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Bruce Walker

Research Profile

Living Beings

HIV-1
HIV

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Anatomy

Genes & Molecular Sequences

Amino Acid Sequences

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CD4 Lymphocyte Count

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Publications

TOP 3
Zaza M Ndhlovu; Florencia Pereyra; Alicja Piechocka-Trocha; Filippos Porichis; Jacqueline Proudfoot; Eleni Stampouloglou; Seanna Vine; Bruce D Walker; Donna Marie Alvino; Kevin Cesa; Lori B Chibnik; Philip L De Jager; Meghan G Hart; David Heckerman; R Brad Jones; Carl Kadie; Ashley McMullen; Daniel E Kaufmann
High-dimensional immunomonitoring models of HIV-1-specific CD8 T-cell responses accurately identify subjects achieving spontaneous viral control.
Henrik N Kløverpris; Alasdair J Leslie; Thumbi Ndung'u; Lynn Riddell; Dewald Steyn; Mary van der Stok; Cloete van Vuuren; Bruce D Walker; Søren Buus; Jonathan M Carlson; Mary Carrington; Fabian Chen; John Frater; Dominique Goedhals; Mikkel Harndahl; Kuan-Hsiang Gary Huang; Nasreen Ismail; Philip J R Goulder
HIV control through a single nucleotide on the HLA-B locus.
Philip J R Goulder; Bruce D Walker
HIV and HLA class I: an evolving relationship.

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All Publications

2013: Zaza M Ndhlovu; Florencia Pereyra; Alicja Piechocka-Trocha; Filippos Porichis; Jacqueline Proudfoot; Eleni Stampouloglou; Seanna Vine; Bruce D Walker; Donna Marie Alvino; Kevin Cesa; Lori B Chibnik; Philip L De Jager; Meghan G Hart; David Heckerman; R Brad Jones; Carl Kadie; Ashley McMullen; Daniel E Kaufmann
High-dimensional immunomonitoring models of HIV-1-specific CD8 T-cell responses accurately identify subjects achieving spontaneous viral control.
Blood 2013;121(5):801-11.
2012: Henrik N Kløverpris; Alasdair J Leslie; Thumbi Ndung'u; Lynn Riddell; Dewald Steyn; Mary van der Stok; Cloete van Vuuren; Bruce D Walker; Søren Buus; Jonathan M Carlson; Mary Carrington; Fabian Chen; John Frater; Dominique Goedhals; Mikkel Harndahl; Kuan-Hsiang Gary Huang; Nasreen Ismail; Philip J R Goulder
HIV control through a single nucleotide on the HLA-B locus.
Journal of virology 2012;86(21):11493-500.
2012: Philip J R Goulder; Bruce D Walker
HIV and HLA class I: an evolving relationship.
Immunity 2012;37(3):426-40.
2012: Mathieu Angin; Melanie King; Florencia Pereyra; Hendrik Streeck; Bruce D Walker; Fang Wen; Marcus Altfeld; Marylyn M Addo
Regulatory T cell frequencies do not correlate with breadth or magnitude of HIV-1-specific T cell responses.
AIDS research and human retroviruses 2012;28(8):749-51.
2012: Florian Klein; Zane Kraft; Clara Lehmann; Yan Liu; Lynn Morris; Hugo Mouquet; Gerd Fätkenheuer; Ten Feizi; Christian Gaebler; Arlene Hurley; John Pietzsch; Pascal Poignard; D Noah Sather; Johannes F Scheid; Michael S Seaman; Leonidas Stamatatos; Bruce D Walker; Michel C Nussenzweig
Broad neutralization by a combination of antibodies recognizing the CD4 binding site and a new conformational epitope on the HIV-1 envelope protein.
The Journal of experimental medicine 2012;209(8):1469-79.
2012: Shao Chong Zhang; Paul Liebesny; Shirley Locastro; Eric Martin; Oluwatobi Awele Ogbechie; Mariko Shimada; Bruce D Walker; Chanson J Brumme; Zabrina L Brumme; Jonathan M Carlson; Huabiao Chen; Jennifer Fricke; Sasha Blue Godfrey; Daniel G Kavanagh; Nicole Y Lai; Sylvie Le Gall
Aminopeptidase substrate preference affects HIV epitope presentation and predicts immune escape patterns in HIV-infected individuals.
Journal of immunology (Baltimore, Md. : 1950) 2012;188(12):5924-34.
2012: Zaza M Ndhlovu; Donna Marie Alvino; Kevin Cesa; Ashley McMullen; Alicja Piechocka-Trocha; Jacqueline Proudfoot; Eleni Stampouloglou; Seanna Vine; Bruce D Walker; Florencia Pereyra
Elite controllers with low to absent effector CD8+ T cell responses maintain highly functional, broadly directed central memory responses.
Journal of virology 2012;86(12):6959-69.
2012: Christina Thobakgale; Ildiko Toth; Bruce D Walker; Todd M Allen; Galit Alter; Suzane Bazner; Mary Carrington; Lena Fadda; Kimberly Lane; Thumbi Ndung'u; Florencia Pereyra; Eric S Rosenberg; Marcus Altfeld
Frequent and strong antibody-mediated natural killer cell activation in response to HIV-1 Env in individuals with chronic HIV-1 infection.
Journal of virology 2012;86(12):6986-93.
2012: Jonathan M Carlson; John Frater; Philip J R Goulder; Carl Kadie; Jennifer Listgarten; Thumbi Ndung'u; Nico Pfeifer; Roger Shapiro; Vincent Tan; Bruce D Walker; Zabrina L Brumme; David Heckerman
Widespread impact of HLA restriction on immune control and escape pathways of HIV-1.
Journal of virology 2012;86(9):5230-43.
2012: Navin Varadarajan; Bruce D Walker; Adebola O Ogunniyi; James M Richter; Melis N Anahtar; Douglas S Kwon; Kenneth M Law; J Christopher Love
Rapid, efficient functional characterization and recovery of HIV-specific human CD8+ T cells using microengraving.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(10):3885-90.
2012: Damien Z Soghoian; Bruce D Walker; Abraham L Brass; Jason M Brenchley; Sam Cutler; Isaiah Davis; Michael Flanders; Heiko Jessen; Kimberly Lane; Madelene Lindqvist; Thomas Pertel; Alicja Piechocka-Trocha; Srinika Ranasinghe; Eric S Rosenberg; Jenna Rychert; Kailan Sierra-Davidson; Hendrik Streeck
HIV-specific cytolytic CD4 T cell responses during acute HIV infection predict disease outcome.
Science translational medicine 2012;4(123):123ra25.
2012: Philippa C Matthews; Zenele Mncube; Thumbi Ndung'u; Anthony Ogwu; Paolo Paioni; Rebecca Payne; Roger Shapiro; Dewald Steyn; Cloete van Vuuren; Bruce D Walker; Jonathan M Carlson; John Frater; Dominique Goedhals; David Heckerman; Kuan-Hsiang Gary Huang; Pieter Jooste; Jennifer Listgarten; Philip J R Goulder
Co-operative additive effects between HLA alleles in control of HIV-1.
PloS one 2012;7(10):e47799.
2012: Boris Julg; Richard A Murphy; Danielle Poole; Henry Sunpath; Marcus Altfeld; Carmen Castilla; Musie Ghebremichael; Bruce D Walker
Factors predicting discordant virological and immunological responses to antiretroviral therapy in HIV-1 clade C infected Zulu/Xhosa in South Africa.
PloS one 2012;7(2):e31161.
2011: Bruce D Walker; Rafi Ahmed; Stanley Plotkin
Moving ahead an HIV vaccine: use both arms to beat HIV.
Nature medicine 2011;17(10):1194-5.
2011: Johannes F Scheid; Michael S Seaman; Beatrix Ueberheide; Klara Velinzon; Bruce D Walker; Thiago Y K Oliveira; Florencia Pereyra; John Pietzsch; Pascal Poignard; Alexander Abadir; Pamela J Bjorkman; Farid Boulad; Dennis R Burton; Brian T Chait; Ron Diskin; David Fenyo; David D Ho; Arlene Hurley; Florian Klein; Hugo Mouquet; Sunnie Myung; Michel C Nussenzweig
Sequence and structural convergence of broad and potent HIV antibodies that mimic CD4 binding.
Science (New York, N.Y.) 2011;333(6049):1633-7.
2011: Mopo Radebe; Mary van der Stok; Bruce D Walker; Jaclyn K Wright; Marcus Altfeld; Ingrid V Bassett; Karen Bishop; Fundisiwe Chonco; Zenele Mncube; Kriebashnie Nair; Thumbi Ndung'u
Limited immunogenicity of HIV CD8+ T-cell epitopes in acute Clade C virus infection.
The Journal of infectious diseases 2011;204(5):768-76.
2011: Christoph T Berger; Jason M Brenchley; Daniel C Douek; Nicole Frahm; Musie Ghebremichael; Kari L Hartman; Leah M Henry; Daniel E Kaufmann; Beatriz Mothe; Florencia Pereyra; David A Price; Laura E Ruff; Alessandro Sette; John Sidney; Vanessa Venturi; Bruce D Walker; Christian Brander
High-functional-avidity cytotoxic T lymphocyte responses to HLA-B-restricted Gag-derived epitopes associated with relative HIV control.
Journal of virology 2011;85(18):9334-45.
2011: Christina Thobakgale; Gareth Tudor-Williams; Bruce D Walker; Andrew Prendergast; Hendrik Streeck; Marcus Altfeld; Fundisiwe Chonco; Philip J R Goulder; Lungile Maphumulo; Nompumelelo Mkhwanazi; Zenele Mncube; Thumbi Ndung'u
Short communication: CD8(+) T cell polyfunctionality profiles in progressive and nonprogressive pediatric HIV type 1 infection.
AIDS research and human retroviruses 2011;27(9):1005-12.
2011: Vincent Dahirel; Darrell J Irvine; Toshiyuki Miura; Florencia Pereyra; Karthik Shekhar; Shiv Talsania; Bruce D Walker; Todd M Allen; Marcus Altfeld; Mikita Artyomov; Mary Carrington; Arup K Chakraborty
Coordinate linkage of HIV evolution reveals regions of immunological vulnerability.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(28):11530-5.
2011: Zaza M Ndhlovu; Thumbi Ndung'u; Alicja Piechocka-Trocha; Seanna Vine; Dan H Barouch; Philip J R Goulder; Kegakilwe C Koofhethile; Ashley McMullen; Bruce D Walker
Mosaic HIV-1 Gag antigens can be processed and presented to human HIV-specific CD8+ T cells.
Journal of immunology (Baltimore, Md. : 1950) 2011;186(12):6914-24.
2011: Hendrik Streeck; Douglas S Kwon; Augustine Pyo; Michael Flanders; Mathieu F Chevalier; Kenneth Law; Boris Jülg; Kasper Trocha; Jonathan S Jolin; Melis N Anahtar; Jeff Lian; Ildiko Toth; Zabrina L Brumme; J Judy Chang; Tyler Caron; Scott J Rodig; Danny A Milner; Alicja Piechoka-Trocha; Daniel E Kaufmann; Bruce D Walker; Marcus Altfeld
Epithelial adhesion molecules can inhibit HIV-1-specific CD8⁺ T-cell functions.
Blood 2011;117(19):5112-22.
2011: Marianne W Mureithi; Kristen Cohen; Ramona Moodley; Danielle Poole; Zenele Mncube; Anne Kasmar; D Branch Moody; Philip J R Goulder; Bruce D Walker; Marcus Altfeld; Thumbi Ndung'u
Impairment of CD1d-restricted natural killer T cells in chronic HIV type 1 clade C infection.
AIDS research and human retroviruses 2011;27(5):501-9.
2011: Jaclyn K Wright; Vladimir Novitsky; Mark Alan Brockman; Zabrina L Brumme; Chanson J Brumme; Jonathan M Carlson; David Heckerman; Bingxia Wang; Elena Losina; Mopo Leshwedi; Mary van der Stok; Lungile Maphumulo; Nompumelelo Mkhwanazi; Fundisiwe Chonco; Philip J R Goulder; Max Essex; Bruce D Walker; Thumbi Ndung'u
Influence of Gag-protease-mediated replication capacity on disease progression in individuals recently infected with HIV-1 subtype C.
Journal of virology 2011;85(8):3996-4006.
2011: Marta Rodríguez-García; Filippos Porichis; Olivier G de Jong; Karen Levi; Thomas J Diefenbach; Jeffrey D Lifson; Gordon J Freeman; Bruce D Walker; Daniel E Kaufmann; Daniel G Kavanagh
Expression of PD-L1 and PD-L2 on human macrophages is up-regulated by HIV-1 and differentially modulated by IL-10.
Journal of leukocyte biology 2011;89(4):507-15.
2011: Boris Julg; Eshia Stephany Moodley-Govender; Ying Qi; Danni Ramduth; Shabashini Reddy; Zenele Mncube; Xiaojiang Gao; Philip J R Goulder; Roger Detels; Thumbi Ndung'u; Bruce D Walker; Mary Carrington
Possession of HLA class II DRB1*1303 associates with reduced viral loads in chronic HIV-1 clade C and B infection.
The Journal of infectious diseases 2011;203(6):803-9.
2011: Arthur Y Kim; Thomas Kuntzen; Joerg Timm; Brian E Nolan; Melanie A Baca; Laura L Reyor; Andrew C Berical; Andrea J Feller; Kristin L Johnson; Julian Schulze zur Wiesch; Gregory K Robbins; Raymond T Chung; Bruce D Walker; Mary Carrington; Todd M Allen; Georg M Lauer
Spontaneous control of HCV is associated with expression of HLA-B 57 and preservation of targeted epitopes.
Gastroenterology 2011;140(2):686-696.e1.
2011: Victoria O Kasprowicz; Sebastian Brown; Shivan Chetty; Fundisiwe Chonco; Cheryl L Day; Helen A Fletcher; Pamla Govender; Kuan-Hsiang Gary Huang; Anne Kasmar; Ajit Lalvani; Cheryl McClurg; Kerry Millington; Jessica E Mitchell; Nompumelelo Mkhwanazi; Thumbi Ndung'u; Bruce D Walker; Daniel P Webster; Paul Klenerman
A molecular assay for sensitive detection of pathogen-specific T-cells.
PloS one 2011;6(8):e20606.
2011: Mathieu F Chevalier; Boris Jülg; Augustine Pyo; Michael Flanders; Srinika Ranasinghe; Damien Z Soghoian; Douglas S Kwon; Jenna Rychert; Jeffrey Lian; Matthias I Muller; Sam Cutler; Elizabeth McAndrew; Heiko Jessen; Florencia Pereyra; Eric S Rosenberg; Marcus Altfeld; Bruce D Walker; Hendrik Streeck
HIV-1-specific interleukin-21+ CD4+ T cell responses contribute to durable viral control through the modulation of HIV-specific CD8+ T cell function.
Journal of virology 2011;85(2):733-41.
2011: Ravesh Singh; Gaurav Gaiha; Lise Werner; Kevin McKim; Koleka Patience Mlisana; Jeremy Luban; Bruce D Walker; Salim S Abdool Karim; Abraham L Brass; Thumbi Ndung'u
Association of TRIM22 with the type 1 interferon response and viral control during primary HIV-1 infection.
Journal of virology 2011;85(1):208-16.
2010: Isobella Honeyborne; Francisco M Codoñer; Alasdair Leslie; Gareth Tudor-Williams; Graz Luzzi; Thumbi Ndung'u; Bruce D Walker; Philip J R Goulder; Julia G Prado
HLA-Cw*03-restricted CD8+ T-cell responses targeting the HIV-1 gag major homology region drive virus immune escape and fitness constraints compensated for by intracodon variation.
Journal of virology 2010;84(21):11279-88.
2010: Michael Quigley; Florencia Pereyra; Björn Nilsson; Filippos Porichis; Catia Fonseca; Quentin Eichbaum; Boris Julg; Jonathan L Jesneck; Kathleen Brosnahan; Sabrina Imam; Kate Russell; Ildiko Toth; Alicja Piechocka-Trocha; Douglas Dolfi; Jill Angelosanto; alison crawford; Haina Shin; Douglas S Kwon; Jennifer Zupkosky; Loise Francisco; Gordon J Freeman; E John Wherry; Daniel E Kaufmann; Bruce D Walker; Benjamin Ebert; W Nicholas Haining
Transcriptional analysis of HIV-specific CD8+ T cells shows that PD-1 inhibits T cell function by upregulating BATF.
Nature medicine 2010;16(10):1147-51.
2010: Jaclyn K Wright; Zabrina L Brumme; Jonathan M Carlson; David Heckerman; Carl M Kadie; Chanson J Brumme; Bingxia Wang; Elena Losina; Toshiyuki Miura; Fundisiwe Chonco; Mary van der Stok; Zenele Mncube; Karen Bishop; Philip J R Goulder; Bruce D Walker; Mark Alan Brockman; Thumbi Ndung'u
Gag-protease-mediated replication capacity in HIV-1 subtype C chronic infection: associations with HLA type and clinical parameters.
