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Bruce Walker

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

Research Profile (preview)

Living Beings

HIV-1
HIV

Disorders

Anatomy

Genes & Molecular Sequences

Amino Acid Sequence

Chemicals & Drugs

Concepts & Ideas

Physiology

Virus Replication

Procedures

CD4 Lymphocyte Count

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Publications

TOP 3
Singh Ashika; Page Taryn; Moore Penny L; Allgaier Rachel L; Hiramen Keshni; Coovadia Hoosen M; Walker Bruce D; Morris Lynn; Ndung'u Thumbi
Functional and genetic analysis of coreceptor usage by dualtropic HIV-1 subtype C isolates.
Thobakgale Christina F; Prendergast Andrew; Crawford Hayley; Mkhwanazi Nompumelelo; Ramduth Danni; Reddy Sharon; Molina Claudia; Mncube Zenele; Leslie Alasdair; Prado Julia; Chonco Fundi; Mphatshwe Wendy; Tudor-Williams Gareth; Jeena Prakash; Blanckenberg Natasha; Dong Krista; Kiepiela Photini; Coovadia Hoosen; Ndung'u Thumbi; Walker Bruce D; Goulder Philip J R
Impact of HLA in mother and child on disease progression of pediatric human immunodeficiency virus type 1 infection.
Pereyra Florencia; Palmer Sarah; Miura Toshiyuki; Block Brian L; Wiegand Ann; Rothchild Alissa C; Baker Brett; Rosenberg Rachel; Cutrell Emily; Seaman Michael S; Coffin John M; Walker Bruce D
Persistent low-level viremia in HIV-1 elite controllers and relationship to immunologic parameters.

