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Brian Walker

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Tiina Kipari; Dawn E W Livingstone; Tak-Yung Man; Eileen Miller; Tijana Mitic; Kay Samuel; John S Savill; Christopher Schrecker; Ruth Andrew; M Amine Bouhlel; Karen E Chapman; Giulia Chinetti-Gbaguidi; Agnes E Coutinho; Patrick W F Hadoke; Javaid Iqbal; Bart Staels; Katie M Sullivan; Brian R Walker; Christopher I White; Zhenguang Zhang; Jonathan R Seckl
11β-hydroxysteroid dehydrogenase type 1 deficiency in bone marrow-derived cells reduces atherosclerosis.
Tijana Mitić; Brian R Walker; Ruth Andrew; Patrick W F Hadoke
11β-Hydroxysteroid dehydrogenase type 1 contributes to the regulation of 7-oxysterol levels in the arterial wall through the inter-conversion of 7-ketocholesterol and 7β-hydroxycholesterol.
Javaid Iqbal; Lucinda Low; Linsay J Macdonald; Jonathan R Seckl; Brian R Walker; Christopher W Yau; Patrick W F Hadoke
Contribution of endogenous glucocorticoids and their intravascular metabolism by 11β-HSDs to postangioplasty neointimal proliferation in mice.

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2013: Tiina Kipari; Dawn E W Livingstone; Tak-Yung Man; Eileen Miller; Tijana Mitic; Kay Samuel; John S Savill; Christopher Schrecker; Ruth Andrew; M Amine Bouhlel; Karen E Chapman; Giulia Chinetti-Gbaguidi; Agnes E Coutinho; Patrick W F Hadoke; Javaid Iqbal; Bart Staels; Katie M Sullivan; Brian R Walker; Christopher I White; Zhenguang Zhang; Jonathan R Seckl
11β-hydroxysteroid dehydrogenase type 1 deficiency in bone marrow-derived cells reduces atherosclerosis.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2013;27(4):1519-31.
2013: Tijana Mitić; Brian R Walker; Ruth Andrew; Patrick W F Hadoke
11β-Hydroxysteroid dehydrogenase type 1 contributes to the regulation of 7-oxysterol levels in the arterial wall through the inter-conversion of 7-ketocholesterol and 7β-hydroxycholesterol.
Biochimie 2013;95(3):548-55.
2012: Javaid Iqbal; Lucinda Low; Linsay J Macdonald; Jonathan R Seckl; Brian R Walker; Christopher W Yau; Patrick W F Hadoke
Contribution of endogenous glucocorticoids and their intravascular metabolism by 11β-HSDs to postangioplasty neointimal proliferation in mice.
Endocrinology 2012;153(12):5896-905.
2012: Rebecca M Reynolds; Alison V Sears; Mark W J Strachan; Brian R Walker; Rachel M Williamson; Ian J Deary; Javier Labad; Gordon D O Lowe; Jackie F Price
Glucocorticoid treatment and impaired mood, memory and metabolism in people with diabetes: the Edinburgh Type 2 Diabetes Study.
European journal of endocrinology / European Federation of Endocrine Societies 2012;166(5):861-8.
2012: Mark Nixon; Jonathan R Seckl; Roland H Stimson; Deborah J Wake; Ruth Andrew; Karen E Chapman; Cristina L Esteves; Dawn E Livingstone; Brian R Walker
Salicylate downregulates 11β-HSD1 expression in adipose tissue in obese mice and in humans, mediating insulin sensitization.
Diabetes 2012;61(4):790-6.
2012: Sophie Turban; Brian R Walker; Scott P Webster; Donald R Dunbar; Xiaoxia Liu; John J Mullins; Lynne Ramage; Jonathan R Seckl; Nicholas M Morton
Optimal elevation of β-cell 11β-hydroxysteroid dehydrogenase type 1 is a compensatory mechanism that prevents high-fat diet-induced β-cell failure.
Diabetes 2012;61(3):642-52.
2012: Zoi Michailidou; Eileen Miller; Nicholas M Morton; Peter J Ratcliffe; Joerg Schrader; Patrick W F Hadoke; John P Iredale; Sophie Turban; Brian R Walker; Xiantong Zou; Jonathan R Seckl
Increased angiogenesis protects against adipose hypoxia and fibrosis in metabolic disease-resistant 11β-hydroxysteroid dehydrogenase type 1 (HSD1)-deficient mice.
The Journal of biological chemistry 2012;287(6):4188-97.
2012: Javier Labad; Jackie F Price; Rebecca M Reynolds; Naveed Sattar; Jonathan R Seckl; Mark W J Strachan; Brian R Walker; Ian J Deary; F Gerry R Fowkes
Leptin levels and depressive symptoms in people with type 2 diabetes: the edinburgh type 2 diabetes study.
Psychosomatic medicine 2012;74(1):39-45.
2011: Julia H Goedecke; Philip Hayes; Kevin Adams; Joel A Dave; Juliet Evans; Dheshnie Keswell; Estelle V Lambert; Naomi S Levitt; Dawn E W Livingstone; Tommy Olsson; Jonathan R Seckl; Roland H Stimson; Hendriena Victor; Brian R Walker; Steven E Kahn
Reduced gluteal expression of adipogenic and lipogenic genes in Black South African women is associated with obesity-related insulin resistance.
