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Harald Wajant

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Co-Publications
Name
34
Scheurich, Peter
24
Pfizenmaier, Klaus
18
Siegmund, Daniela
13
Grell, Matthias
9
Schwenzer, Ralph
8
Effenberger, Franz
8
Peters, Nathalie
7
Henkler, Frank
7
Förster, Siegfried
7
Gerspach, Jeannette
5
Haas, E
5
Lauble, Hanspeter
5
Mühlenbeck, F
5
Schubert, G
5
Siemienski, K

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Publications

TOP 3
Wicovsky A; Salzmann S; Roos C; Ehrenschwender M; Rosenthal T; Siegmund D; Henkler F; Gohlke F; Kneitz C; Wajant H
TNF-like weak inducer of apoptosis inhibits proinflammatory TNF receptor-1 signaling.
Wyzgol Agnes; Müller Nicole; Fick Andrea; Munkel Sabine; Grigoleit Goetz Ulrich; Pfizenmaier Klaus; Wajant Harald
Trimer stabilization, oligomerization, and antibody-mediated cell surface immobilization improve the activity of soluble trimers of CD27L, CD40L, 41BBL, and glucocorticoid-induced TNF receptor ligand.
Gerspach Jeannette; Pfizenmaier Klaus; Wajant Harald
Improving TNF as a cancer therapeutic: tailor-made TNF fusion proteins with conserved antitumor activity and reduced systemic side effects.

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All Publications

2009: Wicovsky A; Salzmann S; Roos C; Ehrenschwender M; Rosenthal T; Siegmund D; Henkler F; Gohlke F; Kneitz C; Wajant H
TNF-like weak inducer of apoptosis inhibits proinflammatory TNF receptor-1 signaling.
Cell death and differentiation 2009;16(11):1445-59.
2009: Wyzgol Agnes; Müller Nicole; Fick Andrea; Munkel Sabine; Grigoleit Goetz Ulrich; Pfizenmaier Klaus; Wajant Harald
Trimer stabilization, oligomerization, and antibody-mediated cell surface immobilization improve the activity of soluble trimers of CD27L, CD40L, 41BBL, and glucocorticoid-induced TNF receptor ligand.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(3):1851-61.
2009: Gerspach Jeannette; Pfizenmaier Klaus; Wajant Harald
Improving TNF as a cancer therapeutic: tailor-made TNF fusion proteins with conserved antitumor activity and reduced systemic side effects.
BioFactors (Oxford, England) 2009;35(4):364-72.
2009: Schmidt Enno; Gutberlet Judith; Siegmund Daniela; Berg Daniela; Wajant Harald; Waschke Jens
Apoptosis is not required for acantholysis in pemphigus vulgaris.
American journal of physiology. Cell physiology 2009;296(1):C162-72.
2009: Ehrenschwender Martin; Wajant Harald
The Role of FasL and Fas in Health and Disease.
Advances in experimental medicine and biology 2009;647():64-93.
2008: Müller Nicole; Wyzgol Agnes; Münkel Sabine; Pfizenmaier Klaus; Wajant Harald
Activity of soluble OX40 ligand is enhanced by oligomerization and cell surface immobilization.
The FEBS journal 2008;275(9):2296-304.
2008: von Langermann Jan; Guterl Jan-Karl; Pohl Martina; Wajant Harald; Kragl Udo
Hydroxynitrile lyase catalyzed cyanohydrin synthesis at high pH-values.
Bioprocess and biosystems engineering 2008;31(3):155-61.
2008: Egberts Jan-Hendrik; Cloosters Vera; Noack Andreas; Schniewind Bodo; Thon Lutz; Klose Stefanie; Kettler Bastian; von Forstner Corinna; Kneitz Christian; Tepel Jürgen; Adam Dieter; Wajant Harald; Kalthoff Holger; Trauzold Anna
Anti-tumor necrosis factor therapy inhibits pancreatic tumor growth and metastasis.
Cancer research 2008;68(5):1443-50.
