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Moacir Wajner

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Estela Natacha Brandt Busanello; Anelise Miotti Tonin; Carmen R Vargas; Carolina Maso Viegas; Alexandre Umpierrez Amaral; Angela Zanatta; Moacir Wajner
Disruption of mitochondrial homeostasis by phytanic acid in cerebellum of young rats.
Estela Natacha Brandt Busanello; Diogo Onofre Gomes de Souza; Stephen Goodman; David M Koeller; Pablo Pandolfo; Letícia Pettenuzzo; Paulo Henrique Botton; Michael Woontner; Moacir Wajner
Neurodevelopmental and cognitive behavior of glutaryl-CoA dehydrogenase deficient knockout mice.
Estela Natacha Brandt Busanello; Guilhian Leipnitz; César Augusto João Ribeiro; Anelise Miotti Tonin; Carmen R Vargas; Carolina Maso Viegas; Ângela Zanatta; Moacir Wajner
Marked inhibition of Na+, K(+)- ATPase activity and the respiratory chain by phytanic acid in cerebellum from young rats: possible underlying mechanisms of cerebellar ataxia in Refsum disease.

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2013: Estela Natacha Brandt Busanello; Anelise Miotti Tonin; Carmen R Vargas; Carolina Maso Viegas; Alexandre Umpierrez Amaral; Angela Zanatta; Moacir Wajner
Disruption of mitochondrial homeostasis by phytanic acid in cerebellum of young rats.
Cerebellum (London, England) 2013;12(3):362-9.
2013: Estela Natacha Brandt Busanello; Diogo Onofre Gomes de Souza; Stephen Goodman; David M Koeller; Pablo Pandolfo; Letícia Pettenuzzo; Paulo Henrique Botton; Michael Woontner; Moacir Wajner
Neurodevelopmental and cognitive behavior of glutaryl-CoA dehydrogenase deficient knockout mice.
Life sciences 2013;92(2):137-42.
2013: Estela Natacha Brandt Busanello; Guilhian Leipnitz; César Augusto João Ribeiro; Anelise Miotti Tonin; Carmen R Vargas; Carolina Maso Viegas; Ângela Zanatta; Moacir Wajner
Marked inhibition of Na+, K(+)- ATPase activity and the respiratory chain by phytanic acid in cerebellum from young rats: possible underlying mechanisms of cerebellar ataxia in Refsum disease.
Journal of bioenergetics and biomembranes 2013;45(1-2):137-44.
2013: Caroline Paula Mescka; Carolina Souza; Camila Simioni Vanzin; Giovana Brondani Biancini; Carlos Severo Dutra-Filho; Gilian Guerreiro; Vanusa Manfredini; Moacir Wajner; Carlos Alberto Yasin Wayhs; Carmen R Vargas
Protein and lipid damage in maple syrup urine disease patients: l-carnitine effect.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 2013;31(1):21-4.
2013: Anelise M Tonin; Alexandre U Amaral; Estela N B Busanello; Roger F Castilho; Mateus Grings; Moacir Wajner
Long-chain 3-hydroxy fatty acids accumulating in long-chain 3-hydroxyacyl-CoA dehydrogenase and mitochondrial trifunctional protein deficiencies uncouple oxidative phosphorylation in heart mitochondria.
Journal of bioenergetics and biomembranes 2013;45(1-2):47-57.
2013: André Quincozes-Santos; Diogo Onofre Souza; Moacir Wajner; Larissa Daniele Bobermin; Carlos-Alberto Gonçalves; Alexandra Latini; Carmem Gottfried
Resveratrol Protects C6 Astrocyte Cell Line against Hydrogen Peroxide-Induced Oxidative Stress through Heme Oxygenase 1.
PloS one 2013;8(5):e64372.
2013: Bianca Seminotti; Michael Woontner; Alexandre Umpierrez Amaral; Luis Barbeito; Mateus Struecker da Rosa; Diogo Onofre Gomes de Souza; Carolina Gonçalves Fernandes; Stephen I Goodman; David M Koeller; Guilhian Leipnitz; Silvia Olivera-Bravo; César Augusto J Ribeiro; Moacir Wajner
Disruption of brain redox homeostasis in glutaryl-CoA dehydrogenase deficient mice treated with high dietary lysine supplementation.
Molecular genetics and metabolism 2013;108(1):30-9.
2013: Ângela Zanatta; Carlos Severo Dutra-Filho; Mateus Grings; Lisiane Aurélio Knebel; Guilhian Leipnitz; Vannessa Araújo Lobato; Alana Pimentel Moura; César Augusto João Ribeiro; Anelise Miotti Tonin; Moacir Wajner
Neurochemical evidence that the metabolites accumulating in 3-methylcrotonyl-CoA carboxylase deficiency induce oxidative damage in cerebral cortex of young rats.
Cellular and molecular neurobiology 2013;33(1):137-46.
2012: Carolina M Viegas; Angela Zanatta; Estela Natacha Brandt Busanello; Carolina Gonçalves Fernandes; Guilhian Leipnitz; Alana Pimentel Moura; Bianca Seminotti; Anelise Miotti Tonin; Moacir Wajner
Impairment of brain redox homeostasis caused by the major metabolites accumulating in hyperornithinemia-hyperammonemia-homocitrullinuria syndrome in vivo.
Metabolic brain disease 2012;27(4):521-30.
2012: Carolina M Viegas; Angela Zanatta; Estela Natacha Brandt Busanello; Mateus Grings; Lisiane Aurélio Knebel; Guilhian Leipnitz; Vannessa Araujo Lobato; Alana Pimentel Moura; Leticia F Pettenuzzo; Luciana Ritter; Anelise Miotti Tonin; Carmen R Vargas; Moacir Wajner
Chronic postnatal ornithine administration to rats provokes learning deficit in the open field task.
Metabolic brain disease 2012;27(4):479-86.
2012: Alexandre Umpierrez Amaral; Maurício Reis Bogo; Estela Natacha Brandt Busanello; Cristiane Cecatto; Diogo Onofre Gomes de Souza; Carolina Gonçalves Fernandes; Stephen Goodman; Luiza Wilges Kist; David M Koeller; Bianca Seminotti; Michael Woontner; Ângela Zanatta; Moacir Wajner
Reduction of Na+, K+-ATPase activity and expression in cerebral cortex of glutaryl-CoA dehydrogenase deficient mice: a possible mechanism for brain injury in glutaric aciduria type I.
Molecular genetics and metabolism 2012;107(3):375-82.
2012: Lisiane Aurélio Knebel; Leonardo de Moura Alvorcem; Mateus Grings; Anelise Miotti Tonin; Moacir Wajner; Ângela Zanatta; Guilhian Leipnitz
2-Methylbutyrylglycine induces lipid oxidative damage and decreases the antioxidant defenses in rat brain.
Brain research 2012;1478():74-82.
2012: Luciane Rosa Feksa; Larissa Machado Lacerda; Rafael Linden; Mateus Luchese; Evandro Oliveira; Denise Bertin Rojas; Patricia Fernanda Schuck; Thereza Trombini; Moacir Wajner; Clovis Milton Duval Wannmacher; Rodrigo Binkowski Andrade; Daiane Bolzan Berlese; Saiuri Bisi; Tatiana Emanuelli
Pyruvate kinase activity and δ-aminolevulinic acid dehydratase activity as biomarkers of toxicity in workers exposed to lead.
Archives of environmental contamination and toxicology 2012;63(3):453-60.
2012: Graziela S Ribas; Daiane Rodrigues; Camila S Vanzin; Giovana B Biancini; Janice Carneiro Coelho; Caroline Paula Mescka; Giovanna Negretto; Ricardo Pires; Moacir Wajner; Carlos A Y Wayhs; Carmen R Vargas
Oxidative stress in Niemann-Pick type C patients: a protective role of N-butyl-deoxynojirimycin therapy.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 2012;30(6):439-44.
2012: Alexandre Umpierrez Amaral; Luisa Macedo Braga; Estela Natacha Brandt Busanello; Cristiane Cecatto; Diogo Onofre Gomes de Souza; Carolina Gonçalves Fernandes; Stephen Goodman; David M Koeller; César Augusto João Ribeiro; Bianca Seminotti; Michael Woontner; Ângela Zanatta; Moacir Wajner
Marked reduction of Na(+), K(+)-ATPase and creatine kinase activities induced by acute lysine administration in glutaryl-CoA dehydrogenase deficient mice.
Molecular genetics and metabolism 2012;107(1-2):81-6.
2012: Anelise M Tonin; Ângela Zanatta; Mateus Grings; Lisiane A Knebel; Guilhian Leipnitz; Alana P Moura; César A J Ribeiro; Moacir Wajner
Disruption of redox homeostasis in cerebral cortex of developing rats by acylcarnitines accumulating in medium-chain acyl-CoA dehydrogenase deficiency.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 2012;30(5):383-90.
2012: Mateus Grings; Lisiane Aurélio Knebel; Carlos Severo Dutra Filho; Alana Pimentel Moura; Anelise Miotti Tonin; Moacir Wajner; Angela Zanatta; Guilhian Leipnitz
Phytanic acid disturbs mitochondrial homeostasis in heart of young rats: a possible pathomechanism of cardiomyopathy in Refsum disease.
Molecular and cellular biochemistry 2012;366(1-2):335-43.
2012: Bianca Seminotti; Michael Woontner; Alexandre Umpierrez Amaral; Luisa Macedo Braga; Mateus Struecker da Rosa; Diogo Onofre Gomes de Souza; Carolina Gonçalves Fernandes; Stephen Goodman; David M Koeller; Guilhian Leipnitz; Moacir Wajner
Induction of oxidative stress in brain of glutaryl-CoA dehydrogenase deficient mice by acute lysine administration.
Molecular genetics and metabolism 2012;106(1):31-8.
2012: Estela Natacha Brandt Busanello; Paula Eichler; Mateus Grings; Alana Pimentel Moura; Anelise Miotti Tonin; Carmen R Vargas; Alexandre Umpierrez Amaral; Moacir Wajner
Experimental evidence that pristanic acid disrupts mitochondrial homeostasis in brain of young rats.
Journal of neuroscience research 2012;90(3):597-605.
2012: Alana Pimentel Moura; César Augusto João Ribeiro; Anelise Miotti Tonin; Estela Natacha Brandt Busanello; Ângela Zanatta; Moacir Wajner
3-Methylcrotonylglycine disrupts mitochondrial energy homeostasis and inhibits synaptic Na(+),K (+)-ATPase activity in brain of young rats.
Cellular and molecular neurobiology 2012;32(2):297-307.
2012: Paula Pierozan; Karina Pires Reis; Moacir Wajner; Fernanda Zamboni; Ariane Zamoner; Ângela Krombauer Soska; Bárbara Ortiz de Lima; Regina Pessoa Pureur
Signaling mechanisms downstream of quinolinic acid targeting the cytoskeleton of rat striatal neurons and astrocytes.
Experimental neurology 2012;233(1):391-9.
2012: Graziela S Ribas; Angela Sitta; Giovana B Biancini; Caroline Mescka; Moacir Wajner; Carlos Y Wayhs; Carmen R Vargas
Oxidative stress parameters in urine from patients with disorders of propionate metabolism: a beneficial effect of L:-carnitine supplementation.
Cellular and molecular neurobiology 2012;32(1):77-82.
2011: Camila Simioni Vanzin; Moacir Wajner; Carlos Alberto Yasin Wayhs; Angela Terezinha de Souza Wyse; Giovana Brondani Biancini; Solange Cristina Garcia; Izabela Netto Pereira; Francieli Rockenbach; Ida V D Schwartz; Angela Sitta; Carmen R Vargas
Experimental evidence of oxidative stress in plasma of homocystinuric patients: a possible role for homocysteine.
Molecular genetics and metabolism 2011;104(1-2):112-7.
2011: Graziela S Ribas; Angela Sitta; Moacir Wajner; Carmen R Vargas
Oxidative stress in phenylketonuria: what is the evidence?
Cellular and molecular neurobiology 2011;31(5):653-62.
2011: Carolina Gonçalves Fernandes; Clarissa Günther Borges; Bianca Seminotti; Alexandre Umpierrez Amaral; Lisiane Aurélio Knebel; Paula Eichler; Anderson Büker de Oliveira; Guilhian Leipnitz; Moacir Wajner
Experimental evidence that methylmalonic acid provokes oxidative damage and compromises antioxidant defenses in nerve terminal and striatum of young rats.
Cellular and molecular neurobiology 2011;31(5):775-85.
2011: Estela Natacha Brandt Busanello; Carolina Maso Viegas; Anelise Miotti Tonin; Mateus Grings; Alana Pimentel Moura; Anderson Büker de Oliveira; Paula Eichler; Moacir Wajner
Neurochemical evidence that pristanic acid impairs energy production and inhibits synaptic Na(+), K(+)-ATPase activity in brain of young rats.
Neurochemical research 2011;36(6):1101-7.
2011: Angela Sitta; C S Vanzin; G B Biancini; V Manfredini; A B de Oliveira; C A Y Wayhs; G O S Ribas; L Giugliani; Ida V D Schwartz; D Bohrer; S C Garcia; Moacir Wajner; Carmen R Vargas
Evidence that L-carnitine and selenium supplementation reduces oxidative stress in phenylketonuric patients.
Cellular and molecular neurobiology 2011;31(3):429-36.
2011: Guilhian Leipnitz; Alexandre Umpierrez Amaral; Carolina Gonçalves Fernandes; Bianca Seminotti; Angela Zanatta; Lisiane Aurélio Knebel; Carmen R Vargas; Moacir Wajner
Pristanic acid promotes oxidative stress in brain cortex of young rats: a possible pathophysiological mechanism for brain damage in peroxisomal disorders.
Brain research 2011;1382():259-65.
2011: Daniela R Melo; Alicia J Kowaltowski; Moacir Wajner; Roger F Castilho
Mitochondrial energy metabolism in neurodegeneration associated with methylmalonic acidemia.
Journal of bioenergetics and biomembranes 2011;43(1):39-46.
2011: Moacir Wajner; Stephen I Goodman
Disruption of mitochondrial homeostasis in organic acidurias: insights from human and animal studies.
Journal of bioenergetics and biomembranes 2011;43(1):31-8.
2011: César A J Ribeiro; Fernanda Hermes Hickmann; Moacir Wajner
Neurochemical evidence that 3-methylglutaric acid inhibits synaptic Na+,K+-ATPase activity probably through oxidative damage in brain cortex of young rats.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 2011;29(1):1-7.
2011: Bianca Seminotti; Carolina Gonçalves Fernandes; Guilhian Leipnitz; Alexandre Umpierrez Amaral; Angela Zanatta; Moacir Wajner
Neurochemical evidence that lysine inhibits synaptic Na+,K+-ATPase activity and provokes oxidative damage in striatum of young rats in vivo.
Neurochemical research 2011;36(2):205-14.
2011: Carolina M Viegas; Estela Natacha Brandt Busanello; Anelise Miotti Tonin; Alana Pimentel de Moura; Mateus Grings; Luciana Ritter; Patrícia F Schuck; Gustavo da C Ferreira; Angela Sitta; Carmen R Vargas; Moacir Wajner
Dual mechanism of brain damage induced in vivo by the major metabolites accumulating in hyperornithinemia-hyperammonemia-homocitrullinuria syndrome.
