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Irving Wainer

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Co-Publications
Name
35
Moaddel, Ruin
16
Jozwiak, Krzysztof
9
Yamaguchi, Rika
9
Markoglou, Nektaria
9
Ducharme, Murray
6
Patel, Sharvil
6
Siluk, Danuta
5
Ravichandran, Sarangan
5
Bernier, Michel
4
Bhargava, Pankaj
4
Di Marco, Marika Pasternyk
4
Kellar, Kenneth
4
Leyland-Jones, Brian
4
O'Neil, WM
4
Lloyd, DK

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Publications

TOP 3
Alvarez Covadonga; Wainer Irving W
Development of an automatic solid phase extraction and liquid chromatography mass spectrometry method by using a monolithic column for the analysis of Cyclosporin A in human plasma.
Arias Hugo R; Gumilar Fernanda; Rosenberg Avraham; Targowska-Duda Katarzyna M; Feuerbach Dominik; Jozwiak Krzysztof; Moaddel Ruin; Wainer Irving W; Bouzat Cecilia
Interaction of bupropion with muscle-type nicotinic acetylcholine receptors in different conformational states.
Kim Hee Seung; Siluk Danuta; Wainer Irving W
Quantitative determination of fenoterol and fenoterol derivatives in rat plasma using on-line immunoextraction and liquid chromatography/mass spectrometry.

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All Publications

2009: Alvarez Covadonga; Wainer Irving W
Development of an automatic solid phase extraction and liquid chromatography mass spectrometry method by using a monolithic column for the analysis of Cyclosporin A in human plasma.
Talanta 2009;79(2):280-3.
2009: Arias Hugo R; Gumilar Fernanda; Rosenberg Avraham; Targowska-Duda Katarzyna M; Feuerbach Dominik; Jozwiak Krzysztof; Moaddel Ruin; Wainer Irving W; Bouzat Cecilia
Interaction of bupropion with muscle-type nicotinic acetylcholine receptors in different conformational states.
Biochemistry 2009;48(21):4506-18.
2009: Kim Hee Seung; Siluk Danuta; Wainer Irving W
Quantitative determination of fenoterol and fenoterol derivatives in rat plasma using on-line immunoextraction and liquid chromatography/mass spectrometry.
Journal of chromatography. A 2009;1216(16):3526-32.
2009: Wang Yan; Xie Yi; Bernier Michel; Wainer Irving W
Determination of free and protein-bound glutathione in HepG2 cells using capillary electrophoresis with laser-induced fluorescence detection.
Journal of chromatography. A 2009;1216(16):3533-7.
2009: Cannazza Giuseppe; Jozwiak Krzysztof; Parenti Carlo; Braghiroli Daniela; Carrozzo Marina M; Puia Giulia; Losi Gabriele; Baraldi Mario; Lindner Wolfgang; Wainer Irving W
A novel class of allosteric modulators of AMPA/Kainate receptors.
Bioorganic & medicinal chemistry letters 2009;19(4):1254-7.
2009: Moaddel Ruin; Wainer Irving W
The preparation and development of cellular membrane affinity chromatography columns.
Nature protocols 2009;4(2):197-205.
2008: Kitabatake T; Moaddel R; Cole R; Gandhari M; Frazier C; Hartenstein J; Rosenberg A; Bernier M; Wainer I W
Characterization of a multiple ligand-gated ion channel cellular membrane affinity chromatography column and identification of endogenously expressed receptors in astrocytoma cell lines.
Analytical chemistry 2008;80(22):8673-80.
2008: Jozwiak Krzysztof; Moaddel Ruin; Ravichandran Sarangan; Plazinska Anita; Kozak Joanna; Patel Sharvil; Yamaguchi Rika; Wainer Irving W
Exploring enantiospecific ligand-protein interactions using cellular membrane affinity chromatography: chiral recognition as a dynamic process.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2008;875(1):200-7.
2008: Siluk Danuta; Kim Hee Seung; Cole Tyler; Wainer Irving W
HPLC-electrospray mass spectrometric assay for the determination of (R,R)-fenoterol in rat plasma.
Journal of pharmaceutical and biomedical analysis 2008;48(3):960-4.
2008: Marszall M P; Moaddel R; Kole S; Gandhari M; Bernier M; Wainer I W
Ligand and protein fishing with heat shock protein 90 coated magnetic beads.
Analytical chemistry 2008;80(19):7571-5.
2008: Maciuk Alexandre; Moaddel Ruin; Haginaka Jun; Wainer Irving W
Screening of tobacco smoke condensate for nicotinic acetylcholine receptor ligands using cellular membrane affinity chromatography columns and missing peak chromatography.
Journal of pharmaceutical and biomedical analysis 2008;48(2):238-46.
2008: Bhatia P; Kolinski M; Moaddel R; Jozwiak K; Wainer I W
Determination and modelling of stereoselective interactions of ligands with drug transporters: a key dimension in the understanding of drug disposition.
Xenobiotica; the fate of foreign compounds in biological systems 2008;38(7-8):656-75.
2008: Kim Hee Seung; Wainer Irving W
Rapid analysis of the interactions between drugs and human serum albumin (HSA) using high-performance affinity chromatography (HPAC).
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2008;870(1):22-6.
2008: Marszall Michal P; Moaddel Ruin; Jozwiak Krzysztof; Bernier Michel; Wainer Irving W
Initial synthesis and characterization of an immobilized heat shock protein 90 column for online determination of binding affinities.
Analytical biochemistry 2008;373(2):313-21.
2008: Moaddel Ruin; Oliveira Regina V; Kimura Tomoko; Hyppolite Patrick; Juhaszova Magdalena; Xiao Yingxian; Kellar Kenneth J; Bernier Michel; Wainer Irving W
Initial synthesis and characterization of an alpha7 nicotinic receptor cellular membrane affinity chromatography column: effect of receptor subtype and cell type.
