Herbert Waldmann

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Wilk Wolfram; Nören-Müller Andrea; Kaiser Markus; Waldmann Herbert
Biology-oriented combined solid- and solution-phase synthesis of a macroline-like compound collection.
Wetzel Stefan; Klein Karsten; Renner Steffen; Rauh Daniel; Oprea Tudor I; Mutzel Petra; Waldmann Herbert
Interactive exploration of chemical space with Scaffold Hunter.
Renner Steffen; van Otterlo Willem A L; Dominguez Seoane Marta; Möcklinghoff Sabine; Hofmann Bettina; Wetzel Stefan; Schuffenhauer Ansgar; Ertl Peter; Oprea Tudor I; Steinhilber Dieter; Brunsveld Luc; Rauh Daniel; Waldmann Herbert
Bioactivity-guided mapping and navigation of chemical space.

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All Publications

2009: Wilk Wolfram; Nören-Müller Andrea; Kaiser Markus; Waldmann Herbert
Biology-oriented combined solid- and solution-phase synthesis of a macroline-like compound collection.
Chemistry (Weinheim an der Bergstrasse, Germany) 2009;15(44):11976-84.
2009: Wetzel Stefan; Klein Karsten; Renner Steffen; Rauh Daniel; Oprea Tudor I; Mutzel Petra; Waldmann Herbert
Interactive exploration of chemical space with Scaffold Hunter.
Nature chemical biology 2009;5(8):581-3.
2009: Renner Steffen; van Otterlo Willem A L; Dominguez Seoane Marta; Möcklinghoff Sabine; Hofmann Bettina; Wetzel Stefan; Schuffenhauer Ansgar; Ertl Peter; Oprea Tudor I; Steinhilber Dieter; Brunsveld Luc; Rauh Daniel; Waldmann Herbert
Bioactivity-guided mapping and navigation of chemical space.
Nature chemical biology 2009;5(8):585-92.
2009: Vintonyak Viktor V; Antonchick Andrey P; Rauh Daniel; Waldmann Herbert
The therapeutic potential of phosphatase inhibitors.
Current opinion in chemical biology 2009;13(3):272-83.
2009: Yoshida Masahito; Hedberg Christian; Kaiser Markus; Waldmann Herbert
Traceless solid phase synthesis of natural product inspired cis-1,2-dehydrodecalins.
Chemical communications (Cambridge, England) 2009;(20):2926-8.
2009: Walther Thilo; Renner Steffen; Waldmann Herbert; Arndt Hans-Dieter
Synthesis and structure-activity correlation of a brunsvicamide-inspired cyclopeptide collection.
Chembiochem : a European journal of chemical biology 2009;10(7):1153-62.
2009: Nguyen Uyen T T; Guo Zhong; Delon Christine; Wu Yaowen; Deraeve Celine; Fränzel Benjamin; Bon Robin S; Blankenfeldt Wulf; Goody Roger S; Waldmann Herbert; Wolters Dirk; Alexandrov Kirill
Analysis of the eukaryotic prenylome by isoprenoid affinity tagging.
Nature chemical biology 2009;5(4):227-35.
2009: Tannert René; Hu Tai-Shan; Arndt Hans-Dieter; Waldmann Herbert
Solid-phase based total synthesis of Jasplakinolide by ring-closing metathesis.
Chemical communications (Cambridge, England) 2009;(12):1493-5.
2009: Wilk Wolfram; Waldmann Herbert; Kaiser Markus
Gamma-pyrone natural products--a privileged compound class provided by nature.
Bioorganic & medicinal chemistry 2009;17(6):2304-9.
2009: Weise Katrin; Triola Gemma; Brunsveld Luc; Waldmann Herbert; Winter Roland
Influence of the lipidation motif on the partitioning and association of N-Ras in model membrane subdomains.
Journal of the American Chemical Society 2009;131(4):1557-64.
2009: Triola Gemma; Wetzel Stefan; Ellinger Bernhard; Koch Marcus A; Hübel Katja; Rauh Daniel; Waldmann Herbert
ATP competitive inhibitors of D-alanine-D-alanine ligase based on protein kinase inhibitor scaffolds.
Bioorganic & medicinal chemistry 2009;17(3):1079-87.
2009: Alexander Michael; Gerauer Marc; Pechlivanis Markos; Popkirova Boriana; Dvorsky Radovan; Brunsveld Luc; Waldmann Herbert; Kuhlmann Jürgen
Mapping the isoprenoid binding pocket of PDEdelta by a semisynthetic, photoactivatable N-Ras lipoprotein.
Chembiochem : a European journal of chemical biology 2009;10(1):98-108.
2009: Brunsveld Luc; Waldmann Herbert; Huster Daniel
Membrane binding of lipidated Ras peptides and proteins--the structural point of view.
Biochimica et biophysica acta 2009;1788(1):273-88.
2009: Weinrich Dirk; Jonkheijm Pascal; Niemeyer Christof M; Waldmann Herbert
Applications of protein biochips in biomedical and biotechnological research.
Angewandte Chemie (International ed. in English) 2009;48(42):7744-51.
2009: Knoth Tanja; Warburg Karin; Katzka Catherine; Rai Amrita; Wolf Alexander; Brockmeyer Andreas; Janning Petra; Reubold Thomas F; Eschenburg Susanne; Manstein Dietmar J; Hübel Katja; Kaiser Markus; Waldmann Herbert
The Ras pathway modulator melophlin A targets dynamins.
Angewandte Chemie (International ed. in English) 2009;48(39):7240-5.
2009: Westerlind Ulrika; Schröder Hendrik; Hobel Alexandra; Gaidzik Nikola; Kaiser Anton; Niemeyer Christof M; Schmitt Edgar; Waldmann Herbert; Kunz Horst
Tumor-associated MUC1 tandem-repeat glycopeptide microarrays to evaluate serum- and monoclonal-antibody specificity.
Angewandte Chemie (International ed. in English) 2009;48(44):8263-7.
2009: Kumar Kamal; Waldmann Herbert
Synthesis of natural product inspired compound collections.
