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Conrad Wagner

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S. Harvey Mudd; Richard Schroer; Sally P Stabler; Conrad Wagner; Jing Wang; Robert H Allen; Zigmund Luka; Timothy Wood; Lee-Jun Wong
Two patients with hepatic mtDNA depletion syndromes and marked elevations of S-adenosylmethionine and methionine.
Zigmund Luka; Frank Moss; Lioudmila V Loukachevitch; Darryl J Bornhop; Conrad Wagner
Histone demethylase LSD1 is a folate-binding protein.
Sally Stabler; Conrad Wagner; Zhiguo Zhao; Robert H Allen; Peter E Clark; Tatsuki Koyama; Lioudmila V Loukachevitch; Zigmund Luka; Magaly Martinez-Ferrer; Neil A Bhowmick
Serum methionine metabolites are risk factors for metastatic prostate cancer progression.

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2012: S. Harvey Mudd; Richard Schroer; Sally P Stabler; Conrad Wagner; Jing Wang; Robert H Allen; Zigmund Luka; Timothy Wood; Lee-Jun Wong
Two patients with hepatic mtDNA depletion syndromes and marked elevations of S-adenosylmethionine and methionine.
Molecular genetics and metabolism 2012;105(2):228-36.
2011: Zigmund Luka; Frank Moss; Lioudmila V Loukachevitch; Darryl J Bornhop; Conrad Wagner
Histone demethylase LSD1 is a folate-binding protein.
Biochemistry 2011;50(21):4750-6.
2011: Sally Stabler; Conrad Wagner; Zhiguo Zhao; Robert H Allen; Peter E Clark; Tatsuki Koyama; Lioudmila V Loukachevitch; Zigmund Luka; Magaly Martinez-Ferrer; Neil A Bhowmick
Serum methionine metabolites are risk factors for metastatic prostate cancer progression.
PloS one 2011;6(8):e22486.
2010: Randall Grubbs; Oliver Vugrek; Jeremy Deisch; Conrad Wagner; Sally P Stabler; Robert Allen; Ivo Barić; Marko Rados; S Harvey Mudd
S-adenosylhomocysteine hydrolase deficiency: two siblings with fetal hydrops and fatal outcomes.
Journal of inherited metabolic disease 2010;33(6):705-13.
2010: Jonathan Barr; Mercedes vázquez-chantada; Cristina Alonso; Miriam Pérez-Cormenzana; Rebeca Mayo; Asier Galán; Juan Caballería; Antonio Martín-Duce; Albert Tran; Conrad Wagner; Zigmund Luka; Shelly C Lu; Azucena Castro; Yannick Le Marchand-Brustel; M Luz Martínez-Chantar; nicolas veyrie; Karine Clément; Joan Tordjman; Philippe Gual; José M Mato
Liquid chromatography-mass spectrometry-based parallel metabolic profiling of human and mouse model serum reveals putative biomarkers associated with the progression of nonalcoholic fatty liver disease.
Journal of proteome research 2010;9(9):4501-12.
2010: Conrad Wagner
Some more comments on 'folate deficiency in chronic pancreatitis'.
JOP : Journal of the pancreas 2010;11(6):646-7; author reply 651-3.
2009: Zigmund Luka; S Harvey Mudd; Conrad Wagner
Glycine N-methyltransferase and regulation of S-adenosylmethionine levels.
The Journal of biological chemistry 2009;284(34):22507-11.
2009: Conrad Wagner; Zigmund Luka; José M Mato
Hepatocellular carcinoma in GNMT-/- mice.
Toxicology and applied pharmacology 2009;237(2):246; author reply 247.
2008: Kwangsuk Ko; Heping Yang; Mazen Noureddin; Ainhoa Iglesia-Ara; Meng Xia; Conrad Wagner; Zigmund Luka; José M Mato; Shelly C Lu
Changes in S-adenosylmethionine and GSH homeostasis during endotoxemia in mice.