Brain research 2011;1369():235-44.
2010: Belén Pérez; Celia Angaroni; Rocio Sánchez-Alcudia; Begoña Merinero; Celia Pérez-Cerdá; N Specola; Pilar Rodríguez-Pombo; Moacir Wajner; Raquel Dodelson de Kremer; Verónica Cornejo; Lourdes R Desviat; Magdalena Ugarte
The molecular landscape of propionic acidemia and methylmalonic aciduria in Latin America.
Journal of inherited metabolic disease 2010;33(Suppl 2):S307-14.
2010: Graziela S Ribas; Vanusa Manfredini; Maria Gilda de Marco; Rosana B Vieira; Carlos Y Wayhs; Camila S Vanzin; Giovana B Biancini; Moacir Wajner; Carmen R Vargas
Prevention by L-carnitine of DNA damage induced by propionic and L-methylmalonic acids in human peripheral leukocytes in vitro.
Mutation research 2010;702(1):123-8.
2010: Estela Natacha Brandt Busanello; Carolina M Viegas; Alana Pimentel Moura; Anelise Miotti Tonin; Mateus Grings; Carmen R Vargas; Moacir Wajner
In vitro evidence that phytanic acid compromises Na(+),K(+)-ATPase activity and the electron flow through the respiratory chain in brain cortex from young rats.
Brain research 2010;1352():231-8.
2010: Guilhian Leipnitz; Bianca Seminotti; Alexandre U Amaral; Carolina G Fernandes; Carlos Severo Dutra-Filho; Moacir Wajner
Evidence that 2-methylacetoacetate induces oxidative stress in rat brain.
Metabolic brain disease 2010;25(3):261-7.
2010: Guilhian Leipnitz; Alexandre U Amaral; Angela Zanatta; Bianca Seminotti; Carolina G Fernandes; Lisiane A Knebel; Carmen R Vargas; Moacir Wajner
Neurochemical evidence that phytanic acid induces oxidative damage and reduces the antioxidant defenses in cerebellum and cerebral cortex of rats.
Life sciences 2010;87(9-10):275-80.
2010: Patrícia F Schuck; Gustavo da C Ferreira; Erich Birelli Tahara; Fábio Klamt; Alicia Juliana Kowaltowski; Moacir Wajner
cis-4-decenoic acid provokes mitochondrial bioenergetic dysfunction in rat brain.
Life sciences 2010;87(5-6):139-46.
2010: Vanusa Manfredini; Giovana Brondani Biancini; Camila Simioni Vanzin; Anna Maria Ribeiro Dal Vesco; Franciele Cipriani; Lidiana Biasi; Roberta Treméa; Marion Deon; Maria do Carmo Ruaro Peralba; Moacir Wajner; Carmen R Vargas
Simvastatin treatment prevents oxidative damage to DNA in whole blood leukocytes of dyslipidemic type 2 diabetic patients.
Cell biochemistry and function 2010;28(5):360-6.
2010: Estela Natacha Brandt Busanello; Alana Pimentel Moura; Carolina M Viegas; Angela Zanatta; Gustavo da Costa Ferreira; Patrícia F Schuck; Moacir Wajner
Neurochemical evidence that glycine induces bioenergetical dysfunction.
Neurochemistry international 2010;56(8):948-54.
2010: Anelise M Tonin; Mateus Grings; Estela N B Busanello; Alana P Moura; Gustavo C Ferreira; Carolina M Viegas; Carolina G Fernandes; Patrícia F Schuck; Moacir Wajner
Long-chain 3-hydroxy fatty acids accumulating in LCHAD and MTP deficiencies induce oxidative stress in rat brain.
Neurochemistry international 2010;56(8):930-6.
2010: Paula Pierozan; Ariane Zamoner; Angela Krombauer Soska; Roberta Bristot Silvestrin; Samanta Oliveira Loureiro; Luana Heimfarth; Tadeu Mello e Souza; Moacir Wajner; Regina Pessoa Pureur
Acute intrastriatal administration of quinolinic acid provokes hyperphosphorylation of cytoskeletal intermediate filament proteins in astrocytes and neurons of rats.
Experimental neurology 2010;224(1):188-96.
2010: Andréa G K Ferreira; Daniela D Lima; Débora Delwing; Vanize Mackedanz; Bárbara Tagliari; Janaína Kolling; Patrícia F Schuck; Moacir Wajner; Angela T S Wyse
Proline impairs energy metabolism in cerebral cortex of young rats.
Metabolic brain disease 2010;25(2):161-8.
2010: Carolina D Pederzolli; Caroline Paula Mescka; Alessandra Selinger Magnusson; Kátia Bueno Deckmann; Evelise de Souza Streck; Angela M Sgaravatti; Mirian B Sgarbi; Angela T S Wyse; Clóvis M D Wannmacher; Moacir Wajner; Carlos Severo Dutra-Filho
N-acetylaspartic acid impairs enzymatic antioxidant defenses and enhances hydrogen peroxide concentration in rat brain.
Metabolic brain disease 2010;25(2):251-9.
2010: André Quincozes-Santos; Rafael B Rosa; Guilhian Leipnitz; Daniela Fraga de Souza; Bianca Seminotti; Moacir Wajner; Carlos-Alberto Gonçalves
Induction of S100B secretion in C6 astroglial cells by the major metabolites accumulating in glutaric acidemia type I.
Metabolic brain disease 2010;25(2):191-8.
2010: Carolina D Pederzolli; Caroline Paula Mescka; Bernardo Remuzzi Zandoná; Daniella de Moura Coelho; Angela M Sgaravatti; Mirian B Sgarbi; Angela Terezinha de Souza Wyse; Clóvis Milton Duval Wannmacher; Moacir Wajner; Carmen R Vargas; Carlos Severo Dutra-Filho
Acute administration of 5-oxoproline induces oxidative damage to lipids and proteins and impairs antioxidant defenses in cerebral cortex and cerebellum of young rats.
Metabolic brain disease 2010;25(2):145-54.
2010: Guilhian Leipnitz; Lucila de Bortoli da Silva; Carolina Gonçalves Fernandes; Bianca Seminotti; Alexandre Umpierrez Amaral; Carlos Severo Dutra-Filho; Moacir Wajner
d-Serine administration provokes lipid oxidation and decreases the antioxidant defenses in rat striatum.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 2010;28(4):297-301.
2010: Anelise M Tonin; Gustavo C Ferreira; Mateus Grings; Carolina M Viegas; Estela N Busanello; Alexandre U Amaral; Angela Zanatta; Patrícia F Schuck; Moacir Wajner
Disturbance of mitochondrial energy homeostasis caused by the metabolites accumulating in LCHAD and MTP deficiencies in rat brain.
Life sciences 2010;86(21-22):825-31.
2010: Tarsila Barros Moraes; Fernanda Zanin; Andrea da Rosa; Amanda de Oliveira; Juliana Coelho; Felipe Petrillo; Moacir Wajner; Carlos Severo Dutra-Filho
Lipoic acid prevents oxidative stress in vitro and in vivo by an acute hyperphenylalaninemia chemically-induced in rat brain.
Journal of the neurological sciences 2010;292(1-2):89-95.
2010: Alexandre Umpierrez Amaral; Guilhian Leipnitz; Carolina Gonçalves Fernandes; Bianca Seminotti; Patrícia F Schuck; Moacir Wajner
Alpha-ketoisocaproic acid and leucine provoke mitochondrial bioenergetic dysfunction in rat brain.
Brain research 2010;1324():75-84.
2010: Graziela S Ribas; Vanusa Manfredini; Jurema F de Mari; Carlos Y Wayhs; Camila S Vanzin; Giovana B Biancini; Angela Sitta; Marion Deon; Moacir Wajner; Carmen R Vargas
Reduction of lipid and protein damage in patients with disorders of propionate metabolism under treatment: a possible protective role of L-carnitine supplementation.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 2010;28(2):127-32.
2010: Carolina G Fernandes; Guilhian Leipnitz; Bianca Seminotti; Alexandre U Amaral; Angela Zanatta; Carmen R Vargas; Carlos S Dutra Filho; Moacir Wajner
Experimental evidence that phenylalanine provokes oxidative stress in hippocampus and cerebral cortex of developing rats.
Cellular and molecular neurobiology 2010;30(2):317-26.
2010: Patrícia F Schuck; Estela Natacha Brandt Busanello; Alana Pimentel Moura; Anelise Miotti Tonin; Mateus Grings; Luciana Ritter; Carmen R Vargas; Gustavo da Costa Ferreira; Moacir Wajner
Promotion of lipid and protein oxidative damage in rat brain by ethylmalonic acid.
Neurochemical research 2010;35(2):298-305.
2009: Angela Zanatta; Patrícia F Schuck; Carolina M Viegas; Lisiane Aurélio Knebel; Estela Natacha Brandt Busanello; Alana Pimentel Moura; Moacir Wajner
In vitro evidence that D-serine disturbs the citric acid cycle through inhibition of citrate synthase activity in rat cerebral cortex.
Brain research 2009;1298():186-93.
2009: Patrícia F Schuck; Gustavo da C Ferreira; Anelise Miotti Tonin; Carolina M Viegas; Estela Natacha Brandt Busanello; Alana Pimentel Moura; Angela Zanatta; Fábio Klamt; Moacir Wajner
Evidence that the major metabolites accumulating in medium-chain acyl-CoA dehydrogenase deficiency disturb mitochondrial energy homeostasis in rat brain.
Brain research 2009;1296():117-26.
2009: Alexandre Umpierrez Amaral; Guilhian Leipnitz; Carolina Gonçalves Fernandes; Bianca Seminotti; Angela Zanatta; Carolina M Viegas; Carlos Severo Dutra-Filho; Moacir Wajner
Evidence that the major metabolites accumulating in hyperornithinemia-hyperammonemia-homocitrullinuria syndrome induce oxidative stress in brain of young rats.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 2009;27(7):635-41.
2009: Carolina M Viegas; Angela Zanatta; Lisiane Aurélio Knebel; Patrícia F Schuck; Anelise Miotti Tonin; Gustavo da C Ferreira; Alexandre Umpierrez Amaral; Carlos Severo Dutra-Filho; Clóvis M D Wannmacher; Moacir Wajner
Experimental evidence that ornithine and homocitrulline disrupt energy metabolism in brain of young rats.
Brain research 2009;1291():102-12.
2009: Angela M Sgaravatti; Alessandra S Magnusson; Amanda S de Oliveira; Andréa P Rosa; Caroline Paula Mescka; Fernanda R Zanin; Carolina D Pederzolli; Angela T S Wyse; Clóvis M D Wannmacher; Moacir Wajner; Carlos Severo Dutra-Filho
Tyrosine administration decreases glutathione and stimulates lipid and protein oxidation in rat cerebral cortex.
Metabolic brain disease 2009;24(3):415-25.
2009: Angela Sitta; Vanusa Manfredini; Lidiana Biasi; Roberta Treméa; Ida V D Schwartz; Moacir Wajner; Carmen R Vargas
Evidence that DNA damage is associated to phenylalanine blood levels in leukocytes from phenylketonuric patients.
Mutation research 2009;679(1-2):13-6.
2009: Patrícia F Schuck; Gustavo C Ferreira; Alana P Moura; Estela N B Busanello; Anelise M Tonin; Carlos Severo Dutra-Filho; Moacir Wajner
Medium-chain fatty acids accumulating in MCAD deficiency elicit lipid and protein oxidative damage and decrease non-enzymatic antioxidant defenses in rat brain.
Neurochemistry international 2009;54(8):519-25.
2009: Marjan E Steenweg; Gajja S Salomons; Zuhal Yapici; Graziella Uziel; Emmanuel Scalais; Dimitrios I Zafeiriou; Maria L Ruiz-Falco; Vlatka Mejaski-Bosnjak; Persephone Augoustides-Savvopoulou; Moacir Wajner; John Walter; Nanda M Verhoeven-Duif; Eduard A Struys; Cornelis Jakobs; Marjo S van der Knaap
L-2-Hydroxyglutaric aciduria: pattern of MR imaging abnormalities in 56 patients.
Radiology 2009;251(3):856-65.
2009: Guilhian Leipnitz; Bianca Seminotti; Carolina G Fernandes; Alexandre U Amaral; Ana Paula Beskow; Lucila de B da Silva; Angela Zanatta; César A J Ribeiro; Carmen R Vargas; Moacir Wajner
Striatum is more vulnerable to oxidative damage induced by the metabolites accumulating in 3-hydroxy-3-methylglutaryl-CoA lyase deficiency as compared to liver.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 2009;27(4):351-6.
2009: Anelise Miotti Tonin; Gustavo C Ferreira; Patrícia F Schuck; Carolina M Viegas; Angela Zanatta; Guilhian Leipnitz; Bianca Seminotti; Clóvis Milton Duvall Wannmacher; Moacir Wajner
Inhibition of creatine kinase activity by lysine in rat cerebral cortex.
Metabolic brain disease 2009;24(2):349-60.
2009: Angela M Sgaravatti; Alessandra S Magnusson; Amanda S Oliveira; Caroline P Mescka; Fernanda Zanin; Mirian B Sgarbi; Carolina D Pederzolli; Angela T S Wyse; Clóvis M D Wannmacher; Moacir Wajner; Carlos Severo Dutra-Filho
Effects of 1,4-butanediol administration on oxidative stress in rat brain: study of the neurotoxicity of gamma-hydroxybutyric acid in vivo.
Metabolic brain disease 2009;24(2):271-82.
2009: Carolina D Pederzolli; Francieli Juliana Rockenbach; Fernanda Rech Zanin; Nicoli Taiana Henn; Eline Coan Romagna; Angela M Sgaravatti; Angela T S Wyse; Clóvis M D Wannmacher; Moacir Wajner; Angela de Mattos Dutra; Carlos Severo Dutra-Filho
Intracerebroventricular administration of N-acetylaspartic acid impairs antioxidant defenses and promotes protein oxidation in cerebral cortex of rats.
Metabolic brain disease 2009;24(2):283-98.
2009: Eliseu Felippe dos Santos; Estela Natacha Brandt Busanello; Anelise Miglioranza; Angela Zanatta; Alethea Gatto Barchak; Carmen R Vargas; Jonas Saute; Charles Rosa; Maria Júlia Carrion; Daiane Camargo; André Dalbem; Jaderson Costa DaCosta; Sandro René Pinto de Sousa Miguel; Carlos Roberto de Mello Rieder; Moacir Wajner
Evidence that folic acid deficiency is a major determinant of hyperhomocysteinemia in Parkinson's disease.
Metabolic brain disease 2009;24(2):257-69.
2009: Angela Sitta; Alethéa G Barschak; Marion Deon; Amanda T Barden; Giovana B Biancini; Paula R Vargas; Carolina F de Souza; Carlos Alexandre Netto; Moacir Wajner; Carmen R Vargas
Effect of short- and long-term exposition to high phenylalanine blood levels on oxidative damage in phenylketonuric patients.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 2009;27(3):243-7.