Analytical chemistry 2008;80(1):48-54.
2007: Jozwiak Krzysztof; Ravichandran Sarangan; Collins Jack R; Moaddel Ruin; Wainer Irving W
Interaction of noncompetitive inhibitors with the alpha3beta2 nicotinic acetylcholine receptor investigated by affinity chromatography and molecular docking.
Journal of medicinal chemistry 2007;50(24):6279-83.
2007: Siluk Danuta; Mager Donald E; Gronich Naomi; Abernethy Darrell; Wainer Irving W
HPLC-atmospheric pressure chemical ionization mass spectrometric method for enantioselective determination of R,S-propranolol and R,S-hyoscyamine in human plasma.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2007;859(2):213-21.
2007: Oliveira Regina V; Onorato Joelle M; Siluk Danuta; Walko Christine M; Lindley Celeste; Wainer Irving W
Enantioselective liquid chromatography-mass spectrometry assay for the determination of ifosfamide and identification of the N-dechloroethylated metabolites of ifosfamide in human plasma.
Journal of pharmaceutical and biomedical analysis 2007;45(2):295-303.
2007: Moaddel Ruin; Jozwiak Krzysztof; Wainer Irving W
Allosteric modifiers of neuronal nicotinic acetylcholine receptors: new methods, new opportunities.
Medicinal research reviews 2007;27(5):723-53.
2007: Moaddel R; Ravichandran S; Bighi F; Yamaguchi R; Wainer I W
Pharmacophore modelling of stereoselective binding to the human organic cation transporter (hOCT1).
British journal of pharmacology 2007;151(8):1305-14.
2007: Siluk Danuta; Oliveira Regina V; Esther-Rodriguez-Rosas Maria; Ling Shari; Bos Angelo; Ferrucci Luigi; Wainer Irving W
A validated liquid chromatography method for the simultaneous determination of vitamins A and E in human plasma.
Journal of pharmaceutical and biomedical analysis 2007;44(4):1001-7.
2007: Moaddel R; Marszall M P; Bighi F; Yang Q; Duan X; Wainer I W
Automated ligand fishing using human serum albumin-coated magnetic beads.
Analytical chemistry 2007;79(14):5414-7.
2007: Jozwiak Krzysztof; Khalid Chakir; Tanga Mary J; Berzetei-Gurske Ilona; Jimenez Lucita; Kozocas Joseph A; Woo Anthony; Zhu Weizhong; Xiao Rui-Ping; Abernethy Darrell R; Wainer Irving W
Comparative molecular field analysis of the binding of the stereoisomers of fenoterol and fenoterol derivatives to the beta2 adrenergic receptor.
Journal of medicinal chemistry 2007;50(12):2903-15.
2007: Moaddel Ruin; Calleri Enrica; Massolini Gabriella; Frazier Chester R; Wainer Irving W
The synthesis and initial characterization of an immobilized purinergic receptor (P2Y1) liquid chromatography stationary phase for online screening.
Analytical biochemistry 2007;364(2):216-8.
2007: Rodriguez-Rosas Maria Esther; Lofwall Michelle R; Strain Eric C; Siluk Danuta; Wainer Irving W
Simultaneous determination of buprenorphine, norbuprenorphine and the enantiomers of methadone and its metabolite (EDDP) in human plasma by liquid chromatography/mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2007;850(1-2):538-43.
2007: Moaddel Ruin; Wainer Irving W
Conformational mobility of immobilized proteins.
Journal of pharmaceutical and biomedical analysis 2007;43(2):399-406.
2006: Margaryan Armenak; Moaddel Ruin; Aldrich Jeffrey R; Tsuruda Jennifer M; Chen Angela M; Leal Walter S; Wainer Irving W
Synthesis of an immobilized Bombyx mori pheromone-binding protein liquid chromatography stationary phase.
Talanta 2006;70(4):752-5.
2006: Sambe Haruyo; Hoshina Kaori; Moaddel Ruin; Wainer Irving W; Haginaka Jun
Uniformly-sized, molecularly imprinted polymers for nicotine by precipitation polymerization.
Journal of chromatography. A 2006;1134(1-2):88-94.
2006: Beigi Farideh; Bertucci Carlo; Zhu Weizhong; Chakir Khalid; Wainer Irving W; Xiao Rui-Ping; Abernethy Darrell R
Enantioselective separation and online affinity chromatographic characterization of R,R- and S,S-fenoterol.
Chirality 2006;18(10):822-7.
2006: Kim Hee Seung; Wainer Irving W
On-line drug metabolism in capillary electrophoresis. 1. Glucuronidation using rat liver microsomes.
Analytical chemistry 2006;78(20):7071-7.
2006: Moaddel Ruin; Hamid Rachid; Patel Sharvil; Bullock Peter L; Wainer Irving W
Identification of P-glycoprotein substrates using open tubular chromatography on an immobilized P-glycoprotein column: Comparison of chromatographic results with Caco-2 permeability.
Analytica chimica acta 2006;578(1):25-30.
2006: Jozwiak Krzysztof; Moaddel Ruin; Yamaguchi Rika; Maciuk Alexandre; Wainer Irving W
Non-competitive inhibitory activities of morphinan and morphine derivatives at the alpha 3 beta 4 Neuronal nicotinic acetylcholine receptor determined using nonlinear chromatography and chemometric techniques.
Pharmaceutical research 2006;23(9):2175-82.
2006: Cardoso Carmem L; Lima Virginia V; Zottis Aderson; Oliva Glaucius; Andricopulo Adriano D; Wainer Irving W; Moaddel Ruin; Cass Quezia B
Development and characterization of an immobilized enzyme reactor (IMER) based on human glyceraldehyde-3-phosphate dehydrogenase for on-line enzymatic studies.
Journal of chromatography. A 2006;1120(1-2):151-7.