Angewandte Chemie (International ed. in English) 2009;48(18):3224-42.
2009: Bulic Bruno; Pickhardt Marcus; Schmidt Boris; Mandelkow Eva-Maria; Waldmann Herbert; Mandelkow Eckhard
Development of tau aggregation inhibitors for Alzheimer's disease.
Angewandte Chemie (International ed. in English) 2009;48(10):1740-52.
2008: Waldmann Herbert; He Yu-Peng; Tan Hao; Arve Lars; Arndt Hans-Dieter
Flexible total synthesis of biphenomycin B.
Chemical communications (Cambridge, England) 2008;(43):5562-4.
2008: Guo Zhong; Wu Yao-Wen; Das Debapratim; Delon Christine; Cramer Janinna; Yu Shen; Thuns Sandra; Lupilova Nataliya; Waldmann Herbert; Brunsveld Luc; Goody Roger S; Alexandrov Kirill; Blankenfeldt Wulf
Structures of RabGGTase-substrate/product complexes provide insights into the evolution of protein prenylation.
The EMBO journal 2008;27(18):2444-56.
2008: Wang Zheming; Gu Christian; Colby Tom; Shindo Takayuki; Balamurugan Rengarajan; Waldmann Herbert; Kaiser Markus; van der Hoorn Renier A L
Beta-lactone probes identify a papain-like peptide ligase in Arabidopsis thaliana.
Nature chemical biology 2008;4(9):557-63.
2008: Govindaraju Thimmaiah; Jonkheijm Pascal; Gogolin Lars; Schroeder Hendrik; Becker Christian F W; Niemeyer Christof M; Waldmann Herbert
Surface immobilization of biomolecules by click sulfonamide reaction.
Chemical communications (Cambridge, England) 2008;(32):3723-5.
2008: Hübel Katja; Lessmann Torben; Waldmann Herbert
Chemical biology--identification of small molecule modulators of cellular activity by natural product inspired synthesis.
Chemical Society reviews 2008;37(7):1361-74.
2008: Triola Gemma; Brunsveld Luc; Waldmann Herbert
Racemization-free synthesis of S-alkylated cysteines via thiol-ene reaction.
The Journal of organic chemistry 2008;73(9):3646-9.
2008: Waldmann Herbert; Kühn Marc; Liu Wei; Kumar Kamal
Reagent-controlled domino synthesis of skeletally-diverse compound collections.
Chemical communications (Cambridge, England) 2008;(10):1211-3.
2008: Wehner Frank; Nören-Müller Andrea; Müller Oliver; Reis-Corrêa Ivan; Giannis Athanassios; Waldmann Herbert
Indoloquinolizidine derivatives as novel and potent apoptosis inducers and cell-cycle blockers.
Chembiochem : a European journal of chemical biology 2008;9(3):401-5.
2008: Jonkheijm Pascal; Weinrich Dirk; Schröder Hendrik; Niemeyer Christof M; Waldmann Herbert
Chemical strategies for generating protein biochips.
Angewandte Chemie (International ed. in English) 2008;47(50):9618-47.
2008: Bisek Nicola; Wetzel Stefan; Arndt Hans-Dieter; Waldmann Herbert
Synthesis and conformational analysis of stevastelin C3 analogues and their activity against the dual-specific vaccina H1-related phosphatase.
Chemistry (Weinheim an der Bergstrasse, Germany) 2008;14(29):8847-60.
2008: Waldmann Herbert; Khedkar Vivek; Dückert Heiko; Schürmann Markus; Oppel Iris M; Kumar Kamal
Asymmetric synthesis of natural product inspired tricyclic benzopyrones by an organocatalyzed annulation reaction.
Angewandte Chemie (International ed. in English) 2008;47(36):6869-72.
2008: Waldmann Herbert; Hu Tai-Shan; Renner Steffen; Menninger Sascha; Tannert René; Oda Toshiro; Arndt Hans-Dieter
Total synthesis of chondramide C and its binding mode to F-actin.
Angewandte Chemie (International ed. in English) 2008;47(34):6473-7.
2008: Nören-Müller Andrea; Wilk Wolfram; Saxena Krishna; Schwalbe Harald; Kaiser Markus; Waldmann Herbert
Discovery of a new class of inhibitors of Mycobacterium tuberculosis protein tyrosine phosphatase B by biology-oriented synthesis.
Angewandte Chemie (International ed. in English) 2008;47(32):5973-7.
2008: Mishra Rajesh; Bulic Bruno; Sellin Daniel; Jha Suman; Waldmann Herbert; Winter Roland
Small-molecule inhibitors of islet amyloid polypeptide fibril formation.
Angewandte Chemie (International ed. in English) 2008;47(25):4679-82.
2008: Jonkheijm Pascal; Weinrich Dirk; Köhn Maja; Engelkamp Hans; Christianen Peter C M; Kuhlmann Jürgen; Maan Jan C; Nüsse Dirk; Schroeder Hendrik; Wacker Ron; Breinbauer Rolf; Niemeyer Christof M; Waldmann Herbert
Photochemical surface patterning by the thiol-ene reaction.
Angewandte Chemie (International ed. in English) 2008;47(23):4421-4.
2008: Guo Zhong; Wu Yao-Wen; Tan Kui-Thong; Bon Robin S; Guiu-Rozas Ester; Delon Christine; Nguyen T Uyen; Wetzel Stefan; Arndt Sabine; Goody Roger S; Blankenfeldt Wulf; Alexandrov Kirill; Waldmann Herbert
Development of selective RabGGTase inhibitors and crystal structure of a RabGGTase-inhibitor complex.
Angewandte Chemie (International ed. in English) 2008;47(20):3747-50.
2007: Broussy Sylvain; Waldmann Herbert
Solid phase synthesis of highly substituted tetrahydropyrans by tandem ene-reaction/intramolecular Sakurai cyclization.
Journal of combinatorial chemistry 2007;9(6):1138-43.
2007: Hu Tai-Shan; Tannert René; Arndt Hans-Dieter; Waldmann Herbert
Solid-phase based synthesis of jasplakinolide analogs by intramolecular azide-alkyne cycloadditions.
