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Georges Wagnières

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Filippo Piffaretti; Michel Sickenberg; Edoardo Vezzola; Jean-Pierre Ballini; Roberto Perotti; Matthieu Zellweger; Georges Wagnières
Reflectance imaging of the human retina at 810 nm does not suffice to optimize the parameters of hydrodynamic rebalancing laser treatment.
Filippo Piffaretti; Hubert van den Bergh; Eddy Forte; Rajendran Senthil Kumar; Anna Maria Novello; Patrycja Nowak-Sliwinska; Cédric Paulou; Georges Wagnières
Real-time, in vivo measurement of tissular pO2 through the delayed fluorescence of endogenous protoporphyrin IX during photodynamic therapy.
Patrycja Nowak-Sliwinska; Simon Plyte; Mariangela Storto; Hubert van den Bergh; Jean-Pierre Ballini; Tiziana Cataudella; Randall Gatz; Marco Giorgio; Georges Wagnières
Angiogenesis inhibition by the maleimide-based small molecule GNX-686.

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2012: Filippo Piffaretti; Michel Sickenberg; Edoardo Vezzola; Jean-Pierre Ballini; Roberto Perotti; Matthieu Zellweger; Georges Wagnières
Reflectance imaging of the human retina at 810 nm does not suffice to optimize the parameters of hydrodynamic rebalancing laser treatment.
Journal of biomedical optics 2012;17(11):116027.
2012: Filippo Piffaretti; Hubert van den Bergh; Eddy Forte; Rajendran Senthil Kumar; Anna Maria Novello; Patrycja Nowak-Sliwinska; Cédric Paulou; Georges Wagnières
Real-time, in vivo measurement of tissular pO2 through the delayed fluorescence of endogenous protoporphyrin IX during photodynamic therapy.
Journal of biomedical optics 2012;17(11):115007.
2012: Patrycja Nowak-Sliwinska; Simon Plyte; Mariangela Storto; Hubert van den Bergh; Jean-Pierre Ballini; Tiziana Cataudella; Randall Gatz; Marco Giorgio; Georges Wagnières
Angiogenesis inhibition by the maleimide-based small molecule GNX-686.
Microvascular research 2012;83(2):105-10.
2011: Filippo Piffaretti; Filippo M Piffaretti; Kanappan Santhakumar; Eddy Forte; Hubert van den Bergh; Georges Wagnières
Optical fiber-based setup for in vivo measurement of the delayed fluorescence lifetime of oxygen sensors.
Journal of biomedical optics 2011;16(3):037005.
2011: Patrycja Nowak-Sliwinska; Hubert van den Bergh; Peter Käuper; Georges Wagnières
Study of the pO2-sensitivity of the dendrimeric and free forms of Pd-meso-tetra(4-carboxyphenyl)porphyrin, incorporated or not in chitosan-based nanoparticles.
Chimia 2011;65(9):691-5.
2010: Blaise Lovisa; Patrice Jichlinski; Bernd-Claus Weber; Daniela Aymon; Hubert van den Bergh; Georges Wagnières
High-magnification vascular imaging to reject false-positive sites in situ during Hexvix® fluorescence cystoscopy.
Journal of biomedical optics 2010;15(5):051606.
2010: Frédéric Schmitt; Lucienne Lagopoulos; Peter Käuper; Nathanaël Rossi; Nathalie Busso; Jérôme Barge; Georges Wagnières; Carsten Laue; Christine Wandrey; Lucienne Juillerat-Jeanneret
Chitosan-based nanogels for selective delivery of photosensitizers to macrophages and improved retention in and therapy of articular joints.
Journal of controlled release : official journal of the Controlled Release Society 2010;144(2):242-50.
2010: Patrycja Nowak-Sliwinska; Georges Wagnières; Hubert van den Bergh; Arjan W Griffioen
Angiostasis-induced vascular normalization can improve photodynamic therapy.
Cellular and molecular life sciences : CMLS 2010;67(9):1559-60; author reply 1561.
