 2007;371():209-26.
2006: Wadhwa Renu; Takano Syuichi; Kaur Kamaljit; Deocaris Custer C; Pereira-Smith Olivia M; Reddel Roger R; Kaul Sunil C
Upregulation of mortalin/mthsp70/Grp75 contributes to human carcinogenesis.
International journal of cancer. Journal international du cancer 2006;118(12):2973-80.
2006: Deocaris Custer C; Shrestha Bhupal G; Kraft David C; Yamasaki Kazuhiko; Kaul Sunil C; Rattan Suresh I S; Wadhwa Renu
Geroprotection by glycerol: insights to its mechanisms and clinical potentials.
Annals of the New York Academy of Sciences 2006;1067():488-92.
2006: Kaul Zeenia; Yaguchi Tomoko; Kaul Sunil C; Wadhwa Renu
Quantum dot-based protein imaging and functional significance of two mitochondrial chaperones in cellular senescence and carcinogenesis.
Annals of the New York Academy of Sciences 2006;1067():469-73.
2006: Kraft David Christian; Deocaris Custer C; Wadhwa Renu; Rattan Suresh I S
Preincubation with the proteasome inhibitor MG-132 enhances proteasome activity via the Nrf2 transcription factor in aging human skin fibroblasts.
Annals of the New York Academy of Sciences 2006;1067():420-4.
2006: Deocaris Custer C; Yamasaki Kazuhiko; Kaul Sunil C; Wadhwa Renu
Structural and functional differences between mouse mot-1 and mot-2 proteins that differ in two amino acids.
Annals of the New York Academy of Sciences 2006;1067():220-3.
2006: Kaul Sunil C; Hasan Kamrul; Wadhwa Renu
CARF regulates p19ARF-p53-p21WAF1 senescence pathway by multiple checkpoints.
Annals of the New York Academy of Sciences 2006;1067():217-9.
2006: Shiota Maki; Ikeda Yutaka; Wadhwa Renu
The factors that contribute to the long-term expression of siRNA.
Nucleic acids symposium series (2004) 2006;(50):243-4.
2006: Deocaris Custer C; Kaul Sunil C; Wadhwa Renu
On the brotherhood of the mitochondrial chaperones mortalin and heat shock protein 60.
Cell stress & chaperones 2006;11(2):116-28.
2005: Kaul Sunil C; Aida Satoshi; Yaguchi Tomoko; Kaur Kamaljit; Wadhwa Renu
Activation of wild type p53 function by its mortalin-binding, cytoplasmically localizing carboxyl terminus peptides.
The Journal of biological chemistry 2005;280(47):39373-9.
2005: Wadhwa Renu; Takano Syuichi; Kaur Kamaljit; Aida Satoshi; Yaguchi Tomoko; Kaul Zeenia; Hirano Takashi; Taira Kazunari; Kaul Sunil C
Identification and characterization of molecular interactions between mortalin/mtHsp70 and HSP60.
The Biochemical journal 2005;391(Pt 2):185-90.
2005: Arya Harinder; Kaul Zeenia; Wadhwa Renu; Taira Kazunari; Hirano Takashi; Kaul Sunil C
Quantum dots in bio-imaging: Revolution by the small.
Biochemical and biophysical research communications 2005;329(4):1173-7.
2005: Wadhwa Renu; Deocaris Custer C; Widodo Nashi; Taira Kazunari; Kaul Sunil C
Imminent approaches towards molecular interventions in ageing.
Mechanisms of ageing and development 2005;126(4):481-90.
2005: Deocaris Custer C; Taira Kazunari; Kaul Sunil C; Wadhwa Renu
Mimotope-hormesis and mortalin/grp75/mthsp70: a new hypothesis on how infectious disease-associated epitope mimicry may explain low cancer burden in developing nations.
FEBS letters 2005;579(3):586-90.
2005: Rani G; Kaur K; Wadhwa R; Kaul S C; Nagpal A
Evaluation of the anti-genotoxicity of leaf extract of Ashwagandha.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2005;43(1):95-8.
2005: Miyagishi Makoto; Matsumoto Sahohime; Akashi Hideo; Kawasaki Hiroaki; Fukao Taro; Fukuda Yoko; Sano Masayuki; Kato Yoshio; Takagi Yasuomi; Tanaka Yoshiyuki; Warashina Masaki; Kuwabara Tomoko; Sawata Shinya Y; Ikeda Yutaka; Kawahara Shun-ichi; Sunil Kaul C; Wadhwa Renu; Taira Kazunari
Chemistry-based RNA technologies: demonstration of usefulness of libraries of ribozymes and short hairpin RNAs (shRNAs).