Journal of virology 2010;84(20):10820-31.
2010: Alasdair Leslie; Philippa C Matthews; Jennifer Listgarten; Jonathan M Carlson; Carl Kadie; Thumbi Ndung'u; Christian Brander; Hoosen Coovadia; Bruce D Walker; David Heckerman; Philip J R Goulder
Additive contribution of HLA class I alleles in the immune control of HIV-1 infection.
Journal of virology 2010;84(19):9879-88.
2010: Hugo Mouquet; Johannes F Scheid; Markus J Zoller; Michelle Krogsgaard; Rene G Ott; Shetha Shukair; Maxim N Artyomov; John Pietzsch; Mark Connors; Florencia Pereyra; Bruce D Walker; David D Ho; Patrick C Wilson; Michael S Seaman; Herman N Eisen; Arup K Chakraborty; Thomas J Hope; Jeffrey V Ravetch; Hedda Wardemann; Michel C Nussenzweig
Polyreactivity increases the apparent affinity of anti-HIV antibodies by heteroligation.
Nature 2010;467(7315):591-5.
2010: Nompumelelo Mkhwanazi; Christina Thobakgale; Mary van der Stok; Shabashini Reddy; Zenele Mncube; Fundisiwe Chonco; Bruce D Walker; Marcus Altfeld; Philip J R Goulder; Thumbi Ndung'u
Immunodominant HIV-1-specific HLA-B- and HLA-C-restricted CD8+ T cells do not differ in polyfunctionality.
Virology 2010;405(2):483-91.
2010: Jinghe Huang; Patrick S Burke; Thai Duong Hong Cung; Florencia Pereyra; Ildiko Toth; Bruce D Walker; Luis Borges; Mathias Lichterfeld; Xu G Yu
Leukocyte immunoglobulin-like receptors maintain unique antigen-presenting properties of circulating myeloid dendritic cells in HIV-1-infected elite controllers.
Journal of virology 2010;84(18):9463-71.
2010: Toshiyuki Miura; Zabrina L Brumme; Mark Alan Brockman; Pamela Rosato; Jennifer Sela; Chanson J Brumme; Florencia Pereyra; Daniel E Kaufmann; Alicja Trocha; Brian L Block; Eric S Daar; Elizabeth Connick; Heiko Jessen; Anthony D Kelleher; Eric Rosenberg; Martin Markowitz; Kim Schafer; Florin Vaida; Aikichi Iwamoto; Susan Little; Bruce D Walker
Impaired replication capacity of acute/early viruses in persons who become HIV controllers.
Journal of virology 2010;84(15):7581-91.
2010: B Julg; Florencia Pereyra; M J Buzón; A Piechocka-Trocha; M J Clark; B M Baker; J Lian; T Miura; Javier Martinez-Picado; Marylyn M Addo; Bruce D Walker
Infrequent recovery of HIV from but robust exogenous infection of activated CD4(+) T cells in HIV elite controllers.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2010;51(2):233-8.
2010: B Julg; K L Williams; Sharon Reddy; Karen Bishop; Y Qi; M Carrington; Philip J R Goulder; Thumbi Ndung'u; Bruce D Walker
Enhanced anti-HIV functional activity associated with Gag-specific CD8 T-cell responses.
Journal of virology 2010;84(11):5540-9.
2010: Andrej Kosmrlj; Elizabeth L Read; Ying Qi; Todd M Allen; Marcus Altfeld; Steven G Deeks; Florencia Pereyra; Mary Carrington; Bruce D Walker; Arup K Chakraborty
Effects of thymic selection of the T-cell repertoire on HLA class I-associated control of HIV infection.
Nature 2010;465(7296):350-4.
2010: Morgane Rolland; Jonathan M Carlson; Siriphan Manocheewa; J Victor Swain; Erinn Lanxon-Cookson; Wenjie Deng; Christine M Rousseau; Dana N Raugi; Gerald Learn; Brandon S Maust; Hoosen Coovadia; Thumbi Ndung'u; Philip J R Goulder; Bruce D Walker; Christian Brander; David E Heckerman; James I Mullins
Amino-acid co-variation in HIV-1 Gag subtype C: HLA-mediated selection pressure and compensatory dynamics.
PloS one 2010;5(9):.
2010: Julia G Prado; Andrew Prendergast; Christina Thobakgale; Claudia Molina; Gareth Tudor-Williams; Thumbi Ndung'u; Bruce D Walker; Philip J R Goulder
Replicative capacity of human immunodeficiency virus type 1 transmitted from mother to child is associated with pediatric disease progression rate.
Journal of virology 2010;84(1):492-502.
2009: Ashika Singh; Taryn Page; Penny L Moore; Rachel L Allgaier; Keshni Hiramen; Hoosen M Coovadia; Bruce D Walker; Lynn Morris; Thumbi Ndung'u
Functional and genetic analysis of coreceptor usage by dualtropic HIV-1 subtype C isolates.
Virology 2009;393(1):56-67.
2009: Christina Thobakgale; Andrew Prendergast; Hayley Crawford; Nompumelelo Mkhwanazi; Danni Ramduth; Sharon Reddy; Claudia Molina; Zenele Mncube; Alasdair Leslie; Julia G Prado; Fundi Chonco; Wendy Mphatshwe; Gareth Tudor-Williams; Prakash Jeena; Natasha Blanckenberg; Krista Dong; Photini Kiepiela; Hoosen Coovadia; Thumbi Ndung'u; Bruce D Walker; Philip J R Goulder
Impact of HLA in mother and child on disease progression of pediatric human immunodeficiency virus type 1 infection.
Journal of virology 2009;83(19):10234-44.
2009: Florencia Pereyra; Sarah Palmer; Toshiyuki Miura; Brian L Block; Ann Wiegand; Alissa C Rothchild; Brett Baker; Rachel Rosenberg; Emily Cutrell; Michael S Seaman; John M Coffin; Bruce D Walker
Persistent low-level viremia in HIV-1 elite controllers and relationship to immunologic parameters.
The Journal of infectious diseases 2009;200(6):984-90.
2009: Hendrik Streeck; Jonathan S Jolin; Ying Qi; Bader Yassine-Diab; Randall C Johnson; Douglas S Kwon; Marylyn M Addo; Chanson Brumme; Jean-Pierre Routy; Susan Little; Heiko Jessen; Anthony D Kelleher; Frederick Hecht; Rafick-Pierre Sekaly; Eric S Rosenberg; Bruce D Walker; Mary Carrington; Marcus Altfeld
Human immunodeficiency virus type 1-specific CD8+ T-cell responses during primary infection are major determinants of the viral set point and loss of CD4+ T cells.
Journal of virology 2009;83(15):7641-8.
2009: Estibaliz Lazaro; Sasha Blue Godfrey; Pamela Stamegna; Tobi Ogbechie; Christopher Kerrigan; Mei Zhang; Bruce D Walker; Sylvie Le Gall
Differential HIV epitope processing in monocytes and CD4 T cells affects cytotoxic T lymphocyte recognition.
The Journal of infectious diseases 2009;200(2):236-43.
2009: Mark Alan Brockman; Douglas S Kwon; Daniel P Tighe; David F Pavlik; Pamela C Rosato; Jennifer Sela; Filippos Porichis; Sylvie Le Gall; Michael T Waring; Kristin Moss; Heiko Jessen; Florencia Pereyra; Daniel G Kavanagh; Bruce D Walker; Daniel E Kaufmann
IL-10 is up-regulated in multiple cell types during viremic HIV infection and reversibly inhibits virus-specific T cells.
Blood 2009;114(2):346-56.
2009: Diana M Brainard; Edward Seung; Nicole Frahm; Annaiah Cariappa; Charles C Bailey; William K Hart; Hae-Sook Shin; Sarah F Brooks; Heather L Knight; Quentin Eichbaum; Yong-Guang Yang; Megan Sykes; Bruce D Walker; Gordon J Freeman; Shiv Pillai; Susan V Westmoreland; Christian Brander; Andrew D Luster; Andrew M Tager
Induction of robust cellular and humoral virus-specific adaptive immune responses in human immunodeficiency virus-infected humanized BLT mice.
Journal of virology 2009;83(14):7305-21.
2009: Daniel E Kaufmann; Bruce D Walker
PD-1 and CTLA-4 inhibitory cosignaling pathways in HIV infection and the potential for therapeutic intervention.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(10):5891-7.
2009: Boris Julg; Shabashini Reddy; Mary van der Stok; Smita Kulkarni; Ying Qi; Sara Bass; Bert Gold; Michael A Nalls; George W Nelson; Bruce D Walker; Mary Carrington; Thumbi Ndung'u
Lack of Duffy antigen receptor for chemokines: no influence on HIV disease progression in an African treatment-naive population.
Cell host & microbe 2009;5(5):413-5; author reply 418-9.
2009: Philippa C Matthews; Alasdair Leslie; Aris Katzourakis; Hayley Crawford; Rebecca Payne; Andrew Prendergast; Karen Power; Anthony D Kelleher; Paul Klenerman; Jonathan Carlson; David Heckerman; Thumbi Ndung'u; Bruce D Walker; Todd M Allen; Oliver G Pybus; Philip J R Goulder
HLA footprints on human immunodeficiency virus type 1 are associated with interclade polymorphisms and intraclade phylogenetic clustering.
Journal of virology 2009;83(9):4605-15.
2009: Johannes F Scheid; Hugo Mouquet; Niklas Feldhahn; Bruce D Walker; Florencia Pereyra; Emily Cutrell; Michael S Seaman; John R Mascola; Richard Wyatt; Hedda Wardemann; Michel C Nussenzweig
A method for identification of HIV gp140 binding memory B cells in human blood.
Journal of immunological methods 2009;343(2):65-7.
2009: Hayley Crawford; Wendy Lumm; Alasdair Leslie; Malinda Schaefer; Debrah Boeras; Julia G Prado; Jianming Tang; Paul Farmer; Thumbi Ndung'u; Shabir Lakhi; Jill Gilmour; Paul A Goepfert; Bruce D Walker; Richard A Kaslow; Joseph Mulenga; Susan Allen; Philip J R Goulder; Eric Hunter
Evolution of HLA-B*5703 HIV-1 escape mutations in HLA-B*5703-positive individuals and their transmission recipients.
The Journal of experimental medicine 2009;206(4):909-21.
2009: Huabiao Chen; Alicja Piechocka-Trocha; Toshiyuki Miura; Mark Alan Brockman; Boris D Julg; Brett M Baker; Alissa C Rothchild; Brian L Block; Arne Schneidewind; Tomohiko Koibuchi; Florencia Pereyra; Todd M Allen; Bruce D Walker
Differential neutralization of human immunodeficiency virus (HIV) replication in autologous CD4 T cells by HIV-specific cytotoxic T lymphocytes.
Journal of virology 2009;83(7):3138-49.
2009: Arne Schneidewind; Zabrina L Brumme; Chanson J Brumme; Karen A Power; Laura L Reyor; Kristin M O'Sullivan; Adrianne Gladden; Ursula Hempel; Thomas Kuntzen; Yaoyu E Wang; Cesar Oniangue-Ndza; Heiko Jessen; Martin Markowitz; Eric S Rosenberg; Rafick-Pierre Sékaly; Anthony D Kelleher; Bruce D Walker; Todd M Allen
Transmission and long-term stability of compensated CD8 escape mutations.
Journal of virology 2009;83(8):3993-7.
2009: Christine M Rousseau; David W Lockhart; Jennifer Listgarten; Stephen N Maley; Carl Kadie; Gerald Learn; David C Nickle; David E Heckerman; Wenjie Deng; Christian Brander; Thumbi Ndung'u; Hoosen Coovadia; Philip J R Goulder; Bette T Korber; Bruce D Walker; James I Mullins
Rare HLA drive additional HIV evolution compared to more frequent alleles.
AIDS research and human retroviruses 2009;25(3):297-303.
2009: Toshiyuki Miura; Mark Alan Brockman; Arne Schneidewind; Michael Lobritz; Florencia Pereyra; Almas Rathod; Brian L Block; Zabrina L Brumme; Chanson J Brumme; Brett Baker; Alissa C Rothchild; Bin Li; Alicja Trocha; Emily Cutrell; Nicole Frahm; Christian Brander; Ildiko Toth; Eric J Arts; Todd M Allen; Bruce D Walker
HLA-B57/B*5801 human immunodeficiency virus type 1 elite controllers select for rare gag variants associated with reduced viral replication capacity and strong cytotoxic T-lymphocyte [corrected] recognition.
Journal of virology 2009;83(6):2743-55.
2009: Yaoyu E Wang; Bin Li; Jonathan M Carlson; Hendrik Streeck; Adrianne D Gladden; Robert Goodman; Arne Schneidewind; Karen A Power; Ildiko Toth; Nicole Frahm; Galit Alter; Christian Brander; Mary Carrington; Bruce D Walker; Marcus Altfeld; David Heckerman; Todd M Allen
Protective HLA class I alleles that restrict acute-phase CD8+ T-cell responses are associated with viral escape mutations located in highly conserved regions of human immunodeficiency virus type 1.
Journal of virology 2009;83(4):1845-55.
2009: Hendrik Streeck; Heiko Jessen; Claudia Kuecherer; Bin Li; Arne B Jessen; Stephan Dupke; Axel Baumgarten; Ingrid Stahmer; Jan van Lunzen; Marcus Altfeld; Bruce D Walker; Todd M Allen
Epidemiologically linked transmission of HIV-1 illustrates the impact of host genetics on virological outcome.
AIDS (London, England) 2009;23(2):259-62.
2009: Danni Ramduth; Cheryl L Day; Christina Thobakgale; Nompumelelo P Mkhwanazi; Chantal de Pierres; Sharon Reddy; Mary van der Stok; Zenele Mncube; Kriebashne Nair; Eshia Stephany Moodley-Govender; Daniel E Kaufmann; Hendrik Streeck; Hoosen M Coovadia; Photini Kiepiela; Philip J R Goulder; Bruce D Walker
Immunodominant HIV-1 Cd4+ T cell epitopes in chronic untreated clade C HIV-1 infection.
PloS one 2009;4(4):e5013.
2009: Toshiyuki Miura; Mark Alan Brockman; Zabrina L Brumme; Chanson J Brumme; Florencia Pereyra; Alicja Trocha; Brian L Block; Arne Schneidewind; Todd M Allen; David Heckerman; Bruce D Walker
HLA-associated alterations in replication capacity of chimeric NL4-3 viruses carrying gag-protease from elite controllers of human immunodeficiency virus type 1.
Journal of virology 2009;83(1):140-9.
2008: Sihong Huang; Jacqueline Dunkley-Thompson; Yanhua Tang; Eric A Macklin; Julianne Steel-Duncan; Indira Singh-Minott; Elizabeth G Ryland; Monica Smikle; Bruce D Walker; Celia D C Christie; Margaret E Feeney
Deficiency of HIV-Gag-specific T cells in early childhood correlates with poor viral containment.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(11):8103-11.
2008: Jonathan M Carlson; Zabrina L Brumme; Christine M Rousseau; Chanson J Brumme; Philippa Matthews; Carl Kadie; James I Mullins; Bruce D Walker; P Richard Harrigan; Philip J R Goulder; David Heckerman
Phylogenetic dependency networks: inferring patterns of CTL escape and codon covariation in HIV-1 Gag.
PLoS computational biology 2008;4(11):e1000225.
2008: Zabrina L Brumme; Chanson J Brumme; Jonathan Carlson; Hendrik Streeck; Mina John; Quentin Eichbaum; Brian L Block; Brett Baker; Carl Kadie; Martin Markowitz; Heiko Jessen; Anthony D Kelleher; Eric Rosenberg; John Kaldor; Yuko Yuki; Mary Carrington; Todd M Allen; Simon Mallal; Marcus Altfeld; David Heckerman; Bruce D Walker
Marked epitope- and allele-specific differences in rates of mutation in human immunodeficiency type 1 (HIV-1) Gag, Pol, and Nef cytotoxic T-lymphocyte epitopes in acute/early HIV-1 infection.
Journal of virology 2008;82(18):9216-27.
2008: Philippa C Matthews; Andrew Prendergast; Alasdair Leslie; Hayley Crawford; Rebecca Payne; Christine M Rousseau; Morgane Rolland; Isobella Honeyborne; Jonathan Carlson; Carl Kadie; Christian Brander; Karen Bishop; Nonkululeko Mlotshwa; James I Mullins; Hoosen Coovadia; Thumbi Ndung'u; Bruce D Walker; David Heckerman; Philip J R Goulder
Central role of reverting mutations in HLA associations with human immunodeficiency virus set point.
Journal of virology 2008;82(17):8548-59.
2008: Toshiyuki Miura; Mark Alan Brockman; Chanson J Brumme; Zabrina L Brumme; Jonathan M Carlson; Florencia Pereyra; Alicja Trocha; Marylyn M Addo; Brian L Block; Alissa C Rothchild; Brett M Baker; Theresa Flynn; Arne Schneidewind; Bin Li; Yaoyu E Wang; David Heckerman; Todd M Allen; Bruce D Walker
Genetic characterization of human immunodeficiency virus type 1 in elite controllers: lack of gross genetic defects or common amino acid changes.