Chemical communications (Cambridge, England) 2007;(38):3942-4.
2007: Vogel Alexander; Tan Kui-Thong; Waldmann Herbert; Feller Scott E; Brown Michael F; Huster Daniel
Flexibility of ras lipid modifications studied by 2H solid-state NMR and molecular dynamics simulations.
Biophysical journal 2007;93(8):2697-712.
2007: Corrêa Ivan R; Nören-Müller Andrea; Ambrosi Horst-Dieter; Jakupovic Sven; Saxena Krishna; Schwalbe Harald; Kaiser Markus; Waldmann Herbert
Identification of inhibitors for mycobacterial protein tyrosine phosphatase B (MptpB) by biology-oriented synthesis (BIOS).
Chemistry, an Asian journal 2007;2(9):1109-26.
2007: Wu Yao-Wen; Tan Kui-Thong; Waldmann Herbert; Goody Roger S; Alexandrov Kirill
Interaction analysis of prenylated Rab GTPase with Rab escort protein and GDP dissociation inhibitor explains the need for both regulators.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(30):12294-9.
2007: Lessmann Torben; Leuenberger Michele G; Menninger Sascha; Lopez-Canet Meritxell; Müller Oliver; Hümmer Stefan; Bormann Jenny; Korn Kerstin; Fava Eugenio; Zerial Marino; Mayer Thomas U; Waldmann Herbert
Natural product-derived modulators of cell cycle progression and viral entry by enantioselective oxa Diels-Alder reactions on the solid phase.
Chemistry & biology 2007;14(4):443-51.
2007: Bringezu Frank; Majerowicz Monika; Wen Shaoying; Reuther Guido; Tan Kui-Thong; Kuhlmann Jürgen; Waldmann Herbert; Huster Daniel
Membrane binding of a lipidated N-Ras protein studied in lipid monolayers.
European biophysics journal : EBJ 2007;36(4-5):491-8.
2007: Nguyen Uyen T T; Cramer Janina; Gomis Joaquin; Reents Reinhard; Gutierrez-Rodriguez Marta; Goody Roger S; Alexandrov Kirill; Waldmann Herbert
Exploiting the substrate tolerance of farnesyltransferase for site-selective protein derivatization.
Chembiochem : a European journal of chemical biology 2007;8(4):408-23.
2007: Schuffenhauer Ansgar; Ertl Peter; Roggo Silvio; Wetzel Stefan; Koch Marcus A; Waldmann Herbert
The scaffold tree--visualization of the scaffold universe by hierarchical scaffold classification.
Journal of chemical information and modeling 2007;47(1):47-58.
2007: Bulic Bruno; Pickhardt Marcus; Khlistunova Inna; Biernat Jacek; Mandelkow Eva-Maria; Mandelkow Eckhard; Waldmann Herbert
Rhodanine-based tau aggregation inhibitors in cell models of tauopathy.
Angewandte Chemie (International ed. in English) 2007;46(48):9215-9.
2007: Bierhals Katrin; Sondersorg Anna C; Lin Chiann-Tso; Rosenbaum Claudia; Waldmann Herbert; Wehner Frank
The epsilon-isoform of PKC mediates the hypertonic activation of cation channels in confluent monolayers of rat hepatocytes.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2007;20(5):397-404.
2007: Köhn Maja; Gutierrez-Rodriguez Marta; Jonkheijm Pascal; Wetzel Stefan; Wacker Ron; Schroeder Hendrik; Prinz Heino; Niemeyer Christof M; Breinbauer Rolf; Szedlacsek Stefan E; Waldmann Herbert
A microarray strategy for mapping the substrate specificity of protein tyrosine phosphatase.
Angewandte Chemie (International ed. in English) 2007;46(40):7700-3.
2007: Schroeder Hendrik; Ellinger Bernhard; Becker Christian F W; Waldmann Herbert; Niemeyer Christof M
Generation of live-cell microarrays by means of DNA-Directed immobilization of specific cell-surface ligands.
Angewandte Chemie (International ed. in English) 2007;46(22):4180-3.
2007: Umarye Jayant D; Lessmann Torben; García Ana B; Mamane Victor; Sommer Stefan; Waldmann Herbert
Biology-oriented synthesis of stereochemically diverse natural-product-derived compound collections by iterative allylations on a solid support.
Chemistry (Weinheim an der Bergstrasse, Germany) 2007;13(12):3305-19.
2006: Wu Yao-Wen; Waldmann Herbert; Reents Reinhard; Ebetino Frank H; Goody Roger S; Alexandrov Kirill
A protein fluorescence amplifier: continuous fluorometric assay for rab geranylgeranyltransferase.
Chembiochem : a European journal of chemical biology 2006;7(12):1859-61.
2006: Garcia Ana B; Lessmann Torben; Umarye Jayant D; Mamane Victor; Sommer Stefan; Waldmann Herbert
Stereocomplementary synthesis of a natural product-derived compound collection on a solid phase.
Chemical communications (Cambridge, England) 2006;(37):3868-70.
2006: Reuther Guido; Tan Kui-Thong; Vogel Alexander; Nowak Christine; Arnold Klaus; Kuhlmann Jürgen; Waldmann Herbert; Huster Daniel
The lipidated membrane anchor of full length N-Ras protein shows an extensive dynamics as revealed by solid-state NMR spectroscopy.
Journal of the American Chemical Society 2006;128(42):13840-6.
2006: Brunsveld Luc; Kuhlmann Jürgen; Alexandrov Kirill; Wittinghofer Alfred; Goody Roger S; Waldmann Herbert
Lipidated ras and rab peptides and proteins--synthesis, structure, and function.
Angewandte Chemie (International ed. in English) 2006;45(40):6622-46.
2006: Brunsveld L; Kuhlmann J; Waldmann H
Synthesis of palmitoylated Ras-peptides and -proteins.
Methods (San Diego, Calif.) 2006;40(2):151-65.
