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Neil Walker

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Marcin Lukasz Pekalski; Deborah J Smyth; Helen E Stevens; John A Todd; Timothy I M Tree; Neil M Walker; Chris Wallace; Xaquin Castro Dopico; Gillian Coleman; Richard M R Coulson; Antony J Cutler; Calliope A Dendrou; Kate Downes; David B Dunger; L Esposito; Ricardo C Ferreira; Hui Guo; Catherine Guy; Sarah Nutland; Linda S Wicker
Postthymic expansion in human CD4 naive T cells defined by expression of functional high-affinity IL-2 receptors.
Jason D Cooper; Jayne A Franklyn; Oliver J Brand; Oliver Burren; Gillian Coleman; Hui Guo; Matthew J Simmonds; Helen Stevens; John A Todd; Neil M Walker; Chris Wallace; Stephen C L Gough
Seven newly identified loci for autoimmune thyroid disease.
Nada M Saleh; Deborah J Smyth; Helen E Stevens; Louise Bell; Joanna M M Howson; Srilakshmi M Raj; Neil M Walker; chris wallace; John A Todd
Genetic association analyses of atopic illness and proinflammatory cytokine genes with type 1 diabetes.

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2013: Marcin Lukasz Pekalski; Deborah J Smyth; Helen E Stevens; John A Todd; Timothy I M Tree; Neil M Walker; Chris Wallace; Xaquin Castro Dopico; Gillian Coleman; Richard M R Coulson; Antony J Cutler; Calliope A Dendrou; Kate Downes; David B Dunger; L Esposito; Ricardo C Ferreira; Hui Guo; Catherine Guy; Sarah Nutland; Linda S Wicker
Postthymic expansion in human CD4 naive T cells defined by expression of functional high-affinity IL-2 receptors.
Journal of immunology (Baltimore, Md. : 1950) 2013;190(6):2554-66.
2012: Jason D Cooper; Jayne A Franklyn; Oliver J Brand; Oliver Burren; Gillian Coleman; Hui Guo; Matthew J Simmonds; Helen Stevens; John A Todd; Neil M Walker; Chris Wallace; Stephen C L Gough
Seven newly identified loci for autoimmune thyroid disease.
Human molecular genetics 2012;21(23):5202-8.
2011: Nada M Saleh; Deborah J Smyth; Helen E Stevens; Louise Bell; Joanna M M Howson; Srilakshmi M Raj; Neil M Walker; chris wallace; John A Todd
Genetic association analyses of atopic illness and proinflammatory cytokine genes with type 1 diabetes.
Diabetes/metabolism research and reviews 2011;27(8):838-43.
2011: Deborah J Smyth; Helen Stevens; Neil M Walker; Pamela Clarke; Jason D Cooper; Kate Downes; Joanna M M Howson; Trupti Mistry; John A Todd
FUT2 nonsecretor status links type 1 diabetes susceptibility and resistance to infection.
Diabetes 2011;60(11):3081-4.
2011: Joanna M M Howson; Deborah J Smyth; Helen Stevens; Polly J Bingley; Kyla A Chandler; Neil M Walker; John A Todd
Evidence that HLA class I and II associations with type 1 diabetes, autoantibodies to GAD and autoantibodies to IA-2, are distinct.
Diabetes 2011;60(10):2635-44.
2011: Jason D Cooper; Deborah J Smyth; Neil M Walker; Helen Stevens; Oliver S Burren; chris wallace; Christopher Greissl; Elizabeth Ramos Lopez; Elina Hyppönen; David D Dunger; Timothy D Spector; Willem H Ouwehand; Thomas J Wang; Klaus Badenhoop; John A Todd
Inherited variation in vitamin D genes is associated with predisposition to autoimmune disease type 1 diabetes.
Diabetes 2011;60(5):1624-31.
2011: Jennie H M Yang; Neil M Walker; Kate Downes; Joanna M M Howson; Sarah Nutland; Helen E Stevens; John A Todd
Evidence of association with type 1 diabetes in the SLC11A1 gene region.
BMC medical genetics 2011;12():59.