Journal of virology 2008;82(17):8422-30.
2008: W Nicholas Haining; Benjamin L Ebert; Aravind Subrmanian; E John Wherry; Quentin Eichbaum; John W Evans; Raymond Mak; Stephen Rivoli; Jennifer Pretz; Jill Angelosanto; John S Smutko; Bruce D Walker; Susan M Kaech; Rafi Ahmed; Lee M Nadler; Todd R Golub
Identification of an evolutionarily conserved transcriptional signature of CD8 memory differentiation that is shared by T and B cells.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(3):1859-68.
2008: Andrew Prendergast; Wendy Mphatswe; Gareth Tudor-Williams; Mpho Rakgotho; Visva Pillay; Christina Thobakgale; Noel McCarthy; Lynn Morris; Bruce D Walker; Philip J R Goulder
Early virological suppression with three-class antiretroviral therapy in HIV-infected African infants.
AIDS (London, England) 2008;22(11):1333-43.
2008: Christine M Rousseau; Marcus G Daniels; Jonathan M Carlson; Carl Kadie; Hayley Crawford; Andrew Prendergast; Philippa Matthews; Rebecca Payne; Morgane Rolland; Dana N Raugi; Brandon S Maust; Gerald Learn; David C Nickle; Hoosen Coovadia; Thumbi Ndung'u; Nicole Frahm; Christian Brander; Bruce D Walker; Philip J R Goulder; Tanmoy Bhattacharya; David E Heckerman; Bette T Korber; James I Mullins
HLA class I-driven evolution of human immunodeficiency virus type 1 subtype c proteome: immune escape and viral load.
Journal of virology 2008;82(13):6434-46.
2008: Arne Schneidewind; Mark Alan Brockman; John Sidney; Yaoyu E Wang; Huabiao Chen; Todd J Suscovich; Bin Li; Rahma I Adam; Rachel L Allgaier; Bianca R Mothé; Thomas Kuntzen; Cesar Oniangue-Ndza; Alicja Trocha; Xu G Yu; Christian Brander; Alessandro Sette; Bruce D Walker; Todd M Allen
Structural and functional constraints limit options for cytotoxic T-lymphocyte escape in the immunodominant HLA-B27-restricted epitope in human immunodeficiency virus type 1 capsid.
Journal of virology 2008;82(11):5594-605.
2008: Hendrik Streeck; Zabrina L Brumme; Michael Anastario; Kristin W Cohen; Jonathan S Jolin; Angela Meier; Chanson J Brumme; Eric S Rosenberg; Galit Alter; Todd M Allen; Bruce D Walker; Marcus Altfeld
Antigen load and viral sequence diversification determine the functional profile of HIV-1-specific CD8+ T cells.
PLoS medicine 2008;5(5):e100.
2008: Cheryl L Day; Nompumelelo Mkhwanazi; Sharon Reddy; Zenele Mncube; Mary van der Stok; Paul Klenerman; Bruce D Walker
Detection of polyfunctional Mycobacterium tuberculosis-specific T cells and association with viral load in HIV-1-infected persons.
The Journal of infectious diseases 2008;197(7):990-9.
2008: Victoria Kasprowicz; Scott M Ward; Alison Turner; Alexandros Grammatikos; Brian E Nolan; Lia L Lewis-Ximenez; Charles Sharp; Jenny Woodruff; Vicki Fleming; Stuart Sims; Bruce D Walker; Andrew K Sewell; Georg M Lauer; Paul Klenerman
Defining the directionality and quality of influenza virus-specific CD8+ T cell cross-reactivity in individuals infected with hepatitis C virus.
The Journal of clinical investigation 2008;118(3):1143-53.
2008: Aviva Joseph; Jian Hua Zheng; Antonia Follenzi; Teresa P DiLorenzo; Kaori Sango; Jaime Hyman; Ken Chen; Alicja Piechocka-Trocha; Christian Brander; Erik Hooijberg; Dario A Vignali; Bruce D Walker; Harris Goldstein
Lentiviral vectors encoding human immunodeficiency virus type 1 (HIV-1)-specific T-cell receptor genes efficiently convert peripheral blood CD8 T lymphocytes into cytotoxic T lymphocytes with potent in vitro and in vivo HIV-1-specific inhibitory activity.
Journal of virology 2008;82(6):3078-89.
2008: Victoria Kasprowicz; julian schulze zur wiesch; Thomas Kuntzen; Brian E Nolan; Steven Longworth; Andrew Berical; Jenna Blum; Cory McMahon; Laura L Reyor; nahel elias; William W Kwok; Barbara G McGovern; Gordon Freeman; Raymond T Chung; Paul Klenerman; Lia L Lewis-Ximenez; Bruce D Walker; Todd M Allen; Arthur Y Kim; Georg M Lauer
High level of PD-1 expression on hepatitis C virus (HCV)-specific CD8+ and CD4+ T cells during acute HCV infection, irrespective of clinical outcome.
Journal of virology 2008;82(6):3154-60.
2008: Nicole Frahm; David C Nickle; Caitlyn H Linde; Daniel E Cohen; Rosario Zuñiga; Aldo Lucchetti; Timothy Roach; Bruce D Walker; Todd M Allen; Bette T Korber; James I Mullins; Christian Brander
Increased detection of HIV-specific T cell responses by combination of central sequences with comparable immunogenicity.
AIDS (London, England) 2008;22(4):447-56.
2008: Florencia Pereyra; Marylyn M Addo; Daniel E Kaufmann; Yang Liu; Toshiyuki Miura; Almas Rathod; Brett Baker; Alicja Trocha; Rachel Rosenberg; Elizabeth Mackey; Peggy Ueda; Zhigang Lu; Daniel Cohen; Terri Wrin; Christos J Petropoulos; Eric S Rosenberg; Bruce D Walker
Genetic and immunologic heterogeneity among persons who control HIV infection in the absence of therapy.
The Journal of infectious diseases 2008;197(4):563-71.
2008: Danni Ramduth; Christina Thobakgale; Nompumelelo P Mkhwanazi; Chantal De Pierres; Sharon Reddy; Mary van der Stok; Zenele Mncube; Wendy Mphatswe; Natasha Blanckenberg; Ayanda Cengimbo; Andrew Prendergast; Gareth Tudor-Williams; Krista Dong; Prakash Jeena; Hoosen M Coovadia; Cheryl L Day; Photini Kiepiela; Philip J R Goulder; Bruce D Walker
Detection of HIV type 1 gag-specific CD4(+) T cell responses in acutely infected infants.
AIDS research and human retroviruses 2008;24(2):265-70.
2008: John W Northfield; Victoria Kasprowicz; Michaela Lucas; Nadine Kersting; Bertram Bengsch; Bertram Bengsh; Arthur Kim; Rodney E Phillips; Bruce D Walker; Robert Thimme; Georg M Lauer; Paul Klenerman
CD161 expression on hepatitis C virus-specific CD8+ T cells suggests a distinct pathway of T cell differentiation.
Hepatology (Baltimore, Md.) 2008;47(2):396-406.
2008: Kholiswa Ngumbela; Cheryl L Day; Zenele Mncube; Kriebashnie Nair; Danni Ramduth; Christina Thobakgale; Eshia Stephany Moodley-Govender; Sharon Reddy; C de Pierres; Nompumelelo Mkhwanazi; Karen Bishop; Mary van der Stok; N Ismail; Isobella Honeyborne; Hayley Crawford; Daniel G Kavanagh; Christine M Rousseau; David C Nickle; James Mullins; David Heckerman; Bette Korber; Hoosen Coovadia; Photini Kiepiela; Philip J R Goulder; Bruce D Walker
Targeting of a CD8 T cell env epitope presented by HLA-B*5802 is associated with markers of HIV disease progression and lack of selection pressure.
AIDS research and human retroviruses 2008;24(1):72-82.
2008: Morgane Rolland; David Heckerman; Wenjie Deng; Christine M Rousseau; Hoosen Coovadia; Karen Bishop; Philip J R Goulder; Bruce D Walker; Christian Brander; James I Mullins
Broad and Gag-biased HIV-1 epitope repertoires are associated with lower viral loads.
PloS one 2008;3(1):e1424.
2007: Christina Thobakgale; Danni Ramduth; Sharon Reddy; Nompumelelo Mkhwanazi; Chantal de Pierres; Eshia Stephany Moodley-Govender; Wendy Mphatswe; Natasha Blanckenberg; Ayanda Cengimbo; Andrew Prendergast; Gareth Tudor-Williams; Krista Dong; Prakash Jeena; Gurpreet Kindra; Raziya Bobat; Hoosen Coovadia; Photini Kiepiela; Bruce D Walker; Philip J R Goulder
Human immunodeficiency virus-specific CD8+ T-cell activity is detectable from birth in the majority of in utero-infected infants.
Journal of virology 2007;81(23):12775-84.
2007: Mathias Lichterfeld; Daniel G Kavanagh; Katie L Williams; Beenu Moza; Stanley K Mui; ToshiYuki Miura; Rohini Sivamurthy; Rachel L Allgaier; Florencia Pereyra; Alicja Trocha; Margaret E Feeney; Rajesh T Gandhi; Eric S Rosenberg; Marcus Altfeld; Todd M Allen; Rachel Allen; Bruce D Walker; Eric Sundberg; Xu G Yu
A viral CTL escape mutation leading to immunoglobulin-like transcript 4-mediated functional inhibition of myelomonocytic cells.
The Journal of experimental medicine 2007;204(12):2813-24.
2007: Nicole Frahm; Daniel E Kaufmann; Karina Yusim; Mark Muldoon; Can Kesmir; Caitlyn H Linde; Will Fischer; Todd M Allen; Bin Li; Ben H McMahon; Kellie L Faircloth; Hannah S Hewitt; Elizabeth W Mackey; Toshiyuki Miura; Ashok Khatri; Steven Wolinsky; Andrew McMichael; Robert Funkhouser; Bruce D Walker; Christian Brander; Bette T Korber
Increased sequence diversity coverage improves detection of HIV-specific T cell responses.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(10):6638-50.
2007: Sylvie Le Gall; Pamela Stamegna; Bruce D Walker
Portable flanking sequences modulate CTL epitope processing.
The Journal of clinical investigation 2007;117(11):3563-75.
2007: Daniel E Kaufmann; Daniel G Kavanagh; Florencia Pereyra; John J Zaunders; Elizabeth W Mackey; Toshiyuki Miura; Sarah Palmer; Mark Alan Brockman; Almas Rathod; Alicja Piechocka-Trocha; Brett Baker; Baogong Zhu; Sylvie Le Gall; Michael T Waring; Ryan Ahern; Kristin Moss; Anthony D Kelleher; John M Coffin; Gordon J Freeman; Eric S Rosenberg; Bruce D Walker
Upregulation of CTLA-4 by HIV-specific CD4+ T cells correlates with disease progression and defines a reversible immune dysfunction.
Nature immunology 2007;8(11):1246-54.
2007: Xu G Yu; Mathias Lichterfeld; Katie L Williams; Javier Martinez-Picado; Bruce D Walker
Random T-cell receptor recruitment in human immunodeficiency virus type 1 (HIV-1)-specific CD8+ T cells from genetically identical twins infected with the same HIV-1 strain.
Journal of virology 2007;81(22):12666-9.
2007: Mark Alan Brockman; Arne Schneidewind; Matthew P Lahaie; Aaron Schmidt; Toshiyuki Miura; Ivna Desouza; Faina Ryvkin; Cynthia A Derdeyn; Susan Allen; Eric Hunter; Joseph Mulenga; Paul A Goepfert; Bruce D Walker; Todd M Allen
Escape and compensation from early HLA-B57-mediated cytotoxic T-lymphocyte pressure on human immunodeficiency virus type 1 Gag alter capsid interactions with cyclophilin A.
Journal of virology 2007;81(22):12608-18.
2007: Nicole Frahm; Karina Yusim; Todd J Suscovich; Sharon Adams; John Sidney; Peter T Hraber; Hannah S Hewitt; Caitlyn H Linde; Daniel G Kavanagh; Tonia Woodberry; Leah M Henry; Kellie Faircloth; Jennifer Listgarten; Carl Kadie; Nebojsa Jojic; Kaori Sango; Nancy V Brown; Eunice Pae; M Tauheed Zaman; Florian Bihl; Ashok Khatri; Mina John; Simon Mallal; Francesco M Marincola; Bruce D Walker; Alessandro Sette; David Heckerman; Bette T Korber; Christian Brander
Extensive HLA class I allele promiscuity among viral CTL epitopes.
European journal of immunology 2007;37(9):2419-33.
2007: julian schulze zur wiesch; Georg M Lauer; Joerg Timm; Thomas Kuntzen; Martin Neukamm; Andrew Berical; Andrea M Jones; Brian E Nolan; Steve A Longworth; Victoria Kasprowicz; Cory McMahon; Alysse Wurcel; Ansgar W Lohse; Lia L Lewis-Ximenez; Raymond T Chung; Arthur Y Kim; Todd M Allen; Bruce D Walker
Immunologic evidence for lack of heterologous protection following resolution of HCV in patients with non-genotype 1 infection.
Blood 2007;110(5):1559-69.
2007: Bruce D Walker
Elite control of HIV Infection: implications for vaccines and treatment.
Topics in HIV medicine : a publication of the International AIDS Society, USA 2007;15(4):134-6.
2007: Diana M Brainard; Andrew M Tager; Joseph Misdraji; Nicole Frahm; Mathias Lichterfeld; Rika Draenert; Christian Brander; Bruce D Walker; Andrew D Luster
Decreased CXCR3+ CD8 T cells in advanced human immunodeficiency virus infection suggest that a homing defect contributes to cytotoxic T-lymphocyte dysfunction.
Journal of virology 2007;81(16):8439-50.
2007: Hayley Crawford; Julia G Prado; Alasdair Leslie; Stéphane Hué; Isobella Honeyborne; Sharon Reddy; Mary van der Stok; Zenele Mncube; Christian Brander; Christine M Rousseau; James I Mullins; Richard A Kaslow; Paul A Goepfert; Susan Allen; Eric Hunter; Joseph Mulenga; Photini Kiepiela; Bruce D Walker; Philip J R Goulder
Compensatory mutation partially restores fitness and delays reversion of escape mutation within the immunodominant HLA-B*5703-restricted Gag epitope in chronic human immunodeficiency virus type 1 infection.
Journal of virology 2007;81(15):8346-51.
2007: Zabrina L Brumme; Chanson J Brumme; David Heckerman; Bette T Korber; Marcus Daniels; Jonathan Carlson; Carl Kadie; Tanmoy Bhattacharya; Celia Chui; James Szinger; Theresa Mo; Hogg Robert; Julio S G Montaner; Nicole Frahm; Christian Brander; Bruce D Walker; P Richard Harrigan
Evidence of differential HLA class I-mediated viral evolution in functional and accessory/regulatory genes of HIV-1.
PLoS pathogens 2007;3(7):e94.
2007: Hendrik Streeck; Mathias Lichterfeld; Galit Alter; Angela Meier; Nickolas Teigen; Bader Yassine-Diab; Harlyn K Sidhu; Susan Little; Anthony D Kelleher; Jean-Pierre Routy; Eric S Rosenberg; Rafick-Pierre Sekaly; Bruce D Walker; Marcus Altfeld
Recognition of a defined region within p24 gag by CD8+ T cells during primary human immunodeficiency virus type 1 infection in individuals expressing protective HLA class I alleles.
Journal of virology 2007;81(14):7725-31.
2007: Wendy Mphatswe; Natasha Blanckenberg; Gareth Tudor-Williams; Andrew Prendergast; Christina Thobakgale; Nompumelelo Mkhwanazi; Noel McCarthy; Bruce D Walker; Photini Kiepiela; Philip J R Goulder
High frequency of rapid immunological progression in African infants infected in the era of perinatal HIV prophylaxis.
AIDS (London, England) 2007;21(10):1253-61.
2007: John Frater; Helen Brown; Annette Oxenius; Huldrych Günthard; Bernard Hirschel; N Robinson; Alasdair Leslie; Rebecca Payne; Hayley Crawford; Andrew Prendergast; Christian Brander; Photini Kiepiela; Bruce D Walker; Philip J R Goulder; A McLean; Rodney E Phillips
Effective T-cell responses select human immunodeficiency virus mutants and slow disease progression.
Journal of virology 2007;81(12):6742-51.
2007: Joerg Timm; M Neukamm; Thomas Kuntzen; Arthur Y Kim; Raymond T Chung; Christian Brander; Georg M Lauer; Bruce D Walker; Todd M Allen
Characterization of full-length hepatitis C virus genotype 4 sequences.
Journal of viral hepatitis 2007;14(5):330-7.
2007: Christine M Rousseau; Gerald Learn; Tanmoy Bhattacharya; David C Nickle; David Heckerman; Senica Chetty; Christian Brander; Philip J R Goulder; Bruce D Walker; Photini Kiepiela; Bette T Korber; James I Mullins
Extensive intrasubtype recombination in South African human immunodeficiency virus type 1 subtype C infections.
