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Carston Wagner

Research Profile

Chemicals & Drugs

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TOP 3
Eva Bjur; Valentina Gandin; Ola Larsson; Shui Li; Nahum Sonenberg; Ivan Topisirovic; Carston R Wagner; Ekaterina Yurchenko; Lei Zheng; Ciriaco Piccirillo
Distinct Translational Control in CD4(+) T Cell Subsets.
Mohammad Rashidian; Rachit Shah; Carston R Wagner; Jonathan K Dozier; Mohammad M Mahmoodi; Mark D Distefano
A highly efficient catalyst for oxime ligation and hydrazone-oxime exchange suitable for bioconjugation.
Shui Li; Joel McCauley; Peter B Bitterman; Blake Jacobson; Yan Jia; Robert Kratzke; Carston R Wagner
Treatment of breast and lung cancer cells with a N-7 benzyl guanosine monophosphate tryptamine phosphoramidate pronucleotide (4Ei-1) results in chemosensitization to gemcitabine and induced eIF4E proteasomal degradation.

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All Publications

2013: Eva Bjur; Valentina Gandin; Ola Larsson; Shui Li; Nahum Sonenberg; Ivan Topisirovic; Carston R Wagner; Ekaterina Yurchenko; Lei Zheng; Ciriaco Piccirillo
Distinct Translational Control in CD4(+) T Cell Subsets.
PLoS genetics 2013;9(5):e1003494.
2013: Mohammad Rashidian; Rachit Shah; Carston R Wagner; Jonathan K Dozier; Mohammad M Mahmoodi; Mark D Distefano
A highly efficient catalyst for oxime ligation and hydrazone-oxime exchange suitable for bioconjugation.
Bioconjugate chemistry 2013;24(3):333-42.
2013: Shui Li; Joel McCauley; Peter B Bitterman; Blake Jacobson; Yan Jia; Robert Kratzke; Carston R Wagner
Treatment of breast and lung cancer cells with a N-7 benzyl guanosine monophosphate tryptamine phosphoramidate pronucleotide (4Ei-1) results in chemosensitization to gemcitabine and induced eIF4E proteasomal degradation.
Molecular pharmaceutics 2013;10(2):523-31.
2012: Adrian Fegan; Sidath C Kumarapperuma; Carston R Wagner
Chemically self-assembled antibody nanostructures as potential drug carriers.
Molecular pharmaceutics 2012;9(11):3218-27.
2012: Brian R White; Jonathan C T Carlson; Jessie L Kerns; Carston R Wagner
Protein interface remodeling in a chemically induced protein dimer.
Journal of molecular recognition : JMR 2012;25(7):393-403.
2012: Yan Jia; Vitaly A Polunovsky; Peter B Bitterman; Carston R Wagner
Cap-dependent translation initiation factor eIF4E: an emerging anticancer drug target.
Medicinal research reviews 2012;32(4):786-814.
2012: Amit Gangar; Sidath C Kumarapperuma; Adrian Fegan; Carston R Wagner
Programmable self-assembly of antibody-oligonucleotide conjugates as small molecule and protein carriers.
Journal of the American Chemical Society 2012;134(6):2895-7.
2011: Brian R White; Qing Li; Carston R Wagner
Chemically induced self-assembly of enzyme nanorings.
Methods in molecular biology (Clifton, N.J.) 2011;743():17-26.
2010: Sanaa Bardaweel; James Pace; Tsui-Fen Chou; Vivian Cody; Carston R Wagner
Probing the impact of the echinT C-terminal domain on structure and catalysis.
Journal of molecular biology 2010;404(4):627-38.
2010: Qing Li; Mehmet Sarikaya; Christopher R So; Daniel A Vallera; Vivian Cody; Adrian Fegan; Carston R Wagner
Chemically self-assembled antibody nanorings (CSANs): design and characterization of an anti-CD3 IgM biomimetic.
Journal of the American Chemical Society 2010;132(48):17247-57.
2010: Adrian Fegan; Brian White; Jonathan C T Carlson; Carston R Wagner
Chemically controlled protein assembly: techniques and applications.
Chemical reviews 2010;110(6):3315-36.
2010: Yan Jia; Ting-Lan Chiu; Elizabeth A Amin; Vitaly Polunovsky; Peter B Bitterman; Carston R Wagner
Design, synthesis and evaluation of analogs of initiation factor 4E (eIF4E) cap-binding antagonist Bn7-GMP.