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All Publications

2009: Singh Ashika; Page Taryn; Moore Penny L; Allgaier Rachel L; Hiramen Keshni; Coovadia Hoosen M; Walker Bruce D; Morris Lynn; Ndung'u Thumbi
Functional and genetic analysis of coreceptor usage by dualtropic HIV-1 subtype C isolates.
Virology 2009;393(1):56-67.
2009: Thobakgale Christina F; Prendergast Andrew; Crawford Hayley; Mkhwanazi Nompumelelo; Ramduth Danni; Reddy Sharon; Molina Claudia; Mncube Zenele; Leslie Alasdair; Prado Julia; Chonco Fundi; Mphatshwe Wendy; Tudor-Williams Gareth; Jeena Prakash; Blanckenberg Natasha; Dong Krista; Kiepiela Photini; Coovadia Hoosen; Ndung'u Thumbi; Walker Bruce D; Goulder Philip J R
Impact of HLA in mother and child on disease progression of pediatric human immunodeficiency virus type 1 infection.
Journal of virology 2009;83(19):10234-44.
2009: Pereyra Florencia; Palmer Sarah; Miura Toshiyuki; Block Brian L; Wiegand Ann; Rothchild Alissa C; Baker Brett; Rosenberg Rachel; Cutrell Emily; Seaman Michael S; Coffin John M; Walker Bruce D
Persistent low-level viremia in HIV-1 elite controllers and relationship to immunologic parameters.
The Journal of infectious diseases 2009;200(6):984-90.
2009: Streeck Hendrik; Jolin Jonathan S; Qi Ying; Yassine-Diab Bader; Johnson Randall C; Kwon Douglas S; Addo Marylyn M; Brumme Chanson; Routy Jean-Pierre; Little Susan; Jessen Heiko K; Kelleher Anthony D; Hecht Frederick M; Sekaly Rafick-Pierre; Rosenberg Eric S; Walker Bruce D; Carrington Mary; Altfeld Marcus
Human immunodeficiency virus type 1-specific CD8+ T-cell responses during primary infection are major determinants of the viral set point and loss of CD4+ T cells.
Journal of virology 2009;83(15):7641-8.
2009: Lazaro Estibaliz; Godfrey Sasha Blue; Stamegna Pamela; Ogbechie Tobi; Kerrigan Christopher; Zhang Mei; Walker Bruce D; Le Gall Sylvie
Differential HIV epitope processing in monocytes and CD4 T cells affects cytotoxic T lymphocyte recognition.
The Journal of infectious diseases 2009;200(2):236-43.
2009: Brainard Diana M; Seung Edward; Frahm Nicole; Cariappa Annaiah; Bailey Charles C; Hart William K; Shin Hae-Sook; Brooks Sarah F; Knight Heather L; Eichbaum Quentin; Yang Yong-Guang; Sykes Megan; Walker Bruce D; Freeman Gordon J; Pillai Shiv; Westmoreland Susan V; Brander Christian; Luster Andrew D; Tager Andrew M
Induction of robust cellular and humoral virus-specific adaptive immune responses in human immunodeficiency virus-infected humanized BLT mice.
Journal of virology 2009;83(14):7305-21.
2009: Brockman Mark A; Kwon Douglas S; Tighe Daniel P; Pavlik David F; Rosato Pamela C; Sela Jennifer; Porichis Filippos; Le Gall Sylvie; Waring Michael T; Moss Kristin; Jessen Heiko; Pereyra Florencia; Kavanagh Daniel G; Walker Bruce D; Kaufmann Daniel E
IL-10 is up-regulated in multiple cell types during viremic HIV infection and reversibly inhibits virus-specific T cells.
Blood 2009;114(2):346-56.
2009: Julg Boris; Reddy Shabashini; van der Stok Mary; Kulkarni Smita; Qi Ying; Bass Sara; Gold Bert; Nalls Michael A; Nelson George W; Walker Bruce D; Carrington Mary; Ndung'u Thumbi
Lack of Duffy antigen receptor for chemokines: no influence on HIV disease progression in an African treatment-naive population.
Cell host & microbe 2009;5(5):413-5; author reply 418-9.
2009: Kaufmann Daniel E; Walker Bruce D
PD-1 and CTLA-4 inhibitory cosignaling pathways in HIV infection and the potential for therapeutic intervention.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(10):5891-7.
2009: Matthews Philippa C; Leslie Alasdair J; Katzourakis Aris; Crawford Hayley; Payne Rebecca; Prendergast Andrew; Power Karen; Kelleher Anthony D; Klenerman Paul; Carlson Jonathan; Heckerman David; Ndung'u Thumbi; Walker Bruce D; Allen Todd M; Pybus Oliver G; Goulder Philip J R
HLA footprints on human immunodeficiency virus type 1 are associated with interclade polymorphisms and intraclade phylogenetic clustering.
Journal of virology 2009;83(9):4605-15.
2009: Crawford Hayley; Lumm Wendy; Leslie Alasdair; Schaefer Malinda; Boeras Debrah; Prado Julia G; Tang Jianming; Farmer Paul; Ndung'u Thumbi; Lakhi Shabir; Gilmour Jill; Goepfert Paul; Walker Bruce D; Kaslow Richard; Mulenga Joseph; Allen Susan; Goulder Philip J R; Hunter Eric
Evolution of HLA-B*5703 HIV-1 escape mutations in HLA-B*5703-positive individuals and their transmission recipients.
The Journal of experimental medicine 2009;206(4):909-21.
2009: Chen Huabiao; Piechocka-Trocha Alicja; Miura Toshiyuki; Brockman Mark A; Julg Boris D; Baker Brett M; Rothchild Alissa C; Block Brian L; Schneidewind Arne; Koibuchi Tomohiko; Pereyra Florencia; Allen Todd M; Walker Bruce D
Differential neutralization of human immunodeficiency virus (HIV) replication in autologous CD4 T cells by HIV-specific cytotoxic T lymphocytes.
Journal of virology 2009;83(7):3138-49.
2009: Scheid Johannes F; Mouquet Hugo; Feldhahn Niklas; Walker Bruce D; Pereyra Florencia; Cutrell Emily; Seaman Michael S; Mascola John R; Wyatt Richard T; Wardemann Hedda; Nussenzweig Michel C
A method for identification of HIV gp140 binding memory B cells in human blood.
Journal of immunological methods 2009;343(2):65-7.
2009: Schneidewind Arne; Brumme Zabrina L; Brumme Chanson J; Power Karen A; Reyor Laura L; O'Sullivan Kristin; Gladden Adrianne; Hempel Ursula; Kuntzen Thomas; Wang Yaoyu E; Oniangue-Ndza Cesar; Jessen Heiko; Markowitz Martin; Rosenberg Eric S; Sékaly Rafick-Pierre; Kelleher Anthony D; Walker Bruce D; Allen Todd M
Transmission and long-term stability of compensated CD8 escape mutations.
Journal of virology 2009;83(8):3993-7.
2009: Rousseau Christine M; Lockhart David W; Listgarten Jennifer; Maley Stephen N; Kadie Carl; Learn Gerald H; Nickle David C; Heckerman David E; Deng Wenjie; Brander Christian; Ndung'u Thumbi; Coovadia Hoosen; Goulder Philip J R; Korber Bette T; Walker Bruce D; Mullins James I
Rare HLA drive additional HIV evolution compared to more frequent alleles.
AIDS research and human retroviruses 2009;25(3):297-303.
2009: Miura Toshiyuki; Brockman Mark A; Schneidewind Arne; Lobritz Michael; Pereyra Florencia; Rathod Almas; Block Brian L; Brumme Zabrina L; Brumme Chanson J; Baker Brett; Rothchild Alissa C; Li Bin; Trocha Alicja; Cutrell Emily; Frahm Nicole; Brander Christian; Toth Ildiko; Arts Eric J; Allen Todd M; Walker Bruce D
HLA-B57/B*5801 human immunodeficiency virus type 1 elite controllers select for rare gag variants associated with reduced viral replication capacity and strong cytotoxic T-lymphocyte [corrected] recognition.
Journal of virology 2009;83(6):2743-55.
2009: Wang Yaoyu E; Li Bin; Carlson Jonathan M; Streeck Hendrik; Gladden Adrianne D; Goodman Robert; Schneidewind Arne; Power Karen A; Toth Ildiko; Frahm Nicole; Alter Galit; Brander Christian; Carrington Mary; Walker Bruce D; Altfeld Marcus; Heckerman David; Allen Todd M
Protective HLA class I alleles that restrict acute-phase CD8+ T-cell responses are associated with viral escape mutations located in highly conserved regions of human immunodeficiency virus type 1.
Journal of virology 2009;83(4):1845-55.
2009: Streeck Hendrik; Jessen Heiko; Kuecherer Claudia; Li Bin; Jessen Arne B; Dupke Stephan; Baumgarten Axel; Stahmer Ingrid; van Lunzen Jan; Altfeld Marcus; Walker Bruce D; Allen Todd M
Epidemiologically linked transmission of HIV-1 illustrates the impact of host genetics on virological outcome.
AIDS (London, England) 2009;23(2):259-62.
2009: Miura Toshiyuki; Brockman Mark A; Brumme Zabrina L; Brumme Chanson J; Pereyra Florencia; Trocha Alicja; Block Brian L; Schneidewind Arne; Allen Todd M; Heckerman David; Walker Bruce D
HLA-associated alterations in replication capacity of chimeric NL4-3 viruses carrying gag-protease from elite controllers of human immunodeficiency virus type 1.
Journal of virology 2009;83(1):140-9.
2009: Ramduth Danni; Day Cheryl L; Thobakgale Christina F; Mkhwanazi Nompumelelo P; de Pierres Chantal; Reddy Sharon; van der Stok Mary; Mncube Zenele; Nair Kriebashne; Moodley Eshia S; Kaufmann Daniel E; Streeck Hendrik; Coovadia Hoosen M; Kiepiela Photini; Goulder Philip J R; Walker Bruce D
Immunodominant HIV-1 Cd4+ T cell epitopes in chronic untreated clade C HIV-1 infection.
PloS one 2009;4(4):e5013.
2008: Huang Sihong; Dunkley-Thompson Jacqueline; Tang Yanhua; Macklin Eric A; Steel-Duncan Julianne; Singh-Minott Indira; Ryland Elizabeth G; Smikle Monica; Walker Bruce D; Christie Celia D C; Feeney Margaret E
Deficiency of HIV-Gag-specific T cells in early childhood correlates with poor viral containment.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(11):8103-11.
2008: Carlson Jonathan M; Brumme Zabrina L; Rousseau Christine M; Brumme Chanson J; Matthews Philippa; Kadie Carl; Mullins James I; Walker Bruce D; Harrigan P Richard; Goulder Philip J R; Heckerman David
Phylogenetic dependency networks: inferring patterns of CTL escape and codon covariation in HIV-1 Gag.
PLoS computational biology 2008;4(11):e1000225.
2008: Brumme Zabrina L; Brumme Chanson J; Carlson Jonathan; Streeck Hendrik; John Mina; Eichbaum Quentin; Block Brian L; Baker Brett; Kadie Carl; Markowitz Martin; Jessen Heiko; Kelleher Anthony D; Rosenberg Eric; Kaldor John; Yuki Yuko; Carrington Mary; Allen Todd M; Mallal Simon; Altfeld Marcus; Heckerman David; Walker Bruce D
Marked epitope- and allele-specific differences in rates of mutation in human immunodeficiency type 1 (HIV-1) Gag, Pol, and Nef cytotoxic T-lymphocyte epitopes in acute/early HIV-1 infection.
Journal of virology 2008;82(18):9216-27.
2008: Matthews Philippa C; Prendergast Andrew; Leslie Alasdair; Crawford Hayley; Payne Rebecca; Rousseau Christine; Rolland Morgane; Honeyborne Isobella; Carlson Jonathan; Kadie Carl; Brander Christian; Bishop Karen; Mlotshwa Nonkululeko; Mullins James I; Coovadia Hoosen; Ndung'u Thumbi; Walker Bruce D; Heckerman David; Goulder Philip J R
Central role of reverting mutations in HLA associations with human immunodeficiency virus set point.
Journal of virology 2008;82(17):8548-59.
2008: Miura Toshiyuki; Brockman Mark A; Brumme Chanson J; Brumme Zabrina L; Carlson Jonathan M; Pereyra Florencia; Trocha Alicja; Addo Marylyn M; Block Brian L; Rothchild Alissa C; Baker Brett M; Flynn Theresa; Schneidewind Arne; Li Bin; Wang Yaoyu E; Heckerman David; Allen Todd M; Walker Bruce D
Genetic characterization of human immunodeficiency virus type 1 in elite controllers: lack of gross genetic defects or common amino acid changes.
Journal of virology 2008;82(17):8422-30.
2008: Haining W Nicholas; Ebert Benjamin L; Subrmanian Aravind; Wherry E John; Eichbaum Quentin; Evans John W; Mak Raymond; Rivoli Stephen; Pretz Jennifer; Angelosanto Jill; Smutko John S; Walker Bruce D; Kaech Susan M; Ahmed Rafi; Nadler Lee M; Golub Todd R
Identification of an evolutionarily conserved transcriptional signature of CD8 memory differentiation that is shared by T and B cells.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(3):1859-68.
2008: Prendergast Andrew; Mphatswe Wendy; Tudor-Williams Gareth; Rakgotho Mpho; Pillay Visva; Thobakgale Christina; McCarthy Noel; Morris Lynn; Walker Bruce D; Goulder Philip
Early virological suppression with three-class antiretroviral therapy in HIV-infected African infants.
AIDS (London, England) 2008;22(11):1333-43.
2008: Rousseau Christine M; Daniels Marcus G; Carlson Jonathan M; Kadie Carl; Crawford Hayley; Prendergast Andrew; Matthews Philippa; Payne Rebecca; Rolland Morgane; Raugi Dana N; Maust Brandon S; Learn Gerald H; Nickle David C; Coovadia Hoosen; Ndung'u Thumbi; Frahm Nicole; Brander Christian; Walker Bruce D; Goulder Philip J R; Bhattacharya Tanmoy; Heckerman David E; Korber Bette T; Mullins James I
HLA class I-driven evolution of human immunodeficiency virus type 1 subtype c proteome: immune escape and viral load.
Journal of virology 2008;82(13):6434-46.
2008: Schneidewind Arne; Brockman Mark A; Sidney John; Wang Yaoyu E; Chen Huabiao; Suscovich Todd J; Li Bin; Adam Rahma I; Allgaier Rachel L; Mothé Bianca R; Kuntzen Thomas; Oniangue-Ndza Cesar; Trocha Alicja; Yu Xu G; Brander Christian; Sette Alessandro; Walker Bruce D; Allen Todd M
Structural and functional constraints limit options for cytotoxic T-lymphocyte escape in the immunodominant HLA-B27-restricted epitope in human immunodeficiency virus type 1 capsid.
Journal of virology 2008;82(11):5594-605.
2008: Streeck Hendrik; Brumme Zabrina L; Anastario Michael; Cohen Kristin W; Jolin Jonathan S; Meier Angela; Brumme Chanson J; Rosenberg Eric S; Alter Galit; Allen Todd M; Walker Bruce D; Altfeld Marcus
Antigen load and viral sequence diversification determine the functional profile of HIV-1-specific CD8+ T cells.
PLoS medicine 2008;5(5):e100.
2008: Day Cheryl L; Mkhwanazi Nompumelelo; Reddy Sharon; Mncube Zenele; van der Stok Mary; Klenerman Paul; Walker Bruce D
Detection of polyfunctional Mycobacterium tuberculosis-specific T cells and association with viral load in HIV-1-infected persons.
The Journal of infectious diseases 2008;197(7):990-9.
2008: Kasprowicz Victoria; Ward Scott M; Turner Alison; Grammatikos Alexandros; Nolan Brian E; Lewis-Ximenez Lia; Sharp Charles; Woodruff Jenny; Fleming Vicki M; Sims Stuart; Walker Bruce D; Sewell Andrew K; Lauer Georg M; Klenerman Paul