2010: Siang Hui Lim; Cliferson Thivierge; Patrycja Nowak-Sliwinska; Junyan Han; Hubert van den Bergh; Georges Wagnières; Kevin Burgess; Hong Boon Lee
In vitro and in vivo photocytotoxicity of boron dipyrromethene derivatives for photodynamic therapy.
Journal of medicinal chemistry 2010;53(7):2865-74.
2010: Siang Hui Lim; Patrycja Nowak-Sliwinska; Fadzly Adzhar Kamarulzaman; Hubert van den Bergh; Georges Wagnières; Hong Boon Lee
The neovessel occlusion efficacy of 15-hydroxypurpurin-7-lactone dimethyl ester induced with photodynamic therapy.
Photochemistry and photobiology 2010;86(2):397-402.
2010: Patrycja Nowak-Sliwinska; Jean-Pierre Ballini; Georges Wagnières; Hubert van den Bergh
Processing of fluorescence angiograms for the quantification of vascular effects induced by anti-angiogenic agents in the CAM model.
Microvascular research 2010;79(1):21-8.
2009: Thomas Glanzmann; Matthieu Zellweger; François Borle; Ramiro Conde; Alexandre Radu; Jean-Pierre Ballini; Yves Jaquet; Raphaëlle Pilloud; Hubert van den Bergh; Philippe Monnier; Snezana Andrejevic-Blant; Georges Wagnières
Assessment of a sheep animal model to optimise photodynamic therapy in the oesophagus.
Lasers in surgery and medicine 2009;41(9):643-52.
2009: Pascal Uehlinger; Tanja Gabrecht; Thomas Glanzmann; Jean-Pierre Ballini; Alexandre Radu; Snezana Andrejevic; Philippe Monnier; Georges Wagnières
In vivo time-resolved spectroscopy of the human bronchial early cancer autofluorescence.
Journal of biomedical optics 2009;14(2):024011.
2009: Tanja Gabrecht; Blaise Lovisa; Hubert van den Bergh; Georges Wagnières
Autofluorescence bronchoscopy: quantification of inter-patient variations of fluorescence intensity.
Lasers in medical science 2009;24(1):45-51.
2008: Nora Dögnitz; Denis Salomon; Matthieu Zellweger; Jean-Pierre Ballini; Tanja Gabrecht; Norbert Lange; Hubert van den Bergh; Georges Wagnières
Comparison of ALA- and ALA hexyl-ester-induced PpIX depth distribution in human skin carcinoma.
Journal of photochemistry and photobiology. B, Biology 2008;93(3):140-8.
2008: Tanja Gabrecht; Alexandre Radu; Pierre Grosjean; Bernd Weber; Günther Reichle; Lutz Freitag; Philippe Monnier; Hubert van den Bergh; Georges Wagnières
Improvement of the specificity of cancer detection by autofluorescence imaging in the tracheo-bronchial tree using backscattered violet light.
Photodiagnosis and photodynamic therapy 2008;5(1):2-9.
2008: Elodie Debefve; Bernadette Pegaz; Hubert van den Bergh; Georges Wagnières; N Lange; Jean-Pierre Ballini
Video monitoring of neovessel occlusion induced by photodynamic therapy with verteporfin (Visudyne), in the CAM model.
Angiogenesis 2008;11(3):235-43.
2007: Tanja Gabrecht; Thomas Glanzmann; Lutz Freitag; Bernd-Claus Weber; Hubert van den Bergh; Georges Wagnières
Optimized autofluorescence bronchoscopy using additional backscattered red light.
Journal of biomedical optics 2007;12(6):064016.
2007: Tanja Gabrecht; Blaise Lovisa; François Borle; Georges Wagnières
Design of an endoscopic optical reference to be used for autofluorescence bronchoscopy with a commercially available diagnostic autofluorescence endoscopy (DAFE) system.
Physics in medicine and biology 2007;52(8):N163-71.
2007: Tanja Gabrecht; Snezana Andrejevic-Blant; Georges Wagnières
Blue-violet excited autofluorescence spectroscopy and imaging of normal and cancerous human bronchial tissue after formalin fixation.
Photochemistry and photobiology 2007;83(2):450-8.