The Journal of clinical endocrinology and metabolism 2011;96(12):E2029-33.
2011: S Forbes; S D Taylor-Robinson; N Patel; P Allan; Brian R Walker; D G Johnston
Increased prevalence of non-alcoholic fatty liver disease in European women with a history of gestational diabetes.
Diabetologia 2011;54(3):641-7.
2011: David P Macfarlane; Xiantong Zou; Ruth Andrew; Nicholas M Morton; Dawn E W Livingstone; Rebecca L Aucott; Moffat J Nyirenda; John P Iredale; Brian R Walker
Metabolic pathways promoting intrahepatic fatty acid accumulation in methionine and choline deficiency: implications for the pathogenesis of steatohepatitis.
American journal of physiology. Endocrinology and metabolism 2011;300(2):E402-9.
2011: Nicholas S Kirkby; Lucinda Low; Jonathan R Seckl; Brian R Walker; David J Webb; Patrick W F Hadoke
Quantitative 3-dimensional imaging of murine neointimal and atherosclerotic lesions by optical projection tomography.
PloS one 2011;6(2):e16906.
2010: Thayalini Ramaesh; James J Logie; Antonia K Roseweir; Robert P Millar; Brian R Walker; Patrick W F Hadoke; Rebecca M Reynolds
Kisspeptin-10 inhibits angiogenesis in human placental vessels ex vivo and endothelial cells in vitro.
Endocrinology 2010;151(12):5927-34.
2010: Karen Sooy; Scott P Webster; June Noble; Margaret Binnie; Brian R Walker; Jonathan R Seckl; Joyce L W Yau
Partial deficiency or short-term inhibition of 11beta-hydroxysteroid dehydrogenase type 1 improves cognitive function in aging mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010;30(41):13867-72.
2010: Katherine A Hughes; Rebecca M Reynolds; Ruth Andrew; Hilary Critchley; Brian R Walker
Glucocorticoids turn over slowly in human adipose tissue in vivo.
The Journal of clinical endocrinology and metabolism 2010;95(10):4696-702.
2010: Sara J McSweeney; Patrick W F Hadoke; Agnieszka M Kozak; Gary R Small; Hiba Khaled; Brian R Walker; Gillian A Gray
Improved heart function follows enhanced inflammatory cell recruitment and angiogenesis in 11betaHSD1-deficient mice post-MI.
Cardiovascular research 2010;88(1):159-67.
2010: Scott P Webster; Margaret Binnie; Kirsty M M McConnell; Karen Sooy; Peter Ward; Michael F Greaney; Andy Vinter; T David Pallin; Hazel J Dyke; Matthew I A Gill; Ines Warner; Jonathan R Seckl; Brian R Walker
Modulation of 11beta-hydroxysteroid dehydrogenase type 1 activity by 1,5-substituted 1H-tetrazoles.
Bioorganic & medicinal chemistry letters 2010;20(11):3265-71.
2010: Alison D McNeilly; David P Macfarlane; Emmett O'Flaherty; Dawn E Livingstone; Tijana Mitić; Kirsty M McConnell; Scott M McKenzie; Eleanor Davies; Rebecca M Reynolds; Helle C Thiesson; Ole Skøtt; Brian R Walker; Ruth Andrew
Bile acids modulate glucocorticoid metabolism and the hypothalamic-pituitary-adrenal axis in obstructive jaundice.
Journal of hepatology 2010;52(5):705-11.
2010: Amanda J Drake; Peter J Raubenheimer; David Kerrigan; Kerry J McInnes; Jonathan R Seckl; Brian R Walker
Prenatal dexamethasone programs expression of genes in liver and adipose tissue and increased hepatic lipid accumulation but not obesity on a high-fat diet.
Endocrinology 2010;151(4):1581-7.
2010: Rebecca M Reynolds; Javier Labad; Mark W J Strachan; Anke Braun; F Gerry R Fowkes; Amanda J Lee; Brian M Frier; Jonathan R Seckl; Brian R Walker; Jackie F Price
Elevated fasting plasma cortisol is associated with ischemic heart disease and its risk factors in people with type 2 diabetes: the Edinburgh type 2 diabetes study.
The Journal of clinical endocrinology and metabolism 2010;95(4):1602-8.
2010: Rebecca M Reynolds; Mark W J Strachan; Javier Labad; Amanda J Lee; Brian M Frier; F Gerald Fowkes; Rory Mitchell; Jonathan R Seckl; Ian J Deary; Brian R Walker; Jackie F Price
Morning cortisol levels and cognitive abilities in people with type 2 diabetes: the Edinburgh type 2 diabetes study.
Diabetes care 2010;33(4):714-20.
2010: Rebecca M Reynolds; Brian R Walker; Sally Haw; David E Newby; Daniel F Mackay; Stuart M Cobbe; Alastair C H Pell; Colin Fischbacher; Stuart Pringle; David Murdoch; Frank Dunn; Keith Oldroyd; Paul Macintyre; Brian O'Rourke; Jill P Pell
Low serum cortisol predicts early death after acute myocardial infarction.
Critical care medicine 2010;38(3):973-5.