European journal of medicinal chemistry 2010;45(4):1304-13.
2009: Xin Zhou; Naixia Zhang; Li Liu; Kylie J Walters; Patrick E Hanna; Carston R Wagner
Probing the catalytic potential of the hamster arylamine N-acetyltransferase 2 catalytic triad by site-directed mutagenesis of the proximal conserved residue, Tyr190.
The FEBS journal 2009;276(23):6928-41.
2009: Li Liu; Carston R Wagner; Patrick E Hanna
Isoform-selective inactivation of human arylamine N-acetyltransferases by reactive metabolites of carcinogenic arylamines.
Chemical research in toxicology 2009;22(12):1962-74.
2009: Jilin Cheng; Xin Zhou; Tsui-Fen Chou; Brahma Ghosh; Baoling Liu; Carston R Wagner
Identification of the amino acid-AZT-phosphoramidase by affinity T7 phage display selection.
Bioorganic & medicinal chemistry letters 2009;19(22):6379-81.
2009: H Zhang; X Zeng; Qingsheng Li; Martine Gaillard-Kelly; Carston R Wagner; Douglas Yee
Fluorescent tumour imaging of type I IGF receptor in vivo: comparison of antibody-conjugated quantum dots and small-molecule fluorophore.
British journal of cancer 2009;101(1):71-9.
2009: Brahma Ghosh; Alexey O Benyumov; Phalguni Ghosh; Yan Jia; Svetlana Avdulov; Peter S Dahlberg; Mark Peterson; Karen Smith; Vitaly A Polunovsky; Peter B Bitterman; Carston R Wagner
Nontoxic chemical interdiction of the epithelial-to-mesenchymal transition by targeting cap-dependent translation.
ACS chemical biology 2009;4(5):367-77.
2008: Tsui-Fen Chou; Christopher So; Brian R White; Jonathan C T Carlson; Mehmet Sarikaya; Carston R Wagner
Enzyme nanorings.
ACS nano 2008;2(12):2519-25.
2008: Li Liu; Carston R Wagner; Patrick E Hanna
Human arylamine N-acetyltransferase 1: in vitro and intracellular inactivation by nitrosoarene metabolites of toxic and carcinogenic arylamines.
Chemical research in toxicology 2008;21(10):2005-16.
2008: Phalguni Ghosh; Jilin Cheng; Tsui-Fen Chou; Yan Jia; Svetlana Avdulov; Peter B Bitterman; Vitaly A Polunovsky; Carston R Wagner
Expression, purification and characterization of recombinant mouse translation initiation factor eIF4E as a dihydrofolate reductase (DHFR) fusion protein.
Protein expression and purification 2008;60(2):132-9.
2007: Tsui-Fen Chou; Yuk Y Sham; Carston R Wagner
Impact of the C-terminal loop of histidine triad nucleotide binding protein1 (Hint1) on substrate specificity.
Biochemistry 2007;46(45):13074-9.
2007: Tsui-Fen Chou; Jilin Cheng; Ilya B Tikh; Carston R Wagner
Evidence that human histidine triad nucleotide binding protein 3 (Hint3) is a distinct branch of the histidine triad (HIT) superfamily.
Journal of molecular biology 2007;373(4):978-89.
2007: Li Liu; Annette Von Vett; Naixia Zhang; Kylie J Walters; Carston R Wagner; Patrick E Hanna
Arylamine N-acetyltransferases: characterization of the substrate specificities and molecular interactions of environmental arylamines with human NAT1 and NAT2.
Chemical research in toxicology 2007;20(9):1300-8.
2007: Tsui-Fen Chou; Ilya B Tikh; Bruno A C Horta; Brahma Ghosh; Ricardo Bicca de Alencastro; Carston R Wagner
Engineered monomeric human histidine triad nucleotide-binding protein 1 hydrolyzes fluorogenic acyl-adenylate and lysyl-tRNA synthetase-generated lysyl-adenylate.
The Journal of biological chemistry 2007;282(20):15137-47.
2007: Tsui-Fen Chou; Janina Baraniak; Renata Kaczmarek; Xin Zhou; Jilin Cheng; Brahma Ghosh; Carston R Wagner
Phosphoramidate pronucleotides: a comparison of the phosphoramidase substrate specificity of human and Escherichia coli histidine triad nucleotide binding proteins.
Molecular pharmaceutics 2007;4(2):208-17.