Defining the directionality and quality of influenza virus-specific CD8+ T cell cross-reactivity in individuals infected with hepatitis C virus.
The Journal of clinical investigation 2008;118(3):1143-53.
2008: Joseph Aviva; Zheng Jian Hua; Follenzi Antonia; Dilorenzo Teresa; Sango Kaori; Hyman Jaime; Chen Ken; Piechocka-Trocha Alicja; Brander Christian; Hooijberg Erik; Vignali Dario A; Walker Bruce D; Goldstein Harris
Lentiviral vectors encoding human immunodeficiency virus type 1 (HIV-1)-specific T-cell receptor genes efficiently convert peripheral blood CD8 T lymphocytes into cytotoxic T lymphocytes with potent in vitro and in vivo HIV-1-specific inhibitory activity.
Journal of virology 2008;82(6):3078-89.
2008: Kasprowicz Victoria; Schulze Zur Wiesch Julian; Kuntzen Thomas; Nolan Brian E; Longworth Steven; Berical Andrew; Blum Jenna; McMahon Cory; Reyor Laura L; Elias Nahel; Kwok William W; McGovern Barbara G; Freeman Gordon; Chung Raymond T; Klenerman Paul; Lewis-Ximenez Lia; Walker Bruce D; Allen Todd M; Kim Arthur Y; Lauer Georg M
High level of PD-1 expression on hepatitis C virus (HCV)-specific CD8+ and CD4+ T cells during acute HCV infection, irrespective of clinical outcome.
Journal of virology 2008;82(6):3154-60.
2008: Frahm Nicole; Nickle David C; Linde Caitlyn H; Cohen Daniel E; Zuñiga Rosario; Lucchetti Aldo; Roach Timothy; Walker Bruce D; Allen Todd M; Korber Bette T; Mullins James I; Brander Christian
Increased detection of HIV-specific T cell responses by combination of central sequences with comparable immunogenicity.
AIDS (London, England) 2008;22(4):447-56.
2008: Ramduth Danni; Thobakgale Christina F; Mkhwanazi Nompumelelo P; De Pierres Chantal; Reddy Sharon; van der Stok Mary; Mncube Zenele; Mphatswe Wendy; Blanckenberg Natasha; Cengimbo Ayanda; Prendergast Andrew; Tudor-Williams Gareth; Dong Krista; Jeena Prakash; Coovadia Hoosen M; Day Cheryl L; Kiepiela Photini; Goulder Philip J R; Walker Bruce D
Detection of HIV type 1 gag-specific CD4(+) T cell responses in acutely infected infants.
AIDS research and human retroviruses 2008;24(2):265-70.
2008: Pereyra Florencia; Addo Marylyn M; Kaufmann Daniel E; Liu Yang; Miura Toshiyuki; Rathod Almas; Baker Brett; Trocha Alicja; Rosenberg Rachel; Mackey Elizabeth; Ueda Peggy; Lu Zhigang; Cohen Daniel; Wrin Terri; Petropoulos Christos J; Rosenberg Eric S; Walker Bruce D
Genetic and immunologic heterogeneity among persons who control HIV infection in the absence of therapy.
The Journal of infectious diseases 2008;197(4):563-71.
2008: Northfield John W; Kasprowicz Victoria; Lucas Michaela; Kersting Nadine; Bengsch Bertram; Kim Arthur; Phillips Rodney E; Walker Bruce D; Thimme Robert; Lauer Georg; Klenerman Paul
CD161 expression on hepatitis C virus-specific CD8+ T cells suggests a distinct pathway of T cell differentiation.
Hepatology (Baltimore, Md.) 2008;47(2):396-406.
2008: Ngumbela K C; Day C L; Mncube Z; Nair K; Ramduth D; Thobakgale C; Moodley E; Reddy S; de Pierres C; Mkhwanazi N; Bishop K; van der Stok M; Ismail N; Honeyborne I; Crawford H; Kavanagh D G; Rousseau C; Nickle D; Mullins J; Heckerman D; Korber B; Coovadia H; Kiepiela P; Goulder P J R; Walker B D
Targeting of a CD8 T cell env epitope presented by HLA-B*5802 is associated with markers of HIV disease progression and lack of selection pressure.
AIDS research and human retroviruses 2008;24(1):72-82.
2008: Rolland Morgane; Heckerman David; Deng Wenjie; Rousseau Christine M; Coovadia Hoosen; Bishop Karen; Goulder Philip J R; Walker Bruce D; Brander Christian; Mullins James I
Broad and Gag-biased HIV-1 epitope repertoires are associated with lower viral loads.
PloS one 2008;3(1):e1424.
2007: Thobakgale Christina F; Ramduth Dhanwanthie; Reddy Sharon; Mkhwanazi Nompumelelo; de Pierres Chantal; Moodley Eshia; Mphatswe Wendy; Blanckenberg Natasha; Cengimbo Ayanda; Prendergast Andrew; Tudor-Williams Gareth; Dong Krista; Jeena Prakash; Kindra Gupreet; Bobat Raziya; Coovadia Hoosen; Kiepiela Photini; Walker Bruce D; Goulder Philip J R
Human immunodeficiency virus-specific CD8+ T-cell activity is detectable from birth in the majority of in utero-infected infants.
Journal of virology 2007;81(23):12775-84.
2007: Lichterfeld Mathias; Kavanagh Daniel G; Williams Katie L; Moza Beenu; Mui Stanley K; Miura ToshiYuki; Sivamurthy Rohini; Allgaier Rachel; Pereyra Florencia; Trocha Alicja; Feeney Margaret; Gandhi Rajesh T; Rosenberg Eric S; Altfeld Marcus; Allen Todd M; Allen Rachel; Walker Bruce D; Sundberg Eric J; Yu Xu G
A viral CTL escape mutation leading to immunoglobulin-like transcript 4-mediated functional inhibition of myelomonocytic cells.
The Journal of experimental medicine 2007;204(12):2813-24.
2007: Frahm Nicole; Kaufmann Daniel E; Yusim Karina; Muldoon Mark; Kesmir Can; Linde Caitlyn H; Fischer Will; Allen Todd M; Li Bin; McMahon Ben H; Faircloth Kellie L; Hewitt Hannah S; Mackey Elizabeth W; Miura Toshiyuki; Khatri Ashok; Wolinsky Steven; McMichael Andrew; Funkhouser Robert K; Walker Bruce D; Brander Christian; Korber Bette T
Increased sequence diversity coverage improves detection of HIV-specific T cell responses.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(10):6638-50.
2007: Le Gall Sylvie; Stamegna Pamela; Walker Bruce D
Portable flanking sequences modulate CTL epitope processing.
The Journal of clinical investigation 2007;117(11):3563-75.
2007: Kaufmann Daniel E; Kavanagh Daniel G; Pereyra Florencia; Zaunders John J; Mackey Elizabeth W; Miura Toshiyuki; Palmer Sarah; Brockman Mark; Rathod Almas; Piechocka-Trocha Alicja; Baker Brett; Zhu Baogong; Le Gall Sylvie; Waring Michael T; Ahern Ryan; Moss Kristin; Kelleher Anthony D; Coffin John M; Freeman Gordon J; Rosenberg Eric S; Walker Bruce D
Upregulation of CTLA-4 by HIV-specific CD4+ T cells correlates with disease progression and defines a reversible immune dysfunction.
Nature immunology 2007;8(11):1246-54.
2007: Yu Xu G; Lichterfeld Mathias; Williams Katie L; Martinez-Picado Javier; Walker Bruce D
Random T-cell receptor recruitment in human immunodeficiency virus type 1 (HIV-1)-specific CD8+ T cells from genetically identical twins infected with the same HIV-1 strain.
Journal of virology 2007;81(22):12666-9.
2007: Brockman Mark A; Schneidewind Arne; Lahaie Matthew; Schmidt Aaron; Miura Toshiyuki; Desouza Ivna; Ryvkin Faina; Derdeyn Cynthia A; Allen Susan; Hunter Eric; Mulenga Joseph; Goepfert Paul A; Walker Bruce D; Allen Todd M
Escape and compensation from early HLA-B57-mediated cytotoxic T-lymphocyte pressure on human immunodeficiency virus type 1 Gag alter capsid interactions with cyclophilin A.
Journal of virology 2007;81(22):12608-18.
2007: Frahm Nicole; Yusim Karina; Suscovich Todd J; Adams Sharon; Sidney John; Hraber Peter; Hewitt Hannah S; Linde Caitlyn H; Kavanagh Daniel G; Woodberry Tonia; Henry Leah M; Faircloth Kellie; Listgarten Jennifer; Kadie Carl; Jojic Nebojsa; Sango Kaori; Brown Nancy V; Pae Eunice; Zaman M Tauheed; Bihl Florian; Khatri Ashok; John Mina; Mallal Simon; Marincola Francesco M; Walker Bruce D; Sette Alessandro; Heckerman David; Korber Bette T; Brander Christian
Extensive HLA class I allele promiscuity among viral CTL epitopes.
European journal of immunology 2007;37(9):2419-33.
2007: Schulze Zur Wiesch Julian; Lauer Georg M; Timm Joerg; Kuntzen Thomas; Neukamm Martin; Berical Andrew; Jones Andrea M; Nolan Brian E; Longworth Steve A; Kasprowicz Victoria; McMahon Cory; Wurcel Alysse; Lohse Ansgar W; Lewis-Ximenez Lia L; Chung Raymond T; Kim Arthur Y; Allen Todd M; Walker Bruce D
Immunologic evidence for lack of heterologous protection following resolution of HCV in patients with non-genotype 1 infection.
Blood 2007;110(5):1559-69.
2007: Walker Bruce D
Elite control of HIV Infection: implications for vaccines and treatment.
Topics in HIV medicine : a publication of the International AIDS Society, USA 2007;15(4):134-6.
2007: Brainard Diana M; Tager Andrew M; Misdraji Joseph; Frahm Nicole; Lichterfeld Mathias; Draenert Rika; Brander Christian; Walker Bruce D; Luster Andrew D
Decreased CXCR3+ CD8 T cells in advanced human immunodeficiency virus infection suggest that a homing defect contributes to cytotoxic T-lymphocyte dysfunction.
Journal of virology 2007;81(16):8439-50.
2007: Crawford Hayley; Prado Julia G; Leslie Alasdair; Hué Stéphane; Honeyborne Isobella; Reddy Sharon; van der Stok Mary; Mncube Zenele; Brander Christian; Rousseau Christine; Mullins James I; Kaslow Richard; Goepfert Paul; Allen Susan; Hunter Eric; Mulenga Joseph; Kiepiela Photini; Walker Bruce D; Goulder Philip J R
Compensatory mutation partially restores fitness and delays reversion of escape mutation within the immunodominant HLA-B*5703-restricted Gag epitope in chronic human immunodeficiency virus type 1 infection.
Journal of virology 2007;81(15):8346-51.
2007: Brumme Zabrina L; Brumme Chanson J; Heckerman David; Korber Bette T; Daniels Marcus; Carlson Jonathan; Kadie Carl; Bhattacharya Tanmoy; Chui Celia; Szinger James; Mo Theresa; Hogg Robert S; Montaner Julio S G; Frahm Nicole; Brander Christian; Walker Bruce D; Harrigan P Richard
Evidence of differential HLA class I-mediated viral evolution in functional and accessory/regulatory genes of HIV-1.
PLoS pathogens 2007;3(7):e94.
2007: Streeck Hendrik; Lichterfeld Mathias; Alter Galit; Meier Angela; Teigen Nickolas; Yassine-Diab Bader; Sidhu Harlyn K; Little Susan; Kelleher Anthony; Routy Jean-Pierre; Rosenberg Eric S; Sekaly Rafick-Pierre; Walker Bruce D; Altfeld Marcus
Recognition of a defined region within p24 gag by CD8+ T cells during primary human immunodeficiency virus type 1 infection in individuals expressing protective HLA class I alleles.
Journal of virology 2007;81(14):7725-31.
2007: Mphatswe Wendy; Blanckenberg Natasha; Tudor-Williams Gareth; Prendergast Andrew; Thobakgale Christina; Mkhwanazi Nompumelelo; McCarthy Noel; Walker Bruce D; Kiepiela Photini; Goulder Philip
High frequency of rapid immunological progression in African infants infected in the era of perinatal HIV prophylaxis.
AIDS (London, England) 2007;21(10):1253-61.
2007: Frater A J; Brown H; Oxenius A; Günthard H F; Hirschel B; Robinson N; Leslie A J; Payne R; Crawford H; Prendergast A; Brander C; Kiepiela P; Walker B D; Goulder P J R; McLean A; Phillips R E
Effective T-cell responses select human immunodeficiency virus mutants and slow disease progression.
Journal of virology 2007;81(12):6742-51.
2007: Timm J; Neukamm M; Kuntzen T; Kim A Y; Chung R T; Brander C; Lauer G M; Walker B D; Allen T M
Characterization of full-length hepatitis C virus genotype 4 sequences.
Journal of viral hepatitis 2007;14(5):330-7.
2007: Rousseau Christine M; Learn Gerald H; Bhattacharya Tanmoy; Nickle David C; Heckerman David; Chetty Senica; Brander Christian; Goulder Philip J R; Walker Bruce D; Kiepiela Photini; Korber Bette T; Mullins James I
Extensive intrasubtype recombination in South African human immunodeficiency virus type 1 subtype C infections.
Journal of virology 2007;81(9):4492-500.
2007: Streeck Hendrik; Schweighardt Becky; Jessen Heiko; Allgaier Rachel L; Wrin Terri; Stawiski Eric W; Jessen Arne B; Allen Todd M; Walker Bruce D; Altfeld Marcus
Loss of HIV-1-specific T-cell responses associated with very rapid HIV-1 disease progression.
AIDS (London, England) 2007;21(7):889-91.
2007: Lichterfeld Mathias; Yu Xu G; Mui Stanley K; Williams Katie L; Trocha Alicja; Brockman Mark A; Allgaier Rachel L; Waring Michael T; Koibuchi Tomohiko; Johnston Mary N; Cohen Daniel; Allen Todd M; Rosenberg Eric S; Walker Bruce D; Altfeld Marcus
Selective depletion of high-avidity human immunodeficiency virus type 1 (HIV-1)-specific CD8+ T cells after early HIV-1 infection.
Journal of virology 2007;81(8):4199-214.
2007: Honeyborne Isobella; Prendergast Andrew; Pereyra Florencia; Leslie Alasdair; Crawford Hayley; Payne Rebecca; Reddy Shabashini; Bishop Karen; Moodley Eshia; Nair Kriebashnie; van der Stok Mary; McCarthy Noel; Rousseau Christine M; Addo Marylyn; Mullins James I; Brander Christian; Kiepiela Photini; Walker Bruce D; Goulder Philip J R
Control of human immunodeficiency virus type 1 is associated with HLA-B*13 and targeting of multiple gag-specific CD8+ T-cell epitopes.
Journal of virology 2007;81(7):3667-72.
2007: Yu Xu G; Lichterfeld Mathias; Chetty Senica; Williams Katie L; Mui Stanley K; Miura Toshiyuki; Frahm Nicole; Feeney Margaret E; Tang Yanhua; Pereyra Florencia; Labute Montiago X; Pfafferott Katja; Leslie Alisdair; Crawford Hayley; Allgaier Rachel; Hildebrand William; Kaslow Richard; Brander Christian; Allen Todd M; Rosenberg Eric S; Kiepiela Photini; Vajpayee Madhu; Goepfert Paul A; Altfeld Marcus; Goulder Philip J R; Walker Bruce D
Mutually exclusive T-cell receptor induction and differential susceptibility to human immunodeficiency virus type 1 mutational escape associated with a two-amino-acid difference between HLA class I subtypes.
Journal of virology 2007;81(4):1619-31.
2007: Fischer Will; Perkins Simon; Theiler James; Bhattacharya Tanmoy; Yusim Karina; Funkhouser Robert; Kuiken Carla; Haynes Barton; Letvin Norman L; Walker Bruce D; Hahn Beatrice H; Korber Bette T
Polyvalent vaccines for optimal coverage of potential T-cell epitopes in global HIV-1 variants.
Nature medicine 2007;13(1):100-6.