2009: Alethéa G Barschak; Angela Sitta; Marion Deon; Estela N B Busanello; Daniella M Coelho; Franciele Cipriani; Carlos Severo Dutra-Filho; Roberto Giugliani; Moacir Wajner; Carmen R Vargas
Amino acids levels and lipid peroxidation in maple syrup urine disease patients.
Clinical biochemistry 2009;42(6):462-6.
2009: César A J Ribeiro; Guilhian Leipnitz; Alexandre Umpierrez Amaral; Giorgia de Bortoli; Bianca Seminotti; Moacir Wajner
Creatine administration prevents Na+,K+-ATPase inhibition induced by intracerebroventricular administration of isovaleric acid in cerebral cortex of young rats.
Brain research 2009;1262():81-8.
2009: Guilhian Leipnitz; Alexandre F Solano; Bianca Seminotti; Alexandre U Amaral; Carolina G Fernandes; Ana Paula Beskow; Carlos Severo Dutra-Filho; Moacir Wajner
Glycine provokes lipid oxidative damage and reduces the antioxidant defenses in brain cortex of young rats.
Cellular and molecular neurobiology 2009;29(2):253-61.
2009: Angela Sitta; Alethéa G Barschak; Marion Deon; Jurema F de Mari; Amanda T Barden; Camila S Vanzin; Giovana B Biancini; Ida V D Schwartz; Moacir Wajner; Carmen R Vargas
L-carnitine blood levels and oxidative stress in treated phenylketonuric patients.
Cellular and molecular neurobiology 2009;29(2):211-8.
2009: Lucila de Bortoli da Silva; Guilhian Leipnitz; Bianca Seminotti; Carolina G Fernandes; Ana Paula Beskow; Alexandre U Amaral; Moacir Wajner
D-serine induces lipid and protein oxidative damage and decreases glutathione levels in brain cortex of rats.
Brain research 2009;1256():34-42.
2009: Patrícia F Schuck; Gustavo da C Ferreira; Carolina M Viegas; Anelise Miotti Tonin; Estela Natacha Brandt Busanello; Leticia F Pettenuzzo; Carlos Alexandre Netto; Moacir Wajner
Chronic early postnatal administration of ethylmalonic acid to rats causes behavioral deficit.
Behavioural brain research 2009;197(2):364-70.
2009: Moacir Wajner; Daniella de Moura Coelho; Rafaela Ingrassia; Anderson Büker de Oliveira; Estela Natacha Brandt Busanello; Kimiyo Raymond; Ricardo Flores Pires; Carolina Fischinger Moura de Souza; Roberto Giugliani; Carmen Regla Vargas
Selective screening for organic acidemias by urine organic acid GC-MS analysis in Brazil: fifteen-year experience.
Clinica chimica acta; international journal of clinical chemistry 2009;400(1-2):77-81.
2008: Silvia Olivera; Anabel Fernandez; Alexandra Latini; Juan Carlos Rosillo; Gabriela Casanova; Moacir Wajner; Patricia Cassina; Luis Barbeito
Astrocytic proliferation and mitochondrial dysfunction induced by accumulated glutaric acidemia I (GAI) metabolites: possible implications for GAI pathogenesis.
Neurobiology of disease 2008;32(3):528-34.
2008: Ana Paula Beskow; Carolina Gonçalves Fernandes; Guilhian Leipnitz; Lucila de Bortoli da Silva; Bianca Seminotti; Alexandre U Amaral; Angela T S Wyse; Clóvis M D Wannmacher; Carmen R Vargas; Carlos Severo Dutra-Filho; Moacir Wajner
Influence of ketone bodies on oxidative stress parameters in brain of developing rats in vitro.
Metabolic brain disease 2008;23(4):411-25.
2008: Bianca Seminotti; Guilhian Leipnitz; Alexandre U Amaral; Carolina G Fernandes; Lucila de Bortoli da Silva; Anelise Miotti Tonin; Carmen R Vargas; Moacir Wajner
Lysine induces lipid and protein damage and decreases reduced glutathione concentrations in brain of young rats.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 2008;26(7):693-8.
2008: Angela M Sgaravatti; Bethânia A Vargas; Bernardo R Zandoná; Kátia B Deckmann; Francieli J Rockenbach; Tarsila B Moraes; José M Monserrat; Mirian B Sgarbi; Carolina D Pederzolli; Angela T S Wyse; Clóvis M D Wannmacher; Moacir Wajner; Carlos Severo Dutra-Filho
Tyrosine promotes oxidative stress in cerebral cortex of young rats.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 2008;26(6):551-9.
2008: Alexandra I Zugno; Francieli M Stefanello; Emilene B S Scherer; Cristiane B Mattos; Carolina D Pederzolli; Vanessa Andrade; Clóvis M D Wannmacher; Moacir Wajner; Carlos Severo Dutra-Filho; Angela T S Wyse
Guanidinoacetate decreases antioxidant defenses and total protein sulfhydryl content in striatum of rats.
Neurochemical research 2008;33(9):1804-10.
2008: Alexandre F Solano; Guilhian Leipnitz; Giorgia M De Bortoli; Bianca Seminotti; Alexandre U Amaral; Carolina G Fernandes; Alexandra S Latini; Carlos Severo Dutra-Filho; Moacir Wajner
Induction of oxidative stress by the metabolites accumulating in isovaleric acidemia in brain cortex of young rats.
Free radical research 2008;42(8):707-15.
2008: Luciane Rosa Feksa; Alexandra Latini; Virginia Cielo Rech; Patrícia Bartels Feksa; Gustavo Duarte Waltereith Koch; Maria Fernanda Arevalo Amaral; Guilhian Leipnitz; Carlos Severo Dutra-Filho; Moacir Wajner; Clóvis M D Wannmacher
Tryptophan administration induces oxidative stress in brain cortex of rats.
Metabolic brain disease 2008;23(2):221-33.
2008: Carolina M Viegas; Gustavo da Costa Ferreira; Patrícia F Schuck; Anelise Miotti Tonin; Angela Zanatta; Angela Terezinha de Souza Wyse; Carlos Severo Dutra-Filho; Clóvis M D Wannmacher; Moacir Wajner
Evidence that 3-hydroxyisobutyric acid inhibits key enzymes of energy metabolism in cerebral cortex of young rats.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 2008;26(3-4):293-9.
2008: Adriana Kessler; Micheli Biasibetti; Denizar Alberto da Silva Melo; Moacir Wajner; Carlos Severo Dutra-Filho; Angela Terezinha de Souza Wyse; Clóvis M D Wannmacher
Antioxidant effect of cysteamine in brain cortex of young rats.
Neurochemical research 2008;33(5):737-44.
2008: Marion Deon; Angela Sitta; Alethéa G Barschak; Daniella M Coelho; Thatiana Terroso; Graziela O Schmitt; Hector Y C Wanderley; Laura B Jardim; Roberto Giugliani; Moacir Wajner; Carmen R Vargas
Oxidative stress is induced in female carriers of X-linked adrenoleukodystrophy.
Journal of the neurological sciences 2008;266(1-2):79-83.
2008: Guilhian Leipnitz; Bianca Seminotti; Alexandre U Amaral; Giorgia de Bortoli; Alexandre Solano; Patrícia F Schuck; Angela T S Wyse; Clóvis M D Wannmacher; Alexandra Latini; Moacir Wajner
Induction of oxidative stress by the metabolites accumulating in 3-methylglutaconic aciduria in cerebral cortex of young rats.
Life sciences 2008;82(11-12):652-62.
2008: Gustavo da Costa Ferreira; Patrícia F Schuck; Carolina M Viegas; Anelise Tonin; César A J Ribeiro; Leticia F Pettenuzzo; Lenir Orlandi Pereira; Carlos Alexandre Netto; Moacir Wajner
Chronic early postnatal glutaric acid administration causes cognitive deficits in the water maze.
Behavioural brain research 2008;187(2):411-6.
2008: Alethéa G Barschak; Christiane Marchesan; Angela Sitta; Marion Deon; Roberto Giugliani; Moacir Wajner; Carmen R Vargas
Maple syrup urine disease in treated patients: biochemical and oxidative stress profiles.
Clinical biochemistry 2008;41(4-5):317-24.
2008: Adriana Kessler; Micheli Biasibetti; Luciane Rosa Feksa; Virginia Cielo Rech; Denizar Alberto da Silva Melo; Moacir Wajner; Carlos Severo Dutra-Filho; Angela Terezinha de Souza Wyse; Clóvis M D Wannmacher
Effects of cysteamine on oxidative status in cerebral cortex of rats.
Metabolic brain disease 2008;23(1):81-93.
2008: Alethéa G Barschak; Angela Sitta; Marion Deon; Amanda T Barden; Carlos Severo Dutra-Filho; Moacir Wajner; Carmen R Vargas
Oxidative stress in plasma from maple syrup urine disease patients during treatment.
Metabolic brain disease 2008;23(1):71-80.
2008: Marion Deon; Mariana Pires Garcia; Angela Sitta; Alethéa G Barschak; Daniella M Coelho; Graziela O Schimit; Maiara Pigatto; Laura B Jardim; Moacir Wajner; Roberto Giugliani; Carmen R Vargas
Hexacosanoic and docosanoic acids plasma levels in patients with cerebral childhood and asymptomatic X-linked adrenoleukodystrophy: Lorenzo's oil effect.
Metabolic brain disease 2008;23(1):43-9.
2008: Guilhian Leipnitz; Bianca Seminotti; Josué Haubrich; Manuela B Dalcin; Karina B Dalcin; Alexandre Solano; Giorgia de Bortoli; Rafael B Rosa; Alexandre U Amaral; Carlos Severo Dutra-Filho; Alexandra Latini; Moacir Wajner
Evidence that 3-hydroxy-3-methylglutaric acid promotes lipid and protein oxidative damage and reduces the nonenzymatic antioxidant defenses in rat cerebral cortex.
Journal of neuroscience research 2008;86(3):683-93.
2008: S R Mirandola; D R Melo; P F Schuck; G C Ferreira; Moacir Wajner; Roger F Castilho
Methylmalonate inhibits succinate-supported oxygen consumption by interfering with mitochondrial succinate uptake.
Journal of inherited metabolic disease 2008;31(1):44-54.
2008: César A J Ribeiro; Angela M Sgaravatti; Rafael B Rosa; Patrícia F Schuck; Vanessa Grando; Anna L Schmidt; Gustavo C Ferreira; Marcos L S Perry; Carlos Severo Dutra-Filho; Moacir Wajner
Inhibition of brain energy metabolism by the branched-chain amino acids accumulating in maple syrup urine disease.
Neurochemical research 2008;33(1):114-24.
2007: Rafael B Rosa; Karina B Dalcin; Anna L Schmidt; Daniéli Gerhardt; César A J Ribeiro; Gustavo C Ferreira; Patrícia F Schuck; Angela T S Wyse; Lisiane O Porciúncula; Susana Wofchuk; Christianne Salbego; Diogo O Souza; Moacir Wajner
Evidence that glutaric acid reduces glutamate uptake by cerebral cortex of infant rats.
Life sciences 2007;81(25-26):1668-76.
2007: Patrícia F Schuck; Paula C Ceolato; Gustavo C Ferreira; Anelise Tonin; Guilhian Leipnitz; Carlos Severo Dutra-Filho; Alexandra Latini; Moacir Wajner
Oxidative stress induction by cis-4-decenoic acid: relevance for MCAD deficiency.
Free radical research 2007;41(11):1261-72.
2007: Marion Deon; Angela Sitta; Alethéa G Barschak; Daniella M Coelho; Maiara Pigatto; Graziela O Schmitt; Laura B Jardim; Roberto Giugliani; Moacir Wajner; Carmen R Vargas
Induction of lipid peroxidation and decrease of antioxidant defenses in symptomatic and asymptomatic patients with X-linked adrenoleukodystrophy.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 2007;25(7):441-4.
2007: Alexandra Latini; Karina Scussiato; Guilhian Leipnitz; K M Gibson; Moacir Wajner
Evidence for oxidative stress in tissues derived from succinate semialdehyde dehydrogenase-deficient mice.
Journal of inherited metabolic disease 2007;30(5):800-10.
2007: Gustavo C Ferreira; Anelise Tonin; Patrícia F Schuck; Carolina M Viegas; Paula C Ceolato; Alexandra Latini; Marcos L S Perry; Angela T S Wyse; Carlos Severo Dutra-Filho; Clóvis M D Wannmacher; Carmen R Vargas; Moacir Wajner
Evidence for a synergistic action of glutaric and 3-hydroxyglutaric acids disturbing rat brain energy metabolism.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 2007;25(6):391-8.
2007: Regina Pessoa Pureur; Moacir Wajner
Cytoskeleton as a potential target in the neuropathology of maple syrup urine disease: insight from animal studies.
Journal of inherited metabolic disease 2007;30(5):664-72.
2007: Cláudia Funchal; Francine Tramontina; André Quincozes dos Santos; Daniela Fraga de Souza; Carlos-Alberto Gonçalves; Regina Pessoa Pureur; Moacir Wajner
Effect of the branched-chain alpha-keto acids accumulating in maple syrup urine disease on S100B release from glial cells.
Journal of the neurological sciences 2007;260(1-2):87-94.
2007: Karina B Dalcin; Rafael B Rosa; Anna L Schmidt; Juliana S Winter; Guilhian Leipnitz; Carlos Severo Dutra-Filho; Clóvis M D Wannmacher; Lisiane O Porciúncula; Diogo O Souza; Moacir Wajner
Age and brain structural related effects of glutaric and 3-hydroxyglutaric acids on glutamate binding to plasma membranes during rat brain development.
Cellular and molecular neurobiology 2007;27(6):805-18.
2007: Carolina D Pederzolli; Caroline P Mescka; Fernanda Scapin; Francieli J Rockenbach; Angela M Sgaravatti; Mirian B Sgarbi; Angela T S Wyse; Clóvis M D Wannmacher; Moacir Wajner; Carlos Severo Dutra-Filho
N-acetylaspartic acid promotes oxidative stress in cerebral cortex of rats.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 2007;25(5):317-24.
2007: Alethéa G Barschak; Angela Sitta; Marion Deon; Amanda T Barden; Graziela O Schmitt; Carlos Severo Dutra-Filho; Moacir Wajner; Carmen R Vargas
Erythrocyte glutathione peroxidase activity and plasma selenium concentration are reduced in maple syrup urine disease patients during treatment.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 2007;25(5):335-8.
2007: Virginia Cielo Rech; Luciane Rosa Feksa; Maria Fernanda Arevalo do Amaral; Gustavo Waltereith Koch; Moacir Wajner; Carlos Severo Dutra-Filho; Angela Terezinha de Souza Wyse; Clovis Milton Duval Wannmacher
Promotion of oxidative stress in kidney of rats loaded with cystine dimethyl ester.
Pediatric nephrology (Berlin, Germany) 2007;22(8):1121-8.
2007: César A J Ribeiro; Fabrício Balestro; Vanessa Grando; Moacir Wajner
Isovaleric acid reduces Na+, K+-ATPase activity in synaptic membranes from cerebral cortex of young rats.
Cellular and molecular neurobiology 2007;27(4):529-40.
2007: Alexandra I Zugno; Diogo L Oliveira; Emilene B S Scherer; Moacir Wajner; Susana Wofchuk; Angela T S Wyse
Guanidinoacetate inhibits glutamate uptake in rat striatum of rats at different ages.