2006: Watzke Anja; Gutierrez-Rodriguez Marta; Köhn Maja; Wacker Ron; Schroeder Hendrik; Breinbauer Rolf; Kuhlmann Jürgen; Alexandrov Kirill; Niemeyer Christof M; Goody Roger S; Waldmann Herbert
A generic building block for C- and N-terminal protein-labeling and protein-immobilization.
Bioorganic & medicinal chemistry 2006;14(18):6288-306.
2006: Arndt Hans-Dieter; Niemeyer Christof M; Waldmann Herbert
Chemical biology education at Dortmund: a joint endeavor with the Max Planck Institute.
ACS chemical biology 2006;1(7):407-10.
2006: Lessmann Torben; Waldmann Herbert
Enantioselective synthesis on the solid phase.
Chemical communications (Cambridge, England) 2006;(32):3380-9.
2006: Müller Daniela; Krick Anja; Kehraus Stefan; Mehner Christian; Hart Mark; Küpper Frithjof C; Saxena Krishna; Prinz Heino; Schwalbe Harald; Janning Petra; Waldmann Herbert; König Gabriele M
Brunsvicamides A-C: sponge-related cyanobacterial peptides with Mycobacterium tuberculosis protein tyrosine phosphatase inhibitory activity.
Journal of medicinal chemistry 2006;49(16):4871-8.
2006: Reuther Guido; Tan Kui-Thong; Köhler Julia; Nowak Christine; Pampel André; Arnold Klaus; Kuhlmann Jürgen; Waldmann Herbert; Huster Daniel
Structural model of the membrane-bound C terminus of lipid-modified human N-ras protein.
Angewandte Chemie (International ed. in English) 2006;45(32):5387-90.
2006: de Araújo Aline Dantas; Palomo Jose M; Cramer Janina; Seitz Oliver; Alexandrov Kirill; Waldmann Herbert
Diels-Alder ligation of peptides and proteins.
Chemistry (Weinheim an der Bergstrasse, Germany) 2006;12(23):6095-109.
2006: Nören-Müller Andrea; Reis-Corrêa Ivan; Prinz Heino; Rosenbaum Claudia; Saxena Krishna; Schwalbe Harald J; Vestweber Dietmar; Cagna Guiseppe; Schunk Stefan; Schwarz Oliver; Schiewe Hajo; Waldmann Herbert
Discovery of protein phosphatase inhibitor classes by biology-oriented synthesis.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(28):10606-11.
2006: Seibert Simon F; Eguereva Ekaterina; Krick Anja; Kehraus Stefan; Voloshina Elena; Raabe Gerhard; Fleischhauer Jörg; Leistner Eckhard; Wiese Michael; Prinz Heino; Alexandrov Kirill; Janning Petra; Waldmann Herbert; König Gabriele M
Polyketides from the marine-derived fungus Ascochyta salicorniae and their potential to inhibit protein phosphatases.
Organic & biomolecular chemistry 2006;4(11):2233-40.
2006: Basu Sudipta; Waldmann Herbert
Regioselectivity in the formation of small- and medium-sized cyclic ethers by diene-ene ring-closing metathesis.
The Journal of organic chemistry 2006;71(10):3977-9.
2006: Biel Markus; Deck Patrick; Giannis Athanassios; Waldmann Herbert
Synthesis and evaluation of acyl protein thioesterase 1 (APT1) inhibitors.
Chemistry (Weinheim an der Bergstrasse, Germany) 2006;12(15):4121-43.
2006: Dursina Beatrice; Reents Reinhard; Delon Christine; Wu Yaowen; Kulharia Mahesh; Thutewohl Michael; Veligodsky Alexei; Kalinin Alexandr; Evstifeev Vladimir; Ciobanu Doina; Szedlacsek Stefan E; Waldmann Herbert; Goody Roger S; Alexandrov Kirill
Identification and specificity profiling of protein prenyltransferase inhibitors using new fluorescent phosphoisoprenoids.
Journal of the American Chemical Society 2006;128(9):2822-35.
2006: Watzke Anja; Köhn Maja; Gutierrez-Rodriguez Marta; Wacker Ron; Schröder Hendrik; Breinbauer Rolf; Kuhlmann Jürgen; Alexandrov Kirill; Niemeyer Christof M; Goody Roger S; Waldmann Herbert
Site-selective protein immobilization by Staudinger ligation.
Angewandte Chemie (International ed. in English) 2006;45(9):1408-12.
2006: Pylypenko Olena; Rak Alexey; Durek Thomas; Kushnir Susanna; Dursina Beatrice E; Thomae Nicolas H; Constantinescu Alexandru T; Brunsveld Luc; Watzke Anja; Waldmann Herbert; Goody Roger S; Alexandrov Kirill
Structure of doubly prenylated Ypt1:GDI complex and the mechanism of GDI-mediated Rab recycling.
The EMBO journal 2006;25(1):13-23.
2006: Gottlieb D; Grunwald C; Nowak C; Kuhlmann J; Waldmann H
Intein-mediated in vitro synthesis of lipidated Ras proteins.
Chemical communications (Cambridge, England) 2006;(3):260-2.
2006: Nicolini Chiara; Baranski Jörg; Schlummer Stefanie; Palomo José; Lumbierres-Burgues Maria; Kahms Martin; Kuhlmann Jürgen; Sanchez Susana; Gratton Enrico; Waldmann Herbert; Winter Roland
Visualizing association of N-ras in lipid microdomains: influence of domain structure and interfacial adsorption.
Journal of the American Chemical Society 2006;128(1):192-201.
2006: Schlummer Stefanie; Vetter Robin; Kuder Norman; Henkel Andreas; Chen Yong-Xiang; Li Yan-Mei; Kuhlmann Jürgen; Waldmann Herbert
Influence of serine O-glycosylation or O-phosphorylation close to the vJun nuclear localisation sequence on nuclear import.
Chembiochem : a European journal of chemical biology 2006;7(1):88-97.
2006: Palomo Jose M; Lumbierres Maria; Waldmann Herbert
Efficient solid-phase lipopeptide synthesis employing the ellman sulfonamide linker.
Angewandte Chemie (International ed. in English) 2006;45(3):477-81.
2006: Koch M A; Waldmann H
Protein structure similarity clustering and natural product structure as guiding principles for chemical genomics.
