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Herman Waldmann

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Frederico S Regateiro; Bruce Roberts; Herman Waldmann; Mindy Zhang; Elizabeth Adams; Kristian G Andersen; Alexander G Betz; Ye Chen; Stephen P Cobbold; Robert Hilbrands; Adrian R Kendal; Jianbo Ma; Shruti Madhiwalla; Kathleen F Nolan; Duncan Howie
Foxp3 expression is required for the induction of therapeutic tissue tolerance.
Ye Chen; Elizabeth Adams; Kristian G Andersen; Alexander G Betz; Frederico S Regateiro; David J Vaux; Herman Waldmann; Duncan Howie
Activation rather than Foxp3 expression determines that TGF-β-induced regulatory T cells out-compete naïve T cells in dendritic cell clustering.
Eleftherios I Agorogiannis; D Howie; F S Regateiro; Herman Waldmann; Stephen P Cobbold
Th17 cells induce a distinct graft rejection response that does not require IL-17A.

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All Publications

2012: Frederico S Regateiro; Bruce Roberts; Herman Waldmann; Mindy Zhang; Elizabeth Adams; Kristian G Andersen; Alexander G Betz; Ye Chen; Stephen P Cobbold; Robert Hilbrands; Adrian R Kendal; Jianbo Ma; Shruti Madhiwalla; Kathleen F Nolan; Duncan Howie
Foxp3 expression is required for the induction of therapeutic tissue tolerance.
Journal of immunology (Baltimore, Md. : 1950) 2012;189(8):3947-56.
2012: Ye Chen; Elizabeth Adams; Kristian G Andersen; Alexander G Betz; Frederico S Regateiro; David J Vaux; Herman Waldmann; Duncan Howie
Activation rather than Foxp3 expression determines that TGF-β-induced regulatory T cells out-compete naïve T cells in dendritic cell clustering.
European journal of immunology 2012;42(6):1436-48.
2012: Eleftherios I Agorogiannis; D Howie; F S Regateiro; Herman Waldmann; Stephen P Cobbold
Th17 cells induce a distinct graft rejection response that does not require IL-17A.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2012;12(4):835-45.
2011: Gonnie M Alkemade; Robert Hilbrands; Bart Keymeulen; Chantal Mathieu; Daniel Pipeleers; Evy Vandemeulebroucke; Herman Waldmann; Bart O Roep
Preservation of recall immunity in anti-CD3-treated recent onset type 1 diabetes patients.
Diabetes/metabolism research and reviews 2011;27(8):925-7.
2011: Frederico S Regateiro; Stephen P Cobbold; Duncan Howie; Herman Waldmann
TGF-β in transplantation tolerance.
Current opinion in immunology 2011;23(5):660-9.
2011: Frederico S Regateiro; Eleftherios I Agorogiannis; Stephen P Cobbold; David R Greaves; Duncan Howie; Kathleen F Nolan; Herman Waldmann
Generation of anti-inflammatory adenosine by leukocytes is regulated by TGF-β.
European journal of immunology 2011;41(10):2955-65.
2011: Adrian R Kendal; Jianbo Ma; Frederico S Regateiro; Elizabeth Adams; Ye Chen; Stephen P Cobbold; Shohei Hori; Herman Waldmann
Sustained suppression by Foxp3+ regulatory T cells is vital for infectious transplantation tolerance.
The Journal of experimental medicine 2011;208(10):2043-53.
2011: Stephen P Cobbold; Elizabeth Adams; Herman Waldmann
Biomarkers of transplantation tolerance: more hopeful than helpful?
Frontiers in immunology 2011;2():9.
2010: Geoff Hale; Peppy Rebello; Ibrahim Al Bakir; Emma Bolam; Pawel Wiczling; William J Jusko; Evy Vandemeulebroucke; Bart Keymeulen; Chantal Mathieu; Annette-G Ziegler; Lucienne Chatenoud; Herman Waldmann
Pharmacokinetics and antibody responses to the CD3 antibody otelixizumab used in the treatment of type 1 diabetes.
Journal of clinical pharmacology 2010;50(11):1238-48.
2010: Mark I Greene; Herman Waldmann
Regulation of the immune response.
Current opinion in immunology 2010;22(5):549-51.
2010: Christian Peter; Herman Waldmann; Stephen P Cobbold
mTOR signalling and metabolic regulation of T cell differentiation.
Current opinion in immunology 2010;22(5):655-61.
2010: Adrian R Kendal; Herman Waldmann
Infectious tolerance: therapeutic potential.
Current opinion in immunology 2010;22(5):560-5.
2010: Kathy O Lui; Ashleigh S Boyd; Stephen P Cobbold; Herman Waldmann; Paul J Fairchild
A role for regulatory T cells in acceptance of ESC-derived tissues transplanted across an major histocompatibility complex barrier.
Stem cells (Dayton, Ohio) 2010;28(10):1905-14.
2010: Herman Waldmann
Tolerance: an overview and perspectives.
Nature reviews. Nephrology 2010;6(10):569-76.
2010: Stephen P Cobbold; Elizabeth Adams; Kathleen F Nolan; Frederico S Regateiro; Herman Waldmann
Connecting the mechanisms of T-cell regulation: dendritic cells as the missing link.
Immunological reviews 2010;236():203-18.
2010: Claire A Farquhar; Alison M Paterson; Stephen P Cobbold; Hugo Garcia Rueda; Paul J Fairchild; Stephen F Yates; Elizabeth Adams; Nigel J Saunders; Herman Waldmann; Kathleen F Nolan
Tolerogenicity is not an absolute property of a dendritic cell.
European journal of immunology 2010;40(6):1728-37.
2010: Bart Keymeulen; Sophie Candon; Samira Fafi-Kremer; Anette Ziegler; Marianne Leruez-Ville; Chantal Mathieu; Evy Vandemeulebroucke; Markus Walter; laurent crenier; Eric THERVET; Christophe Legendre; Denis Pierard; Geoff Hale; Herman Waldmann; Jean-François Bach; Jean-Marie Seigneurin; Daniel Pipeleers; Lucienne Chatenoud
Transient Epstein-Barr virus reactivation in CD3 monoclonal antibody-treated patients.
Blood 2010;115(6):1145-55.
2010: Lynn D Poulton; Kathleen F Nolan; Corina Anastasaki; Herman Waldmann; E Elizabeth Patton
A novel role for Glucocorticoid-Induced TNF Receptor Ligand (Gitrl) in early embryonic zebrafish development.
The International journal of developmental biology 2010;54(5):815-25.
2009: Duncan Howie; Kathleen F Nolan; Stephen Daley; Emma Butterfield; Elizabeth Adams; Hugo Garcia-Rueda; Claire Thompson; Nigel J Saunders; Stephen P Cobbold; Yukiko Tone; Masahide Tone; Herman Waldmann
MS4A4B is a GITR-associated membrane adapter, expressed by regulatory T cells, which modulates T cell activation.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(7):4197-204.
2009: Stephen P Cobbold; Elizabeth Adams; Claire A Farquhar; Kathleen F Nolan; Duncan Howie; Kathy O Lui; Paul J Fairchild; Andrew L Mellor; David Ron; Herman Waldmann
Infectious tolerance via the consumption of essential amino acids and mTOR signaling.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(29):12055-60.
2009: Herman Waldmann; Stephen P Cobbold
Regulatory T cells: context matters.
Immunity 2009;30(5):613-5.
2009: Menna R Clatworthy; Peter J Friend; Roy Y Calne; Peppy Rebello; Geoff Hale; Herman Waldmann; Christopher J E Watson
Alemtuzumab (CAMPATH-1H) for the treatment of acute rejection in kidney transplant recipients: long-term follow-up.
Transplantation 2009;87(7):1092-5.
2009: Kathy O Lui; Herman Waldmann; Paul J Fairchild
Embryonic stem cells: overcoming the immunological barriers to cell replacement therapy.
Current stem cell research & therapy 2009;4(1):70-80.
2008: Zhanzhuo Li; Fleur Samantha Benghiat; Louis-Marie Charbonnier; Carole Kubjak; M N Rivas; S P Cobbold; Herman Waldmann; Vally De Wilde; M Petein; Frédéric A Schuind; Michel Goldman; Alain Le Moine
CD8+ T-Cell depletion and rapamycin synergize with combined coreceptor/stimulation blockade to induce robust limb allograft tolerance in mice.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2008;8(12):2527-36.