2006: Moaddel Ruin; Wainer Irving W
Development of immobilized membrane-based affinity columns for use in the online characterization of membrane bound proteins and for targeted affinity isolations.
Analytica chimica acta 2006;564(1):97-105.
2006: Bernstein Mark L; Devidas Meenakshi; Lafreniere Dominique; Souid Abdul-Kader; Meyers Paul A; Gebhardt Mark; Stine Kimo; Nicholas Richard; Perlman Elizabeth J; Dubowy Ronald; Wainer Irving W; Dickman Paul S; Link Michael P; Goorin Allen; Grier Holcombe E;
Intensive therapy with growth factor support for patients with Ewing tumor metastatic at diagnosis: Pediatric Oncology Group/Children's Cancer Group Phase II Study 9457--a report from the Children's Oncology Group.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2006;24(1):152-9.
2005: Moaddel R; Patel S; Jozwiak K; Yamaguchi R; Ho P C; Wainer I W
Enantioselective binding to the human organic cation transporter-1 (hOCT1) determined using an immobilized hOCT1 liquid chromatographic stationary phase.
Chirality 2005;17(8):501-6.
2005: Kim Hee Seung; Wainer Irving W
The covalent immobilization of microsomal uridine diphospho-glucuronosyltransferase (UDPGT): initial synthesis and characterization of an UDPGT immobilized enzyme reactor for the on-line study of glucuronidation.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2005;823(2):158-66.
2005: Moaddel Ruin; Jozwiak Krzysztof; Yamaguchi Rika; Wainer Irving W
Direct chromatographic determination of dissociation rate constants of ligand-receptor complexes: assessment of the interaction of noncompetitive inhibitors with an immobilized nicotinic acetylcholine receptor-based liquid chromatography stationary phase.
Analytical chemistry 2005;77(16):5421-6.
2005: Moaddel Ruin; Price Gerry B; Juteau Jean-Marc; Leffak Michael; Wainer Irving W
The synthesis and initial characterization of an immobilized DNA unwinding element binding (DUE-B) protein chromatographic stationary phase.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2005;820(2):197-203.
2005: Rodriguez-Rosas Maria Esther; Medrano Juan G; Epstein David H; Moolchan Eric T; Preston Kenzie L; Wainer Irving W
Determination of total and free concentrations of the enantiomers of methadone and its metabolite (2-ethylidene-1,5-dimethyl-3,3-diphenyl-pyrrolidine) in human plasma by enantioselective liquid chromatography with mass spectrometric detection.
Journal of chromatography. A 2005;1073(1-2):237-48.
2005: Jozwiak Krzysztof; Moaddel Ruin; Yamaguchi Rika; Ravichandran Sarangan; Collins Jack R; Wainer Irving W
Qualitative assessment of IC50 values of inhibitors of the neuronal nicotinic acetylcholine receptor using a single chromatographic experiment and multivariate cluster analysis.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2005;819(1):169-74.
2005: Moaddel R; Yamaguchi R; Ho P C; Patel S; Hsu C-P; Subrahmanyam V; Wainer I W
Development and characterization of an immobilized human organic cation transporter based liquid chromatographic stationary phase.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2005;818(2):263-8.
2005: Moaddel Ruin; Jozwiak Krzysztof; Whittington Kevin; Wainer Irving W
Conformational mobility of immobilized alpha3beta2, alpha3beta4, alpha4beta2, and alpha4beta4 nicotinic acetylcholine receptors.
Analytical chemistry 2005;77(3):895-901.
2005: Strigo Irina A; Duncan Gary H; Bushnell M Catherine; Boivin Michel; Wainer Irving; Rodriguez Rosas M Esther; Persson Jan
The effects of racemic ketamine on painful stimulation of skin and viscera in human subjects.
Pain 2005;113(3):255-64.
2004: Sarkar Tarun K; Basak Sankar; Wainer Irving; Moaddel Ruin; Yamaguchi Rika; Jozwiak Krzysztof; Chen Hui-Ting; Lin Chun-Cheng
Coaxing a pyridine nucleus to give up its aromaticity: synthesis and pharmacological characterization of novel conformationally restricted analogues of nicotine and anabasine.
Journal of medicinal chemistry 2004;47(27):6691-701.
2004: Beigi Farideh; Chakir Khalid; Xiao Rui-Ping; Wainer Irving W
G-protein-coupled receptor chromatographic stationary phases. 2. Ligand-induced conformational mobility in an immobilized beta2-adrenergic receptor.
Analytical chemistry 2004;76(24):7187-93.
2004: Moaddel Ruin; Jozwiak Krzysztof; Yamaguchi Rika; Cobello Christopher; Whittington Kevin; Sarkar Tarun K; Basak Sankar; Wainer Irving W
On-line screening of conformationally constrained nicotines and anabasines for agonist activity at the alpha3beta4- and alpha4beta2-nicotinic acetylcholine receptors using immobilized receptor-based liquid chromatographic stationary phases.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2004;813(1-2):235-40.
2004: Wainer Irving W
Finding time for allosteric interactions.
Nature biotechnology 2004;22(11):1376-7.
2004: Calleri E; Marrubini G; Massolini G; Lubda D; de Fazio S S; Furlanetto S; Wainer I W; Manzo L; Caccialanza G
Development of a chromatographic bioreactor based on immobilized beta-glucuronidase on monolithic support for the determination of dextromethorphan and dextrorphan in human urine.
Journal of pharmaceutical and biomedical analysis 2004;35(5):1179-89.
2004: Williams Marion L; Mager Donald E; Parenteau Heli; Gudi Girish; Tracy Timothy S; Mulheran Mike; Wainer Irving W
Effects of protein calorie malnutrition on the pharmacokinetics of ketamine in rats.
Drug metabolism and disposition: the biological fate of chemicals 2004;32(8):786-93.