Journal of virology 2007;81(9):4492-500.
2007: Hendrik Streeck; Becky Schweighardt; Heiko Jessen; Rachel L Allgaier; Terri Wrin; Eric W Stawiski; Arne B Jessen; Todd M Allen; Bruce D Walker; Marcus Altfeld
Loss of HIV-1-specific T-cell responses associated with very rapid HIV-1 disease progression.
AIDS (London, England) 2007;21(7):889-91.
2007: Mathias Lichterfeld; Xu G Yu; Stanley K Mui; Katie L Williams; Alicja Trocha; Mark Alan Brockman; Rachel L Allgaier; Michael T Waring; Tomohiko Koibuchi; Mary N Johnston; Daniel Cohen; Todd M Allen; Eric S Rosenberg; Bruce D Walker; Marcus Altfeld
Selective depletion of high-avidity human immunodeficiency virus type 1 (HIV-1)-specific CD8+ T cells after early HIV-1 infection.
Journal of virology 2007;81(8):4199-214.
2007: Isobella Honeyborne; Andrew Prendergast; Florencia Pereyra; Alasdair Leslie; Hayley Crawford; Rebecca Payne; Sharon Reddy; Karen Bishop; Eshia Stephany Moodley-Govender; Kriebashnie Nair; Mary van der Stok; Noel McCarthy; Christine M Rousseau; Marylyn M Addo; James I Mullins; Christian Brander; Photini Kiepiela; Bruce D Walker; Philip J R Goulder
Control of human immunodeficiency virus type 1 is associated with HLA-B*13 and targeting of multiple gag-specific CD8+ T-cell epitopes.
Journal of virology 2007;81(7):3667-72.
2007: Xu G Yu; Mathias Lichterfeld; Senica Chetty; Katie L Williams; Stanley K Mui; Toshiyuki Miura; Nicole Frahm; Margaret E Feeney; Yanhua Tang; Florencia Pereyra; Montiago X LaBute; Katja Pfafferott; Alasdair Leslie; Hayley Crawford; Rachel L Allgaier; William H Hildebrand; Richard A Kaslow; Christian Brander; Todd M Allen; Eric S Rosenberg; Photini Kiepiela; Madhu Vajpayee; Paul A Goepfert; Marcus Altfeld; Philip J R Goulder; Bruce D Walker
Mutually exclusive T-cell receptor induction and differential susceptibility to human immunodeficiency virus type 1 mutational escape associated with a two-amino-acid difference between HLA class I subtypes.
Journal of virology 2007;81(4):1619-31.
2007: Morgane Rolland; David C Nickle; Wenjie Deng; Nicole Frahm; Christian Brander; Gerald Learn; David Heckerman; Nebojsa Jojic; Vladimir Jojic; Bruce D Walker; James I Mullins
Recognition of HIV-1 peptides by host CTL is related to HIV-1 similarity to human proteins.
PloS one 2007;2(9):e823.
2007: Bruce D Walker
HIV controllers: an untapped source of clues to overcoming HIV infection.
Research initiative, treatment action : RITA 2007;12(2):21-2.
2007: Marylyn M Addo; Rika Draenert; Almas Rathod; Cori L Verrill; Benjamin T Davis; Rajesh T Gandhi; Gregory Robbins; Nesli Basgoz; David R Stone; Daniel E Cohen; Mary N Johnston; Theresa Flynn; Alysse Wurcel; Eric S Rosenberg; Marcus Altfeld; Bruce D Walker
Fully differentiated HIV-1 specific CD8+ T effector cells are more frequently detectable in controlled than in progressive HIV-1 infection.
PloS one 2007;2(3):e321.
2007: Will Fischer; Simon Perkins; James Theiler; Tanmoy Bhattacharya; Karina Yusim; Robert Funkhouser; Carla Kuiken; Barton Haynes; Norman L Letvin; Bruce D Walker; Beatrice H Hahn; Bette T Korber
Polyvalent vaccines for optimal coverage of potential T-cell epitopes in global HIV-1 variants.
Nature medicine 2007;13(1):100-6.
2007: Photini Kiepiela; Kholiswa Ngumbela; Christina Thobakgale; Danni Ramduth; Isobella Honeyborne; Eshia Stephany Moodley-Govender; Sharon Reddy; Chantal de Pierres; Zenele Mncube; Nompumelelo Mkhwanazi; Karen Bishop; Mary van der Stok; Kriebashnie Nair; Nasreen Khan; Hayley Crawford; Rebecca Payne; Alasdair Leslie; Julia G Prado; Andrew Prendergast; John Frater; Noel McCarthy; Christian Brander; Gerald Learn; David C Nickle; Christine M Rousseau; Hoosen Coovadia; James I Mullins; David Heckerman; Bruce D Walker; Philip J R Goulder
CD8+ T-cell responses to different HIV proteins have discordant associations with viral load.
Nature medicine 2007;13(1):46-53.
2007: Cheryl L Day; Photini Kiepiela; Alasdair Leslie; Mary van der Stok; Kriebashnie Nair; Nasreen Ismail; Isobella Honeyborne; Hayley Crawford; Hoosen M Coovadia; Philip J R Goulder; Bruce D Walker; Paul Klenerman
Proliferative capacity of epitope-specific CD8 T-cell responses is inversely related to viral load in chronic human immunodeficiency virus type 1 infection.
Journal of virology 2007;81(1):434-8.
2006: Arthur Y Kim; julian schulze zur wiesch; Thomas Kuntzen; Joerg Timm; Daniel E Kaufmann; Jared E Duncan; Andrea M Jones; Alysse Wurcel; Benjamin T Davis; Rajesh T Gandhi; Gregory Robbins; Todd M Allen; Raymond T Chung; Georg M Lauer; Bruce D Walker
Impaired hepatitis C virus-specific T cell responses and recurrent hepatitis C virus in HIV coinfection.
PLoS medicine 2006;3(12):e492.
2006: Marcus Altfeld; Elizabeth T Kalife; Ying Qi; Hendrik Streeck; Mathias Lichterfeld; Mary N Johnston; Nicole C Burgett; Martha E Swartz; Amy Yang; Galit Alter; Xu G Yu; Angela Meier; Jürgen K Rockstroh; Todd M Allen; Heiko Jessen; Eric S Rosenberg; Mary Carrington; Bruce D Walker
HLA Alleles Associated with Delayed Progression to AIDS Contribute Strongly to the Initial CD8(+) T Cell Response against HIV-1.
PLoS medicine 2006;3(10):e403.
2006: John J Zaunders; Susanna Ip; Mee Ling Munier; Daniel E Kaufmann; Kazuo Suzuki; Choechoe Brereton; Sarah Sasson; Nabila Seddiki; Kersten Koelsch; Alan Landay; Pat Grey; Robert Finlayson; John Kaldor; Eric S Rosenberg; Bruce D Walker; Barbara Fazekas De St Groth; David A Cooper; Anthony D Kelleher
Infection of CD127+ (interleukin-7 receptor+) CD4+ cells and overexpression of CTLA-4 are linked to loss of antigen-specific CD4 T cells during primary human immunodeficiency virus type 1 infection.
Journal of virology 2006;80(20):10162-72.
2006: Alasdair Leslie; David A Price; Pamela Mkhize; Karen Bishop; Almas Rathod; Cheryl Day; Hayley Crawford; Isobella Honeyborne; Tedi E Asher; Graz Luzzi; Anne Edwards; Christine M Rousseau; Christine M Rosseau; James I Mullins; Gareth Tudor-Williams; Vas Novelli; Christian Brander; Daniel C Douek; Photini Kiepiela; Bruce D Walker; Philip J R Goulder
Differential selection pressure exerted on HIV by CTL targeting identical epitopes but restricted by distinct HLA alleles from the same HLA supertype.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(7):4699-708.
2006: E John Wherry; Cheryl L Day; Rika Draenert; Joseph D Miller; Photini Kiepiela; Tonia Woodberry; Christian Brander; Marylyn M Addo; Paul Klenerman; Rafi Ahmed; Bruce D Walker
HIV-specific CD8 T cells express low levels of IL-7Ralpha: implications for HIV-specific T cell memory.
Virology 2006;353(2):366-73.
2006: Cheryl L Day; Daniel E Kaufmann; Photini Kiepiela; Julia A Brown; Eshia Stephany Moodley-Govender; Sharon Reddy; Elizabeth W Mackey; Joseph D Miller; Alasdair Leslie; Chantal DePierres; Zenele Mncube; Jaikumar Duraiswamy; Baogong Zhu; Quentin Eichbaum; Marcus Altfeld; E John Wherry; Hoosen M Coovadia; Philip J R Goulder; Paul Klenerman; Rafi Ahmed; Gordon J Freeman; Bruce D Walker
PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression.
Nature 2006;443(7109):350-4.
2006: Hendrik Streeck; Heiko Jessen; Galit Alter; Nickolas Teigen; Michael T Waring; Arne Jessen; Ingrid Stahmer; Jan van Lunzen; Mathias Lichterfeld; Xiaojiang Gao; Todd M Allen; Mary Carrington; Bruce D Walker; Jürgen K Rockstroh; Marcus Altfeld
Immunological and virological impact of highly active antiretroviral therapy initiated during acute HIV-1 infection.
The Journal of infectious diseases 2006;194(6):734-9.
2006: Christine M Rousseau; Brian A Birditt; Angela R McKay; Julia N Stoddard; Tsan Chun Lee; Sherry McLaughlin; Sarah W Moore; Nice Shindo; Gerald Learn; Bette T Korber; Christian Brander; Philip J R Goulder; Photini Kiepiela; Bruce D Walker; James I Mullins
Large-scale amplification, cloning and sequencing of near full-length HIV-1 subtype C genomes.
Journal of virological methods 2006;136(1-2):118-25.
2006: Christian Brander; Nicole Frahm; Bruce D Walker
The challenges of host and viral diversity in HIV vaccine design.
Current opinion in immunology 2006;18(4):430-7.
2006: Erik Martinez-Hackert; Nadja Anikeeva; Spyros A Kalams; Bruce D Walker; Wayne A Hendrickson; Yuri Sykulev
Structural basis for degenerate recognition of natural HIV peptide variants by cytotoxic lymphocytes.
The Journal of biological chemistry 2006;281(29):20205-12.
2006: Mathias Lichterfeld; Katie L Williams; Stanley K Mui; Shivani S Shah; Bianca R Mothe; Alessandro Sette; Arthur Kim; Mary N Johnston; Nicole C Burgett; Nicole Frahm; Daniel Cohen; Christian Brander; Eric S Rosenberg; Bruce D Walker; Marcus Altfeld; Xu G Yu
T cell receptor cross-recognition of an HIV-1 CD8+ T cell epitope presented by closely related alleles from the HLA-A3 superfamily.
International immunology 2006;18(7):1179-88.
2006: Barbara McGovern; Alysse Wurcel; Arthur Y Kim; julian schulze zur wiesch; Ioana Bica; M Tauheed Zaman; Joerg Timm; Bruce D Walker; Georg M Lauer
Acute hepatitis C virus infection in incarcerated injection drug users.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2006;42(12):1663-70.
2006: Isobella Honeyborne; Almas Rathod; Rico Buchli; Danni Ramduth; Eshia Stephany Moodley-Govender; Prinisha Rathnavalu; Senica Chetty; Cheryl Day; Christian Brander; William H Hildebrand; Bruce D Walker; Photini Kiepiela; Philip J R Goulder
Motif inference reveals optimal CTL epitopes presented by HLA class I alleles highly prevalent in southern Africa.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(8):4699-705.
2006: Florian Bihl; Nicole Frahm; Loriana Di Giammarino; John Sidney; Mina John; Karina Yusim; Tonia Woodberry; Kaori Sango; Hannah S Hewitt; Leah Henry; Caitlyn H Linde; John V Chisholm; Tauheed M Zaman; Eunice Pae; Simon Mallal; Bruce D Walker; Alessandro Sette; Bette T Korber; David Heckerman; Christian Brander
Impact of HLA-B alleles, epitope binding affinity, functional avidity, and viral coinfection on the immunodominance of virus-specific CTL responses.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(7):4094-101.
2006: Javier Martinez-Picado; Julia G Prado; Elizabeth E Fry; Katja Pfafferott; Alasdair Leslie; Senica Chetty; Christina Thobakgale; Isobella Honeyborne; Hayley Crawford; Philippa Matthews; Tilly Pillay; Christine M Rousseau; James I Mullins; Christian Brander; Bruce D Walker; David I Stuart; Photini Kiepiela; Philip J R Goulder
Fitness cost of escape mutations in p24 Gag in association with control of human immunodeficiency virus type 1.
Journal of virology 2006;80(7):3617-23.
2006: Sigall Kassutto; Kaveh Maghsoudi; Mary N Johnston; Gregory Robbins; Nicole C Burgett; Paul E Sax; Daniel Cohen; Eunice Pae; Ben Davis; Kimon Zachary; Nesli Basgoz; Erika M C D'Agata; Victor DeGruttola; Bruce D Walker; Eric S Rosenberg
Longitudinal analysis of clinical markers following antiretroviral therapy initiated during acute or early HIV type 1 infection.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2006;42(7):1024-31.
2006: Rika Draenert; Todd M Allen; Yang Liu; Terri Wrin; Colombe Chappey; Cori L Verrill; Guillem Sirera; Robert L Eldridge; Matthew P Lahaie; Lidia Ruiz; Bonaventura Clotet; Christos J Petropoulos; Bruce D Walker; Javier Martinez-Picado
Constraints on HIV-1 evolution and immunodominance revealed in monozygotic adult twins infected with the same virus.
The Journal of experimental medicine 2006;203(3):529-39.
2006: Dirk Meyer-Olson; Kristen W Brady; Melissa T Bartman; Kristin M O'Sullivan; Brenna C Simons; Joseph Conrad; Coley B Duncan; Shelly Lorey; Atif Siddique; Rika Draenert; Marylyn M Addo; Marcus Altfeld; Eric Rosenberg; Todd M Allen; Bruce D Walker; Spyros A Kalams
Fluctuations of functionally distinct CD8+ T-cell clonotypes demonstrate flexibility of the HIV-specific TCR repertoire.
Blood 2006;107(6):2373-83.
2006: Rosario Zuñiga; Aldo Lucchetti; Patricia Galvan; Shyla Sanchez; Carmen Sanchez; Ana Hernandez; Hugo Sanchez; Nicole Frahm; Caitlyn H Linde; Hannah S Hewitt; William H Hildebrand; Marcus Altfeld; Todd M Allen; Bruce D Walker; Bette T Korber; Thomas Leitner; Jorge Sanchez; Christian Brander
Relative dominance of Gag p24-specific cytotoxic T lymphocytes is associated with human immunodeficiency virus control.
Journal of virology 2006;80(6):3122-5.
2006: Daniel G Kavanagh; Daniel E Kaufmann; Sherzana Sunderji; Nicole Frahm; Sylvie Le Gall; David Boczkowski; Eric S Rosenberg; David R Stone; Mary N Johnston; Bradford S Wagner; M Tauheed Zaman; Christian Brander; Eli Gilboa; Bruce D Walker; Nina Bhardwaj
Expansion of HIV-specific CD4+ and CD8+ T cells by dendritic cells transfected with mRNA encoding cytoplasm- or lysosome-targeted Nef.
Blood 2006;107(5):1963-9.
2006: Philip J Norris; Jennifer D Stone; Nadezhda Anikeeva; John W Heitman; Ingrid C Wilson; Dale F Hirschkorn; Margaret J Clark; Howell F Moffett; Thomas O Cameron; Yuri Sykulev; Lawrence J Stern; Bruce D Walker
Antagonism of HIV-specific CD4+ T cells by C-terminal truncation of a minimum epitope.
Molecular immunology 2006;43(9):1349-57.
2006: Nicole Frahm; Photini Kiepiela; Sharon Adams; Caitlyn H Linde; Hannah S Hewitt; Kaori Sango; Margaret E Feeney; Marylyn M Addo; Mathias Lichterfeld; Matthew P Lahaie; Eunice Pae; Alysse Wurcel; Timothy Roach; M Anne St John; Marcus Altfeld; Francesco M Marincola; Corey Moore; Simon Mallal; Mary Carrington; David Heckerman; Todd M Allen; James I Mullins; Bette T Korber; Philip J R Goulder; Bruce D Walker; Christian Brander
Control of human immunodeficiency virus replication by cytotoxic T lymphocytes targeting subdominant epitopes.
Nature immunology 2006;7(2):173-8.
2006: Mark Alan Brockman; Giancarlo O Tanzi; Bruce D Walker; Todd M Allen
Use of a novel GFP reporter cell line to examine replication capacity of CXCR4- and CCR5-tropic HIV-1 by flow cytometry.
Journal of virological methods 2006;131(2):134-42.
