Keiji Wakabayashi

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Mutoh Michihiro; Komiya Masami; Teraoka Naoya; Ueno Toshiya; Takahashi Mami; Kitahashi Tsukasa; Sugimura Takashi; Wakabayashi Keiji
Overexpression of low-density lipoprotein receptor and lipid accumulation in intestinal polyps in Min mice.
Yamamoto Masafumi; Nakano Tsuyoshi; Matsushima-Hibiya Yuko; Totsuka Yukari; Takahashi-Nakaguchi Azusa; Matsumoto Yasuko; Sugimura Takashi; Wakabayashi Keiji
Molecular cloning of apoptosis-inducing Pierisin-like proteins, from two species of white butterfly, Pieris melete and Aporia crataegi.
Nishigaki Rena; Watanabe Tetsushi; Kajimoto Tetsuya; Tada Atsuko; Takamura-Enya Takeji; Enomoto Shigeki; Nukaya Haruo; Terao Yoshiyasu; Muroyama Atsushi; Ozeki Minoru; Node Manabu; Hasei Tomohiro; Totsuka Yukari; Wakabayashi Keiji
Isolation and identification of a novel aromatic amine mutagen produced by the Maillard reaction.

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All Publications

2009: Mutoh Michihiro; Komiya Masami; Teraoka Naoya; Ueno Toshiya; Takahashi Mami; Kitahashi Tsukasa; Sugimura Takashi; Wakabayashi Keiji
Overexpression of low-density lipoprotein receptor and lipid accumulation in intestinal polyps in Min mice.
International journal of cancer. Journal international du cancer 2009;125(11):2505-10.
2009: Yamamoto Masafumi; Nakano Tsuyoshi; Matsushima-Hibiya Yuko; Totsuka Yukari; Takahashi-Nakaguchi Azusa; Matsumoto Yasuko; Sugimura Takashi; Wakabayashi Keiji
Molecular cloning of apoptosis-inducing Pierisin-like proteins, from two species of white butterfly, Pieris melete and Aporia crataegi.
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 2009;154(3):326-33.
2009: Nishigaki Rena; Watanabe Tetsushi; Kajimoto Tetsuya; Tada Atsuko; Takamura-Enya Takeji; Enomoto Shigeki; Nukaya Haruo; Terao Yoshiyasu; Muroyama Atsushi; Ozeki Minoru; Node Manabu; Hasei Tomohiro; Totsuka Yukari; Wakabayashi Keiji
Isolation and identification of a novel aromatic amine mutagen produced by the Maillard reaction.
Chemical research in toxicology 2009;22(9):1588-93.
2009: Takasuka Nobuo; Takahashi Mami; Hori Yusaku; Kitahashi Tsukasa; Iigo Masaaki; Imai Toshio; Yoshimi Naoki; Sugimura Takashi; Wakabayashi Keiji
Promotion of mouse two-stage skin carcinogenesis by diacylglycerol-rich edible oil.
Cancer letters 2009;275(1):150-7.
2009: Totsuka Yukari; Higuchi Takashi; Imai Toshio; Nishikawa Akiyoshi; Nohmi Takehiko; Kato Tatsuya; Masuda Shuich; Kinae Naohide; Hiyoshi Kyoko; Ogo Sayaka; Kawanishi Masanobu; Yagi Takashi; Ichinose Takamichi; Fukumori Nobutaka; Watanabe Masatoshi; Sugimura Takashi; Wakabayashi Keiji
Genotoxicity of nano/microparticles in in vitro micronuclei, in vivo comet and mutation assay systems.
Particle and fibre toxicology 2009;6():23.
2008: Deguchi Yuya; Wu Nan Xiang; Toyoizumi Tomoyasu; Masuda Shuichi; Nagaoka Hiroaki; Watanabe Tetsushi; Totsuka Yukari; Wakabayashi Keiji; Kinae Naohide
Application of a new bioassay technique using goldfish for assessment of water toxicity.
Environmental toxicology 2008;23(6):720-7.
2008: Hori Yusaku; Takasuka Nobuo; Mutoh Michihiro; Kitahashi Tsukasa; Kojima Shuji; Imaida Katsumi; Suzuki Masahiro; Kohara Kazushi; Yamamoto Shuji; Moriyama Noriyuki; Sugimura Takashi; Wakabayashi Keiji
Periodic analysis of urethane-induced pulmonary tumors in living A/J mice by respiration-gated X-ray microcomputed tomography.
Cancer science 2008;99(9):1774-7.
2008: Terasaki Masaru; Totsuka Yukari; Nishimura Koichi; Mukaisho Ken-Ichi; Chen Kuan-Hao; Hattori Takanori; Takamura-Enya Takeji; Sugimura Takashi; Wakabayashi Keiji
Detection of endogenous DNA adducts, O-carboxymethyl-2'-deoxyguanosine and 3-ethanesulfonic acid-2'-deoxycytidine, in the rat stomach after duodenal reflux.
Cancer science 2008;99(9):1741-6.
2008: Takahashi Mami; Kitahashi Tsukasa; Ishigamori Rikako; Mutoh Michihiro; Komiya Masami; Sato Hidetaka; Kamanaka Yoshihisa; Naka Masao; Maruyama Takayuki; Sugimura Takashi; Wakabayashi Keiji
Increased expression of inducible nitric oxide synthase (iNOS) in N-nitrosobis(2-oxopropyl)amine-induced hamster pancreatic carcinogenesis and prevention of cancer development by ONO-1714, an iNOS inhibitor.
Carcinogenesis 2008;29(8):1608-13.
2008: Mutoh Michihiro; Niho Naoko; Komiya Masami; Takahashi Mami; Ohtsubo Rina; Nakatogawa Kiyoshi; Ueda Kentaro; Sugimura Takashi; Wakabayashi Keiji
Plasminogen activator inhibitor-1 (Pai-1) blockers suppress intestinal polyp formation in Min mice.
Carcinogenesis 2008;29(4):824-9.
2008: Kitahashi Tsukasa; Takahashi Mami; Yamada Yutaka; Oghiso Yoichi; Yokohira Masanao; Imaida Katsumi; Tsutsumi Masahiro; Takasuka Nobuo; Sugimura Takashi; Wakabayashi Keiji
Occurrence of mutations in the epidermal growth factor receptor gene in X-ray-induced rat lung tumors.
Cancer science 2008;99(2):241-5.
2008: Matsumoto Yasuko; Nakano Tsuyoshi; Yamamoto Masafumi; Matsushima-Hibiya Yuko; Odagiri Ken-Ichi; Yata Osamu; Koyama Kotaro; Sugimura Takashi; Wakabayashi Keiji
Distribution of cytotoxic and DNA ADP-ribosylating activity in crude extracts from butterflies among the family Pieridae.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(7):2516-20.
2008: Watanabe Tetsushi; Takahashi Kazuhiko; Konishi Erina; Hoshino Yuri; Hasei Tomohiro; Asanoma Masaharu; Hirayama Teruhisa; Wakabayashi Keiji
Mutagenicity of surface soil from residential areas in Kyoto city, Japan, and identification of major mutagens.
Mutation research 2008;649(1-2):201-12.
2007: Kohno Hiroyuki; Totsuka Yukari; Yasui Yumiko; Suzuki Rikako; Sugie Shigeyuki; Wakabayashi Keiji; Tanaka Takuji
Tumor-initiating potency of a novel heterocyclic amine, aminophenylnorharman in mouse colonic carcinogenesis model.
International journal of cancer. Journal international du cancer 2007;121(8):1659-64.
2007: Niho Naoko; Mutoh Michihiro; Komiya Masami; Ohta Tsutomu; Sugimura Takashi; Wakabayashi Keiji
Improvement of hyperlipidemia by indomethacin in Min mice.
International journal of cancer. Journal international du cancer 2007;121(8):1665-9.
2007: Sakano Katsuhisa; Takahashi Mami; Mutoh Michihiro; Niho Naoko; Komiya Masami; Sato Hidetaka; Tanaka Takuji; Sugimura Takashi; Wakabayashi Keiji
Enhanced thyroid carcinogenicity of N-nitrosobis(2-oxopropyl)amine in Otsuka Long-Evans Tokushima Fatty rats, a model of type II diabetes mellitus.