2007: Kiepiela Photini; Ngumbela Kholiswa; Thobakgale Christina; Ramduth Dhanwanthie; Honeyborne Isobella; Moodley Eshia; Reddy Shabashini; de Pierres Chantal; Mncube Zenele; Mkhwanazi Nompumelelo; Bishop Karen; van der Stok Mary; Nair Kriebashnie; Khan Nasreen; Crawford Hayley; Payne Rebecca; Leslie Alasdair; Prado Julia; Prendergast Andrew; Frater John; McCarthy Noel; Brander Christian; Learn Gerald H; Nickle David; Rousseau Christine; Coovadia Hoosen; Mullins James I; Heckerman David; Walker Bruce D; Goulder Philip
CD8+ T-cell responses to different HIV proteins have discordant associations with viral load.
Nature medicine 2007;13(1):46-53.
2007: Day Cheryl L; Kiepiela Photini; Leslie Alasdair J; van der Stok Mary; Nair Kriebashne; Ismail Nasreen; Honeyborne Isobella; Crawford Hayley; Coovadia Hoosen M; Goulder Philip J R; Walker Bruce D; Klenerman Paul
Proliferative capacity of epitope-specific CD8 T-cell responses is inversely related to viral load in chronic human immunodeficiency virus type 1 infection.
Journal of virology 2007;81(1):434-8.
2007: Rolland Morgane; Nickle David C; Deng Wenjie; Frahm Nicole; Brander Christian; Learn Gerald H; Heckerman David; Jojic Nebosja; Jojic Vladimir; Walker Bruce D; Mullins James I
Recognition of HIV-1 peptides by host CTL is related to HIV-1 similarity to human proteins.
PloS one 2007;2(9):e823.
2007: Walker Bruce D
HIV controllers: an untapped source of clues to overcoming HIV infection.
Research initiative, treatment action : RITA 2007;12(2):21-2.
2007: Addo Marylyn M; Draenert Rika; Rathod Almas; Verrill Cori L; Davis Benjamin T; Gandhi Rajesh T; Robbins Gregory K; Basgoz Nesli O; Stone David R; Cohen Daniel E; Johnston Mary N; Flynn Theresa; Wurcel Alysse G; Rosenberg Eric S; Altfeld Marcus; Walker Bruce D
Fully differentiated HIV-1 specific CD8+ T effector cells are more frequently detectable in controlled than in progressive HIV-1 infection.
PloS one 2007;2(3):e321.
2006: Kim Arthur Y; Schulze zur Wiesch Julian; Kuntzen Thomas; Timm Joerg; Kaufmann Daniel E; Duncan Jared E; Jones Andrea M; Wurcel Alysse G; Davis Benjamin T; Gandhi Rajesh T; Robbins Gregory K; Allen Todd M; Chung Raymond T; Lauer Georg M; Walker Bruce D
Impaired hepatitis C virus-specific T cell responses and recurrent hepatitis C virus in HIV coinfection.
PLoS medicine 2006;3(12):e492.
2006: Altfeld Marcus; Kalife Elizabeth T; Qi Ying; Streeck Hendrik; Lichterfeld Mathias; Johnston Mary N; Burgett Nicole; Swartz Martha E; Yang Amy; Alter Galit; Yu Xu G; Meier Angela; Rockstroh Juergen K; Allen Todd M; Jessen Heiko; Rosenberg Eric S; Carrington Mary; Walker Bruce D
HLA Alleles Associated with Delayed Progression to AIDS Contribute Strongly to the Initial CD8(+) T Cell Response against HIV-1.
PLoS medicine 2006;3(10):e403.
2006: Zaunders John J; Ip Susanna; Munier Mee Ling; Kaufmann Daniel E; Suzuki Kazuo; Brereton Choechoe; Sasson Sarah C; Seddiki Nabila; Koelsch Kersten; Landay Alan; Grey Pat; Finlayson Robert; Kaldor John; Rosenberg Eric S; Walker Bruce D; Fazekas de St Groth Barbara; Cooper David A; Kelleher Anthony D
Infection of CD127+ (interleukin-7 receptor+) CD4+ cells and overexpression of CTLA-4 are linked to loss of antigen-specific CD4 T cells during primary human immunodeficiency virus type 1 infection.
Journal of virology 2006;80(20):10162-72.
2006: Leslie Alasdair; Price David A; Mkhize Pamela; Bishop Karen; Rathod Almas; Day Cheryl; Crawford Hayley; Honeyborne Isobella; Asher Tedi E; Luzzi Graz; Edwards Anne; Rousseau Christine M; Mullins James I; Tudor-Williams Gareth; Novelli Vas; Brander Christian; Douek Daniel C; Kiepiela Photini; Walker Bruce D; Goulder Philip J R
Differential selection pressure exerted on HIV by CTL targeting identical epitopes but restricted by distinct HLA alleles from the same HLA supertype.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(7):4699-708.
2006: Streeck Hendrik; Jessen Heiko; Alter Galit; Teigen Nickolas; Waring Mike T; Jessen Arne; Stahmer Ingrid; van Lunzen Jan; Lichterfeld Mathias; Gao Xiaojiang; Allen Todd M; Carrington Mary; Walker Bruce D; Rockstroh Juergen K; Altfeld Marcus
Immunological and virological impact of highly active antiretroviral therapy initiated during acute HIV-1 infection.
The Journal of infectious diseases 2006;194(6):734-9.
2006: Day Cheryl L; Kaufmann Daniel E; Kiepiela Photini; Brown Julia A; Moodley Eshia S; Reddy Sharon; Mackey Elizabeth W; Miller Joseph D; Leslie Alasdair J; DePierres Chantal; Mncube Zenele; Duraiswamy Jaikumar; Zhu Baogong; Eichbaum Quentin; Altfeld Marcus; Wherry E John; Coovadia Hoosen M; Goulder Philip J R; Klenerman Paul; Ahmed Rafi; Freeman Gordon J; Walker Bruce D
PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression.
Nature 2006;443(7109):350-4.
2006: Wherry E John; Day Cheryl L; Draenert Rika; Miller Joseph D; Kiepiela Photini; Woodberry Tonia; Brander Christian; Addo Marylyn; Klenerman Paul; Ahmed Rafi; Walker Bruce D
HIV-specific CD8 T cells express low levels of IL-7Ralpha: implications for HIV-specific T cell memory.
Virology 2006;353(2):366-73.
2006: Rousseau Christine M; Birditt Brian A; McKay Angela R; Stoddard Julia N; Lee Tsan Chun; McLaughlin Sherry; Moore Sarah W; Shindo Nice; Learn Gerald H; Korber Bette T; Brander Christian; Goulder Philip J R; Kiepiela Photini; Walker Bruce D; Mullins James I
Large-scale amplification, cloning and sequencing of near full-length HIV-1 subtype C genomes.
Journal of virological methods 2006;136(1-2):118-25.
2006: Brander Christian; Frahm Nicole; Walker Bruce D
The challenges of host and viral diversity in HIV vaccine design.
Current opinion in immunology 2006;18(4):430-7.
2006: Lichterfeld Mathias; Williams Katie L; Mui Stanley K; Shah Shivani S; Mothe Bianca R; Sette Alessandro; Kim Arthur; Johnston Mary N; Burgett Nicole; Frahm Nicole; Cohen Daniel; Brander Christian; Rosenberg Eric S; Walker Bruce D; Altfeld Marcus; Yu Xu G
T cell receptor cross-recognition of an HIV-1 CD8+ T cell epitope presented by closely related alleles from the HLA-A3 superfamily.
International immunology 2006;18(7):1179-88.
2006: Martinez-Hackert Erik; Anikeeva Nadia; Kalams Spyros A; Walker Bruce D; Hendrickson Wayne A; Sykulev Yuri
Structural basis for degenerate recognition of natural HIV peptide variants by cytotoxic lymphocytes.
The Journal of biological chemistry 2006;281(29):20205-12.
2006: McGovern Barbara H; Wurcel Alysse; Kim Arthur Y; Schulze zur Wiesch Julian; Bica Ioana; Zaman M Tauheed; Timm Joerg; Walker Bruce D; Lauer Georg M
Acute hepatitis C virus infection in incarcerated injection drug users.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2006;42(12):1663-70.
2006: Honeyborne Isobella; Rathod Almas; Buchli Rico; Ramduth Dhanwanthie; Moodley Eshia; Rathnavalu Prinisha; Chetty Senica; Day Cheryl; Brander Christian; Hildebrand William; Walker Bruce D; Kiepiela Photini; Goulder Philip J R
Motif inference reveals optimal CTL epitopes presented by HLA class I alleles highly prevalent in southern Africa.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(8):4699-705.
2006: Bihl Florian; Frahm Nicole; Di Giammarino Loriana; Sidney John; John Mina; Yusim Karina; Woodberry Tonia; Sango Kaori; Hewitt Hannah S; Henry Leah; Linde Caitlyn H; Chisholm John V; Zaman Tauheed M; Pae Eunice; Mallal Simon; Walker Bruce D; Sette Alessandro; Korber Bette T; Heckerman David; Brander Christian
Impact of HLA-B alleles, epitope binding affinity, functional avidity, and viral coinfection on the immunodominance of virus-specific CTL responses.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(7):4094-101.
2006: Martinez-Picado Javier; Prado Julia G; Fry Elizabeth E; Pfafferott Katja; Leslie Alasdair; Chetty Senica; Thobakgale Christina; Honeyborne Isobel; Crawford Hayley; Matthews Philippa; Pillay Tilly; Rousseau Christine; Mullins James I; Brander Christian; Walker Bruce D; Stuart David I; Kiepiela Photini; Goulder Philip
Fitness cost of escape mutations in p24 Gag in association with control of human immunodeficiency virus type 1.
Journal of virology 2006;80(7):3617-23.
2006: Kassutto Sigall; Maghsoudi Kaveh; Johnston Mary N; Robbins Gregory K; Burgett Nicole C; Sax Paul E; Cohen Daniel; Pae Eunice; Davis Ben; Zachary Kimon; Basgoz Nesli; D'agata Erika M C; DeGruttola Victor; Walker Bruce D; Rosenberg Eric S
Longitudinal analysis of clinical markers following antiretroviral therapy initiated during acute or early HIV type 1 infection.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2006;42(7):1024-31.
2006: Draenert Rika; Allen Todd M; Liu Yang; Wrin Terri; Chappey Colombe; Verrill Cori L; Sirera Guillem; Eldridge Robert L; Lahaie Matthew P; Ruiz Lidia; Clotet Bonaventura; Petropoulos Christos J; Walker Bruce D; Martinez-Picado Javier
Constraints on HIV-1 evolution and immunodominance revealed in monozygotic adult twins infected with the same virus.
The Journal of experimental medicine 2006;203(3):529-39.
2006: Zuñiga Rosario; Lucchetti Aldo; Galvan Patricia; Sanchez Shyla; Sanchez Carmen; Hernandez Ana; Sanchez Hugo; Frahm Nicole; Linde Caitlyn H; Hewitt Hannah S; Hildebrand William; Altfeld Marcus; Allen Todd M; Walker Bruce D; Korber Bette T; Leitner Thomas; Sanchez Jorge; Brander Christian
Relative dominance of Gag p24-specific cytotoxic T lymphocytes is associated with human immunodeficiency virus control.
Journal of virology 2006;80(6):3122-5.
2006: Meyer-Olson Dirk; Brady Kristen W; Bartman Melissa T; O'Sullivan Kristin M; Simons Brenna C; Conrad Joseph A; Duncan Coley B; Lorey Shelly; Siddique Atif; Draenert Rika; Addo Marylyn; Altfeld Marcus; Rosenberg Eric; Allen Todd M; Walker Bruce D; Kalams Spyros A
Fluctuations of functionally distinct CD8+ T-cell clonotypes demonstrate flexibility of the HIV-specific TCR repertoire.
Blood 2006;107(6):2373-83.
2006: Kavanagh Daniel G; Kaufmann Daniel E; Sunderji Sherzana; Frahm Nicole; Le Gall Sylvie; Boczkowski David; Rosenberg Eric S; Stone David R; Johnston Mary N; Wagner Bradford S; Zaman Mohammad T; Brander Christian; Gilboa Eli; Walker Bruce D; Bhardwaj Nina
Expansion of HIV-specific CD4+ and CD8+ T cells by dendritic cells transfected with mRNA encoding cytoplasm- or lysosome-targeted Nef.
Blood 2006;107(5):1963-9.
2006: Norris Philip J; Stone Jennifer D; Anikeeva Nadezhda; Heitman John W; Wilson Ingrid C; Hirschkorn Dale F; Clark Margaret J; Moffett Howell F; Cameron Thomas O; Sykulev Yuri; Stern Lawrence J; Walker Bruce D
Antagonism of HIV-specific CD4+ T cells by C-terminal truncation of a minimum epitope.
Molecular immunology 2006;43(9):1349-57.
2006: Frahm Nicole; Kiepiela Photini; Adams Sharon; Linde Caitlyn H; Hewitt Hannah S; Sango Kaori; Feeney Margaret E; Addo Marylyn M; Lichterfeld Mathias; Lahaie Matthew P; Pae Eunice; Wurcel Alysse G; Roach Timothy; St John M Anne; Altfeld Marcus; Marincola Francesco M; Moore Corey; Mallal Simon; Carrington Mary; Heckerman David; Allen Todd M; Mullins James I; Korber Bette T; Goulder Philip J R; Walker Bruce D; Brander Christian
Control of human immunodeficiency virus replication by cytotoxic T lymphocytes targeting subdominant epitopes.
Nature immunology 2006;7(2):173-8.
2006: Brockman Mark A; Tanzi Giancarlo O; Walker Bruce D; Allen Todd M
Use of a novel GFP reporter cell line to examine replication capacity of CXCR4- and CCR5-tropic HIV-1 by flow cytometry.
Journal of virological methods 2006;131(2):134-42.
2005: Allen Todd M; Altfeld Marcus; Geer Shaun C; Kalife Elizabeth T; Moore Corey; O'sullivan Kristin M; Desouza Ivna; Feeney Margaret E; Eldridge Robert L; Maier Erica L; Kaufmann Daniel E; Lahaie Matthew P; Reyor Laura; Tanzi Giancarlo; Johnston Mary N; Brander Christian; Draenert Rika; Rockstroh Jurgen K; Jessen Heiko; Rosenberg Eric S; Mallal Simon A; Walker Bruce D
Selective escape from CD8+ T-cell responses represents a major driving force of human immunodeficiency virus type 1 (HIV-1) sequence diversity and reveals constraints on HIV-1 evolution.
Journal of virology 2005;79(21):13239-49.
2005: Woodberry Tonia; Suscovich Todd J; Henry Leah M; Davis Jennifer K; Frahm Nicole; Walker Bruce D; Scadden David T; Wang Frederick; Brander Christian
Differential targeting and shifts in the immunodominance of Epstein-Barr virus--specific CD8 and CD4 T cell responses during acute and persistent infection.
The Journal of infectious diseases 2005;192(9):1513-24.
2005: Lauer Georg M; Lucas Michaela; Timm Joerg; Ouchi Kei; Kim Arthur Y; Day Cheryl L; Schulze Zur Wiesch Julian; Paranhos-Baccala Glaucia; Sheridan Isabelle; Casson Deborah R; Reiser Markus; Gandhi Rajesh T; Li Bin; Allen Todd M; Chung Raymond T; Klenerman Paul; Walker Bruce D
Full-breadth analysis of CD8+ T-cell responses in acute hepatitis C virus infection and early therapy.
Journal of virology 2005;79(20):12979-88.
2005: Allen Todd M; Yu Xu G; Kalife Elizabeth T; Reyor Laura L; Lichterfeld Mathias; John Mina; Cheng Michael; Allgaier Rachel L; Mui Stanley; Frahm Nicole; Alter Galit; Brown Nancy V; Johnston Mary N; Rosenberg Eric S; Mallal Simon A; Brander Christian; Walker Bruce D; Altfeld Marcus
De novo generation of escape variant-specific CD8+ T-cell responses following cytotoxic T-lymphocyte escape in chronic human immunodeficiency virus type 1 infection.
Journal of virology 2005;79(20):12952-60.
2005: Schulze zur Wiesch Julian; Lauer Georg M; Day Cheryl L; Kim Arthur Y; Ouchi Kei; Duncan Jared E; Wurcel Alysse G; Timm Joerg; Jones Andrea M; Mothe Bianca; Allen Todd M; McGovern Barbara; Lewis-Ximenez Lia; Sidney John; Sette Alessandro; Chung Raymond T; Walker Bruce D