Nucleic acids symposium series (2004) 2005;(49):91-2.
2004: Kaur K; Rani G; Widodo Nashi; Nagpal A; Taira K; Kaul S C; Wadhwa R
Evaluation of the anti-proliferative and anti-oxidative activities of leaf extract from in vivo and in vitro raised Ashwagandha.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2004;42(12):2015-20.
2004: Wadhwa Renu; Yaguchi Tomoko; Kaur Kamaljit; Suyama Eigo; Kawasaki Hiroyuki; Taira Kazunari; Kaul Sunil C
Use of a randomized hybrid ribozyme library for identification of genes involved in muscle differentiation.
The Journal of biological chemistry 2004;279(49):51622-9.
2004: Wadhwa Renu; Kaul Sunil C; Miyagishi Makoto; Taira Kazunari
Know-how of RNA interference and its applications in research and therapy.
Mutation research 2004;567(1):71-84.
2004: Suyama Eigo; Wadhwa Renu; Kaur Kamaljit; Miyagishi Makoto; Kaul Sunil C; Kawasaki Hiroaki; Taira Kazunari
Identification of metastasis-related genes in a mouse model using a library of randomized ribozymes.
The Journal of biological chemistry 2004;279(37):38083-6.
2004: Wadhwa Renu; Kaul Sunil C; Miyagishi Makoto; Taira Kazunari
Vectors for RNA interference.
Current opinion in molecular therapeutics 2004;6(4):367-72.
2004: Deocaris Custer C; Kaul Sunil C; Taira Kazunari; Wadhwa Renu
Emerging technologies: trendy RNA tools for aging research.
The journals of gerontology. Series A, Biological sciences and medical sciences 2004;59(8):771-83.
2004: Hasan Md Kamrul; Yaguchi Tomoko; Minoda Yasumasu; Hirano Takashi; Taira Kazunari; Wadhwa Renu; Kaul Sunil C
Alternative reading frame protein (ARF)-independent function of CARF (collaborator of ARF) involves its interactions with p53: evidence for a novel p53-activation pathway and its negative feedback control.
The Biochemical journal 2004;380(Pt 3):605-10.
2004: Wadhwa Renu; Takano Syuichi; Taira Kazunari; Kaul Sunil C
Reduction in mortalin level by its antisense expression causes senescence-like growth arrest in human immortalized cells.
The journal of gene medicine 2004;6(4):439-44.
2004: Kawasaki Hiroaki; Wadhwa Renu; Taira Kazunari
World of small RNAs: from ribozymes to siRNA and miRNA.
Differentiation; research in biological diversity 2004;72(2-3):58-64.
2004: Suyama Eigo; Wadhwa Renu; Kawasaki Hiroaki; Yaguchi Tomoko; Kaul Sunil C; Nakajima Motowo; Taira Kazunari
LIM kinase-2 targeting as a possible anti-metastasis therapy.
The journal of gene medicine 2004;6(3):357-63.
2004: Okabe Jun; Eguchi Akiko; Wadhwa Renu; Rakwal Randeep; Tsukinoki Rumi; Hayakawa Takao; Nakanishi Mahito
Limited capacity of the nuclear matrix to bind telomere repeat binding factor TRF1 may restrict the proliferation of mortal human fibroblasts.
Human molecular genetics 2004;13(3):285-93.
2004: Wadhwa R; Sugihara T; Taira K; Kaul S C
The ARF-p53 senescence pathway in mouse and human cells.
Histology and histopathology 2004;19(1):311-6.
2004: Suyama Eigo; Kawasaki Hiroaki; Wadhwa Renu; Taira Kazunari
Cell migration and metastasis as targets of small RNA-based molecular genetic analyses.
Journal of muscle research and cell motility 2004;25(4-5):303-8.
2003: Kaul Zeenia; Yaguchi Tomoko; Kaul Sunil C; Hirano Takashi; Wadhwa Renu; Taira Kazunari
Mortalin imaging in normal and cancer cells with quantum dot immuno-conjugates.
Cell research 2003;13(6):503-7.
2003: Wadhwa Renu; Ando Hiroshi; Kawasaki Hiroaki; Taira Kazunari; Kaul Sunil C
Targeting mortalin using conventional and RNA-helicase-coupled hammerhead ribozymes.
EMBO reports 2003;4(6):595-601.