2007: Tsui-Fen Chou; Carston R Wagner
Lysyl-tRNA synthetase-generated lysyl-adenylate is a substrate for histidine triad nucleotide binding proteins.
The Journal of biological chemistry 2007;282(7):4719-27.
2007: Rodney F Minchin; Patrick E Hanna; Jean-Marie Dupret; Carston R Wagner; Fernando Rodrigues-Lima; Neville J Butcher
Arylamine N-acetyltransferase I.
The international journal of biochemistry & cell biology 2007;39(11):1999-2005.
2006: Naixia Zhang; Li Liu; Fen Liu; Carston R Wagner; Patrick E Hanna; Kylie J Walters
NMR-based model reveals the structural determinants of mammalian arylamine N-acetyltransferase substrate specificity.
Journal of molecular biology 2006;363(1):188-200.
2006: Rahul B Poria; Jeffrey P Norenberg; Tamara L Anderson; Jack Erion; Carston R Wagner; Jeffrey B Arterburn; Richard Larson
Characterization of a radiolabeled small molecule targeting leukocyte function-associated antigen-1 expression in lymphoma and leukemia.
Cancer biotherapy & radiopharmaceuticals 2006;21(5):418-26.
2006: Fen Liu; Naixia Zhang; Xin Zhou; Patrick E Hanna; Carston R Wagner; Deanna M Koepp; Kylie J Walters
Arylamine N-acetyltransferase aggregation and constitutive ubiquitylation.
Journal of molecular biology 2006;361(3):482-92.
2006: Cindy J Choy; Dan P Drontle; Carston R Wagner
Synthesis of amino acid phosphoramidate monoesters via H-phosphonate intermediates.
Current protocols in nucleic acid chemistry / edited by Serge L. Beaucage ... [et al.] 2006;Chapter 15():Unit 15.1.
2006: Jonathan C T Carlson; Sidhartha S Jena; Michelle Flenniken; Tsui-Fen Chou; Ronald A Siegel; Carston R Wagner
Chemically controlled self-assembly of protein nanorings.
Journal of the American Chemical Society 2006;128(23):7630-8.
2005: Haiqing Wang; Li Liu; Patrick E Hanna; Carston R Wagner
Catalytic mechanism of hamster arylamine N-acetyltransferase 2.
Biochemistry 2005;44(33):11295-306.
2005: Jisook Kim; Soobong Park; Natalia Tretyakova; Carston R Wagner
A method for quantitating the intracellular metabolism of AZT amino acid phosphoramidate pronucleotides by capillary high-performance liquid chromatography-electrospray ionization mass spectrometry.
Molecular pharmaceutics 2005;2(3):233-41.
2005: Phalguni Ghosh; Chunkyung Park; Mark S Peterson; Peter B Bitterman; Vitaly A Polunovsky; Carston R Wagner
Synthesis and evaluation of potential inhibitors of eIF4E cap binding to 7-methyl GTP.
Bioorganic & medicinal chemistry letters 2005;15(8):2177-80.
2005: Tsui-Fen Chou; Pawel Bieganowski; Kara Shilinski; Jilin Cheng; Charles Brenner; Carston R Wagner
31P NMR and genetic analysis establish hinT as the only Escherchia coli purine nucleoside phosphoramidase and as essential for growth under high salt conditions.
The Journal of biological chemistry 2005;280(15):15356-61.
2005: Richard Larson; Terry Davis; Cristian Bologa; Gloria Semenuk; Sreejith Vijayan; Yu Li; Tudor I Oprea; Alexandre Chigaev; Tione Buranda; Carston R Wagner; Larry A Sklar
Dissociation of I domain and global conformational changes in LFA-1: refinement of small molecule-I domain structure-activity relationships.
Biochemistry 2005;44(11):4322-31.
2005: Haiqing Wang; Gregory M Vath; Akane Kawamura; Caleb A Bates; Edith Sim; Patrick E Hanna; Carston R Wagner
Over-expression, purification, and characterization of recombinant human arylamine N-acetyltransferase 1.
The protein journal 2005;24(2):65-77.
2005: Haiqing Wang; Carston R Wagner; Patrick E Hanna
Irreversible inactivation of arylamine N-acetyltransferases in the presence of N-hydroxy-4-acetylaminobiphenyl: a comparison of human and hamster enzymes.
Chemical research in toxicology 2005;18(2):183-97.