2008: Stephen Daley; Stephen P Cobbold; Herman Waldmann
Fc-disabled anti-mouse CD40L antibodies retain efficacy in promoting transplantation tolerance.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2008;8(11):2265-71.
2008: Herman Waldmann; Elizabeth Adams; Paul J Fairchild; Stephen Cobbold
Regulation and privilege in transplantation tolerance.
Journal of clinical immunology 2008;28(6):716-25.
2008: Herman Waldmann
Tolerance can be infectious.
Nature immunology 2008;9(9):1001-3.
2008: Herman Waldmann; Elizabeth Adams; Stephen P Cobbold
Reprogramming the immune system: co-receptor blockade as a paradigm for harnessing tolerance mechanisms.
Immunological reviews 2008;223():361-70.
2008: Zhaocai Zhou; Yukiko Tone; Xiaomin Song; Keiji Furuuchi; James D Lear; Herman Waldmann; Masahide Tone; Mark I Greene; Ramachandran Murali
Structural basis for ligand-mediated mouse GITR activation.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(2):641-5.
2008: Herman Waldmann
Special regulatory T cell review: The suppression problem!
Immunology 2008;123(1):11-2.
2007: Nathan J Robertson; Frances A Brook; Richard L Gardner; Stephen P Cobbold; Herman Waldmann; Paul J Fairchild
Embryonic stem cell-derived tissues are immunogenic but their inherent immune privilege promotes the induction of tolerance.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(52):20920-5.
2007: Paul J Fairchild; Nathan J Robertson; Stephen L Minger; Herman Waldmann
Embryonic stem cells: protecting pluripotency from alloreactivity.
Current opinion in immunology 2007;19(5):596-602.
2007: Stephen Daley; Jianbo Ma; Elizabeth Adams; Stephen P Cobbold; Herman Waldmann
A key role for TGF-beta signaling to T cells in the long-term acceptance of allografts.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(6):3648-54.
2007: Stephen F Yates; Alison M Paterson; Kathleen F Nolan; Stephen P Cobbold; Nigel J Saunders; Herman Waldmann; Paul J Fairchild
Induction of regulatory T cells and dominant tolerance by dendritic cells incapable of full activation.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(2):967-76.
2007: Nathan J Robertson; Paul J Fairchild; Herman Waldmann
Ectopic transplantation of tissues under the kidney capsule.
Methods in molecular biology (Clifton, N.J.) 2007;380():347-53.
2007: Kathleen F Nolan; Stephen P Cobbold; Herman Waldmann
SAGE analysis of cell types involved in tolerance induction.
Methods in molecular biology (Clifton, N.J.) 2007;380():225-51.
2007: Paul J Fairchild; Kathleen F Nolan; Herman Waldmann
Genetic modification of dendritic cells through the directed differentiation of embryonic stem cells.
Methods in molecular biology (Clifton, N.J.) 2007;380():59-72.
2006: Stephen P Cobbold; Elizabeth Adams; Luis Graca; Stephen Daley; Stephen Yates; Alison Paterson; Nathan J Robertson; Kathleen F Nolan; Paul J Fairchild; Herman Waldmann
Immune privilege induced by regulatory T cells in transplantation tolerance.
Immunological reviews 2006;213():239-55.
2006: Herman Waldmann; Elizabeth Adams; Paul J Fairchild; Stephen P Cobbold
Infectious tolerance and the long-term acceptance of transplanted tissue.
Immunological reviews 2006;212():301-13.
2006: Gerhard Glatting; Marguerite Müller; Bernd Koop; Kathrin Hohl; Claudia Friesen; Bernd Neumaier; Eleanor Berrie; Pru Bird; Geoff Hale; Norbert M Blumstein; Herman Waldmann; Donald Bunjes; Sven N Reske
Anti-CD45 monoclonal antibody YAML568: A promising radioimmunoconjugate for targeted therapy of acute leukemia.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2006;47(8):1335-41.
2006: Herman Waldmann; Tse-Ching Chen; Luis Graca; Elizabeth Adams; Stephen Daley; Stephen P Cobbold; Paul J Fairchild
Regulatory T cells in transplantation.
Seminars in immunology 2006;18(2):111-9.
2006: Luis Graca; Herman Waldmann
Reprogramming the immune system using antibodies.
Methods in molecular biology (Clifton, N.J.) 2006;333():247-68.
2006: Luis Graca; Stephen Daley; Paul J Fairchild; Stephen P Cobbold; Herman Waldmann
Co-receptor and co-stimulation blockade for mixed chimerism and tolerance without myelosuppressive conditioning.
BMC immunology 2006;7():9.
2006: Alasdair J Coles; Amanda Cox; Emmanuelle Le Page; Joanne Jones; S Anand Trip; Jackie Deans; Shaun Seaman; David H Miller; Geoff Hale; Herman Waldmann; D A S Compston
The window of therapeutic opportunity in multiple sclerosis: evidence from monoclonal antibody therapy.
Journal of neurology 2006;253(1):98-108.
2005: A M Paterson; Stephen F Yates; Kathleen F Nolan; Herman Waldmann
The new immunosuppression: intervention at the dendritic cell-T-cell interface.
Current drug targets. Immune, endocrine and metabolic disorders 2005;5(4):397-411.
2005: Amanda L Cox; Sara A J Thompson; Joanne L Jones; Vicki H Robertson; Geoff Hale; Herman Waldmann; D A S Compston; Alasdair J Coles
Lymphocyte homeostasis following therapeutic lymphocyte depletion in multiple sclerosis.
European journal of immunology 2005;35(11):3332-42.
2005: Nicolas Novitzky; Valda Thomas; Geoff Hale; Herman Waldmann
Myeloablative conditioning is well tolerated by older patients receiving T-cell-depleted grafts.
Bone marrow transplantation 2005;36(8):675-82.
2005: Herman Waldmann; Geoff Hale
CAMPATH: from concept to clinic.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2005;360(1461):1707-11.
2005: Bart Keymeulen; Evy Vandemeulebroucke; Anette-G Ziegler; Chantal Mathieu; Leonard Kaufman; Geoff Hale; Frans K Gorus; Michel Goldman; Markus Walter; Sophie Candon; Liliane Schandene; laurent crenier; Christophe E M De Block; Jean-Marie Seigneurin; Pieter De Pauw; Denis Pierard; Ilse Weets; Peppy Rebello; Pru Bird; Eleanor Berrie; Mark Frewin; Herman Waldmann; Jean-François Bach; Daniel Pipeleers; Lucienne Chatenoud
Insulin needs after CD3-antibody therapy in new-onset type 1 diabetes.
The New England journal of medicine 2005;352(25):2598-608.
2005: Christopher J E Watson; J Andrew Bradley; Peter J Friend; John Firth; Craig J Taylor; John R Bradley; Kenneth G C Smith; Sathia Thiru; Neville V Jamieson; Geoff Hale; Herman Waldmann; Roy Y Calne
Alemtuzumab (CAMPATH 1H) induction therapy in cadaveric kidney transplantation--efficacy and safety at five years.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2005;5(6):1347-53.
2005: Fleur Samantha Benghiat; Luis Graca; Michel Y Braun; Sophie Detienne; Fabrice Moore; Sofia Buonocore; Véronique Flamand; Herman Waldmann; Michel Goldman; Alain Le Moine
Critical influence of natural regulatory CD25+ T cells on the fate of allografts in the absence of immunosuppression.
Transplantation 2005;79(6):648-54.
2005: Luis Graca; Tse-Ching Chen; Alain Le Moine; Stephen P Cobbold; Duncan Howie; Herman Waldmann
Dominant tolerance: activation thresholds for peripheral generation of regulatory T cells.
Trends in immunology 2005;26(3):130-5.
2005: Paul J Fairchild; Nathan J Robertson; Siân Cartland; Kathleen F Nolan; Herman Waldmann
Cell replacement therapy and the evasion of destructive immunity.
Stem cell reviews 2005;1(2):159-67.
2005: Herman Waldmann; Luis Graca; Elizabeth Adams; Paul J Fairchild; Stephen P Cobbold
Regulatory T cells in transplantation tolerance.
Current topics in microbiology and immunology 2005;293():249-64.
2005: Paul J Fairchild; Kathleen F Nolan; Siân Cartland; Herman Waldmann
Embryonic stem cells: a novel source of dendritic cells for clinical applications.
International immunopharmacology 2005;5(1):13-21.