2008: Bremer Edwin; ten Cate Bram; Samplonius Douwe F; Mueller Nicole; Wajant Harald; Stel Alja J; Chamuleau Martine; van de Loosdrecht Arjan A; Stieglmaier Julia; Fey Georg H; Helfrich Wijnand
Superior activity of fusion protein scFvRit:sFasL over cotreatment with rituximab and Fas agonists.
Cancer research 2008;68(2):597-604.
2007: Berg D; Lehne M; Müller N; Siegmund D; Münkel S; Sebald W; Pfizenmaier K; Wajant H
Enforced covalent trimerization increases the activity of the TNF ligand family members TRAIL and CD95L.
Cell death and differentiation 2007;14(12):2021-34.
2007: Siegmund Daniela; Klose Stefanie; Zhou Donghui; Baumann Bernd; Röder Christian; Kalthoff Holger; Wajant Harald; Trauzold Anna
Role of caspases in CD95L- and TRAIL-induced non-apoptotic signalling in pancreatic tumour cells.
Cellular signalling 2007;19(6):1172-84.
2007: Peter Marcus E; Budd Ralph C; Desbarats Julie; Hedrick Stephen M; Hueber Anne-Odile; Newell M Karen; Owen Laurie B; Pope Richard M; Tschopp Juerg; Wajant Harald; Wallach David; Wiltrout Robert H; Zörnig Martin; Lynch David H
The CD95 receptor: apoptosis revisited.
Cell 2007;129(3):447-50.
2007: Watermann I; Gerspach J; Lehne M; Seufert J; Schneider B; Pfizenmaier K; Wajant H
Activation of CD95L fusion protein prodrugs by tumor-associated proteases.
Cell death and differentiation 2007;14(4):765-74.
2007: Wicovsky Andreas; Müller Nicole; Daryab Neda; Marienfeld Ralf; Kneitz Christian; Kavuri Shyam; Leverkus Martin; Baumann Bernd; Wajant Harald
Sustained JNK activation in response to tumor necrosis factor is mediated by caspases in a cell type-specific manner.
The Journal of biological chemistry 2007;282(4):2174-83.
2006: Gerspach Jeannette; Németh Julia; Münkel Sabine; Wajant Harald; Pfizenmaier Klaus
Target-selective activation of a TNF prodrug by urokinase-type plasminogen activator (uPA) mediated proteolytic processing at the cell surface.
Cancer immunology, immunotherapy : CII 2006;55(12):1590-600.
2006: Trauzold A; Siegmund D; Schniewind B; Sipos B; Egberts J; Zorenkov D; Emme D; Röder C; Kalthoff H; Wajant H
TRAIL promotes metastasis of human pancreatic ductal adenocarcinoma.
Oncogene 2006;25(56):7434-9.
2006: Assohou-Luty Constance; Gerspach Jeanette; Siegmund Daniela; Müller Nicole; Huard Bertrand; Tiegs Gisa; Pfizenmaier Klaus; Wajant Harald
A CD40-CD95L fusion protein interferes with CD40L-induced prosurvival signaling and allows membrane CD40L-restricted activation of CD95.
Journal of molecular medicine (Berlin, Germany) 2006;84(9):785-97.
2006: Begue Bernadette; Wajant Harald; Bambou Jean-Christophe; Dubuquoy Laurent; Siegmund Daniela; Beaulieu Jean-François; Canioni Danielle; Berrebi Dominique; Brousse Nicole; Desreumaux Pierre; Schmitz Jacques; Lentze Michael J; Goulet Oliver; Cerf-Bensussan Nadine; Ruemmele Frank M
Implication of TNF-related apoptosis-inducing ligand in inflammatory intestinal epithelial lesions.
Gastroenterology 2006;130(7):1962-74.
2006: Gerspach J; Müller D; Münkel S; Selchow O; Nemeth J; Noack M; Petrul H; Menrad A; Wajant H; Pfizenmaier K
Restoration of membrane TNF-like activity by cell surface targeting and matrix metalloproteinase-mediated processing of a TNF prodrug.
Cell death and differentiation 2006;13(2):273-84.