2010: Kate Downes; Marcin Lukasz Pekalski; Karen L Angus; Matthew Hardy; Sarah Nutland; Deborah J Smyth; Neil M Walker; chris wallace; John A Todd
Reduced expression of IFIH1 is protective for type 1 diabetes.
PloS one 2010;5(9):.
2010: chris wallace; Deborah J Smyth; Meeta Maisuria-Armer; Neil M Walker; John A Todd; David G Clayton
The imprinted DLK1-MEG3 gene region on chromosome 14q32.2 alters susceptibility to type 1 diabetes.
Nature genetics 2010;42(1):68-71.
2009: Jason D Cooper; Neil M Walker; Barry C Healy; Deborah J Smyth; K Downes; John A Todd
Analysis of 55 autoimmune disease and type II diabetes loci: further confirmation of chromosomes 4q27, 12q13.2 and 12q24.13 as type I diabetes loci, and support for a new locus, 12q13.3-q14.1.
Genes and immunity 2009;10 Suppl 1():S95-120.
2009: Jason D Cooper; Neil M Walker; Deborah J Smyth; K Downes; Barry C Healy; John A Todd
Follow-up of 1715 SNPs from the Wellcome Trust Case Control Consortium genome-wide association study in type I diabetes families.
Genes and immunity 2009;10 Suppl 1():S85-94.
2009: Joanna M M Howson; Neil M Walker; Deborah J Smyth; John A Todd
Analysis of 19 genes for association with type I diabetes in the Type I Diabetes Genetics Consortium families.
Genes and immunity 2009;10 Suppl 1():S74-84.
2009: S M Raj; Joanna M M Howson; Neil M Walker; Jason D Cooper; Deborah J Smyth; S F Field; Helen E Stevens; John A Todd
No association of multiple type 2 diabetes loci with type 1 diabetes.
Diabetologia 2009;52(10):2109-16.
2009: Jeffrey C Barrett; David G Clayton; Patrick Concannon; Beena Akolkar; Jason D Cooper; Henry A Erlich; Cécile Julier; Grant Morahan; Jørn Nerup; Concepcion Nierras; Vincent Plagnol; Flemming Pociot; Helen Schuilenburg; Deborah J Smyth; Helen Stevens; John A Todd; Neil M Walker; Stephen S Rich
Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes.
Nature genetics 2009;41(6):703-7.
2009: E Y M G Fung; Deborah J Smyth; Joanna M M Howson; Jason D Cooper; Neil M Walker; Helen Stevens; Linda S Wicker; John A Todd
Analysis of 17 autoimmune disease-associated variants in type 1 diabetes identifies 6q23/TNFAIP3 as a susceptibility locus.
Genes and immunity 2009;10(2):188-91.
2009: Joanna M M Howson; Neil M Walker; David Clayton; John A Todd
Confirmation of HLA class II independent type 1 diabetes associations in the major histocompatibility complex including HLA-B and HLA-A.
Diabetes, obesity & metabolism 2009;11 Suppl 1():31-45.
2009: J P Hafler; Lisa M Maier; Jason D Cooper; Vincent Plagnol; A Hinks; M J Simmonds; Helen E Stevens; Neil M Walker; Barry Healy; Joanna M M Howson; M Maisuria; S Duley; G Coleman; S C L Gough; J Worthington; V K Kuchroo; Linda S Wicker; John A Todd
CD226 Gly307Ser association with multiple autoimmune diseases.
Genes and immunity 2009;10(1):5-10.
2008: Deborah J Smyth; Vincent Plagnol; Neil M Walker; Jason D Cooper; Kate Downes; Jennie H M Yang; Joanna M M Howson; Helen Stevens; Ross McManus; Cisca Wijmenga; Graham A Heap; Patrick C Dubois; David G Clayton; Karen A Hunt; David A van Heel; John A Todd
Shared and distinct genetic variants in type 1 diabetes and celiac disease.
The New England journal of medicine 2008;359(26):2767-77.
2008: Jason D Cooper; Deborah J Smyth; Adam M Smiles; Vincent Plagnol; Neil M Walker; James E Allen; Kate Downes; Jeffrey C Barrett; Barry C Healy; Josyf C Mychaleckyj; James H Warram; John A Todd
Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci.