Ernst Schering Research Foundation workshop 2006;(58):89-109.
2005: de Araújo Aline Dantas; Palomo Jose M; Cramer Janina; Köhn Maja; Schröder Hendrik; Wacker Ron; Niemeyer Christof; Alexandrov Kirill; Waldmann Herbert
Diels-Alder ligation and surface immobilization of proteins.
Angewandte Chemie (International ed. in English) 2005;45(2):296-301.
2005: Sommer Stefan; Waldmann Herbert
Solid phase synthesis of a spiro[5.5]ketal library.
Chemical communications (Cambridge, England) 2005;(45):5684-6.
2005: Hoffmann J; Feng Y; vom Hagen F; Hillenbrand A; Lin J; Erber R; Vajkoczy P; Gourzoulidou E; Waldmann H; Giannis A; Wolburg H; Shani M; Jaeger V; Weich H A; Preissner K T; Hoffmann S; Deutsch U; Hammes H-P
Endothelial survival factors and spatial completion, but not pericyte coverage of retinal capillaries determine vessel plasticity.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005;19(14):2035-6.
2005: Lumbierres Maria; Palomo Jose M; Kragol Goran; Roehrs Sonja; Müller Oliver; Waldmann Herbert
Solid-phase synthesis of lipidated peptides.
Chemistry (Weinheim an der Bergstrasse, Germany) 2005;11(24):7405-15.
2005: Koch Marcus A; Schuffenhauer Ansgar; Scheck Michael; Wetzel Stefan; Casaulta Marco; Odermatt Alex; Ertl Peter; Waldmann Herbert
Charting biologically relevant chemical space: a structural classification of natural products (SCONP).
Proceedings of the National Academy of Sciences of the United States of America 2005;102(48):17272-7.
2005: Manger Michael; Scheck Michael; Prinz Heino; von Kries Jens Peter; Langer Thomas; Saxena Krishna; Schwalbe Harald; Fürstner Alois; Rademann Jörg; Waldmann Herbert
Discovery of Mycobacterium tuberculosis protein tyrosine phosphatase A (MptpA) inhibitors based on natural products and a fragment-based approach.
Chembiochem : a European journal of chemical biology 2005;6(10):1749-53.
2005: Vogel Alexander; Katzka Catherine P; Waldmann Herbert; Arnold Klaus; Brown Michael F; Huster Daniel
Lipid modifications of a Ras peptide exhibit altered packing and mobility versus host membrane as detected by 2H solid-state NMR.
Journal of the American Chemical Society 2005;127(35):12263-72.
2005: Deck Patrick; Pendzialek Dirk; Biel Markus; Wagner Melanie; Popkirova Boriana; Ludolph Björn; Kragol Goran; Kuhlmann Jürgen; Giannis Athanassios; Waldmann Herbert
Development and biological evaluation of acyl protein thioesterase 1 (APT1) inhibitors.
Angewandte Chemie (International ed. in English) 2005;44(31):4975-80.
2005: Dekker Frank J; Koch Marcus A; Waldmann Herbert
Protein structure similarity clustering (PSSC) and natural product structure as inspiration sources for drug development and chemical genomics.
Current opinion in chemical biology 2005;9(3):232-9.
2005: Bialy Laurent; Waldmann Herbert
Inhibitors of protein tyrosine phosphatases: next-generation drugs?
Angewandte Chemie (International ed. in English) 2005;44(25):3814-39.
2005: Balamurugan Rengarajan; Dekker Frank J; Waldmann Herbert
Design of compound libraries based on natural product scaffolds and protein structure similarity clustering (PSSC).
Molecular bioSystems 2005;1(1):36-45.
2005: Koch Marcus A; Waldmann Herbert
Protein structure similarity clustering and natural product structure as guiding principles in drug discovery.
Drug discovery today 2005;10(7):471-83.
2005: Watzke Anja; Brunsveld Luc; Durek Thomas; Alexandrov Kirill; Rak Alexey; Goody Roger S; Waldmann Herbert
Chemical biology of protein lipidation: semi-synthesis and structure elucidation of prenylated RabGTPases.
Organic & biomolecular chemistry 2005;3(7):1157-64.
2005: Brunsveld Luc; Watzke Anja; Durek Thomas; Alexandrov Kirill; Goody Roger S; Waldmann Herbert
Synthesis of functionalized rab GTPases by a combination of solution- or solid-phase lipopeptide synthesis with expressed protein ligation.
Chemistry (Weinheim an der Bergstrasse, Germany) 2005;11(9):2756-72.
2005: Rocks Oliver; Peyker Anna; Kahms Martin; Verveer Peter J; Koerner Carolin; Lumbierres Maria; Kuhlmann Jürgen; Waldmann Herbert; Wittinghofer Alfred; Bastiaens Philippe I H
An acylation cycle regulates localization and activity of palmitoylated Ras isoforms.
Science (New York, N.Y.) 2005;307(5716):1746-52.
2005: Gourzoulidou Eleni; Carpintero Mercedes; Baumhof Patrick; Giannis Athanassios; Waldmann Herbert
Inhibition of angiogenesis-relevant receptor tyrosine kinases by sulindac analogues.
Chembiochem : a European journal of chemical biology 2005;6(3):527-31.
2005: Rosenbaum Claudia; Röhrs Sonja; Müller Oliver; Waldmann Herbert
Modulation of MRP-1-mediated multidrug resistance by indomethacin analogues.
Journal of medicinal chemistry 2005;48(4):1179-87.
2005: Bayer Elena; Thutewohl Michael; Christner Claudia; Tradler Thomas; Osterkamp Frank; Waldmann Herbert; Bayer Peter
Identification of hPin1 inhibitors that induce apoptosis in a mammalian Ras transformed cell line.
Chemical communications (Cambridge, England) 2005;(4):516-8.
2005: Reents Reinhard; Wagner Melanie; Schlummer Stefanie; Kuhlmann Jürgen; Waldmann Herbert
Synthesis and application of fluorescent ras proteins for live-cell imaging.
Chembiochem : a European journal of chemical biology 2005;6(1):86-94.