2006: Wajant Harald
CD95L/FasL and TRAIL in tumour surveillance and cancer therapy.
Cancer treatment and research 2006;130():141-65.
2005: Wicovsky Andreas; Siegmund Daniela; Wajant Harald
Interferons induce proteolytic degradation of TRAILR4.
Biochemical and biophysical research communications 2005;337(1):184-90.
2005: Siegmund Daniela; Wicovsky Andreas; Schmitz Ingo; Schulze-Osthoff Klaus; Kreuz Sebastian; Leverkus Martin; Dittrich-Breiholz Oliver; Kracht Michael; Wajant Harald
Death receptor-induced signaling pathways are differentially regulated by gamma interferon upstream of caspase 8 processing.
Molecular and cellular biology 2005;25(15):6363-79.
2005: Trauzold Anna; Röder Christian; Sipos Bence; Karsten Kristin; Arlt Alexander; Jiang Ping; Martin-Subero Jose Ignacio; Siegmund Daniela; Müerköster Susanne; Pagerols-Raluy Laia; Siebert Reiner; Wajant Harald; Kalthoff Holger
CD95 and TRAF2 promote invasiveness of pancreatic cancer cells.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005;19(6):620-2.
2005: Henkler Frank; Behrle Eva; Dennehy Kevin M; Wicovsky Andreas; Peters Nathalie; Warnke Clemens; Pfizenmaier Klaus; Wajant Harald
The extracellular domains of FasL and Fas are sufficient for the formation of supramolecular FasL-Fas clusters of high stability.
The Journal of cell biology 2005;168(7):1087-98.
2005: Wajant Harald; Gerspach Jeannette; Pfizenmaier Klaus
Tumor therapeutics by design: targeting and activation of death receptors.
Cytokine & growth factor reviews 2005;16(1):55-76.
2004: Chaneva Svetla; Schneider Günter; Siegmund Daniela; Wajant Harald; Mages Jörg; Häcker Georg
Enhanced basal AP-1 activity and de-regulation of numerous genes in T cells transgenic for a dominant interfering mutant of FADD/MORT1.
European journal of immunology 2004;34(11):3006-15.
2004: Kreuz Sebastian; Siegmund Daniela; Rumpf Jost-Julian; Samel Dierk; Leverkus Martin; Janssen Ottmar; Häcker Georg; Dittrich-Breiholz Oliver; Kracht Michael; Scheurich Peter; Wajant Harald
NFkappaB activation by Fas is mediated through FADD, caspase-8, and RIP and is inhibited by FLIP.
The Journal of cell biology 2004;166(3):369-80.
2004: Fotin-Mleczek Mariola; Henkler Frank; Hausser Angelika; Glauner Heike; Samel Dierk; Graness Angela; Scheurich Peter; Mauri Davide; Wajant Harald
Tumor necrosis factor receptor-associated factor (TRAF) 1 regulates CD40-induced TRAF2-mediated NF-kappaB activation.
The Journal of biological chemistry 2004;279(1):677-85.
2004: Wajant Harald
TRAIL and NFkappaB signaling--a complex relationship.
Vitamins and hormones 2004;67():101-32.
2004: Wajant H; Scheurich P
Analogies between Drosophila and mammalian TRAF pathways.
Progress in molecular and subcellular biology 2004;34():47-72.
2003: Samel Dierk; Muller Dafne; Gerspach Jeannette; Assohou-Luty Constance; Sass Gabriele; Tiegs Gisa; Pfizenmaier Klaus; Wajant Harald
Generation of a FasL-based proapoptotic fusion protein devoid of systemic toxicity due to cell-surface antigen-restricted Activation.
The Journal of biological chemistry 2003;278(34):32077-82.
2003: Henkler Frank; Baumann Bernd; Fotin-Mleczek Mariola; Weingärtner Monika; Schwenzer Ralph; Peters Nathalie; Graness Angela; Wirth Thomas; Scheurich Peter; Schmid Johannes A; Wajant Harald
Caspase-mediated cleavage converts the tumor necrosis factor (TNF) receptor-associated factor (TRAF)-1 from a selective modulator of TNF receptor signaling to a general inhibitor of NF-kappaB activation.