2004: Dawn Winsor-Hines; Christopher Merrill; Mark O'Mahony; Patricia E Rao; Stephen P Cobbold; Herman Waldmann; Douglas J Ringler; Paul D Ponath
Induction of immunological tolerance/hyporesponsiveness in baboons with a nondepleting CD4 antibody.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(7):4715-23.
2004: Paul J Fairchild; Siân Cartland; Kathleen F Nolan; Herman Waldmann
Embryonic stem cells and the challenge of transplantation tolerance.
Trends in immunology 2004;25(9):465-70.
2004: Geoff Hale; Peppy Rebello; Lee R Brettman; Christopher Fegan; Ben Kennedy; Eva Kimby; Mike Leach; Jeanette Lundin; Håkan Mellstedt; Paul Moreton; Andy C Rawstron; Herman Waldmann; Anders Osterborg; Peter Hillmen
Blood concentrations of alemtuzumab and antiglobulin responses in patients with chronic lymphocytic leukemia following intravenous or subcutaneous routes of administration.
Blood 2004;104(4):948-55.
2004: Herman Waldmann; Stephen P Cobbold
Exploiting tolerance processes in transplantation.
Science (New York, N.Y.) 2004;305(5681):209-12.
2004: Luis Graca; Alain Le Moine; Chun-Yen Lin; Paul J Fairchild; Stephen P Cobbold; Herman Waldmann
Donor-specific transplantation tolerance: the paradoxical behavior of CD4+CD25+ T cells.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(27):10122-6.
2004: Tse-Ching Chen; Herman Waldmann; Paul J Fairchild
Induction of dominant transplantation tolerance by an altered peptide ligand of the male antigen Dby.
The Journal of clinical investigation 2004;113(12):1754-62.
2004: Conor C Murphy; Kathrin Greiner; Jarka Heissigerova; Linda Duncan; Andrew Frost; John D Isaacs; Peppy Rebello; Herman Waldmann; Geoff Hale; John V Forrester; Andrew D Dick
Neutralizing tumor necrosis factor activity leads to remission in patients with refractory noninfectious posterior uveitis.
Archives of ophthalmology 2004;122(6):845-51.
2004: Stephen P Cobbold; Raquel Castejon; Elizabeth Adams; Diana Zelenika; Luis Graca; Susan Humm; Herman Waldmann
Induction of foxP3+ regulatory T cells in the periphery of T cell receptor transgenic mice tolerized to transplants.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(10):6003-10.
2004: Tse-Ching Chen; Stephen P Cobbold; Paul J Fairchild; Herman Waldmann
Generation of anergic and regulatory T cells following prolonged exposure to a harmless antigen.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(10):5900-7.
2004: Herman Waldmann; Luis Graca; Stephen P Cobbold; Elizabeth Adams; Masahide Tone; Yukiko Tone
Regulatory T cells and organ transplantation.
Seminars in immunology 2004;16(2):119-26.
2004: Kathleen F Nolan; Victoria Strong; Dulce Soler; Paul J Fairchild; Stephen P Cobbold; Ruth Croxton; Jose-Angel Gonzalo; Ana Rubio; Meghan Wells; Herman Waldmann
IL-10-conditioned dendritic cells, decommissioned for recruitment of adaptive immunity, elicit innate inflammatory gene products in response to danger signals.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(4):2201-9.
2004: Nicolas Novitzky; Valda Thomas; Helen M Stubbings; Geoff Hale; Herman Waldmann
Radiotherapy-based conditioning is effective immunosuppression for patients undergoing transplantation with T-cell depleted stem cell grafts for severe aplasia.
Cytotherapy 2004;6(5):450-6.
2004: Nicolas Novitzky; Valda Thomas; Geoff Hale; Herman Waldmann
Campath-1 Abs 'in the bag' for hematological malignancies: the Cape Town experience.
Cytotherapy 2004;6(2):172-81.
2003: Masahide Tone; Yukiko Tone; Elizabeth Adams; Stephen F Yates; Mark R Frewin; Stephen P Cobbold; Herman Waldmann
Mouse glucocorticoid-induced tumor necrosis factor receptor ligand is costimulatory for T cells.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(25):15059-64.
2003: Stephen P Cobbold; Kathleen F Nolan; Luis Graca; Raquel Castejon; Alain Le Moine; Mark R Frewin; Susan Humm; Elizabeth Adams; Sara Thompson; Diana Zelenika; Alison Paterson; Stephen Yates; Paul J Fairchild; Herman Waldmann
Regulatory T cells and dendritic cells in transplantation tolerance: molecular markers and mechanisms.
Immunological reviews 2003;196():109-24.
2003: Luis Graca; Alain Le Moine; Stephen P Cobbold; Herman Waldmann
Dominant transplantation tolerance. Opinion.
Current opinion in immunology 2003;15(5):499-506.
2003: Paul J Fairchild; Kathleen F Nolan; Siân Cartland; Luis Graca; Herman Waldmann
Stable lines of genetically modified dendritic cells from mouse embryonic stem cells.
Transplantation 2003;76(3):606-8.
2003: Stephen P Cobbold; Elizabeth Adams; Luis Graca; Herman Waldmann
Serial analysis of gene expression provides new insights into regulatory T cells.
Seminars in immunology 2003;15(4):209-14.
2003: Herman Waldmann
The new immunosuppression.
Current opinion in chemical biology 2003;7(4):476-80.
2003: Stephen P Cobbold; Luis Graca; Chun-Yen Lin; Elizabeth Adams; Herman Waldmann
Regulatory T cells in the induction and maintenance of peripheral transplantation tolerance.
Transplant international : official journal of the European Society for Organ Transplantation 2003;16(2):66-75.
2003: Luis Graca; Alain Le Moine; Stephen P Cobbold; Herman Waldmann
Antibody-induced transplantation tolerance: the role of dominant regulation.
Immunologic research 2003;28(3):181-91.
2003: Paul J Fairchild; Kathleen F Nolan; Herman Waldmann
Probing dendritic cell function by guiding the differentiation of embryonic stem cells.
Methods in enzymology 2003;365():169-86.
2002: Nicolas Novitzky; Glenda M Davison; Geoff Hale; Herman Waldmann
Immune reconstitution at 6 months following T-cell depleted hematopoietic stem cell transplantation is predictive for treatment outcome.
Transplantation 2002;74(11):1551-9.
2002: Geoff Hale; S Slavin; J M Goldman; S Mackinnon; Sergio Giralt; Herman Waldmann
Alemtuzumab (Campath-1H) for treatment of lymphoid malignancies in the age of nonmyeloablative conditioning?
Bone marrow transplantation 2002;30(12):797-804.
2002: Chun-Yen Lin; Luis Graca; Stephen P Cobbold; Herman Waldmann
Dominant transplantation tolerance impairs CD8+ T cell function but not expansion.
Nature immunology 2002;3(12):1208-13.
2002: Julian A Symons; Elizabeth Adams; David C Tscharke; Patrick Reading; Herman Waldmann; Geoffrey L Smith
The vaccinia virus C12L protein inhibits mouse IL-18 and promotes virus virulence in the murine intranasal model.
The Journal of general virology 2002;83(Pt 11):2833-44.
2002: Jeanette Lundin; Eva Kimby; Magnus Björkholm; Per-Anders Broliden; Fredrik Celsing; Viktoria Hjalmar; Lars Möllgård; Peppy Rebello; Geoff Hale; Herman Waldmann; Håkan Mellstedt; Anders Osterborg
Phase II trial of subcutaneous anti-CD52 monoclonal antibody alemtuzumab (Campath-1H) as first-line treatment for patients with B-cell chronic lymphocytic leukemia (B-CLL).
Blood 2002;100(3):768-73.
2002: Herman Waldmann
Reprogramming the immune system.
Immunological reviews 2002;185():227-35.
2002: Luis Graca; Stephen P Cobbold; Herman Waldmann
Identification of regulatory T cells in tolerated allografts.
The Journal of experimental medicine 2002;195(12):1641-6.
2002: Luis Graca; Sara Thompson; Chun-Yen Lin; Elizabeth Adams; Stephen P Cobbold; Herman Waldmann
Both CD4(+)CD25(+) and CD4(+)CD25(-) regulatory cells mediate dominant transplantation tolerance.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(11):5558-65.
2002: Masahide Tone; Yukiko Tone; Jennifer M Babik; Chun-Yen Lin; Herman Waldmann
The role of Sp1 and NF-kappa B in regulating CD40 gene expression.