Broad repertoire of the CD4+ Th cell response in spontaneously controlled hepatitis C virus infection includes dominant and highly promiscuous epitopes.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(6):3603-13.
2005: Yu Xu G; Lichterfeld Mathias; Perkins Beth; Kalife Elizabeth; Mui Stanley; Chen Jianping; Cheng Michael; Kang Wenzhen; Alter Galit; Brander Christian; Walker Bruce D; Altfeld Marcus
High degree of inter-clade cross-reactivity of HIV-1-specific T cell responses at the single peptide level.
AIDS (London, England) 2005;19(14):1449-56.
2005: Zaunders John J; Munier Mee Ling; Kaufmann Daniel E; Ip Susanna; Grey Pat; Smith Don; Ramacciotti Tim; Quan Dick; Finlayson Robert; Kaldor John; Rosenberg Eric S; Walker Bruce D; Cooper David A; Kelleher Anthony D
Early proliferation of CCR5(+) CD38(+++) antigen-specific CD4(+) Th1 effector cells during primary HIV-1 infection.
Blood 2005;106(5):1660-7.
2005: Frahm Nicole; Adams Sharon; Kiepiela Photini; Linde Caitlyn H; Hewitt Hannah S; Lichterfeld Mathias; Sango Kaori; Brown Nancy V; Pae Eunice; Wurcel Alysse G; Altfeld Marcus; Feeney Margaret E; Allen Todd M; Roach Timothy; St John M Anne; Daar Eric S; Rosenberg Eric; Korber Bette; Marincola Francesco; Walker Bruce D; Goulder Philip J R; Brander Christian
HLA-B63 presents HLA-B57/B58-restricted cytotoxic T-lymphocyte epitopes and is associated with low human immunodeficiency virus load.
Journal of virology 2005;79(16):10218-25.
2005: Woodberry Tonia; Suscovich Todd J; Henry Leah M; Martin Jeff N; Dollard Sheila; O'Connor Paula G; Davis Jennifer K; Osmond Dennis; Lee Tzong-Hae; Kedes Dean H; Khatri Ashok; Lee Jeannette; Walker Bruce D; Scadden David T; Brander Christian
Impact of Kaposi sarcoma-associated herpesvirus (KSHV) burden and HIV coinfection on the detection of T cell responses to KSHV ORF73 and ORF65 proteins.
The Journal of infectious diseases 2005;192(4):622-9.
2005: Rodriguez William R; Christodoulides Nicolaos; Floriano Pierre N; Graham Susan; Mohanty Sanghamitra; Dixon Meredith; Hsiang Mina; Peter Trevor; Zavahir Shabnam; Thior Ibou; Romanovicz Dwight; Bernard Bruce; Goodey Adrian P; Walker Bruce D; McDevitt John T
A microchip CD4 counting method for HIV monitoring in resource-poor settings.
PLoS medicine 2005;2(7):e182.
2005: Koibuchi Tomohiko; Allen Todd M; Lichterfeld Mathias; Mui Stanley K; O'Sullivan Kristin M; Trocha Alicja; Kalams Spyros A; Johnson R Paul; Walker Bruce D
Limited sequence evolution within persistently targeted CD8 epitopes in chronic human immunodeficiency virus type 1 infection.
Journal of virology 2005;79(13):8171-81.
2005: Feeney Margaret E; Tang Yanhua; Pfafferott Katja; Roosevelt Kathleen A; Draenert Rika; Trocha Alicja; Yu Xu G; Verrill Cori; Allen Todd; Moore Corey; Mallal Simon; Burchett Sandra; McIntosh Kenneth; Pelton Stephen I; St John M Anne; Hazra Rohan; Klenerman Paul; Altfeld Marcus; Walker Bruce D; Goulder Philip J R
HIV-1 viral escape in infancy followed by emergence of a variant-specific CTL response.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(12):7524-30.
2005: Sumida Shawn M; Truitt Diana M; Lemckert Angelique A C; Vogels Ronald; Custers Jerome H H V; Addo Marylyn M; Lockman Shahin; Peter Trevor; Peyerl Fred W; Kishko Michael G; Jackson Shawn S; Gorgone Darci A; Lifton Michelle A; Essex Myron; Walker Bruce D; Goudsmit Jaap; Havenga Menzo J E; Barouch Dan H
Neutralizing antibodies to adenovirus serotype 5 vaccine vectors are directed primarily against the adenovirus hexon protein.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(11):7179-85.
2005: Altfeld Marcus; Allen Todd M; Kalife Elizabeth T; Frahm Nicole; Addo Marylyn M; Mothe Bianca R; Rathod Almas; Reyor Laura L; Harlow Jason; Yu Xu G; Perkins Beth; Robinson Loren K; Sidney John; Alter Galit; Lichterfeld Mathias; Sette Alessandro; Rosenberg Eric S; Goulder Philip J R; Brander Christian; Walker Bruce D
The majority of currently circulating human immunodeficiency virus type 1 clade B viruses fail to prime cytotoxic T-lymphocyte responses against an otherwise immunodominant HLA-A2-restricted epitope: implications for vaccine design.
Journal of virology 2005;79(8):5000-5.
2005: Kim Arthur Y; Lauer Georg M; Ouchi Kei; Addo Marylyn M; Lucas Michaela; Schulze Zur Wiesch Julian; Timm Joerg; Boczanowski Melinda; Duncan Jared E; Wurcel Alysse G; Casson Deborah; Chung Raymond T; Draenert Rika; Klenerman Paul; Walker Bruce D
The magnitude and breadth of hepatitis C virus-specific CD8+ T cells depend on absolute CD4+ T-cell count in individuals coinfected with HIV-1.
Blood 2005;105(3):1170-8.
2004: Timm Joerg; Lauer Georg M; Kavanagh Daniel G; Sheridan Isabelle; Kim Arthur Y; Lucas Michaela; Pillay Thillagavathie; Ouchi Kei; Reyor Laura L; Schulze zur Wiesch Julian; Gandhi Rajesh T; Chung Raymond T; Bhardwaj Nina; Klenerman Paul; Walker Bruce D; Allen Todd M
CD8 epitope escape and reversion in acute HCV infection.
The Journal of experimental medicine 2004;200(12):1593-604.
2004: Kiepiela Photini; Leslie Alasdair J; Honeyborne Isobella; Ramduth Danni; Thobakgale Christina; Chetty Senica; Rathnavalu Prinisha; Moore Corey; Pfafferott Katja J; Hilton Louise; Zimbwa Peter; Moore Sarah; Allen Todd; Brander Christian; Addo Marylyn M; Altfeld Marcus; James Ian; Mallal Simon; Bunce Michael; Barber Linda D; Szinger James; Day Cheryl; Klenerman Paul; Mullins James; Korber Bette; Coovadia Hoosen M; Walker Bruce D; Goulder Philip J R
Dominant influence of HLA-B in mediating the potential co-evolution of HIV and HLA.
Nature 2004;432(7018):769-75.
2004: Lebedeva Tatiana; Anikeeva Nadja; Kalams Spyros A; Walker Bruce D; Gaidarov Ibragim; Keen James H; Sykulev Yuri
Major histocompatibility complex class I-intercellular adhesion molecule-1 association on the surface of target cells: implications for antigen presentation to cytotoxic T lymphocytes.
Immunology 2004;113(4):460-71.
2004: Hess Christoph; Means Terry K; Autissier Patrick; Woodberry Tonia; Altfeld Marcus; Addo Marylyn M; Frahm Nicole; Brander Christian; Walker Bruce D; Luster Andrew D
IL-8 responsiveness defines a subset of CD8 T cells poised to kill.
Blood 2004;104(12):3463-71.
2004: Kaufmann Daniel E; Lichterfeld Mathias; Altfeld Marcus; Addo Marylyn M; Johnston Mary N; Lee Paul K; Wagner Bradford S; Kalife Elizabeth T; Strick Daryld; Rosenberg Eric S; Walker Bruce D
Limited durability of viral control following treated acute HIV infection.
PLoS medicine 2004;1(2):e36.
2004: Lichterfeld Mathias; Kaufmann Daniel E; Yu Xu G; Mui Stanley K; Addo Marylyn M; Johnston Mary N; Cohen Daniel; Robbins Gregory K; Pae Eunice; Alter Galit; Wurcel Alysse; Stone David; Rosenberg Eric S; Walker Bruce D; Altfeld Marcus
Loss of HIV-1-specific CD8+ T cell proliferation after acute HIV-1 infection and restoration by vaccine-induced HIV-1-specific CD4+ T cells.
The Journal of experimental medicine 2004;200(6):701-12.
2004: Lauer Georg M; Barnes Eleanor; Lucas Michaela; Timm Joerg; Ouchi Kei; Kim Arthur Y; Day Cheryl L; Robbins Gregory K; Casson Deborah R; Reiser Markus; Dusheiko Geoffrey; Allen Todd M; Chung Raymond T; Walker Bruce D; Klenerman Paul
High resolution analysis of cellular immune responses in resolved and persistent hepatitis C virus infection.
Gastroenterology 2004;127(3):924-36.
2004: Zavala-Ruiz Zarixia; Strug Iwona; Walker Bruce D; Norris Philip J; Stern Lawrence J
A hairpin turn in a class II MHC-bound peptide orients residues outside the binding groove for T cell recognition.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(36):13279-84.
2004: Feeney M E; Tang Y; Roosevelt K A; Leslie A J; McIntosh K; Karthas N; Walker B D; Goulder P J R
Immune escape precedes breakthrough human immunodeficiency virus type 1 viremia and broadening of the cytotoxic T-lymphocyte response in an HLA-B27-positive long-term-nonprogressing child.
Journal of virology 2004;78(16):8927-30.
2004: SenGupta Devi; Norris Philip J; Suscovich Todd J; Hassan-Zahraee Mina; Moffett Howell F; Trocha Alicja; Draenert Rika; Goulder Philip J R; Binder Robert J; Levey Daniel L; Walker Bruce D; Srivastava Pramod K; Brander Christian
Heat shock protein-mediated cross-presentation of exogenous HIV antigen on HLA class I and class II.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(3):1987-93.
2004: Lichterfeld Mathias; Yu Xu G; Cohen Daniel; Addo Marylyn M; Malenfant Jessica; Perkins Beth; Pae Eunice; Johnston Mary N; Strick Daryld; Allen Todd M; Rosenberg Eric S; Korber Bette; Walker Bruce D; Altfeld Marcus
HIV-1 Nef is preferentially recognized by CD8 T cells in primary HIV-1 infection despite a relatively high degree of genetic diversity.
AIDS (London, England) 2004;18(10):1383-92.
2004: Allen Todd M; Altfeld Marcus; Yu Xu G; O'Sullivan Kristin M; Lichterfeld Mathias; Le Gall Sylvie; John Mina; Mothe Bianca R; Lee Paul K; Kalife Elizabeth T; Cohen Daniel E; Freedberg Kenneth A; Strick Daryld A; Johnston Mary N; Sette Alessandro; Rosenberg Eric S; Mallal Simon A; Goulder Philip J R; Brander Christian; Walker Bruce D
Selection, transmission, and reversion of an antigen-processing cytotoxic T-lymphocyte escape mutation in human immunodeficiency virus type 1 infection.
Journal of virology 2004;78(13):7069-78.
2004: Lichterfeld Mathias; Yu Xu G; Waring Michael T; Mui Stanley K; Johnston Mary N; Cohen Daniel; Addo Marylyn M; Zaunders John; Alter Galit; Pae Eunice; Strick Daryld; Allen Todd M; Rosenberg Eric S; Walker Bruce D; Altfeld Marcus
HIV-1-specific cytotoxicity is preferentially mediated by a subset of CD8(+) T cells producing both interferon-gamma and tumor necrosis factor-alpha.
Blood 2004;104(2):487-94.
2004: Suscovich Todd J; Paulose-Murphy Mini; Harlow Jason D; Chen Yidong; Thomas Seddon Y; Mellott Tiffany J; Walker Bruce D; Scadden David T; Zeichner Steven; Brander Christian
Defective immune function of primary effusion lymphoma cells is associated with distinct KSHV gene expression profiles.
Leukemia & lymphoma 2004;45(6):1223-38.
2004: Yu Xu G; Addo Marylyn M; Perkins Beth A; Wej Feili; Rathod Almas; Geer Shaun C; Parta Mark; Cohen Daniel; Stone David R; Russell Christopher J; Tanzi Giancarlo; Mei Shan; Wurcel Alysse G; Frahm Nicole; Lichterfeld Mathias; Heath Laura; Mullins James I; Marincola Francesco; Goulder Philip J R; Brander Christian; Allen Todd; Cao Yunzhen; Walker Bruce D; Altfeld Marcus
Differences in the expressed HLA class I alleles effect the differential clustering of HIV type 1-specific T cell responses in infected Chinese and caucasians.
AIDS research and human retroviruses 2004;20(5):557-64.
2004: Brainard Diana M; Tharp William G; Granado Elva; Miller Nicholas; Trocha Alicja K; Ren Xiang-Hui; Conrad Brian; Terwilliger Ernest F; Wyatt Richard; Walker Bruce D; Poznansky Mark C
Migration of antigen-specific T cells away from CXCR4-binding human immunodeficiency virus type 1 gp120.
Journal of virology 2004;78(10):5184-93.
2004: Kaufmann Daniel E; Bailey Paul M; Sidney John; Wagner Bradford; Norris Philip J; Johnston Mary N; Cosimi Lisa A; Addo Marylyn M; Lichterfeld Mathias; Altfeld Marcus; Frahm Nicole; Brander Christian; Sette Alessandro; Walker Bruce D; Rosenberg Eric S
Comprehensive analysis of human immunodeficiency virus type 1-specific CD4 responses reveals marked immunodominance of gag and nef and the presence of broadly recognized peptides.
Journal of virology 2004;78(9):4463-77.
2004: Draenert Rika; Le Gall Sylvie; Pfafferott Katja J; Leslie Alasdair J; Chetty Polan; Brander Christian; Holmes Edward C; Chang Shih-Chung; Feeney Margaret E; Addo Marylyn M; Ruiz Lidia; Ramduth Danni; Jeena Prakash; Altfeld Marcus; Thomas Stephanie; Tang Yanhua; Verrill Cori L; Dixon Catherine; Prado Julia G; Kiepiela Photini; Martinez-Picado Javier; Walker Bruce D; Goulder Philip J R
Immune selection for altered antigen processing leads to cytotoxic T lymphocyte escape in chronic HIV-1 infection.
The Journal of experimental medicine 2004;199(7):905-15.
2004: Draenert Rika; Brander Christian; Yu Xu G; Altfeld Marcus; Verrill Cori L; Feeney Margeret E; Walker Bruce D; Goulder Philip J R
Impact of intrapeptide epitope location on CD8 T cell recognition: implications for design of overlapping peptide panels.
AIDS (London, England) 2004;18(6):871-6.
2004: Norris Philip J; Moffett Howell F; Brander Christian; Allen Todd M; O'Sullivan Kristin M; Cosimi Lisa A; Kaufmann Daniel E; Walker Bruce D; Rosenberg Eric S
Fine specificity and cross-clade reactivity of HIV type 1 Gag-specific CD4+ T cells.
AIDS research and human retroviruses 2004;20(3):315-25.
2004: Hess Christoph; Altfeld Marcus; Thomas Seddon Y; Addo Marylyn M; Rosenberg Eric S; Allen Todd M; Draenert Rika; Eldrige Robert L; van Lunzen Jan; Stellbrink Hans-J; Walker Bruce D; Luster Andrew D
HIV-1 specific CD8+ T cells with an effector phenotype and control of viral replication.
Lancet 2004;363(9412):863-6.
2004: Frahm Nicole; Korber B T; Adams C M; Szinger J J; Draenert R; Addo M M; Feeney M E; Yusim K; Sango K; Brown N V; SenGupta D; Piechocka-Trocha A; Simonis T; Marincola F M; Wurcel A G; Stone D R; Russell C J; Adolf P; Cohen D; Roach T; StJohn A; Khatri A; Davis K; Mullins J; Goulder P J R; Walker B D; Brander C