2010: J Labad; J F Price; Mark W J Strachan; F G R Fowkes; J Ding; Ian J Deary; A J Lee; Brian M Frier; Jonathan R Seckl; Brian R Walker; R M Reynolds
Symptoms of depression but not anxiety are associated with central obesity and cardiovascular disease in people with type 2 diabetes: the Edinburgh Type 2 Diabetes Study.
Diabetologia 2010;53(3):467-71.
2010: James J Logie; Sadaf Ali; Kathryn M Marshall; Margarete M S Heck; Brian R Walker; Patrick W F Hadoke
Glucocorticoid-mediated inhibition of angiogenic changes in human endothelial cells is not caused by reductions in cell proliferation or migration.
PloS one 2010;5(12):e14476.
2010: Roland H Stimson; Gerald E Lobley; Ioanna Maraki; Nicholas M Morton; Ruth Andrew; Brian R Walker
Effects of proportions of dietary macronutrients on glucocorticoid metabolism in diet-induced obesity in rats.
PloS one 2010;5(1):e8779.
2010: Elise L V Malavasi; Val Kelly; Nikita Nath; Alessandra Gambineri; Rachel S Dakin; Uberto Pagotto; Renato Pasquali; Brian R Walker; Karen E Chapman
Functional effects of polymorphisms in the human gene encoding 11 beta-hydroxysteroid dehydrogenase type 1 (11 beta-HSD1): a sequence variant at the translation start of 11 beta-HSD1 alters enzyme levels.
Endocrinology 2010;151(1):195-202.
2009: Julia H Goedecke; Naomi S Levitt; Estelle V Lambert; Kristina M Utzschneider; Mirjam V Faulenbach; Joel A Dave; Sacha West; Hendriena Victor; Juliet Evans; Tommy Olsson; Brian R Walker; Jonathan R Seckl; Steven E Kahn
Differential effects of abdominal adipose tissue distribution on insulin sensitivity in black and white South African women.
Obesity (Silver Spring, Md.) 2009;17(8):1506-12.
2009: Rebecca M Reynolds; B Ilyas; J F Price; F G R Fowkes; David E Newby; David J Webb; Brian R Walker
Circulating plasma cortisol concentrations are not associated with coronary artery disease or peripheral vascular disease.
QJM : monthly journal of the Association of Physicians 2009;102(7):469-75.
2009: Rebecca M Reynolds; Brian R Walker; David I W Phillips; Elaine M Dennison; Robert Fraser; Scott M Mackenzie; Eleanor Davies; John M Connell
Programming of hypertension: associations of plasma aldosterone in adult men and women with birthweight, cortisol, and blood pressure.
Hypertension 2009;53(6):932-6.
2009: Dawn E W Livingstone; Sarah L Grassick; Gillian L Currie; Brian R Walker; Ruth Andrew
Dysregulation of glucocorticoid metabolism in murine obesity: comparable effects of leptin resistance and deficiency.
The Journal of endocrinology 2009;201(2):211-8.
2009: Julia H Goedecke; Joel A Dave; Mirjam V Faulenbach; Kristina M Utzschneider; Estelle V Lambert; Sacha West; Malcolm Collins; Tommy Olsson; Brian R Walker; Jonathan R Seckl; Steven E Kahn; Naomi S Levitt
Insulin response in relation to insulin sensitivity: an appropriate beta-cell response in black South African women.
Diabetes care 2009;32(5):860-5.
2009: Michael T Rae; Amirah Mohamad; Deborah Price; Patrick W F Hadoke; Brian R Walker; J Ian Mason; Stephen G Hillier; Hilary Critchley
Cortisol inactivation by 11beta-hydroxysteroid dehydrogenase-2 may enhance endometrial angiogenesis via reduced thrombospondin-1 in heavy menstruation.
The Journal of clinical endocrinology and metabolism 2009;94(4):1443-50.
2009: Cecilia Mattsson; Rebecca M Reynolds; Kotryna Simonyte; Tommy Olsson; Brian R Walker
Combined receptor antagonist stimulation of the hypothalamic-pituitary-adrenal axis test identifies impaired negative feedback sensitivity to cortisol in obese men.
The Journal of clinical endocrinology and metabolism 2009;94(4):1347-52.
2009: Patrick W F Hadoke; Javaid Iqbal; Brian R Walker
Therapeutic manipulation of glucocorticoid metabolism in cardiovascular disease.
British journal of pharmacology 2009;156(5):689-712.
2009: Natalie Z M Homer; Rebecca M Reynolds; Cecilia Mattsson; Matthew A Bailey; Brian R Walker; Ruth Andrew
Quantitative analysis of RU38486 (mifepristone) by HPLC triple quadrupole mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2009;877(5-6):497-501.
2009: Therése Andersson; Kotryna Simonyte; Ruth Andrew; Magnus Strand; Jonas Burén; Brian R Walker; Cecilia Mattsson; Tommy Olsson
Tissue-specific increases in 11beta-hydroxysteroid dehydrogenase type 1 in normal weight postmenopausal women.
PloS one 2009;4(12):e8475.