Nature genetics 2008;40(12):1399-401.
2008: Sarah F Field; Sergey Nejentsev; Neil M Walker; Joanna M M Howson; Lisa M Taylor; Jennifer D Jolley; Matthew P A Hardy; John A Todd
Sequencing-based genotyping and association analysis of the MICA and MICB genes in type 1 diabetes.
Diabetes 2008;57(6):1753-6.
2008: Deborah J Smyth; Jason D Cooper; Joanna M M Howson; Neil M Walker; Vincent Plagnol; Helen Stevens; David G Clayton; John A Todd
PTPN22 Trp620 explains the association of chromosome 1p13 with type 1 diabetes and shows a statistical interaction with HLA class II genotypes.
Diabetes 2008;57(6):1730-7.
2007: Sergey Nejentsev; Joanna M M Howson; Neil M Walker; Jeffrey S Szeszko; Sarah F Field; Helen E Stevens; Pamela Reynolds; Matthew Hardy; Erna King; Jennifer Masters; John S Hulme; Lisa M Maier; Deborah Smyth; Rebecca Bailey; Jason D Cooper; Gloria Ribas; R Duncan Campbell; David G Clayton; John A Todd
Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A.
Nature 2007;450(7171):887-92.
2007: S F Field; Joanna M M Howson; Neil M Walker; David D Dunger; J A Todd
Analysis of the obesity gene FTO in 14,803 type 1 diabetes cases and controls.
Diabetologia 2007;50(10):2218-20.
2007: Rebecca Bailey; Jason D Cooper; Lauren Zeitels; Deborah J Smyth; Jennie H M Yang; Neil M Walker; Elina Hyppönen; David D Dunger; Elizabeth Ramos Lopez; Klaus Badenhoop; Sergey Nejentsev; John A Todd
Association of the vitamin D metabolism gene CYP27B1 with type 1 diabetes.
Diabetes 2007;56(10):2616-21.
2007: Christopher E Lowe; Jason D Cooper; Todd Brusko; Neil M Walker; Deborah J Smyth; Rebecca Bailey; Kirsi Bourget; Vincent Plagnol; Sarah Field; Mark Atkinson; David G Clayton; Linda S Wicker; John A Todd
Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes.
Nature genetics 2007;39(9):1074-82.
2007: Felicity Payne; Jason D Cooper; Neil M Walker; Alex C Lam; Luc J Smink; Sarah Nutland; Helen E Stevens; Jayne Hutchings; John A Todd
Interaction analysis of the CBLB and CTLA4 genes in type 1 diabetes.
Journal of leukocyte biology 2007;81(3):581-3.
2007: Jason D Cooper; Deborah J Smyth; Rebecca Bailey; Felicity Payne; Kate Downes; Lisa M Taylor; Jennifer Masters; Lauren R Zeitels; Adrian Vella; Neil M Walker; John A Todd
The candidate genes TAF5L, TCF7, PDCD1, IL6 and ICAM1 cannot be excluded from having effects in type 1 diabetes.
BMC medical genetics 2007;8():71.
2007: Sergey Nejentsev; Luc J Smink; Deborah Smyth; Rebecca Bailey; Christopher E Lowe; Felicity Payne; Jennifer Masters; Lisa M Taylor; Alex Lam; Oliver Burren; Helen Stevens; Sarah Nutland; Neil M Walker; Anne Smith; Rebecca C J Twells; Bryan J Barratt; Charmain Wright; Lisa French; Yuan Chen; Panos Deloukas; Jane Rogers; Carl Bruder; John A Todd
Sequencing and association analysis of the type 1 diabetes-linked region on chromosome 10p12-q11.
BMC genetics 2007;8():24.
2007: Erin M Hulbert; Luc J Smink; Ellen C Adlem; James E Allen; David B Burdick; Oliver Burren; Victor M Cassen; Christopher C Cavnor; Geoffrey E Dolman; Daisy Flamez; Karen F Friery; Barry C Healy; Sarah A Killcoyne; Burak Kutlu; Helen Schuilenburg; Neil M Walker; Josyf C Mychaleckyj; Decio L Eizirik; Linda S Wicker; John A Todd; Nathan Goodman
T1DBase: integration and presentation of complex data for type 1 diabetes research.