Carcinogenesis 2007;28(10):2193-8.
2007: Takeuchi Yoshito; Takahashi Mami; Sakano Katsuhisa; Mutoh Michihiro; Niho Naoko; Yamamoto Masafumi; Sato Hidetaka; Sugimura Takashi; Wakabayashi Keiji
Suppression of N-nitrosobis(2-oxopropyl)amine-induced pancreatic carcinogenesis in hamsters by pioglitazone, a ligand of peroxisome proliferator-activated receptor gamma.
Carcinogenesis 2007;28(8):1692-6.
2007: Kohno Hiroyuki; Takahashi Mami; Yasui Yumiko; Suzuki Rikako; Miyamoto Shingo; Kamanaka Yoshihisa; Naka Masao; Maruyama Takayuki; Wakabayashi Keiji; Tanaka Takuji
A specific inducible nitric oxide synthase inhibitor, ONO-1714 attenuates inflammation-related large bowel carcinogenesis in male Apc(Min/+) mice.
International journal of cancer. Journal international du cancer 2007;121(3):506-13.
2007: Kohno Hiroyuki; Suzuki Rikako; Yasui Yumiko; Miyamoto Shingo; Wakabayashi Keiji; Tanaka Takuji
Ursodeoxycholic acid versus sulfasalazine in colitis-related colon carcinogenesis in mice.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(8):2519-25.
2007: Kawanishi Masanobu; Matsukawa Kazuki; Kuraoka Isao; Takamura-Enya Takeji; Totsuka Yukari; Matsumoto Yasuko; Watanabe Masahiko; Zou Yue; Tanaka Kiyoji; Sugimura Takashi; Wakabayashi Keiji; Yagi Takashi
Molecular evidence of the involvement of the nucleotide excision repair (NER) system in the repair of the mono(ADP-ribosyl)ated DNA adduct produced by pierisin-1, an apoptosis-inducing protein from the cabbage butterfly.
Chemical research in toxicology 2007;20(4):694-700.
2007: Nishigaki Rena; Totsuka Yukari; Kataoka Hiroyuki; Ushiyama Hirohumi; Goto Sumio; Akasu Takayuki; Watanabe Tetsushi; Sugimura Takashi; Wakabayashi Keiji
Detection of aminophenylnorharman, a possible endogenous mutagenic and carcinogenic compound, in human urine samples.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2007;16(1):151-6.
2006: Sakano Katsuhisa; Takahashi Mami; Kitano Mitsuaki; Sugimura Takashi; Wakabayashi Keiji
Suppression of azoxymethane-induced colonic premalignant lesion formation by coenzyme Q10 in rats.
Asian Pacific journal of cancer prevention : APJCP 2006;7(4):599-603.
2006: Niho Naoko; Kitamura Tomohiro; Takahashi Mami; Mutoh Michihiro; Sato Hidetaka; Matsuura Mamoru; Sugimura Takashi; Wakabayashi Keiji
Suppression of azoxymethane-induced colon cancer development in rats by a cyclooxygenase-1 selective inhibitor, mofezolac.
Cancer science 2006;97(10):1011-4.
2006: Watanabe Tetsushi; Ohba Hiroshi; Asanoma Masaharu; Hasei Tomohiro; Takamura Takeji; Terao Yoshiyasu; Shiozawa Tatsushi; Hirayama Teruhisa; Wakabayashi Keiji; Nukaya Haruo
Isolation and identification of non-chlorinated phenylbenzotriazole (non-ClPBTA)-type mutagens in the Ho River in Shizuoka Prefecture, Japan.
Mutation research 2006;609(2):137-45.
2006: Nakano Tsuyoshi; Matsushima-Hibiya Yuko; Yamamoto Masafumi; Enomoto Shigeki; Matsumoto Yasuko; Totsuka Yukari; Watanabe Masahiko; Sugimura Takashi; Wakabayashi Keiji
Purification and molecular cloning of a DNA ADP-ribosylating protein, CARP-1, from the edible clam Meretrix lamarckii.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(37):13652-7.
2006: Takamura-Enya Takeji; Enomoto Shigeki; Wakabayashi Keiji
Palladium-catalyzed direct N-arylation of nucleosides, nucleotides, and oligonucleotides for efficient preparation of dG-N2 adducts with carcinogenic amino-/nitroarenes.
The Journal of organic chemistry 2006;71(15):5599-606.
2006: Takamura-Enya Takeji; Ishikawa Satoko; Mochizuki Masataka; Wakabayashi Keiji
Chemical synthesis of 2'-deoxyguanosine-C8 adducts with heterocyclic amines: an application to synthesis of oligonucleotides site-specifically adducted with 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine.
Chemical research in toxicology 2006;19(6):770-8.
2006: Niho Naoko; Mutoh Michihiro; Sakano Katsuhisa; Takahashi Mami; Hirano Sachiko; Nukaya Haruo; Sugimura Takashi; Wakabayashi Keiji
Inhibition of intestinal carcinogenesis by a new flavone derivative, chafuroside, in oolong tea.
Cancer science 2006;97(4):248-51.
2006: Mutoh Michihiro; Niho Naoko; Wakabayashi Keiji
Concomitant suppression of hyperlipidemia and intestinal polyp formation by increasing lipoprotein lipase activity in Apc-deficient mice.
Biological chemistry 2006;387(4):381-5.
2006: Mutoh Michihiro; Akasu Takayuki; Takahashi Mami; Niho Naoko; Yoshida Teruhiko; Sugimura Takashi; Wakabayashi Keiji
Possible involvement of hyperlipidemia in increasing risk of colorectal tumor development in human familial adenomatous polyposis.
Japanese journal of clinical oncology 2006;36(3):166-71.
2006: Suzuki Rikako; Kohno Hiroyuki; Suzui Masumi; Yoshimi Naoki; Tsuda Hiroyuki; Wakabayashi Keiji; Tanaka Takuji
An animal model for the rapid induction of tongue neoplasms in human c-Ha-ras proto-oncogene transgenic rats by 4-nitroquinoline 1-oxide: its potential use for preclinical chemoprevention studies.
Carcinogenesis 2006;27(3):619-30.
2006: Takahashi Mami; Mutoh Michihiro; Shoji Yutaka; Sato Hidetaka; Kamanaka Yoshihisa; Naka Masao; Maruyama Takayuki; Sugimura Takashi; Wakabayashi Keiji
Suppressive effect of an inducible nitric oxide inhibitor, ONO-1714, on AOM-induced rat colon carcinogenesis.
Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society 2006;14(2):130-6.
2006: Shiotani Bunsyo; Kobayashi Masahiko; Watanabe Masahiko; Yamamoto Ken-Ichi; Sugimura Takashi; Wakabayashi Keiji
Involvement of the ATR- and ATM-dependent checkpoint responses in cell cycle arrest evoked by pierisin-1.
Molecular cancer research : MCR 2006;4(2):125-33.
2006: Tanaka Takuji; Kohno Hiroyuki; Suzuki Rikako; Hata Kazuya; Sugie Shigeyuki; Niho Naoko; Sakano Katsuhisa; Takahashi Mami; Wakabayashi Keiji
Dextran sodium sulfate strongly promotes colorectal carcinogenesis in Apc(Min/+) mice: inflammatory stimuli by dextran sodium sulfate results in development of multiple colonic neoplasms.
International journal of cancer. Journal international du cancer 2006;118(1):25-34.
2006: Mutoh Michihiro; Takahashi Mami; Wakabayashi Keiji
Roles of prostanoids in colon carcinogenesis and their potential targeting for cancer chemoprevention.
Current pharmaceutical design 2006;12(19):2375-82.
2005: Shoji Yutaka; Takahashi Mami; Takasuka Nobuo; Niho Naoko; Kitamura Tomohiro; Sato Hidetaka; Maruyama Takayuki; Sugimoto Yukihiko; Narumiya Shuh; Sugimura Takashi; Wakabayashi Keiji
Prostaglandin E receptor EP3 deficiency modifies tumor outcome in mouse two-stage skin carcinogenesis.
Carcinogenesis 2005;26(12):2116-22.