The Journal of biological chemistry 2003;278(31):29216-30.
2003: Wajant Harald
Targeting the FLICE Inhibitory Protein (FLIP) in cancer therapy.
Molecular interventions 2003;3(3):124-7.
2003: Bühler Holger; Effenberger Franz; Förster Siegfried; Roos Jürgen; Wajant Harald
Substrate specificity of mutants of the hydroxynitrile lyase from Manihot esculenta.
Chembiochem : a European journal of chemical biology 2003;4(2-3):211-6.
2003: Wajant Harald; Pfizenmaier Klaus; Scheurich Peter
Non-apoptotic Fas signaling.
Cytokine & growth factor reviews 2003;14(1):53-66.
2003: Wajant H; Pfizenmaier K; Scheurich P
Tumor necrosis factor signaling.
Cell death and differentiation 2003;10(1):45-65.
2003: Wajant Harald
Death receptors.
Essays in biochemistry 2003;39():53-71.
2002: Siegmund Daniela; Hadwiger Philipp; Pfizenmaier Klaus; Vornlocher Hans-Peter; Wajant Harald
Selective inhibition of FLICE-like inhibitory protein expression with small interfering RNA oligonucleotides is sufficient to sensitize tumor cells for TRAIL-induced apoptosis.
Molecular medicine (Cambridge, Mass.) 2002;8(11):725-32.
2002: Baumann Bernd; Bohnenstengel Frank; Siegmund Daniela; Wajant Harald; Weber Christoph; Herr Ingrid; Debatin Klaus-Michael; Proksch Peter; Wirth Thomas
Rocaglamide derivatives are potent inhibitors of NF-kappa B activation in T-cells.
The Journal of biological chemistry 2002;277(47):44791-800.
2002: Lauble Hanspeter; Miehlich Burkhard; Förster Siegfried; Wajant Harald; Effenberger Franz
Crystal structure of hydroxynitrile lyase from Sorghum bicolor in complex with the inhibitor benzoic acid: a novel cyanogenic enzyme.
Biochemistry 2002;41(40):12043-50.
2002: Glauner Heike; Siegmund Daniela; Motejadded Hassan; Scheurich Peter; Henkler Frank; Janssen Ottmar; Wajant Harald
Intracellular localization and transcriptional regulation of tumor necrosis factor (TNF) receptor-associated factor 4 (TRAF4).
European journal of biochemistry / FEBS 2002;269(19):4819-29.
2002: Wajant H; Pfizenmaier K; Scheurich P
TNF-related apoptosis inducing ligand (TRAIL) and its receptors in tumor surveillance and cancer therapy.
Apoptosis : an international journal on programmed cell death 2002;7(5):449-59.
2002: Weingärtner Monika; Siegmund Daniela; Schlecht Ulrich; Fotin-Mleczek Mariola; Scheurich Peter; Wajant Harald
Endogenous membrane tumor necrosis factor (TNF) is a potent amplifier of TNF receptor 1-mediated apoptosis.
The Journal of biological chemistry 2002;277(38):34853-9.
2002: Fotin-Mleczek Mariola; Henkler Frank; Samel Dierk; Reichwein Monica; Hausser Angelika; Parmryd Ingela; Scheurich Peter; Schmid Johannes A; Wajant Harald
Apoptotic crosstalk of TNF receptors: TNF-R2-induces depletion of TRAF2 and IAP proteins and accelerates TNF-R1-dependent activation of caspase-8.
Journal of cell science 2002;115(Pt 13):2757-70.
2002: Wajant Harald
The Fas signaling pathway: more than a paradigm.
Science (New York, N.Y.) 2002;296(5573):1635-6.
2002: Wajant Harald; Effenberger Franz
Characterization and synthetic applications of recombinant AtNIT1 from Arabidopsis thaliana.
European journal of biochemistry / FEBS 2002;269(2):680-7.