Consistent cytotoxic-T-lymphocyte targeting of immunodominant regions in human immunodeficiency virus across multiple ethnicities.
Journal of virology 2004;78(5):2187-200.
2004: Leslie A J; Pfafferott K J; Chetty P; Draenert R; Addo M M; Feeney M; Tang Y; Holmes E C; Allen T; Prado J G; Altfeld M; Brander C; Dixon C; Ramduth D; Jeena P; Thomas S A; St John A; Roach T A; Kupfer B; Luzzi G; Edwards A; Taylor G; Lyall H; Tudor-Williams G; Novelli V; Martinez-Picado J; Kiepiela P; Walker B D; Goulder P J R
HIV evolution: CTL escape mutation and reversion after transmission.
Nature medicine 2004;10(3):282-9.
2004: Lucas Michaela; Vargas-Cuero Ana L; Lauer Georg M; Barnes Eleanor; Willberg Christian B; Semmo Nasser; Walker Bruce D; Phillips Rodney; Klenerman Paul
Pervasive influence of hepatitis C virus on the phenotype of antiviral CD8+ T cells.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(3):1744-53.
2004: Draenert R; Verrill C L; Tang Y; Allen T M; Wurcel A G; Boczanowski M; Lechner A; Kim A Y; Suscovich T; Brown N V; Addo M M; Walker B D
Persistent recognition of autologous virus by high-avidity CD8 T cells in chronic, progressive human immunodeficiency virus type 1 infection.
Journal of virology 2004;78(2):630-41.
2003: Altfeld Marcus; Addo Marylyn M; Rosenberg Eric S; Hecht Frederick M; Lee Paul K; Vogel Martin; Yu Xu G; Draenert Rika; Johnston Mary N; Strick Daryld; Allen Todd M; Feeney Margaret E; Kahn James O; Sekaly Rafick P; Levy Jay A; Rockstroh Jürgen K; Goulder Philip J; Walker Bruce D
Influence of HLA-B57 on clinical presentation and viral control during acute HIV-1 infection.
AIDS (London, England) 2003;17(18):2581-91.
2003: Day Cheryl L; Walker Bruce D
Progress in defining CD4 helper cell responses in chronic viral infections.
The Journal of experimental medicine 2003;198(12):1773-7.
2003: Feeney Margaret E; Draenert Rika; Roosevelt Kathleen A; Pelton Stephen I; McIntosh Kenneth; Burchett Sandra K; Mao Charlotte; Walker Bruce D; Goulder Philip J R
Reconstitution of virus-specific CD4 proliferative responses in pediatric HIV-1 infection.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(12):6968-75.
2003: Brander Christian; Walker Bruce D
Gradual adaptation of HIV to human host populations: good or bad news?
Nature medicine 2003;9(11):1359-62.
2003: Delgado Julio C; Leung Jessica Y; Baena Andres; Clavijo Olga P; Vittinghoff Eric; Buchbinder Susan; Wolinsky Steven; Addo Marilynn; Walker Bruce D; Yunis Edmond J; Goldfeld Anne E
The -1030/-862-linked TNF promoter single-nucleotide polymorphisms are associated with the inability to control HIV-1 viremia.
Immunogenetics 2003;55(7):497-501.
2003: Yang Otto O; Sarkis Phuong T Nguyen; Trocha Alicja; Kalams Spyros A; Johnson R Paul; Walker Bruce D
Impacts of avidity and specificity on the antiviral efficiency of HIV-1-specific CTL.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(7):3718-24.
2003: Day Cheryl L; Seth Nilufer P; Lucas Michaela; Appel Heiner; Gauthier Laurent; Lauer Georg M; Robbins Gregory K; Szczepiorkowski Zbigniew M; Casson Deborah R; Chung Raymond T; Bell Shannon; Harcourt Gillian; Walker Bruce D; Klenerman Paul; Wucherpfennig Kai W
Ex vivo analysis of human memory CD4 T cells specific for hepatitis C virus using MHC class II tetramers.
The Journal of clinical investigation 2003;112(6):831-42.
2003: Feeney M E; Roosevelt K A; Tang Y; Pfafferott K J; McIntosh K; Burchett S K; Mao C; Walker B D; Goulder P J R
Comprehensive screening reveals strong and broadly directed human immunodeficiency virus type 1-specific CD8 responses in perinatally infected children.
Journal of virology 2003;77(13):7492-501.
2003: Altfeld Marcus; Addo Marylyn M; Shankarappa Raj; Lee Paul K; Allen Todd M; Yu Xu G; Rathod Almas; Harlow Jason; O'Sullivan Kristin; Johnston Mary N; Goulder Philip J R; Mullins James I; Rosenberg Eric S; Brander Christian; Korber Bette; Walker Bruce D
Enhanced detection of human immunodeficiency virus type 1-specific T-cell responses to highly variable regions by using peptides based on autologous virus sequences.
Journal of virology 2003;77(13):7330-40.
2003: Somsouk Ma; Lauer Georg M; Casson Deborah; Terella Adam; Day Cheryl L; Walker Bruce D; Chung Raymond T
Spontaneous resolution of chronic hepatitis C virus disease after withdrawal of immunosuppression.
Gastroenterology 2003;124(7):1946-9.
2003: Robbins Gregory K; Addo Marylyn M; Troung Hien; Rathod Almas; Habeeb Kathy; Davis Benjamin; Heller Howard; Basgoz Nesli; Walker Bruce D; Rosenberg Eric S
Augmentation of HIV-1-specific T helper cell responses in chronic HIV-1 infection by therapeutic immunization.
AIDS (London, England) 2003;17(8):1121-6.
2003: Yang Otto O; Sarkis Phuong Thi Nguyen; Ali Ayub; Harlow Jason D; Brander Christian; Kalams Spyros A; Walker Bruce D
Determinant of HIV-1 mutational escape from cytotoxic T lymphocytes.
The Journal of experimental medicine 2003;197(10):1365-75.
2003: Tremblay Cecile L; Hicks Jennifer L; Sutton Lorraine; Giguel Francoise; Flynn Theresa; Johnston Mary; Sax Paul E; Walker Bruce D; Hirsch Martin S; Rosenberg Eric S; D'Aquila Richard T
Antiretroviral resistance associated with supervised treatment interruptions in treated acute HIV infection.
AIDS (London, England) 2003;17(7):1086-9.
2003: Draenert Rika; Altfeld Marcus; Brander Christian; Basgoz Nesli; Corcoran Colleen; Wurcel Alysse G; Stone David R; Kalams Spyros A; Trocha Alicja; Addo Marylyn M; Goulder Philip J R; Walker Bruce D
Comparison of overlapping peptide sets for detection of antiviral CD8 and CD4 T cell responses.
Journal of immunological methods 2003;275(1-2):19-29.
2003: Montefiori David C; Altfeld Marcus; Lee Paul K; Bilska Miroslawa; Zhou Jintao; Johnston Mary N; Gao Feng; Walker Bruce D; Rosenberg Eric S
Viremia control despite escape from a rapid and potent autologous neutralizing antibody response after therapy cessation in an HIV-1-infected individual.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(7):3906-14.
2003: Severino Michael E; Sarkis Phuong Thi Nguyen; Walker Bruce D; Yang Otto O
Chimeric immune receptor T cells bypass class I requirements and recognize multiple cell types relevant in HIV-1 infection.
Virology 2003;306(2):371-5.
2003: Bobbitt Kevin R; Addo Marylyn M; Altfeld Marcus; Filzen Tracey; Onafuwa Adewunmi A; Walker Bruce D; Collins Kathleen L
Rev activity determines sensitivity of HIV-1-infected primary T cells to CTL killing.
Immunity 2003;18(2):289-99.
2003: Addo M M; Yu X G; Rathod A; Cohen D; Eldridge R L; Strick D; Johnston M N; Corcoran C; Wurcel A G; Fitzpatrick C A; Feeney M E; Rodriguez W R; Basgoz N; Draenert R; Stone David R; Brander C; Goulder P J R; Rosenberg E S; Altfeld M; Walker B D
Comprehensive epitope analysis of human immunodeficiency virus type 1 (HIV-1)-specific T-cell responses directed against the entire expressed HIV-1 genome demonstrate broadly directed responses, but no correlation to viral load.
Journal of virology 2003;77(3):2081-92.
2003: Geiben-Lynn Ralf; Kursar Mischo; Brown Nancy V; Addo Marylyn M; Shau Hungyi; Lieberman Judy; Luster Andrew D; Walker Bruce D
HIV-1 antiviral activity of recombinant natural killer cell enhancing factors, NKEF-A and NKEF-B, members of the peroxiredoxin family.
The Journal of biological chemistry 2003;278(3):1569-74.
2002: Day Cheryl L; Lauer Georg M; Robbins Gregory K; McGovern Barbara; Wurcel Alysse G; Gandhi Rajesh T; Chung Raymond T; Walker Bruce D
Broad specificity of virus-specific CD4+ T-helper-cell responses in resolved hepatitis C virus infection.
Journal of virology 2002;76(24):12584-95.
2002: Altfeld Marcus; Allen Todd M; Yu Xu G; Johnston Mary N; Agrawal Deepak; Korber Bette T; Montefiori David C; O'Connor David H; Davis Ben T; Lee Paul K; Maier Erica L; Harlow Jason; Goulder Philip J R; Brander Christian; Rosenberg Eric S; Walker Bruce D
HIV-1 superinfection despite broad CD8+ T-cell responses containing replication of the primary virus.
Nature 2002;420(6914):434-9.
2002: Geiben-Lynn Ralf; Brown Nancy; Walker Bruce D; Luster Andrew D
Purification of a modified form of bovine antithrombin III as an HIV-1 CD8+ T-cell antiviral factor.
The Journal of biological chemistry 2002;277(44):42352-7.
2002: Allen Todd M; Kelleher Anthony D; Zaunders John; Walker Bruce D
STI and beyond: the prospects of boosting anti-HIV immune responses.
Trends in immunology 2002;23(9):456-60.
2002: Yu Xu G; Addo Marylyn M; Rosenberg Eric S; Rodriguez William R; Lee Paul K; Fitzpatrick Cecily A; Johnston Mary N; Strick Daryld; Goulder Philip J R; Walker Bruce D; Altfeld Marcus
Consistent patterns in the development and immunodominance of human immunodeficiency virus type 1 (HIV-1)-specific CD8+ T-cell responses following acute HIV-1 infection.
Journal of virology 2002;76(17):8690-701.
2002: Gandhi Rajesh T; Walker Bruce D
Promises and pitfalls in the reconstitution of immunity in patients who have HIV-1 infection.
Current opinion in immunology 2002;14(4):487-94.
2002: Brander Christian; Raje Noopur; O'Connor Paula G; Davies Faith; Davis Jennifer; Chauhan Darminder; Hideshima Teru; Martin Jeff; Osmond Dennis; Kedes Dean H; Walker Bruce D; Scadden David T; Anderson Kenneth C
Absence of biologically important Kaposi sarcoma-associated herpesvirus gene products and virus-specific cellular immune responses in multiple myeloma.
Blood 2002;100(2):698-700.
2002: Lauer Georg M; Ouchi Kei; Chung Raymond T; Nguyen Tam N; Day Cheryl L; Purkis Deborah R; Reiser Markus; Kim Arthur Y; Lucas Michaela; Klenerman Paul; Walker Bruce D
Comprehensive analysis of CD8(+)-T-cell responses against hepatitis C virus reveals multiple unpredicted specificities.
Journal of virology 2002;76(12):6104-13.
2002: Addo Marylyn M; Altfeld Marcus; Rathod Almas; Yu Michelle; Yu Xu G; Goulder Philip J R; Rosenberg Eric S; Walker Bruce D
HIV-1 Vpu represents a minor target for cytotoxic T lymphocytes in HIV-1-infection.
AIDS (London, England) 2002;16(7):1071-3.
2002: Yang Otto O; Garcia-Zepeda Eduardo A; Walker Bruce D; Luster Andrew D
Monocyte chemoattractant protein-2 (CC chemokine ligand 8) inhibits replication of human immunodeficiency virus type 1 via CC chemokine receptor 5.
The Journal of infectious diseases 2002;185(8):1174-8.
2002: Altfeld Marcus; van Lunzen Jan; Frahm Nicole; Yu Xu G; Schneider Claus; Eldridge Robert L; Feeney Margaret E; Meyer-Olson Dirk; Stellbrink Hans-Juergen; Walker Bruce D
Expansion of pre-existing, lymph node-localized CD8+ T cells during supervised treatment interruptions in chronic HIV-1 infection.
The Journal of clinical investigation 2002;109(6):837-43.
2002: Lauer Georg M; Nguyen Tam N; Day Cheryl L; Robbins Gregory K; Flynn Theresa; McGowan Katherine; Rosenberg Eric S; Lucas Michaela; Klenerman Paul; Chung Raymond T; Walker Bruce D
Human immunodeficiency virus type 1-hepatitis C virus coinfection: intraindividual comparison of cellular immune responses against two persistent viruses.
Journal of virology 2002;76(6):2817-26.
2002: Yu Xu G; Shang Hong; Addo Marylyn M; Eldridge Robert L; Phillips Mary N; Feeney Margaret E; Strick Daryld; Brander Christian; Goulder Philip J R; Rosenberg Eric S; Walker Bruce D; Altfeld Marcus;
Important contribution of p15 Gag-specific responses to the total Gag-specific CTL responses.
AIDS (London, England) 2002;16(3):321-8.
2002: Yang Otto O; Nguyen Phuong Thi; Kalams Spyros A; Dorfman Tanya; Göttlinger Heinrich G; Stewart Sheila; Chen Irvin S Y; Threlkeld Steven; Walker Bruce D
Nef-mediated resistance of human immunodeficiency virus type 1 to antiviral cytotoxic T lymphocytes.
Journal of virology 2002;76(4):1626-31.
2002: Gandhi Rajesh T; Walker Bruce D
Immunologic control of HIV-1.
Annual review of medicine 2002;53():149-72.
2001: Goulder P J; Pasquier C; Holmes E C; Liang B; Tang Y; Izopet J; Saune K; Rosenberg E S; Burchett S K; McIntosh K; Barnardo M; Bunce M; Walker B D; Brander C; Phillips R E
Mother-to-child transmission of HIV infection and CTL escape through HLA-A2-SLYNTVATL epitope sequence variation.
Immunology letters 2001;79(1-2):109-16.
2001: Montefiori D C; Hill T S; Vo H T; Walker B D; Rosenberg E S
Neutralizing antibodies associated with viremia control in a subset of individuals after treatment of acute human immunodeficiency virus type 1 infection.
Journal of virology 2001;75(21):10200-7.
2001: Norris P J; Sumaroka M; Brander C; Moffett H F; Boswell S L; Nguyen T; Sykulev Y; Walker B D; Rosenberg E S
Multiple effector functions mediated by human immunodeficiency virus-specific CD4(+) T-cell clones.
Journal of virology 2001;75(20):9771-9.
2001: Altfeld M; Addo M M; Eldridge R L; Yu X G; Thomas S; Khatri A; Strick D; Phillips M N; Cohen G B; Islam S A; Kalams S A; Brander C; Goulder P J; Rosenberg E S; Walker B D;
Vpr is preferentially targeted by CTL during HIV-1 infection.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(5):2743-52.
2001: Geiben-Lynn R; Kursar M; Brown N V; Kerr E L; Luster A D; Walker B D
Noncytolytic inhibition of X4 virus by bulk CD8(+) cells from human immunodeficiency virus type 1 (HIV-1)-infected persons and HIV-1-specific cytotoxic T lymphocytes is not mediated by beta-chemokines.
Journal of virology 2001;75(17):8306-16.
2001: Altfeld M; Walker B D
Less is more? STI in acute and chronic HIV-1 infection.
Nature medicine 2001;7(8):881-4.
2001: Walensky R P; Rosenberg E S; Ferraro M J; Losina E; Walker B D; Freedberg K A