Laboratory investigation; a journal of technical methods and pathology 2008;88(10):1121-9.
2008: Zigmund Luka; Lioudmila V Loukachevitch; Conrad Wagner
Acetylation of N-terminal valine of glycine N-methyltransferase affects enzyme inhibition by folate.
Biochimica et biophysica acta 2008;1784(9):1342-6.
2008: M Luz Martínez-Chantar; Mercedes vázquez-chantada; Usue Ariz; Nuria Martínez; Marta Varela; Zigmund Luka; Antonieta Capdevila; Juan Rodríguez; Ana M Aransay; Rune Matthiesen; Heping Yang; Diego F Calvisi; Manel Esteller; Mario Fraga; Shelly C Lu; Conrad Wagner; José M Mato
Loss of the glycine N-methyltransferase gene leads to steatosis and hepatocellular carcinoma in mice.
Hepatology (Baltimore, Md.) 2008;47(4):1191-9.
2007: Conrad Wagner; Mark J Koury
S-Adenosylhomocysteine: a better indicator of vascular disease than homocysteine?
The American journal of clinical nutrition 2007;86(6):1581-5.
2007: Antonieta Capdevila; Raymond F Burk; Joshua Freedman; Frank Frantzen; Ingrid Alfheim; Conrad Wagner
A simple rapid immunoassay for S-adenosylhomocysteine in plasma.
The Journal of nutritional biochemistry 2007;18(12):827-31.
2007: Zigmund Luka; Svetlana Pakhomova; Yury Luka; Marcia E Newcomer; Conrad Wagner
Destabilization of human glycine N-methyltransferase by H176N mutation.
Protein science : a publication of the Protein Society 2007;16(9):1957-64.
2007: Zigmund Luka; Svetlana Pakhomova; Lioudmila V Loukachevitch; Martin Egli; Marcia E Newcomer; Conrad Wagner
5-methyltetrahydrofolate is bound in intersubunit areas of rat liver folate-binding protein glycine N-methyltransferase.
The Journal of biological chemistry 2007;282(6):4069-75.
2007: S Harvey Mudd; John T Brosnan; Margaret E Brosnan; René L Jacobs; Sally P Stabler; Robert H Allen; Dennis E Vance; Conrad Wagner
Methyl balance and transmethylation fluxes in humans.
The American journal of clinical nutrition 2007;85(1):19-25.
2006: N R M Buist; Byron Glenn; Oliver Vugrek; Conrad Wagner; Sally P Stabler; Robert H Allen; Igor P Pogribny; Andreas Schulze; Steven H Zeisel; I Barić; S Harvey Mudd
S-adenosylhomocysteine hydrolase deficiency in a 26-year-old man.
Journal of inherited metabolic disease 2006;29(4):538-45.
2006: Zigmund Luka; Antonieta Capdevila; José M Mato; Conrad Wagner
A glycine N-methyltransferase knockout mouse model for humans with deficiency of this enzyme.
Transgenic research 2006;15(3):393-7.
2006: Zigmund Luka; Amy-Joan L Ham; Jeremy L Norris; Eui-Ju Yeo; Valery Yermalitsky; Byron Glenn; Richard M Caprioli; Daniel C Liebler; Conrad Wagner
Identification of phosphorylation sites in glycine N-methyltransferase from rat liver.
Protein science : a publication of the Protein Society 2006;15(4):785-94.
2006: Kathy Jabs; Mark J Koury; William D Dupont; Conrad Wagner
Relationship between plasma S-adenosylhomocysteine concentration and glomerular filtration rate in children.
Metabolism: clinical and experimental 2006;55(2):252-7.
2005: I Barić; Mario Cuk; K Fumić; Oliver Vugrek; Robert H Allen; Byron Glenn; Miljenka Maradin; Leo Pazanin; Igor P Pogribny; Marko Rados; Vladimir Sarnavka; Andreas Schulze; Sally P Stabler; Conrad Wagner; Steven H Zeisel; S Harvey Mudd
S-Adenosylhomocysteine hydrolase deficiency: a second patient, the younger brother of the index patient, and outcomes during therapy.