2004: Di Marco Marika Pasternyk; Chen John; Wainer Irving W; Ducharme Murray P
A population pharmacokinetic-metabolism model for individualizing ciprofloxacin therapy in ophthalmology.
Therapeutic drug monitoring 2004;26(4):401-7.
2004: Jozwiak Krzysztof; Ravichandran Sarangan; Collins Jack R; Wainer Irving W
Interaction of noncompetitive inhibitors with an immobilized alpha3beta4 nicotinic acetylcholine receptor investigated by affinity chromatography, quantitative-structure activity relationship analysis, and molecular docking.
Journal of medicinal chemistry 2004;47(16):4008-21.
2004: Markoglou Nektaria; Hsuesh Ruth; Wainer Irving W
Immobilized enzyme reactors based upon the flavoenzymes monoamine oxidase A and B.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2004;804(2):295-302.
2004: Moaddel Ruin; Bullock Peter L; Wainer Irving W
Development and characterization of an open tubular column containing immobilized P-glycoprotein for rapid on-line screening for P-glycoprotein substrates.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2004;799(2):255-63.
2004: Williams M L; Torres-Duarte A; Brant L J; Bhargava P; Marshall J; Wainer Irving W
The relationship between a urinary cachectic factor and weight loss in advanced cancer patients.
Cancer investigation 2004;22(6):866-70.
2003: Jozwiak Krzysztof; Hernandez Susan C; Kellar Kenneth J; Wainer Irving W
Enantioselective interactions of dextromethorphan and levomethorphan with the alpha 3 beta 4-nicotinic acetylcholine receptor: comparison of chromatographic and functional data.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2003;797(1-2):373-9.
2003: Rosas Maria Esther Rodriguez; Preston Kenzie L; Epstein David H; Moolchan Eric T; Wainer Irving W
Quantitative determination of the enantiomers of methadone and its metabolite (EDDP) in human saliva by enantioselective liquid chromatography with mass spectrometric detection.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2003;796(2):355-70.
2003: Beigi Farideh; Wainer Irving W
Syntheses of immobilized G protein-coupled receptor chromatographic stationary phases: characterization of immobilized mu and kappa opioid receptors.
Analytical chemistry 2003;75(17):4480-5.
2003: Woodland Cindy; Koren Gideon; Wainer Irving W; Batist Gerry; Ito Shinya
Verapamil metabolites: potential P-glycoprotein-mediated multidrug resistance reversal agents.
Canadian journal of physiology and pharmacology 2003;81(8):800-5.
2003: Rodriguez Rosas Maria Esther; Patel Sharvil; Wainer Irving W
Determination of the enantiomers of ketamine and norketamine in human plasma by enantioselective liquid chromatography-mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2003;794(1):99-108.
2003: Gonin Joyce M; Nguyen Hien; Gonin René; Sarna Avina; Michels Anne; Masri-Imad Faye; Bommareddy Geeta; Chassaing Christophe; Wainer Irving; Loya Asif; Cary Douglas; Barker Lew F; Assefi Ali; Greenspan Robert; Mahoney David; Wilcox Christopher S
Controlled trials of very high dose folic acid, vitamins B12 and B6, intravenous folinic acid and serine for treatment of hyperhomocysteinemia in ESRD.
Journal of nephrology 2003;16(4):522-34.
2003: Bartolini Manuela; Andrisano Vincenza; Wainer Irving W
Development and characterization of an immobilized enzyme reactor based on glyceraldehyde-3-phosphate dehydrogenase for on-line enzymatic studies.
Journal of chromatography. A 2003;987(1-2):331-40.
2003: Moaddel Ruin; Wainer Irving W
Immobilized nicotinic receptor stationary phases: going with the flow in high-throughput screening and pharmacological studies.
Journal of pharmaceutical and biomedical analysis 2003;30(6):1715-24.
2002: Marshall John L; Rizvi Naiyer; Kauh John; Dahut William; Figuera Manuela; Kang Min H; Figg William D; Wainer Irving; Chaissang Christoff; Li Megan Zhaoyang; Hawkins Michael J
A phase I trial of depsipeptide (FR901228) in patients with advanced cancer.
Journal of experimental therapeutics & oncology 2002;2(6):325-32.
2002: Cassiano Neila M; Cass Quezia B; Degani Ana Luiza G; Wainer Irving W
Determination of the plasma levels of metyrapone and its enantiomeric metyrapol metabolites by direct plasma injection and multidimensional achiral-chiral chromatography.
Chirality 2002;14(9):731-5.
2002: Jozwiak Krzysztof; Haginaka Jun; Moaddel Ruin; Wainer Irving W
Displacement and nonlinear chromatographic techniques in the investigation of interaction of noncompetitive inhibitors with an immobilized alpha3beta4 nicotinic acetylcholine receptor liquid chromatographic stationary phase.
Analytical chemistry 2002;74(18):4618-24.
2002: Di Marco Marika Pasternyk; Edwards David J; Wainer Irving W; Ducharme Murray P
The effect of grapefruit juice and seville orange juice on the pharmacokinetics of dextromethorphan: the role of gut CYP3A and P-glycoprotein.
Life sciences 2002;71(10):1149-60.
2002: Baynham Michael T; Patel Sharvil; Moaddel Ruin; Wainer Irving W
Multidimensional on-line screening for ligands to the alpha3beta4 neuronal nicotinic acetylcholine receptor using an immobilized nicotinic receptor liquid chromatographic stationary phase.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2002;772(1):155-61.
2002: Yasuda Sally Usdin; Zannikos Peter; Young Andrea E; Fried Karen M; Wainer Irving W; Woosley Raymond L
The roles of CYP2D6 and stereoselectivity in the clinical pharmacokinetics of chlorpheniramine.
British journal of clinical pharmacology 2002;53(5):519-25.
2002: Williams Marion L; Wainer Irving W
Role of chiral chromatography in therapeutic drug monitoring and in clinical and forensic toxicology.