2003: Kaul Sunil C; Yaguchi Tomoko; Taira Kazunari; Reddel Roger R; Wadhwa Renu
Overexpressed mortalin (mot-2)/mthsp70/GRP75 and hTERT cooperate to extend the in vitro lifespan of human fibroblasts.
Experimental cell research 2003;286(1):96-101.
2003: Wadhwa Renu; Yaguchi Tomoko; Hasan Md Kamrul; Taira Kazunari; Kaul Sunil C
Mortalin-MPD (mevalonate pyrophosphate decarboxylase) interactions and their role in control of cellular proliferation.
Biochemical and biophysical research communications 2003;302(4):735-42.
2003: Wadhwa Renu; Sugihara Takashi; Hasan Md Kamrul; Duncan Emma L; Taira Kazunari; Kaul Sunil C
A novel putative collaborator of p19ARF.
Experimental gerontology 2003;38(3):245-52.
2002: Kaul Sunil C; Taira Kazunari; Pereira-Smith Olivia M; Wadhwa Renu
Mortalin: present and prospective.
Experimental gerontology 2002;37(10-11):1157-64.
2002: Wadhwa R; Taira K; Kaul S C
Mortalin: a potential candidate for biotechnology and biomedicine.
Histology and histopathology 2002;17(4):1173-7.
2002: Hasan Md Kamrul; Yaguchi Tomoko; Sugihara Takashi; Kumar Penmetcha K R; Taira Kazunari; Reddel Roger R; Kaul Sunil C; Wadhwa Renu
CARF is a novel protein that cooperates with mouse p19ARF (human p14ARF) in activating p53.
The Journal of biological chemistry 2002;277(40):37765-70.
2002: Wadhwa Renu; Sugihara Takashi; Hasan Md Kamrul; Taira Kazunari; Reddel Roger R; Kaul Sunil C
A major functional difference between the mouse and human ARF tumor suppressor proteins.
The Journal of biological chemistry 2002;277(39):36665-70.
2002: Wadhwa Renu; Taira Kazunari; Kaul Sunil C
An Hsp70 family chaperone, mortalin/mthsp70/PBP74/Grp75: what, when, and where?
Cell stress & chaperones 2002;7(3):309-16.
2002: Wadhwa Renu; Yaguchi Tomoko; Hasan Md K; Mitsui Youji; Reddel Roger R; Kaul Sunil C
Hsp70 family member, mot-2/mthsp70/GRP75, binds to the cytoplasmic sequestration domain of the p53 protein.
Experimental cell research 2002;274(2):246-53.
2001: Sugihara T; Kaul S C; Kato J; Reddel R R; Nomura H; Wadhwa R
Pex19p dampens the p19ARF-p53-p21WAF1 tumor suppressor pathway.
The Journal of biological chemistry 2001;276(22):18649-52.
2001: Takano S; Wadhwa R; Mitsui Y; Kaul S C
p53-independent upregulation of p21WAF1 in NIH 3T3 cells malignantly transformed by mot-2.
Cell research 2001;11(1):55-60.
2000: Duncan E L; Wadhwa R; Kaul S C
Senescence and immortalization of human cells.
Biogerontology 2000;1(2):103-21.
2000: Wadhwa R; Kaul S C; Mitsui Y
Cellular mortality and immortalization: a complex interplay of multiple gene functions.
Progress in molecular and subcellular biology 2000;24():191-204.
1999: Wadhwa R; Takano S; Mitsui Y; Kaul S C
NIH 3T3 cells malignantly transformed by mot-2 show inactivation and cytoplasmic sequestration of the p53 protein.
Cell research 1999;9(4):261-9.
1999: Wadhwa R; Sugihara T; Yoshida A; Duncan E L; Hardeman E C; Nomura H; Reddel R R; Kaul S C
Cloning and characterization of a novel gene, striamin, that interacts with the tumor suppressor protein p53.
The Journal of biological chemistry 1999;274(21):14948-55.
1998: Wadhwa R; Takano S; Robert M; Yoshida A; Nomura H; Reddel R R; Mitsui Y; Kaul S C
Inactivation of tumor suppressor p53 by mot-2, a hsp70 family member.
The Journal of biological chemistry 1998;273(45):29586-91.
1998: Sugihara T; Wadhwa R; Kaul S C; Mitsui Y
A novel alternatively spliced form of murine vascular endothelial growth factor, VEGF 115.
The Journal of biological chemistry 1998;273(5):3033-8.

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Renu Wadhwa

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