Neurochemical research 2007;32(6):959-64.
2007: Alexandra Latini; Gustavo C Ferreira; Karina Scussiato; Patrícia F Schuck; Alexandre F Solano; Carlos Severo Dutra-Filho; Carmen R Vargas; Moacir Wajner
Induction of oxidative stress by chronic and acute glutaric acid administration to rats.
Cellular and molecular neurobiology 2007;27(4):423-38.
2007: Alexandra I Zugno; Emilene B S Scherer; Cristiane B Mattos; César A J Ribeiro; Clóvis M D Wannmacher; Moacir Wajner; Angela T S Wyse
Evidence that the inhibitory effects of guanidinoacetate on the activities of the respiratory chain, Na+,K+-ATPase and creatine kinase can be differentially prevented by taurine and vitamins E and C administration in rat striatum in vivo.
Biochimica et biophysica acta 2007;1772(5):563-9.
2007: Priscila de Lima Pelaez; Cláudia Funchal; Samanta Oliveira Loureiro; Luana Heimfarth; Ariane Zamoner; Carmem Gottfried; Alexandra Latini; Moacir Wajner; Regina Pessoa Pureur
Branched-chain amino acids accumulating in maple syrup urine disease induce morphological alterations in C6 glioma cells probably through reactive species.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 2007;25(3):181-9.
2007: Alessandro Wajner; Cristiane Bürger; Carlos Severo Dutra-Filho; Moacir Wajner; Angela Terezinha de Souza Wyse; Clóvis M D Wannmacher
Synaptic plasma membrane Na(+), K (+)-ATPase activity is significantly reduced by the alpha-keto acids accumulating in maple syrup urine disease in rat cerebral cortex.
Metabolic brain disease 2007;22(1):77-88.
2007: Carolina D Pederzolli; Angela M Sgaravatti; César A Braum; Cristina C Prestes; Giovanni K Zorzi; Mirian B Sgarbi; Angela T S Wyse; Clóvis M D Wannmacher; Moacir Wajner; Carlos Severo Dutra-Filho
5-Oxoproline reduces non-enzymatic antioxidant defenses in vitro in rat brain.
Metabolic brain disease 2007;22(1):51-65.
2007: Débora Delwing; Andrea R Cornélio; Moacir Wajner; Clóvis M D Wannmacher; Angela T S Wyse
Arginine administration reduces creatine kinase activity in rat cerebellum.
Metabolic brain disease 2007;22(1):13-23.
2007: Gustavo da C Ferreira; Patrícia F Schuck; Carolina M Viegas; Anelise Tonin; Alexandra Latini; Carlos Severo Dutra-Filho; Angela T S Wyse; Clóvis M D Wannmacher; Carmen R Vargas; Moacir Wajner
Energy metabolism is compromised in skeletal muscle of rats chronically-treated with glutaric acid.
Metabolic brain disease 2007;22(1):111-23.
2007: Francieli M Stefanello; Cristiane Matté; Emilene B S Scherer; Clóvis M D Wannmacher; Moacir Wajner; Angela T S Wyse
Chemically induced model of hypermethioninemia in rats.
Journal of neuroscience methods 2007;160(1):1-4.
2007: Angela M Sgaravatti; Mirian B Sgarbi; Carla G Testa; Karina Durigon; Carolina D Pederzolli; Cristina C Prestes; Angela T S Wyse; Clóvis M D Wannmacher; Moacir Wajner; Carlos Severo Dutra-Filho
Gamma-hydroxybutyric acid induces oxidative stress in cerebral cortex of young rats.
Neurochemistry international 2007;50(3):564-70.
2007: Patrícia F Schuck; Anelise Tonin; Gustavo da Costa Ferreira; Carolina M Viegas; Alexandra Latini; Clovis Milton Duval Wannmacher; Angela Terezinha de Souza Wyse; Carlos Severo Dutra-Filho; Moacir Wajner
Kynurenines impair energy metabolism in rat cerebral cortex.
Cellular and molecular neurobiology 2007;27(1):147-60.
2007: Patrícia F Schuck; Anelise Tonin; Gustavo da Costa Ferreira; Rafael B Rosa; Alexandra Latini; Fabrício Balestro; Marcos L S Perry; Clóvis M D Wannmacher; Angela Terezinha de Souza Wyse; Moacir Wajner
In vitro effect of quinolinic acid on energy metabolism in brain of young rats.
Neuroscience research 2007;57(2):277-88.
2007: Guilhian Leipnitz; Cristiana Schumacher; Karina B Dalcin; Karina Scussiato; Alexandre Solano; Cláudia Funchal; Carlos Severo Dutra-Filho; Angela T S Wyse; Clóvis M D Wannmacher; Alexandra Latini; Moacir Wajner
In vitro evidence for an antioxidant role of 3-hydroxykynurenine and 3-hydroxyanthranilic acid in the brain.
Neurochemistry international 2007;50(1):83-94.
2006: Andrea Renata Cornelio; Valnes Rodrigues Junior; Virginia Cielo Rech; Angela Terezinha de Souza Wyse; Carlos Severo Dutra-Filho; Moacir Wajner; Clóvis M D Wannmacher
Inhibition of creatine kinase activity from rat cerebral cortex by 3-hydroxykynurenine.
Brain research 2006;1124(1):188-96.
2006: César A J Ribeiro; Vanessa Grando; Carlos Severo Dutra-Filho; Clóvis M D Wannmacher; Moacir Wajner
Evidence that quinolinic acid severely impairs energy metabolism through activation of NMDA receptors in striatum from developing rats.
Journal of neurochemistry 2006;99(6):1531-42.
2006: Angela Sitta; Alethéa G Barschak; Marion Deon; T Terroso; R Pires; Roberto Giugliani; Carlos Severo Dutra-Filho; Moacir Wajner; Carmen R Vargas
Investigation of oxidative stress parameters in treated phenylketonuric patients.
Metabolic brain disease 2006;21(4):287-96.
2006: Alethéa G Barschak; Angela Sitta; Marion Deon; Marcella H de Oliveira; Alexsandro Haeser; Carlos Severo Dutra-Filho; Moacir Wajner; Carmen R Vargas
Evidence that oxidative stress is increased in plasma from patients with maple syrup urine disease.
Metabolic brain disease 2006;21(4):279-86.
2006: Cláudia Funchal; Alexandra Latini; Maria Caroline Jacques-Silva; André Quincozes dos Santos; Luciane Buzin; Carmem Gottfried; Moacir Wajner; Regina Pessoa Pureur
Morphological alterations and induction of oxidative stress in glial cells caused by the branched-chain alpha-keto acids accumulating in maple syrup urine disease.
Neurochemistry international 2006;49(7):640-50.
2006: Caren S Bavaresco; Fábria Chiarani; Moacir Wajner; Carlos Alexandre Netto; Angela Terezinha de Souza Wyse
Intrastriatal hypoxanthine administration affects Na+,K+-ATPase, acetylcholinesterase and catalase activities in striatum, hippocampus and cerebral cortex of rats.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 2006;24(7):411-7.
2006: Marion Deon; Moacir Wajner; Lisana R Sirtori; Douglas Fitarelli; Daniella M Coelho; Angela Sitta; Alethéa G Barschak; Gustavo C Ferreira; Alexsandro Haeser; Roberto Giugliani; Carmen R Vargas
The effect of Lorenzo's oil on oxidative stress in X-linked adrenoleukodystrophy.
Journal of the neurological sciences 2006;247(2):157-64.
2006: Raquel Bridi; Fernanda Urruth Fontella; Vânia Pulrolnik; César A Braun; Giovanni K Zorzi; Daniella de Moura Coelho; Moacir Wajner; Carmen R Vargas; Carlos Severo Dutra-Filho
A chemically-induced acute model of maple syrup urine disease in rats for neurochemical studies.
Journal of neuroscience methods 2006;155(2):224-30.
2006: Virginia Cielo Rech; Genaro Azambuja Athaydes; Luciane Rosa Feksa; Paula Karine Barcelos Dornelles; Valnes Rodrigues Junior; Carlos Severo Dutra-Filho; Angela Terezinha de Souza Wyse; Moacir Wajner; Clóvis M D Wannmacher
Inhibition of creatine kinase activity by cystine in the kidney of young rats.
Pediatric research 2006;60(2):190-5.
2006: Luciane Rosa Feksa; Alexandra Latini; Virginia Cielo Rech; Moacir Wajner; Carlos Severo Dutra-Filho; Angela Terezinha de Souza Wyse; Clóvis M D Wannmacher
Promotion of oxidative stress by L-tryptophan in cerebral cortex of rats.
Neurochemistry international 2006;49(1):87-93.
2006: Stefan Kölker; Sven F Garbade; Cheryl R Greenberg; James V Leonard; Jean-Marie Saudubray; Antonia Ribes; H Serap Kalkanoglu; Allan M Lund; Begoña Merinero; Moacir Wajner; Mónica Troncoso; Monique Williams; John H Walter; Jaume Campistol; Milagros Martí-Herrero; Melissa Caswill; Alberto Burlina; Florian Lagler; Esther M Maier; Bernd Schwahn; Aysegul Tokatli; Ali Dursun; Turgay Coskun; Ronald A Chalmers; David M Koeller; Johannes Zschocke; Ernst Christensen; Peter Burgard; Georg F Hoffmann
Natural history, outcome, and treatment efficacy in children and adults with glutaryl-CoA dehydrogenase deficiency.
Pediatric research 2006;59(6):840-7.
2006: V Vasques; Fabrício Brinco; Carolina M Viegas; Moacir Wajner
Creatine prevents behavioral alterations caused by methylmalonic acid administration into the hippocampus of rats in the open field task.
Journal of the neurological sciences 2006;244(1-2):23-9.
2006: Cristina C Prestes; Angela M Sgaravatti; Carolina D Pederzolli; Mirian B Sgarbi; Giovanni K Zorzi; Clóvis M D Wannmacher; Moacir Wajner; Angela T S Wyse; Carlos Severo Dutra-Filho
Citrulline and ammonia accumulating in citrullinemia reduces antioxidant capacity of rat brain in vitro.
Metabolic brain disease 2006;21(1):63-74.
2006: Lúcia Maria Vieira de Almeida; Cláudia Funchal; Carmem Gottfried; Moacir Wajner; Regina Pessoa Pureur
Propionic acid induces cytoskeletal alterations in cultured astrocytes from rat cerebral cortex.
Metabolic brain disease 2006;21(1):51-62.
2006: Alexandra I Zugno; Emilene B S Scherer; Patrícia F Schuck; Diogo L Oliveira; Susana Wofchuk; Clóvis M D Wannmacher; Moacir Wajner; Angela T S Wyse
Intrastriatal administration of guanidinoacetate inhibits Na+, K+-ATPase and creatine kinase activities in rat striatum.
Metabolic brain disease 2006;21(1):41-50.
2006: Gustavo da C Ferreira; Karina Roth André; Patrícia F Schuck; Carolina M Viegas; Anelise Tonin; Daniella de Moura Coelho; Angela T S Wyse; Clóvis M D Wannmacher; Carmen R Vargas; Moacir Wajner
Effect of in vivo administration of ethylmalonic acid on energy metabolism in rat tissues.
Metabolic brain disease 2006;21(1):29-39.
2006: Alethéa G Barschak; Gustavo da C Ferreira; Karina R André; Patrícia F Schuck; Carolina M Viegas; Anelise Tonin; Carlos Severo Dutra-Filho; Angela T S Wyse; Clóvis M D Wannmacher; Carmen R Vargas; Moacir Wajner
Inhibition of the electron transport chain and creatine kinase activity by ethylmalonic acid in human skeletal muscle.
Metabolic brain disease 2006;21(1):11-9.
2006: Débora Delwing; Bárbara Tagliari; Fábria Chiarani; Clóvis M D Wannmacher; Moacir Wajner; Angela T S Wyse
Alpha-tocopherol and ascorbic acid administration prevents the impairment of brain energy metabolism of hyperargininemic rats.
Cellular and molecular neurobiology 2006;26(2):177-89.
2006: Cláudia Funchal; Patrícia F Schuck; André Quincozes Dos Santos; Maria Caroline Jacques-Silva; Carmem Gottfried; Regina Pessoa Pureur; Moacir Wajner
Creatine and antioxidant treatment prevent the inhibition of creatine kinase activity and the morphological alterations of C6 glioma cells induced by the branched-chain alpha-keto acids accumulating in maple syrup urine disease.
Cellular and molecular neurobiology 2006;26(1):67-79.
2006: Cristiane Matté; Eduardo Durigon; Francieli M Stefanello; Franciele Cipriani; Moacir Wajner; Angela T S Wyse
Folic acid pretreatment prevents the reduction of Na(+),K(+)-ATPase and butyrylcholinesterase activities in rats subjected to acute hyperhomocysteinemia.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 2006;24(1):3-8.
2006: Leticia F Pettenuzzo; Gustavo da C Ferreira; Anna L Schmidt; Carlos Severo Dutra-Filho; Angela T S Wyse; Moacir Wajner
Differential inhibitory effects of methylmalonic acid on respiratory chain complex activities in rat tissues.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 2006;24(1):45-52.
2006: Dênis R de Assis; R C Maria; Gustavo C Ferreira; Patrícia F Schuck; Alexandra Latini; Carlos Severo Dutra-Filho; Clóvis M D Wannmacher; Angela T S Wyse; Moacir Wajner
Na+, K+ ATPase activity is markedly reduced by cis-4-decenoic acid in synaptic plasma membranes from cerebral cortex of rats.
Experimental neurology 2006;197(1):143-9.
2005: Gustavo da C Ferreira; Carolina M Viegas; Patrícia F Schuck; Alexandra Latini; Carlos Severo Dutra-Filho; Angela T S Wyse; Clóvis M D Wannmacher; Carmen R Vargas; Moacir Wajner
Glutaric acid moderately compromises energy metabolism in rat brain.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 2005;23(8):687-93.
2005: Guilhian Leipnitz; Cristiana Schumacher; Karina Scussiato; Karina B Dalcin; Clóvis M D Wannmacher; Angela T S Wyse; Carlos Severo Dutra-Filho; Moacir Wajner; Alexandra Latini
Quinolinic acid reduces the antioxidant defenses in cerebral cortex of young rats.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 2005;23(8):695-701.
2005: Cláudia Funchal; Ariane Zamoner; André Quincozes dos Santos; Maria Beatriz Moretto; João B T Rocha; Moacir Wajner; Regina Pessoa Pureur
Evidence that intracellular Ca2+ mediates the effect of alpha-ketoisocaproic acid on the phosphorylating system of cytoskeletal proteins from cerebral cortex of immature rats.
Journal of the neurological sciences 2005;238(1-2):75-82.
2005: Francieli M Stefanello; Fábria Chiarani; Andréa G Kurek; Clóvis M D Wannmacher; Moacir Wajner; Angela T S Wyse
Methionine alters Na+,K+-ATPase activity, lipid peroxidation and nonenzymatic antioxidant defenses in rat hippocampus.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 2005;23(7):651-6.