Therapeutic drug monitoring 2002;24(2):290-6.
2002: Markoglou Nektaria; Wainer Irving W
Biosynthesis in an on-line immobilized-enzyme reactor containing phenylethanolamine N-methyltransferase in single-enzyme and coupled-enzyme formats.
Journal of chromatography. A 2002;948(1-2):249-56.
2002: Moaddel Ruin; Lu Lili; Baynham Michael; Wainer Irving W
Immobilized receptor- and transporter-based liquid chromatographic phases for on-line pharmacological and biochemical studies: a mini-review.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2002;768(1):41-53.
2002: Shibukaw Akimasa; Yoshikawa Yuki; Kimura Tomoko; Kuroda Yukihiro; Nakagawa Terumichi; Wainer Irving W
Binding study of desethyloxybutynin using high-performance frontal analysis method.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2002;768(1):189-97.
2002: Shibukawa Akimasa; Ishizawa Nobuko; Kimura Tomoko; Sakamoto Yuki; Ogita Kanae; Matsuo Yuka; Kuroda Yukihiro; Matayatsu Chutima; Nakagawa Terumichi; Wainer Irving W
Plasma protein binding study of oxybutynin by high-performance frontal analysis.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2002;768(1):177-88.
2002: Williams Marion L; Wainer Irving W
Genotype/phenotype comparisons: a probe for the effect of disease progression on drug metabolism.
Current opinion in drug discovery & development 2002;5(1):144-9.
2002: Moaddel Ruin; Cloix Jean-François; Ertem Gözen; Wainer Irving W
Multiple receptor liquid chromatographic stationary phases: the co-immobilization of nicotinic receptors, gamma-amino-butyric acid receptors, and N-methyl D-aspartate receptors.
Pharmaceutical research 2002;19(1):104-7.
2002: Markoglou Nektaria; Wainer Irving W
On-line synthesis utilizing immobilized enzyme reactors based upon immobilized dopamine beta-hydroxylase.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2002;766(1):145-51.
2002: Fried Karen M; Young Andrea E; Usdin Yasuda Sally; Wainer Irving W
The enantioselective determination of chlorpheniramine and its major metabolites in human plasma using chiral chromatography on a beta-cyclodextrin chiral stationary phase and mass spectrometric detection.
Journal of pharmaceutical and biomedical analysis 2002;27(3-4):479-88.
2001: Lu L; Leonessa F; Baynham M T; Clarke R; Gimenez F; Pham Y T; Roux F; Wainer I W
The enantioselective binding of mefloquine enantiomers to P-glycoprotein determined using an immobilized P-glycoprotein liquid chromatographic stationary phase.
Pharmaceutical research 2001;18(9):1327-30.
2001: Cabal-Manzano R; Bhargava P; Torres-Duarte A; Marshall J; Bhargava P; Wainer I W
Proteolysis-inducing factor is expressed in tumours of patients with gastrointestinal cancers and correlates with weight loss.
British journal of cancer 2001;84(12):1599-601.
2001: Cloix J F; Wainer I W
Development of an immobilized brain glutamine synthetase liquid chromatographic stationary phase for on-line biochemical studies.
Journal of chromatography. A 2001;913(1-2):133-40.
2001: Bendriss E K; Markoglou N; Wainer I W
High-performance liquid chromatography assay for simultaneous determination of dextromethorphan and its main metabolites in urine and in microsomal preparations.
Journal of chromatography. B, Biomedical sciences and applications 2001;754(1):209-15.
2001: Markoglou N; Wainer I W
Synthesis and characterization of immobilized dopamine beta-hydroxylase in membrane-bound and solubilized formats.
Journal of biochemical and biophysical methods 2001;48(1):61-75.
2001: Davydova N N; Glisic J; Wainer I W
Determination of 8-chloroadenosine 3',5'-monophosphate in dog plasma by capillary electrophoresis.
Journal of pharmaceutical and biomedical analysis 2001;24(5-6):857-62.
2001: Massolini G; De Lorenzi E; Calleri E; Bertucci C; Monaco H L; Perduca M; Caccialanza G; Wainer I W
Properties of a stationary phase based on immobilised chicken liver basic fatty acid-binding protein.
Journal of chromatography. B, Biomedical sciences and applications 2001;751(1):117-30.
2001: Bansal R; Chen H X; Marshall J L; Tan J; Glazer R I; Wainer I W
Detection of a mixed-backbone oligonucleotide (GEM 231) in liver and tumor tissues by capillary electrophoresis.
Journal of chromatography. B, Biomedical sciences and applications 2001;750(1):129-35.
2001: Markoglou N; Wainer I W
Synthesis and characterization of an immobilized phenylethanolamine N-methyltransferase liquid chromatographic stationary phase.
Analytical biochemistry 2001;288(1):83-8.
2001: Lu L; Leonessa F; Clarke R; Wainer I W
Competitive and allosteric interactions in ligand binding to P-glycoprotein as observed on an immobilized P-glycoprotein liquid chromatographic stationary phase.
Molecular pharmacology 2001;59(1):62-8.
2000: Pham Y T; Régina A; Farinotti R; Couraud P; Wainer I W; Roux F; Gimenez F
Interactions of racemic mefloquine and its enantiomers with P-glycoprotein in an immortalised rat brain capillary endothelial cell line, GPNT.
Biochimica et biophysica acta 2000;1524(2-3):212-9.
2000: Woodland C; Ito S; Granvil C P; Wainer I W; Klein J; Koren G
Evidence of renal metabolism of ifosfamide to nephrotoxic metabolites.
Life sciences 2000;68(1):109-17.
2000: Auclair B; Wainer I W; Fried K; Koch P; Jerussi T P; Ducharme M P
A population analysis of nebulized (R)-albuterol in dogs using a novel mixed gut-lung absorption PK-PD model.
