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JN Bradbeer

Research Profile

Living Beings

Physiology

Bone Resorption

Disorders

Concepts & Ideas

Procedures

Chemicals & Drugs

Anatomy

Osteoclasts

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Publications

TOP 3
Luciano Visentin; RA Dodds; M Valente; Paola Misiano; JN Bradbeer; S Oneta; X Liang; Maxine Gowen; Carlo Farina
A selective inhibitor of the osteoclastic V-H(+)-ATPase prevents bone loss in both thyroparathyroidectomized and ovariectomized rats.
Michael W Lark; George B Stroup; Shing-Mei Hwang; Ian E James; David J Rieman; FH Drake; JN Bradbeer; A Mathur; Karl F Erhard; Kenneth A Newlander; Stephen T Ross; Kevin L Salyers; Brian R Smith; William H Miller; William F Huffman; Maxine Gowen
Design and characterization of orally active Arg-Gly-Asp peptidomimetic vitronectin receptor antagonist SB 265123 for prevention of bone loss in osteoporosis.
William H Miller; WE Bondinell; Russell D Cousins; Karl F Erhard; Dalia R Jakas; Richard M Keenan; Thomas W Ku; Kenneth A Newlander; Stephen T Ross; R Curtis Haltiwanger; JN Bradbeer; FH Drake; Maxine Gowen; Sandra J Hoffman; Shing-Mei Hwang; Ian E James; Michael W Lark; BA Lechowska; David J Rieman; George B Stroup; Janice Vasko-Moser; DL Zembryki; Leonard M Azzarano; P C Adams; William F Huffman
Orally bioavailable nonpeptide vitronectin receptor antagonists with efficacy in an osteoporosis model.

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All Publications

2000: Luciano Visentin; RA Dodds; M Valente; Paola Misiano; JN Bradbeer; S Oneta; X Liang; Maxine Gowen; Carlo Farina
A selective inhibitor of the osteoclastic V-H(+)-ATPase prevents bone loss in both thyroparathyroidectomized and ovariectomized rats.
The Journal of clinical investigation 2000;106(2):309-18.
1999: Michael W Lark; George B Stroup; Shing-Mei Hwang; Ian E James; David J Rieman; FH Drake; JN Bradbeer; A Mathur; Karl F Erhard; Kenneth A Newlander; Stephen T Ross; Kevin L Salyers; Brian R Smith; William H Miller; William F Huffman; Maxine Gowen
Design and characterization of orally active Arg-Gly-Asp peptidomimetic vitronectin receptor antagonist SB 265123 for prevention of bone loss in osteoporosis.
The Journal of pharmacology and experimental therapeutics 1999;291(2):612-7.
1999: William H Miller; WE Bondinell; Russell D Cousins; Karl F Erhard; Dalia R Jakas; Richard M Keenan; Thomas W Ku; Kenneth A Newlander; Stephen T Ross; R Curtis Haltiwanger; JN Bradbeer; FH Drake; Maxine Gowen; Sandra J Hoffman; Shing-Mei Hwang; Ian E James; Michael W Lark; BA Lechowska; David J Rieman; George B Stroup; Janice Vasko-Moser; DL Zembryki; Leonard M Azzarano; P C Adams; William F Huffman
Orally bioavailable nonpeptide vitronectin receptor antagonists with efficacy in an osteoporosis model.
Bioorganic & medicinal chemistry letters 1999;9(13):1807-12.
1998: Mark E Nuttall; JN Bradbeer; George B Stroup; DP Nadeau; Sandra J Hoffman; H Zhao; S Rehm; Maxine Gowen
Idoxifene: a novel selective estrogen receptor modulator prevents bone loss and lowers cholesterol levels in ovariectomized rats and decreases uterine weight in intact rats.
Endocrinology 1998;139(12):5224-34.
1997: Bartholomew Votta; MA Levy; AM Badger; JN Bradbeer; RA Dodds; Ian E James; Scott Thompson; MJ Bossard; TJ Carr; JR Connor; Thaddeus Tomaszek; L Szewczuk; FH Drake; Daniel F Veber; Maxine Gowen
Peptide aldehyde inhibitors of cathepsin K inhibit bone resorption both in vitro and in vivo.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1997;12(9):1396-406.
1996: AM Badger; JN Bradbeer; Bartholomew Votta; John Lee; J L Adams; Don E Griswold
Pharmacological profile of SB 203580, a selective inhibitor of cytokine suppressive binding protein/p38 kinase, in animal models of arthritis, bone resorption, endotoxin shock and immune function.
The Journal of pharmacology and experimental therapeutics 1996;279(3):1453-61.
1996: Jeffrey C Boehm; J M Smietana; M E Sorenson; R S Garigipati; TF Gallagher; P L Sheldrake; JN Bradbeer; AM Badger; J T Laydon; John Lee; L M Hillegass; Don E Griswold; JJ Breton; MC Chabot-Fletcher; Jerry L Adams
1-substituted 4-aryl-5-pyridinylimidazoles: a new class of cytokine suppressive drugs with low 5-lipoxygenase and cyclooxygenase inhibitory potency.
Journal of medicinal chemistry 1996;39(20):3929-37.
1996: JN Bradbeer; R D Kapadia; S K Sarkar; H Zhao; George B Stroup; Barbara A Swift; David J Rieman; AM Badger
Disease-modifying activity of SK&F 106615 in rat adjuvant-induced arthritis. Multiparameter analysis of disease magnetic resonance imaging and bone mineral density measurements.
Arthritis and rheumatism 1996;39(3):504-14.
1994: S Walsh; RA Dodds; Ian E James; JN Bradbeer; Maxine Gowen
Monoclonal antibodies with selective reactivity against osteoblasts and osteocytes in human bone.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1994;9(11):1687-96.
1994: RA Dodds; Maxine Gowen; JN Bradbeer
Microcytophotometric analysis of human osteoclast metabolism: lack of activity in certain oxidative pathways indicates inability to sustain biosynthesis during resorption.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1994;42(5):599-606.