2009: Roland H Stimson; Jonas Andersson; Ruth Andrew; Doris N Redhead; Fredrik Karpe; Peter C Hayes; Tommy Olsson; Brian R Walker
Cortisol release from adipose tissue by 11beta-hydroxysteroid dehydrogenase type 1 in humans.
Diabetes 2009;58(1):46-53.
2008: David P Macfarlane; Shareen Forbes; Brian R Walker
Glucocorticoids and fatty acid metabolism in humans: fuelling fat redistribution in the metabolic syndrome.
The Journal of endocrinology 2008;197(2):189-204.
2008: Katherine A Hughes; Scott P Webster; Brian R Walker
11-Beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) inhibitors in type 2 diabetes mellitus and obesity.
Expert opinion on investigational drugs 2008;17(4):481-96.
2007: Brian R Walker
Glucocorticoids and cardiovascular disease.
European journal of endocrinology / European Federation of Endocrine Societies 2007;157(5):545-59.
2007: Roland H Stimson; Alexandra M Johnstone; Natalie Z M Homer; Deborah J Wake; Nicholas M Morton; Ruth Andrew; Gerald E Lobley; Brian R Walker
Dietary macronutrient content alters cortisol metabolism independently of body weight changes in obese men.
The Journal of clinical endocrinology and metabolism 2007;92(11):4480-4.
2007: Pascal Barat; Dawn E W Livingstone; Caroline M C Elferink; C Rachel McDonnell; Brian R Walker; Ruth Andrew
Effects of gonadectomy on glucocorticoid metabolism in obese Zucker rats.
Endocrinology 2007;148(10):4836-43.
2007: Roland H Stimson; Brian R Walker
Glucocorticoids and 11beta-hydroxysteroid dehydrogenase type 1 in obesity and the metabolic syndrome.
Minerva endocrinologica 2007;32(3):141-59.
2007: Anna R Dover; Patrick W F Hadoke; Brian R Walker; David E Newby
Acute effects of glucocorticoids on endothelial fibrinolytic and vasodilator function in humans.
Journal of cardiovascular pharmacology 2007;50(3):321-6.
2007: Rebecca M Reynolds; Brian R Walker
Can cortisol predict the future in obesity?
Clinical endocrinology 2007;67(1):1-2.
2007: Scott P Webster; Peter Ward; Margaret Binnie; Eilidh Craigie; Kirsty M M McConnell; Karen Sooy; Andy Vinter; Jonathan R Seckl; Brian R Walker
Discovery and biological evaluation of adamantyl amide 11beta-HSD1 inhibitors.
Bioorganic & medicinal chemistry letters 2007;17(10):2838-43.
2007: Zoi Michailidou; Michael D Jensen; Daniel A Dumesic; Karen E Chapman; Jonathan R Seckl; Brian R Walker; Nicholas M Morton
Omental 11beta-hydroxysteroid dehydrogenase 1 correlates with fat cell size independently of obesity.
Obesity (Silver Spring, Md.) 2007;15(5):1155-63.
2007: Pascal Barat; Michelle Gayard-Cros; Ruth Andrew; Jean-Benoît Corcuff; Béatrice Jouret; Nicole Barthe; Paul Perez; Christine Germain; Maïthé Tauber; Brian R Walker; Pierre Mormede; Martine Duclos
Truncal distribution of fat mass, metabolic profile and hypothalamic-pituitary adrenal axis activity in prepubertal obese children.
The Journal of pediatrics 2007;150(5):535-9, 539.e1.
2007: Deborah J Wake; Roland H Stimson; Garry D Tan; Natalie Z M Homer; Ruth Andrew; Fredrik Karpe; Brian R Walker
Effects of peroxisome proliferator-activated receptor-alpha and -gamma agonists on 11beta-hydroxysteroid dehydrogenase type 1 in subcutaneous adipose tissue in men.
The Journal of clinical endocrinology and metabolism 2007;92(5):1848-56.
2007: Deborah J Wake; Magnus Strand; Eva Rask; Jukka Westerbacka; Dawn E W Livingstone; Stefan Soderberg; Ruth Andrew; Hannele Yki-Jarvinen; Tommy Olsson; Brian R Walker
Intra-adipose sex steroid metabolism and body fat distribution in idiopathic human obesity.
Clinical endocrinology 2007;66(3):440-6.
2007: Brian R Walker
Extra-adrenal regeneration of glucocorticoids by 11beta-hydroxysteroid dehydrogenase type 1: physiological regulator and pharmacological target for energy partitioning.
The Proceedings of the Nutrition Society 2007;66(1):1-8.
2007: Anna R Dover; Patrick W F Hadoke; Linsay J Macdonald; Eileen Miller; David E Newby; Brian R Walker
Intravascular glucocorticoid metabolism during inflammation and injury in mice.
Endocrinology 2007;148(1):166-72.
2006: Brian R Walker
Cortisol--cause and cure for metabolic syndrome?
Diabetic medicine : a journal of the British Diabetic Association 2006;23(12):1281-8.
2006: Brian R Walker; Ruth Andrew
Tissue production of cortisol by 11beta-hydroxysteroid dehydrogenase type 1 and metabolic disease.
Annals of the New York Academy of Sciences 2006;1083():165-84.