2006: Pascal Uehlinger; Jean-Pierre Ballini; Hubert van den Bergh; Georges Wagnières
On the role of iron and one of its chelating agents in the production of protoporphyrin IX generated by 5-aminolevulinic acid and its hexyl ester derivative tested on an epidermal equivalent of human skin.
Photochemistry and photobiology 2006;82(4):1069-76.
2006: Bernadette Pegaz; Elodie Debefve; Jean-Pierre Ballini; Georges Wagnières; S Spaniol; Volker Albrecht; D V Scheglmann; N E Nifantiev; Hubert van den Bergh; Yvette Niamien Konan-Kouakou
Photothrombic activity of m-THPC-loaded liposomal formulations: pre-clinical assessment on chick chorioallantoic membrane model.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2006;28(1-2):134-40.
2006: Isabelle Opitz; Thorsten Krueger; Youmin Pan; Hans J Altermatt; Georges Wagnières; Hans-Beat Ris
Preclinical comparison of mTHPC and verteporfin for intracavitary photodynamic therapy of malignant pleural mesothelioma.
European surgical research. Europäische chirurgische Forschung. Recherches chirurgicales européennes 2006;38(3):333-9.
2005: Bernadette Pegaz; Elodie Debefve; François Borle; Jean-Pierre Ballini; Georges Wagnières; S Spaniol; Volker Albrecht; D Scheglmann; N E Nifantiev; Hubert van den Bergh; Y N Konan
Preclinical evaluation of a novel water-soluble chlorin E6 derivative (BLC 1010) as photosensitizer for the closure of the neovessels.
Photochemistry and photobiology 2005;81(6):1505-10.
2005: Thomas K Stepinac; Stéphane R Chamot; Elisabeth Rungger-Brändle; Pierre Ferrez; Jean-Luc Munoz; Hubert van den Bergh; Charles E Riva; Constantin J Pournaras; Georges Wagnières
Light-induced retinal vascular damage by Pd-porphyrin luminescent oxygen probes.
Investigative ophthalmology & visual science 2005;46(3):956-66.
2005: Andrea Franziska Degen Iseli; Tanja Gabrecht; Georges Wagnières; Rosmarie Caduff; Bruno Imthurn; Pius Wyss
Influence of the menstrual cycle on aminolevulinic acid induced protoporphyrin IX fluorescence in the endometrium: in vivo study.
Lasers in surgery and medicine 2005;36(3):234-7.
2004: Snezana Andrejevic-Blant; Attila L Major; Frank Lüdicke; Jean-Pierre Ballini; Georges Wagnières; Hubert van den Bergh; Marie-Françoise Pelte
Time-dependent hexaminolaevulinate induced protoporphyrin IX distribution after topical application in patients with cervical intraepithelial neoplasia: A fluorescence microscopy study.
Lasers in surgery and medicine 2004;35(4):276-83.
2004: Andrea Franziska Degen Iseli; Tanja Gabrecht; Laurent Mosimann; Mathias K Fehr; René Hornung; Viola A Schwarz; Yona Tadir; Rolf A Steiner; Georges Wagnières; Pius Wyss
Photodynamic endometrial ablation for the treatment of dysfunctional uterine bleeding: a preliminary report.
Lasers in surgery and medicine 2004;34(1):1-4.
2003: François Borle; Alexandre Radu; Charlotte Fontolliet; Hubert van den Bergh; Philippe Monnier; Georges Wagnières
Selectivity of the photosensitiser Tookad for photodynamic therapy evaluated in the Syrian golden hamster cheek pouch tumour model.
British journal of cancer 2003;89(12):2320-6.
2003: François Borle; Alexandre Radu; Philippe Monnier; Hubert van den Bergh; Georges Wagnières
Evaluation of the photosensitizer Tookad for photodynamic therapy on the Syrian golden hamster cheek pouch model: light dose, drug dose and drug-light interval effects.
Photochemistry and photobiology 2003;78(4):377-83.