2002: Lauble Hanspeter; Miehlich Burkhard; Förster Siegfried; Kobler Christoph; Wajant Harald; Effenberger Franz
Structure determinants of substrate specificity of hydroxynitrile lyase from Manihot esculenta.
Protein science : a publication of the Protein Society 2002;11(1):65-71.
2001: Siegmund D; Hausser A; Peters N; Scheurich P; Wajant H
Tumor necrosis factor (TNF) and phorbol ester induce TNF-related apoptosis-inducing ligand (TRAIL) under critical involvement of NF-kappa B essential modulator (NEMO)/IKKgamma.
The Journal of biological chemistry 2001;276(47):43708-12.
2001: Siegmund D; Mauri D; Peters N; Juo P; Thome M; Reichwein M; Blenis J; Scheurich P; Tschopp J; Wajant H
Fas-associated death domain protein (FADD) and caspase-8 mediate up-regulation of c-Fos by Fas ligand and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) via a FLICE inhibitory protein (FLIP)-regulated pathway.
The Journal of biological chemistry 2001;276(35):32585-90.
2001: Wajant H; Moosmayer D; Wüest T; Bartke T; Gerlach E; Schönherr U; Peters N; Scheurich P; Pfizenmaier K
Differential activation of TRAIL-R1 and -2 by soluble and membrane TRAIL allows selective surface antigen-directed activation of TRAIL-R2 by a soluble TRAIL derivative.
Oncogene 2001;20(30):4101-6.
2001: Wajant H; Henkler F; Scheurich P
The TNF-receptor-associated factor family: scaffold molecules for cytokine receptors, kinases and their regulators.
Cellular signalling 2001;13(6):389-400.
2001: Kreuz S; Siegmund D; Scheurich P; Wajant H
NF-kappaB inducers upregulate cFLIP, a cycloheximide-sensitive inhibitor of death receptor signaling.
Molecular and cellular biology 2001;21(12):3964-73.
2001: Lauble H; Miehlich B; Förster S; Wajant H; Effenberger F
Mechanistic aspects of cyanogenesis from active-site mutant Ser80Ala of hydroxynitrile lyase from Manihot esculenta in complex with acetone cyanohydrin.
Protein science : a publication of the Protein Society 2001;10(5):1015-22.
2001: Wajant H; Pfizenmaier K
[From tumor necrosis factor to TRAIL-AMAIZe: second generation antitumorally effective cytokines]
Onkologie 2001;24 Suppl 1():6-10.
2001: Bartke T; Siegmund D; Peters N; Reichwein M; Henkler F; Scheurich P; Wajant H
p53 upregulates cFLIP, inhibits transcription of NF-kappaB-regulated genes and induces caspase-8-independent cell death in DLD-1 cells.
Oncogene 2001;20(5):571-80.
2001: Lauble H; Förster S; Miehlich B; Wajant H; Effenberger F
Structure of hydroxynitrile lyase from Manihot esculenta in complex with substrates acetone and chloroacetone: implications for the mechanism of cyanogenesis.
Acta crystallographica. Section D, Biological crystallography 2001;57(Pt 2):194-200.
2001: Wajant H; Scheurich P
Tumor necrosis factor receptor-associated factor (TRAF) 2 and its role in TNF signaling.
The international journal of biochemistry & cell biology 2001;33(1):19-32.
2000: Effenberger F; Förster S; Wajant H
Hydroxynitrile lyases in stereoselective catalysis.
Current opinion in biotechnology 2000;11(6):532-9.
2000: Mühlenbeck F; Schneider P; Bodmer J L; Schwenzer R; Hauser A; Schubert G; Scheurich P; Moosmayer D; Tschopp J; Wajant H
The tumor necrosis factor-related apoptosis-inducing ligand receptors TRAIL-R1 and TRAIL-R2 have distinct cross-linking requirements for initiation of apoptosis and are non-redundant in JNK activation.
The Journal of biological chemistry 2000;275(41):32208-13.
2000: Schwenzer R; Zimmermann G; Fotin M; Wajant H; Grell M
No RISC, no fun: assembly of receptor-induced signalling complexes in the tumor necrosis factor system.