Journal of inherited metabolic disease 2005;28(6):885-902.
2004: Svetlana Pakhomova; Zigmund Luka; Steffi Grohmann; Conrad Wagner; Marcia E Newcomer
Glycine N-methyltransferases: a comparison of the crystal structures and kinetic properties of recombinant human, mouse and rat enzymes.
Proteins 2004;57(2):331-7.
2004: Ivo Baric; Ksenija Fumic; Byron Glenn; Mario Cuk; Andreas Schulze; James D Finkelstein; S Jill James; Vlatka Mejaski-Bosnjak; Leo Pazanin; Igor P Pogribny; Marko Rados; Vladimir Sarnavka; Mira Scukanec-Spoljar; Robert H Allen; Sally P Stabler; Lidija Uzelac; Oliver Vugrek; Conrad Wagner; Steven H Zeisel; S Harvey Mudd
S-adenosylhomocysteine hydrolase deficiency in a human: a genetic disorder of methionine metabolism.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(12):4234-9.
2003: Zigmund Luka; Conrad Wagner
Effect of naturally occurring mutations in human glycine N-methyltransferase on activity and conformation.
Biochemical and biophysical research communications 2003;312(4):1067-72.
2003: Zigmund Luka; Conrad Wagner
Human glycine N-methyltransferase is unfolded by urea through a compact monomer state.
Archives of biochemistry and biophysics 2003;420(1):153-60.
2003: S Harvey Mudd; Nancy Braverman; Martin G Pomper; Kamer Tezcan; Jonathan Kronick; Parul Jayakar; Cheryl Garganta; Mary G Ampola; Harvey L Levy; Shawn E McCandless; Hobart Wiltse; Sally P Stabler; Robert H Allen; Conrad Wagner; Marlene W Borschel
Infantile hypermethioninemia and hyperhomocysteinemia due to high methionine intake: a diagnostic trap.
Molecular genetics and metabolism 2003;79(1):6-16.
2003: Zigmund Luka; Conrad Wagner
Expression and purification of glycine N-methyltransferases in Escherichia coli.
Protein expression and purification 2003;28(2):280-6.
2003: P Augoustides-Savvopoulou; Zigmund Luka; Stavroula Karyda; Sally P Stabler; Robert H Allen; Kalliopi Patsiaoura; Conrad Wagner; S Harvey Mudd
Glycine N -methyltransferase deficiency: a new patient with a novel mutation.
Journal of inherited metabolic disease 2003;26(8):745-59.
2003: S Harvey Mudd; Albert Tangerman; Sally P Stabler; Robert H Allen; Conrad Wagner; Steven H Zeisel; Harvey L Levy
Maternal methionine adenosyltransferase I/III deficiency: reproductive outcomes in a woman with four pregnancies.
Journal of inherited metabolic disease 2003;26(5):443-58.
2002: E M Cottington; Christian LaMantia; Sally P Stabler; Robert H Allen; Albert Tangerman; Conrad Wagner; Steven H Zeisel; S Harvey Mudd
Adverse event associated with methionine loading test: a case report.
Arteriosclerosis, thrombosis, and vascular biology 2002;22(6):1046-50.
2002: Reza Yaghmai; Amir H Kashani; Michael T Geraghty; Jay Okoh; Martin G Pomper; Albert Tangerman; Conrad Wagner; Sally P Stabler; Robert H Allen; S Harvey Mudd; Nancy Braverman
Progressive cerebral edema associated with high methionine levels and betaine therapy in a patient with cystathionine beta-synthase (CBS) deficiency.
American journal of medical genetics 2002;108(1):57-63.
2002: Zigmund Luka; Roberto Cerone; John A Phillips; Harvey S Mudd; Conrad Wagner
Mutations in human glycine N-methyltransferase give insights into its role in methionine metabolism.