2003: Thomas K Stepinac; Christian Felley; Philippe Jornod; Norbert Lange; Tanja Gabrecht; Charlotte Fontolliet; Pierre Grosjean; G vanMelle; Hubert van den Bergh; Philippe Monnier; Georges Wagnières; Gian Dorta
Endoscopic fluorescence detection of intraepithelial neoplasia in Barrett's esophagus after oral administration of aminolevulinic acid.
Endoscopy 2003;35(8):663-8.
2003: Frank Lüdicke; Tanja Gabrecht; Norbert Lange; Georges Wagnières; Hubert van den Bergh; L Berclaz; Attila L Major
Photodynamic diagnosis of ovarian cancer using hexaminolaevulinate: a preclinical study.
British journal of cancer 2003;88(11):1780-4.
2003: Pius Wyss; Rosmarie Caduff; Yona Tadir; Andrea Franziska Degen Iseli; Georges Wagnières; Viola A Schwarz; Urs Haller; Mathias K Fehr
Photodynamic endometrial ablation: morphological study.
Lasers in surgery and medicine 2003;32(4):305-9.
2003: Didier Goujon; Matthieu Zellweger; Alexandre Radu; Pierre Grosjean; Bernd-Claus Weber; Hubert van den Bergh; Philippe Monnier; Georges Wagnières
In vivo autofluorescence imaging of early cancers in the human tracheobronchial tree with a spectrally optimized system.
Journal of biomedical optics 2003;8(1):17-25.
2002: S Andrejevic Blant; Thomas Glanzmann; Jean-Pierre Ballini; Georges Wagnières; Hubert van den Bergh; Philippe Monnier
Uptake and localisation of mTHPC (Foscan) and its 14C-labelled form in normal and tumour tissues of the hamster squamous cell carcinoma model: a comparative study.
British journal of cancer 2002;87(12):1470-8.
2002: Thomas K Stepinac; Pierre Grosjean; Alain Woodtli; Philippe Monnier; Hubert van den Bergh; Georges Wagnières
Optimization of the diameter of a radial irradiation device for photodynamic therapy in the esophagus.
Endoscopy 2002;34(5):411-5.
2002: Clive Wilder-Smith; Petra Wilder-Smith; Pierre Grosjean; Hubert van den Bergh; Alain Woodtli; Philippe Monnier; Gian Dorta; Friedrich Meister; Georges Wagnières
Photoeradication of Helicobacter pylori using 5-aminolevulinic acid: preliminary human studies.
Lasers in surgery and medicine 2002;31(1):18-22.
2001: Snezana Andrejevic-Blant; Pierre Grosjean; Jean-Pierre Ballini; Georges Wagnières; Hubert van den Bergh; Charlotte Fontolliet; Philippe Monnier
Localization of tetra(m-hydroxyphenyl)chlorin (Foscan) in human healthy tissues and squamous cell carcinomas of the upper aero-digestive tract, the esophagus and the bronchi: a fluorescence microscopy study.
Journal of photochemistry and photobiology. B, Biology 2001;61(1-2):1-9.
2001: Matthieu Zellweger; Pierre Grosjean; D Goujon; Philippe Monnier; Hubert van den Bergh; Georges Wagnières
In vivo autofluorescence spectroscopy of human bronchial tissue to optimize the detection and imaging of early cancers.
Journal of biomedical optics 2001;6(1):41-51.
2000: Thomas Glanzmann; M Forrer; S Andrejevic Blant; Alain Woodtli; Pierre Grosjean; DR Braichotte; Hubert van den Bergh; Philippe Monnier; Georges Wagnières
Pharmacokinetics and pharmacodynamics of tetra(m-hydroxyphenyl)chlorin in the hamster cheek pouch tumor model: comparison with clinical measurements.
Journal of photochemistry and photobiology. B, Biology 2000;57(1):22-32.
2000: Alexandre Radu; Georges Wagnières; Hubert van den Bergh; Philippe Monnier
Photodynamic therapy of early squamous cell cancers of the esophagus.
Gastrointestinal endoscopy clinics of North America 2000;10(3):439-60.