2005: Takamura-Enya Takeji; Mano Nariyasu; Kawahara Nobuo; Goto Junichi; Wakabayashi Keiji
Formation of DNA adducts with cholyl adenylate, a putative intermediate for biosynthesis of cholyl-CoA.
Chemical research in toxicology 2005;18(11):1715-20.
2005: Totsuka Yukari; Nishigaki Rena; Enomoto Shigeki; Takamura-Enya Takeji; Masumura Ken-ichi; Nohmi Takehiko; Kawahara Nobuo; Sugimura Takashi; Wakabayashi Keiji
Structures and biological properties of DNA adducts derived from N-nitroso bile acid conjugates.
Chemical research in toxicology 2005;18(10):1553-62.
2005: Niho Naoko; Mutoh Michihiro; Kitamura Tomohiro; Takahashi Mami; Sato Hidetaka; Yamamoto Hiroshi; Maruyama Takayuki; Ohuchida Shuichi; Sugimura Takashi; Wakabayashi Keiji
Suppression of azoxymethane-induced colon cancer development in rats by a prostaglandin E receptor EP1-selective antagonist.
Cancer science 2005;96(5):260-4.
2005: Shiotani Bunsyo; Watanabe Masahiko; Totsuka Yukari; Sugimura Takashi; Wakabayashi Keiji
Involvement of nucleotide excision repair (NER) system in repair of mono ADP-ribosylated dG adducts produced by pierisin-1, a cytotoxic protein from cabbage butterfly.
Mutation research 2005;572(1-2):150-5.
2005: Watanabe Tetsushi; Hasei Tomohiro; Takahashi Tomoyuki; Asanoma Masaharu; Murahashi Tsuyoshi; Hirayama Teruhisa; Wakabayashi Keiji
Detection of a novel mutagen, 3,6-dinitrobenzo[e]pyrene, as a major contaminant in surface soil in Osaka and Aichi Prefectures, Japan.
Chemical research in toxicology 2005;18(2):283-9.
2005: Niho Naoko; Mutoh Michihiro; Takahashi Mami; Tsutsumi Kazuhiko; Sugimura Takashi; Wakabayashi Keiji
Concurrent suppression of hyperlipidemia and intestinal polyp formation by NO-1886, increasing lipoprotein lipase activity in Min mice.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(8):2970-4.
2005: Kawamori Toshihiko; Kitamura Tomohiro; Watanabe Kouji; Uchiya Naoaki; Maruyama Takayuki; Narumiya Shuh; Sugimura Takashi; Wakabayashi Keiji
Prostaglandin E receptor subtype EP(1) deficiency inhibits colon cancer development.
Carcinogenesis 2005;26(2):353-7.
2004: Kawanishi Masanobu; Takamura-Enya Takeji; Ermawati Rahyani; Shimohara Chiaki; Sakamoto Michiyo; Matsukawa Kazuki; Matsuda Tomonari; Murahashi Tsuyoshi; Matsui Saburo; Wakabayashi Keiji; Watanabe Tetsushi; Tashiro H Yutaka; Yagi Takashi
Detection of genistein as an estrogenic contaminant of river water in Osaka.
Environmental science & technology 2004;38(23):6424-9.
2004: Ohe Takeshi; Watanabe Tetsushi; Wakabayashi Keiji
Mutagens in surface waters: a review.
Mutation research 2004;567(2-3):109-49.
2004: Watanabe Masahiko; Nakano Tsuyoshi; Shiotani Bunsyo; Matsushima-Hibiya Yuko; Kiuchi Makoto; Yukuhiro Fumiko; Kanazawa Takashi; Koyama Kotaro; Sugimura Takashi; Wakabayashi Keiji
Developmental stage-specific expression and tissue distribution of pierisin-1, a guanine-specific ADP-ribosylating toxin, in Pieris rapae.
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 2004;139(2):125-31.
2004: Matsubara Satoshi; Shibata Hideyuki; Takahashi Mami; Ishikawa Fumiyasu; Yokokura Teruo; Sugimura Takashi; Wakabayashi Keiji
Cloning of Mongolian gerbil cDNAs encoding inflammatory proteins, and their expression in glandular stomach during H. pylori infection.
Cancer science 2004;95(10):798-802.
2004: Takamura-Enya Takeji; Watanabe Masahiko; Koyama Kotaro; Sugimura Takashi; Wakabayashi Keiji
Mono(ADP-ribosyl)ation of the N2 amino groups of guanine residues in DNA by pierisin-2, from the cabbage butterfly, Pieris brassicae.
Biochemical and biophysical research communications 2004;323(2):579-82.
2004: Kawamori Toshihiko; Totsuka Yukari; Uchiya Naoaki; Kitamura Tomohiro; Shibata Hideyuki; Sugimura Takashi; Wakabayashi Keiji
Carcinogenicity of aminophenylnorharman, a possible novel endogenous mutagen, formed from norharman and aniline, in F344 rats.
Carcinogenesis 2004;25(10):1967-72.
2004: Nishigaki Rena; Totsuka Yukari; Takamura-Enya Takeji; Sugimura Takashi; Wakabayashi Keiji
Identification of cytochrome P-450s involved in the formation of APNH from norharman with aniline.
Mutation research 2004;562(1-2):19-25.
2004: Shoji Y; Takahashi M; Kitamura T; Watanabe K; Kawamori T; Maruyama T; Sugimoto Y; Negishi M; Narumiya S; Sugimura T; Wakabayashi K
Downregulation of prostaglandin E receptor subtype EP3 during colon cancer development.
Gut 2004;53(8):1151-8.
2004: Takahashi Mami; Wakabayashi Keiji
Gene mutations and altered gene expression in azoxymethane-induced colon carcinogenesis in rodents.
Cancer science 2004;95(6):475-80.
2004: Masuda Shuichi; Deguchi Yuya; Masuda Yumi; Watanabe Tetsushi; Nukaya Haruo; Terao Yoshiyasu; Takamura Takeji; Wakabayashi Keiji; Kinae Naohide
Genotoxicity of 2-[2-(acetylamino)-4-[bis(2-hydroxyethyl)amino]-5-methoxyphenyl]-5-amino-7-bromo-4-chloro-2H-benzotriazole (PBTA-6) and 4-amino-3,3'-dichloro-5,4'-dinitro-biphenyl (ADDB) in goldfish (Carassius auratus) using the micronucleus test and the comet assay.
Mutation research 2004;560(1):33-40.
2004: Watanabe Masahiko; Enomoto Shigeki; Takamura-Enya Takeji; Nakano Tsuyoshi; Koyama Kotaro; Sugimura Takashi; Wakabayashi Keiji
Enzymatic properties of pierisin-1 and its N-terminal domain, a guanine-specific ADP-ribosyltransferase from the cabbage butterfly.
Journal of biochemistry 2004;135(4):471-7.
2004: Kitamura Tomohiro; Itoh Masaki; Noda Tetsuo; Matsuura Mamoru; Wakabayashi Keiji
Combined effects of cyclooxygenase-1 and cyclooxygenase-2 selective inhibitors on intestinal tumorigenesis in adenomatous polyposis coli gene knockout mice.
International journal of cancer. Journal international du cancer 2004;109(4):576-80.
2004: Totsuka Y; Takamura-Enya T; Nishigaki R; Sugimura T; Wakabayashi K
Mutagens formed from beta-carbolines with aromatic amines.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2004;802(1):135-41.
2003: Niho Naoko; Takahashi Mami; Shoji Yutaka; Takeuchi Yoshito; Matsubara Satoshi; Sugimura Takashi; Wakabayashi Keiji
Dose-dependent suppression of hyperlipidemia and intestinal polyp formation in Min mice by pioglitazone, a PPAR gamma ligand.
Cancer science 2003;94(11):960-4.
2003: Takahashi Mami; Mutoh Michihiro; Shoji Yutaka; Kamanaka Yoshihisa; Naka Masao; Maruyama Takayuki; Sugimura Takashi; Wakabayashi Keiji
Transfection of K-rasAsp12 cDNA markedly elevates IL-1beta- and lipopolysaccharide-mediated inducible nitric oxide synthase expression in rat intestinal epithelial cells.
Oncogene 2003;22(48):7667-76.