2006: Deborah J Wake; Natalie Z M Homer; Ruth Andrew; Brian R Walker
Acute in vivo regulation of 11beta-hydroxysteroid dehydrogenase type 1 activity by insulin and intralipid infusions in humans.
The Journal of clinical endocrinology and metabolism 2006;91(11):4682-8.
2006: Juraj Koska; Barbora de Courten; Deborah J Wake; Saraswathy Nair; Brian R Walker; Joy C Bunt; Paska A Permana; Robert S Lindsay; P Antonio Tataranni
11beta-hydroxysteroid dehydrogenase type 1 in adipose tissue and prospective changes in body weight and insulin resistance.
Obesity (Silver Spring, Md.) 2006;14(9):1515-22.
2006: Julia H Goedecke; Deborah J Wake; Naomi S Levitt; Estelle V Lambert; M R Collins; Nicholas M Morton; Ruth Andrew; Jonathan R Seckl; Brian R Walker
Glucocorticoid metabolism within superficial subcutaneous rather than visceral adipose tissue is associated with features of the metabolic syndrome in South African women.
Clinical endocrinology 2006;65(1):81-7.
2006: Peter J Raubenheimer; Moffat J Nyirenda; Brian R Walker
A choline-deficient diet exacerbates fatty liver but attenuates insulin resistance and glucose intolerance in mice fed a high-fat diet.
Diabetes 2006;55(7):2015-20.
2006: Rebecca M Reynolds; Colin Fischbacher; Raj Bhopal; Christopher D Byrne; Martin White; Nigel Unwin; Brian R Walker
Differences in cortisol concentrations in South Asian and European men living in the United Kingdom.
Clinical endocrinology 2006;64(5):530-4.
2006: Patrick W F Hadoke; R S Lindsay; Jonathan R Seckl; Brian R Walker; Christopher J Kenyon
Altered vascular contractility in adult female rats with hypertension programmed by prenatal glucocorticoid exposure.
The Journal of endocrinology 2006;188(3):435-42.
2006: Patrick W F Hadoke; Linsay J Macdonald; J J Logie; G R Small; Anna R Dover; Brian R Walker
Intra-vascular glucocorticoid metabolism as a modulator of vascular structure and function.
Cellular and molecular life sciences : CMLS 2006;63(5):565-78.
2006: Deborah J Wake; Brian R Walker
Inhibition of 11beta-hydroxysteroid dehydrogenase type 1 in obesity.
Endocrine 2006;29(1):101-8.
2006: Ian J Deary; Caroline Hayward; Paska A Permana; Saraswathy Nair; LAWRENCE JEFFREY WHALLEY; John M Starr; Karen E Chapman; Brian R Walker; Jonathan R Seckl
Polymorphisms in the gene encoding 11B-hydroxysteroid dehydrogenase type 1 (HSD11B1) and lifetime cognitive change.
Neuroscience letters 2006;393(1):74-7.
2005: Dawn E W Livingstone; Kerry J McInnes; Brian R Walker; Ruth Andrew
Increased A-ring reduction of glucocorticoids in obese Zucker rats: effects of insulin sensitization.
Obesity research 2005;13(9):1523-6.
2005: Rebecca M Reynolds; E M Dennison; Brian R Walker; Holly E Syddall; Peter J Wood; Ruth Andrew; David I W Phillips; C Cooper
Cortisol secretion and rate of bone loss in a population-based cohort of elderly men and women.
Calcified tissue international 2005;77(3):134-8.
2005: Gary R Small; Patrick W F Hadoke; Isam Sharif; Anna R Dover; Danielle Armour; Christopher J Kenyon; Gillian A Gray; Brian R Walker
Preventing local regeneration of glucocorticoids by 11beta-hydroxysteroid dehydrogenase type 1 enhances angiogenesis.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(34):12165-70.
2005: Rebecca M Reynolds; Loai A Shakerdi; K Sandhu; A M Wallace; Peter J Wood; Brian R Walker
The utility of three different methods for measuring urinary 18-hydroxycortisol in the differential diagnosis of suspected primary hyperaldosteronism.
European journal of endocrinology / European Federation of Endocrine Societies 2005;152(6):903-7.
2005: Ruth Andrew; Jukka Westerbacka; John Wahren; Hannele Yki-Järvinen; Brian R Walker
The contribution of visceral adipose tissue to splanchnic cortisol production in healthy humans.
Diabetes 2005;54(5):1364-70.
2005: Thekkepat C Sandeep; Ruth Andrew; Natalie Z M Homer; Robert C Andrews; Ken Smith; Brian R Walker
Increased in vivo regeneration of cortisol in adipose tissue in human obesity and effects of the 11beta-hydroxysteroid dehydrogenase type 1 inhibitor carbenoxolone.
Diabetes 2005;54(3):872-9.
2005: Rebecca M Reynolds; Brian R Walker; Holly E Syddall; Ruth Andrew; Peter J Wood; David I W Phillips
Is there a gender difference in the associations of birthweight and adult hypothalamic-pituitary-adrenal axis activity?
European journal of endocrinology / European Federation of Endocrine Societies 2005;152(2):249-53.
2005: Amanda J Drake; Dawn E W Livingstone; Ruth Andrew; Jonathan R Seckl; Nicholas M Morton; Brian R Walker
Reduced adipose glucocorticoid reactivation and increased hepatic glucocorticoid clearance as an early adaptation to high-fat feeding in Wistar rats.