2005: Akane Kawamura; James Graham; Adeel Mushtaq; Stefanos A Tsiftsoglou; Gregory M Vath; Patrick E Hanna; Carston R Wagner; Edith Sim
Eukaryotic arylamine N-acetyltransferase. Investigation of substrate specificity by high-throughput screening.
Biochemical pharmacology 2005;69(2):347-59.
2004: Carston R Wagner
A dogma in need of a reformation.
Molecular pharmaceutics 2004;1(4):247.
2004: Haiqing Wang; Gregory M Vath; Kara J Gleason; Patrick E Hanna; Carston R Wagner
Probing the mechanism of hamster arylamine N-acetyltransferase 2 acetylation by active site modification, site-directed mutagenesis, and pre-steady state and steady state kinetic studies.
Biochemistry 2004;43(25):8234-46.
2004: Dan P Drontle; Carston R Wagner
Designing a pronucleotide stratagem: lessons from amino acid phosphoramidates of anticancer and antiviral pyrimidines.
Mini reviews in medicinal chemistry 2004;4(4):409-19.
2004: Jisook Kim; Tsui-Fen Chou; George W Griesgraber; Carston R Wagner
Direct measurement of nucleoside monophosphate delivery from a phosphoramidate pronucleotide by stable isotope labeling and LC-ESI(-)-MS/MS.
Molecular pharmaceutics 2004;1(2):102-11.
2004: Zhijun Guo; Carston R Wagner; Patrick E Hanna
Mass spectrometric investigation of the mechanism of inactivation of hamster arylamine N-acetyltransferase 1 by N-hydroxy-2-acetylaminofluorene.
Chemical research in toxicology 2004;17(3):275-86.
2004: Haiqing Wang; Zhijun Guo; Gregory M Vath; Carston R Wagner; Patrick E Hanna
Chemical modification of hamster arylamine N-acetyltransferase 2 with isozyme-selective and nonselective N-arylbromoacetamido reagents.
The protein journal 2004;23(2):153-66.
2004: Jisook Kim; Daniel P Drontle; Carston R Wagner
Monitoring the intracellular metabolism of nucleoside phosphoramidate pronucleotides by 31P NMR.
Nucleosides, nucleotides & nucleic acids 2004;23(1-2):483-93.
2003: Zhijun Guo; Gregory M Vath; Carston R Wagner; Patrick E Hanna
Arylamine N-acetyltransferases: covalent modification and inactivation of hamster NAT1 by bromoacetamido derivatives of aniline and 2-aminofluorene.
Journal of protein chemistry 2003;22(7-8):631-42.
2003: Pamela Pineda; Aaron Kanter; R Scott McIvor; Stephen J Benkovic; Andre Rosowsky; Carston R Wagner
Dihydrofolate reductase mutant with exceptional resistance to methotrexate but not to trimetrexate.
Journal of medicinal chemistry 2003;46(14):2816-8.
2003: Heng Song; Rachel Johns; George W Griesgraber; Carston R Wagner; Cheryl L Zimmerman
Disposition and oral bioavailability in rats of an antiviral and antitumor amino acid phosphoramidate prodrug of AZT-monophosphate.
Pharmaceutical research 2003;20(3):448-51.
2003: Jonathan C T Carlson; Aaron Kanter; Guruvasuthevan R Thuduppathy; Vivian Cody; Pamela E Pineda; R Scott McIvor; Carston R Wagner
Designing protein dimerizers: the importance of ligand conformational equilibria.
Journal of the American Chemical Society 2003;125(6):1501-7.
2002: Helen-Ann Brown Epstein; Peter B Bitterman; Brooke Mossman; Marvin I Schwarz; Dean Sheppard; Laura A Almasy; Harold A Chapman; Scott L Friedman; Talmadge E King; Leslie A Leinwand; Lance Liotta; George R Martin; David A Schwartz; Gregory Schultz; Carston R Wagner; Robert A Musson
Future research directions in idiopathic pulmonary fibrosis: summary of a National Heart, Lung, and Blood Institute working group.
American journal of respiratory and critical care medicine 2002;166(2):236-46.
2002: Heng Song; George W Griesgraber; Carston R Wagner; Cheryl L Zimmerman
Pharmacokinetics of amino acid phosphoramidate monoesters of zidovudine in rats.
Antimicrobial agents and chemotherapy 2002;46(5):1357-63.