Pharmaceutical research 2000;17(10):1228-35.
2000: Bendriss E K; Markoglou N; Wainer I W
Liquid chromatographic method for the simultaneous determination of caffeine and fourteen caffeine metabolites in urine.
Journal of chromatography. B, Biomedical sciences and applications 2000;746(2):331-8.
2000: Davydova N N; Yasuda S U; Woosley R L; Wainer I W
Determination of clemastine in human plasma by gas chromatography with nitrogen-phosphorus detection.
Journal of chromatography. B, Biomedical sciences and applications 2000;744(1):177-81.
2000: Abernethy D R; Wainer I W; Anacleto A I
Verapamil metabolite exposure in older and younger men during steady-state oral verapamil administration.
Drug metabolism and disposition: the biological fate of chemicals 2000;28(7):760-5.
2000: Di Marco M P; Wainer I W; Granvil C L; Batist G; Ducharme M P
New insights into the pharmacokinetics and metabolism of (R,S)-ifosfamide in cancer patients using a population pharmacokinetic-metabolism model.
Pharmaceutical research 2000;17(6):645-52.
2000: O'Neil W M; Gilfix B M; Markoglou N; Di Girolamo A; Tsoukas C M; Wainer I W
Genotype and phenotype of cytochrome P450 2D6 in human immunodeficiency virus-positive patients and patients with acquired immunodeficiency syndrome.
European journal of clinical pharmacology 2000;56(3):231-40.
2000: Williams M L; Bhargava P; Cherrouk I; Marshall J L; Flockhart D A; Wainer I W
A discordance of the cytochrome P450 2C19 genotype and phenotype in patients with advanced cancer.
British journal of clinical pharmacology 2000;49(5):485-8.
2000: Zhang Y; Leonessa F; Clarke R; Wainer I W
Development of an immobilized P-glycoprotein stationary phase for on-line liquid chromatographic determination of drug-binding affinities.
Journal of chromatography. B, Biomedical sciences and applications 2000;739(1):33-7.
1999: Chassaing C; Gonin J; Wilcox C S; Wainer I W
Determination of reduced and oxidized homocysteine and related thiols in plasma by thiol-specific pre-column derivatization and capillary electrophoresis with laser-induced fluorescence detection.
Journal of chromatography. B, Biomedical sciences and applications 1999;735(2):219-27.
1999: O'Neil W M; Pezzullo J C; Di Girolamo A; Tsoukas C M; Wainer I W
Glucuronidation and sulphation of paracetamol in HIV-positive patients and patients with AIDS.
British journal of clinical pharmacology 1999;48(6):811-8.
1999: Williams M L; Wainer I W
Cyclophosphamide versus ifosfamide: to use ifosfamide or not to use, that is the three-dimensional question.
Current pharmaceutical design 1999;5(8):665-72.
1999: Davydova N N; Gotti R; Welch W J; Wainer I W
Determination of iothalamate in rat urine, plasma, and tubular fluid by capillary electrophoresis.
Journal of chromatography. B, Biomedical sciences and applications 1999;728(1):143-9.
1999: Granvil C P; Madan A; Sharkawi M; Parkinson A; Wainer I W
Role of CYP2B6 and CYP3A4 in the in vitro N-dechloroethylation of (R)- and (S)-ifosfamide in human liver microsomes.
Drug metabolism and disposition: the biological fate of chemicals 1999;27(4):533-41.
1999: Wainer I W; Zhang Y; Xiao Y; Kellar K J
Liquid chromatographic studies with immobilized neuronal nicotinic acetylcholine receptor stationary phases: effects of receptor subtypes, pH and ionic strength on drug-receptor interactions.
Journal of chromatography. B, Biomedical sciences and applications 1999;724(1):65-72.
1999: Williams M L; Wainer I W; Embree L; Barnett M; Granvil C L; Ducharme M P
Enantioselective induction of cyclophosphamide metabolism by phenytoin.
Chirality 1999;11(7):569-74.
1999: Williams M L; Wainer I W; Granvil C P; Gehrcke B; Bernstein M L; Ducharme M P
Pharmacokinetics of (R)- and (S)-cyclophosphamide and their dechloroethylated metabolites in cancer patients.
Chirality 1999;11(4):301-8.
1999: Sotolongo V; Johnson D V; Wahnon D; Wainer I W
Immobilized horse liver alcohol dehydrogenase as an on-line high-performance liquid chromatographic enzyme reactor for stereoselective synthesis.
Chirality 1999;11(1):39-45.
1998: Pasternyk M; Ducharme M P; Descorps V; Felix G; Wainer I W
On-line deconjugation of chloramphenicol-beta-D-glucuronide on an immobilized beta-glucuronidase column. Application to the direct analysis of urine samples.
Journal of chromatography. A 1998;828(1-2):135-40.
1998: Chassaing C; Marshall J L; Wainer I W
Determination of the antitumor agent depsipeptide in plasma by liquid chromatography on serial octadecyl stationary phases.
Journal of chromatography. B, Biomedical sciences and applications 1998;719(1-2):169-76.
1998: Zhang Y; Xiao Y; Kellar K J; Wainer I W
Immobilized nicotinic receptor stationary phase for on-line liquid chromatographic determination of drug-receptor affinities.
Analytical biochemistry 1998;264(1):22-5.
1998: Di Girolamo A; O'Neill W M; Wainer I W
A validated method for the determination of paracetamol and its glucuronide and sulphate metabolites in the urine of HIV+/AIDS patients using wavelength-switching UV detection.
Journal of pharmaceutical and biomedical analysis 1998;17(6-7):1191-7.
1998: Di Marco M P; Felix G; Descorps V; Ducharme M P; Wainer I W
On-line deconjugation of glucuronides using an immobilized enzyme reactor based upon beta-glucuronidase.