2005: Dursina Beatrice-Elena; Reents Reinhard; Niculae Anca; Veligodsky Alexei; Breitling Reinhard; Pyatkov Konstantin; Waldmann Herbert; Goody Roger S; Alexandrov Kirill
A genetically encodable microtag for chemo-enzymatic derivatization and purification of recombinant proteins.
Protein expression and purification 2005;39(1):71-81.
2005: Goody Roger S; Durek Thomas; Waldmann Herbert; Brunsveld Lucas; Alexandrov Kirill
Application of protein semisynthesis for the construction of functionalized posttranslationally modified rab GTPases.
Methods in enzymology 2005;403():29-42.
2005: Koch M A; Waldmann H
Protein domain fold similarity and natural product structure as guiding principles for compound library design.
Ernst Schering Research Foundation workshop 2005;(51):1-18.
2004: Durek Thomas; Alexandrov Kirill; Goody Roger S; Hildebrand Alexandra; Heinemann Ines; Waldmann Herbert
Synthesis of fluorescently labeled mono- and diprenylated Rab7 GTPase.
Journal of the American Chemical Society 2004;126(50):16368-78.
2004: Koch Marcus A; Wittenberg Lars-Oliver; Basu Sudipta; Jeyaraj Duraiswamy A; Gourzoulidou Eleni; Reinecke Kerstin; Odermatt Alex; Waldmann Herbert
Compound library development guided by protein structure similarity clustering and natural product structure.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(48):16721-6.
2004: Kragol Goran; Lumbierres Maria; Palomo Jose M; Waldmann Herbert
Solid-phase synthesis of lipidated peptides.
Angewandte Chemie (International ed. in English) 2004;43(43):5839-42.
2004: Soulère Laurent; Aldrich Courtney; Daumke Oliver; Gail Robert; Kissau Lars; Wittinghofer Alfred; Waldmann Herbert
Synthesis of GTP-derived Ras ligands.
Chembiochem : a European journal of chemical biology 2004;5(10):1448-53.
2004: Karaguni Ioanna-Maria; Gourzoulidou Eleni; Carpintero Mercedes; Langerak Anette; Klein-Hitpass Ludger; Möröy Tarik; Winde Günther; Waldmann Herbert; Müller Oliver
SMAF-1 inhibits the APC/beta-catenin pathway and shows properties similar to those of the tumor suppressor protein APC.
Chembiochem : a European journal of chemical biology 2004;5(9):1267-70.
2004: Barun Okram; Sommer Stefan; Waldmann Herbert
Asymmetric solid-phase synthesis of 6,6-spiroketals.
Angewandte Chemie (International ed. in English) 2004;43(24):3195-9.
2004: Janosch Sascha; Nicolini Chiara; Ludolph Björn; Peters Carsten; Völkert Martin; Hazlet Theodore L; Gratton Enrico; Waldmann Herbert; Winter Roland
Partitioning of dual-lipidated peptides into membrane microdomains: lipid sorting vs peptide aggregation.
Journal of the American Chemical Society 2004;126(24):7496-503.
2004: Bialy Laurent; Waldmann Herbert
Total synthesis and biological evaluation of the protein phosphatase 2A inhibitor cytostatin and analogues.
Chemistry (Weinheim an der Bergstrasse, Germany) 2004;10(11):2759-80.
2004: Peters Carsten; Wolf Alexander; Wagner Melanie; Kuhlmann Jürgen; Waldmann Herbert
The cholesterol membrane anchor of the Hedgehog protein confers stable membrane association to lipid-modified proteins.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(23):8531-6.
2004: Reents Reinhard; Wagner Melanie; Kuhlmann Jürgen; Waldmann Herbert
Synthesis and application of fluorescence-labeled Ras-proteins for live-cell imaging.
Angewandte Chemie (International ed. in English) 2004;43(20):2711-4.
2004: Waldmann Herbert; Karaguni Ioanna-Maria; Carpintero Mercedes; Gourzoulidou Eleni; Herrmann Christian; Brockmann Christoph; Oschkinat Hartmut; Müller Oliver
Sulindac-derived Ras pathway inhibitors target the Ras-Raf interaction and downstream effectors in the Ras pathway.
Angewandte Chemie (International ed. in English) 2004;43(4):454-8.
2004: Müller Oliver; Gourzoulidou Eleni; Carpintero Mercedes; Karaguni Ioanna-Maria; Langerak Anette; Herrmann Christian; Möröy Tarik; Klein-Hitpass Ludger; Waldmann Herbert
Identification of potent Ras signaling inhibitors by pathway-selective phenotype-based screening.
Angewandte Chemie (International ed. in English) 2004;43(4):450-4.
2004: Rosenbaum Claudia; Baumhof Patrick; Mazitschek Ralf; Müller Oliver; Giannis Athanassios; Waldmann Herbert
Synthesis and biological evaluation of an indomethacin library reveals a new class of angiogenesis-related kinase inhibitors.
Angewandte Chemie (International ed. in English) 2004;43(2):224-8.
2004: Heinemann Ines; Völkert Martin; Waldmann Herbert
Synthesis of lipidated peptides.
Methods in molecular biology (Clifton, N.J.) 2004;283():221-32.
2003: Gerdes Jantje M; Waldmann Herbert
Direct mass spectrometric monitoring of solid phase organic syntheses.
Journal of combinatorial chemistry 2003;5(6):814-20.
2003: Rak Alexey; Pylypenko Olena; Durek Thomas; Watzke Anja; Kushnir Susanna; Brunsveld Lucas; Waldmann Herbert; Goody Roger S; Alexandrov Kirill
Structure of Rab GDP-dissociation inhibitor in complex with prenylated YPT1 GTPase.
Science (New York, N.Y.) 2003;302(5645):646-50.
2003: Völkert Martin; Uwai Koji; Tebbe Andreas; Popkirova Boriana; Wagner Melanie; Kuhlmann Jürgen; Waldmann Herbert
Synthesis and biological activity of photoactivatable N-ras peptides and proteins.
Journal of the American Chemical Society 2003;125(42):12749-58.