2003: Matsubara Satoshi; Shibata Hideyuki; Ishikawa Fumiyasu; Yokokura Teruo; Takahashi Mami; Sugimura Takashi; Wakabayashi Keiji
Suppression of Helicobacter pylori-induced gastritis by green tea extract in Mongolian gerbils.
Biochemical and biophysical research communications 2003;310(3):715-9.
2003: Niho Naoko; Takahashi Mami; Kitamura Tomohiro; Shoji Yutaka; Itoh Masaki; Noda Tetsuo; Sugimura Takashi; Wakabayashi Keiji
Concomitant suppression of hyperlipidemia and intestinal polyp formation in Apc-deficient mice by peroxisome proliferator-activated receptor ligands.
Cancer research 2003;63(18):6090-5.
2003: Totsuka Yukari; Kawanishi Masanobu; Nishigaki Rena; Matsukawa Kazuki; Yagi Takashi; Takamura-Enya Takeji; Watanabe Masahiko; Sugimura Takashi; Wakabayashi Keiji
Analysis of HPRT and supF mutations caused by pierisin-1, a guanine specific ADP-ribosylating toxin derived from the cabbage butterfly.
Chemical research in toxicology 2003;16(8):945-52.
2003: Kitamura Tomohiro; Itoh Masaki; Noda Tetsuo; Tani Kousuke; Kobayashi Michiyoshi; Maruyama Takayuki; Kobayashi Kaoru; Ohuchida Shuichi; Sugimura Takashi; Wakabayashi Keiji
Combined effects of prostaglandin E receptor subtype EP1 and subtype EP4 antagonists on intestinal tumorigenesis in adenomatous polyposis coli gene knockout mice.
Cancer science 2003;94(7):618-21.
2003: Watanabe Tetsushi; Hasei Tomohiro; Takahashi Yoshifumi; Otake Shuhei; Murahashi Tsuyoshi; Takamura Takeji; Hirayama Teruhisa; Wakabayashi Keiji
Mutagenic activity and quantification of nitroarenes in surface soil in the Kinki region of Japan.
Mutation research 2003;538(1-2):121-31.
2003: Kawamori Toshihiko; Uchiya Naoaki; Sugimura Takashi; Wakabayashi Keiji
Enhancement of colon carcinogenesis by prostaglandin E2 administration.
Carcinogenesis 2003;24(5):985-90.
2003: Murahashi Tsuyoshi; Watanabe Tetsushi; Otake Shuhei; Hattori Yoshimasa; Takamura Takeji; Wakabayashi Keiji; Hirayama Teruhisa
Determination of 3-nitrobenzanthrone in surface soil by normal-phase high-performance liquid chromatography with fluorescence detection.
Journal of chromatography. A 2003;992(1-2):101-7.
2003: Takamura-Enya T; Ishihara J; Tahara S; Goto S; Totsuka Y; Sugimura T; Wakabayashi K
Analysis of estrogenic activity of foodstuffs and cigarette smoke condensates using a yeast estrogen screening method.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2003;41(4):543-50.
2003: Matsushima-Hibiya Yuko; Watanabe Masahiko; Hidari Kazuya I-P; Miyamoto Daisei; Suzuki Yasuo; Kasama Takeshi; Kasama Takashi; Koyama Kotaro; Sugimura Takashi; Wakabayashi Keiji
Identification of glycosphingolipid receptors for pierisin-1, a guanine-specific ADP-ribosylating toxin from the cabbage butterfly.
The Journal of biological chemistry 2003;278(11):9972-8.
2003: Shibata Hideyuki; Iimuro Masaki; Uchiya Naoaki; Kawamori Toshihiko; Nagaoka Masato; Ueyama Sadao; Hashimoto Shusuke; Yokokura Teruo; Sugimura Takashi; Wakabayashi Keiji
Preventive effects of Cladosiphon fucoidan against Helicobacter pylori infection in Mongolian gerbils.
Helicobacter 2003;8(1):59-65.
2003: Morisawa Tamie; Mizuno Tomoko; Ohe Takeshi; Watanabe Tetsushi; Hirayama Teruhisa; Nukaya Haruo; Shiozawa Tatsushi; Terao Yoshiyasu; Sawanishi Hiroyuki; Wakabayashi Keiji
Levels and behavior of 2-phenylbenzotoriazole-type mutagens in the effluent of a sewage treatment plant.
Mutation research 2003;534(1-2):123-32.
2003: Takamura-Enya Takeji; Ishikawa Satoko; Mochizuki Masataka; Wakabayashi Keiji
Development for an efficient synthesis method of 2'-deoxyguanosine-C8 adducts with several amino/nitro-arenes.
Nucleic acids research. Supplement (2001) 2003;(3):23-4.
2002: Iimuro Masaki; Shibata Hideyuki; Kawamori Toshihiko; Matsumoto Takayuki; Arakawa Tetsuo; Sugimura Takashi; Wakabayashi Keiji
Suppressive effects of garlic extract on Helicobacter pylori-induced gastritis in Mongolian gerbils.
Cancer letters 2002;187(1-2):61-8.
2002: Totsuka Yukari; Takamura-Enya Takeji; Kawahara Nobuo; Nishigaki Rena; Sugimura Takashi; Wakabayashi Keiji
Structure of DNA adduct formed with aminophenylnorharman, being responsible for the comutagenic action of norharman with aniline.
Chemical research in toxicology 2002;15(10):1288-94.
2002: Totsuka Yukari; Kataoka Hiroyuki; Takamura-Enya Takeji; Sugimura Takashi; Wakabayashi Keiji
In vitro and in vivo formation of aminophenylnorharman from norharman and aniline.
Mutation research 2002;506-507():49-54.
2002: Kitamura Tomohiro; Kawamori Toshihiko; Uchiya Naoaki; Itoh Masaki; Noda Tetsuo; Matsuura Mamoru; Sugimura Takashi; Wakabayashi Keiji
Inhibitory effects of mofezolac, a cyclooxygenase-1 selective inhibitor, on intestinal carcinogenesis.
Carcinogenesis 2002;23(9):1463-6.
2002: Watanabe Tetsushi; Takahashi Yoshifumi; Takahashi Tomoyuki; Nukaya Haruo; Terao Yoshiyasu; Hirayama Teruhisa; Wakabayashi Keiji
Seasonal fluctuation of the mutagenicity of river water in Fukui, Japan, and the contribution of 2-phenylbenzotriazole-type mutagens.
Mutation research 2002;519(1-2):187-97.
2002: Kanazawa Takashi; Kono Takuo; Watanabe Masahiko; Matsushima-Hibiya Yuko; Nakano Tsuyoshi; Koyama Kotaro; Tanaka Noriaki; Sugimura Takashi; Wakabayashi Keiji
Bcl-2 blocks apoptosis caused by pierisin-1, a guanine-specific ADP-ribosylating toxin from the cabbage butterfly.
Biochemical and biophysical research communications 2002;296(1):20-5.
2002: Watanabe Tetsushi; Shiozawa Tatsushi; Takahashi Yoshifumi; Takahashi Tomoyuki; Terao Yoshiyasu; Nukaya Haruo; Takamura Takeji; Sawanishi Hiroyuki; Ohe Takeshi; Hirayama Teruhisa; Wakabayashi Keiji
Mutagenicity of two 2-phenylbenzotriazole derivatives, 2-[2-(acetylamino)-4-(diethylamino)-5-methoxyphenyl]-5-amino- 7-bromo-4-chloro-2H-benzotriazole and 2-[2-(acetylamino)-4-(diallylamino)-5-methoxyphenyl]-5-amino-7-bromo-4-chloro-2H-benzotriazole and their detection in river water in Japan.
Mutagenesis 2002;17(4):293-9.
2002: Ohe Takeshi; Takata Tomoko; Maeda Yoko; Totsuka Yukari; Hada Noriyasu; Matsuoka Atsuko; Tanaka Noriho; Wakabayashi Keiji
Induction of sister chromatid exchanges and chromosome aberrations in cultured mammalian cells treated with aminophenylnorharman formed by norharman with aniline.
Mutation research 2002;515(1-2):181-8.
2002: Takamura-Enya Takeji; Watanabe Tetsushi; Tada Atsuko; Hirayama Teruhisa; Nukaya Haruo; Sugimura Takashi; Wakabayashi Keiji
Identification of a new mutagenic polychlorinated biphenyl derivative in the Waka River, Wakayama, Japan, showing activation of an aryl hydrocarbon receptor-dependent transcription.