European cytokine network 2000;11(3):519-20.
2000: Engels I H; Stepczynska A; Stroh C; Lauber K; Berg C; Schwenzer R; Wajant H; Jänicke R U; Porter A G; Belka C; Gregor M; Schulze-Osthoff K; Wesselborg S
Caspase-8/FLICE functions as an executioner caspase in anticancer drug-induced apoptosis.
Oncogene 2000;19(40):4563-73.
2000: Wajant H; Haas E; Schwenzer R; Muhlenbeck F; Kreuz S; Schubert G; Grell M; Smith C; Scheurich P
Inhibition of death receptor-mediated gene induction by a cycloheximide-sensitive factor occurs at the level of or upstream of Fas-associated death domain protein (FADD).
The Journal of biological chemistry 2000;275(32):24357-66.
2000: Irmler M; Steiner V; Ruegg C; Wajant H; Tschopp J
Caspase-induced inactivation of the anti-apoptotic TRAF1 during Fas ligand-mediated apoptosis.
FEBS letters 2000;468(2-3):129-33.
1999: Schwenzer R; Siemienski K; Liptay S; Schubert G; Peters N; Scheurich P; Schmid R M; Wajant H
The human tumor necrosis factor (TNF) receptor-associated factor 1 gene (TRAF1) is up-regulated by cytokines of the TNF ligand family and modulates TNF-induced activation of NF-kappaB and c-Jun N-terminal kinase.
The Journal of biological chemistry 1999;274(27):19368-74.
1999: Schneider P; Schwenzer R; Haas E; Mühlenbeck F; Schubert G; Scheurich P; Tschopp J; Wajant H
TWEAK can induce cell death via endogenous TNF and TNF receptor 1.
European journal of immunology 1999;29(6):1785-92.
1999: Haas E; Grell M; Wajant H; Scheurich P
Continuous autotropic signaling by membrane-expressed tumor necrosis factor.
The Journal of biological chemistry 1999;274(25):18107-12.
1999: Grell M; Zimmermann G; Gottfried E; Chen C M; Grünwald U; Huang D C; Wu Lee Y H; Dürkop H; Engelmann H; Scheurich P; Wajant H; Strasser A
Induction of cell death by tumour necrosis factor (TNF) receptor 2, CD40 and CD30: a role for TNF-R1 activation by endogenous membrane-anchored TNF.
The EMBO journal 1999;18(11):3034-43.
1999: Lauble H; Decanniere K; Wajant H; Förster S; Effenberger F
Crystallization and preliminary x-ray diffraction analysis of hydroxynitrile lyase from cassava (Manihot esculenta).
Acta crystallographica. Section D, Biological crystallography 1999;55(Pt 4):904-6.
1999: Wajant H; Grell M; Scheurich P
TNF receptor associated factors in cytokine signaling.
Cytokine & growth factor reviews 1999;10(1):15-26.
1998: Wajant H; Mühlenbeck F; Scheurich P
Identification of a TRAF (TNF receptor-associated factor) gene in Caenorhabditis elegans.
Journal of molecular evolution 1998;47(6):656-62.
1998: Mühlenbeck F; Haas E; Schwenzer R; Schubert G; Grell M; Smith C; Scheurich P; Wajant H
TRAIL/Apo2L activates c-Jun NH2-terminal kinase (JNK) via caspase-dependent and caspase-independent pathways.
The Journal of biological chemistry 1998;273(49):33091-8.
1998: Johannes F J; Horn J; Link G; Haas E; Siemienski K; Wajant H; Pfizenmaier K
Protein kinase Cmu downregulation of tumor-necrosis-factor-induced apoptosis correlates with enhanced expression of nuclear-factor-kappaB-dependent protective genes.
European journal of biochemistry / FEBS 1998;257(1):47-54.
1998: Wajant H; Pfeffer K; Pfizenmaier K; Scheurich P
Tumor necrosis factors in 1998.
Cytokine & growth factor reviews 1998;9(3-4):297-302.