Investigation of primary human immunodeficiency virus infection in patients who test positive for heterophile antibody.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2001;33(4):570-2.
2001: Goulder P J; Brander C; Tang Y; Tremblay C; Colbert R A; Addo M M; Rosenberg E S; Nguyen T; Allen R; Trocha A; Altfeld M; He S; Bunce M; Funkhouser R; Pelton S I; Burchett S K; McIntosh K; Korber B T; Walker B D
Evolution and transmission of stable CTL escape mutations in HIV infection.
Nature 2001;412(6844):334-8.
2001: Brander C; O'Connor P; Suscovich T; Jones N G; Lee Y; Kedes D; Ganem D; Martin J; Osmond D; Southwood S; Sette A; Walker B D; Scadden D T
Definition of an optimal cytotoxic T lymphocyte epitope in the latently expressed Kaposi's sarcoma-associated herpesvirus kaposin protein.
The Journal of infectious diseases 2001;184(2):119-26.
2001: Day C L; Shea A K; Altfeld M A; Olson D P; Buchbinder S P; Hecht F M; Rosenberg E S; Walker B D; Kalams S A
Relative dominance of epitope-specific cytotoxic T-lymphocyte responses in human immunodeficiency virus type 1-infected persons with shared HLA alleles.
Journal of virology 2001;75(14):6279-91.
2001: Walker B D; Korber B T
Immune control of HIV: the obstacles of HLA and viral diversity.
Nature immunology 2001;2(6):473-5.
2001: Brander C; Matter-Reissmann U B; Jones N G; Walker B D; Sachs D H; Seebach J D
Inhibition of human NK cell-mediated cytotoxicity by exposure to ammonium chloride.
Journal of immunological methods 2001;252(1-2):1-14.
2001: Flores-Villanueva P O; Yunis E J; Delgado J C; Vittinghoff E; Buchbinder S; Leung J Y; Uglialoro A M; Clavijo O P; Rosenberg E S; Kalams S A; Braun J D; Boswell S L; Walker B D; Goldfeld A E
Control of HIV-1 viremia and protection from AIDS are associated with HLA-Bw4 homozygosity.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(9):5140-5.
2001: Addo M M; Altfeld M; Rosenberg E S; Eldridge R L; Philips M N; Habeeb K; Khatri A; Brander C; Robbins G K; Mazzara G P; Goulder P J; Walker B D;
The HIV-1 regulatory proteins Tat and Rev are frequently targeted by cytotoxic T lymphocytes derived from HIV-1-infected individuals.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(4):1781-6.
2001: Goulder P J; Addo M M; Altfeld M A; Rosenberg E S; Tang Y; Govender U; Mngqundaniso N; Annamalai K; Vogel T U; Hammond M; Bunce M; Coovadia H M; Walker B D
Rapid definition of five novel HLA-A*3002-restricted human immunodeficiency virus-specific cytotoxic T-lymphocyte epitopes by elispot and intracellular cytokine staining assays.
Journal of virology 2001;75(3):1339-47.
2001: Altfeld M A; Livingston B; Reshamwala N; Nguyen P T; Addo M M; Shea A; Newman M; Fikes J; Sidney J; Wentworth P; Chesnut R; Eldridge R L; Rosenberg E S; Robbins G K; Brander C; Sax P E; Boswell S; Flynn T; Buchbinder S; Goulder P J; Walker B D; Sette A; Kalams S A
Identification of novel HLA-A2-restricted human immunodeficiency virus type 1-specific cytotoxic T-lymphocyte epitopes predicted by the HLA-A2 supertype peptide-binding motif.
Journal of virology 2001;75(3):1301-11.
2001: Wong D K; Dudley D D; Dohrenwend P B; Lauer G M; Chung R T; Thomas D L; Walker B D
Detection of diverse hepatitis C virus (HCV)-specific cytotoxic T lymphocytes in peripheral blood of infected persons by screening for responses to all translated proteins of HCV.
Journal of virology 2001;75(3):1229-35.
2001: Goulder P J; Altfeld M A; Rosenberg E S; Nguyen T; Tang Y; Eldridge R L; Addo M M; He S; Mukherjee J S; Phillips M N; Bunce M; Kalams S A; Sekaly R P; Walker B D; Brander C
Substantial differences in specificity of HIV-specific cytotoxic T cells in acute and chronic HIV infection.
The Journal of experimental medicine 2001;193(2):181-94.
2001: Altfeld M; Rosenberg E S; Shankarappa R; Mukherjee J S; Hecht F M; Eldridge R L; Addo M M; Poon S H; Phillips M N; Robbins G K; Sax P E; Boswell S; Kahn J O; Brander C; Goulder P J; Levy J A; Mullins J I; Walker B D
Cellular immune responses and viral diversity in individuals treated during acute and early HIV-1 infection.
The Journal of experimental medicine 2001;193(2):169-80.
2000: Goulder P J; Tang Y; Brander C; Betts M R; Altfeld M; Annamalai K; Trocha A; He S; Rosenberg E S; Ogg G; O'Callaghan C A; Kalams S A; McKinney R E; Mayer K; Koup R A; Pelton S I; Burchett S K; McIntosh K; Walker B D
Functionally inert HIV-specific cytotoxic T lymphocytes do not play a major role in chronically infected adults and children.
The Journal of experimental medicine 2000;192(12):1819-32.
2000: Tremblay C L; Giguel F; Merrill D P; Wong J T; Rosenberg E; Kalams S; Walker B D; D'Aquila R T; Hirsch M S
Marked differences in quantity of infectious human immunodeficiency virus type 1 detected in persons with controlled plasma viremia by a simple enhanced culture method.
Journal of clinical microbiology 2000;38(11):4246-8.
2000: Cao H; Mani I; Vincent R; Mugerwa R; Mugyenyi P; Kanki P; Ellner J; Walker B D
Cellular immunity to human immunodeficiency virus type 1 (HIV-1) clades: relevance to HIV-1 vaccine trials in Uganda.
The Journal of infectious diseases 2000;182(5):1350-6.
2000: Rosenberg E S; Altfeld M; Poon S H; Phillips M N; Wilkes B M; Eldridge R L; Robbins G K; D'Aquila R T; Goulder P J; Walker B D
Immune control of HIV-1 after early treatment of acute infection.
Nature 2000;407(6803):523-6.
2000: Martinez-Picado J; DePasquale M P; Kartsonis N; Hanna G J; Wong J; Finzi D; Rosenberg E; Gunthard H F; Sutton L; Savara A; Petropoulos C J; Hellmann N; Walker B D; Richman D D; Siliciano R; D'Aquila R T
Antiretroviral resistance during successful therapy of HIV type 1 infection.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(20):10948-53.
2000: Altfeld M A; Trocha A; Eldridge R L; Rosenberg E S; Phillips M N; Addo M M; Sekaly R P; Kalams S A; Burchett S A; McIntosh K; Walker B D; Goulder P J
Identification of dominant optimal HLA-B60- and HLA-B61-restricted cytotoxic T-lymphocyte (CTL) epitopes: rapid characterization of CTL responses by enzyme-linked immunospot assay.
Journal of virology 2000;74(18):8541-9.
2000: Brander C; Suscovich T; Lee Y; Nguyen P T; O'Connor P; Seebach J; Jones N G; van Gorder M; Walker B D; Scadden D T
Impaired CTL recognition of cells latently infected with Kaposi's sarcoma-associated herpes virus.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(4):2077-83.
2000: Goulder P J; Lechner F; Klenerman P; McIntosh K; Walker B D
Characterization of a novel respiratory syncytial virus-specific human cytotoxic T-lymphocyte epitope.
Journal of virology 2000;74(16):7694-7.
2000: Severino M E; Sipsas N V; Nguyen P T; Kalams S A; Walker B D; Johnson R P; Yang O O
Inhibition of human immunodeficiency virus type 1 replication in primary CD4(+) T lymphocytes, monocytes, and dendritic cells by cytotoxic T lymphocytes.
Journal of virology 2000;74(14):6695-9.
2000: Goulder P J; Brander C; Annamalai K; Mngqundaniso N; Govender U; Tang Y; He S; Hartman K E; O'Callaghan C A; Ogg G S; Altfeld M A; Rosenberg E S; Cao H; Kalams S A; Hammond M; Bunce M; Pelton S I; Burchett S A; McIntosh K; Coovadia H M; Walker B D
Differential narrow focusing of immunodominant human immunodeficiency virus gag-specific cytotoxic T-lymphocyte responses in infected African and caucasoid adults and children.
Journal of virology 2000;74(12):5679-90.
2000: Goulder P J; Tang Y; Pelton S I; Walker B D
HLA-B57-restricted cytotoxic T-lymphocyte activity in a single infected subject toward two optimal epitopes, one of which is entirely contained within the other.
Journal of virology 2000;74(11):5291-9.
2000: Lechner F; Wong D K; Dunbar P R; Chapman R; Chung R T; Dohrenwend P; Robbins G; Phillips R; Klenerman P; Walker B D
Analysis of successful immune responses in persons infected with hepatitis C virus.
The Journal of experimental medicine 2000;191(9):1499-512.
2000: Walker B D
Can immune responses to human immunodeficiency virus be preserved, enhanced, or restored?
AIDS clinical review 2000;():101-14.
1999: Brander C; Yang O O; Jones N G; Lee Y; Goulder P; Johnson R P; Trocha A; Colbert D; Hay C; Buchbinder S; Bergmann C C; Zweerink H J; Wolinsky S; Blattner W A; Kalams S A; Walker B D
Efficient processing of the immunodominant, HLA-A*0201-restricted human immunodeficiency virus type 1 cytotoxic T-lymphocyte epitope despite multiple variations in the epitope flanking sequences.
Journal of virology 1999;73(12):10191-8.
1999: Brander C; Walker B D
T lymphocyte responses in HIV-1 infection: implications for vaccine development.
Current opinion in immunology 1999;11(4):451-9.
1999: Kalams S A; Goulder P J; Shea A K; Jones N G; Trocha A K; Ogg G S; Walker B D
Levels of human immunodeficiency virus type 1-specific cytotoxic T-lymphocyte effector and memory responses decline after suppression of viremia with highly active antiretroviral therapy.
Journal of virology 1999;73(8):6721-8.
1999: Kalams S A; Buchbinder S P; Rosenberg E S; Billingsley J M; Colbert D S; Jones N G; Shea A K; Trocha A K; Walker B D
Association between virus-specific cytotoxic T-lymphocyte and helper responses in human immunodeficiency virus type 1 infection.
Journal of virology 1999;73(8):6715-20.
1999: Hay C M; Ruhl D J; Basgoz N O; Wilson C C; Billingsley J M; DePasquale M P; D'Aquila R T; Wolinsky S M; Crawford J M; Montefiori D C; Walker B D
Lack of viral escape and defective in vivo activation of human immunodeficiency virus type 1-specific cytotoxic T lymphocytes in rapidly progressive infection.
Journal of virology 1999;73(7):5509-19.
1999: Yang O O; Swanberg S L; Lu Z; Dziejman M; McCoy J; Luster A D; Walker B D; Herrmann S H
Enhanced inhibition of human immunodeficiency virus type 1 by Met-stromal-derived factor 1beta correlates with down-modulation of CXCR4.
Journal of virology 1999;73(6):4582-9.
1999: Wilson C C; Brown R C; Korber B T; Wilkes B M; Ruhl D J; Sakamoto D; Kunstman K; Luzuriaga K; Hanson I C; Widmayer S M; Wiznia A; Clapp S; Ammann A J; Koup R A; Wolinsky S M; Walker B D
Frequent detection of escape from cytotoxic T-lymphocyte recognition in perinatal human immunodeficiency virus (HIV) type 1 transmission: the ariel project for the prevention of transmission of HIV from mother to infant.
Journal of virology 1999;73(5):3975-85.
1999: Brander C; Goulder P J; Luzuriaga K; Yang O O; Hartman K E; Jones N G; Walker B D; Kalams S A
Persistent HIV-1-specific CTL clonal expansion despite high viral burden post in utero HIV-1 infection.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(8):4796-800.
1999: Rosenberg E S; LaRosa L; Flynn T; Robbins G; Walker B D
Characterization of HIV-1-specific T-helper cells in acute and chronic infection.
Immunology letters 1999;66(1-3):89-93.
1999: Rosenberg E S; Caliendo A M; Walker B D
Acute HIV infection among patients tested for mononucleosis.
The New England journal of medicine 1999;340(12):969.
1999: Rodrigo A G; Shpaer E G; Delwart E L; Iversen A K; Gallo M V; Brojatsch J; Hirsch M S; Walker B D; Mullins J I
Coalescent estimates of HIV-1 generation time in vivo.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(5):2187-91.
1999: Merrill D P; Martinez-Picado J; Tremblay C; Sax P E; Boswell S L; Wong J T; D'Aquila R T; Walker B D; Hirsch M S
Improved CD4 lymphocyte outgrowth in response to effective antiretroviral therapy.
The Journal of infectious diseases 1999;179(2):345-51.
1999: Goulder P J; Rowland-Jones S L; McMichael A J; Walker B D
Anti-HIV cellular immunity: recent advances towards vaccine design.
AIDS (London, England) 1999;13 Suppl A():S121-36.
1998: Kalams S A; Walker B D
The critical need for CD4 help in maintaining effective cytotoxic T lymphocyte responses.
The Journal of experimental medicine 1998;188(12):2199-204.
1998: Jin X; Roberts C G; Nixon D F; Cao Y; Ho D D; Walker B D; Muldoon M; Korber B T; Koup R A
Longitudinal and cross-sectional analysis of cytotoxic T lymphocyte responses and their relationship to vertical human immunodeficiency virus transmission. ARIEL Project Investigators.
The Journal of infectious diseases 1998;178(5):1317-26.
1998: Rosenberg E S; Walker B D
HIV type 1-specific helper T cells: a critical host defense.
AIDS research and human retroviruses 1998;14 Suppl 2():S143-7.
1998: Brander C; Hartman K E; Trocha A K; Jones N G; Johnson R P; Korber B; Wentworth P; Buchbinder S P; Wolinsky S; Walker B D; Kalams S A
Lack of strong immune selection pressure by the immunodominant, HLA-A*0201-restricted cytotoxic T lymphocyte response in chronic human immunodeficiency virus-1 infection.
The Journal of clinical investigation 1998;101(11):2559-66.
1998: Walter J B; Garboczi D N; Fan Q R; Zhou X; Walker B D; Eisen H N
A mutant human beta2-microglobulin can be used to generate diverse multimeric class I peptide complexes as specific probes for T cell receptors.
Journal of immunological methods 1998;214(1-2):41-50.
1998: Wagner L; Yang O O; Garcia-Zepeda E A; Ge Y; Kalams S A; Walker B D; Pasternack M S; Luster A D
Beta-chemokines are released from HIV-1-specific cytolytic T-cell granules complexed to proteoglycans.
Nature 1998;391(6670):908-11.
1998: Collins K L; Chen B K; Kalams S A; Walker B D; Baltimore D
HIV-1 Nef protein protects infected primary cells against killing by cytotoxic T lymphocytes.
Nature 1998;391(6665):397-401.