Chemical research in toxicology 2002;15(3):419-25.
2002: Sasahara Yasuyoshi; Mutoh Michihiro; Takahashi Mami; Fukuda Kazunori; Tanaka Naomi; Sugimura Takashi; Wakabayashi Keiji
Suppression of promoter-dependent transcriptional activity of inducible nitric oxide synthase by sodium butyrate in colon cancer cells.
Cancer letters 2002;177(2):155-61.
2002: Shibata Hideyuki; Ohta Toshihisa; Iimuro Masaki; Kitamura Tomohiro; Yokokura Teruo; Wakabayashi Keiji
Suppression of Helicobacter pylori-induced gastritis by urease inhibitors in Mongolian gerbils.
Gan to kagaku ryoho. Cancer & chemotherapy 2002;29 Suppl 1():154-8.
2002: Mutoh Michihiro; Watanabe Kouji; Kitamura Tomohiro; Shoji Yutaka; Takahashi Mami; Kawamori Toshihiko; Tani Kousuke; Kobayashi Michiyoshi; Maruyama Takayuki; Kobayashi Kaoru; Ohuchida Shuichi; Sugimoto Yukihiko; Narumiya Shuh; Sugimura Takashi; Wakabayashi Keiji
Involvement of prostaglandin E receptor subtype EP(4) in colon carcinogenesis.
Cancer research 2002;62(1):28-32.
2002: Watanabe Masahiko; Takamura-Enya Takeji; Kanazawa Takashi; Totsuka Yukari; Matsushima-Hibiya Yuko; Koyama Kotaro; Sugimura Takashi; Wakabayashi Keiji
Mono(ADP-ribosyl)ation of DNA by apoptosis-inducing protein, pierisin.
Nucleic acids research. Supplement (2001) 2002;(2):243-4.
2002: Kawamori Toshihiko; Nakatsugi Seiichi; Ohta Toshihisa; Sugimura Takashi; Wakabayashi Keiji
Chemopreventive effects of nimesulide, a selective cyclooxygenase-2 inhibitor, against PhIP-induced mammary carcinogenesis.
Advances in experimental medicine and biology 2002;507():371-6.
2002: Kawamori Toshihiko; Wakabayashi Keiji
COX-2 and prostanoid receptors: good targets for chemoprevention.
Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer 2002;21(2):149-53.
2001: Kawamori T; Uchiya N; Nakatsugi S; Watanabe K; Ohuchida S; Yamamoto H; Maruyama T; Kondo K; Sugimura T; Wakabayashi K
Chemopreventive effects of ONO-8711, a selective prostaglandin E receptor EP(1) antagonist, on breast cancer development.
Carcinogenesis 2001;22(12):2001-4.
2001: Kawamori T; Uchiya N; Kitamura T; Ohuchida S; Yamamoto H; Maruyama T; Sugimura T; Wakabayashi K
Evaluation of a selective prostaglandin E receptor EP1 antagonist for potential properties in colon carcinogenesis.
Anticancer research 2001;21(6A):3865-9.
2001: Watanabe T; Nukaya H; Terao Y; Takahashi Y; Tada A; Takamura T; Sawanishi H; Ohe T; Hirayama T; Sugimura T; Wakabayashi K
Synthesis of 2-phenylbenzotriazole-type mutagens, PBTA-5 and PBTA-6, and their detection in river water from Japan.
Mutation research 2001;498(1-2):107-15.
2001: Takamura-Enya T; Watanabe M; Totsuka Y; Kanazawa T; Matsushima-Hibiya Y; Koyama K; Sugimura T; Wakabayashi K
Mono(ADP-ribosyl)ation of 2'-deoxyguanosine residue in DNA by an apoptosis-inducing protein, pierisin-1, from cabbage butterfly.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(22):12414-9.
2001: Totsuka Y; Kawamori T; Hisada S; Mitsumori K; Ishihara J; Sugimura T; Wakabayashi K
Testicular toxicity in F344 rats by aminophenylnorharman, formed from norharman and aniline.
Toxicology and applied pharmacology 2001;175(2):169-75.
2001: Onozawa M; Fukuda K; Watanabe M; Ohtani M; Akaza H; Sugimura T; Wakabayashi K
Detection and cloning of a protein recognized by anti-human prostate-specific antigen (PSA) antibody in the rat ventral prostate.
Japanese journal of cancer research : Gann 2001;92(8):863-8.
2001: Ohta T; Shibata H; Kawamori T; Iimuro M; Sugimura T; Wakabayashi K
Marked reduction of Helicobacter pylori-induced gastritis by urease inhibitors, acetohydroxamic acid and flurofamide, in Mongolian gerbils.
Biochemical and biophysical research communications 2001;285(3):728-33.
2001: Hada N; Totsuka Y; Enya T; Tsurumaki K; Nakazawa M; Kawahara N; Murakami Y; Yokoyama Y; Sugimura T; Wakabayashi K
Structures of mutagens produced by the co-mutagen norharman with o- and m-toluidine isomers.
Mutation research 2001;493(1-2):115-26.
2001: Nukaya H; Shiozawa T; Tada A; Terao Y; Ohe T; Watanabe T; Asanoma M; Sawanishi H; Katsuhara T; Sugimura T; Wakabayashi K
Identification of 2-[2-(acetylamino)-4-amino-5-methoxyphenyl]-5-amino-7-bromo-4-chloro-2H-benzotriazole (PBTA-4) as a potent mutagen in river water in Kyoto and Aichi prefectures, Japan.
Mutation research 2001;492(1-2):73-80.
2001: Komatsu H; Watanabe M; Ohyama M; Enya T; Koyama K; Kanazawa T; Kawahara N; Sugimura T; Wakabayashi K
Phenanthroindolizidine alkaloids as cytotoxic substances in a Danaid butterfly, Ideopsis similis, against human cancer cells.
Journal of medicinal chemistry 2001;44(11):1833-6.
2001: Kanazawa T; Watanabe M; Matsushima-Hibiya Y; Kono T; Tanaka N; Koyama K; Sugimura T; Wakabayashi K
Distinct roles for the N- and C-terminal regions in the cytotoxicity of pierisin-1, a putative ADP-ribosylating toxin from cabbage butterfly, against mammalian cells.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(5):2226-31.
2001: Kawamori T; Totsuka Y; Ishihara J; Uchiya N; Sugimura T; Wakabayashi K
Induction of liver preneoplastic lesions by aminophenylnorharman, formed from norharman and aniline, in male F344 rats.
Cancer letters 2001;163(2):157-61.
2001: Kawamori T; Uchiya N; Watanabe K; Ohta T; Sugimura T; Wakabayashi K
Effects of heterocyclic amines with mammary gland carcinogenic potential on estrogenic response of uterus in ovariectomized rats.
Cancer letters 2001;162(1):31-7.
2000: Nakano K; Suyama K; Fukazawa H; Uchida M; Wakabayashi K; Shiozawa T; Terao Y
Chlorination of harman and norharman with sodium hypochlorite and co-mutagenicity of the chlorinated products.
Mutation research 2000;470(2):141-6.
2000: Nakatsugi S; Ohta T; Kawamori T; Mutoh M; Tanigawa T; Watanabe K; Sugie S; Sugimura T; Wakabayashi K
Chemoprevention by nimesulide, a selective cyclooxygenase-2 inhibitor, of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-induced mammary gland carcinogenesis in rats.
Japanese journal of cancer research : Gann 2000;91(9):886-92.
2000: Matsushima-Hibiya Y; Watanabe M; Kono T; Kanazawa T; Koyama K; Sugimura T; Wakabayashi K
Purification and cloning of pierisin-2, an apoptosis-inducing protein from the cabbage butterfly, Pieris brassicae.
European journal of biochemistry / FEBS 2000;267(18):5742-50.
2000: Tanigawa T; Kawamori T; Iimuro M; Ohta T; Higuchi K; Arakawa T; Sugimura T; Wakabayashi K
Marked enhancement by fish meal of Helicobacter pylori-induced gastritis in Mongolian gerbils.
Japanese journal of cancer research : Gann 2000;91(8):769-73.