2000: Matthieu Zellweger; Alexandre Radu; Philippe Monnier; Hubert van den Bergh; Georges Wagnières
Fluorescence pharmacokinetics of Lutetium Texaphyrin (PCI-0123, Lu-Tex) in the skin and in healthy and tumoral hamster cheek-pouch mucosa.
Journal of photochemistry and photobiology. B, Biology 2000;55(1):56-62.
2000: Snezana Andrejevic-Blant; Jean-Pierre Ballini; Hubert van den Bergh; Charlotte Fontolliet; Georges Wagnières; Philippe Monnier
Time-dependent biodistribution of tetra(m-hydroxyphenyl)chlorin and benzoporphyrin derivative monoacid ring A in the hamster model: comparative fluorescence microscopy study.
Photochemistry and photobiology 2000;71(3):333-40.
2000: P Uehlinger; Matthieu Zellweger; Georges Wagnières; Lucienne Juillerat-Jeanneret; Hubert van den Bergh; Norbert Lange
5-Aminolevulinic acid and its derivatives: physical chemical properties and protoporphyrin IX formation in cultured cells.
Journal of photochemistry and photobiology. B, Biology 2000;54(1):72-80.
1999: Matthieu Zellweger; Pierre Grosjean; Philippe Monnier; Hubert van den Bergh; Georges Wagnières
Stability of the fluorescence measurement of Foscan in the normal human oral cavity as an indicator of its content in early cancers of the esophagus and the bronchi.
Photochemistry and photobiology 1999;69(5):605-10.
1999: Norbert Lange; Patrice Jichlinski; Matthieu Zellweger; M Forrer; A Marti; L Guillou; Pavel Kucera; Georges Wagnières; Hubert van den Bergh
Photodetection of early human bladder cancer based on the fluorescence of 5-aminolaevulinic acid hexylester-induced protoporphyrin IX: a pilot study.
British journal of cancer 1999;80(1-2):185-93.
1998: Georges Wagnières; W M Star; B C Wilson
In vivo fluorescence spectroscopy and imaging for oncological applications.
Photochemistry and photobiology 1998;68(5):603-32.
1998: A Kienle; Thomas Glanzmann; Georges Wagnières; H Bergh
Investigation of two-layered turbid media with time-resolved reflectance.
Applied optics 1998;37(28):6852-62.
1998: Thomas Glanzmann; C Hadjur; Matthieu Zellweger; P Grosiean; M Forrer; Jean-Pierre Ballini; Philippe Monnier; Hubert van den Bergh; C K Lim; Georges Wagnières
Pharmacokinetics of tetra(m-hydroxyphenyl)chlorin in human plasma and individualized light dosimetry in photodynamic therapy.
Photochemistry and photobiology 1998;67(5):596-602.
1997: S A Blant; J F Theumann; M Forrer; Georges Wagnières; Hubert van den Bergh; Philippe Monnier
Wavelength-dependent effect of tetra(m-hydroxyphenyl)chlorin for photodynamic therapy in an 'early' squamous cell carcinoma model.
Lasers in medical science 1997;12(3):269-73.
1997: J Mizeret; Georges Wagnières; Thomas K Stepinac; Hubert van den Bergh
Endoscopic tissue characterization by frequency-domain fluorescence lifetime imaging (FD-FLIM).
Lasers in medical science 1997;12(3):209-17.
1997: Georges Wagnières; S Cheng; Matthieu Zellweger; N Utke; DR Braichotte; Jean-Pierre Ballini; Hubert van den Bergh
An optical phantom with tissue-like properties in the visible for use in PDT and fluorescence spectroscopy.
Physics in medicine and biology 1997;42(7):1415-26.
1997: C Hadjur; Georges Wagnières; F Ihringer; Philippe Monnier; Hubert van den Bergh
Production of the free radicals O2.- and .OH by irradiation of the photosensitizer zinc(II) phthalocyanine.
Journal of photochemistry and photobiology. B, Biology 1997;38(2-3):196-202.
1997: JF Savary; Philippe Monnier; Charlotte Fontolliet; J Mizeret; Georges Wagnières; DR Braichotte; Hubert van den Bergh
Photodynamic therapy for early squamous cell carcinomas of the esophagus, bronchi, and mouth with m-tetra (hydroxyphenyl) chlorin.