2005: Luciane Rosa Feksa; Andrea Renata Cornelio; Carlos Severo Dutra-Filho; Angela T S Wyse; Moacir Wajner; Clóvis M D Wannmacher
The effects of the interactions between amino acids on pyruvate kinase activity from the brain cortex of young rats.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 2005;23(6):509-14.
2005: Cláudia Funchal; Ariane Zamoner; André Quincozes dos Santos; Samanta Oliveira Loureiro; Moacir Wajner; Regina Pessoa Pureur
Alpha-ketoisocaproic acid increases phosphorylation of intermediate filament proteins from rat cerebral cortex by mechanisms involving Ca2+ and cAMP.
Neurochemical research 2005;30(9):1139-46.
2005: Gustavo da C Ferreira; Carolina M Viegas; Patrícia F Schuck; Anelise Tonin; César A J Ribeiro; Daniella de Moura Coelho; Teresa Dalla Costa; Alexandra Latini; Angela T S Wyse; Clóvis M D Wannmacher; Carmen R Vargas; Moacir Wajner
Glutaric acid administration impairs energy metabolism in midbrain and skeletal muscle of young rats.
Neurochemical research 2005;30(9):1123-31.
2005: Cláudia Funchal; André Quincozes dos Santos; Maria Caroline Jacques-Silva; Ariane Zamoner; Carmem Gottfried; Moacir Wajner; Regina Pessoa Pureur
Branched-chain alpha-keto acids accumulating in maple syrup urine disease induce reorganization of phosphorylated GFAP in C6-glioma cells.
Metabolic brain disease 2005;20(3):205-17.
2005: Alexandra Latini; Cleide G da Silva; Gustavo C Ferreira; Patrícia F Schuck; Karina Scussiato; João José Freitas Sarkis; Carlos Severo Dutra-Filho; Angela T S Wyse; Clóvis M D Wannmacher; Moacir Wajner
Mitochondrial energy metabolism is markedly impaired by D-2-hydroxyglutaric acid in rat tissues.
Molecular genetics and metabolism 2005;86(1-2):188-99.
2005: Cláudia Funchal; Carmem Gottfried; Lúcia Maria Vieira de Almeida; André Quincozes dos Santos; Moacir Wajner; Regina Pessoa Pureur
Morphological alterations and cell death provoked by the branched-chain alpha-amino acids accumulating in maple syrup urine disease in astrocytes from rat cerebral cortex.
Cellular and molecular neurobiology 2005;25(5):851-67.
2005: Samanta Oliveira Loureiro; Priscila de Lima Pelaez; Luana Heimfarth; Diogo O Souza; Moacir Wajner; Regina Pessoa Pureur
Propionic and methylmalonic acids increase cAMP levels in slices of cerebral cortex of young rats via adrenergic and glutamatergic mechanisms.
Biochimica et biophysica acta 2005;1740(3):460-6.
2005: Raquel Bridi; César A Braun; Giovanni K Zorzi; Clóvis M D Wannmacher; Moacir Wajner; Eduardo G Lissi; Carlos Severo Dutra-Filho
alpha-keto acids accumulating in maple syrup urine disease stimulate lipid peroxidation and reduce antioxidant defences in cerebral cortex from young rats.
Metabolic brain disease 2005;20(2):155-67.
2005: Francieli M Stefanello; Renata Franzon; Bárbara Tagliari; Clóvis M D Wannmacher; Moacir Wajner; Angela T S Wyse
Reduction of butyrylcholinesterase activity in rat serum subjected to hyperhomocysteinemia.
Metabolic brain disease 2005;20(2):97-103.
2005: Vilson de Castro Vasques; Fabrício Brinco; Moacir Wajner
Intrahippocampal administration of the branched-chain alpha-hydroxy acids accumulating in maple syrup urine disease compromises rat performance in aversive and non-aversive behavioral tasks.
Journal of the neurological sciences 2005;232(1-2):11-21.
2005: Débora Delwing; Fábria Chiarani; Caren S Bavaresco; Clóvis M D Wannmacher; Moacir Wajner; Carlos Severo Dutra-Filho; Angela T S Wyse
Protective effect of antioxidants on brain oxidative damage caused by proline administration.
Neuroscience research 2005;52(1):69-74.
2005: Débora Delwing; Fábria Chiarani; Clóvis M D Wannmacher; Moacir Wajner; Angela T S Wyse
Effect of hyperprolinemia on acetylcholinesterase and butyrylcholinesterase activities in rat.
Amino acids 2005;28(3):305-8.
2005: Caren S Bavaresco; Fábria Chiarani; Cristiane Matté; Moacir Wajner; Carlos Alexandre Netto; Angela Terezinha de Souza Wyse
Effect of hypoxanthine on Na+,K+-ATPase activity and some parameters of oxidative stress in rat striatum.
Brain research 2005;1041(2):198-204.
2005: Lisana R Sirtori; Carlos Severo Dutra-Filho; D Fitarelli; Angela Sitta; Alexsandro Haeser; Alethéa G Barschak; Moacir Wajner; Daniella M Coelho; Susana Llesuy; Adriane Belló-Klein; Roberto Giugliani; Marion Deon; Carmen R Vargas
Oxidative stress in patients with phenylketonuria.
Biochimica et biophysica acta 2005;1740(1):68-73.
2005: Rochele M Müller Fleck; Valnes Rodrigues Junior; Juliana Giacomazzi; Daiana Parissoto; Carlos Severo Dutra-Filho; Angela Terezinha de Souza Wyse; Moacir Wajner; Clóvis M D Wannmacher
Cysteamine prevents and reverses the inhibition of creatine kinase activity caused by cystine in rat brain cortex.
Neurochemistry international 2005;46(5):391-7.
2005: Alexandra Latini; M Rodriguez; Rafael Borba Rosa; Karina Scussiato; Guilhian Leipnitz; D Reis de Assis; Gustavo da Costa Ferreira; Cláudia Funchal; Maria Caroline Jacques-Silva; L Buzin; Roberto Giugliani; Adriana Cassina; Rafael Radi; Moacir Wajner
3-Hydroxyglutaric acid moderately impairs energy metabolism in brain of young rats.
Neuroscience 2005;135(1):111-20.
2005: Rafael B Rosa; Patrícia F Schuck; Dênis R de Assis; Alexandra Latini; Karina B Dalcin; César A J Ribeiro; G da C Ferreira; R C Maria; Guilhian Leipnitz; Marcos L S Perry; C S Dutra Filho; Angela T S Wyse; Clóvis M D Wannmacher; Moacir Wajner
Inhibition of energy metabolism by 2-methylacetoacetate and 2-methyl-3-hydroxybutyrate in cerebral cortex of developing rats.
Journal of inherited metabolic disease 2005;28(4):501-15.
2005: Alexandra Latini; Karina Scussiato; Guilhian Leipnitz; Carlos Severo Dutra-Filho; Moacir Wajner
Promotion of oxidative stress by 3-hydroxyglutaric acid in rat striatum.
Journal of inherited metabolic disease 2005;28(1):57-67.
2004: Dênis Reis de Assis; Rita de Cássia Maria; Rafael Borba Rosa; Patrícia F Schuck; César A J Ribeiro; Gustavo da Costa Ferreira; Carlos Severo Dutra-Filho; Angela Terezinha de Souza Wyse; Clovis Milton Duval Wannmacher; Marcos Luiz Santos Perry; Moacir Wajner
Inhibition of energy metabolism in cerebral cortex of young rats by the medium-chain fatty acids accumulating in MCAD deficiency.
Brain research 2004;1030(1):141-51.
2004: Rafael B Rosa; Carolina Schwarzbold; Karina B Dalcin; Gabrielle C Ghisleni; César A J Ribeiro; Maria Beatriz Moretto; Marcos E S Frizzo; Georg F Hoffmann; Diogo O Souza; Moacir Wajner
Evidence that 3-hydroxyglutaric acid interacts with NMDA receptors in synaptic plasma membranes from cerebral cortex of young rats.
Neurochemistry international 2004;45(7):1087-94.
2004: Lisiane O Porciúncula; Tatiana Emanuelli; Rejane G Tavares; Carolina Schwarzbold; Marcos E S Frizzo; Diogo O Souza; Moacir Wajner
Glutaric acid stimulates glutamate binding and astrocytic uptake and inhibits vesicular glutamate uptake in forebrain from young rats.
Neurochemistry international 2004;45(7):1075-86.
2004: Cláudia Funchal; Carmem Gottfried; Lúcia Maria Vieira de Almeida; Moacir Wajner; Regina Pessoa Pureur
Evidence that the branched-chain alpha-keto acids accumulating in maple syrup urine disease induce morphological alterations and death in cultured astrocytes from rat cerebral cortex.
Glia 2004;48(3):230-40.
2004: Patrícia F Schuck; Rafael B Rosa; Leticia F Pettenuzzo; Angela Sitta; Clóvis M D Wannmacher; Angela T S Wyse; Moacir Wajner
Inhibition of mitochondrial creatine kinase activity from rat cerebral cortex by methylmalonic acid.
Neurochemistry international 2004;45(5):661-7.
2004: Evelise N Maciel; Alicia J Kowaltowski; Fábio D Schwalm; Juliana M Rodrigues; Diogo O Souza; Anibal E Vercesi; Moacir Wajner; Roger F Castilho
Mitochondrial permeability transition in neuronal damage promoted by Ca2+ and respiratory chain complex II inhibition.
Journal of neurochemistry 2004;90(5):1025-35.
2004: Tatiana Galetto Rosa; Angela Terezinha de Souza Wyse; Moacir Wajner; Clóvis M D Wannmacher
Cysteamine prevents and reverses the inhibition of pyruvate kinase activity caused by cystine in rat heart.
Biochimica et biophysica acta 2004;1689(2):114-9.
2004: Luciane Rosa Feksa; Andrea Renata Cornelio; Carlos Severo Dutra-Filho; Angela Terezinha de Souza Wyse; Moacir Wajner; Clóvis M D Wannmacher
Inhibition of pyruvate kinase activity by cystine in brain cortex of rats.
Brain research 2004;1012(1-2):93-100.
2004: Alexandra I Zugno; Renata Franzon; Fábria Chiarani; Caren S Bavaresco; Clóvis M D Wannmacher; Moacir Wajner; Angela T S Wyse
Evaluation of the mechanism underlying the inhibitory effect of guanidinoacetate on brain Na+, K+-ATPase activity.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 2004;22(4):191-6.
2004: Cláudia Funchal; Aline Meyer Rosa; Moacir Wajner; Susana Wofchuk; Regina Pessoa Pureur
Reduction of glutamate uptake into cerebral cortex of developing rats by the branched-chain alpha-keto acids accumulating in maple syrup urine disease.
Neurochemical research 2004;29(4):747-53.
2004: Andrea Renata Cornelio; Valnês Rodrigues; Angela Terezinha de Souza Wyse; Carlos Severo Dutra-Filho; Moacir Wajner; Clóvis M D Wannmacher
Tryptophan reduces creatine kinase activity in the brain cortex of rats.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 2004;22(2):95-101.
2004: C M Tansini; Karina Durigon; Carla G Testa; Adriane Belló-Klein; Moacir Wajner; Clóvis M D Wannmacher; Angela T S Wyse; Carlos Severo Dutra-Filho
Effects of histidine and imidazolelactic acid on various parameters of the oxidative stress in cerebral cortex of young rats.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 2004;22(2):67-72.
2004: Marcos E S Frizzo; Carolina Schwarzbold; Lisiane O Porciúncula; Karina B Dalcin; Rafael B Rosa; César A J Ribeiro; Diogo O Souza; Moacir Wajner
3-hydroxyglutaric acid enhances glutamate uptake into astrocytes from cerebral cortex of young rats.
Neurochemistry international 2004;44(5):345-53.
2004: Débora Junqueira; Ana M Brusque; Lisiane O Porciúncula; Liane N Rotta; Marcos E S Frizzo; Angela T S Wyse; Clóvis M D Wannmacher; Diogo O Souza; Moacir Wajner
In vitro effects of D-2-hydroxyglutaric acid on glutamate binding, uptake and release in cerebral cortex of rats.
Journal of the neurological sciences 2004;217(2):189-94.
2004: Caren S Bavaresco; Alexandra I Zugno; Bárbara Tagliari; Clóvis M D Wannmacher; Moacir Wajner; Angela T S Wyse
Inhibition of Na+, K+-ATPase activity in rat striatum by the metabolites accumulated in Lesch-Nyhan disease.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 2004;22(1):11-7.
2004: Angela T S Wyse; Francieli M Stefanello; Fábria Chiarani; Débora Delwing; Clóvis M D Wannmacher; Moacir Wajner
Arginine administration decreases cerebral cortex acetylcholinesterase and serum butyrylcholinesterase probably by oxidative stress induction.
Neurochemical research 2004;29(2):385-9.
2004: Carmen R Vargas; Moacir Wajner; Lisana R Sirtori; L Goulart; M Chiochetta; Daniella de Moura Coelho; Alexandra Latini; Susana Llesuy; A Bello-Klein; Roberto Giugliani; Marion Deon; Carlos Fernando Mello
Evidence that oxidative stress is increased in patients with X-linked adrenoleukodystrophy.
Biochimica et biophysica acta 2004;1688(1):26-32.
2004: Cláudia Funchal; Franciele Dall Bello Pessutto; Lúcia Maria Vieira de Almeida; Priscila de Lima Pelaez; Samanta Oliveira Loureiro; Lilian Vivian; Moacir Wajner; Regina Pessoa Pureur
Alpha-keto-beta-methylvaleric acid increases the in vitro phosphorylation of intermediate filaments in cerebral cortex of young rats through the gabaergic system.
Journal of the neurological sciences 2004;217(1):17-24.
2004: Moacir Wajner; Stefan Kölker; Diogo O Souza; G F Hoffmann; CF de Mello
Modulation of glutamatergic and GABAergic neurotransmission in glutaryl-CoA dehydrogenase deficiency.
Journal of inherited metabolic disease 2004;27(6):825-8.
2004: David M Koeller; Sven W Sauer; Moacir Wajner; CF de Mello; Stephen I Goodman; Michael Woontner; Chris Mühlhausen; Jürgen G Okun; Stefan Kölker
Animal models for glutaryl-CoA dehydrogenase deficiency.
Journal of inherited metabolic disease 2004;27(6):813-8.
2004: Moacir Wajner; A Latini; Angela T S Wyse; Carlos Severo Dutra-Filho
The role of oxidative damage in the neuropathology of organic acidurias: insights from animal studies.
Journal of inherited metabolic disease 2004;27(4):427-48.
2004: Vilson de Castro Vasques; Melissa Avila de Boer; Felipe Diligenti; Fabrício Brinco; Fabrício Mallmann; Carlos Fernando Mello; Moacir Wajner
Intrahippocampal administration of the alpha-keto acids accumulating in maple syrup urine disease provokes learning deficits in rats.
Pharmacology, biochemistry, and behavior 2004;77(1):183-90.
2004: Cleide G da Silva; Ana Rúbia F Bueno; Patrícia F Schuck; Guilhian Leipnitz; César A J Ribeiro; Rafael B Rosa; Carlos Severo Dutra-Filho; Angela T S Wyse; Clóvis M D Wannmacher; Moacir Wajner
Inhibition of creatine kinase activity from rat cerebral cortex by D-2-hydroxyglutaric acid in vitro.