Endocrinology 2005;146(2):913-9.
2005: Amanda J Drake; Brian R Walker; Jonathan R Seckl
Intergenerational consequences of fetal programming by in utero exposure to glucocorticoids in rats.
American journal of physiology. Regulatory, integrative and comparative physiology 2005;288(1):R34-8.
2004: Jonathan R Seckl; Brian R Walker
11beta-hydroxysteroid dehydrogenase type 1 as a modulator of glucocorticoid action: from metabolism to memory.
Trends in endocrinology and metabolism: TEM 2004;15(9):418-24.
2004: Jussi Sutinen; Katja Kannisto; Elena Korsheninnikova; Tuulikki Nyman; Ewa Ehrenborg; Ruth Andrew; Deborah J Wake; Anders Hamsten; Brian R Walker; Hannele Yki-Järvinen
In the lipodystrophy associated with highly active antiretroviral therapy, pseudo-Cushing's syndrome is associated with increased regeneration of cortisol by 11beta-hydroxysteroid dehydrogenase type 1 in adipose tissue.
Diabetologia 2004;47(10):1668-71.
2004: Saraswathy Nair; Y H Lee; Robert S Lindsay; Brian R Walker; P Antonio Tataranni; C Bogardus; Leslie J Baier; Paska A Permana
11beta-Hydroxysteroid dehydrogenase Type 1: genetic polymorphisms are associated with Type 2 diabetes in Pima Indians independently of obesity and expression in adipocyte and muscle.
Diabetologia 2004;47(6):1088-95.
2004: Kerry J McInnes; Christopher J Kenyon; Karen E Chapman; Dawn E W Livingstone; Linsay J Macdonald; Brian R Walker; Ruth Andrew
5alpha-reduced glucocorticoids, novel endogenous activators of the glucocorticoid receptor.
The Journal of biological chemistry 2004;279(22):22908-12.
2004: Brian R Walker
Is "Cushing's disease of the omentum" an affliction of mouse and men?
Diabetologia 2004;47(5):767-9.
2004: Alasdair M J MacLullich; Ian J Deary; John M Starr; Brian R Walker; Jonathan R Secki
Glycosylated hemoglobin levels in healthy elderly nondiabetic men are negatively associated with verbal memory.
Journal of the American Geriatrics Society 2004;52(5):848-9.
2004: Thekkepat C Sandeep; Joyce L W Yau; Alasdair M J MacLullich; June Noble; Ian J Deary; Brian R Walker; Jonathan R Seckl
11Beta-hydroxysteroid dehydrogenase inhibition improves cognitive function in healthy elderly men and type 2 diabetics.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(17):6734-9.
2004: Nicholas M Morton; Janice M Paterson; Hiroaki Masuzaki; Megan C Holmes; Bart Staels; Catherine Fievet; Brian R Walker; Jeffrey S Flier; John J Mullins; Jonathan R Seckl
Novel adipose tissue-mediated resistance to diet-induced visceral obesity in 11 beta-hydroxysteroid dehydrogenase type 1-deficient mice.
Diabetes 2004;53(4):931-8.
2004: R John Irving; Angela C Shore; Neville R Belton; Robert A Elton; David J Webb; Brian R Walker
Low birth weight predicts higher blood pressure but not dermal capillary density in two populations.
Hypertension 2004;43(3):610-3.
2004: Deborah J Wake; Brian R Walker
11 beta-hydroxysteroid dehydrogenase type 1 in obesity and the metabolic syndrome.
Molecular and cellular endocrinology 2004;215(1-2):45-54.
2004: Jonathan R Seckl; Nicholas M Morton; Karen E Chapman; Brian R Walker
Glucocorticoids and 11beta-hydroxysteroid dehydrogenase in adipose tissue.
Recent progress in hormone research 2004;59():359-93.
2004: Brian R Walker
11beta-hydroxysteroid dehydrogenase type 1 in obesity.
Obesity research 2004;12(1):1-3.
2004: Amanda J Drake; Brian R Walker
The intergenerational effects of fetal programming: non-genomic mechanisms for the inheritance of low birth weight and cardiovascular risk.
The Journal of endocrinology 2004;180(1):1-16.
2003: Brian R Walker; Jonathan R Seckl
11beta-hydroxysteroid dehydrogenase type 1 as a novel therapeutic target in metabolic and neurodegenerative disease.
Expert opinion on therapeutic targets 2003;7(6):771-83.
2003: John Stokes; Brian R Walker; Jill C Campbell; Jonathan R Seckl; Colm O'Brien; Ruth Andrew
Altered peripheral sensitivity to glucocorticoids in primary open-angle glaucoma.
Investigative ophthalmology & visual science 2003;44(12):5163-7.
2003: Jukka Westerbacka; Hannele Yki-Järvinen; Satu Vehkavaara; Anna-Maija Häkkinen; Ruth Andrew; Deborah J Wake; Jonathan R Seckl; Brian R Walker
Body fat distribution and cortisol metabolism in healthy men: enhanced 5beta-reductase and lower cortisol/cortisone metabolite ratios in men with fatty liver.