Archives of otolaryngology--head & neck surgery 1997;123(2):162-8.
1997: Snezana Andrejevic-Blant; C Hadjur; Jean-Pierre Ballini; Georges Wagnières; Charlotte Fontolliet; Hubert van den Bergh; Philippe Monnier
Photodynamic therapy of early squamous cell carcinoma with tetra(m-hydroxyphenyl)chlorin: optimal drug-light interval.
British journal of cancer 1997;76(8):1021-8.
1997: R Bays; Georges Wagnières; D Robert; J F Theumann; A Vitkin; JF Savary; Philippe Monnier; Hubert van den Bergh
Three-dimensional optical phantom and its application in photodynamic therapy.
Lasers in surgery and medicine 1997;21(3):227-34.
1997: Patrice Jichlinski; M Forrer; J Mizeret; Thomas Glanzmann; DR Braichotte; Georges Wagnières; G Zimmer; L Guillou; Franz R Schmidlin; P Graber; Hubert van den Bergh; Hans-Jürg Leisinger
Clinical evaluation of a method for detecting superficial surgical transitional cell carcinoma of the bladder by light-induced fluorescence of protoporphyrin IX following the topical application of 5-aminolevulinic acid: preliminary results.
Lasers in surgery and medicine 1997;20(4):402-8.
1997: R Bays; Georges Wagnières; D Robert; DR Braichotte; JF Savary; Philippe Monnier; Hubert van den Bergh
Light dosimetry for photodynamic therapy in the esophagus.
Lasers in surgery and medicine 1997;20(3):290-303.
1997: Patrice Jichlinski; Georges Wagnières; M Forrer; J Mizeret; L Guillou; M Oswald; Franz R Schmidlin; P Graber; Hubert van den Bergh; Hans-Jürg Leisinger
Clinical assessment of fluorescence cytoscopy during transurethral bladder resection in superficial bladder cancer.
Urological research 1997;25 Suppl 1():S3-6.
1996: S A Blant; A Woodtli; Georges Wagnières; Charlotte Fontolliet; Hubert van den Bergh; Philippe Monnier
In vivo fluence rate effect in photodynamic therapy of early cancers with tetra(m-hydroxyphenyl)chlorin.
Photochemistry and photobiology 1996;64(6):963-8.
1996: S Andrejevic; JF Savary; Philippe Monnier; Charlotte Fontolliet; DR Braichotte; Georges Wagnières; Hubert van den Bergh
Measurements by fluorescence microscopy of the time-dependent distribution of meso-tetra-hydroxyphenylchlorin in healthy tissues and chemically induced "early" squamous cell carcinoma of the Syrian hamster cheek pouch.
Journal of photochemistry and photobiology. B, Biology 1996;36(2):143-51.
1995: DR Braichotte; Georges Wagnières; R Bays; Philippe Monnier; Hubert van den Bergh
Clinical pharmacokinetic studies of photofrin by fluorescence spectroscopy in the oral cavity, the esophagus, and the bronchi.
Cancer 1995;75(11):2768-78.
1994: S Folli; P Westermann; DR Braichotte; André Pèlegrin; Georges Wagnières; Hubert van den Bergh; Jean-Pierre Mach
Antibody-indocyanin conjugates for immunophotodetection of human squamous cell carcinoma in nude mice.
Cancer research 1994;54(10):2643-9.
1992: S Folli; Georges Wagnières; André Pèlegrin; J M Calmes; DR Braichotte; Franz Buchegger; Y Chalandon; N Hardman; C Heusser; J C Givel
Immunophotodiagnosis of colon carcinomas in patients injected with fluoresceinated chimeric antibodies against carcinoembryonic antigen.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(17):7973-7.
1991: André Pèlegrin; S Folli; Franz Buchegger; Jean-Pierre Mach; Georges Wagnières; Hubert van den Bergh
Antibody-fluorescein conjugates for photoimmunodiagnosis of human colon carcinoma in nude mice.
Cancer 1991;67(10):2529-37.