Nucleic acids research 2007;35(Database issue):D742-6.
2007: S F Field; Joanna M M Howson; Deborah J Smyth; Neil M Walker; David D Dunger; John A Todd
Analysis of the type 2 diabetes gene, TCF7L2, in 13,795 type 1 diabetes cases and control subjects.
Diabetologia 2007;50(1):212-3.
2006: Rebecca Pask; Jason D Cooper; Neil M Walker; Sarah Nutland; Jayne Hutchings; David D Dunger; Sergey Nejentsev; John A Todd
No evidence for a major effect of two common polymorphisms of the catalase gene in type 1 diabetes susceptibility.
Diabetes/metabolism research and reviews 2006;22(5):356-60.
2006: Deborah J Smyth; Jason D Cooper; Rebecca Bailey; Sarah Field; Oliver Burren; Luc J Smink; Cristian Guja; Constantin Ionescu-Tirgoviste; Barry Widmer; David D Dunger; David A Savage; Neil M Walker; David G Clayton; John A Todd
A genome-wide association study of nonsynonymous SNPs identifies a type 1 diabetes locus in the interferon-induced helicase (IFIH1) region.
Nature genetics 2006;38(6):617-9.
2006: Deborah J Smyth; Jason D Cooper; Christopher E Lowe; Sarah Nutland; Neil M Walker; David G Clayton; John A Todd
No evidence for association of OAS1 with type 1 diabetes in unaffected siblings or type 1 diabetic cases.
Diabetes 2006;55(5):1525-8.
2006: Jeffrey S Szeszko; Joanna M M Howson; Jason D Cooper; Neil M Walker; Rebecca C J Twells; Helen E Stevens; Sarah Nutland; John A Todd
Analysis of polymorphisms of the interleukin-18 gene in type 1 diabetes and Hardy-Weinberg equilibrium testing.
Diabetes 2006;55(2):559-62.
2006: Hidenori Taniguchi; Christopher E Lowe; Jason D Cooper; Deborah J Smyth; Rebecca Bailey; Sarah Nutland; Barry C Healy; Alex C Lam; Oliver Burren; Neil M Walker; Luc J Smink; Linda S Wicker; John A Todd
Discovery, linkage disequilibrium and association analyses of polymorphisms of the immune complement inhibitor, decay-accelerating factor gene (DAF/CD55) in type 1 diabetes.
BMC genetics 2006;7():22.
2006: Deborah J Smyth; Joanna M M Howson; Felicity Payne; Lisa M Maier; Rebecca Bailey; Kieran Holland; Christopher E Lowe; Jason D Cooper; John S Hulme; Adrian Vella; Ingrid Dahlman; Alex C Lam; Sarah Nutland; Neil M Walker; Rebecca C J Twells; John A Todd
Analysis of polymorphisms in 16 genes in type 1 diabetes that have been associated with other immune-mediated diseases.
BMC medical genetics 2006;7():20.
2006: Gerard A J Morris; Christopher E Lowe; Jason D Cooper; Felicity Payne; Adrian Vella; Lisa M Taylor; John S Hulme; Neil M Walker; Barry C Healy; Alex C Lam; Paul A Lyons; John A Todd
Polymorphism discovery and association analyses of the interferon genes in type 1 diabetes.
BMC genetics 2006;7():12.
2005: David G Clayton; Neil M Walker; Deborah J Smyth; Rebecca Pask; Jason D Cooper; Lisa M Maier; Luc J Smink; Alex C Lam; Nigel R Ovington; Helen E Stevens; Sarah Nutland; Joanna M M Howson; Malek Faham; Martin Moorhead; Hywel B Jones; Matthew Falkowski; Paul Hardenbol; Thomas D Willis; John A Todd
Population structure, differential bias and genomic control in a large-scale, case-control association study.
Nature genetics 2005;37(11):1243-6.
