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Alan Wahl

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Julie A McEarchern; Ezogelin Oflazoglu; Leigh Francisco; Charlotte F McDonagh; Kristine A Gordon; Ivan Stone; Kerry Klussman; Eileen Turcott; Nico van Rooijen; Paul Carter; Iqbal Grewal; Alan F Wahl; Che-Leung Law
Engineered anti-CD70 antibody with multiple effector functions exhibits in vitro and in vivo antitumor activities.
M. Sutherland; Russell J Sanderson; Kristine A Gordon; Jamie Andreyka; Charles G Cerveny; Changpu Yu; Timothy S Lewis; Damon L Meyer; Roger F Zabinski; Svetlana O Doronina; Peter D Senter; Che-Leung Law; Alan F Wahl
Lysosomal trafficking and cysteine protease metabolism confer target-specific cytotoxicity by peptide-linked anti-CD30-auristatin conjugates.
Che-Leung Law; Kristine A Gordon; Brian E Toki; Andrew K Yamane; Michelle A Hering; Charles G Cerveny; Joseph Petroziello; Maureen C Ryan; Leia Smith; Ronald Simon; Guido Sauter; Ezogelin Oflazoglu; Svetlana O Doronina; Damon L Meyer; Joseph A Francisco; Paul Carter; Peter D Senter; John A Copland; Christopher G Wood; Alan F Wahl
Lymphocyte activation antigen CD70 expressed by renal cell carcinoma is a potential therapeutic target for anti-CD70 antibody-drug conjugates.

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All Publications

2007: Julie A McEarchern; Ezogelin Oflazoglu; Leigh Francisco; Charlotte F McDonagh; Kristine A Gordon; Ivan Stone; Kerry Klussman; Eileen Turcott; Nico van Rooijen; Paul Carter; Iqbal Grewal; Alan F Wahl; Che-Leung Law
Engineered anti-CD70 antibody with multiple effector functions exhibits in vitro and in vivo antitumor activities.
Blood 2007;109(3):1185-92.
2006: M. Sutherland; Russell J Sanderson; Kristine A Gordon; Jamie Andreyka; Charles G Cerveny; Changpu Yu; Timothy S Lewis; Damon L Meyer; Roger F Zabinski; Svetlana O Doronina; Peter D Senter; Che-Leung Law; Alan F Wahl
Lysosomal trafficking and cysteine protease metabolism confer target-specific cytotoxicity by peptide-linked anti-CD30-auristatin conjugates.
The Journal of biological chemistry 2006;281(15):10540-7.
2006: Che-Leung Law; Kristine A Gordon; Brian E Toki; Andrew K Yamane; Michelle A Hering; Charles G Cerveny; Joseph Petroziello; Maureen C Ryan; Leia Smith; Ronald Simon; Guido Sauter; Ezogelin Oflazoglu; Svetlana O Doronina; Damon L Meyer; Joseph A Francisco; Paul Carter; Peter D Senter; John A Copland; Christopher G Wood; Alan F Wahl
Lymphocyte activation antigen CD70 expressed by renal cell carcinoma is a potential therapeutic target for anti-CD70 antibody-drug conjugates.
Cancer research 2006;66(4):2328-37.
2006: Svetlana O Doronina; Brian A Mendelsohn; Tim D Bovee; Charles G Cerveny; Stephen C Alley; Damon L Meyer; Ezogelin Oflazoglu; Brian E Toki; Russell J Sanderson; Roger F Zabinski; Alan F Wahl; Peter D Senter
Enhanced activity of monomethylauristatin F through monoclonal antibody delivery: effects of linker technology on efficacy and toxicity.
Bioconjugate chemistry 2006;17(1):114-24.
2005: Che-Leung Law; Kristine A Gordon; John Collier; Kerry Klussman; Julie A McEarchern; Charles G Cerveny; Bruce J Mixan; Wyne P Lee; Zhonghau Lin; Patricia Valdez; Alan F Wahl; Iqbal Grewal
Preclinical antilymphoma activity of a humanized anti-CD40 monoclonal antibody, SGN-40.