The Journal of biological chemistry 2002;277(11):8890-7.
2002: Diana Zelenika; Elizabeth Adams; Susan Humm; Luis Graca; Sara Thompson; Stephen P Cobbold; Herman Waldmann
Regulatory T cells overexpress a subset of Th2 gene transcripts.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(3):1069-79.
2001: Herman Waldmann
Therapeutic approaches for transplantation.
Current opinion in immunology 2001;13(5):606-10.
2001: Herman Waldmann; Stephen P Cobbold
Approaching tolerance in transplantation.
International archives of allergy and immunology 2001;126(1):11-22.
2001: Diana Zelenika; Elizabeth Adams; Susan Humm; C Y Lin; Herman Waldmann; Stephen P Cobbold
The role of CD4+ T-cell subsets in determining transplantation rejection or tolerance.
Immunological reviews 2001;182():164-79.
2001: Herman Waldmann; Geoff Hale; Stephen P Cobbold
Appropriate targets for monoclonal antibodies in the induction of transplantation tolerance.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2001;356(1409):659-63.
2001: Herman Waldmann; Stephen P Cobbold
Regulating the immune response to transplants. a role for CD4+ regulatory cells?
Immunity 2001;14(4):399-406.
2001: Masahide Tone; Yukiko Tone; Paul J Fairchild; Michelle Wykes; Herman Waldmann
Regulation of CD40 function by its isoforms generated through alternative splicing.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(4):1751-6.
2001: Geoff Hale; Stephen P Cobbold; Nicolas Novitzky; Donald Bunjes; R Willemze; H G Prentice; D Milligan; S MacKinnon; Herman Waldmann
CAMPATH-1 antibodies in stem-cell transplantation.
Cytotherapy 2001;3(3):145-64.
2000: Paul J Fairchild; Frances A Brook; Richard L Gardner; Luis Graca; V Strong; Yukiko Tone; Masahide Tone; Kathleen F Nolan; Herman Waldmann
Directed differentiation of dendritic cells from mouse embryonic stem cells.
Current biology : CB 2000;10(23):1515-8.
2000: Luis Graca; K Honey; Elizabeth Adams; Stephen P Cobbold; Herman Waldmann
Cutting edge: anti-CD154 therapeutic antibodies induce infectious transplantation tolerance.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(9):4783-6.
2000: Paul J Fairchild; Herman Waldmann
Dendritic cells and prospects for transplantation tolerance.
Current opinion in immunology 2000;12(5):528-35.
2000: Paul J Fairchild; Herman Waldmann
Extrathymic signals regulate the onset of T cell repertoire selection.
European journal of immunology 2000;30(7):1948-56.
2000: Geoff Hale; P Jacobs; L Wood; W E Fibbe; R Barge; Nicolas Novitzky; C Toit; Louise Abrahams; Valda Thomas; Donald Bunjes; C Duncker; Markus Wiesneth; D Selleslag; M Hidajat; M Starobinski; P Bird; Herman Waldmann
CD52 antibodies for prevention of graft-versus-host disease and graft rejection following transplantation of allogeneic peripheral blood stem cells.
Bone marrow transplantation 2000;26(1):69-76.
2000: M J Powell; SA Thompson; Yukiko Tone; Herman Waldmann; Masahide Tone
Posttranscriptional regulation of IL-10 gene expression through sequences in the 3'-untranslated region.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(1):292-6.
2000: Masahide Tone; M J Powell; Yukiko Tone; SA Thompson; Herman Waldmann
IL-10 gene expression is controlled by the transcription factors Sp1 and Sp3.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(1):286-91.
2000: K Honey; Stephen P Cobbold; Herman Waldmann
Dominant tolerance and linked suppression induced by therapeutic antibodies do not depend on Fas-FasL interactions.
Transplantation 2000;69(8):1683-9.
2000: K Honey; F Bemelman; Stephen P Cobbold; Herman Waldmann
High dose bone marrow transplantation induces deletion of antigen-specific T cells in a Fas-independent manner.
Transplantation 2000;69(8):1676-82.
2000: Glenda M Davison; Nicolas Novitzky; A Kline; Valda Thomas; Louise Abrahams; Geoff Hale; Herman Waldmann
Immune reconstitution after allogeneic bone marrow transplantation depleted of T cells.
Transplantation 2000;69(7):1341-7.
2000: Roy Y Calne; SD Moffatt; Peter J Friend; Neville V Jamieson; J Andrew Bradley; Geoff Hale; John Firth; J Bradley; Kenneth G C Smith; Herman Waldmann
Prope tolerance with induction using Campath 1H and low-dose cyclosporin monotherapy in 31 cadaveric renal allograft recipients.
Nihon Geka Gakkai zasshi 2000;101(3):301-6.
2000: Geoff Hale; Herman Waldmann
From Laboratory to Clinic : The Story of CAM PA TH-1.
Methods in molecular medicine 2000;40():243-66.
2000: Herman Waldmann
Prospects for the application of antibodies in medicine.
Methods in molecular medicine 2000;40():63-72.
2000: Andrew D Dick; P Meyer; T James; John V Forrester; Geoff Hale; Herman Waldmann; J D Isaacs
Campath-1H therapy in refractory ocular inflammatory disease.
The British journal of ophthalmology 2000;84(1):107-9.
1999: Peter J Friend; Geoff Hale; Lucienne Chatenoud; Peppy Rebello; J Bradley; Sathia Thiru; J M Phillips; Herman Waldmann
Phase I study of an engineered aglycosylated humanized CD3 antibody in renal transplant rejection.
Transplantation 1999;68(11):1632-7.
1999: Roy Y Calne; SD Moffatt; Peter J Friend; Neville V Jamieson; J Andrew Bradley; Geoff Hale; John Firth; J Bradley; Kenneth G C Smith; Herman Waldmann
Campath IH allows low-dose cyclosporine monotherapy in 31 cadaveric renal allograft recipients.
Transplantation 1999;68(10):1613-6.
1999: Peppy Rebello; Geoff Hale; Peter J Friend; Stephen P Cobbold; Herman Waldmann
Anti-globulin responses to rat and humanized CAMPATH-1 monoclonal antibody used to treat transplant rejection.
Transplantation 1999;68(9):1417-20.
1999: Alasdair J Coles; Mark G Wing; S Smith; Francesca Coraddu; S Greer; C Taylor; A Weetman; Geoff Hale; V Krishna K Chatterjee; Herman Waldmann; Alastair Compston
Pulsed monoclonal antibody treatment and autoimmune thyroid disease in multiple sclerosis.
Lancet 1999;354(9191):1691-5.
1999: K Honey; Stephen P Cobbold; Herman Waldmann
CD40 ligand blockade induces CD4+ T cell tolerance and linked suppression.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(9):4805-10.
1999: CM Lockwood; J D Elliott; Lee R Brettman; Geoff Hale; Peppy Rebello; M Frewin; Douglas J Ringler; C Merrill; Herman Waldmann
Anti-adhesion molecule therapy as an interventional strategy for autoimmune inflammation.
Clinical immunology (Orlando, Fla.) 1999;93(2):93-106.
1999: Masahide Tone; Kathleen F Nolan; LA Walsh; Yukiko Tone; SA Thompson; Herman Waldmann
Structure and chromosomal location of mouse and human CD52 genes.
Biochimica et biophysica acta 1999;1446(3):334-40.
1999: Alasdair J Coles; Mark G Wing; Paul Molyneux; A Paolillo; C M Davie; Geoff Hale; D Miller; Herman Waldmann; Alastair Compston
Monoclonal antibody treatment exposes three mechanisms underlying the clinical course of multiple sclerosis.
Annals of neurology 1999;46(3):296-304.
1999: J M Babik; Elizabeth Adams; Yukiko Tone; Paul J Fairchild; Masahide Tone; Herman Waldmann
Expression of murine IL-12 is regulated by translational control of the p35 subunit.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(7):4069-78.
1999: L K Gilliland; LA Walsh; Mark R Frewin; Matt P Wise; Masahide Tone; Geoff Hale; D Kioussis; Herman Waldmann
Elimination of the immunogenicity of therapeutic antibodies.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(6):3663-71.
1999: Nicolas Novitzky; Valda Thomas; Geoff Hale; Herman Waldmann
Ex vivo depletion of T cells from bone marrow grafts with CAMPATH-1 in acute leukemia: graft-versus-host disease and graft-versus-leukemia effect.