The Journal of clinical endocrinology and metabolism 2003;88(10):4924-31.
2003: Clare Christy; Patrick W F Hadoke; Janice M Paterson; John J Mullins; Jonathan R Seckl; Brian R Walker
11beta-hydroxysteroid dehydrogenase type 2 in mouse aorta: localization and influence on response to glucocorticoids.
Hypertension 2003;42(4):580-7.
2003: Deborah J Wake; Eva Rask; Dawn E W Livingstone; Siv Söderberg; Tommy Olsson; Brian R Walker
Local and systemic impact of transcriptional up-regulation of 11beta-hydroxysteroid dehydrogenase type 1 in adipose tissue in human obesity.
The Journal of clinical endocrinology and metabolism 2003;88(8):3983-8.
2003: Cecilia Mattsson; Maggie Lai; June Noble; Eoin McKinney; Joyce L Yau; Jonathan R Seckl; Brian R Walker
Obese Zucker rats have reduced mineralocorticoid receptor and 11beta-hydroxysteroid dehydrogenase type 1 expression in hippocampus-implications for dysregulation of the hypothalamic-pituitary-adrenal axis in obesity.
Endocrinology 2003;144(7):2997-3003.
2003: Robert S Lindsay; Deborah J Wake; Saraswathy Nair; Joy C Bunt; Dawn E W Livingstone; Paska A Permana; P Antonio Tataranni; Brian R Walker
Subcutaneous adipose 11 beta-hydroxysteroid dehydrogenase type 1 activity and messenger ribonucleic acid levels are associated with adiposity and insulinemia in Pima Indians and Caucasians.
The Journal of clinical endocrinology and metabolism 2003;88(6):2738-44.
2003: Rebecca M Reynolds; Holly E Syddall; Brian R Walker; Peter J Wood; David I W Phillips
Predicting cardiovascular risk factors from plasma cortisol measured during oral glucose tolerance tests.
Metabolism: clinical and experimental 2003;52(5):524-7.
2003: Dawn E W Livingstone; Brian R Walker
Is 11beta-hydroxysteroid dehydrogenase type 1 a therapeutic target? Effects of carbenoxolone in lean and obese Zucker rats.
The Journal of pharmacology and experimental therapeutics 2003;305(1):167-72.
2003: Mark E Cleasby; Paul A T Kelly; Brian R Walker; Jonathan R Seckl
Programming of rat muscle and fat metabolism by in utero overexposure to glucocorticoids.
Endocrinology 2003;144(3):999-1007.
2003: Brian R Walker
Mineralocorticoid mechanisms.
Hormone research 2003;59 Suppl 1():55.
2003: Rebecca M Reynolds; Brian R Walker
Human insulin resistance: the role of glucocorticoids.
Diabetes, obesity & metabolism 2003;5(1):5-12.
2003: Mark E Cleasby; Dawn E W Livingstone; Moffat J Nyirenda; Jonathan R Seckl; Brian R Walker
Is programming of glucocorticoid receptor expression by prenatal dexamethasone in the rat secondary to metabolic derangement in adulthood?
European journal of endocrinology / European Federation of Endocrine Societies 2003;148(1):129-38.
2003: Robert C Andrews; Olav Rooyackers; Brian R Walker
Effects of the 11 beta-hydroxysteroid dehydrogenase inhibitor carbenoxolone on insulin sensitivity in men with type 2 diabetes.
The Journal of clinical endocrinology and metabolism 2003;88(1):285-91.
2002: Robert C Andrews; Olive Herlihy; Dawn E W Livingstone; Ruth Andrew; Brian R Walker
Abnormal cortisol metabolism and tissue sensitivity to cortisol in patients with glucose intolerance.
The Journal of clinical endocrinology and metabolism 2002;87(12):5587-93.
2002: Brian R Walker; R John Irving; Ruth Andrew; Neville R Belton
Contrasting effects of intrauterine growth retardation and premature delivery on adult cortisol secretion and metabolism in man.
Clinical endocrinology 2002;57(3):351-5.
2002: Eva Rask; Brian R Walker; Siv Söderberg; Dawn E W Livingstone; Mats Eliasson; Owe Johnson; Ruth Andrew; Tommy Olsson
Tissue-specific changes in peripheral cortisol metabolism in obese women: increased adipose 11beta-hydroxysteroid dehydrogenase type 1 activity.
The Journal of clinical endocrinology and metabolism 2002;87(7):3330-6.
2002: R John Irving; Maggie N Carson; David J Webb; Brian R Walker
Peripheral vascular structure and function in men with contrasting GH levels.
The Journal of clinical endocrinology and metabolism 2002;87(7):3309-14.
2002: Ruth Andrew; Kenneth Smith; Gregory C Jones; Brian R Walker
Distinguishing the activities of 11beta-hydroxysteroid dehydrogenases in vivo using isotopically labeled cortisol.
The Journal of clinical endocrinology and metabolism 2002;87(1):277-85.
2001: Patrick W F Hadoke; C Christy; Yuri Kotelevtsev; BC Williams; Christopher J Kenyon; Jonathan R Seckl; John J Mullins; Brian R Walker
Endothelial cell dysfunction in mice after transgenic knockout of type 2, but not type 1, 11beta-hydroxysteroid dehydrogenase.