Human genetics 2002;110(1):68-74.
2001: DM Kerins; Mark J Koury; Antonieta Capdevila; S Rana; Conrad Wagner
Plasma S-adenosylhomocysteine is a more sensitive indicator of cardiovascular disease than plasma homocysteine.
The American journal of clinical nutrition 2001;74(6):723-9.
2001: S Harvey Mudd; Roberto Cerone; Maria Cristina Schiaffino; AR Fantasia; Giuseppe Minniti; Ubaldo Caruso; R Lorini; D Watkins; NV Matiaszuk; David S Rosenblatt; B Schwahn; R Rozen; Leighton H Legros; Malak Kotb; Antonieta Capdevila; Zigmund Luka; James D Finkelstein; Albert Tangerman; Sally P Stabler; Robert H Allen; Conrad Wagner
Glycine N-methyltransferase deficiency: a novel inborn error causing persistent isolated hypermethioninaemia.
Journal of inherited metabolic disease 2001;24(4):448-64.
2000: S Harvey Mudd; Donald J Jenden; Antonieta Capdevila; Margareth Roch; Harvey L Levy; Conrad Wagner
Isolated hypermethioninemia: measurements of S-adenosylmethionine and choline.
Metabolism: clinical and experimental 2000;49(12):1542-7.
1999: E J Yeo; W T Briggs; Conrad Wagner
Inhibition of glycine N-methyltransferase by 5-methyltetrahydrofolate pentaglutamate.
The Journal of biological chemistry 1999;274(53):37559-64.
1999: Sergey A Krupenko; Conrad Wagner
Aspartate 142 is involved in both hydrolase and dehydrogenase catalytic centers of 10-formyltetrahydrofolate dehydrogenase.
The Journal of biological chemistry 1999;274(50):35777-84.
1998: Antonieta Capdevila; Conrad Wagner
Measurement of plasma S-adenosylmethionine and S-adenosylhomocysteine as their fluorescent isoindoles.
Analytical biochemistry 1998;264(2):180-4.
1998: Sergey A Krupenko; Conrad Wagner
Overexpression of functional hydrolase domain of rat liver 10-formyltetrahydrofolate dehydrogenase in Escherichia coli.
Protein expression and purification 1998;14(1):146-52.
1998: Rekha Pattanayek; Marcia E Newcomer; Conrad Wagner
Crystal structure of apo-glycine N-methyltransferase (GNMT).
Protein science : a publication of the Protein Society 1998;7(6):1326-31.
1997: Natalia I Krupenko; Conrad Wagner
Transport of rat liver glycine N-methyltransferase into rat liver nuclei.
The Journal of biological chemistry 1997;272(43):27140-6.
1997: Antonieta Capdevila; W Decha-Umphai; K H Song; R T Borchardt; Conrad Wagner
Pancreatic exocrine secretion is blocked by inhibitors of methylation.
Archives of biochemistry and biophysics 1997;345(1):47-55.
1997: Sergey A Krupenko; Conrad Wagner; robert cook
Domain structure of rat 10-formyltetrahydrofolate dehydrogenase. Resolution of the amino-terminal domain as 10-formyltetrahydrofolate hydrolase.
The Journal of biological chemistry 1997;272(15):10273-8.
1997: Sergey A Krupenko; Conrad Wagner; robert cook
Expression, purification, and properties of the aldehyde dehydrogenase homologous carboxyl-terminal domain of rat 10-formyltetrahydrofolate dehydrogenase.
The Journal of biological chemistry 1997;272(15):10266-72.
1996: Conrad Wagner
Symposium on the subcellular compartmentation of folate metabolism.
The Journal of nutrition 1996;126(4 Suppl):1228S-34S.
1995: robert cook; Conrad Wagner
Enzymatic activities of rat liver cytosol 10-formyltetrahydrofolate dehydrogenase.