2001: Molly Chiaramonte; J L Koviach; C Moore; VV Iyer; Carston R Wagner; Randall L Halcomb; W Miller; Paul Melançon; Robert D Kuchta
Inhibition of CMP-sialic acid transport into Golgi vesicles by nucleoside monophosphates.
Biochemistry 2001;40(47):14260-7.
2001: EJ McIntee; Carston R Wagner
Amino acid phosphoramidate nucleosides: potential ADEPT/GDEPT substrates.
Bioorganic & medicinal chemistry letters 2001;11(21):2803-5.
2001: SL Chang; George W Griesgraber; Carston R Wagner
Comparison of the antiviral activity of hydrophobic amino acid phosphoramidate monoesters of 2'3'-dideoxyadenosine (DDA) and 3'-azido-3'-deoxythymidine (AZT).
Nucleosides, nucleotides & nucleic acids 2001;20(8):1571-82.
2001: S Chang ; George W Griesgraber; P J Southern; Carston R Wagner
Amino acid phosphoramidate monoesters of 3'-azido-3'-deoxythymidine: relationship between antiviral potency and intracellular metabolism.
Journal of medicinal chemistry 2001;44(2):223-31.
2000: Carston R Wagner; VV Iyer; EJ McIntee
Pronucleotides: toward the in vivo delivery of antiviral and anticancer nucleotides.
Medicinal research reviews 2000;20(6):417-51.
2000: VV Iyer; George W Griesgraber; M R Radmer; EJ McIntee; Carston R Wagner
Synthesis, in vitro anti-breast cancer activity, and intracellular decomposition of amino acid methyl ester and alkyl amide phosphoramidate monoesters of 3'-azido-3'-deoxythymidine (AZT).
Journal of medicinal chemistry 2000;43(11):2266-74.
2000: SL Chang; George W Griesgraber; T W Abraham; T Garg; Heng Song; Cheryl L Zimmerman; Carston R Wagner
Synthesis and antiviral activity of amino acid carbamate derivatives of AZT.
Nucleosides, nucleotides & nucleic acids 2000;19(1-2):87-100.
1999: Carston R Wagner; SL Chang; George W Griesgraber; Heng Song; EJ McIntee; Cheryl L Zimmerman
Antiviral nucleoside drug delivery via amino acid phosphoramidates.
Nucleosides & nucleotides 1999;18(4-5):913-9.
1998: K R Sticha; C P Bergstrom; Carston R Wagner; Patrick E Hanna
Characterization of hamster recombinant monomorphic and polymorphic arylamine N-acetyltransferases: bioactivation and mechanism-based inactivation studies with N-hydroxy-2-acetylaminofluorene.
Biochemical pharmacology 1998;56(1):47-59.
1997: EJ McIntee; Rory P Remmel; Ray F Schinazi; T W Abraham; Carston R Wagner
Probing the mechanism of action and decomposition of amino acid phosphomonoester amidates of antiviral nucleoside prodrugs.
Journal of medicinal chemistry 1997;40(21):3323-31.
1997: Carston R Wagner; G Ballato; AO Akanni; EJ McIntee; Richard Larson; S Chang; Y J Abul-Hajj
Potent growth inhibitory activity of zidovudine on cultured human breast cancer cells and rat mammary tumors.
Cancer research 1997;57(12):2341-5.
1997: K R Sticha; C A Sieg; C P Bergstrom; Patrick E Hanna; Carston R Wagner
Overexpression and large-scale purification of recombinant hamster polymorphic arylamine N-acetyltransferase as a dihydrofolate reductase fusion protein.
Protein expression and purification 1997;10(1):141-53.
1996: T W Abraham; T I Kalman; EJ McIntee; Carston R Wagner
Synthesis and biological activity of aromatic amino acid phosphoramidates of 5-fluoro-2'-deoxyuridine and 1-beta-arabinofuranosylcytosine: evidence of phosphoramidase activity.
Journal of medicinal chemistry 1996;39(23):4569-75.
1996: Carston R Wagner; C P Bergstrom; K R Koning; Patrick E Hanna
Arylamine N-acetyltransferases. Expression in Escherichia coli, purification, and substrate specificities of recombinant hamster monomorphic and polymorphic isozymes.
Drug metabolism and disposition: the biological fate of chemicals 1996;24(2):245-53.
1995: C P Bergstrom; Carston R Wagner; D K Ann; Patrick E Hanna
Hamster monomorphic arylamine N-acetyltransferase: expression in Escherichia coli and purification.
Protein expression and purification 1995;6(1):45-55.