Journal of chromatography. B, Biomedical sciences and applications 1998;715(2):379-86.
1998: Diaz-Perez M J; Zannis-Hadjopoulos M; Price G B; Wainer I W
Receptor independent effects on DNA replication by steroids.
Journal of cellular biochemistry 1998;70(3):323-9.
1998: Azzaoui K; Diaz-Perez M J; Zannis-Hadjoupoulos M; Price G B; Wainer I W
Effect of steroids on DNA synthesis in an in vitro replication system: initial quantitative structure-activity relationship studies and construction of a non-estrogen receptor pharmacophore.
Journal of medicinal chemistry 1998;41(9):1392-8.
1998: Fried K M; Koch P; Wainer I W
Determination of the enantiomers of albuterol in human and canine plasma by enantioselective high-performance liquid chromatography on a teicoplanin-based chiral stationary phase.
Chirality 1998;10(5):484-91.
1997: Cummins C L; O'Neil W M; Soo E C; Lloyd D K; Wainer I W
Determination of p-aminosalicylic acid and its N-acetylated metabolite in human urine by capillary zone electrophoresis as a measure of in vivo N-acetyltransferase 1 activity.
Journal of chromatography. B, Biomedical sciences and applications 1997;697(1-2):283-8.
1997: O'Neil W M; Gilfix B M; DiGirolamo A; Tsoukas C M; Wainer I W
N-acetylation among HIV-positive patients and patients with AIDS: when is fast, fast and slow, slow?
Clinical pharmacology and therapeutics 1997;62(3):261-71.
1997: Markoglou N; Wainer I W
Determination of the anticancer agent CI-980 in plasma by achiral liquid chromatography on a Pirkle-type stationary phase.
Journal of chromatography. B, Biomedical sciences and applications 1997;693(2):493-7.
1997: Ducharme J; Fried K; Shenouda G; Leyland-Jones B; Wainer I W
Tamoxifen metabolic patterns within a glioma patient population treated with high-dose tamoxifen.
British journal of clinical pharmacology 1997;43(2):189-93.
1997: Fried K; Wainer I W
Column-switching techniques in the biomedical analysis of stereoisomeric drugs: why, how and when.
Journal of chromatography. B, Biomedical sciences and applications 1997;689(1):91-104.
1997: Ducharme M P; Bernstein M L; Granvil C P; Gehrcke B; Wainer I W
Phenytoin-induced alteration in the N-dechloroethylation of ifosfamide stereoisomers.
Cancer chemotherapy and pharmacology 1997;40(6):531-3.
1996: Diaz-Perez M J; Wainer I W; Zannis-Hadjopoulos M; Price G B
Application of an in vitro system in the study of chemotherapeutic drug effects on DNA replication.
Journal of cellular biochemistry 1996;61(3):444-51.
1996: Ducharme J; Abdullah S; Wainer I W
Dextromethorphan as an in vivo probe for the simultaneous determination of CYP2D6 and CYP3A activity.
Journal of chromatography. B, Biomedical applications 1996;678(1):113-28.
1996: Fernandez C; Egginger G; Wainer I W; Lloyd D K
Separation of testosterone metabolites in microsomal incubates using a new capillary electrophoresis assay.
Journal of chromatography. B, Biomedical applications 1996;677(2):363-8.
1996: Knoche B; Gehrcke B; König W A; Wainer I W
Determination of the enantiomeric composition of mexiletine and its four hydroxylated metabolites in urine by enantioselective capillary gas chromatography.
Chirality 1996;8(1):30-4.
1996: Granvil C P; Ducharme J; Leyland-Jones B; Trudeau M; Wainer I W
Stereoselective pharmacokinetics of ifosfamide and its 2- and 3-N-dechloroethylated metabolites in female cancer patients.
Cancer chemotherapy and pharmacology 1996;37(5):451-6.
1996: Wainer I W; Ducharme J; Granvil C P
The N-dechloroethylation of ifosfamide: using stereochemistry to obtain an accurate picture of a clinically relevant metabolic pathway.
Cancer chemotherapy and pharmacology 1996;37(4):332-6.
1995: Sandor V; Flarakos T; Batist G; Wainer I W; Lloyd D K
Quantitation of the diastereoisomers of L-buthionine-(R,S)-sulfoximine in human plasma: a validated assay by capillary electrophoresis.
Journal of chromatography. B, Biomedical applications 1995;673(1):123-31.
1995: Aubry A F; Markoglou N; Adams M H; Longstreth J; Wainer I W
The effect of co-administered drugs on oxaprozin binding to human serum albumin.
The Journal of pharmacy and pharmacology 1995;47(11):937-44.
1995: Wong P; Leyland-Jones B; Wainer I W
A competitive enzyme linked immunosorbent assay for the determination of N-acetyltransferase (NAT2) phenotypes.
Journal of pharmaceutical and biomedical analysis 1995;13(9):1079-86.
1995: Ducharme J; Fieger H; Ducharme M P; Khalil S K; Wainer I W
Enantioselective disposition of hydroxychloroquine after a single oral dose of the racemate to healthy subjects.
British journal of clinical pharmacology 1995;40(2):127-33.
1995: Chiarotto J A; Wainer I W
Determination of metyrapone and the enantiomers of its chiral metabolite metyrapol in human plasma and urine using coupled achiral-chiral liquid chromatography.
Journal of chromatography. B, Biomedical applications 1995;665(1):147-54.
1995: Hage D S; Noctor T A; Wainer I W
Characterization of the protein binding of chiral drugs by high-performance affinity chromatography. Interactions of R- and S-ibuprofen with human serum albumin.
Journal of chromatography. A 1995;693(1):23-32.
1994: Fried K M; Wainer I W
Direct determination of tamoxifen and its four major metabolites in plasma using coupled column high-performance liquid chromatography.
Journal of chromatography. B, Biomedical applications 1994;655(2):261-8.