Neurochemistry international 2004;44(1):45-52.
2003: Francieli M Stefanello; Renata Franzon; Clóvis M D Wannmacher; Moacir Wajner; Angela T S Wyse
In vitro homocysteine inhibits platelet Na+,K+-ATPase and serum butyrylcholinesterase activities of young rats.
Metabolic brain disease 2003;18(4):273-80.
2003: Débora Delwing; Caren S Bavaresco; Fábria Chiarani; Clóvis M D Wannmacher; Moacir Wajner; Carlos Severo Dutra-Filho; Angela Terezinha de Souza Wyse
In vivo and in vitro effects of proline on some parameters of oxidative stress in rat brain.
Brain research 2003;991(1-2):180-6.
2003: Angela M Sgaravatti; Rafael B Rosa; Patrícia F Schuck; César A J Ribeiro; Clóvis M D Wannmacher; Angela T S Wyse; Carlos Severo Dutra-Filho; Moacir Wajner
Inhibition of brain energy metabolism by the alpha-keto acids accumulating in maple syrup urine disease.
Biochimica et biophysica acta 2003;1639(3):232-8.
2003: Emilio Streck; Débora Delwing; Bárbara Tagliari; Cristiane Matté; Clóvis M D Wannmacher; Moacir Wajner; Angela T S Wyse
Brain energy metabolism is compromised by the metabolites accumulating in homocystinuria.
Neurochemistry international 2003;43(6):597-602.
2003: Leticia F Pettenuzzo; Angela T S Wyse; Clóvis M D Wannmacher; Carlos Severo Dutra-Filho; Carlos Alexandre Netto; Moacir Wajner
Evaluation of the effect of chronic administration of drugs on rat behavior in the water maze task.
Brain research. Brain research protocols 2003;12(2):109-15.
2003: Cleide G da Silva; Ana Rúbia F Bueno; Patrícia F Schuck; Guilhian Leipnitz; César A J Ribeiro; Clóvis M D Wannmacher; Angela T S Wyse; Moacir Wajner
D-2-hydroxyglutaric acid inhibits creatine kinase activity from cardiac and skeletal muscle of young rats.
European journal of clinical investigation 2003;33(10):840-7.
2003: Alexandra Latini; Karina Scussiato; Rafael B Rosa; Guilhian Leipnitz; Susana Llesuy; Adriane Belló-Klein; Carlos Severo Dutra-Filho; Moacir Wajner
Induction of oxidative stress by L-2-hydroxyglutaric acid in rat brain.
Journal of neuroscience research 2003;74(1):103-10.
2003: Raquel Bridi; Janaína Araldi; Mirian B Sgarbi; Carla G Testa; Karina Durigon; Moacir Wajner; Carlos Severo Dutra-Filho
Induction of oxidative stress in rat brain by the metabolites accumulating in maple syrup urine disease.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 2003;21(6):327-32.
2003: Renata Franzon; Marcelo L Lamers; Francieli M Stefanello; Clóvis M D Wannmacher; Moacir Wajner; Angela T S Wyse
Evidence that oxidative stress is involved in the inhibitory effect of proline on Na(+),K(+)-ATPase activity in synaptic plasma membrane of rat hippocampus.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 2003;21(6):303-7.
2003: Débora Delwing; Bárbara Tagliari; Emilio Streck; Clovis Milton Duval Wannamacher; Moacir Wajner; Angela T S Wyse
Reduction of energy metabolism in rat hippocampus by arginine administration.
Brain research 2003;983(1-2):58-63.
2003: Débora Junqueira; Ana M Brusque; Lisiane O Porciúncula; Liane N Rotta; César A J Ribeiro; Marcos E S Frizzo; Carlos Severo Dutra-Filho; Clóvis M D Wannmacher; Angela T S Wyse; Diogo O Souza; Moacir Wajner
Effects of L-2-hydroxyglutaric acid on various parameters of the glutamatergic system in cerebral cortex of rats.
Metabolic brain disease 2003;18(3):233-43.
2003: Lúcia Maria Vieira de Almeida; Cláudia Funchal; Priscila de Lima Pelaez; Franciele Dall Bello Pessutto; Samanta Oliveira Loureiro; Lilian Vivian; Moacir Wajner; Regina Pessoa Pureur
Effect of propionic and methylmalonic acids on the in vitro phosphorylation of intermediate filaments from cerebral cortex of rats during development.
Metabolic brain disease 2003;18(3):207-19.
2003: Francieli M Stefanello; Alexandra I Zugno; Clóvis M D Wannmacher; Moacir Wajner; Angela T S Wyse
Homocysteine inhibits butyrylcholinesterase activity in rat serum.
Metabolic brain disease 2003;18(3):187-94.
2003: Cleide G da Silva; Ana Rúbia F Bueno; Rafael B Rosa; Carlos Severo Dutra-Filho; Clóvis M D Wannmacher; Angela T S Wyse; Moacir Wajner
Inhibition of mitochondrial creatine kinase activity by D-2-hydroxyglutaric acid in cerebellum of young rats.
Neurochemical research 2003;28(9):1329-37.
2003: Dênis R de Assis; César A J Ribeiro; Rafael B Rosa; Patrícia F Schuck; Karina B Dalcin; Carmen R Vargas; Clóvis M D Wannmacher; Carlos Severo Dutra-Filho; Angela T S Wyse; Paz Briones; Moacir Wajner
Evidence that antioxidants prevent the inhibition of Na+,K(+)-ATPase activity induced by octanoic acid in rat cerebral cortex in vitro.
Neurochemical research 2003;28(8):1255-63.
2003: Adriana Kessler; Elisa Costabeber; Carlos Severo Dutra-Filho; Angela T S Wyse; Moacir Wajner; Clóvis M D Wannmacher
Proline reduces creatine kinase activity in the brain cortex of rats.
Neurochemical research 2003;28(8):1175-80.
2003: Leticia F Pettenuzzo; Patrícia F Schuck; Angela T S Wyse; Clóvis M D Wannmacher; Carlos Severo Dutra-Filho; Carlos Alexandre Netto; Moacir Wajner
Ascorbic acid prevents water maze behavioral deficits caused by early postnatal methylmalonic acid administration in the rat.
Brain research 2003;976(2):234-42.
2003: Adriana Kessler; Elisa Costabeber; Carlos Severo Dutra-Filho; Angela T S Wyse; Moacir Wajner; Clóvis M D Wannmacher
Effect of proline on creatine kinase activity in rat brain.
Metabolic brain disease 2003;18(2):169-77.
2003: Emilio Streck; Paula S Vieira; Clóvis M D Wannmacher; Carlos Severo Dutra-Filho; Moacir Wajner; Angela T S Wyse
In vitro effect of homocysteine on some parameters of oxidative stress in rat hippocampus.
Metabolic brain disease 2003;18(2):147-54.
2003: Luciane Rosa Feksa; Andrea Renata Cornelio; Carmen R Vargas; Angela Terezinha de Souza Wyse; Carlos Severo Dutra-Filho; Moacir Wajner; Clóvis M D Wannmacher
Alanine prevents the inhibition of pyruvate kinase activity caused by tryptophan in cerebral cortex of rats.
Metabolic brain disease 2003;18(2):129-37.
2003: Cleide G da Silva; Ana Rúbia F Bueno; Patrícia F Schuck; Guilhian Leipnitz; César A J Ribeiro; Clóvis M D Wannmacher; Angela T S Wyse; Moacir Wajner
L-2-hydroxyglutaric acid inhibits mitochondrial creatine kinase activity from cerebellum of developing rats.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 2003;21(4):217-24.
2003: Alexandra I Zugno; Francieli M Stefanello; Emilio Streck; Thiago Calcagnotto; Clóvis M D Wannmacher; Moacir Wajner; Angela T S Wyse
Inhibition of Na+, K+-ATPase activity in rat striatum by guanidinoacetate.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 2003;21(4):183-9.
2003: Caren S Bavaresco; Thiago Calcagnotto; Bárbara Tagliari; Débora Delwing; Marcelo L Lamers; Clóvis M D Wannmacher; Moacir Wajner; Angela T S Wyse
Brain Na+,K(+)-ATPase inhibition induced by arginine administration is prevented by vitamins E and C.
Neurochemical research 2003;28(6):825-9.
2003: Alexandra Latini; Karina Scussiato; Rafael B Rosa; Susana Llesuy; Adriane Belló-Klein; Carlos Severo Dutra-Filho; Moacir Wajner
D-2-hydroxyglutaric acid induces oxidative stress in cerebral cortex of young rats.
The European journal of neuroscience 2003;17(10):2017-22.
2003: Cláudia Funchal; Lúcia Maria Vieira de Almeida; Samanta Oliveira Loureiro; Lilian Vivian; Priscila de Lima Pelaez; Franciele Dall Bello Pessutto; Aline Meyer Rosa; Moacir Wajner; Regina Pessoa Pureur
In vitro phosphorylation of cytoskeletal proteins from cerebral cortex of rats.
Brain research. Brain research protocols 2003;11(2):111-8.
2003: Guilhian Leipnitz; Patrícia F Schuck; César A J Ribeiro; Karina B Dalcin; Dênis R Assis; Alethéa G Barschak; Vânia Pulrolnik; Clóvis M D Wannmacher; Angela T S Wyse; Moacir Wajner
Ethylmalonic acid inhibits mitochondrial creatine kinase activity from cerebral cortex of young rats in vitro.
Neurochemical research 2003;28(5):771-7.
2003: Carmen Pilla; Rui Felipe de Oliveira Cardozo; Carlos Severo Dutra-Filho; Angela T S Wyse; Moacir Wajner; Clóvis M D Wannmacher
Creatine kinase activity from rat brain is inhibited by branched-chain amino acids in vitro.
Neurochemical research 2003;28(5):675-9.
2003: Carmen Pilla; Rui Felipe de Oliveira Cardozo; Paula Karine Barcelos Dornelles; Carlos Severo Dutra-Filho; Angela T S Wyse; Moacir Wajner; Clóvis M D Wannmacher
Kinetic studies on the inhibition of creatine kinase activity by branched-chain alpha-amino acids in the brain cortex of rats.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 2003;21(3):145-51.
2003: Emilio Streck; Cristiane Matté; Paula S Vieira; Thiago Calcagnotto; Clóvis M D Wannmacher; Moacir Wajner; Angela T S Wyse
Impairment of energy metabolism in hippocampus of rats subjected to chemically-induced hyperhomocysteinemia.
Biochimica et biophysica acta 2003;1637(3):187-92.
2003: Rosane Gomez; Carmen R Vargas; Moacir Wajner; Helena M T Barros
Lower in vivo brain extracellular GABA concentration in diabetic rats during forced swimming.
Brain research 2003;968(2):281-4.
2003: Luciane Rosa Feksa; Andrea Renata Cornelio; Carlos Severo Dutra-Filho; Angela Terezinha de Souza Wyse; Moacir Wajner; Clóvis M D Wannmacher
Characterization of the inhibition of pyruvate kinase caused by phenylalanine and phenylpyruvate in rat brain cortex.
Brain research 2003;968(2):199-205.
2003: Elisa Costabeber; Adriana Kessler; Carlos Severo Dutra-Filho; Angela Terezinha de Souza Wyse; Moacir Wajner; Clóvis M D Wannmacher
Hyperphenylalaninemia reduces creatine kinase activity in the cerebral cortex of rats.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 2003;21(2):111-6.
2003: Débora Delwing; Caren S Bavaresco; Clóvis M D Wannmacher; Moacir Wajner; Carlos Severo Dutra-Filho; Angela T S Wyse
Proline induces oxidative stress in cerebral cortex of rats.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 2003;21(2):105-10.
2003: Maria da Graça Lütz; Luciane Rosa Feksa; Angela T S Wyse; Carlos Severo Dutra-Filho; Moacir Wajner; Clóvis M D Wannmacher
Alanine prevents the in vitro inhibition of glycolysis caused by phenylalanine in brain cortex of rats.
Metabolic brain disease 2003;18(1):87-94.
2003: Débora Delwing; Fábria Chiarani; Débora Delwing; Caren S Bavaresco; Clóvis M D Wannmacher; Moacir Wajner; Angela T S Wyse
Proline reduces acetylcholinesterase activity in cerebral cortex of rats.
Metabolic brain disease 2003;18(1):79-86.
2003: Carmen Pilla; Rui Felipe de Oliveira Cardozo; Carlos Severo Dutra-Filho; Angela T S Wyse; Moacir Wajner; Clóvis M D Wannmacher
Effect of leucine administration on creatine kinase activity in rat brain.
Metabolic brain disease 2003;18(1):17-25.
2003: Fernanda de Oliveira Marques; Martine Elisabeth Kienzle Hagen; Carolina D Pederzolli; Angela M Sgaravatti; Karina Durigon; Carla G Testa; Clóvis M D Wannmacher; Angela Terezinha de Souza Wyse; Moacir Wajner; Carlos Severo Dutra-Filho
Glutaric acid induces oxidative stress in brain of young rats.
Brain research 2003;964(1):153-8.
2003: Luiz Fernando Freire Royes; Michele Rechia Fighera; Ana Flávia Furian; Mauro Schneider Oliveira; L G Martins da Silva; Carlos Ricardo Maneck Malfatti; Paulo H Schneider; Antonio L Braga; Moacir Wajner; Carlos Fernando Mello
Creatine protects against the convulsive behavior and lactate production elicited by the intrastriatal injection of methylmalonate.
Neuroscience 2003;118(4):1079-90.
2002: Cláudia Funchal; Priscila de Lima Pelaez; Samanta Oliveira Loureiro; Lilian Vivian; Franciele Dall Bello Pessutto; Lúcia Maria Vieira de Almeida; Susana Tchernin Wofchuk; Moacir Wajner; Regina Pessoa Pureur
alpha-Ketoisocaproic acid regulates phosphorylation of intermediate filaments in postnatal rat cortical slices through ionotropic glutamatergic receptors.
Brain research. Developmental brain research 2002;139(2):267-76.
2002: Lilian Vivian; Franciele Dall Bello Pessutto; Lúcia Maria Vieira de Almeida; S de Oliveira Loureiro; Priscila de Lima Pelaez; Cláudia Funchal; Moacir Wajner; Regina Pessoa Pureur
Effect of propionic and methylmalonic acids on the high molecular weight neurofilament subunit (NF-H) in rat cerebral cortex.
Neurochemical research 2002;27(12):1691-7.
2002: Angela T S Wyse; Alexandra I Zugno; Emilio Streck; Cristiane Matté; Thiago Calcagnotto; Clóvis M D Wannmacher; Moacir Wajner
Inhibition of Na(+),K(+)-ATPase activity in hippocampus of rats subjected to acute administration of homocysteine is prevented by vitamins E and C treatment.
Neurochemical research 2002;27(12):1685-9.
2002: Patrícia F Schuck; Guilhian Leipnitz; César A J Ribeiro; Karina B Dalcin; Dênis R Assis; Alethéa G Barschak; Vânia Pulrolnik; Clóvis M D Wannmacher; Angela T S Wyse; Moacir Wajner
Inhibition of creatine kinase activity in vitro by ethylmalonic acid in cerebral cortex of young rats.