Cancer research 2005;65(18):8331-8.
2005: Charles G Cerveny; Che-Leung Law; R S McCormick; J S Lenox; Kevin J Hamblett; Lori Westendorf; Andrew K Yamane; Joseph Petroziello; Joseph A Francisco; Alan F Wahl
Signaling via the anti-CD30 mAb SGN-30 sensitizes Hodgkin's disease cells to conventional chemotherapeutics.
Leukemia 2005;19(9):1648-55.
2005: Russell J Sanderson; Michelle A Hering; Stephanie F James; Michael M C Sun; Svetlana O Doronina; Anthony W Siadak; Peter D Senter; Alan F Wahl
In vivo drug-linker stability of an anti-CD30 dipeptide-linked auristatin immunoconjugate.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(2 Pt 1):843-52.
2004: Che-Leung Law; Charles G Cerveny; Kristine A Gordon; Kerry Klussman; Bruce J Mixan; Dana F Chace; Damon L Meyer; Svetlana O Doronina; Clay B Siegall; Joseph A Francisco; Peter D Senter; Alan F Wahl
Efficient elimination of B-lineage lymphomas by anti-CD20-auristatin conjugates.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(23):7842-51.
2004: Kerry Klussman; Bruce J Mixan; Charles G Cerveny; Damon L Meyer; Peter D Senter; Alan F Wahl
Secondary mAb--vcMMAE conjugates are highly sensitive reporters of antibody internalization via the lysosome pathway.
Bioconjugate chemistry 2004;15(4):765-73.
2003: Joseph A Francisco; Charles G Cerveny; Damon L Meyer; Bruce J Mixan; Kerry Klussman; Dana F Chace; Starr X Rejniak; Kristine A Gordon; Ron DeBlanc; Brian E Toki; Che-Leung Law; Svetlana O Doronina; Clay B Siegall; Peter D Senter; Alan F Wahl
cAC10-vcMMAE, an anti-CD30-monomethyl auristatin E conjugate with potent and selective antitumor activity.
Blood 2003;102(4):1458-65.
2003: Svetlana O Doronina; Brian E Toki; Michael Y Torgov; Brian A Mendelsohn; Charles G Cerveny; Dana F Chace; Ron L DeBlanc; R Patrick Gearing; Tim D Bovee; Clay B Siegall; Joseph A Francisco; Alan F Wahl; Damon L Meyer; Peter D Senter
Development of potent monoclonal antibody auristatin conjugates for cancer therapy.
Nature biotechnology 2003;21(7):778-84.
2002: Alan F Wahl; Kerry Klussman; Jennifer D Thompson; Judy H Chen; Leigh V Francisco; Grant Risdon; Dana F Chace; Clay B Siegall; Joseph A Francisco
The anti-CD30 monoclonal antibody SGN-30 promotes growth arrest and DNA fragmentation in vitro and affects antitumor activity in models of Hodgkin's disease.
Cancer research 2002;62(13):3736-42.
2002: Brian E Toki; Charles G Cerveny; Alan F Wahl; Peter D Senter
Protease-mediated fragmentation of p-amidobenzyl ethers: a new strategy for the activation of anticancer prodrugs.
The Journal of organic chemistry 2002;67(6):1866-72.
2001: Alan F Wahl; PM Wallace
Oncostatin M in the anti-inflammatory response.
Annals of the rheumatic diseases 2001;60 Suppl 3():iii75-80.
2001: Peter D Senter; Kevin S Beam; Bruce J Mixan; Alan F Wahl
Identification and activities of human carboxylesterases for the activation of CPT-11, a clinically approved anticancer drug.
Bioconjugate chemistry 2001;12(6):1074-80.