1994: Wainer I W; Ducharme J; Granvil C P; Trudeau M; Leyland-Jones B
Ifosfamide stereoselective dichloroethylation and neurotoxicity.
Lancet 1994;343(8903):982-3.
1994: Wainer I W; Chen J C; Parenteau H; Abdullah S; Ducharme J; Fieger H; Iredale J
Distribution of the enantiomers of hydroxychloroquine and its metabolites in ocular tissues of the rabbit after oral administration of racemic-hydroxychloroquine.
Chirality 1994;6(4):347-54.
1994: Ducharme J; Wainer I W; Parenteau H I; Rodman J H
Stereoselective distribution of hydroxychloroquine in the rabbit following single and multiple oral doses of the racemate and the separate enantiomers.
Chirality 1994;6(4):337-46.
1993: Wainer I W; Granvil C P
Stereoselective separations of chiral anticancer drugs and their application to pharmacodynamic and pharmacokinetic studies.
Therapeutic drug monitoring 1993;15(6):570-5.
1993: Granville C P; Gehrcke B; König W A; Wainer I W
Determination of the enantiomers of ifosfamide and its 2- and 3-N-dechloroethylated metabolites in plasma and urine using enantioselective gas chromatography with mass spectrometric detection.
Journal of chromatography 1993;622(1):21-31.
1993: Fieger H; Wainer I W
Direct analysis of the enantiomers of mexiletine and its metabolites in plasma and urine using an HPLC-CSP.
Journal of pharmaceutical and biomedical analysis 1993;11(11-12):1173-9.
1993: Iredale J; Fieger H; Wainer I W
Determination of the stereoisomers of hydroxychloroquine and its major metabolites in plasma and urine following a single oral administration of racemic hydroxychloroquine.
Seminars in arthritis and rheumatism 1993;23(2 Suppl 1):74-81.
1993: Massolini G; Aubry A F; McGann A; Wainer I W
Determination of the magnitude and enantioselectivity of ligand binding to rat and rabbit serum albumins using immobilized-protein high performance liquid chromatography stationary phases.
Biochemical pharmacology 1993;46(7):1285-93.
1993: Kaliszan R; Kaliszan A; Wainer I W
Deactivated hydrocarbonaceous silica and immobilized artificial membrane stationary phases in high-performance liquid chromatographic determination of hydrophobicities of organic bases: relationship to log P and CLOGP.
Journal of pharmaceutical and biomedical analysis 1993;11(6):505-11.
1993: Kaliszan R; Kaliszan A; Wainer I W
Prediction of drug binding to melanin using a melanin-based high-performance liquid chromatographic stationary phase and chemometric analysis of the chromatographic data.
Journal of chromatography 1993;615(2):281-8.
1993: Wainer I W; Kaliszan R; Noctor T A
Biochromatography using immobilized biopolymers: a new approach to the determination of pharmacological properties.
The Journal of pharmacy and pharmacology 1993;45 Suppl 1():367-73.
1993: Wainer I W; Noctor T A
Molecular biochromatography: an approach to the liquid chromatographic determination of ligand-biopolymer interactions.
Advances in chromatography 1993;33():67-96.
1993: Wainer I W
Stereoisomers in clinical oncology: why it is important to know what the right and left hands are doing.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 1993;4 Suppl 2():7-13.
1993: Fieger H; Iredale J; Wainer I W
Enantioselective determination of hydroxychloroquine and its major metabolites in urine and the observation of a reversal in the (+)/(-)-hydroxychloroquine ratio.
Chirality 1993;5(2):65-70.
1992: Wainer I W
Three-dimensional view of pharmacology.
American journal of hospital pharmacy 1992;49(9 Suppl 1):S4-8.
1992: Kaliszan R; Noctor T A; Wainer I W
Stereochemical aspects of benzodiazepine binding to human serum albumin. II. Quantitative relationships between structure and enantioselective retention in high performance liquid affinity chromatography.
Molecular pharmacology 1992;42(3):512-7.
1992: Noctor T A; Pham C D; Kaliszan R; Wainer I W
Stereochemical aspects of benzodiazepine binding to human serum albumin. I. Enantioselective high performance liquid affinity chromatographic examination of chiral and achiral binding interactions between 1,4-benzodiazepines and human serum albumin.
Molecular pharmacology 1992;42(3):506-11.
1992: Lloyd D K; Fried K; Wainer I W
Determination of N-acetylator phenotype using caffeine as a probe compound: a comparison of high-performance liquid chromatography and capillary electrophoresis methods.
Journal of chromatography 1992;578(2):283-91.
1992: Noctor T A; Wainer I W; Hage D S
Allosteric and competitive displacement of drugs from human serum albumin by octanoic acid, as revealed by high-performance liquid affinity chromatography, on a human serum albumin-based stationary phase.
Journal of chromatography 1992;577(2):305-15.
1992: Noctor T A; Wainer I W
The in situ acetylation of an immobilized human serum albumin chiral stationary phase for high-performance liquid chromatography in the examination of drug-protein binding phenomena.
Pharmaceutical research 1992;9(4):480-4.
1992: Chui W K; Wainer I W
Enzyme-based high-performance liquid chromatography supports as probes of enzyme activity and inhibition: the immobilization of trypsin and alpha-chymotrypsin on an immobilized artificial membrane high-performance liquid chromatography support.
Analytical biochemistry 1992;201(2):237-45.
1992: Shibukawa A; Wainer I W
Simultaneous direct determination of the enantiomers of verapamil and norverapamil in plasma using a derivatized amylose high-performance liquid chromatographic chiral stationary phase.
Journal of chromatography 1992;574(1):85-92.
1992: Iredale J; Wainer I W
Determination of hydroxychloroquine and its major metabolites in plasma using sequential achiral-chiral high-performance liquid chromatography.
Journal of chromatography 1992;573(2):253-8.

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