Transplantation 1999;67(4):620-6.
1999: Masahide Tone; Lisa E Diamond; LA Walsh; Yukiko Tone; SA Thompson; E M Shanahan; John S Logan; Herman Waldmann
High level transcription of the complement regulatory protein CD59 requires an enhancer located in intron 1.
The Journal of biological chemistry 1999;274(2):710-6.
1999: K Honey; Stephen P Cobbold; Herman Waldmann
Dominant regulation: a common mechanism of monoclonal antibody induced tolerance?
Immunologic research 1999;20(1):1-14.
1999: M Wise; Diana Zelenika; F Bemelman; Dominique Latinne; Hervé Bazin; Stephen P Cobbold; Herman Waldmann
CD4 T cells can reject major histocompatibility complex class I-incompatible skin grafts.
European journal of immunology 1999;29(1):156-67.
1998: Geoff Hale; M J Zhang; Donald Bunjes; H G Prentice; D Spence; M M Horowitz; A J Barrett; Herman Waldmann
Improving the outcome of bone marrow transplantation by using CD52 monoclonal antibodies to prevent graft-versus-host disease and graft rejection.
Blood 1998;92(12):4581-90.
1998: Matt P Wise; F Bemelman; Stephen P Cobbold; Herman Waldmann
Linked suppression of skin graft rejection can operate through indirect recognition.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(11):5813-6.
1998: J D Isaacs; J Greenwood; Herman Waldmann
Therapy with monoclonal antibodies. II. The contribution of Fc gamma receptor binding and the influence of C(H)1 and C(H)3 domains on in vivo effector function.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(8):3862-9.
1998: Stephen P Cobbold; Herman Waldmann
Infectious tolerance.
Current opinion in immunology 1998;10(5):518-24.
1998: Diana Zelenika; Elizabeth Adams; Andrew L Mellor; E Simpson; Phillip R Chandler; B Stockinger; Herman Waldmann; Stephen P Cobbold
Rejection of H-Y disparate skin grafts by monospecific CD4+ Th1 and Th2 cells: no requirement for CD8+ T cells or B cells.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(4):1868-74.
1998: Kathleen F Nolan; David Greaves; Herman Waldmann
The human interleukin 18 gene IL18 maps to 11q22.2-q22.3, closely linked to the DRD2 gene locus and distinct from mapped IDDM loci.
Genomics 1998;51(1):161-3.
1998: Roy Y Calne; Peter J Friend; SD Moffatt; A Bradley; Geoff Hale; John Firth; J Bradley; K Smith; Herman Waldmann
Prope tolerance, perioperative campath 1H, and low-dose cyclosporin monotherapy in renal allograft recipients.
Lancet 1998;351(9117):1701-2.
1998: Andrew D Dick; Linda Duncan; Geoff Hale; Herman Waldmann; J Isaacs
Neutralizing TNF-alpha activity modulates T-cell phenotype and function in experimental autoimmune uveoretinitis.
Journal of autoimmunity 1998;11(3):255-64.
1998: Geoff Hale; Herman Waldmann
Risks of developing Epstein-Barr virus-related lymphoproliferative disorders after T-cell-depleted marrow transplants. CAMPATH Users.
Blood 1998;91(8):3079-83.
1998: F Bemelman; K Honey; Elizabeth Adams; Stephen P Cobbold; Herman Waldmann
Bone marrow transplantation induces either clonal deletion or infectious tolerance depending on the dose.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(6):2645-8.
1998: J D Elliott; CM Lockwood; Geoff Hale; Herman Waldmann
Semi-specific immuno-absorption and monoclonal antibody therapy in ANCA positive vasculitis: experience in four cases.
Autoimmunity 1998;28(3):163-71.
1998: Herman Waldmann; F Bemelman; Stephen P Cobbold
Tolerance induction with CD4 monoclonal antibodies.
Novartis Foundation symposium 1998;215():146-52; discussion 152-8, 186-90.
1998: Herman Waldmann; Stephen P Cobbold
How do monoclonal antibodies induce tolerance? A role for infectious tolerance?
Annual review of immunology 1998;16():619-44.
1997: Masahide Tone; SA Thompson; Yukiko Tone; Paul J Fairchild; Herman Waldmann
Regulation of IL-18 (IFN-gamma-inducing factor) gene expression.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(12):6156-63.
1997: J D Isaacs; Nigel P Burrows; M Wing; M T Keogan; Peppy Rebello; Richard Watts; R J Pye; P Norris; B L Hazelman; Geoff Hale; Herman Waldmann
Humanized anti-CD4 monoclonal antibody therapy of autoimmune and inflammatory disease.
Clinical and experimental immunology 1997;110(2):158-66.
1997: Ralph Scully; Stephen P Cobbold; Andrew L Mellor; Karl Martin Wissing; B Arnold; Herman Waldmann
A role for Th2 cytokines in the suppression of CD8+ T cell-mediated graft rejection.
European journal of immunology 1997;27(7):1663-70.
1997: J D Davies; Stephen P Cobbold; Herman Waldmann
Strain variation in susceptibility to monoclonal antibody-induced transplantation tolerance.
Transplantation 1997;63(11):1570-3.
1996: Mark G Wing; T Moreau; J Greenwood; R M Smith; Geoff Hale; J Isaacs; Herman Waldmann; Peter Lachmann; Alastair Compston
Mechanism of first-dose cytokine-release syndrome by CAMPATH 1-H: involvement of CD16 (FcgammaRIII) and CD11a/CD18 (LFA-1) on NK cells.
The Journal of clinical investigation 1996;98(12):2819-26.
1996: S E Marshall; Stephen P Cobbold; J D Davies; G M Martin; J M Phillips; Herman Waldmann
Tolerance and suppression in a primed immune system.
Transplantation 1996;62(11):1614-21.
1996: CM Lockwood; Sathia Thiru; S Stewart; Geoff Hale; J Isaacs; P Wraight; J Elliott; Herman Waldmann
Treatment of refractory Wegener's granulomatosis with humanized monoclonal antibodies.
QJM : monthly journal of the Association of Physicians 1996;89(12):903-12.
1996: J D Isaacs; Mark G Wing; J D Greenwood; B L Hazleman; Geoff Hale; Herman Waldmann
A therapeutic human IgG4 monoclonal antibody that depletes target cells in humans.
Clinical and experimental immunology 1996;106(3):427-33.
1996: ZK Chen; Stephen P Cobbold; Herman Waldmann; Su M Metcalfe
Amplification of natural regulatory immune mechanisms for transplantation tolerance.
Transplantation 1996;62(9):1200-6.
1996: J D Davies; G Martin; J Phillips; S E Marshall; Stephen P Cobbold; Herman Waldmann
T cell regulation in adult transplantation tolerance.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(2):529-33.
1996: T Moreau; Alasdair J Coles; Mark G Wing; J Thorpe; D Miller; I Moseley; J Issacs; Geoff Hale; David Clayton; N Scolding; Herman Waldmann; Alastair Compston
CAMPATH-IH in multiple sclerosis.
Multiple sclerosis (Houndmills, Basingstoke, England) 1996;1(6):357-65.
1996: Yukiko Tone; SA Thompson; J M Babik; Kathleen F Nolan; Masahide Tone; C Raven; Herman Waldmann
Structure and chromosomal location of the mouse interleukin-12 p35 and p40 subunit genes.
European journal of immunology 1996;26(6):1222-7.
1996: J D Davies; L Y Leong; Andrew L Mellor; Stephen P Cobbold; Herman Waldmann
T cell suppression in transplantation tolerance through linked recognition.
Journal of immunology (Baltimore, Md. : 1950) 1996;156(10):3602-7.
1996: Geoff Hale; Herman Waldmann
Recent results using CAMPATH-1 antibodies to control GVHD and graft rejection.
Bone marrow transplantation 1996;17(3):305-8.
1996: Stephen P Cobbold; E Adams; S E Marshall; J D Davies; Herman Waldmann
Mechanisms of peripheral tolerance and suppression induced by monoclonal antibodies to CD4 and CD8.
Immunological reviews 1996;149():5-33.
1996: T Moreau; Alasdair J Coles; Mark G Wing; J Isaacs; Geoff Hale; Herman Waldmann; Alastair Compston
Transient increase in symptoms associated with cytokine release in patients with multiple sclerosis.
Brain : a journal of neurology 1996;119 ( Pt 1)():225-37.