2003: Koch Marcus A; Breinbauer Rolf; Waldmann Herbert
Protein structure similarity as guiding principle for combinatorial library design.
Biological chemistry 2003;384(9):1265-72.
2003: Bialy Laurent; Waldmann Herbert
Synthesis and biological evaluation of cytostatin analogues.
Chemical communications (Cambridge, England) 2003;(15):1872-3.
2003: Rosenbaum Claudia; Katzka Catherine; Marzinzik Andreas; Waldmann Herbert
Traceless Fischer indole synthesis on the solid phase.
Chemical communications (Cambridge, England) 2003;(15):1822-3.
2003: Ludolph Björn; Waldmann Herbert
The synthesis of acid- and base-labile lipopeptides on solid support.
Chemistry (Weinheim an der Bergstrasse, Germany) 2003;9(15):3683-91.
2003: Peters Carsten; Waldmann Herbert
Solid-phase synthesis of peptide esters employing the hydrazide linker.
The Journal of organic chemistry 2003;68(15):6053-5.
2003: Stieber Frank; Grether Uwe; Mazitschek Ralph; Soric Natascha; Giannis Athanassios; Waldmann Herbert
Multistep solid-phase synthesis of an antibiotic and receptor tyrosine kinase inhibitors using the traceless phenylhydrazide linker.
Chemistry (Weinheim an der Bergstrasse, Germany) 2003;9(14):3282-91.
2003: Stieber Frank; Grether Uwe; Waldmann Herbert
Development of the traceless phenylhydrazide linker for solid-phase synthesis.
Chemistry (Weinheim an der Bergstrasse, Germany) 2003;9(14):3270-81.
2003: Kissau Lars; Stahl Petra; Mazitschek Ralph; Giannis Athannasios; Waldmann Herbert
Development of natural product-derived receptor tyrosine kinase inhibitors based on conservation of protein domain fold.
Journal of medicinal chemistry 2003;46(14):2917-31.
2003: Waldmann H
At the crossroads of chemistry and biology.
Bioorganic & medicinal chemistry 2003;11(14):3045-51.
2003: Thutewohl Michael; Kissau Lars; Popkirova Boriana; Karaguni Ionna-Maria; Nowak Thorsten; Bate Michael; Kuhlmann Jürgen; Müller Oliver; Waldmann Herbert
Identification of mono- and bisubstrate inhibitors of protein farnesyltransferase and inducers of apoptosis from a pepticinnamin E library.
Bioorganic & medicinal chemistry 2003;11(12):2617-26.
2003: Thutewohl Michael; Waldmann Herbert
Solid-phase synthesis of a pepticinnamin E library.
Bioorganic & medicinal chemistry 2003;11(12):2591-615.
2003: Huster Daniel; Vogel Alexander; Katzka Catherine; Scheidt Holger A; Binder Hans; Dante Silvia; Gutberlet Thomas; Zschörnig Olaf; Waldmann Herbert; Arnold Klaus
Membrane insertion of a lipidated ras peptide studied by FTIR, solid-state NMR, and neutron diffraction spectroscopy.
Journal of the American Chemical Society 2003;125(14):4070-9.
2003: Pylypenko Olena; Rak Alexey; Reents Reinhard; Niculae Anca; Sidorovitch Vadim; Cioaca Maria Daniela; Bessolitsyna Ekaterina; Thomä Nicolas H; Waldmann Herbert; Schlichting Ilme; Goody Roger S; Alexandrov Kirill
Structure of Rab escort protein-1 in complex with Rab geranylgeranyltransferase.
Molecular cell 2003;11(2):483-94.
2003: Köhn Maja; Wacker Ron; Peters Carsten; Schröder Hendrik; Soulère Laurent; Breinbauer Rolf; Niemeyer Christof M; Waldmann Herbert
Staudinger ligation: a new immobilization strategy for the preparation of small-molecule arrays.
Angewandte Chemie (International ed. in English) 2003;42(47):5830-4.
2003: Breinbauer R; Vetter I R; Waldmann H
From protein domains to drug candidates--natural products as guiding principles in compound library design and synthesis.
Ernst Schering Research Foundation workshop 2003;(42):167-88.
2002: Stieber Frank; Mazitschek Ralph; Soric Natascha; Giannis Athanassios; Waldmann Herbert
Traceless solid-phase synthesis of 2-aminothiazoles: receptor tyrosine kinase inhibitors with dual selectivity for Tie-2 and VEGFR-2.
Angewandte Chemie (International ed. in English) 2002;41(24):4757-61.
2002: Breinbauer Rolf; Manger Michael; Scheck Michael; Waldmann Herbert
Natural product guided compound library development.
Current medicinal chemistry 2002;9(23):2129-45.
2002: Brohm Dirk; Philippe Nicolas; Metzger Susanne; Bhargava Ajay; Müller Oliver; Lieb Folker; Waldmann Herbert
Solid-phase synthesis of dysidiolide-derived protein phosphatase inhibitors.
Journal of the American Chemical Society 2002;124(44):13171-8.
2002: Huttenloch Oliver; Laxman Eltepu; Waldmann Herbert
Solid-phase development of chiral phosphoramidite ligands for enantioselective conjugate addition reactions.
Chemistry (Weinheim an der Bergstrasse, Germany) 2002;8(20):4767-80.
2002: Thutewohl Michael; Kissau Lars; Popkirova Boriana; Karaguni Ionna-Maria; Nowak Thorsten; Bate Michael; Kuhlmann Jürgen; Müller Oliver; Waldmann Herbert
Solid-phase synthesis and biological evaluation of a pepticinnamin E library.
Angewandte Chemie (International ed. in English) 2002;41(19):3616-20; 3516.
2002: Völkert Martin; Koul Surrinder; Müller Gernot H; Lehnig Manfred; Waldmann Herbert
Phenylhydrazide as an enzyme-labile protecting group in peptide synthesis.
The Journal of organic chemistry 2002;67(20):6902-10.
2002: Peters Carsten; Wagner Melanie; Völkert Martin; Waldmann Herbert
Bridging the gap between cell biology and organic chemistry: chemical synthesis and biological application of lipidated peptides and proteins.