Neurochemical research 2002;27(12):1633-9.
2002: Emilio Streck; Cristiane Matte; Paula S Vieira; Fernanda Rombaldi; Clóvis M D Wannmacher; Moacir Wajner; Angela T S Wyse
Reduction of Na(+),K(+)-ATPase activity in hippocampus of rats subjected to chemically induced hyperhomocysteinemia.
Neurochemical research 2002;27(12):1593-8.
2002: Alexandra Latini; Rafael Borba Rosa; Karina Scussiato; Susana Llesuy; Adriane Belló-Klein; Moacir Wajner
3-Hydroxyglutaric acid induces oxidative stress and decreases the antioxidant defenses in cerebral cortex of young rats.
Brain research 2002;956(2):367-73.
2002: Moacir Wajner; Kimiyo Raymond; Alethéa G Barschak; Ana Paula Luft; Gustavo Ferreira; Gislane Domingues; Marina Chiochetta; Lisana R Sirtori; Laureci Goulart; Vânia Pulrolnik; Ricardo F Pires; Eugênio Grillo; Alfredo Lohr; Carolina Funayama; Maria Teresa Sanseverino; Júlio César Longuercio-Leite; Janice C Coelho; Roberto Giugliani; Carmen Regla-Vargas
Detection of organic acidemias in Brazil.
Archives of medical research 2002;33(6):581-5.
2002: Leticia F Pettenuzzo; Patrícia F Schuck; Fernanda Urruth Fontella; Clóvis M D Wannmacher; Angela T S Wyse; Carlos Severo Dutra-Filho; Carlos Alexandre Netto; Moacir Wajner
Ascorbic acid prevents cognitive deficits caused by chronic administration of propionic acid to rats in the water maze.
Pharmacology, biochemistry, and behavior 2002;73(3):623-9.
2002: Luciane Rosa Feksa; Andrea Renata Cornelio; Virginia Cielo Rech; Carlos Severo Dutra-Filho; Angela T S Wyse; Moacir Wajner; Clóvis M D Wannmacher
Alanine prevents the reduction of pyruvate kinase activity in brain cortex of rats subjected to chemically induced hyperphenylalaninemia.
Neurochemical research 2002;27(9):947-52.
2002: Virginia Cielo Rech; Luciane Rosa Feksa; Carlos Severo Dutra-Filho; Angela T S Wyse; Moacir Wajner; Clóvis M D Wannmacher
Inhibition of the mitochondrial respiratory chain by alanine in rat cerebral cortex.
Metabolic brain disease 2002;17(3):123-30.
2002: Débora Delwing; Daniela Delwing; Carlos Severo Dutra-Filho; Clóvis M D Wannmacher; Moacir Wajner; Angela T S Wyse
Arginine administration reduces catalase activity in midbrain of rats.
Neuroreport 2002;13(10):1301-4.
2002: Marcos E S Frizzo; Diogo R Lara; Alexandre de Souza Prokopiuk; Carmen R Vargas; Christianne Salbego; Moacir Wajner; Diogo O Souza
Guanosine enhances glutamate uptake in brain cortical slices at normal and excitotoxic conditions.
Cellular and molecular neurobiology 2002;22(3):353-63.
2002: Emilio Streck; Alexandra I Zugno; Bárbara Tagliari; Clóvis M D Wannmacher; Moacir Wajner; Angela T S Wyse
Inhibition of Na+, K+-ATPase activity by the metabolites accumulating in homocystinuria.
Metabolic brain disease 2002;17(2):83-91.
2002: Regina Pessoa Pureur; Cláudia Funchal; Priscila de Lima Pelaez; Lilian Vivian; S Oliveira Loureiro; R de Freitas Miranda; Moacir Wajner
Effect of the branched-chain alpha-ketoacids accumulating in maple syrup urine disease on the high molecular weight neurofilament subunit (NF-H) in rat cerebral cortex.
Metabolic brain disease 2002;17(2):65-75.
2002: Ana M Brusque; Rafael Borba Rosa; Patrícia F Schuck; Karina B Dalcin; César A J Ribeiro; CG Silva; Clóvis M D Wannmacher; Carlos Severo Dutra-Filho; Angela T S Wyse; P Briones; Moacir Wajner
Inhibition of the mitochondrial respiratory chain complex activities in rat cerebral cortex by methylmalonic acid.
Neurochemistry international 2002;40(7):593-601.
2002: Stefan Kölker; Jürgen G Okun; Barbara Ahlemeyer; Angela T S Wyse; Friederike Hörster; Moacir Wajner; Dirk Kohlmüller; Ertan Mayatepek; Josef Krieglstein; Georg F Hoffmann
Chronic treatment with glutaric acid induces partial tolerance to excitotoxicity in neuronal cultures from chick embryo telencephalons.
Journal of neuroscience research 2002;68(4):424-31.
2002: Virginia Cielo Rech; Luciane Rosa Feksa; Carlos Severo Dutra-Filho; Angela T S Wyse; Moacir Wajner; Clóvis M D Wannmacher
Inhibition of the mitochondrial respiratory chain by phenylalanine in rat cerebral cortex.
Neurochemical research 2002;27(5):353-7.
2002: Martine E Kienzle Hagen; Carolina D Pederzolli; Angela M Sgaravatti; Raquel Bridi; Moacir Wajner; Clóvis M D Wannmacher; Angela T S Wyse; Carlos Severo Dutra-Filho
Experimental hyperphenylalaninemia provokes oxidative stress in rat brain.
Biochimica et biophysica acta 2002;1586(3):344-52.
2002: Emilio Streck; Alexandra I Zugno; Bárbara Tagliari; João José Freitas Sarkis; Moacir Wajner; Clóvis M D Wannmacher; Angela T S Wyse
On the mechanism of the inhibition of Na(+), K(+)-ATPase activity caused by homocysteine.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 2002;20(2):77-81.
2002: Fernanda Urruth Fontella; Edson Gassen; Vânia Pulrolnik; Clóvis M D Wannmacher; Adriane B Klein; Moacir Wajner; Carlos Severo Dutra-Filho
Stimulation of lipid peroxidation in vitro in rat brain by the metabolites accumulating in maple syrup urine disease.
Metabolic brain disease 2002;17(1):47-54.
2002: Cleide G da Silva; César A J Ribeiro; Guilhian Leipnitz; Carlos Severo Dutra-Filho; Angela T S Wyse AT; Clóvis M D Wannmacher; João José Freitas Sarkis; Cornelis Jakobs; Moacir Wajner
Inhibition of cytochrome c oxidase activity in rat cerebral cortex and human skeletal muscle by D-2-hydroxyglutaric acid in vitro.
Biochimica et biophysica acta 2002;1586(1):81-91.
2001: Angela T S Wyse; Caren S Bavaresco; M E Hagen; Débora Delwing; Clóvis M D Wannmacher; C Severo Dutra-Filho; Moacir Wajner
In vitro stimulation of oxidative stress in cerebral cortex of rats by the guanidino compounds accumulating in hyperargininemia.
Brain research 2001;923(1-2):50-7.
2001: Z L Pontes; L S Oliveira; Renata Franzon; Moacir Wajner; Clóvis M D Wannmacher; Angela T S Wyse
Inhibition of Na+,K+-ATPase activity from rat hippocampus by proline.
Neurochemical research 2001;26(12):1321-6.
2001: AR Silva; CG Silva; C Ruschel; C Helegda; Angela T S Wyse; Clóvis M D Wannmacher; Moacir Wajner; Carlos Severo Dutra-Filho
L-pyroglutamic acid inhibits energy production and lipid synthesis in cerebral cortex of young rats in vitro.
Neurochemical research 2001;26(12):1277-83.
2001: Ana M Brusque; Liane N Rotta; Rejane G Tavares; Tatiana Emanuelli; Carolina Schwarzbold; Carlos Severo Dutra-Filho; Angela Terezinha de Souza Wyse; Clovis Milton Duval Wannmacher; D O Gomes de Souza; Moacir Wajner
Effects of methylmalonic and propionic acids on glutamate uptake by synaptosomes and synaptic vesicles and on glutamate release by synaptosomes from cerebral cortex of rats.
Brain research 2001;920(1-2):194-201.
2001: Emilio Streck; Alexandra I Zugno; Bárbara Tagliari; Renata Franzon; Clóvis M D Wannmacher; Moacir Wajner; Angela T S Wyse
Inhibition of rat brain Na+, K+-ATPase activity induced by homocysteine is probably mediated by oxidative stress.
Neurochemical research 2001;26(11):1195-200.
2001: Rejane G Tavares; Candice E S Santos; Carla I Tasca; Moacir Wajner; Diogo O Souza; Carlos Severo Dutra-Filho
Inhibition of glutamate uptake into synaptic vesicles from rat brain by 3-nitropropionic acid in vitro.
Experimental neurology 2001;172(1):250-4.
2001: CF de Mello; Stefan Kölker; Barbara Ahlemeyer; F R de Souza; Michele Rechia Fighera; E Mayatepek; J Krieglstein; G F Hoffmann; Moacir Wajner
Intrastriatal administration of 3-hydroxyglutaric acid induces convulsions and striatal lesions in rats.
Brain research 2001;916(1-2):70-5.
2001: M Bedin; C H Estrella; D Ponzi; D V Duarte; Carlos Severo Dutra-Filho; Angela T S Wyse; Moacir Wajner; Clóvis M D Wannmacher
Reduced Na(+), K(+)-ATPase activity in erythrocyte membranes from patients with phenylketonuria.
Pediatric research 2001;50(1):56-60.
2001: Angela T S Wyse; Caren S Bavaresco; C Bandinelli; Emilio Streck; Renata Franzon; Carlos Severo Dutra-Filho; Moacir Wajner
Nitric oxide synthase inhibition by L-NAME prevents the decrease of Na+,K+-ATPase activity in midbrain of rats subjected to arginine administration.
Neurochemical research 2001;26(5):515-20.
2001: AR Silva; C Ruschel; C Helegda; Angela T S Wyse; Clóvis M D Wannmacher; Moacir Wajner; Carlos Severo Dutra-Filho
Inhibition of in vitro CO2 production and lipid synthesis by 2-hydroxybutyric acid in rat brain.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.] 2001;34(5):627-31.
2001: P Araújo; Guillermo F Wassermann; K Tallini; V Furlanetto; Carmen R Vargas; Clóvis M D Wannmacher; Carlos Severo Dutra-Filho; Angela T S Wyse; Moacir Wajner
Reduction of large neutral amino acid levels in plasma and brain of hyperleucinemic rats.
Neurochemistry international 2001;38(6):529-37.
2001: Adriana S Coitinho; CF de Mello; Telmo Tiburcio Fortes Lima; J de Bastiani; Michele Rechia Fighera; Moacir Wajner
Pharmacological evidence that alpha-ketoisovaleric acid induces convulsions through GABAergic and glutamatergic mechanisms in rats.
Brain research 2001;894(1):68-73.
2001: Ana M Brusque; Liane N Rotta; Leticia F Pettenuzzo; Débora Junqueira; Carolina Schwarzbold; Angela T S Wyse; Clóvis M D Wannmacher; Carlos Severo Dutra-Filho; Moacir Wajner
Chronic postnatal administration of methylmalonic acid provokes a decrease of myelin content and ganglioside N-acetylneuraminic acid concentration in cerebrum of young rats.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.] 2001;34(2):227-31.
2000: Rejane G Tavares; Candice E S Santos; Carla I Tasca; Moacir Wajner; Diogo O Souza; Carlos Severo Dutra-Filho
Inhibition of glutamate uptake into synaptic vesicles of rat brain by the metabolites accumulating in maple syrup urine disease.
Journal of the neurological sciences 2000;181(1-2):44-9.
2000: T Branco; R Meirelles; B B da Rocha; A de Mattos-Dutra; Moacir Wajner; Regina Pessoa Pureur
Alpha-ketoisocaproate increases the in vitro 32P incorporation into intermediate filaments in cerebral cortex of rats.
Neuroreport 2000;11(16):3545-50.
2000: Angela T S Wyse; Emilio Streck; Sonja Vergínia Barros; Ana M Brusque; Alexandra I Zugno; Moacir Wajner
Methylmalonate administration decreases Na+,K+-ATPase activity in cerebral cortex of rats.
Neuroreport 2000;11(10):2331-4.
2000: Moacir Wajner; D M Coelho; Alethéa G Barschak; P R Araújo; R F Pires; F L Lulhier; Carmen R Vargas
Reduction of large neutral amino acid concentrations in plasma and CSF of patients with maple syrup urine disease during crises.
Journal of inherited metabolic disease 2000;23(5):505-12.
2000: CG Silva; AR Silva; C Ruschel; C Helegda; Angela T S Wyse; Clóvis M D Wannmacher; Carlos Severo Dutra-Filho; Moacir Wajner
Inhibition of energy production in vitro by glutaric acid in cerebral cortex of young rats.
Metabolic brain disease 2000;15(2):123-31.
2000: M Bedin; C H Estrella; D V Duarte; D Ponzi; Carlos Severo Dutra-Filho; Angela T S Wyse; Moacir Wajner; Clóvis M D Wannmacher
Platelet Na+, K+-ATPase activity as a possible peripheral marker for the neurotoxic effects of phenylalanine in phenylketonuria.
Metabolic brain disease 2000;15(2):115-21.
2000: Fernanda Urruth Fontella; Vânia Pulrolnik; E Gassen; Clóvis M D Wannmacher; A B Klein; Moacir Wajner; Carlos Severo Dutra-Filho
Propionic and L-methylmalonic acids induce oxidative stress in brain of young rats.
Neuroreport 2000;11(3):541-4.
2000: A de Mattos-Dutra; R Meirelles; B Bevilaqua da Rocha; Trícia Kommers; Susana Wofchuk; Moacir Wajner; Regina Pessoa Pureur
Methylmalonic and propionic acids increase the in vitro incorporation of 32P into cytoskeletal proteins from cerebral cortex of young rats through NMDA glutamate receptors.
Brain research 2000;856(1-2):111-8.
2000: Lisiane O Porciúncula; A Dal-Pizzol; Adriana S Coitinho; Tatiana Emanuelli; Diogo O Souza; Moacir Wajner
Inhibition of synaptosomal [3H]glutamate uptake and [3H]glutamate binding to plasma membranes from brain of young rats by glutaric acid in vitro.
Journal of the neurological sciences 2000;173(2):93-6.
2000: Rejane G Tavares; Carla I Tasca; Candice E S Santos; Moacir Wajner; Diogo O Souza; Carlos Severo Dutra-Filho
Quinolinic acid inhibits glutamate uptake into synaptic vesicles from rat brain.
Neuroreport 2000;11(2):249-53.
1999: Z E Pontes; L S Oliveira; C S Baveresco; Emilio Streck; Carlos Severo Dutra-Filho; Moacir Wajner; Clóvis M D Wannmacher; Angela T S Wyse
Proline administration decreases Na+,K+-ATPase activity in the synaptic plasma membrane from cerebral cortex of rats.
Metabolic brain disease 1999;14(4):265-72.
1999: Ana M Brusque; Carlos Fernando Mello; D N Buchanan; S T Terracciano; M P Rocha; Carmen R Vargas; Clóvis M D Wannmacher; Moacir Wajner
Effect of chemically induced propionic acidemia on neurobehavioral development of rats.