1997: Rosenberg E S; Billingsley J M; Caliendo A M; Boswell S L; Sax P E; Kalams S A; Walker B D
Vigorous HIV-1-specific CD4+ T cell responses associated with control of viremia.
Science (New York, N.Y.) 1997;278(5342):1447-50.
1997: Cao H; Kanki P; Sankalé J L; Dieng-Sarr A; Mazzara G P; Kalams S A; Korber B; Mboup S; Walker B D
Cytotoxic T-lymphocyte cross-reactivity among different human immunodeficiency virus type 1 clades: implications for vaccine development.
Journal of virology 1997;71(11):8615-23.
1997: Koziel M J; Wong D K; Dudley D; Houghton M; Walker B D
Hepatitis C virus-specific cytolytic T lymphocyte and T helper cell responses in seronegative persons.
The Journal of infectious diseases 1997;176(4):859-66.
1997: Yang O O; Tran A C; Kalams S A; Johnson R P; Roberts M R; Walker B D
Lysis of HIV-1-infected cells and inhibition of viral replication by universal receptor T cells.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(21):11478-83.
1997: Threlkeld S C; Wentworth P A; Kalams S A; Wilkes B M; Ruhl D J; Keogh E; Sidney J; Southwood S; Walker B D; Sette A
Degenerate and promiscuous recognition by CTL of peptides presented by the MHC class I A3-like superfamily: implications for vaccine development.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(4):1648-57.
1997: Yang O O; Kalams S A; Trocha A; Cao H; Luster A; Johnson R P; Walker B D
Suppression of human immunodeficiency virus type 1 replication by CD8+ cells: evidence for HLA class I-restricted triggering of cytolytic and noncytolytic mechanisms.
Journal of virology 1997;71(4):3120-8.
1997: Walter J B; Brander C; Mammen M; Garboczi D N; Kalams S A; Whitesides G M; Walker B D; Eisen H N
Stimulation of human cytotoxic T cells with HIV-1-derived peptides presented by recombinant HLA-A2 peptide complexes.
International immunology 1997;9(3):451-9.
1997: Sipsas N V; Kalams S A; Trocha A; He S; Blattner W A; Walker B D; Johnson R P
Identification of type-specific cytotoxic T lymphocyte responses to homologous viral proteins in laboratory workers accidentally infected with HIV-1.
The Journal of clinical investigation 1997;99(4):752-62.
1997: Wilson C C; Kalams S A; Wilkes B M; Ruhl D J; Gao F; Hahn B H; Hanson I C; Luzuriaga K; Wolinsky S; Koup R; Buchbinder S P; Johnson R P; Walker B D
Overlapping epitopes in human immunodeficiency virus type 1 gp120 presented by HLA A, B, and C molecules: effects of viral variation on cytotoxic T-lymphocyte recognition.
Journal of virology 1997;71(2):1256-64.
1997: Yang O O; Walker B D
CD8+ cells in human immunodeficiency virus type I pathogenesis: cytolytic and noncytolytic inhibition of viral replication.
Advances in immunology 1997;66():273-311.
1996: Yang O O; Kalams S A; Rosenzweig M; Trocha A; Jones N; Koziel M; Walker B D; Johnson R P
Efficient lysis of human immunodeficiency virus type 1-infected cells by cytotoxic T lymphocytes.
Journal of virology 1996;70(9):5799-806.
1996: Harrer T; Harrer E; Kalams S A; Elbeik T; Staprans S I; Feinberg M B; Cao Y; Ho D D; Yilma T; Caliendo A M; Johnson R P; Buchbinder S P; Walker B D
Strong cytotoxic T cell and weak neutralizing antibody responses in a subset of persons with stable nonprogressing HIV type 1 infection.
AIDS research and human retroviruses 1996;12(7):585-92.
1996: Harrer T; Harrer E; Kalams S A; Barbosa P; Trocha A; Johnson R P; Elbeik T; Feinberg M B; Buchbinder S P; Walker B D
Cytotoxic T lymphocytes in asymptomatic long-term nonprogressing HIV-1 infection. Breadth and specificity of the response and relation to in vivo viral quasispecies in a person with prolonged infection and low viral load.
Journal of immunology (Baltimore, Md. : 1950) 1996;156(7):2616-23.
1996: Kalams S A; Johnson R P; Dynan M J; Hartman K E; Harrer T; Harrer E; Trocha A K; Blattner W A; Buchbinder S P; Walker B D
T cell receptor usage and fine specificity of human immunodeficiency virus 1-specific cytotoxic T lymphocyte clones: analysis of quasispecies recognition reveals a dominant response directed against a minor in vivo variant.
The Journal of experimental medicine 1996;183(4):1669-79.
1996: Harrer E; Harrer T; Barbosa P; Feinberg M; Johnson R P; Buchbinder S; Walker B D
Recognition of the highly conserved YMDD region in the human immunodeficiency virus type 1 reverse transcriptase by HLA-A2-restricted cytotoxic T lymphocytes from an asymptomatic long-term nonprogressor.
The Journal of infectious diseases 1996;173(2):476-9.
1995: Heinkelein M; Schneider-Schaulies J; Walker B D; Jassoy C
Inhibition of cytotoxicity and cytokine release of CD8+ HIV-specific cytotoxic T lymphocytes by pentoxifylline.
Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association 1995;10(4):417-24.
1995: Koziel M J; Dudley D; Afdhal N; Grakoui A; Rice C M; Choo Q L; Houghton M; Walker B D
HLA class I-restricted cytotoxic T lymphocytes specific for hepatitis C virus. Identification of multiple epitopes and characterization of patterns of cytokine release.
The Journal of clinical investigation 1995;96(5):2311-21.
1995: Iversen A K; Shpaer E G; Rodrigo A G; Hirsch M S; Walker B D; Sheppard H W; Merigan T C; Mullins J I
Persistence of attenuated rev genes in a human immunodeficiency virus type 1-infected asymptomatic individual.
Journal of virology 1995;69(9):5743-53.
1995: Hammond S A; Johnson R P; Kalams S A; Walker B D; Takiguchi M; Safrit J T; Koup R A; Siliciano R F
An epitope-selective, transporter associated with antigen presentation (TAP)-1/2-independent pathway and a more general TAP-1/2-dependent antigen-processing pathway allow recognition of the HIV-1 envelope glycoprotein by CD8+ CTL.
Journal of immunology (Baltimore, Md. : 1950) 1995;154(11):6140-56.
1995: Price P; Johnson R P; Scadden D T; Jassoy C; Rosenthal T; Kalams S; Walker B D
Cytotoxic CD8+ T lymphocytes reactive with human immunodeficiency virus-1 produce granulocyte/macrophage colony-stimulating factor and variable amounts of interleukins 2, 3, and 4 following stimulation with the cognate epitope.
Clinical immunology and immunopathology 1995;74(1):100-6.
1995: Jassoy C; Walker B D
T lymphocytes and their cytokines in human immunodeficiency virus (HIV) infection: implications for associated neoplasias.
Critical reviews in oncogenesis 1995;6(3-6):275-89.
1995: Kalams S A; Walker B D
Cytotoxic T lymphocytes and HIV-1 related neurologic disorders.
Current topics in microbiology and immunology 1995;202():79-88.
1994: Jassoy C; Heinkelein M; Klinker H; Walker B D
HIV type 1-specific cytotoxic T lymphocytes stimulate HLA class I and intercellular adhesion molecule type 1 expression and increase beta 2-microglobulin levels in vitro.
AIDS research and human retroviruses 1994;10(12):1685-93.
1994: Delwart E L; Sheppard H W; Walker B D; Goudsmit J; Mullins J I
Human immunodeficiency virus type 1 evolution in vivo tracked by DNA heteroduplex mobility assays.
Journal of virology 1994;68(10):6672-83.
1994: Tsomides T J; Aldovini A; Johnson R P; Walker B D; Young R A; Eisen H N
Naturally processed viral peptides recognized by cytotoxic T lymphocytes on cells chronically infected by human immunodeficiency virus type 1.
The Journal of experimental medicine 1994;180(4):1283-93.
1994: Johnson R P; Hammond S A; Trocha A; Siliciano R F; Walker B D
Induction of a major histocompatibility complex class I-restricted cytotoxic T-lymphocyte response to a highly conserved region of human immunodeficiency virus type 1 (HIV-1) gp120 in seronegative humans immunized with a candidate HIV-1 vaccine.
Journal of virology 1994;68(5):3145-53.
1994: Kalams S A; Johnson R P; Trocha A K; Dynan M J; Ngo H S; D'Aquila R T; Kurnick J T; Walker B D
Longitudinal analysis of T cell receptor (TCR) gene usage by human immunodeficiency virus 1 envelope-specific cytotoxic T lymphocyte clones reveals a limited TCR repertoire.
The Journal of experimental medicine 1994;179(4):1261-71.
1994: Walker B D
The rationale for immunotherapy in HIV-1 infection.
Journal of acquired immune deficiency syndromes 1994;7 Suppl 1():S6-13.
1994: Harrer E; Harrer T; Buchbinder S; Mann D L; Feinberg M; Yilma T; Johnson R P; Walker B D
HIV-1-specific cytotoxic T lymphocyte response in healthy, long-term nonprogressing seropositive persons.
AIDS research and human retroviruses 1994;10 Suppl 2():S77-8.
1994: Johnson R P; Hammond S A; Trocha A; Siliciano R F; Walker B D
Epitope specificity of MHC restricted cytotoxic T lymphocytes induced by candidate HIV-1 vaccine.
AIDS research and human retroviruses 1994;10 Suppl 2():S73-5.
1994: Johnson R P; Walker B D
Cytotoxic T lymphocytes in human immunodeficiency virus infection: responses to structural proteins.
Current topics in microbiology and immunology 1994;189():35-63.
1993: Koziel M J; Dudley D; Afdhal N; Choo Q L; Houghton M; Ralston R; Walker B D
Hepatitis C virus (HCV)-specific cytotoxic T lymphocytes recognize epitopes in the core and envelope proteins of HCV.
Journal of virology 1993;67(12):7522-32.
1993: Harrer T; Jassoy C; Harrer E; Johnson R P; Walker B D
Induction of HIV-1 replication in a chronically infected T-cell line by cytotoxic T lymphocytes.
Journal of acquired immune deficiency syndromes 1993;6(8):865-71.
1993: Jassoy C; Harrer T; Rosenthal T; Navia B A; Worth J; Johnson R P; Walker B D
Human immunodeficiency virus type 1-specific cytotoxic T lymphocytes release gamma interferon, tumor necrosis factor alpha (TNF-alpha), and TNF-beta when they encounter their target antigens.
Journal of virology 1993;67(5):2844-52.
1993: Johnson R P; Trocha A; Buchanan T M; Walker B D
Recognition of a highly conserved region of human immunodeficiency virus type 1 gp120 by an HLA-Cw4-restricted cytotoxic T-lymphocyte clone.
Journal of virology 1993;67(1):438-45.
1992: Koziel M J; Dudley D; Wong J T; Dienstag J; Houghton M; Ralston R; Walker B D
Intrahepatic cytotoxic T lymphocytes specific for hepatitis C virus in persons with chronic hepatitis.
Journal of immunology (Baltimore, Md. : 1950) 1992;149(10):3339-44.
1992: Jassoy C; Johnson R P; Navia B A; Worth J; Walker B D
Detection of a vigorous HIV-1-specific cytotoxic T lymphocyte response in cerebrospinal fluid from infected persons with AIDS dementia complex.
Journal of immunology (Baltimore, Md. : 1950) 1992;149(9):3113-9.
1992: Johnson R P; Trocha A; Buchanan T M; Walker B D
Identification of overlapping HLA class I-restricted cytotoxic T cell epitopes in a conserved region of the human immunodeficiency virus type 1 envelope glycoprotein: definition of minimum epitopes and analysis of the effects of sequence variation.
The Journal of experimental medicine 1992;175(4):961-71.
1992: Koziel M J; Walker B D
Viruses, chemotherapy and immunity.
Parasitology 1992;105 Suppl():S85-92.
1991: Tsomides T J; Walker B D; Eisen H N
An optimal viral peptide recognized by CD8+ T cells binds very tightly to the restricting class I major histocompatibility complex protein on intact cells but not to the purified class I protein.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(24):11276-80.
1991: Johnson R P; Trocha A; Yang L; Mazzara G P; Panicali D L; Buchanan T M; Walker B D
HIV-1 gag-specific cytotoxic T lymphocytes recognize multiple highly conserved epitopes. Fine specificity of the gag-specific response defined by using unstimulated peripheral blood mononuclear cells and cloned effector cells.
Journal of immunology (Baltimore, Md. : 1950) 1991;147(5):1512-21.
1991: Johnson R P; Walker B D
Identification of HIV-1 cytotoxic T-lymphocyte epitopes and implications for vaccine development.
Biotechnology therapeutics 1991;2(1-2):137-46.
1990: Walker B D; Plata F
Cytotoxic T lymphocytes against HIV.
AIDS (London, England) 1990;4(3):177-84.
1989: Walker B D; Flexner C; Birch-Limberger K; Fisher L; Paradis T J; Aldovini A; Young R; Moss B; Schooley R T
Long-term culture and fine specificity of human cytotoxic T-lymphocyte clones reactive with human immunodeficiency virus type 1.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(23):9514-8.
1989: Johnson V A; Barlow M A; Chou T C; Fisher R A; Walker B D; Hirsch M S; Schooley R T
Synergistic inhibition of human immunodeficiency virus type 1 (HIV-1) replication in vitro by recombinant soluble CD4 and 3'-azido-3'-deoxythymidine.
The Journal of infectious diseases 1989;159(5):837-44.
1989: Johnson V A; Walker B D; Barlow M A; Paradis T J; Chou T C; Hirsch M S
Synergistic inhibition of human immunodeficiency virus type 1 and type 2 replication in vitro by castanospermine and 3'-azido-3'-deoxythymidine.
Antimicrobial agents and chemotherapy 1989;33(1):53-7.
1988: Walker B D; Flexner C; Paradis T J; Fuller T C; Hirsch M S; Schooley R T; Moss B
HIV-1 reverse transcriptase is a target for cytotoxic T lymphocytes in infected individuals.
Science (New York, N.Y.) 1988;240(4848):64-6.
1987: Walker B D; Kowalski M; Goh W C; Kozarsky K; Krieger M; Rosen C; Rohrschneider L; Haseltine W A; Sodroski J
Inhibition of human immunodeficiency virus syncytium formation and virus replication by castanospermine.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(22):8120-4.
1987: Walker B D; Chakrabarti S; Moss B; Paradis T J; Flynn T; Durno A G; Blumberg R S; Kaplan J C; Hirsch M S; Schooley R T
HIV-specific cytotoxic T lymphocytes in seropositive individuals.
Nature 1987;328(6128):345-8.

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