2005: Todd M Allen; Marcus Altfeld; Shaun C Geer; Elizabeth T Kalife; Corey Moore; Kristin M O'Sullivan; Ivna Desouza; Margaret E Feeney; Robert L Eldridge; Erica L Maier; Daniel E Kaufmann; Matthew P Lahaie; Laura L Reyor; Giancarlo O Tanzi; Mary N Johnston; Christian Brander; Rika Draenert; Jürgen K Rockstroh; Heiko Jessen; Eric S Rosenberg; Simon Mallal; Bruce D Walker
Selective escape from CD8+ T-cell responses represents a major driving force of human immunodeficiency virus type 1 (HIV-1) sequence diversity and reveals constraints on HIV-1 evolution.
Journal of virology 2005;79(21):13239-49.
2005: Tonia Woodberry; Todd J Suscovich; Leah M Henry; Jennifer K Davis; Nicole Frahm; Bruce D Walker; David T Scadden; Frederick Wang; Christian Brander
Differential targeting and shifts in the immunodominance of Epstein-Barr virus--specific CD8 and CD4 T cell responses during acute and persistent infection.
The Journal of infectious diseases 2005;192(9):1513-24.
2005: Georg M Lauer; Michaela Lucas; Joerg Timm; Kei Ouchi; Arthur Y Kim; Cheryl L Day; julian schulze zur wiesch; Glaucia Paranhos-Baccala; Isabelle Sheridan; Deborah R Casson; Markus Reiser; Rajesh T Gandhi; Bin Li; Todd M Allen; Raymond T Chung; Paul Klenerman; Bruce D Walker
Full-breadth analysis of CD8+ T-cell responses in acute hepatitis C virus infection and early therapy.
Journal of virology 2005;79(20):12979-88.
2005: Todd M Allen; Xu G Yu; Elizabeth T Kalife; Laura L Reyor; Mathias Lichterfeld; Mina John; Michael Cheng; Rachel L Allgaier; Stanley K Mui; Nicole Frahm; Galit Alter; Nancy V Brown; Mary N Johnston; Eric S Rosenberg; Simon Mallal; Christian Brander; Bruce D Walker; Marcus Altfeld
De novo generation of escape variant-specific CD8+ T-cell responses following cytotoxic T-lymphocyte escape in chronic human immunodeficiency virus type 1 infection.
Journal of virology 2005;79(20):12952-60.
2005: Xu G Yu; Mathias Lichterfeld; Beth Perkins; Elizabeth Kalife; Stanley K Mui; Jianping Chen; Michael Cheng; Wenzhen Kang; Galit Alter; Christian Brander; Bruce D Walker; Marcus Altfeld
High degree of inter-clade cross-reactivity of HIV-1-specific T cell responses at the single peptide level.
AIDS (London, England) 2005;19(14):1449-56.
2005: julian schulze zur wiesch; Georg M Lauer; Cheryl L Day; Arthur Y Kim; Kei Ouchi; Jared E Duncan; Alysse Wurcel; Joerg Timm; Andrea M Jones; Bianca R Mothe; Todd M Allen; Barbara McGovern; Lia L Lewis-Ximenez; John Sidney; Alessandro Sette; Raymond T Chung; Bruce D Walker
Broad repertoire of the CD4+ Th cell response in spontaneously controlled hepatitis C virus infection includes dominant and highly promiscuous epitopes.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(6):3603-13.
2005: John J Zaunders; Mee Ling Munier; Daniel E Kaufmann; Susanna Ip; Pat Grey; Don Smith; Tim Ramacciotti; Dick Quan; Robert Finlayson; John Kaldor; Eric S Rosenberg; Bruce D Walker; David A Cooper; Anthony D Kelleher
Early proliferation of CCR5(+) CD38(+++) antigen-specific CD4(+) Th1 effector cells during primary HIV-1 infection.
Blood 2005;106(5):1660-7.
2005: Tonia Woodberry; Todd J Suscovich; Leah M Henry; Jeffrey N Martin; Sheila Dollard; Paula G O'Connor; Jennifer K Davis; Dennis H Osmond; Tzong-Hae Lee; Dean H Kedes; Ashok Khatri; Jeannette Lee; Bruce D Walker; David T Scadden; Christian Brander
Impact of Kaposi sarcoma-associated herpesvirus (KSHV) burden and HIV coinfection on the detection of T cell responses to KSHV ORF73 and ORF65 proteins.
The Journal of infectious diseases 2005;192(4):622-9.
2005: Nicole Frahm; Sharon Adams; Photini Kiepiela; Caitlyn H Linde; Hannah S Hewitt; Mathias Lichterfeld; Kaori Sango; Nancy V Brown; Eunice Pae; Alysse Wurcel; Marcus Altfeld; Margaret E Feeney; Todd M Allen; Timothy Roach; M Anne St John; Eric S Daar; Eric Rosenberg; Bette Korber; Francesco M Marincola; Bruce D Walker; Philip J R Goulder; Christian Brander
HLA-B63 presents HLA-B57/B58-restricted cytotoxic T-lymphocyte epitopes and is associated with low human immunodeficiency virus load.
Journal of virology 2005;79(16):10218-25.
2005: William Rodriguez; Nicolaos Christodoulides; Pierre N Floriano; Susan Marie Graham; Sanghamitra Mohanty; Meredith Dixon; Mina Hsiang; Trevor Peter; Shabnam Zavahir; Ibou Thior; Dwight Romanovicz; Bruce Bernard; Adrian P Goodey; Bruce D Walker; John T McDevitt
A microchip CD4 counting method for HIV monitoring in resource-poor settings.
PLoS medicine 2005;2(7):e182.
2005: Tomohiko Koibuchi; Todd M Allen; Mathias Lichterfeld; Stanley K Mui; Kristin M O'Sullivan; Alicja Trocha; Spyros A Kalams; R Paul Johnson; Bruce D Walker
Limited sequence evolution within persistently targeted CD8 epitopes in chronic human immunodeficiency virus type 1 infection.
Journal of virology 2005;79(13):8171-81.
2005: Margaret E Feeney; Yanhua Tang; Katja Pfafferott; Kathleen A Roosevelt; Rika Draenert; Alicja Trocha; Xu G Yu; Cori L Verrill; Todd Allen; Corey Moore; Simon Mallal; Sandra K Burchett; Kenneth McIntosh; Stephen I Pelton; M Anne St John; Rohan Hazra; Paul Klenerman; Marcus Altfeld; Bruce D Walker; Philip J R Goulder
HIV-1 viral escape in infancy followed by emergence of a variant-specific CTL response.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(12):7524-30.
2005: Shawn M Sumida; Diana M Truitt; Angelique A C Lemckert; Ronald Vogels; Jerome H H V Custers; Marylyn M Addo; Shahin Lockman; Trevor Peter; Fred W Peyerl; Michael G Kishko; Shawn S Jackson; Darci A Gorgone; Michelle A Lifton; Myron Essex; Bruce D Walker; Jaap Goudsmit; Menzo J E Havenga; Dan H Barouch
Neutralizing antibodies to adenovirus serotype 5 vaccine vectors are directed primarily against the adenovirus hexon protein.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(11):7179-85.
2005: Marcus Altfeld; Todd M Allen; Elizabeth T Kalife; Nicole Frahm; Marylyn M Addo; Bianca R Mothe; Almas Rathod; Laura L Reyor; Jason Harlow; Xu G Yu; Beth Perkins; Loren K Robinson; John Sidney; Galit Alter; Mathias Lichterfeld; Alessandro Sette; Eric S Rosenberg; Philip J R Goulder; Christian Brander; Bruce D Walker
The majority of currently circulating human immunodeficiency virus type 1 clade B viruses fail to prime cytotoxic T-lymphocyte responses against an otherwise immunodominant HLA-A2-restricted epitope: implications for vaccine design.
Journal of virology 2005;79(8):5000-5.
2005: Arthur Y Kim; Georg M Lauer; Kei Ouchi; Marylyn M Addo; Michaela Lucas; julian schulze zur wiesch; Joerg Timm; Melinda Boczanowski; Jared E Duncan; Alysse Wurcel; Deborah R Casson; Raymond T Chung; Rika Draenert; Paul Klenerman; Bruce D Walker
The magnitude and breadth of hepatitis C virus-specific CD8+ T cells depend on absolute CD4+ T-cell count in individuals coinfected with HIV-1.
Blood 2005;105(3):1170-8.
2004: Joerg Timm; Georg M Lauer; Daniel G Kavanagh; Isabelle Sheridan; Arthur Y Kim; Michaela Lucas; Tilly Pillay; Kei Ouchi; Laura L Reyor; julian schulze zur wiesch; Rajesh T Gandhi; Raymond T Chung; Nina Bhardwaj; Paul Klenerman; Bruce D Walker; Todd M Allen
CD8 epitope escape and reversion in acute HCV infection.
The Journal of experimental medicine 2004;200(12):1593-604.
2004: Photini Kiepiela; Alasdair Leslie; Isobella Honeyborne; Danni Ramduth; Christina Thobakgale; Senica Chetty; Prinisha Rathnavalu; Corey Moore; Katja Pfafferott; Louise Hilton; Peter Zimbwa; Sarah Moore; Todd Allen; Christian Brander; Marylyn M Addo; Marcus Altfeld; Ian James; Simon Mallal; Mike Bunce; Linda D Barber; James Szinger; Cheryl Day; Paul Klenerman; James Mullins; Bette Korber; Hoosen M Coovadia; Bruce D Walker; Philip J R Goulder
Dominant influence of HLA-B in mediating the potential co-evolution of HIV and HLA.
Nature 2004;432(7018):769-75.
2004: Tatiana Lebedeva; Nadja Anikeeva; Spyros A Kalams; Bruce D Walker; Ibragim Gaidarov; James H Keen; Yuri Sykulev
Major histocompatibility complex class I-intercellular adhesion molecule-1 association on the surface of target cells: implications for antigen presentation to cytotoxic T lymphocytes.
Immunology 2004;113(4):460-71.
2004: Christoph Hess; Terry K Means; Patrick Autissier; Tonia Woodberry; Marcus Altfeld; Marylyn M Addo; Nicole Frahm; Christian Brander; Bruce D Walker; Andrew D Luster
IL-8 responsiveness defines a subset of CD8 T cells poised to kill.
Blood 2004;104(12):3463-71.
2004: Daniel E Kaufmann; Mathias Lichterfeld; Marcus Altfeld; Marylyn M Addo; Mary N Johnston; Paul K Lee; Bradford S Wagner; Elizabeth T Kalife; Daryld Strick; Eric S Rosenberg; Bruce D Walker
Limited durability of viral control following treated acute HIV infection.
PLoS medicine 2004;1(2):e36.
2004: Mathias Lichterfeld; Daniel E Kaufmann; Xu G Yu; Stanley K Mui; Marylyn M Addo; Mary N Johnston; Daniel Cohen; Gregory Robbins; Eunice Pae; Galit Alter; Alysse Wurcel; David Stone; Eric S Rosenberg; Bruce D Walker; Marcus Altfeld
Loss of HIV-1-specific CD8+ T cell proliferation after acute HIV-1 infection and restoration by vaccine-induced HIV-1-specific CD4+ T cells.
The Journal of experimental medicine 2004;200(6):701-12.
2004: Zarixia Zavala-Ruiz; Iwona Strug; Bruce D Walker; Philip J Norris; Lawrence J Stern
A hairpin turn in a class II MHC-bound peptide orients residues outside the binding groove for T cell recognition.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(36):13279-84.
2004: Georg M Lauer; Eleanor Barnes; Michaela Lucas; Joerg Timm; Kei Ouchi; Arthur Y Kim; Cheryl L Day; Gregory Robbins; Deborah R Casson; Markus Reiser; Geoffrey Dusheiko; Todd M Allen; Raymond T Chung; Bruce D Walker; Paul Klenerman
High resolution analysis of cellular immune responses in resolved and persistent hepatitis C virus infection.
Gastroenterology 2004;127(3):924-36.
2004: Margaret E Feeney; Yanhua Tang; Kathleen A Roosevelt; Alasdair Leslie; Kenneth McIntosh; N Karthas; Bruce D Walker; Philip J R Goulder
Immune escape precedes breakthrough human immunodeficiency virus type 1 viremia and broadening of the cytotoxic T-lymphocyte response in an HLA-B27-positive long-term-nonprogressing child.
Journal of virology 2004;78(16):8927-30.
2004: Devi SenGupta; Philip J Norris; Todd J Suscovich; Mina Hassan-Zahraee; Howell F Moffett; Alicja Trocha; Rika Draenert; Philip J R Goulder; Robert J Binder; Daniel L Levey; Bruce D Walker; Pramod K Srivastava; Christian Brander
Heat shock protein-mediated cross-presentation of exogenous HIV antigen on HLA class I and class II.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(3):1987-93.
2004: Mathias Lichterfeld; Xu G Yu; Michael T Waring; Stanley K Mui; Mary N Johnston; Daniel Cohen; Marylyn M Addo; John J Zaunders; Galit Alter; Eunice Pae; Daryld Strick; Todd M Allen; Eric S Rosenberg; Bruce D Walker; Marcus Altfeld
HIV-1-specific cytotoxicity is preferentially mediated by a subset of CD8(+) T cells producing both interferon-gamma and tumor necrosis factor-alpha.
Blood 2004;104(2):487-94.
2004: Mathias Lichterfeld; Xu G Yu; Daniel Cohen; Marylyn M Addo; Jessica M Malenfant; Beth Perkins; Eunice Pae; Mary N Johnston; Daryld Strick; Todd M Allen; Eric S Rosenberg; Bette Korber; Bruce D Walker; Marcus Altfeld
HIV-1 Nef is preferentially recognized by CD8 T cells in primary HIV-1 infection despite a relatively high degree of genetic diversity.
AIDS (London, England) 2004;18(10):1383-92.
2004: Todd M Allen; Marcus Altfeld; Xu G Yu; Kristin M O'Sullivan; Mathias Lichterfeld; Sylvie Le Gall; Mina John; Bianca R Mothe; Paul K Lee; Elizabeth T Kalife; Daniel E Cohen; Kenneth A Freedberg; Daryld Strick; Mary N Johnston; Alessandro Sette; Eric S Rosenberg; Simon Mallal; Philip J R Goulder; Christian Brander; Bruce D Walker
Selection, transmission, and reversion of an antigen-processing cytotoxic T-lymphocyte escape mutation in human immunodeficiency virus type 1 infection.
Journal of virology 2004;78(13):7069-78.
2004: Todd J Suscovich; Mini Paulose-Murphy; Jason Harlow; Yidong Chen; Seddon Y Thomas; Tiffany Mellott; Bruce D Walker; David T Scadden; Steven L Zeichner; Christian Brander
Defective immune function of primary effusion lymphoma cells is associated with distinct KSHV gene expression profiles.
Leukemia & lymphoma 2004;45(6):1223-38.
2004: Xu G Yu; Marylyn M Addo; Beth A Perkins; Feili Wej; Almas Rathod; Shaun C Geer; Mark Parta; Daniel Cohen; David R Stone; Christopher J Russell; Giancarlo O Tanzi; Shan Mei; Alysse Wurcel; Nicole Frahm; Mathias Lichterfeld; Laura Heath; James I Mullins; Francesco M Marincola; Philip J R Goulder; Christian Brander; Todd Allen; Yunzhen Cao; Bruce D Walker; Marcus Altfeld
Differences in the expressed HLA class I alleles effect the differential clustering of HIV type 1-specific T cell responses in infected Chinese and caucasians.
AIDS research and human retroviruses 2004;20(5):557-64.
2004: Diana M Brainard; William G Tharp; Elva Granado; Nicholas Miller; Alicja Trocha; Xiang-Hui Ren; Brian Conrad; Ernest F Terwilliger; Richard Wyatt; Bruce D Walker; Mark C Poznansky
Migration of antigen-specific T cells away from CXCR4-binding human immunodeficiency virus type 1 gp120.
Journal of virology 2004;78(10):5184-93.
2004: Daniel E Kaufmann; Paul M Bailey; John Sidney; Bradford Wagner; Philip J Norris; Mary N Johnston; Lisa A Cosimi; Marylyn M Addo; Mathias Lichterfeld; Marcus Altfeld; Nicole Frahm; Christian Brander; Alessandro Sette; Bruce D Walker; Eric S Rosenberg
Comprehensive analysis of human immunodeficiency virus type 1-specific CD4 responses reveals marked immunodominance of gag and nef and the presence of broadly recognized peptides.
Journal of virology 2004;78(9):4463-77.
2004: Rika Draenert; Christian Brander; Xu G Yu; Marcus Altfeld; Cori L Verrill; Margaret E Feeney; Bruce D Walker; Philip J R Goulder
Impact of intrapeptide epitope location on CD8 T cell recognition: implications for design of overlapping peptide panels.
AIDS (London, England) 2004;18(6):871-6.
2004: Rika Draenert; Sylvie Le Gall; Katja Pfafferott; Alasdair Leslie; Polan Chetty; Christian Brander; Edward C Holmes; Shih-Chung Chang; Margaret E Feeney; Marylyn M Addo; Lidia Ruiz; Danni Ramduth; Prakash Jeena; Marcus Altfeld; Stephanie Thomas; Yanhua Tang; Cori L Verrill; Catherine Dixon; Julia G Prado; Photini Kiepiela; Javier Martinez-Picado; Bruce D Walker; Philip J R Goulder
Immune selection for altered antigen processing leads to cytotoxic T lymphocyte escape in chronic HIV-1 infection.