Circulation 2001;104(23):2832-7.
2001: Jonathan R Seckl; Brian R Walker
Minireview: 11beta-hydroxysteroid dehydrogenase type 1- a tissue-specific amplifier of glucocorticoid action.
Endocrinology 2001;142(4):1371-6.
2001: Eva Rask; Tommy Olsson; Siv Söderberg; Ruth Andrew; Dawn E W Livingstone; Owe Johnson; Brian R Walker
Tissue-specific dysregulation of cortisol metabolism in human obesity.
The Journal of clinical endocrinology and metabolism 2001;86(3):1418-21.
2001: Rebecca M Reynolds; Brian R Walker; Holly E Syddall; Christopher B Whorwood; Peter J Wood; David I W Phillips
Elevated plasma cortisol in glucose-intolerant men: differences in responses to glucose and habituation to venepuncture.
The Journal of clinical endocrinology and metabolism 2001;86(3):1149-53.
2001: Rebecca M Reynolds; Brian R Walker; Holly E Syddall; Ruth Andrew; Peter J Wood; Christopher B Whorwood; David I W Phillips
Altered control of cortisol secretion in adult men with low birth weight and cardiovascular risk factors.
The Journal of clinical endocrinology and metabolism 2001;86(1):245-50.
2000: D E Livingstone; Christopher J Kenyon; Brian R Walker
Mechanisms of dysregulation of 11 beta-hydroxysteroid dehydrogenase type 1 in obese Zucker rats.
The Journal of endocrinology 2000;167(3):533-9.
2000: Ruth Andrew; David I W Phillips; Brian R Walker
Influence of gender and body composition on glucocorticoid metabolism in middle-aged humans.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 2000;24 Suppl 2():S144-5.
2000: David I W Phillips; Brian R Walker; Rebecca M Reynolds; DE Flanagan; Peter J Wood; Clive Osmond; D J Barker; Christopher B Whorwood
Low birth weight predicts elevated plasma cortisol concentrations in adults from 3 populations.
Hypertension 2000;35(6):1301-6.
2000: PM Jamieson; Brian R Walker; Karen E Chapman; Ruth Andrew; S Rossiter; Jonathan R Seckl
11 beta-hydroxysteroid dehydrogenase type 1 is a predominant 11 beta-reductase in the intact perfused rat liver.
The Journal of endocrinology 2000;165(3):685-92.
2000: Brian R Walker
How will we know if 11beta-hydroxysteroid dehydrogenases are important in common diseases.
Clinical endocrinology 2000;52(4):401-2.
2000: D E Livingstone; G C Jones; K Smith; PM Jamieson; Ruth Andrew; Christopher J Kenyon; Brian R Walker
Understanding the role of glucocorticoids in obesity: tissue-specific alterations of corticosterone metabolism in obese Zucker rats.
Endocrinology 2000;141(2):560-3.
2000: Brian R Walker; Andrew Rodin; N F Taylor; R N Clayton
Endogenous inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 do not explain abnormal cortisol metabolism in polycystic ovary syndrome.
Clinical endocrinology 2000;52(1):77-80.
2000: Brian R Walker
Deflazacort: towards selective glucocorticoid receptor modulation?
Clinical endocrinology 2000;52(1):13-5.
1999: M J Finken; Robert C Andrews; Ruth Andrew; Brian R Walker
Cortisol metabolism in healthy young adults: sexual dimorphism in activities of A-ring reductases, but not 11beta-hydroxysteroid dehydrogenases.
The Journal of clinical endocrinology and metabolism 1999;84(9):3316-21.
1999: Robert C Andrews; Brian R Walker
Glucocorticoids and insulin resistance: old hormones, new targets.
Clinical science (London, England : 1979) 1999;96(5):513-23.
1999: Jonathan R Seckl; Moffat J Nyirenda; Brian R Walker; Karen E Chapman
Glucocorticoids and fetal programming.
Biochemical Society transactions 1999;27(2):74-8.
1999: PM Jamieson; Moffat J Nyirenda; Brian R Walker; Karen E Chapman; Jonathan R Seckl
Interactions between oestradiol and glucocorticoid regulatory effects on liver-specific glucocorticoid-inducible genes: possible evidence for a role of hepatic 11beta-hydroxysteroid dehydrogenase type 1.
The Journal of endocrinology 1999;160(1):103-9.
1998: Rebecca M Reynolds; HE Bendall; Christopher B Whorwood; Peter J Wood; Brian R Walker; David I W Phillips
Reproducibility of the low dose dexamethasone suppression test: comparison between direct plasma and salivary cortisol assays.
Clinical endocrinology 1998;49(3):307-10.
1998: Ruth Andrew; David I W Phillips; Brian R Walker
Obesity and gender influence cortisol secretion and metabolism in man.
The Journal of clinical endocrinology and metabolism 1998;83(5):1806-9.
1998: David I W Phillips; D J Barker; Caroline H D Fall; J R Seckl; Christopher B Whorwood; Peter J Wood; Brian R Walker
Elevated plasma cortisol concentrations: a link between low birth weight and the insulin resistance syndrome?
The Journal of clinical endocrinology and metabolism 1998;83(3):757-60.