1995: Lisa E Diamond; K R McCurry; E R Oldham; Masahide Tone; Herman Waldmann; Jeffrey L Platt; John S Logan
Human CD59 expressed in transgenic mouse hearts inhibits the activation of complement.
Transplant immunology 1995;3(4):305-12.
1995: I G Brons; H S Davies; C J Watson; Stephen P Cobbold; Herman Waldmann; Roy Y Calne
Substantial peripheral T-cell depletion before grafting is beneficial in islet transplantation.
Transplantation proceedings 1995;27(6):3181.
1995: E G Routledge; M E Falconer; H Pope; I S Lloyd; Herman Waldmann
The effect of aglycosylation on the immunogenicity of a humanized therapeutic CD3 monoclonal antibody.
Transplantation 1995;60(8):847-53.
1995: Mark G Wing; Herman Waldmann; J Isaacs; D A S Compston; Geoff Hale
Ex-vivo whole blood cultures for predicting cytokine-release syndrome: dependence on target antigen and antibody isotype.
Therapeutic immunology 1995;2(4):183-90.
1995: D L Kooyman; Guerard W Byrne; S McClellan; D Nielsen; Masahide Tone; Herman Waldmann; T M Coffman; K R McCurry; Jeffrey L Platt; John S Logan
In vivo transfer of GPI-linked complement restriction factors from erythrocytes to the endothelium.
Science (New York, N.Y.) 1995;269(5220):89-92.
1995: C J Watson; H F Davies; Stephen P Cobbold; A Rasmussen; Peppy Rebello; Sathia Thiru; Herman Waldmann; Roy Y Calne; Su M Metcalfe
CD4 and CD8 monoclonal antibody therapy in the dog: strategies to induce tolerance to renal allografts.
Transplantation proceedings 1995;27(1):123-4.
1995: I G Brons; H F Davies; A Rasmussen; C J Watson; Sathia Thiru; Stephen P Cobbold; Herman Waldmann; Roy Y Calne
Islet allografting in the dog model: potential therapies for tolerance induction.
Transplantation proceedings 1995;27(1):609-10.
1995: D K Newman; J D Isaacs; P G Watson; P A Meyer; Geoff Hale; Herman Waldmann
Prevention of immune-mediated corneal graft destruction with the anti-lymphocyte monoclonal antibody, CAMPATH-1H.
Eye (London, England) 1995;9 ( Pt 5)():564-9.
1994: Ralph Scully; S Qin; S Cobbold; Herman Waldmann
Mechanisms in CD4 antibody-mediated transplantation tolerance: kinetics of induction, antigen dependency and role of regulatory T cells.
European journal of immunology 1994;24(10):2383-92.
1994: Herman Waldmann; S Cobbold; G Hale
What can be done to prevent graft versus host disease?
Current opinion in immunology 1994;6(5):777-83.
1994: J Greenwood; S D Gorman; E G Routledge; I S Lloyd; Herman Waldmann
Engineering multiple-domain forms of the therapeutic antibody CAMPATH-1H: effects on complement lysis.
Therapeutic immunology 1994;1(5):247-55.
1994: Z Chen; S Cobbold; Herman Waldmann; Su M Metcalfe
Combined use of RS61443 with CD4 and CD8 MAbs to generate tolerance to skin xenografts from rat to mouse.
Transplantation proceedings 1994;26(4):2433-4.
1994: H S Davies; Stephen P Cobbold; C J Watson; Su M Metcalfe; Peppy Rebello; Sathia Thiru; R McNair; A Rasmussen; Herman Waldmann; Roy Y Calne
Production, selection, and testing of monoclonal antibodies to canine leukocytes in the dog kidney allograft model.
Transplantation proceedings 1994;26(4):1941-2.
1994: T Moreau; J Thorpe; D Miller; I Moseley; Geoff Hale; Herman Waldmann; David Clayton; Mark G Wing; Neil Scolding; Alastair Compston
Preliminary evidence from magnetic resonance imaging for reduction in disease activity after lymphocyte depletion in multiple sclerosis.
Lancet 1994;344(8918):298-301.
1994: Z Chen; Stephen P Cobbold; Herman Waldmann; Su M Metcalfe
Tolerance induction in concordant heart-xenografted mice by CD4 and CD8 monoclonal antibodies.
Transplantation proceedings 1994;26(3):1199-200.
1994: D Kooyman; G Byrne; S McClellan; D Nielsen; D Kagan; T Coffman; T Masahide; Herman Waldmann; Jeffrey L Platt; J Logan
Erythroid-specific expression of human CD59 and transfer to vascular endothelial cells.
Transplantation proceedings 1994;26(3):1241.
1994: Lisa E Diamond; E R Oldham; Jeffrey L Platt; Herman Waldmann; Masahide Tone; L A Walsh; John S Logan
Cell- and tissue-specific expression of a human CD59 minigene in transgenic mice.
Transplantation proceedings 1994;26(3):1239.
1994: Geoff Hale; Herman Waldmann
Control of graft-versus-host disease and graft rejection by T cell depletion of donor and recipient with Campath-1 antibodies. Results of matched sibling transplants for malignant diseases.
Bone marrow transplantation 1994;13(5):597-611.
1994: I G Brons; H S Davies; H Makisalo; A Rasmussen; Stephen P Cobbold; Herman Waldmann; Roy Y Calne
Transplantation of immunomodulated dog islets.
Transplantation proceedings 1994;26(2):754.
1994: S D Gorman; M R Frewin; Stephen P Cobbold; Herman Waldmann
Isolation and expression of cDNA encoding the canine CD4 and CD8 alpha antigens.
Tissue antigens 1994;43(3):184-8.
1994: C J Watson; Stephen P Cobbold; H S Davies; Peppy Rebello; Sathia Thiru; R McNair; A Rasmussen; Herman Waldmann; Roy Y Calne; Su M Metcalfe
Immunosuppression of canine renal allograft recipients by CD4 and CD8 monoclonal antibodies.
Tissue antigens 1994;43(3):155-62.
1994: C J Watson; Stephen P Cobbold; H F Davies; Peppy Rebello; Herman Waldmann; Roy Y Calne; Su M Metcalfe
CD4 and CD8 monoclonal antibody therapy in canine renal allografts.
Transplant international : official journal of the European Society for Organ Transplantation 1994;7 Suppl 1():S322-4.
1994: G Hale; Herman Waldmann
CAMPATH-1 monoclonal antibodies in bone marrow transplantation.
Journal of hematotherapy 1994;3(1):15-31.
1993: Nicole Parish; Patricia Hutchings; Herman Waldmann; Anne Cooke
Tolerance to IDDM induced by CD4 antibodies in nonobese diabetic mice is reversed by cyclophosphamide.
Diabetes 1993;42(11):1601-5.
1993: C J Watson; Stephen P Cobbold; H S Davies; Peppy Rebello; Herman Waldmann; Roy Y Calne; Su M Metcalfe
CD4 and CD8 monoclonal antibody therapy: strategies to prolong renal allograft survival in the dog.
The British journal of surgery 1993;80(11):1389-92.
1993: Herman Waldmann; S Cobbold
Monoclonal antibodies for the induction of transplantation tolerance.
Current opinion in immunology 1993;5(5):753-8.
1993: MengQi Xia; Geoff Hale; Herman Waldmann
Efficient complement-mediated lysis of cells containing the CAMPATH-1 (CDw52) antigen.
Molecular immunology 1993;30(12):1089-96.
1993: MengQi Xia; Geoff Hale; M R Lifely; M A Ferguson; D Campbell; Len C Packman; Herman Waldmann
Structure of the CAMPATH-1 antigen, a glycosylphosphatidylinositol-anchored glycoprotein which is an exceptionally good target for complement lysis.
The Biochemical journal 1993;293 ( Pt 3)():633-40.
1993: CM Lockwood; Sathia Thiru; J D Isaacs; Geoff Hale; Herman Waldmann
Long-term remission of intractable systemic vasculitis with monoclonal antibody therapy.
Lancet 1993;341(8861):1620-2.
1993: J Greenwood; M Clark; Herman Waldmann
Structural motifs involved in human IgG antibody effector functions.
European journal of immunology 1993;23(5):1098-104.
1993: Richard Watts; J D Isaacs; Geoff Hale; B L Hazleman; Herman Waldmann
CAMPATH-1H in inflammatory arthritis.
Clinical and experimental rheumatology 1993;11 Suppl 8():S165-7.