The Journal of experimental medicine 2004;199(7):905-15.
2004: Christoph Hess; Marcus Altfeld; Seddon Y Thomas; Marylyn M Addo; Eric S Rosenberg; Todd M Allen; Rika Draenert; Robert L Eldrige; Jan van Lunzen; Hans-J Stellbrink; Bruce D Walker; Andrew D Luster
HIV-1 specific CD8+ T cells with an effector phenotype and control of viral replication.
Lancet 2004;363(9412):863-6.
2004: Philip J Norris; Howell F Moffett; Christian Brander; Todd M Allen; Kristin M O'Sullivan; Lisa A Cosimi; Daniel E Kaufmann; Bruce D Walker; Eric S Rosenberg
Fine specificity and cross-clade reactivity of HIV type 1 Gag-specific CD4+ T cells.
AIDS research and human retroviruses 2004;20(3):315-25.
2004: Nicole Frahm; Bette T Korber; C M Adams; James Szinger; Rika Draenert; Marylyn M Addo; Margaret E Feeney; Karina Yusim; Kaori Sango; Nancy V Brown; D SenGupta; A Piechocka-Trocha; T Simonis; Francesco M Marincola; Alysse Wurcel; David R Stone; Christopher J Russell; P Adolf; Daniel Cohen; Timothy Roach; A StJohn; Ashok Khatri; K Davis; James Mullins; Philip J R Goulder; Bruce D Walker; Christian Brander
Consistent cytotoxic-T-lymphocyte targeting of immunodominant regions in human immunodeficiency virus across multiple ethnicities.
Journal of virology 2004;78(5):2187-200.
2004: Alasdair Leslie; Katja Pfafferott; Polan Chetty; Rika Draenert; Marylyn M Addo; Margaret E Feeney; Yanhua Tang; Edward C Holmes; Todd Allen; Julia G Prado; Marcus Altfeld; Christian Brander; C Dixon; Danni Ramduth; Prakash Jeena; S A Thomas; A St John; Timothy Roach; B Kupfer; Graz Luzzi; Anne Edwards; G Taylor; Hermione Lyall; Gareth Tudor-Williams; Vas Novelli; Javier Martinez-Picado; Photini Kiepiela; Bruce D Walker; Philip J R Goulder
HIV evolution: CTL escape mutation and reversion after transmission.
Nature medicine 2004;10(3):282-9.
2004: Michaela Lucas; Ana L Vargas Cuero; Georg M Lauer; Eleanor Barnes; Christian B Willberg; Nasser Semmo; Bruce D Walker; Rodney Phillips; Paul Klenerman
Pervasive influence of hepatitis C virus on the phenotype of antiviral CD8+ T cells.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(3):1744-53.
2004: Rika Draenert; Cori L Verrill; Yanhua Tang; Todd M Allen; Alysse Wurcel; Melinda Boczanowski; Andreas Lechner; Arthur Y Kim; Todd J Suscovich; Nancy V Brown; Marylyn M Addo; Bruce D Walker
Persistent recognition of autologous virus by high-avidity CD8 T cells in chronic, progressive human immunodeficiency virus type 1 infection.
Journal of virology 2004;78(2):630-41.
2003: Cheryl L Day; Bruce D Walker
Progress in defining CD4 helper cell responses in chronic viral infections.
The Journal of experimental medicine 2003;198(12):1773-7.
2003: Margaret E Feeney; Rika Draenert; Kathleen A Roosevelt; Stephen I Pelton; Kenneth McIntosh; Sandra K Burchett; Charlotte Mao; Bruce D Walker; Philip J R Goulder
Reconstitution of virus-specific CD4 proliferative responses in pediatric HIV-1 infection.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(12):6968-75.
2003: Marcus Altfeld; Marylyn M Addo; Eric S Rosenberg; Frederick Hecht; Paul K Lee; Martin Vogel; Xu G Yu; Rika Draenert; Mary N Johnston; Daryld Strick; Todd M Allen; Margaret E Feeney; James O Kahn; Rafick-Pierre Sekaly; Jay A Levy; Jürgen K Rockstroh; Philip J R Goulder; Bruce D Walker
Influence of HLA-B57 on clinical presentation and viral control during acute HIV-1 infection.
AIDS (London, England) 2003;17(18):2581-91.
2003: Christian Brander; Bruce D Walker
Gradual adaptation of HIV to human host populations: good or bad news?
Nature medicine 2003;9(11):1359-62.
2003: Julio C Delgado; Jessica Y Leung; Andres Baena; Olga P Clavijo; Eric Vittinghoff; Susan Buchbinder; Steven Wolinsky; Marilynn Addo; Bruce D Walker; Edmond J Yunis; Anne E Goldfeld
The -1030/-862-linked TNF promoter single-nucleotide polymorphisms are associated with the inability to control HIV-1 viremia.
Immunogenetics 2003;55(7):497-501.
2003: Otto O Yang; Phuong Thi Nguyen Sarkis; Alicja Trocha; Spyros A Kalams; R Paul Johnson; Bruce D Walker
Impacts of avidity and specificity on the antiviral efficiency of HIV-1-specific CTL.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(7):3718-24.
2003: Cheryl L Day; Nilufer P Seth; Michaela Lucas; Heiner Appel; Laurent Gauthier; Georg M Lauer; Gregory Robbins; Zbigniew M Szczepiorkowski; Deborah R Casson; Raymond T Chung; Shannon Bell; Gillian Harcourt; Bruce D Walker; Paul Klenerman; Kai W Wucherpfennig
Ex vivo analysis of human memory CD4 T cells specific for hepatitis C virus using MHC class II tetramers.
The Journal of clinical investigation 2003;112(6):831-42.
2003: Margaret E Feeney; Kathleen A Roosevelt; Yanhua Tang; Katja Pfafferott; Kenneth McIntosh; Sandra K Burchett; C Mao; Bruce D Walker; Philip J R Goulder
Comprehensive screening reveals strong and broadly directed human immunodeficiency virus type 1-specific CD8 responses in perinatally infected children.
Journal of virology 2003;77(13):7492-501.
2003: Marcus Altfeld; Marylyn M Addo; Raj Shankarappa; Paul K Lee; Todd M Allen; Xu G Yu; Almas Rathod; Jason Harlow; Kristin M O'Sullivan; Mary N Johnston; Philip J R Goulder; James I Mullins; Eric S Rosenberg; Christian Brander; Bette Korber; Bruce D Walker
Enhanced detection of human immunodeficiency virus type 1-specific T-cell responses to highly variable regions by using peptides based on autologous virus sequences.
Journal of virology 2003;77(13):7330-40.
2003: Ma Somsouk; Georg M Lauer; Deborah R Casson; Adam Terella; Cheryl L Day; Bruce D Walker; Raymond T Chung
Spontaneous resolution of chronic hepatitis C virus disease after withdrawal of immunosuppression.
Gastroenterology 2003;124(7):1946-9.
2003: Gregory Robbins; Marylyn M Addo; Hien Troung; Almas Rathod; Kathy Habeeb; Benjamin Davis; Howard Heller; Nesli Basgoz; Bruce D Walker; Eric S Rosenberg
Augmentation of HIV-1-specific T helper cell responses in chronic HIV-1 infection by therapeutic immunization.
AIDS (London, England) 2003;17(8):1121-6.
2003: Otto O Yang; Phuong Thi Nguyen Sarkis; Ayub Ali; Jason Harlow; Christian Brander; Spyros A Kalams; Bruce D Walker
Determinant of HIV-1 mutational escape from cytotoxic T lymphocytes.
The Journal of experimental medicine 2003;197(10):1365-75.
2003: Cécile L Tremblay; Jennifer L Hicks; Lorraine Sutton; Francoise Giguel; Theresa Flynn; Mary Johnston; Paul E Sax; Bruce D Walker; Martin S Hirsch; Eric S Rosenberg; Richard T D'Aquila
Antiretroviral resistance associated with supervised treatment interruptions in treated acute HIV infection.
AIDS (London, England) 2003;17(7):1086-9.
2003: Rika Draenert; Marcus Altfeld; Christian Brander; Nesli Basgoz; Colleen Corcoran; Alysse Wurcel; David R Stone; Spyros A Kalams; Alicja Trocha; Marylyn M Addo; Philip J R Goulder; Bruce D Walker
Comparison of overlapping peptide sets for detection of antiviral CD8 and CD4 T cell responses.
Journal of immunological methods 2003;275(1-2):19-29.
2003: David C Montefiori; Marcus Altfeld; Paul K Lee; Miroslawa Bilska; Jintao Zhou; Mary N Johnston; Feng Gao; Bruce D Walker; Eric S Rosenberg
Viremia control despite escape from a rapid and potent autologous neutralizing antibody response after therapy cessation in an HIV-1-infected individual.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(7):3906-14.
2003: Michael E Severino; Phuong Thi Nguyen Sarkis; Bruce D Walker; Otto O Yang
Chimeric immune receptor T cells bypass class I requirements and recognize multiple cell types relevant in HIV-1 infection.
Virology 2003;306(2):371-5.
2003: kevin bobbitt; Marylyn M Addo; Marcus Altfeld; Tracey M Filzen; Adewunmi A Onafuwa; Bruce D Walker; Kathleen L Collins
Rev activity determines sensitivity of HIV-1-infected primary T cells to CTL killing.
Immunity 2003;18(2):289-99.
2003: Marylyn M Addo; Xu G Yu; Almas Rathod; Daniel Cohen; Robert L Eldridge; Daryld Strick; Mary N Johnston; Colleen Corcoran; Alysse Wurcel; C A Fitzpatrick; Margaret E Feeney; William Rodriguez; Nesli Basgoz; Rika Draenert; David R Stone; Christian Brander; Philip J R Goulder; Eric S Rosenberg; Marcus Altfeld; Bruce D Walker
Comprehensive epitope analysis of human immunodeficiency virus type 1 (HIV-1)-specific T-cell responses directed against the entire expressed HIV-1 genome demonstrate broadly directed responses, but no correlation to viral load.
Journal of virology 2003;77(3):2081-92.
2003: Ralf Geiben-Lynn; Mischo Kursar; Nancy V Brown; Marylyn M Addo; Hungyi Shau; Judy Lieberman; Andrew D Luster; Bruce D Walker
HIV-1 antiviral activity of recombinant natural killer cell enhancing factors, NKEF-A and NKEF-B, members of the peroxiredoxin family.
The Journal of biological chemistry 2003;278(3):1569-74.
2002: Cheryl L Day; Georg M Lauer; Gregory Robbins; Barbara McGovern; Alysse Wurcel; Rajesh T Gandhi; Raymond T Chung; Bruce D Walker
Broad specificity of virus-specific CD4+ T-helper-cell responses in resolved hepatitis C virus infection.
Journal of virology 2002;76(24):12584-95.
2002: Marcus Altfeld; Todd M Allen; Xu G Yu; Mary N Johnston; Deepak Agrawal; Bette T Korber; David C Montefiori; David O'Connor; Benjamin T Davis; Paul K Lee; Erica L Maier; Jason Harlow; Philip J R Goulder; Christian Brander; Eric S Rosenberg; Bruce D Walker
HIV-1 superinfection despite broad CD8+ T-cell responses containing replication of the primary virus.
Nature 2002;420(6914):434-9.
2002: Ralf Geiben-Lynn; Nancy Brown; Bruce D Walker; Andrew D Luster
Purification of a modified form of bovine antithrombin III as an HIV-1 CD8+ T-cell antiviral factor.
The Journal of biological chemistry 2002;277(44):42352-7.
2002: Todd M Allen; Anthony D Kelleher; John J Zaunders; Bruce D Walker
STI and beyond: the prospects of boosting anti-HIV immune responses.
Trends in immunology 2002;23(9):456-60.
2002: Xu G Yu; Marylyn M Addo; Eric S Rosenberg; William Rodriguez; Paul K Lee; Cecily A Fitzpatrick; Mary N Johnston; Daryld Strick; Philip J R Goulder; Bruce D Walker; Marcus Altfeld
Consistent patterns in the development and immunodominance of human immunodeficiency virus type 1 (HIV-1)-specific CD8+ T-cell responses following acute HIV-1 infection.
Journal of virology 2002;76(17):8690-701.
2002: Rajesh T Gandhi; Bruce D Walker
Promises and pitfalls in the reconstitution of immunity in patients who have HIV-1 infection.
Current opinion in immunology 2002;14(4):487-94.
2002: Christian Brander; Noopur Raje; Paula G O'Connor; Faith Davies; Jennifer Davis; Darminder Chauhan; Teru Hideshima; Jeff Martin; Dennis H Osmond; Dean H Kedes; Bruce D Walker; David T Scadden; Kenneth C Anderson
Absence of biologically important Kaposi sarcoma-associated herpesvirus gene products and virus-specific cellular immune responses in multiple myeloma.
Blood 2002;100(2):698-700.
2002: Georg M Lauer; Kei Ouchi; Raymond T Chung; Tam N Nguyen; Cheryl L Day; Deborah R Purkis; Markus Reiser; Arthur Y Kim; Michaela Lucas; Paul Klenerman; Bruce D Walker
Comprehensive analysis of CD8(+)-T-cell responses against hepatitis C virus reveals multiple unpredicted specificities.
Journal of virology 2002;76(12):6104-13.
2002: Marylyn M Addo; Marcus Altfeld; Almas Rathod; Michelle Yu; Xu G Yu; Philip J R Goulder; Eric S Rosenberg; Bruce D Walker
HIV-1 Vpu represents a minor target for cytotoxic T lymphocytes in HIV-1-infection.
AIDS (London, England) 2002;16(7):1071-3.
2002: Otto O Yang; EDUARDO GARCIA-ZEPEDA; Bruce D Walker; Andrew D Luster
Monocyte chemoattractant protein-2 (CC chemokine ligand 8) inhibits replication of human immunodeficiency virus type 1 via CC chemokine receptor 5.
The Journal of infectious diseases 2002;185(8):1174-8.
2002: Marcus Altfeld; Jan van Lunzen; Nicole Frahm; Xu G Yu; Claus Schneider; Robert L Eldridge; Margaret E Feeney; Dirk Meyer-Olson; Hans-Jürgen Stellbrink; Bruce D Walker
Expansion of pre-existing, lymph node-localized CD8+ T cells during supervised treatment interruptions in chronic HIV-1 infection.
The Journal of clinical investigation 2002;109(6):837-43.
2002: Georg M Lauer; Tam N Nguyen; Cheryl L Day; Gregory Robbins; Theresa Flynn; Katherine McGowan; Eric S Rosenberg; Michaela Lucas; Paul Klenerman; Raymond T Chung; Bruce D Walker
Human immunodeficiency virus type 1-hepatitis C virus coinfection: intraindividual comparison of cellular immune responses against two persistent viruses.
Journal of virology 2002;76(6):2817-26.
2002: Xu G Yu; Hong Shang; Marylyn M Addo; Robert L Eldridge; Mary N Phillips; Margaret E Feeney; Daryld Strick; Christian Brander; Philip J R Goulder; Eric S Rosenberg; Bruce D Walker; Marcus Altfeld
Important contribution of p15 Gag-specific responses to the total Gag-specific CTL responses.
AIDS (London, England) 2002;16(3):321-8.
2002: Otto O Yang; Phuong Thi Nguyen; Spyros A Kalams; Tatyana Dorfman; Heinrich G Göttlinger; Sheila Stewart; Irvin S Y Chen; Steven Threlkeld; Bruce D Walker
Nef-mediated resistance of human immunodeficiency virus type 1 to antiviral cytotoxic T lymphocytes.
Journal of virology 2002;76(4):1626-31.
2002: Rajesh T Gandhi; Bruce D Walker
Immunologic control of HIV-1.
Annual review of medicine 2002;53():149-72.
2001: Philip J R Goulder; C Pasquier; Edward C Holmes; B Liang; Y Tang; J Izopet; K Saune; E S Rosenberg; S K Burchett; K McIntosh; M C N M Barnardo; M Bunce; Bruce D Walker; Christian Brander; Rodney E Phillips
Mother-to-child transmission of HIV infection and CTL escape through HLA-A2-SLYNTVATL epitope sequence variation.
Immunology letters 2001;79(1-2):109-16.
2001: David C Montefiori; T S Hill; H T Vo; Bruce D Walker; Eric S Rosenberg
Neutralizing antibodies associated with viremia control in a subset of individuals after treatment of acute human immunodeficiency virus type 1 infection.
Journal of virology 2001;75(21):10200-7.
2001: Philip J Norris; M Sumaroka; Christian Brander; Howell F Moffett; SL Boswell; T Nguyen; Yuri Sykulev; Bruce D Walker; Eric S Rosenberg
Multiple effector functions mediated by human immunodeficiency virus-specific CD4(+) T-cell clones.
Journal of virology 2001;75(20):9771-9.