2001: Alan F Wahl; K L Donaldson; Bruce J Mixan; P A Trail; Clay B Siegall
Selective tumor sensitization to taxanes with the mAb-drug conjugate cBR96-doxorubicin.
International journal of cancer. Journal international du cancer 2001;93(4):590-600.
2001: Alan F Wahl; K L Donaldson
Centrifugal elutriation to obtain synchronous populations of cells.
Current protocols in cell biology / editorial board, Juan S. Bonifacino ... [et al.] 2001;Chapter 8():Unit 8.5.
2000: Joseph A Francisco; K L Donaldson; Dana F Chace; Clay B Siegall; Alan F Wahl
Agonistic properties and in vivo antitumor activity of the anti-CD40 antibody SGN-14.
Cancer research 2000;60(12):3225-31.
1999: Andy McShea; Alan F Wahl; Mark A. Smith
Re-entry into the cell cycle: a mechanism for neurodegeneration in Alzheimer disease.
Medical hypotheses 1999;52(6):525-7.
1999: PM Wallace; John F MacMaster; Katherine A Rouleau; T J Brown; JK Loy; KL Donaldson; Alan F Wahl
Regulation of inflammatory responses by oncostatin M.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(9):5547-55.
1997: Andy McShea; P L Harris; K R Webster; Alan F Wahl; Mark A. Smith
Abnormal expression of the cell cycle regulators P16 and CDK4 in Alzheimer's disease.
The American journal of pathology 1997;150(6):1933-9.
1997: Mary C Horne; KL Donaldson; G L Goolsby; D Tran; M Mulheisen; Johannes Hell; Alan F Wahl
Cyclin G2 is up-regulated during growth inhibition and B cell antigen receptor-mediated cell cycle arrest.
The Journal of biological chemistry 1997;272(19):12650-61.
1997: KL Donaldson; Andy McShea; Alan F Wahl
Separation by counterflow centrifugal elutriation and analysis of T- and B-lymphocytic cell lines in progressive stages of cell division cycle.
Journal of immunological methods 1997;203(1):25-33.
1996: N Malik; BW Greenfield; Alan F Wahl; Peter Kiener
Activation of human monocytes through CD40 induces matrix metalloproteinases.
Journal of immunology (Baltimore, Md. : 1950) 1996;156(10):3952-60.
1996: Mary C Horne; G L Goolsby; K L Donaldson; D Tran; M Neubauer; Alan F Wahl
Cyclin G1 and cyclin G2 comprise a new family of cyclins with contrasting tissue-specific and cell cycle-regulated expression.
The Journal of biological chemistry 1996;271(11):6050-61.
1996: Alan F Wahl; K L Donaldson; Craig R Fairchild; F Y Lee; S A Foster; G W Demers; Denise A Galloway
Loss of normal p53 function confers sensitization to Taxol by increasing G2/M arrest and apoptosis.
Nature medicine 1996;2(1):72-9.
1995: Peter Kiener; P Moran-Davis; B M Rankin; Alan F Wahl; Alejandro Aruffo; Diane L Hollenbaugh
Stimulation of CD40 with purified soluble gp39 induces proinflammatory responses in human monocytes.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(10):4917-25.
1995: G L Schieven; Alan F Wahl; S Myrdal; LS Grosmaire; Jeffrey A Ledbetter
Lineage-specific induction of B cell apoptosis and altered signal transduction by the phosphotyrosine phosphatase inhibitor bis(maltolato)oxovanadium(IV).
The Journal of biological chemistry 1995;270(35):20824-31.
1994: K L Donaldson; G L Goolsby; Peter Kiener; Alan F Wahl
Activation of p34cdc2 coincident with taxol-induced apoptosis.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1994;5(10):1041-50.
1994: K L Donaldson; G L Goolsby; Alan F Wahl
Cytotoxicity of the anticancer agents cisplatin and taxol during cell proliferation and the cell cycle.
International journal of cancer. Journal international du cancer 1994;57(6):847-55.