1993: Herman Waldmann; Stephen P Cobbold; J Isaacs; Geoff Hale; B Hazleman; A Cooke; M Lockwood
Reprogramming the immune system: a possible therapeutic approach to established autoimmune disease.
Clinical and experimental rheumatology 1993;11 Suppl 8():S137.
1993: S Qin; Stephen P Cobbold; H Pope; J Elliott; D Kioussis; J Davies; Herman Waldmann
"Infectious" transplantation tolerance.
Science (New York, N.Y.) 1993;259(5097):974-7.
1993: C J Watson; H S Davies; Su M Metcalfe; Stephen P Cobbold; Peppy Rebello; D S Collier; Herman Waldmann; Roy Y Calne
CD4 monoclonal antibodies in the preclinical dog renal allograft model.
Transplantation proceedings 1993;25(1 Pt 1):804-6.
1993: Z Chen; S Cobbold; Herman Waldmann; Su M Metcalfe
Stability of tolerance in mice generated by CD4 and CD8 monoclonal antibody treatment: cell transfer experiments.
Transplantation proceedings 1993;25(1 Pt 1):790-1.
1993: S Bolt; E Routledge; I Lloyd; L Chatenoud; H Pope; S D Gorman; M Clark; Herman Waldmann
The generation of a humanized, non-mitogenic CD3 monoclonal antibody which retains in vitro immunosuppressive properties.
European journal of immunology 1993;23(2):403-11.
1993: Herman Waldmann; S Qin; Stephen P Cobbold
Monoclonal antibodies for the therapeutic induction of tolerance.
Immunology series 1993;59():85-99.
1992: Herman Waldmann; Stephen P Cobbold; D Wraith; J Isaacs
Therapeutic immunosuppression of T cells.
Current opinion in biotechnology 1992;3(6):668-74.
1992: L Y Leong; S Qin; Stephen P Cobbold; Herman Waldmann
Classical transplantation tolerance in the adult: the interaction between myeloablation and immunosuppression.
European journal of immunology 1992;22(11):2825-30.
1992: L A Walsh; Masahide Tone; Sathia Thiru; Herman Waldmann
The CD59 antigen--a multifunctional molecule.
Tissue antigens 1992;40(5):213-20.
1992: Masahide Tone; L A Walsh; Herman Waldmann
Gene structure of human CD59 and demonstration that discrete mRNAs are generated by alternative polyadenylation.
Journal of molecular biology 1992;227(3):971-6.
1992: Stephen P Cobbold; S Qin; L Y Leong; G Martin; Herman Waldmann
Reprogramming the immune system for peripheral tolerance with CD4 and CD8 monoclonal antibodies.
Immunological reviews 1992;129():165-201.
1992: J D Isaacs; Richard Watts; B L Hazleman; Geoff Hale; M T Keogan; S P Cobbold; Herman Waldmann
Humanised monoclonal antibody therapy for rheumatoid arthritis.
Lancet 1992;340(8822):748-52.
1992: Patricia Hutchings; L O'Reilly; Nicole Parish; Herman Waldmann; Anne Cooke
The use of a non-depleting anti-CD4 monoclonal antibody to re-establish tolerance to beta cells in NOD mice.
European journal of immunology 1992;22(7):1913-8.
1992: I G Brons; P F Tavora; Stephen P Cobbold; H S Davies; Herman Waldmann; Roy Y Calne
Synergistic monoclonal antibodies for in vitro immunomodulation of dog islets.
Transplantation proceedings 1992;24(3):1032-3.
1992: J D Isaacs; Michael R Clark; J Greenwood; Herman Waldmann
Therapy with monoclonal antibodies. An in vivo model for the assessment of therapeutic potential.
Journal of immunology (Baltimore, Md. : 1950) 1992;148(10):3062-71.
1992: Z Chen; S Cobbold; Su M Metcalfe; Herman Waldmann
Tolerance in the mouse to major histocompatibility complex-mismatched heart allografts, and to rat heart xenografts, using monoclonal antibodies to CD4 and CD8.
European journal of immunology 1992;22(3):805-10.
1992: I G Brons; R Champeney; Stephen P Cobbold; H S Davies; Herman Waldmann; Roy Y Calne
Immunomodulation of dog islets using a cocktail of monoclonal antibodies.
Transplant international : official journal of the European Society for Organ Transplantation 1992;5 Suppl 1():S484-6.
1991: E G Routledge; I Lloyd; S D Gorman; M Clark; Herman Waldmann
A humanized monovalent CD3 antibody which can activate homologous complement.
European journal of immunology 1991;21(11):2717-25.
1991: Peter J Friend; Herman Waldmann; Geoff Hale; S Cobbold; Peppy Rebello; Sathia Thiru; Neville V Jamieson; P S Johnston; Roy Y Calne
Reversal of allograft rejection using the monoclonal antibody, Campath-1G.
Transplantation proceedings 1991;23(4):2253-4.
1991: MengQi Xia; Masahide Tone; Len C Packman; Geoff Hale; Herman Waldmann
Characterization of the CAMPATH-1 (CDw52) antigen: biochemical analysis and cDNA cloning reveal an unusually small peptide backbone.
European journal of immunology 1991;21(7):1677-84.
1991: S D Gorman; Michael R Clark; E G Routledge; Stephen P Cobbold; Herman Waldmann
Reshaping a therapeutic CD4 antibody.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(10):4181-5.
1991: L A Walsh; Masahide Tone; Herman Waldmann
Transfection of human CD59 complementary DNA into rat cells confers resistance to human complement.
European journal of immunology 1991;21(3):847-50.
1991: Peter J Friend; Herman Waldmann; S Cobbold; H Tighe; Peppy Rebello; D G D Wight; S Gore; S Pollard; S Lim; P Johnston
The anti-IL-2 receptor monoclonal antibody YTH-906 in liver transplantation.
Transplantation proceedings 1991;23(1 Pt 2):1390-2.
1991: A M Varey; Patricia Hutchings; L O'Reilly; T Hussell; Herman Waldmann; Elizabeth Simpson; Anne Cooke
The development of insulin-dependent diabetes mellitus in non-obese diabetic mice: the role of CD4+ and CD8+ T cells.
Biochemical Society transactions 1991;19(1):187-91.
1990: Stephen P Cobbold; G Martin; Herman Waldmann
The induction of skin graft tolerance in major histocompatibility complex-mismatched or primed recipients: primed T cells can be tolerized in the periphery with anti-CD4 and anti-CD8 antibodies.
European journal of immunology 1990;20(12):2747-55.
1990: S X Qin; M Wise; Stephen P Cobbold; L Leong; Yi chi M Kong; J R Parnes; Herman Waldmann
Induction of tolerance in peripheral T cells with monoclonal antibodies.
European journal of immunology 1990;20(12):2737-45.
1990: Stephen P Cobbold; S X Qin; Herman Waldmann
Reprogramming the immune system for tolerance with monoclonal antibodies.
Seminars in immunology 1990;2(6):377-87.
1990: S Meri; B P Morgan; A Davies; R H Daniels; M G Olavesen; Herman Waldmann; Peter Lachmann
Human protectin (CD59), an 18,000-20,000 MW complement lysis restricting factor, inhibits C5b-8 catalysed insertion of C9 into lipid bilayers.
Immunology 1990;71(1):1-9.
1990: Peter W Mathieson; Stephen P Cobbold; Geoff Hale; M R Clark; D B G Oliveira; CM Lockwood; Herman Waldmann
Monoclonal-antibody therapy in systemic vasculitis.
The New England journal of medicine 1990;323(4):250-4.
1990: Patricia Hutchings; Elizabeth Simpson; L A O'Reilly; T Lund; Herman Waldmann; Anne Cooke
The involvement of Ly2+ T cells in beta cell destruction.
Journal of autoimmunity 1990;3 Suppl 1():101-9.
1990: Geoff Hale; MengQi Xia; H P Tighe; M J Dyer; Herman Waldmann
The CAMPATH-1 antigen (CDw52).
Tissue antigens 1990;35(3):118-27.
1990: C I Bindon; Geoff Hale; Herman Waldmann
Complement activation by immunoglobulin does not depend solely on C1q binding.
European journal of immunology 1990;20(2):277-81.
1990: S P Cobbold; G Hale; M R Clark; Herman Waldmann
Purging in auto- and allografts: monoclonal antibodies which use human complement and other natural effector mechanisms.