2001: Marcus Altfeld; Marylyn M Addo; Robert L Eldridge; Xu G Yu; S Thomas; Ashok Khatri; Daryld Strick; Mary N Phillips; George B Cohen; Sabina A Islam; Spyros A Kalams; Christian Brander; Philip J R Goulder; Eric S Rosenberg; Bruce D Walker
Vpr is preferentially targeted by CTL during HIV-1 infection.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(5):2743-52.
2001: Ralf Geiben-Lynn; Mischo Kursar; Nancy V Brown; E L Kerr; Andrew D Luster; Bruce D Walker
Noncytolytic inhibition of X4 virus by bulk CD8(+) cells from human immunodeficiency virus type 1 (HIV-1)-infected persons and HIV-1-specific cytotoxic T lymphocytes is not mediated by beta-chemokines.
Journal of virology 2001;75(17):8306-16.
2001: Rochelle P Walensky; Eric S Rosenberg; Mary Jane Ferraro; Elena Losina; Bruce D Walker; Kenneth A Freedberg
Investigation of primary human immunodeficiency virus infection in patients who test positive for heterophile antibody.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2001;33(4):570-2.
2001: Marcus Altfeld; Bruce D Walker
Less is more? STI in acute and chronic HIV-1 infection.
Nature medicine 2001;7(8):881-4.
2001: Philip J R Goulder; Christian Brander; Yanhua Tang; C Tremblay; Robert A Colbert; Marylyn M Addo; Eric S Rosenberg; T Nguyen; R Allen; Alicja Trocha; Marcus Altfeld; S He; Mike Bunce; Robert Funkhouser; Stephen I Pelton; Sandra K Burchett; Kenneth McIntosh; Bette T Korber; Bruce D Walker
Evolution and transmission of stable CTL escape mutations in HIV infection.
Nature 2001;412(6844):334-8.
2001: Christian Brander; P O'Connor; Todd J Suscovich; Norman Jones; Y Lee; Dean H Kedes; Don Ganem; J Martin; Dennis H Osmond; S Southwood; Alessandro Sette; Bruce D Walker; David T Scadden
Definition of an optimal cytotoxic T lymphocyte epitope in the latently expressed Kaposi's sarcoma-associated herpesvirus kaposin protein.
The Journal of infectious diseases 2001;184(2):119-26.
2001: Cheryl L Day; AK Shea; Marcus Altfeld; Douglas P Olson; SP Buchbinder; Frederick Hecht; Eric S Rosenberg; Bruce D Walker; Spyros A Kalams
Relative dominance of epitope-specific cytotoxic T-lymphocyte responses in human immunodeficiency virus type 1-infected persons with shared HLA alleles.
Journal of virology 2001;75(14):6279-91.
2001: Bruce D Walker; Bette T Korber
Immune control of HIV: the obstacles of HLA and viral diversity.
Nature immunology 2001;2(6):473-5.
2001: Christian Brander; Ulrike B Matter-Reissmann; Norman Jones; Bruce D Walker; David H Sachs; Jörg D Seebach
Inhibition of human NK cell-mediated cytotoxicity by exposure to ammonium chloride.
Journal of immunological methods 2001;252(1-2):1-14.
2001: Pedro O Flores-Villanueva; Edmond J Yunis; Julio C Delgado; Eric Vittinghoff; Susan Buchbinder; Jessica Y Leung; AM Uglialoro; Olga P Clavijo; Eric S Rosenberg; Spyros A Kalams; J D Braun; SL Boswell; Bruce D Walker; Anne E Goldfeld
Control of HIV-1 viremia and protection from AIDS are associated with HLA-Bw4 homozygosity.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(9):5140-5.
2001: Marylyn M Addo; Marcus Altfeld; Eric S Rosenberg; Robert L Eldridge; M N Philips; K Habeeb; Ashok Khatri; Christian Brander; Gregory Robbins; G P Mazzara; Philip J R Goulder; Bruce D Walker
The HIV-1 regulatory proteins Tat and Rev are frequently targeted by cytotoxic T lymphocytes derived from HIV-1-infected individuals.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(4):1781-6.
2001: Philip J R Goulder; Marylyn M Addo; Marcus Altfeld; Eric S Rosenberg; Yanhua Tang; UG Govender; N Mngqundaniso; K Annamalai; T U Vogel; M Hammond; Mike Bunce; Hoosen M Coovadia; Bruce D Walker
Rapid definition of five novel HLA-A*3002-restricted human immunodeficiency virus-specific cytotoxic T-lymphocyte epitopes by elispot and intracellular cytokine staining assays.
Journal of virology 2001;75(3):1339-47.
2001: Marcus Altfeld; Brian D Livingston; N Reshamwala; Phuong Thi Nguyen; Marylyn M Addo; AK Shea; M Newman; John Fikes; John Sidney; PA Wentworth; Robert W Chesnut; Robert L Eldridge; Eric S Rosenberg; Gregory Robbins; Christian Brander; PE Sax; SL Boswell; Theresa Flynn; Susan Buchbinder; Philip J R Goulder; Bruce D Walker; Alessandro Sette; Spyros A Kalams
Identification of novel HLA-A2-restricted human immunodeficiency virus type 1-specific cytotoxic T-lymphocyte epitopes predicted by the HLA-A2 supertype peptide-binding motif.
Journal of virology 2001;75(3):1301-11.
2001: D K Wong; D D Dudley; P B Dohrenwend; Georg M Lauer; Raymond T Chung; David L Thomas; Bruce D Walker
Detection of diverse hepatitis C virus (HCV)-specific cytotoxic T lymphocytes in peripheral blood of infected persons by screening for responses to all translated proteins of HCV.
Journal of virology 2001;75(3):1229-35.
2001: Philip J R Goulder; Marcus Altfeld; Eric S Rosenberg; T Nguyen; Yanhua Tang; Robert L Eldridge; Marylyn M Addo; S He; Joia S Mukherjee; Mary N Phillips; Mike Bunce; Spyros A Kalams; Rafick-Pierre Sekaly; Bruce D Walker; Christian Brander
Substantial differences in specificity of HIV-specific cytotoxic T cells in acute and chronic HIV infection.
The Journal of experimental medicine 2001;193(2):181-94.
2001: Marcus Altfeld; Eric S Rosenberg; Raj Shankarappa; Joia S Mukherjee; Frederick Hecht; Robert L Eldridge; Marylyn M Addo; S H Poon; Mary N Phillips; Gregory Robbins; PE Sax; SL Boswell; James O Kahn; Christian Brander; Philip J R Goulder; J A Levy; James I Mullins; Bruce D Walker
Cellular immune responses and viral diversity in individuals treated during acute and early HIV-1 infection.
The Journal of experimental medicine 2001;193(2):169-80.
2000: Philip J R Goulder; Yanhua Tang; Christian Brander; M R Betts; Marcus Altfeld; K Annamalai; Alicja Trocha; S He; Eric S Rosenberg; GS Ogg; Christopher A O'Callaghan; Spyros A Kalams; R E McKinney; K Mayer; R A Koup; Stephen I Pelton; Sandra K Burchett; Kenneth McIntosh; Bruce D Walker
Functionally inert HIV-specific cytotoxic T lymphocytes do not play a major role in chronically infected adults and children.
The Journal of experimental medicine 2000;192(12):1819-32.
2000: Cécile L Tremblay; Françoise Giguel; DP Merrill; J T Wong; E Rosenberg; Spyros A Kalams; Bruce D Walker; Richard T D'Aquila; Martin S Hirsch
Marked differences in quantity of infectious human immunodeficiency virus type 1 detected in persons with controlled plasma viremia by a simple enhanced culture method.
Journal of clinical microbiology 2000;38(11):4246-8.
2000: H Cao; I Mani; R Vincent; Roy D Mugerwa; Peter Mugyenyi; Phyllis J Kanki; Jerrold Jay Ellner; Bruce D Walker
Cellular immunity to human immunodeficiency virus type 1 (HIV-1) clades: relevance to HIV-1 vaccine trials in Uganda.
The Journal of infectious diseases 2000;182(5):1350-6.
2000: Eric S Rosenberg; Marcus Altfeld; S H Poon; Mary N Phillips; BM Wilkes; Robert L Eldridge; Gregory Robbins; Richard T D'Aquila; Philip J R Goulder; Bruce D Walker
Immune control of HIV-1 after early treatment of acute infection.
Nature 2000;407(6803):523-6.
2000: Javier Martinez-Picado; M P DePasquale; N Kartsonis; George J Hanna; Joseph Wong; D Finzi; E Rosenberg; H F Gunthard; Lorraine Sutton; AV Savara; C J Petropoulos; N Hellmann; Bruce D Walker; Douglas D Richman; Robert Siliciano; Richard T D'Aquila
Antiretroviral resistance during successful therapy of HIV type 1 infection.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(20):10948-53.
2000: Marcus Altfeld; Alicja Trocha; Robert L Eldridge; Eric S Rosenberg; Mary N Phillips; Marylyn M Addo; Rafick-Pierre Sekaly; Spyros A Kalams; S A Burchett; Kenneth McIntosh; Bruce D Walker; Philip J R Goulder
Identification of dominant optimal HLA-B60- and HLA-B61-restricted cytotoxic T-lymphocyte (CTL) epitopes: rapid characterization of CTL responses by enzyme-linked immunospot assay.
Journal of virology 2000;74(18):8541-9.
2000: Christian Brander; Todd J Suscovich; Y Lee; Phuong Thi Nguyen; P O'Connor; Jörg D Seebach; Norman Jones; M van Gorder; Bruce D Walker; David T Scadden
Impaired CTL recognition of cells latently infected with Kaposi's sarcoma-associated herpes virus.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(4):2077-83.
2000: Philip J R Goulder; F Lechner; Paul Klenerman; Kenneth McIntosh; Bruce D Walker
Characterization of a novel respiratory syncytial virus-specific human cytotoxic T-lymphocyte epitope.
Journal of virology 2000;74(16):7694-7.
2000: Michael E Severino; NV Sipsas; Phuong Thi Nguyen; Spyros A Kalams; Bruce D Walker; R Paul Johnson; Otto O Yang
Inhibition of human immunodeficiency virus type 1 replication in primary CD4(+) T lymphocytes, monocytes, and dendritic cells by cytotoxic T lymphocytes.
Journal of virology 2000;74(14):6695-9.
2000: Philip J R Goulder; Christian Brander; K Annamalai; N Mngqundaniso; UG Govender; Yanhua Tang; S He; Kelly Hartman; Christopher A O'Callaghan; GS Ogg; Marcus Altfeld; Eric S Rosenberg; H Cao; Spyros A Kalams; M Hammond; Mike Bunce; Stephen I Pelton; S A Burchett; Kenneth McIntosh; Hoosen M Coovadia; Bruce D Walker
Differential narrow focusing of immunodominant human immunodeficiency virus gag-specific cytotoxic T-lymphocyte responses in infected African and caucasoid adults and children.
Journal of virology 2000;74(12):5679-90.
2000: Philip J R Goulder; Yanhua Tang; Stephen I Pelton; Bruce D Walker
HLA-B57-restricted cytotoxic T-lymphocyte activity in a single infected subject toward two optimal epitopes, one of which is entirely contained within the other.
Journal of virology 2000;74(11):5291-9.
2000: Franziska Lechner; D K Wong; P Rod Dunbar; R Chapman; R T Chung; P Dohrenwend; G Robbins; Rodney Phillips; Paul Klenerman; Bruce D Walker
Analysis of successful immune responses in persons infected with hepatitis C virus.
The Journal of experimental medicine 2000;191(9):1499-512.
2000: Bruce D Walker
Can immune responses to human immunodeficiency virus be preserved, enhanced, or restored?
AIDS clinical review 2000;():101-14.
1999: Christian Brander; Otto O Yang; Norman Jones; Y Lee; Philip J R Goulder; R Paul Johnson; Alicja Trocha; D Colbert; C Hay; Susan Buchbinder; C C Bergmann; H J Zweerink; Steven Wolinsky; William A Blattner; Spyros A Kalams; Bruce D Walker
Efficient processing of the immunodominant, HLA-A*0201-restricted human immunodeficiency virus type 1 cytotoxic T-lymphocyte epitope despite multiple variations in the epitope flanking sequences.
Journal of virology 1999;73(12):10191-8.
1999: Christian Brander; Bruce D Walker
T lymphocyte responses in HIV-1 infection: implications for vaccine development.
Current opinion in immunology 1999;11(4):451-9.
1999: Spyros A Kalams; Philip J R Goulder; AK Shea; Norman Jones; Alicja Trocha; GS Ogg; Bruce D Walker
Levels of human immunodeficiency virus type 1-specific cytotoxic T-lymphocyte effector and memory responses decline after suppression of viremia with highly active antiretroviral therapy.
Journal of virology 1999;73(8):6721-8.
1999: Spyros A Kalams; SP Buchbinder; Eric S Rosenberg; JM Billingsley; D S Colbert; Norman Jones; AK Shea; Alicja Trocha; Bruce D Walker
Association between virus-specific cytotoxic T-lymphocyte and helper responses in human immunodeficiency virus type 1 infection.
Journal of virology 1999;73(8):6715-20.
1999: C M Hay; DJ Ruhl; Nesli Basgoz; CC Wilson; JM Billingsley; M P DePasquale; Richard T D'Aquila; Steven Wolinsky; J M Crawford; David C Montefiori; Bruce D Walker
Lack of viral escape and defective in vivo activation of human immunodeficiency virus type 1-specific cytotoxic T lymphocytes in rapidly progressive infection.
Journal of virology 1999;73(7):5509-19.
1999: Otto O Yang; S L Swanberg; Z Lu; M Dziejman; J McCoy; Andrew D Luster; Bruce D Walker; SH Herrmann
Enhanced inhibition of human immunodeficiency virus type 1 by Met-stromal-derived factor 1beta correlates with down-modulation of CXCR4.
Journal of virology 1999;73(6):4582-9.
1999: CC Wilson; R C Brown; Bette T Korber; BM Wilkes; DJ Ruhl; D Sakamoto; Kevin Kunstman; Katherine Luzuriaga; I C Hanson; S M Widmayer; Andrew Wiznia; S Clapp; Arthur J Ammann; RA Koup; Steven Wolinsky; Bruce D Walker
Frequent detection of escape from cytotoxic T-lymphocyte recognition in perinatal human immunodeficiency virus (HIV) type 1 transmission: the ariel project for the prevention of transmission of HIV from mother to infant.
Journal of virology 1999;73(5):3975-85.
1999: Christian Brander; Philip J R Goulder; Katherine Luzuriaga; Otto O Yang; Kelly Hartman; Norman Jones; Bruce D Walker; Spyros A Kalams
Persistent HIV-1-specific CTL clonal expansion despite high viral burden post in utero HIV-1 infection.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(8):4796-800.
1999: E S Rosenberg; A M Caliendo; Bruce D Walker
Acute HIV infection among patients tested for mononucleosis.
The New England journal of medicine 1999;340(12):969.
1999: Allen Rodrigo; E G Shpaer; E L Delwart; A K Iversen; M V Gallo; Jurgen Brojatsch; M S Hirsch; Bruce D Walker; James I Mullins
Coalescent estimates of HIV-1 generation time in vivo.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(5):2187-91.
1999: Eric S Rosenberg; L LaRosa; Theresa Flynn; Gregory Robbins; Bruce D Walker
Characterization of HIV-1-specific T-helper cells in acute and chronic infection.
Immunology letters 1999;66(1-3):89-93.
1999: DP Merrill; Javier Martinez-Picado; Cécile L Tremblay; P E Sax; S L Boswell; J T Wong; Richard T D'Aquila; Bruce D Walker; Martin S Hirsch
Improved CD4 lymphocyte outgrowth in response to effective antiretroviral therapy.
The Journal of infectious diseases 1999;179(2):345-51.
1999: P J Goulder; S L Rowland-Jones; A J McMichael; Bruce D Walker
Anti-HIV cellular immunity: recent advances towards vaccine design.
AIDS (London, England) 1999;13 Suppl A():S121-36.
1998: Spyros A Kalams; Bruce D Walker
The critical need for CD4 help in maintaining effective cytotoxic T lymphocyte responses.
The Journal of experimental medicine 1998;188(12):2199-204.
1998: X Jin; C G Roberts; D F Nixon; Yunzhen Cao; David D Ho; Bruce D Walker; Mark Muldoon; Bette T Korber; RA Koup
Longitudinal and cross-sectional analysis of cytotoxic T lymphocyte responses and their relationship to vertical human immunodeficiency virus transmission. ARIEL Project Investigators.
The Journal of infectious diseases 1998;178(5):1317-26.
1998: Eric S Rosenberg; Bruce D Walker
HIV type 1-specific helper T cells: a critical host defense.
AIDS research and human retroviruses 1998;14 Suppl 2():S143-7.
1998: Christian Brander; Kelly Hartman; Alicja Trocha; Norman Jones; R Paul Johnson; Bette Korber; PA Wentworth; SP Buchbinder; Steven Wolinsky; Bruce D Walker; Spyros A Kalams
Lack of strong immune selection pressure by the immunodominant, HLA-A*0201-restricted cytotoxic T lymphocyte response in chronic human immunodeficiency virus-1 infection.