2000: Watanabe K; Kawamori T; Nakatsugi S; Ohta T; Ohuchida S; Yamamoto H; Maruyama T; Kondo K; Narumiya S; Sugimura T; Wakabayashi K
Inhibitory effect of a prostaglandin E receptor subtype EP(1) selective antagonist, ONO-8713, on development of azoxymethane-induced aberrant crypt foci in mice.
Cancer letters 2000;156(1):57-61.
2000: Mutoh M; Takahashi M; Fukuda K; Komatsu H; Enya T; Matsushima-Hibiya Y; Mutoh H; Sugimura T; Wakabayashi K
Suppression by flavonoids of cyclooxygenase-2 promoter-dependent transcriptional activity in colon cancer cells: structure-activity relationship.
Japanese journal of cancer research : Gann 2000;91(7):686-91.
2000: Shiozawa T; Tada A; Nukaya H; Watanabe T; Takahashi Y; Asanoma M; Ohe T; Sawanishi H; Katsuhara T; Sugimura T; Wakabayashi K; Terao Y
Isolation and identification of a new 2-phenylbenzotriazole-type mutagen (PBTA-3) in the Nikko river in Aichi, Japan.
Chemical research in toxicology 2000;13(7):535-40.
2000: Takahashi M; Mutoh M; Kawamori T; Sugimura T; Wakabayashi K
Altered expression of beta-catenin, inducible nitric oxide synthase and cyclooxygenase-2 in azoxymethane-induced rat colon carcinogenesis.
Carcinogenesis 2000;21(7):1319-27.
2000: Takahashi M; Nakatsugi S; Sugimura T; Wakabayashi K
Frequent mutations of the beta-catenin gene in mouse colon tumors induced by azoxymethane.
Carcinogenesis 2000;21(6):1117-20.
2000: Mutoh M; Takahashi M; Fukuda K; Matsushima-Hibiya Y; Mutoh H; Sugimura T; Wakabayashi K
Suppression of cyclooxygenase-2 promoter-dependent transcriptional activity in colon cancer cells by chemopreventive agents with a resorcin-type structure.
Carcinogenesis 2000;21(5):959-63.
2000: Ohta T; Nakatsugi S; Watanabe K; Kawamori T; Ishikawa F; Morotomi M; Sugie S; Toda T; Sugimura T; Wakabayashi K
Inhibitory effects of Bifidobacterium-fermented soy milk on 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-induced rat mammary carcinogenesis, with a partial contribution of its component isoflavones.
Carcinogenesis 2000;21(5):937-41.
2000: Kawamori T; Takahashi M; Watanabe K; Ohta T; Nakatsugi S; Sugimura T; Wakabayashi K
Suppression of azoxymethane-induced colonic aberrant crypt foci by a nitric oxide synthase inhibitor.
Cancer letters 2000;148(1):33-7.
2000: Watanabe K; Kawamori T; Nakatsugi S; Wakabayashi K
COX-2 and iNOS, good targets for chemoprevention of colon cancer.
BioFactors (Oxford, England) 2000;12(1-4):129-33.
1999: Watanabe K; Kawamori T; Nakatsugi S; Ohta T; Ohuchida S; Yamamoto H; Maruyama T; Kondo K; Ushikubi F; Narumiya S; Sugimura T; Wakabayashi K
Role of the prostaglandin E receptor subtype EP1 in colon carcinogenesis.
Cancer research 1999;59(20):5093-6.
1999: Totsuka Y; Ushiyama H; Ishihara J; Sinha R; Goto S; Sugimura T; Wakabayashi K
Quantification of the co-mutagenic beta-carbolines, norharman and harman, in cigarette smoke condensates and cooked foods.
Cancer letters 1999;143(2):139-43.
1999: Watanabe M; Kono T; Matsushima-Hibiya Y; Kanazawa T; Nishisaka N; Kishimoto T; Koyama K; Sugimura T; Wakabayashi K
Molecular cloning of an apoptosis-inducing protein, pierisin, from cabbage butterfly: possible involvement of ADP-ribosylation in its activity.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(19):10608-13.
1999: Shiozawa T; Suyama K; Nakano K; Nukaya H; Sawanishi H; Oguri A; Wakabayashi K; Terao Y
Mutagenic activity of 2-phenylbenzotriazole derivatives related to a mutagen, PBTA-1, in river water.
Mutation research 1999;442(2):105-11.
1999: Onozawa M; Kawamori T; Baba M; Fukuda K; Toda T; Sato H; Ohtani M; Akaza H; Sugimura T; Wakabayashi K
Effects of a soybean isoflavone mixture on carcinogenesis in prostate and seminal vesicles of F344 rats.
Japanese journal of cancer research : Gann 1999;90(4):393-8.
1999: Kono T; Watanabe M; Koyama K; Kishimoto T; Fukushima S; Sugimura T; Wakabayashi K
Cytotoxic activity of pierisin, from the cabbage butterfly, Pieris rapae, in various human cancer cell lines.
Cancer letters 1999;137(1):75-81.
1999: Masutani M; Nozaki T; Nishiyama E; Shimokawa T; Tachi Y; Suzuki H; Nakagama H; Wakabayashi K; Sugimura T
Function of poly(ADP-ribose) polymerase in response to DNA damage: gene-disruption study in mice.
Molecular and cellular biochemistry 1999;193(1-2):149-52.
1998: Totsuka Y; Hada N; Matsumoto K; Kawahara N; Murakami Y; Yokoyama Y; Sugimura T; Wakabayashi K
Structural determination of a mutagenic aminophenylnorharman produced by the co-mutagen norharman with aniline.
Carcinogenesis 1998;19(11):1995-2000.
1998: Fukutake M; Nakatsugi S; Isoi T; Takahashi M; Ohta T; Mamiya S; Taniguchi Y; Sato H; Fukuda K; Sugimura T; Wakabayashi K
Suppressive effects of nimesulide, a selective inhibitor of cyclooxygenase-2, on azoxymethane-induced colon carcinogenesis in mice.
Carcinogenesis 1998;19(11):1939-42.
1998: Oguri A; Shiozawa T; Terao Y; Nukaya H; Yamashita J; Ohe T; Sawanishi H; Katsuhara T; Sugimura T; Wakabayashi K
Identification of a 2-phenylbenzotriazole (PBTA)-type mutagen, PBTA-2, in water from the Nishitakase River in Kyoto.
Chemical research in toxicology 1998;11(10):1195-200.
1998: Onozawa M; Fukuda K; Ohtani M; Akaza H; Sugimura T; Wakabayashi K
Effects of soybean isoflavones on cell growth and apoptosis of the human prostatic cancer cell line LNCaP.
Japanese journal of clinical oncology 1998;28(6):360-3.
1998: Oguri A; Suda M; Totsuka Y; Sugimura T; Wakabayashi K
Inhibitory effects of antioxidants on formation of heterocyclic amines.
Mutation research 1998;402(1-2):237-45.
1998: Ohata T; Fukuda K; Murakami A; Ohigashi H; Sugimura T; Wakabayashi K
Inhibition by 1'-acetoxychavicol acetate of lipopolysaccharide- and interferon-gamma-induced nitric oxide production through suppression of inducible nitric oxide synthase gene expression in RAW264 cells.
Carcinogenesis 1998;19(6):1007-12.
1998: Watanabe M; Kono T; Koyama K; Sugimura T; Wakabayashi K
Purification of pierisin, an inducer of apoptosis in human gastric carcinoma cells, from cabbage butterfly, Pieris rapae.
Japanese journal of cancer research : Gann 1998;89(5):556-61.
1998: Shiozawa T; Muraoka K; Nukaya H; Ohe T; Sawanishi H; Oguri A; Wakabayashi K; Sugimura T; Terao Y
Chemical synthesis of a novel aromatic amine mutagen isolated from water of the Nishitakase River in Kyoto and a possible route of its formation.
Chemical research in toxicology 1998;11(4):375-80.
1998: Takahashi M; Fukuda K; Sugimura T; Wakabayashi K
Beta-catenin is frequently mutated and demonstrates altered cellular location in azoxymethane-induced rat colon tumors.
Cancer research 1998;58(1):42-6.