Die Naturwissenschaften 2002;89(9):381-90.
2002: Ludolph Björn; Eisele Frank; Waldmann Herbert
Solution- and solid-phase synthesis of the polybasic lipid-modified C termini of Rho A and K-Ras 4B.
Chembiochem : a European journal of chemical biology 2002;3(9):901-4.
2002: Breinbauer Rolf; Vetter Ingrid R; Waldmann Herbert
From protein domains to drug candidates-natural products as guiding principles in the design and synthesis of compound libraries.
Angewandte Chemie (International ed. in English) 2002;41(16):2879-90.
2002: Stieber Frank; Waldmann Herbert
Development of new acid-functionalized resins for combinatorial synthesis on solid supports.
Chemical communications (Cambridge, England) 2002;(16):1748-9.
2002: Kuhlmann Jürgen; Tebbe Andreas; Völkert Martin; Wagner Melanie; Uwai Koji; Waldmann Herbert
Photoactivatable synthetic Ras proteins: "baits" for the identification of plasma-membrane-bound binding partners of Ras.
Angewandte Chemie (International ed. in English) 2002;41(14):2546-50.
2002: Bialy Laurent; Waldmann Herbert
Synthesis of the protein phosphatase 2A inhibitor (4S,5S,6S,10S,11S,12S)-cytostatin.
Angewandte Chemie (International ed. in English) 2002;41(10):1748-51.
2002: Ludolph Björn; Eisele Frank; Waldmann Herbert
Solid-phase synthesis of lipidated peptides.
Journal of the American Chemical Society 2002;124(21):5954-5.
2002: Alexandrov Kirill; Heinemann Ines; Durek Thomas; Sidorovitch Vadim; Goody Roger S; Waldmann Herbert
Intein-mediated synthesis of geranylgeranylated Rab7 protein in vitro.
Journal of the American Chemical Society 2002;124(20):5648-9.
2002: Waldmann Herbert; Kissau Lars
The phosphorylation site database--a valuable tool for biologists and biochemists?
Angewandte Chemie (International ed. in English) 2002;41(7):1251.
2002: Stahl Petra; Kissau Lars; Mazitschek Ralph; Giannis Athanassios; Waldmann Herbert
Natural product derived receptor tyrosine kinase inhibitors: identification of IGF1R, Tie-2, and VEGFR-3 inhibitors.
Angewandte Chemie (International ed. in English) 2002;41(7):1174-8.
2002: Huttenloch Oliver; Laxman Eltepu; Waldmann Herbert
Combinatorial development of chiral phosphoramidite-ligands for enantioselective conjugate addition reactions.
Chemical communications (Cambridge, England) 2002;(7):673-5.
2002: Brohm Dirk; Metzger Susanne; Bhargava Ajay; Müller Oliver; Lieb Folker; Waldmann Herbert
Natural products are biologically validated starting points in structural space for compound library development: solid-phase synthesis of dysidiolide-derived phosphatase inhibitors.
Angewandte Chemie (International ed. in English) 2002;41(2):307-11.
2002: Reents Reinhard; Jeyaraj Duraiswamy A; Waldmann Herbert
Enzymatically cleavable linker groups in polymer-supported synthesis.
Drug discovery today 2002;7(1):71-6.
2001: Rak A; Reents R; Pylypenko O; Niculae A; Sidorovitch V; Thomä N H; Waldmann H; Schlichting I; Goody R S; Alexandrov K
Crystallization and preliminary X-ray diffraction analysis of the Rab escort protein-1 in complex with Rab geranylgeranyltransferase.
Journal of structural biology 2001;136(2):158-61.
2001: Stahl P; Kissau L; Mazitschek R; Huwe A; Furet P; Giannis A; Waldmann H
Total synthesis and biological evaluation of the nakijiquinones.
Journal of the American Chemical Society 2001;123(47):11586-93.
2001: Völkert M; Wagner M; Peters C; Waldmann H
The chemical biology of Ras lipidation.
Biological chemistry 2001;382(8):1133-45.
2001: Kadereit D; Deck P; Heinemann I; Waldmann H
Acid-labile protecting groups for the synthesis of lipidated peptides.
Chemistry (Weinheim an der Bergstrasse, Germany) 2001;7(6):1184-93.
2001: Kuhn K; Owen D J; Bader B; Wittinghofer A; Kuhlmann J; Waldmann H
Synthesis of functional Ras lipoproteins and fluorescent derivatives.
Journal of the American Chemical Society 2001;123(6):1023-35.
2001: Huttenloch O; Spieler J; Waldmann H
Chiral bicyclic phosphoramidites--a new class of ligands for asymmetric catalysis.
Chemistry (Weinheim an der Bergstrasse, Germany) 2001;7(3):671-5.
2001: Thomä N H; Iakovenko A; Kalinin A; Waldmann H; Goody R S; Alexandrov K
Allosteric regulation of substrate binding and product release in geranylgeranyltransferase type II.
Biochemistry 2001;40(1):268-74.
2000: Meseguer B; Alonso-Díaz D; Griebenow N; Herget T; Waldmann H
Solid-phase synthesis and biological evaluation of a teleocidin library--discovery of a selective PKCdelta down regulator.
Chemistry (Weinheim an der Bergstrasse, Germany) 2000;6(21):3943-57.
2000: Kadereit D; Kuhlmann J; Waldmann H
Linking the fields--the interplay of organic synthesis, biophysical chemistry, and cell biology in the chemical biology of protein lipidation.
Chembiochem : a European journal of chemical biology 2000;1(3):144-69.
2000: Kuder N; Zelinski T; Pathak T; Seitz O; Waldmann H
Synthesis of a triply phosphorylated pentapeptide from human tau-protein.
Bioorganic & medicinal chemistry 2000;8(10):2433-9.
2000: Thomä N H; Iakovenko A; Owen D; Scheidig A S; Waldmann H; Goody R S; Alexandrov K
Phosphoisoprenoid binding specificity of geranylgeranyltransferase type II.
Biochemistry 2000;39(39):12043-52.

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