Progress in clinical and biological research 1990;333():139-51; discussion 152-4.
1989: Marianne Brüggemann; G Winter; Herman Waldmann; Michael S Neuberger
The immunogenicity of chimeric antibodies.
The Journal of experimental medicine 1989;170(6):2153-7.
1989: Marianne Brüggemann; H M Caskey; C Teale; Herman Waldmann; Gareth T Williams; M A Surani; Michael S Neuberger
A repertoire of monoclonal antibodies with human heavy chains from transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(17):6709-13.
1989: Peter J Friend; Geoff Hale; Herman Waldmann; S Gore; Sathia Thiru; V Joysey; D B Evans; Roy Y Calne
Campath-1M--prophylactic use after kidney transplantation. A randomized controlled clinical trial.
Transplantation 1989;48(2):248-53.
1989: Martin J S Dyer; Geoff Hale; F G Hayhoe; Herman Waldmann
Effects of CAMPATH-1 antibodies in vivo in patients with lymphoid malignancies: influence of antibody isotype.
Blood 1989;73(6):1431-9.
1989: Marianne Brüggemann; C Teale; M Clark; C Bindon; Herman Waldmann
A matched set of rat/mouse chimeric antibodies. Identification and biological properties of rat H chain constant regions mu, gamma 1, gamma 2a, gamma 2b, gamma 2c, epsilon, and alpha.
Journal of immunology (Baltimore, Md. : 1950) 1989;142(9):3145-50.
1989: S X Qin; S Cobbold; R Benjamin; Herman Waldmann
Induction of classical transplantation tolerance in the adult.
The Journal of experimental medicine 1989;169(3):779-94.
1989: M Clark; C Bindon; M Dyer; Peter J Friend; Geoff Hale; S Cobbold; Roy Y Calne; Herman Waldmann
The improved lytic function and in vivo efficacy of monovalent monoclonal CD3 antibodies.
European journal of immunology 1989;19(2):381-8.
1989: R Zamoyska; Herman Waldmann; Polly Matzinger
Peripheral tolerance mechanisms prevent the development of autoreactive T cells in chimeras grafted with two minor incompatible thymuses.
European journal of immunology 1989;19(1):111-7.
1989: Herman Waldmann; Stephen P Cobbold; S Qin; R J Benjamin; M Wise
Tolerance induction in the adult using monoclonal antibodies to CD4, CD8, and CD11a (LFA-1).
Cold Spring Harbor symposia on quantitative biology 1989;54 Pt 2():885-92.
1989: Herman Waldmann
Manipulation of T-cell responses with monoclonal antibodies.
Annual review of immunology 1989;7():407-44.
1988: Geoff Hale; M J Dyer; M R Clark; J M Phillips; R Marcus; L Riechmann; G Winter; Herman Waldmann
Remission induction in non-Hodgkin lymphoma with reshaped human monoclonal antibody CAMPATH-1H.
Lancet 1988;2(8625):1394-9.
1988: Herman Waldmann
Immunosuppression with monoclonal antibodies: some speculations about tolerance in the context of tissue grafting.
Transplantation proceedings 1988;20(6 Suppl 8):46-52.
1988: L K Gilliland; Michael R Clark; Herman Waldmann
Universal bispecific antibody for targeting tumor cells for destruction by cytotoxic T cells.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(20):7719-23.
1988: C I Bindon; Geoff Hale; Herman Waldmann
Importance of antigen specificity for complement-mediated lysis by monoclonal antibodies.
European journal of immunology 1988;18(10):1507-14.
1988: C I Bindon; Geoff Hale; Marianne Brüggemann; Herman Waldmann
Human monoclonal IgG isotypes differ in complement activating function at the level of C4 as well as C1q.
The Journal of experimental medicine 1988;168(1):127-42.
1988: R J Benjamin; S X Qin; Matt P Wise; Stephen P Cobbold; Herman Waldmann
Mechanisms of monoclonal antibody-facilitated tolerance induction: a possible role for the CD4 (L3T4) and CD11a (LFA-1) molecules in self-non-self discrimination.
European journal of immunology 1988;18(7):1079-88.
1988: Geoff Hale; S Cobbold; Herman Waldmann
T cell depletion with CAMPATH-1 in allogeneic bone marrow transplantation.
Transplantation 1988;45(4):753-9.
1988: Marianne Brüggemann; P Delmastro-Galfrè; Herman Waldmann; F Calabi
Sequence of a rat immunoglobulin gamma 2c heavy chain constant region cDNA: extensive homology to mouse gamma 3.
European journal of immunology 1988;18(2):317-9.
1988: M Clark; L Gilliland; Herman Waldmann
The potential of hybrid antibodies secreted by hybrid-hybridomas in tumour therapy.
International journal of cancer. Supplement = Journal international du cancer. Supplement 1988;2():15-7.
1988: H Tighe; Peter J Friend; S J Collier; M Decurtins; S Lim; Stephen P Cobbold; Sathia Thiru; Roy Y Calne; Herman Waldmann
Delayed allograft rejection in primates treated with anti-IL-2 receptor monoclonal antibody Campath-6.
Transplantation 1988;45(1):226-8.
1987: Michael R Clark; Herman Waldmann
T-cell killing of target cells induced by hybrid antibodies: comparison of two bispecific monoclonal antibodies.
Journal of the National Cancer Institute 1987;79(6):1393-401.
1987: H Tighe; M Clark; Herman Waldmann
Blocking of cytotoxic T cell function by monoclonal antibodies against the CD45 antigen (T200/leukocyte-common antigen).
Transplantation 1987;44(6):818-23.
1987: Marianne Brüggemann; G T Williams; C I Bindon; M R Clark; M R Walker; Roy Jefferis; Herman Waldmann; Michael S Neuberger
Comparison of the effector functions of human immunoglobulins using a matched set of chimeric antibodies.
The Journal of experimental medicine 1987;166(5):1351-61.
1987: Geoff Hale; Stephen P Cobbold; Herman Waldmann; G Easter; P Matejtschuk; R R Coombs
Isolation of low-frequency class-switch variants from rat hybrid myelomas.
Journal of immunological methods 1987;103(1):59-67.
1987: Peter J Friend; H Tighe; S Lim; D S Collier; M Decurtins; L K Gilliland; Sathia Thiru; Roy Y Calne; Herman Waldmann
The use of monoclonal antibodies against activated human T cells following renal allografting in the baboon.
Transplantation proceedings 1987;19(5):4317-8.
1987: S Qin; S Cobbold; H Tighe; R Benjamin; Herman Waldmann
CD4 monoclonal antibody pairs for immunosuppression and tolerance induction.
European journal of immunology 1987;17(8):1159-65.
1987: C I Bindon; Geoff Hale; N Hughes-Jones; B Gorick; Herman Waldmann
Synergistic complement lysis by monoclonal antibodies to the human leukocyte common antigen requires both the classical and alternative pathways.
Molecular immunology 1987;24(6):587-94.
1987: Peter J Friend; Roy Y Calne; Geoff Hale; Herman Waldmann; D B Evans; K Rolles; Sathia Thiru; S Gore
Prophylactic use of an antilymphocyte monoclonal antibody following renal transplantation: a randomized controlled trial.
Transplantation proceedings 1987;19(1 Pt 3):1898-900.
1987: Herman Waldmann; S Cobbold; S Qin; R Benjamin; T Nash; J Welsh; G Tarnesby
Monoclonal antibodies for the depletion of specific subpopulations of lymphocytes.
Ciba Foundation symposium 1987;129():194-208.
1986: Geoff Hale; Herman Waldmann; Peter J Friend; Roy Y Calne
Pilot study of CAMPATH-1, a rat monoclonal antibody that fixes human complement, as an immunosuppressant in organ transplantation.
Transplantation 1986;42(3):308-11.
1986: R J Benjamin; Stephen P Cobbold; M R Clark; Herman Waldmann
Tolerance to rat monoclonal antibodies. Implications for serotherapy.
The Journal of experimental medicine 1986;163(6):1539-52.
1984: Polly Matzinger; R Zamoyska; Herman Waldmann
Self tolerance is H-2-restricted.
Nature 1984;308(5961):738-41.
1983: T Hoang; D Gilmore; D Metcalf; S Cobbold; S Watt; M Clark; M Furth; Herman Waldmann
Separation of hemopoietic cells from adult mouse marrow by use of monoclonal antibodies.
Blood 1983;61(3):580-8.