Archives of biochemistry and biophysics 1995;321(2):336-44.
1995: Sergey A Krupenko; D A Horstman; Conrad Wagner; robert cook
Baculovirus expression and purification of rat 10-formyltetrahydrofolate dehydrogenase.
Protein expression and purification 1995;6(4):457-64.
1995: Sergey A Krupenko; Conrad Wagner; robert cook
Recombinant 10-formyltetrahydrofolate dehydrogenase catalyses both dehydrogenase and hydrolase reactions utilizing the synthetic substrate 10-formyl-5,8-dideazafolate.
The Biochemical journal 1995;306 ( Pt 3)():651-5.
1995: Sergey A Krupenko; Conrad Wagner; robert cook
Cysteine 707 is involved in the dehydrogenase activity site of rat 10-formyltetrahydrofolate dehydrogenase.
The Journal of biological chemistry 1995;270(2):519-22.
1995: Conrad Wagner; W T Briggs; D W Horne; robert cook
10-Formyltetrahydrofolate dehydrogenase: identification of the natural folate ligand, covalent labeling, and partial tryptic digestion.
Archives of biochemistry and biophysics 1995;316(1):141-7.
1994: E J Yeo; Conrad Wagner
Tissue distribution of glycine N-methyltransferase, a major folate-binding protein of liver.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(1):210-4.
1993: M Balaghi; D W Horne; S C Woodward; Conrad Wagner
Pancreatic one-carbon metabolism in early folate deficiency in rats.
The American journal of clinical nutrition 1993;58(2):198-203.
1993: M Balaghi; Conrad Wagner
DNA methylation in folate deficiency: use of CpG methylase.
Biochemical and biophysical research communications 1993;193(3):1184-90.
1993: M Balaghi; D W Horne; Conrad Wagner
Hepatic one-carbon metabolism in early folate deficiency in rats.
The Biochemical journal 1993;291 ( Pt 1)():145-9.
1992: E J Yeo; Conrad Wagner
Purification and properties of pancreatic glycine N-methyltransferase.
The Journal of biological chemistry 1992;267(34):24669-74.
1992: M Balaghi; Conrad Wagner
Methyl group metabolism in the pancreas of folate-deficient rats.
The Journal of nutrition 1992;122(7):1391-6.
1991: robert cook; R Stephen Lloyd; Conrad Wagner
Isolation and characterization of cDNA clones for rat liver 10-formyltetrahydrofolate dehydrogenase.
The Journal of biological chemistry 1991;266(8):4965-73.
1990: B M Wickwire; Conrad Wagner; H P Broquist
Pipecolic acid biosynthesis in Rhizoctonia leguminicola. II. Saccharopine oxidase: a unique flavin enzyme involved in pipecolic acid biosynthesis.
The Journal of biological chemistry 1990;265(25):14748-53.
1989: Conrad Wagner; W Decha-Umphai; J Corbin
Phosphorylation modulates the activity of glycine N-methyltransferase, a folate binding protein. In vitro phosphorylation is inhibited by the natural folate ligand.
The Journal of biological chemistry 1989;264(16):9638-42.
1989: D W Horne; robert cook; Conrad Wagner
Effect of dietary methyl group deficiency on folate metabolism in rats.
The Journal of nutrition 1989;119(4):618-21.
1989: robert cook; D W Horne; Conrad Wagner
Effect of dietary methyl group deficiency on one-carbon metabolism in rats.
The Journal of nutrition 1989;119(4):612-7.
1981: D W Horne; W T Briggs; Conrad Wagner
High-pressure liquid chromatographic separation of the naturally occurring folic acid monoglutamate derivatives.
Analytical biochemistry 1981;116(2):393-7.
1980: D W Horne; W T Briggs; Conrad Wagner
Enzymic synthesis of (d)-L-5-methyltetrahydropteroylglutamate of high specific radioactivity.
Methods in enzymology 1980;66():545-7.