1997: Nakatsugi S; Fukutake M; Takahashi M; Fukuda K; Isoi T; Taniguchi Y; Sugimura T; Wakabayashi K
Suppression of intestinal polyp development by nimesulide, a selective cyclooxygenase-2 inhibitor, in Min mice.
Japanese journal of cancer research : Gann 1997;88(12):1117-20.
1997: Takahashi M; Totsuka Y; Masuda M; Fukuda K; Oguri A; Yazawa K; Sugimura T; Wakabayashi K
Reduction in formation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-induced aberrant crypt foci in the rat colon by docosahexaenoic acid (DHA).
Carcinogenesis 1997;18(10):1937-41.
1997: Nukaya H; Yamashita J; Tsuji K; Terao Y; Ohe T; Sawanishi H; Katsuhara T; Kiyokawa K; Tezuka M; Oguri A; Sugimura T; Wakabayashi K
Isolation and chemical-structural determination of a novel aromatic amine mutagen in water from the Nishitakase River in Kyoto.
Chemical research in toxicology 1997;10(10):1061-6.
1997: Takahashi M; Fukutake M; Isoi T; Fukuda K; Sato H; Yazawa K; Sugimura T; Wakabayashi K
Suppression of azoxymethane-induced rat colon carcinoma development by a fish oil component, docosahexaenoic acid (DHA).
Carcinogenesis 1997;18(7):1337-42.
1997: Takahashi M; Fukuda K; Ohata T; Sugimura T; Wakabayashi K
Increased expression of inducible and endothelial constitutive nitric oxide synthases in rat colon tumors induced by azoxymethane.
Cancer research 1997;57(7):1233-7.
1997: Ohata T; Fukuda K; Takahashi M; Sugimura T; Wakabayashi K
Suppression of nitric oxide production in lipopolysaccharide-stimulated macrophage cells by omega 3 polyunsaturated fatty acids.
Japanese journal of cancer research : Gann 1997;88(3):234-7.
1996: Koyama K; Wakabayashi K; Masutani M; Koiwai K; Watanabe M; Yamazaki S; Kono T; Miki K; Sugimura T
Presence in Pieris rapae of cytotoxic activity against human carcinoma cells.
Japanese journal of cancer research : Gann 1996;87(12):1259-62.
1996: Mori M; Totsuka Y; Fukutome K; Yoshida T; Sugimura T; Wakabayashi K
Formation of DNA adducts by the co-mutagen norharman with aromatic amines.
Carcinogenesis 1996;17(7):1499-503.
1996: Inoue R; Ushijima T; Katami M; Kushida H; Wakabayashi K; Sato H; Asamoto M; Katsuki M; Sugimura T; Nagao M
Rare activation of the human c-Ha-ras transgene of mice in hemangioendothelial sarcomas and liver tumors induced by Glu-P-1.
Japanese journal of cancer research : Gann 1996;87(6):583-8.
1996: Shimoi K; Miyamura R; Mori T; Todo T; Ohtsuka E; Wakabayashi K; Kinae N
3-Amino-1,4-dimethyl-5H-pyrido[4,3-b]indole (Trp-P-1) inhibits the binding activity of T4 endonuclease V to UV-damaged DNA.
Carcinogenesis 1996;17(6):1279-83.
1996: Nagao M; Wakabayashi K; Ushijima T; Toyota M; Totsuka Y; Sugimura T
Human exposure to carcinogenic heterocyclic amines and their mutational fingerprints in experimental animals.
Environmental health perspectives 1996;104 Suppl 3():497-501.
1996: Fukutake M; Takahashi M; Ishida K; Kawamura H; Sugimura T; Wakabayashi K
Quantification of genistein and genistin in soybeans and soybean products.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1996;34(5):457-61.
1996: Totsuka Y; Fukutome K; Takahashi M; Takahashi S; Tada A; Sugimura T; Wakabayashi K
Presence of N2-(deoxyguanosin-8-yl)-2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (dG-C8-MeIQx) in human tissues.
Carcinogenesis 1996;17(5):1029-34.
1996: Sone K; Maeda M; Wakabayashi K; Takeichi N; Mori M; Sugimura T; Nagao M
Inhibition of hereditary hepatitis and liver tumor development in Long-Evans cinnamon rats by the copper-chelating agent trientine dihydrochloride.
Hepatology (Baltimore, Md.) 1996;23(4):764-70.
1996: Tada A; Wakabayashi K; Totsuka Y; Sugimura T; Tsuji K; Nukaya H
32P-Postlabeling analysis of a DNA adduct, an N2-acetyl derivative of guanine, formed in vitro by methylglyoxal and hydrogen peroxide in combination.
Mutation research 1996;351(2):173-80.
1996: Ochiai M; Watanabe M; Kushida H; Wakabayashi K; Sugimura T; Nagao M
DNA adduct formation, cell proliferation and aberrant crypt focus formation induced by PhIP in male and female rat colon with relevance to carcinogenesis.
Carcinogenesis 1996;17(1):95-8.
1996: Takahashi M; Fukutake M; Yokota S; Ishida K; Wakabayashi K; Sugimura T
Suppression of azoxymethane-induced aberrant crypt foci in rat colon by nimesulide, a selective inhibitor of cyclooxygenase 2.
Journal of cancer research and clinical oncology 1996;122(4):219-22.
1995: Hirose M; Wakabayashi K; Ochiai M; Kushida H; Sato H; Sugimura T; Nagao M
Formation and removal of DNA adducts in the liver of rats chronically fed the food-borne carcinogen, 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline.
Japanese journal of cancer research : Gann 1995;86(6):516-22.
1995: Oguri A; Karakama K; Arakawa N; Sugimura T; Wakabayashi K
Detection of mutagenicity of diphenyl ether herbicides in Salmonella typhimurium YG1026 and YG1021.
Mutation research 1995;346(1):57-60.
1995: Wakabayashi K; Kim I S; Kurosaka R; Yamaizumi Z; Ushiyama H; Takahashi M; Koyota S; Tada A; Nukaya H; Goto S
Identification of new mutagenic heterocyclic amines and quantification of known heterocyclic amines.
Princess Takamatsu symposia 1995;23():39-49.
1995: Masutani M; Nozaki T; Wakabayashi K; Sugimura T
Role of poly(ADP-ribose) polymerase in cell-cycle checkpoint mechanisms following gamma-irradiation.
Biochimie 1995;77(6):462-5.
1994: Ushijima T; Hosoya Y; Ochiai M; Kushida H; Wakabayashi K; Suzuki T; Hayashi M; Sofuni T; Sugimura T; Nagao M
Tissue-specific mutational spectra of 2-amino-3,4-dimethylimidazo[4,5-f]quinoline in the liver and bone marrow of lacI transgenic mice.
Carcinogenesis 1994;15(12):2805-9.
1994: Canzian F; Ushijima T; Serikawa T; Wakabayashi K; Sugimura T; Nagao M
Instability of microsatellites in rat colon tumors induced by heterocyclic amines.
Cancer research 1994;54(24):6315-7.
1994: Kushida H; Wakabayashi K; Sato H; Katami M; Kurosaka R; Nagao M
Dose-response study of MeIQx carcinogenicity in F344 male rats.
Cancer letters 1994;83(1-2):31-5.
1994: Tada A; Ochiai M; Wakabayashi K; Nukaya H; Sugimura T; Nagao M
Identification of N-(deoxyguanosin-8-yl)-2-amino-3,4-dimethylimidazo[4,5-f]quinoline (dG-C8-MeIQ) as a major adduct formed by MeIQ with nucleotides in vitro with DNA in vivo.
Carcinogenesis 1994;15(6):1275-8.
1994: Nukaya H; Koyota S; Jinno F; Ishida H; Wakabayashi K; Kurosaka R; Kim I S; Yamaizumi Z; Ushiyama H; Sugimura T
Structural determination of a new mutagenic heterocyclic amine, 2-amino-1,7,9-trimethylimidazo[4,5-g]quinoxaline (7,9-DiMeIgQx), present in beef extract.
Carcinogenesis 1994;15(6):1151-4.
1994: Fukutome K; Ochiai M; Wakabayashi K; Watanabe S; Sugimura T; Nagao M
Detection of guanine-C8-2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine adduct as a single spot on thin-layer chromatography by modification of the 32P-postlabeling method.