The Journal of clinical investigation 1998;101(11):2559-66.
1998: J B Walter; David N Garboczi; QR Fan; X Zhou; Bruce D Walker; Herman N Eisen
A mutant human beta2-microglobulin can be used to generate diverse multimeric class I peptide complexes as specific probes for T cell receptors.
Journal of immunological methods 1998;214(1-2):41-50.
1998: L Wagner; Otto O Yang; EDUARDO GARCIA-ZEPEDA; Y Ge; Spyros A Kalams; Bruce D Walker; Mark S Pasternack; Andrew D Luster
Beta-chemokines are released from HIV-1-specific cytolytic T-cell granules complexed to proteoglycans.
Nature 1998;391(6670):908-11.
1998: Kathleen L Collins; BK Chen; S A Kalams; Bruce D Walker; David Baltimore
HIV-1 Nef protein protects infected primary cells against killing by cytotoxic T lymphocytes.
Nature 1998;391(6665):397-401.
1997: Eric S Rosenberg; JM Billingsley; A M Caliendo; SL Boswell; PE Sax; Spyros A Kalams; Bruce D Walker
Vigorous HIV-1-specific CD4+ T cell responses associated with control of viremia.
Science (New York, N.Y.) 1997;278(5342):1447-50.
1997: H Cao; Phyllis J Kanki; Jean-louis Sankale; Abdoulaye Dieng Sarr; G P Mazzara; Spyros A Kalams; Bette Korber; Souleymane MBoup; Bruce D Walker
Cytotoxic T-lymphocyte cross-reactivity among different human immunodeficiency virus type 1 clades: implications for vaccine development.
Journal of virology 1997;71(11):8615-23.
1997: Otto O Yang; A C Tran; Spyros A Kalams; R Paul Johnson; M R Roberts; Bruce D Walker
Lysis of HIV-1-infected cells and inhibition of viral replication by universal receptor T cells.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(21):11478-83.
1997: Margaret James Koziel; D K Wong; D Dudley; M Houghton; Bruce D Walker
Hepatitis C virus-specific cytolytic T lymphocyte and T helper cell responses in seronegative persons.
The Journal of infectious diseases 1997;176(4):859-66.
1997: S C Threlkeld; PA Wentworth; Spyros A Kalams; BM Wilkes; DJ Ruhl; Elissa Keogh; John Sidney; Scott Southwood; Bruce D Walker; Alessandro Sette
Degenerate and promiscuous recognition by CTL of peptides presented by the MHC class I A3-like superfamily: implications for vaccine development.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(4):1648-57.
1997: Otto O Yang; Spyros A Kalams; Alicja Trocha; H Cao; Andrew D Luster; R Paul Johnson; Bruce D Walker
Suppression of human immunodeficiency virus type 1 replication by CD8+ cells: evidence for HLA class I-restricted triggering of cytolytic and noncytolytic mechanisms.
Journal of virology 1997;71(4):3120-8.
1997: J B Walter; C Brander; M Mammen; David N Garboczi; S A Kalams; G M Whitesides; Bruce D Walker; Herman N Eisen
Stimulation of human cytotoxic T cells with HIV-1-derived peptides presented by recombinant HLA-A2 peptide complexes.
International immunology 1997;9(3):451-9.
1997: NV Sipsas; Spyros A Kalams; Alicja Trocha; S He; William A Blattner; Bruce D Walker; R Paul Johnson
Identification of type-specific cytotoxic T lymphocyte responses to homologous viral proteins in laboratory workers accidentally infected with HIV-1.
The Journal of clinical investigation 1997;99(4):752-62.
1997: CC Wilson; Spyros A Kalams; BM Wilkes; DJ Ruhl; F Gao; B H Hahn; I C Hanson; Katherine Luzuriaga; Steven Wolinsky; RA Koup; SP Buchbinder; R Paul Johnson; Bruce D Walker
Overlapping epitopes in human immunodeficiency virus type 1 gp120 presented by HLA A, B, and C molecules: effects of viral variation on cytotoxic T-lymphocyte recognition.
Journal of virology 1997;71(2):1256-64.
1997: Otto O Yang; Bruce D Walker
CD8+ cells in human immunodeficiency virus type I pathogenesis: cytolytic and noncytolytic inhibition of viral replication.
Advances in immunology 1997;66():273-311.
1996: Otto O Yang; Spyros A Kalams; M Rosenzweig; Alicja Trocha; N Jones; Margaret James Koziel; Bruce D Walker; R Paul Johnson
Efficient lysis of human immunodeficiency virus type 1-infected cells by cytotoxic T lymphocytes.
Journal of virology 1996;70(9):5799-806.
1996: Thomas Harrer; Ellen G Harrer; Spyros A Kalams; Tarek Elbeik; Silvija I Staprans; Mark B Feinberg; Y Cao; D D Ho; Tilahun D Yilma; A M Caliendo; R Paul Johnson; S P Buchbinder; Bruce D Walker
Strong cytotoxic T cell and weak neutralizing antibody responses in a subset of persons with stable nonprogressing HIV type 1 infection.
AIDS research and human retroviruses 1996;12(7):585-92.
1996: Thomas Harrer; Ellen G Harrer; Spyros A Kalams; P Barbosa; Alicja Trocha; R Paul Johnson; Tarek Elbeik; Mark B Feinberg; S P Buchbinder; Bruce D Walker
Cytotoxic T lymphocytes in asymptomatic long-term nonprogressing HIV-1 infection. Breadth and specificity of the response and relation to in vivo viral quasispecies in a person with prolonged infection and low viral load.
Journal of immunology (Baltimore, Md. : 1950) 1996;156(7):2616-23.
1996: Spyros A Kalams; R Paul Johnson; M J Dynan; Kelly Hartman; Thomas Harrer; Ellen G Harrer; Alicja Trocha; William A Blattner; S P Buchbinder; Bruce D Walker
T cell receptor usage and fine specificity of human immunodeficiency virus 1-specific cytotoxic T lymphocyte clones: analysis of quasispecies recognition reveals a dominant response directed against a minor in vivo variant.
The Journal of experimental medicine 1996;183(4):1669-79.
1996: Ellen G Harrer; Thomas Harrer; P Barbosa; Mark B Feinberg; R Paul Johnson; S Buchbinder; Bruce D Walker
Recognition of the highly conserved YMDD region in the human immunodeficiency virus type 1 reverse transcriptase by HLA-A2-restricted cytotoxic T lymphocytes from an asymptomatic long-term nonprogressor.
The Journal of infectious diseases 1996;173(2):476-9.
1995: Martin Heinkelein; Jürgen Schneider-Schaulies; Bruce D Walker; Christian Jassoy
Inhibition of cytotoxicity and cytokine release of CD8+ HIV-specific cytotoxic T lymphocytes by pentoxifylline.
Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association 1995;10(4):417-24.
1995: Margaret James Koziel; D Dudley; N Afdhal; Arash Grakoui; C M Rice; Q L Choo; Michael Houghton; Bruce D Walker
HLA class I-restricted cytotoxic T lymphocytes specific for hepatitis C virus. Identification of multiple epitopes and characterization of patterns of cytokine release.
The Journal of clinical investigation 1995;96(5):2311-21.
1995: A K Iversen; E G Shpaer; Allen Rodrigo; M S Hirsch; Bruce D Walker; H W Sheppard; Thomas C Merigan; James I Mullins
Persistence of attenuated rev genes in a human immunodeficiency virus type 1-infected asymptomatic individual.
Journal of virology 1995;69(9):5743-53.
1995: Scott A Hammond; R Paul Johnson; S A Kalams; Bruce D Walker; M Takiguchi; J T Safrit; RA Koup; Robert Siliciano
An epitope-selective, transporter associated with antigen presentation (TAP)-1/2-independent pathway and a more general TAP-1/2-dependent antigen-processing pathway allow recognition of the HIV-1 envelope glycoprotein by CD8+ CTL.
Journal of immunology (Baltimore, Md. : 1950) 1995;154(11):6140-56.
1995: Christian Jassoy; Bruce D Walker
T lymphocytes and their cytokines in human immunodeficiency virus (HIV) infection: implications for associated neoplasias.
Critical reviews in oncogenesis 1995;6(3-6):275-89.
1995: Spyros A Kalams; Bruce D Walker
Cytotoxic T lymphocytes and HIV-1 related neurologic disorders.
Current topics in microbiology and immunology 1995;202():79-88.
1995: P Price; R Paul Johnson; David T Scadden; Christian Jassoy; T Rosenthal; Spyros A Kalams; Bruce D Walker
Cytotoxic CD8+ T lymphocytes reactive with human immunodeficiency virus-1 produce granulocyte/macrophage colony-stimulating factor and variable amounts of interleukins 2, 3, and 4 following stimulation with the cognate epitope.
Clinical immunology and immunopathology 1995;74(1):100-6.
1994: Christian Jassoy; Martin Heinkelein; Hartwig Klinker; Bruce D Walker
HIV type 1-specific cytotoxic T lymphocytes stimulate HLA class I and intercellular adhesion molecule type 1 expression and increase beta 2-microglobulin levels in vitro.
AIDS research and human retroviruses 1994;10(12):1685-93.
1994: Eric L Delwart; H W Sheppard; Bruce D Walker; J Goudsmit; James I Mullins
Human immunodeficiency virus type 1 evolution in vivo tracked by DNA heteroduplex mobility assays.
Journal of virology 1994;68(10):6672-83.
1994: T J Tsomides; A Aldovini; R P Johnson; Bruce D Walker; Richard A Young; Herman N Eisen
Naturally processed viral peptides recognized by cytotoxic T lymphocytes on cells chronically infected by human immunodeficiency virus type 1.
The Journal of experimental medicine 1994;180(4):1283-93.
1994: R Paul Johnson; Scott A Hammond; Alicja Trocha; Robert Siliciano; Bruce D Walker
Induction of a major histocompatibility complex class I-restricted cytotoxic T-lymphocyte response to a highly conserved region of human immunodeficiency virus type 1 (HIV-1) gp120 in seronegative humans immunized with a candidate HIV-1 vaccine.
Journal of virology 1994;68(5):3145-53.
1994: Spyros A Kalams; R Paul Johnson; Alicja Trocha; M J Dynan; H S Ngo; Richard T D'Aquila; J T Kurnick; Bruce D Walker
Longitudinal analysis of T cell receptor (TCR) gene usage by human immunodeficiency virus 1 envelope-specific cytotoxic T lymphocyte clones reveals a limited TCR repertoire.
The Journal of experimental medicine 1994;179(4):1261-71.
1994: Bruce D Walker
The rationale for immunotherapy in HIV-1 infection.
Journal of acquired immune deficiency syndromes 1994;7 Suppl 1():S6-13.
1994: Ellen G Harrer; Thomas Harrer; S Buchbinder; Dean L Mann; Mark B Feinberg; Tilahun D Yilma; R Paul Johnson; Bruce D Walker
HIV-1-specific cytotoxic T lymphocyte response in healthy, long-term nonprogressing seropositive persons.
AIDS research and human retroviruses 1994;10 Suppl 2():S77-8.
1994: R Paul Johnson; Scott A Hammond; Alicja Trocha; Robert Siliciano; Bruce D Walker
Epitope specificity of MHC restricted cytotoxic T lymphocytes induced by candidate HIV-1 vaccine.
AIDS research and human retroviruses 1994;10 Suppl 2():S73-5.
1994: R Paul Johnson; Bruce D Walker
Cytotoxic T lymphocytes in human immunodeficiency virus infection: responses to structural proteins.
Current topics in microbiology and immunology 1994;189():35-63.
1993: Margaret James Koziel; D Dudley; N Afdhal; Q L Choo; Michael Houghton; R Ralston; Bruce D Walker
Hepatitis C virus (HCV)-specific cytotoxic T lymphocytes recognize epitopes in the core and envelope proteins of HCV.
Journal of virology 1993;67(12):7522-32.
1993: Thomas Harrer; Christian Jassoy; Ellen G Harrer; R Paul Johnson; Bruce D Walker
Induction of HIV-1 replication in a chronically infected T-cell line by cytotoxic T lymphocytes.
Journal of acquired immune deficiency syndromes 1993;6(8):865-71.
1993: Christian Jassoy; Thomas Harrer; T Rosenthal; B A Navia; J Worth; R Paul Johnson; Bruce D Walker
Human immunodeficiency virus type 1-specific cytotoxic T lymphocytes release gamma interferon, tumor necrosis factor alpha (TNF-alpha), and TNF-beta when they encounter their target antigens.
Journal of virology 1993;67(5):2844-52.
1993: R Paul Johnson; Alicja Trocha; T M Buchanan; Bruce D Walker
Recognition of a highly conserved region of human immunodeficiency virus type 1 gp120 by an HLA-Cw4-restricted cytotoxic T-lymphocyte clone.
Journal of virology 1993;67(1):438-45.
1992: Margaret James Koziel; D Dudley; J T Wong; J Dienstag; Michael Houghton; R Ralston; Bruce D Walker
Intrahepatic cytotoxic T lymphocytes specific for hepatitis C virus in persons with chronic hepatitis.
Journal of immunology (Baltimore, Md. : 1950) 1992;149(10):3339-44.
1992: Christian Jassoy; R Paul Johnson; B A Navia; J Worth; Bruce D Walker
Detection of a vigorous HIV-1-specific cytotoxic T lymphocyte response in cerebrospinal fluid from infected persons with AIDS dementia complex.
Journal of immunology (Baltimore, Md. : 1950) 1992;149(9):3113-9.
1992: R Paul Johnson; Alicja Trocha; T M Buchanan; Bruce D Walker
Identification of overlapping HLA class I-restricted cytotoxic T cell epitopes in a conserved region of the human immunodeficiency virus type 1 envelope glycoprotein: definition of minimum epitopes and analysis of the effects of sequence variation.
The Journal of experimental medicine 1992;175(4):961-71.
1992: Margaret James Koziel; Bruce D Walker
Viruses, chemotherapy and immunity.
Parasitology 1992;105 Suppl():S85-92.
1991: T J Tsomides; Bruce D Walker; Herman N Eisen
An optimal viral peptide recognized by CD8+ T cells binds very tightly to the restricting class I major histocompatibility complex protein on intact cells but not to the purified class I protein.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(24):11276-80.
1991: R Paul Johnson; Alicja Trocha; L Yang; Gail P Mazzara; D L Panicali; T M Buchanan; Bruce D Walker
HIV-1 gag-specific cytotoxic T lymphocytes recognize multiple highly conserved epitopes. Fine specificity of the gag-specific response defined by using unstimulated peripheral blood mononuclear cells and cloned effector cells.
Journal of immunology (Baltimore, Md. : 1950) 1991;147(5):1512-21.
1991: R Paul Johnson; Bruce D Walker
Identification of HIV-1 cytotoxic T-lymphocyte epitopes and implications for vaccine development.
Biotechnology therapeutics 1991;2(1-2):137-46.
1990: Bruce D Walker; F Plata
Cytotoxic T lymphocytes against HIV.
AIDS (London, England) 1990;4(3):177-84.
1989: Bruce D Walker; Charles Flexner; K Birch-Limberger; L Fisher; T J Paradis; A Aldovini; R Young; Bernard Moss; R T Schooley
Long-term culture and fine specificity of human cytotoxic T-lymphocyte clones reactive with human immunodeficiency virus type 1.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(23):9514-8.
1989: Victoria A Johnson; M A Barlow; Ting-Chao Chou; R A Fisher; Bruce D Walker; Martin S Hirsch; R T Schooley
Synergistic inhibition of human immunodeficiency virus type 1 (HIV-1) replication in vitro by recombinant soluble CD4 and 3'-azido-3'-deoxythymidine.
The Journal of infectious diseases 1989;159(5):837-44.
1989: Victoria A Johnson; Bruce D Walker; M A Barlow; T J Paradis; Ting-Chao Chou; Martin S Hirsch
Synergistic inhibition of human immunodeficiency virus type 1 and type 2 replication in vitro by castanospermine and 3'-azido-3'-deoxythymidine.
Antimicrobial agents and chemotherapy 1989;33(1):53-7.
1988: Bruce D Walker; Charles Flexner; T J Paradis; Thomas C Fuller; Martin S Hirsch; R T Schooley; Bernard Moss
HIV-1 reverse transcriptase is a target for cytotoxic T lymphocytes in infected individuals.
Science (New York, N.Y.) 1988;240(4848):64-6.
1987: Bruce D Walker; M Kowalski; W C Goh; K Kozarsky; M Krieger; C Rosen; L Rohrschneider; W A Haseltine; Joseph Sodroski
Inhibition of human immunodeficiency virus syncytium formation and virus replication by castanospermine.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(22):8120-4.
1987: Bruce D Walker; S Chakrabarti; Bernard Moss; T J Paradis; T Flynn; A G Durno; R S Blumberg; Jean-Claude Kaplan; Martin S Hirsch; R T Schooley
HIV-specific cytotoxic T lymphocytes in seropositive individuals.
Nature 1987;328(6128):345-8.