1998: Weiss T; Grell M; Siemienski K; Mühlenbeck F; Dürkop H; Pfizenmaier K; Scheurich P; Wajant H
TNFR80-dependent enhancement of TNFR60-induced cell death is mediated by TNFR-associated factor 2 and is specific for TNFR60.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(6):3136-42.
1998: Grell M; Becke F M; Wajant H; Männel D N; Scheurich P
TNF receptor type 2 mediates thymocyte proliferation independently of TNF receptor type 1.
European journal of immunology 1998;28(1):257-63.
1998: Grell M; Wajant H; Zimmermann G; Scheurich P
The type 1 receptor (CD120a) is the high-affinity receptor for soluble tumor necrosis factor.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(2):570-5.
1998: Wajant H; Johannes F J; Haas E; Siemienski K; Schwenzer R; Schubert G; Weiss T; Grell M; Scheurich P
Dominant-negative FADD inhibits TNFR60-, Fas/Apo1- and TRAIL-R/Apo2-mediated cell death but not gene induction.
Current biology : CB 1998;8(2):113-6.
1997: Siemienski K; Peters N; Scheurich P; Wajant H
Organization of the human tumour necrosis factor receptor-associated factor 1 (TRAF1) gene and mapping to chromosome 9q33-34.
Gene 1997;195(1):35-9.
1997: Weiss T; Grell M; Hessabi B; Bourteele S; Müller G; Scheurich P; Wajant H
Enhancement of TNF receptor p60-mediated cytotoxicity by TNF receptor p80: requirement of the TNF receptor-associated factor-2 binding site.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(5):2398-404.
1997: Trummler K; Wajant H
Molecular cloning of acetone cyanohydrin lyase from flax (Linum usitatissimum). Definition of a novel class of hydroxynitrile lyases.
The Journal of biological chemistry 1997;272(8):4770-4.
1996: Pfizenmaier K; Wajant H; Grell M
Tumor necrosis factors in 1996.
Cytokine & growth factor reviews 1996;7(3):271-7.
1996: Wajant H; Förster S; Sprauer A; Effenberger F; Pfizenmaier K
Enantioselective synthesis of aliphatic (S)-cyanohydrins in organic solvents using hydroxynitrile lyase from Manihot esculenta.
Annals of the New York Academy of Sciences 1996;799():771-6.
1996: Wajant H; Effenberger F
Hydroxynitrile lyases of higher plants.
Biological chemistry 1996;377(10):611-7.
1996: Wajant H; Pfizenmaier K
Identification of potential active-site residues in the hydroxynitrile lyase from Manihot esculenta by site-directed mutagenesis.
The Journal of biological chemistry 1996;271(42):25830-4.
1996: Lauble H; Knödler S; Schindelin H; Förster S; Wajant H; Effenberger F
Crystallographic studies and preliminary X-ray investigation of (S)-p-hydroxy-mandelonitrile lyase from Sorghum bicolor (L.).
Acta crystallographica. Section D, Biological crystallography 1996;52(Pt 4):887-9.
1996: Moosmayer D; Wajant H; Gerlach E; Schmidt M; Brocks B; Pfizenmaier K
Characterization of different soluble TNF receptor (TNFR80) derivatives: positive influence of the intracellular domain on receptor/ligand interaction and TNF neutralization capacity.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 1996;16(6):471-7.
1996: Hornung E; Wajant H; Jeske H; Mundry K W
Cloning of a cDNA encoding a new ribosome-inactivating protein from Beta vulgaris vulgaris (mangold).
Gene 1996;170(2):233-6.
1995: Grell M; Douni E; Wajant H; Löhden M; Clauss M; Maxeiner B; Georgopoulos S; Lesslauer W; Kollias G; Pfizenmaier K; Scheurich P
The transmembrane form of tumor necrosis factor is the prime activating ligand of the 80 kDa tumor necrosis factor receptor.
Cell 1995;83(5):793-802.
1994: Wajant H; Mundry K W; Pfizenmaier K
Molecular cloning of hydroxynitrile lyase from Sorghum bicolor (L.). Homologies to serine carboxypeptidases.
Plant molecular biology 1994;26(2):735-46.

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