2005: Felicity Payne; Deborah J Smyth; Rebecca Pask; Jason D Cooper; Jennifer Masters; William Y S Wang; Lisa M Taylor; Georgina Bowden; Jeffrey S Szeszko; Luc J Smink; Alex C Lam; Oliver Burren; Neil M Walker; Sarah Nutland; Helen E Rance; DAG UNDLIEN; Kjersti S Rønningen; Cristian Guja; Constantin Ionescu-Tîrgovişte; John A Todd; Rebecca C J Twells
No evidence for association of the TATA-box binding protein glutamine repeat sequence or the flanking chromosome 6q27 region with type 1 diabetes.
Biochemical and biophysical research communications 2005;331(2):435-41.
2005: Deborah J Smyth; Joanna M M Howson; Christopher E Lowe; Neil M Walker; Alex C Lam; Sarah Nutland; Jayne Hutchings; Eva Tuomilehto-Wolf; Jaakko Tuomilehto; Cristian Guja; Constantin Ionescu-Tîrgoviste; DAG UNDLIEN; Kjersti S Rønningen; David Savage; David D Dunger; Rebecca C J Twells; Wendy L McArdle; David P Strachan; John A Todd
Assessing the validity of the association between the SUMO4 M55V variant and risk of type 1 diabetes.
Nature genetics 2005;37(2):110-1; author reply 112-3.
2005: Luc J Smink; Erin M Helton; Barry C Healy; Christopher C Cavnor; Alex C Lam; Daisy Flamez; Oliver Burren; Yang Wang; Geoffrey E Dolman; David B Burdick; Vincent H Everett; Gustavo Glusman; Davide Laneri; Lee Rowen; Helen Schuilenburg; Neil M Walker; Josyf C Mychaleckyj; Linda S Wicker; Decio L Eizirik; John A Todd; Nathan Goodman
T1DBase, a community web-based resource for type 1 diabetes research.
Nucleic acids research 2005;33(Database issue):D544-9.
2004: Sergey Nejentsev; Jason D Cooper; Lisa M Taylor; Joanna M M Howson; Helen E Rance; Sarah Nutland; Neil M Walker; Cristian Guja; Constantin Ionescu-Tirgovişte; David A Savage; DAG UNDLIEN; Kjersti S Rønningen; Eva Tuomilehto-Wolf; Jaakko Tuomilehto; Kathleen M Gillespie; Susan M Ring; David P Strachan; Barry Widmer; David D Dunger; John A Todd
Analysis of the vitamin D receptor gene sequence variants in type 1 diabetes.
Diabetes 2004;53(10):2709-12.
2004: Sergey Nejentsev; Lisa M Taylor; Hywel Snook; Helen E Rance; Sarah Nutland; Neil M Walker; Alex C Lam; Cristian Guja; Constantin Ionescu-Tirgoviste; DAG UNDLIEN; Kjersti S Rønningen; Eva Tuomilehto-Wolf; Jaakko Tuomilehto; Melanie J Newport; David G Clayton; John A Todd
Comparative high-resolution analysis of linkage disequilibrium and tag single nucleotide polymorphisms between populations in the vitamin D receptor gene.
Human molecular genetics 2004;13(15):1633-9.
2004: Rebecca Pask; Helen E Rance; Bryan J Barratt; Sarah Nutland; Deborah J Smyth; Meera Sebastian; Rebecca C J Twells; Anne Smith; Alex C Lam; Luc J Smink; Neil M Walker; John A Todd
Investigating the utility of combining phi29 whole genome amplification and highly multiplexed single nucleotide polymorphism BeadArray genotyping.
BMC biotechnology 2004;4():15.
2004: Christina Eftychi; Joanna M M Howson; Bryan J Barratt; Adrian Vella; Felicity Payne; Deborah J Smyth; Rebecca C J Twells; Neil M Walker; Helen E Rance; Eva Tuomilehto-Wolf; Jaakko Tuomilehto; DAG UNDLIEN; Kjersti S Rønningen; Cristian Guja; Constantin Ionescu-Tîirgovişte; David A Savage; John A Todd
Analysis of the type 2 diabetes-associated single nucleotide polymorphisms in the genes IRS1, KCNJ11, and PPARG2 in type 1 diabetes.