Japanese journal of cancer research : Gann 1994;85(2):113-7.
1994: Kim I S; Wakabayashi K; Kurosaka R; Yamaizumi Z; Jinno F; Koyota S; Tada A; Nukaya H; Takahashi M; Sugimura T
Isolation and identification of a new mutagen, 2-amino-4-hydroxy-methyl-3,8-dimethylimidazo[4,5-f]quinoxaline (4-CH2OH-8-MeIQx), from beef extract.
Carcinogenesis 1994;15(1):21-6.
1993: Ochiai M; Nagaoka H; Wakabayashi K; Tanaka Y; Kim S B; Tada A; Nukaya H; Sugimura T; Nagao M
Identification of N2-(deoxyguanosin-8-yl)-2-amino-3,8-dimethyl-imidazo[4,5- f]quinoxaline 3',5'-diphosphate, a major DNA adduct, detected by nuclease P1 modification of the 32P-postlabeling method, in the liver of rats fed MeIQx.
Carcinogenesis 1993;14(10):2165-70.
1993: Sone H; Wakabayashi K; Kushida H; Ochiai M; Sugimura T; Nagao M
Effects of chronic administration of low doses of 2-amino-3,8-dimethylimidazo-[4,5-f]quinoxaline on glutathione S-transferase placental form-positive foci development in the livers of rats fed a choline-deficient diet.
Japanese journal of cancer research : Gann 1993;84(8):859-64.
1993: Shephard S E; Wakabayashi K; Nagao M
Mutagenic activity of peptides and the artificial sweetener aspartame after nitrosation.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1993;31(5):323-9.
1993: Nukaya H; Inaoka Y; Ishida H; Tsuji K; Suwa Y; Wakabayashi K; Kosuge T
Modification of the amino group of guanosine by methylglyoxal and other alpha-ketoaldehydes in the presence of hydrogen peroxide.
Chemical & pharmaceutical bulletin 1993;41(4):649-53.
1993: Wakabayashi K; Ushiyama H; Takahashi M; Nukaya H; Kim S B; Hirose M; Ochiai M; Sugimura T; Nagao M
Exposure to heterocyclic amines.
Environmental health perspectives 1993;99():129-34.
1992: Yamamoto Y; Wakabayashi K; Niki E; Nagao M
Comparison of plasma levels of lipid hydroperoxides and antioxidants in hyperlipidemic Nagase analbuminemic rats, Sprague-Dawley rats, and humans.
Biochemical and biophysical research communications 1992;189(1):518-23.
1992: Nagaoka H; Wakabayashi K; Kim S B; Kim I S; Tanaka Y; Ochiai M; Tada A; Nukaya H; Sugimura T; Nagao M
Adduct formation at C-8 of guanine on in vitro reaction of the ultimate form of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine with 2'-deoxyguanosine and its phosphate esters.
Japanese journal of cancer research : Gann 1992;83(10):1025-9.
1992: Kurosaka R; Wakabayashi K; Ushiyama H; Nukaya H; Arakawa N; Sugimura T; Nagao M
Detection of 2-amino-1-methyl-6-(4-hydroxyphenyl)imidazo[4,5-b]pyridine in broiled beef.
Japanese journal of cancer research : Gann 1992;83(9):919-22.
1992: Kushida H; Wakabayashi K; Suzuki M; Takahashi S; Imaida K; Sugimura T; Nagao M
Suppression of spontaneous hepatocellular carcinoma development in C3H/HeNCrj mice by the lipophilic ascorbic acid, 2-O-octadecylascorbic acid (CV-3611).
Carcinogenesis 1992;13(6):913-5.
1992: Sone H; Wakabayashi K; Kushida H; Sugimura T; Nagao M
Induction of preneoplastic lesions by a low dose of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) in the livers of rats treated with carbon tetrachloride.
Carcinogenesis 1992;13(5):793-7.
1992: Sone H; Maeda M; Gotoh M; Wakabayashi K; Ono T; Yoshida M C; Takeichi N; Mori M; Hirohashi S; Sugimura T
Genetic linkage between copper accumulation and hepatitis/hepatoma development in LEC rats.
Molecular carcinogenesis 1992;5(3):199-204.
1991: Watkins B E; Suzuki M; Wallin H; Wakabayashi K; Alexander J; Vanderlaan M; Sugimura T; Esumi H
The effect of dose and enzyme inducers on the metabolism of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in rats.
Carcinogenesis 1991;12(12):2291-5.
1991: Nagao M; Nakayasu M; Aonuma S; Wakabayashi K; Hirose M; Sugimura T
Mutagenic properties of 2-amino-N6-hydroxyadenine in Salmonella and in Chinese hamster lung cells in culture.
Mutation research 1991;253(1):97-102.
1991: Watkins B E; Esumi H; Wakabayashi K; Nagao M; Sugimura T
Fate and distribution of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in rats.
Carcinogenesis 1991;12(6):1073-8.
1991: Ochiai M; Ogawa K; Wakabayashi K; Sugimura T; Nagase S; Esumi H; Nagao M
Induction of intestinal adenocarcinomas by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in Nagase analbuminemic rats.
Japanese journal of cancer research : Gann 1991;82(4):363-6.
1991: Nukaya H; Watanabe H; Ishida H; Tsuji K; Suwa Y; Wakabayashi K; Nagao M; Sugimura T; Kosuge T
Isolation and structural determination of a mutagenic substance in creatine pyrolysate.
Chemical & pharmaceutical bulletin 1991;39(2):533-5.
1990: Nukaya H; Iwami T; Ishida H; Tsuji K; Suwa Y; Wakabayashi K; Nagao M; Sugimura T; Kosuge T
N-2 acetylation of 2'-deoxyguanosine by coffee mutagens, methylglyoxal and hydrogen peroxide.
Mutation research 1990;245(4):251-7.
1990: Wakabayashi K
International Commission for Protection Against Environmental Mutagens and Carcinogens. ICPEMC Working Paper 7/1/3. Animal studies suggesting involvement of mutagen/carcinogen exposure in atherosclerosis.
Mutation research 1990;239(3):181-7.
1990: Hirose M; Wakabayashi K; Grivas S; De Flora S; Arakawa N; Nagao M; Sugimura T
Formation of a nitro derivative of 2-amino-3,4-dimethylimidazo[4,5-f]quinoline by photo-irradiation.
Carcinogenesis 1990;11(5):869-71.
1990: Yamashita K; Adachi M; Kato S; Nakagama H; Ochiai M; Wakabayashi K; Sato S; Nagao M; Sugimura T
DNA adducts formed by 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline in rat liver: dose-response on chronic administration.
Japanese journal of cancer research : Gann 1990;81(5):470-6.
1990: Wakabayashi K
Identification of food mutagens.
Progress in clinical and biological research 1990;340E():107-16.
1989: Takayama K; Yamashita K; Wakabayashi K; Sugimura T; Nagao M
DNA modification by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in rats.
Japanese journal of cancer research : Gann 1989;80(12):1145-8.
1989: Shioya M; Wakabayashi K; Yamashita K; Nagao M; Sugimura T
Formation of 8-hydroxydeoxyguanosine in DNA treated with fecapentaene-12 and -14.
Mutation research 1989;225(3):91-4.
1989: Wakabayashi K; Nagao M; Sugimura T
Mutagens and carcinogens produced by the reaction of environmental aromatic compounds with nitrite.
Cancer surveys 1989;8(2):385-99.
1988: Yamashita K; Wakabayashi K; Kitagawa Y; Nagao M; Sugimura T
32P-postlabeling analysis of DNA adducts in rat stomach with 1-nitrosoindole-3-acetonitrile, a direct-acting mutagenic indole compound formed by nitrosation.
Carcinogenesis 1988;9(10):1905-7.
1988: Tahira T; Ohgaki H; Wakabayashi K; Nagao M; Sugimura T
The inhibitory effect of thioproline on carcinogenesis induced by N-benzylmethylamine and nitrite.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1988;26(6):511-6.
1980: Takeda K; Shudo K; Okamoto T; Nagao M; Wakabayashi K; Sugimura T
Effect of methyl substitution on mutagenicity of 2-aminodipyrido.
Carcinogenesis 1980;1(11):889-92.

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