Pharmacology, biochemistry, and behavior 1999;64(3):529-34.
1999: AR Silva; C Ruschel; C Helegda; Ana M Brusque; Clóvis M D Wannmacher; Moacir Wajner; C S Dustra-Filho
Inhibition of rat brain lipid synthesis in vitro by 4-hydroxybutyric acid.
Metabolic brain disease 1999;14(3):157-64.
1999: Cleide G da Silva; E Parolo; Emilio Streck; Moacir Wajner; Clóvis M D Wannmacher; Angela T S Wyse
In vitro inhibition of Na+,K(+)-ATPase activity from rat cerebral cortex by guanidino compounds accumulating in hyperargininemia.
Brain research 1999;838(1-2):78-84.
1999: Michele Rechia Fighera; Claudio Queiroz; M P Stracke; M C Brauer; L L González-Rodríguez; Roberto Frussa-Filho; Moacir Wajner; CF de Mello
Ascorbic acid and alpha-tocopherol attenuate methylmalonic acid-induced convulsions.
Neuroreport 1999;10(10):2039-43.
1999: Moacir Wajner; C R Vargas
Reduction of plasma concentrations of large neutral amino acids in patients with maple syrup urine disease during crises.
Archives of disease in childhood 1999;80(6):579.
1999: Angela T S Wyse; M E Noriler; L F Borges; P J Floriano; CG Silva; Moacir Wajner; Clóvis M D Wannmacher
Alanine prevents the decrease of Na+,K+-ATPase activity in experimental phenylketonuria.
Metabolic brain disease 1999;14(2):95-101.
1999: Carlos Fernando Mello; L Feksa; Ana M Brusque; Clóvis M D Wannmacher; Moacir Wajner
Chronic early leucine administration induces behavioral deficits in rats.
Life sciences 1999;65(8):747-55.
1999: Moacir Wajner; K D Santos; J L Schlottfeldt; M P Rocha; Clóvis M D Wannmacher
Inhibition of mitogen-activated proliferation of human peripheral lymphocytes in vitro by propionic acid.
Clinical science (London, England : 1979) 1999;96(1):99-103.
1998: A de Mattos-Dutra; M Sampaio de Freitas; Moacir Wajner; Regina Pessoa Pureur
Propionic and methylmalonic acids inhibit the in vitro phosphorylation of a 85 kDa cytoskeletal protein from cerebral cortex of rats.
Neurochemistry international 1998;33(5):407-14.
1998: Telmo Tiburcio Fortes Lima; J Begnini; J de Bastiani; D B Fialho; A Jurach; Marinei Cristina Pereira Ribeiro; Moacir Wajner; CF de Mello
Pharmacological evidence for GABAergic and glutamatergic involvement in the convulsant and behavioral effects of glutaric acid.
Brain research 1998;802(1-2):55-60.
1998: A de Mattos-Dutra; MS de Freitas; C S Lisboa; Regina Pessoa Pureur; Moacir Wajner
Effects of acute and chronic administration of methylmalonic and propionic acids on the in vitro incorporation of 32P into cytoskeletal proteins from cerebral cortex of young rats.
Neurochemistry international 1998;33(1):75-82.
1998: Ana M Brusque; S T Terracciano; F U Fontella; C Vargas; Cleide G da Silva; Angela T S Wyse; Vera M T Trindade; Clóvis M D Wannmacher; Moacir Wajner
Chronic administration of propionic acid reduces ganglioside N-acetylneuraminic acid concentration in cerebellum of young rats.
Journal of the neurological sciences 1998;158(2):121-4.
1998: Angela T S Wyse; Ana M Brusque; CG Silva; Emilio Streck; Moacir Wajner; Clóvis M D Wannmacher
Inhibition of Na+,K+-ATPase from rat brain cortex by propionic acid.
Neuroreport 1998;9(8):1719-21.
1997: A de Mattos-Dutra; M Sampaio de Freitas; Nadja Schröder; C S Fogaça Lisboa; Regina Pessoa Pureur; Moacir Wajner
In vitro phosphorylation of cytoskeletal proteins in the rat cerebral cortex is decreased by propionic acid.
Experimental neurology 1997;147(2):238-47.
1997: CF de Mello; Maribel Antonello Rubin; J Coelho; Moacir Wajner; Diogo O Souza
Effects of methylmalonate and propionate on [3H]glutamate binding, adenylate cyclase activity and lipid synthesis in rat cerebral cortex.
Biochemistry and molecular biology international 1997;42(6):1143-50.
1997: Janice C Coelho; Moacir Wajner; Maira G Burin; C R Vargas; Roberto Giugliani
Selective screening of 10,000 high-risk Brazilian patients for the detection of inborn errors of metabolism.
European journal of pediatrics 1997;156(8):650-4.
1997: A de Mattos-Dutra; MS de Freitas; Nadja Schröder; A C Zilles; Moacir Wajner; Regina Pessoa Pureur
Methylmalonic acid reduces the in vitro phosphorylation of cytoskeletal proteins in the cerebral cortex of rats.
Brain research 1997;763(2):221-31.
1996: K D Santos; M Rocha; Clóvis M D Wannmacher; Moacir Wajner
The influence of organic acids on the proliferation of human peripheral lymphocytes activated by concanavalin A and pokeweed mitogen.
International journal of immunopharmacology 1996;18(12):761-9.
1996: CF de Mello; J Begnini; R E Jiménez-Bernal; Maribel Antonello Rubin; J de Bastiani; E da Costa; Moacir Wajner
Intrastriatal methylmalonic acid administration induces rotational behavior and convulsions through glutamatergic mechanisms.
Brain research 1996;721(1-2):120-5.
1995: K Ckless; J L Schlottfeldt; M Pasqual; P Moyna; J A Henriques; Moacir Wajner
Inhibition of in-vitro lymphocyte transformation by the isoquinoline alkaloid berberine.
The Journal of pharmacy and pharmacology 1995;47(12A):1029-31.
1995: CF de Mello; D D De La Vega; L T Pizutti; F P Lopes; Maribel Antonello Rubin; J G Homerich; C R Melo; J E Somer; D O Souza; Moacir Wajner
Neurochemical effects of L-pyroglutamic acid.
Neurochemical research 1995;20(12):1437-41.
1995: Angela T S Wyse; João José Freitas Sarkis; J S Cunha-Filho; M V Teixeira; Maria R C Schetinger; Moacir Wajner; Clóvis M D Wannmacher
ATP diphosphohydrolase activity in synaptosomes from cerebral cortex of rats subjected to chemically induced phenylketonuria.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.] 1995;28(6):643-9.
1995: C S Dutra-Filho; Moacir Wajner; Clóvis M D Wannmacher; E Gassen; Rafael Henriques Candiago; A M Wilhelms; H F de Malfussi
Inhibition of citrate oxidation in vitro by 2-hydroxybutyrate and 4-hydroxybutyrate in cerebral cortex of young rats.
Biochemical Society transactions 1995;23(2):229S.
1995: C S Dutra-Filho; Moacir Wajner; Clóvis M D Wannmacher; E Gassen; Rafael Henriques Candiago; A M Wilhelms; H F de Malfussi
2-Hydroxybutyrate and 4-hydroxybutyrate inhibit CO2 formation from labeled substrates by rat cerebral cortex.
Biochemical Society transactions 1995;23(2):228S.
1995: Angela T S Wyse; Moacir Wajner; Ana M Brusque; Clóvis M D Wannmacher
Alanine reverses the inhibitory effect of phenylalanine and its metabolites on Na+,K(+)-ATPase in synaptic plasma membranes from cerebral cortex of rats.
Biochemical Society transactions 1995;23(2):227S.
1995: J Schlottfeldt; L R Blazina; Clóvis M D Wannmacher; Moacir Wajner
The effect of organic acids on phytohaemagglutinin-activated proliferation of human lymphocytes in vitro.
International journal of immunopharmacology 1995;17(3):175-82.
1995: Moacir Wajner; J L Schlottfeldt; K Ckless; Clóvis M D Wannmacher
Immunosuppressive effects of organic acids accumulating in patients with maple syrup urine disease.
Journal of inherited metabolic disease 1995;18(2):165-8.
1994: M H Sommer; M H Xavier; M B Fialho; Clóvis M D Wannmacher; Moacir Wajner
The influence of amino acids on mitogen-activated proliferation of human lymphocytes in vitro.
International journal of immunopharmacology 1994;16(10):865-72.
1994: Angela T S Wyse; João José Freitas Sarkis; J S Cunha-Filho; M V Teixeira; Maria R C Schetinger; Moacir Wajner; C Milton; D Wannmacher
Effect of phenylalanine and its metabolites on ATP diphosphohydrolase activity in synaptosomes from rat cerebral cortex.
Neurochemical research 1994;19(9):1175-80.
1994: Carlos Fernando Mello; J E Somer; V Tavaroni; R Graciolli; V Wu; G Torres; F Aguiar; Moacir Wajner; Clóvis M D Wannmacher
Effects of postnatal methylmalonate administration on neurobehavioral development of rats.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.] 1994;27(3):655-61.
1993: J C Dutra; C S Dutra-Filho; S E Cardozo; Clóvis M D Wannmacher; João José Freitas Sarkis; Moacir Wajner
Inhibition of succinate dehydrogenase and beta-hydroxybutyrate dehydrogenase activities by methylmalonate in brain and liver of developing rats.
Journal of inherited metabolic disease 1993;16(1):147-53.
1992: M H Sommer; M H Xavier; M B Fialho; Clóvis M D Wannmacher; A M Medeiros; Moacir Wajner
Immunomodulatory action of amino acids on lymphocyte blastogenesis.
Biochemical Society transactions 1992;20(2):176S.
1992: Moacir Wajner; M T Sanseverino; Roberto Giugliani; L Sweetman; S Yamaguchi; T Fukao; V E Shih
Biochemical investigation of a Brazilian patient with a defect in mitochondrial acetoacetylcoenzyme-A thiolase.
Clinical genetics 1992;41(4):202-5.
1992: Moacir Wajner; J C Dutra; S E Cardoso; Clóvis M D Wannmacher; E R Motta
Effect of methylmalonate on in vitro lactate release and carbon dioxide production by brain of suckling rats.
Journal of inherited metabolic disease 1992;15(1):92-6.
1991: J C Dutra; Moacir Wajner; C F Wannmacher; C S Dutra-Filho; Clóvis M D Wannmacher
Effects of methylmalonate and propionate on uptake of glucose and ketone bodies in vitro by brain of developing rats.
Biochemical medicine and metabolic biology 1991;45(1):56-64.
1991: J C Dutra; Moacir Wajner; Clóvis M D Wannmacher; L E Wannmacher; Ricardo F Pires; A Rosa-Júnior
Effect of postnatal methylmalonate administration on adult rat behavior.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.] 1991;24(6):595-605.
1991: Roberto Giugliani; J C Dutra; M L Barth; C S Dutra-Filho; S L Goldenfum; Moacir Wajner
Seven-year experience of a reference laboratory for detection of inborn errors of metabolism in Brazil.
Journal of inherited metabolic disease 1991;14(3):400-2.
1990: Moacir Wajner; Clóvis M D Wannmacher; P Purkiss
High urinary excretion of N-(pyrrole-2-carboxyl) glycine in type II hyperprolinemia.
Clinical genetics 1990;37(6):485-9.
1990: J C Dutra; Moacir Wajner; C S Dutra-Filho; C F Mannmacher; Clóvis M D Wannmacher
Influence of methylmalonate on the uptake of ketone bodies in vitro by the brain of young rats.
Biochemical Society transactions 1990;18(3):421-2.
1990: N R Rodrigues; Clóvis M D Wannmacher; C S Dutra-Filho; Ricardo F Pires; P R Fagan; Moacir Wajner
Effect of phenylalanine, p-chlorophenylalanine and alpha-methylphenylalanine on glucose uptake in vitro by the brain of young rats.
Biochemical Society transactions 1990;18(3):419.
1989: Roberto Giugliani; C S Dutra-Filho; M L Barth; J C Dutra; Moacir Wajner; Clóvis M D Wannmacher; L T Montagner
Inborn errors of metabolism. Sensitivity of screening tests in high risk patients.
Clinical pediatrics 1989;28(11):494-7.
1989: C S Dutra-Filho; Clóvis M D Wannmacher; Ricardo F Pires; G Gus; A M Kalil; Moacir Wajner
Reduced locomotor activity of rats made histidinemic by injection of histidine.
The Journal of nutrition 1989;119(8):1223-7.
1989: J C Moreira; Clóvis M D Wannmacher; S M Costa; Moacir Wajner
Effect of proline administration on rat behavior in aversive and nonaversive tasks.
Pharmacology, biochemistry, and behavior 1989;32(4):885-90.
1988: Moacir Wajner; E C Brites; J C Dutra; M S Buchalter; A H Pons; Ricardo F Pires; L E Wannmacher; A Rosa Júnior; Vera M T Trindade; Clóvis M D Wannmacher
Diminished concentrations of ganglioside N-acetylneuraminic acid (G-NeuAc) in cerebellum of young rats receiving chronic administration of methylmalonic acid.
Journal of the neurological sciences 1988;85(2):233-8.
1987: Clóvis M D Wannmacher; Moacir Wajner; M S Buchalter; C S Dutra-Filho; V B Pellini; D L Pedroso; F S Branco; MARCELO ZUBARAN GOLDANI; A R Bolner
Detection of inborn errors of metabolism in unselected patients from pediatric intensive care units in Porto Alegre, Brazil: evaluation of screening techniques.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.] 1987;20(1):11-23.
1987: Moacir Wajner; S S Papiha; T I Wagstaff
Relationship between serum immunoglobulin G and alpha-fetoprotein levels during human pregnancy.
Journal of perinatal medicine 1987;15(3):251-7.
1986: Moacir Wajner; S S Papiha; T I Wagstaff
Inhibition of mitogen and allogeneic stimulated lymphocyte growth by human amniotic fluid: lack of correlation between alpha-fetoprotein level and in vitro immunosuppression.
European journal of obstetrics, gynecology, and reproductive biology 1986;21(4):225-32.
1984: Clóvis M D Wannmacher; Moacir Wajner; R Giugliani; M G Costa; E R Giugliani; J Z Castro
Clinical and biochemical effects of long-term vitamin A administration to a patient with Hurler-Scheie compound.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.] 1984;17(1):43-7.
1984: M S Buchalter; Clóvis M D Wannmacher; Moacir Wajner
Tay-Sachs disease heterozygote detection in Brazil: comparison between tears and leukocytes as beta-hexosaminidase A source.
Journal of inherited metabolic disease 1984;7(1):35-7.
1983: Moacir Wajner; S S Papiha; T I Wagstaff
Response of human peripheral blood lymphocytes in the presence of cord sera: relationship of lymphocyte transformation with number of pregnancies and levels of alpha-fetoprotein.
Clinical and experimental immunology 1983;52(2):381-6.
1983: S S Papiha; Moacir Wajner; T I Wagstaff
Inhibition of lymphocyte transformation by serum from pregnant women: lack of correlation with levels of alpha-fetoprotein.
Biology of the neonate 1983;43(3-4):109-17.