Diabetes 2004;53(3):870-3.
2004: Felicity Payne; Deborah J Smyth; Rebecca Pask; Bryan J Barratt; Jason D Cooper; Rebecca C J Twells; Neil M Walker; Alex C Lam; Luc J Smink; Sarah Nutland; Helen E Rance; John A Todd
Haplotype tag single nucleotide polymorphism analysis of the human orthologues of the rat type 1 diabetes genes Ian4 (Lyp/Iddm1) and Cblb.
Diabetes 2004;53(2):505-9.
2004: Oliver Burren; Barry C Healy; Alex C Lam; Helen Schuilenburg; Geoffrey E Dolman; Vincent H Everett; Davide Laneri; Sarah Nutland; Helen E Rance; Felicity Payne; Deborah Smyth; Chris Lowe; Bryan J Barratt; Rebecca C J Twells; Dan Rainbow; Linda S Wicker; John A Todd; Neil M Walker; Luc J Smink
Development of an integrated genome informatics, data management and workflow infrastructure: a toolbox for the study of complex disease genetics.
Human genomics 2004;1(2):98-109.
2003: Lisa M Maier; Rebecca C J Twells; Joanna M M Howson; Alex C Lam; David G Clayton; Deborah J Smyth; David Savage; D Carson; Chris C Patterson; Luc J Smink; Neil M Walker; Oliver Burren; Sarah Nutland; Helen E Rance; Eva Tuomilehto-Wolf; Jaakko Tuomilehto; Cristian Guja; Constantin Ionescu-Tirgoviste; DAG UNDLIEN; Kjersti S Rønningen; Francesco Cucca; John A Todd
Testing the possible negative association of type 1 diabetes and atopic disease by analysis of the interleukin 4 receptor gene.
Genes and immunity 2003;4(7):469-75.
2002: Hilary A Ashton; Martin Buxton; Nicholas E Day; Lois G Kim; Theresa M Marteau; R A P Scott; Simon G Thompson; Neil M Walker
The Multicentre Aneurysm Screening Study (MASS) into the effect of abdominal aortic aneurysm screening on mortality in men: a randomised controlled trial.
Lancet 2002;360(9345):1531-9.
2002: Katerina A Vardulaki; Neil M Walker; E Couto; Nicholas E Day; Simon G Thompson; Hilary A Ashton; R A P Scott
Late results concerning feasibility and compliance from a randomized trial of ultrasonographic screening for abdominal aortic aneurysm.
The British journal of surgery 2002;89(7):861-4.
2002: E Couto; Stephen W Duffy; Hilary A Ashton; Neil M Walker; J P Myles; R A P Scott; Simon G Thompson
Probabilities of progression of aortic aneurysms: estimates and implications for screening policy.
Journal of medical screening 2002;9(1):40-2.
2001: R A P Scott; Katerina A Vardulaki; Neil M Walker; Nicholas E Day; Stephen W Duffy; Hilary A Ashton
The long-term benefits of a single scan for abdominal aortic aneurysm (AAA) at age 65.
European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery 2001;21(6):535-40.
2000: Katerina A Vardulaki; Neil M Walker; Nicholas E Day; Stephen W Duffy; Hilary A Ashton; R A P Scott
Quantifying the risks of hypertension, age, sex and smoking in patients with abdominal aortic aneurysm.
The British journal of surgery 2000;87(2):195-200.
1999: Katerina A Vardulaki; T C Prevost; Neil M Walker; Nicholas E Day; A B M Wilmink; C R G Quick; Hilary A Ashton; R A P Scott
Incidence among men of asymptomatic abdominal aortic aneurysms: estimates from 500 screen detected cases.
Journal of medical screening 1999;6(1):50-4.
1998: Katerina A Vardulaki; T C Prevost; Neil M Walker; Nicholas E Day; A B M Wilmink; C R G Quick; Hilary A Ashton; R A P Scott
Growth rates and risk of rupture of abdominal aortic aneurysms.
The British journal of surgery 1998;85(12):1674-80.