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John Wallace

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John L Wallace
Mechanisms, prevention and clinical implications of nonsteroidal anti-inflammatory drug-enteropathy.
John L Wallace; Jose G P Ferraz; Marcelo N Muscara
Hydrogen sulfide: an endogenous mediator of resolution of inflammation and injury.
John L Wallace
Hydrogen sulfide: a rescue molecule for mucosal defence and repair.

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All Publications

2013: John L Wallace
Mechanisms, prevention and clinical implications of nonsteroidal anti-inflammatory drug-enteropathy.
World journal of gastroenterology : WJG 2013;19(12):1861-76.
2012: John L Wallace; Jose G P Ferraz; Marcelo N Muscara
Hydrogen sulfide: an endogenous mediator of resolution of inflammation and injury.
Antioxidants & redox signaling 2012;17(1):58-67.
2012: John L Wallace
Hydrogen sulfide: a rescue molecule for mucosal defence and repair.
Digestive diseases and sciences 2012;57(6):1432-4.
2012: Neil Dufton; Jane Natividad; Elena F Verdu; John L Wallace
Hydrogen sulfide and resolution of acute inflammation: A comparative study utilizing a novel fluorescent probe.
Scientific reports 2012;2():499.
2010: Gary R Martin; G Webb McKnight; Michael S Dicay; Carla S Coffin; Jose G P Ferraz; John L Wallace
Hydrogen sulphide synthesis in the rat and mouse gastrointestinal tract.
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 2010;42(2):103-9.
2009: John L Wallace; Linda Vong; Webb McKnight; Michael Dicay; Gary R Martin
Endogenous and exogenous hydrogen sulfide promotes resolution of colitis in rats.
Gastroenterology 2009;137(2):569-78, 578.e1.
2009: Derek M McKay; John L Wallace
Acetic acid induced ulceration in rats is not affected by infection with Hymenolepis diminuta.
The Journal of parasitology 2009;95(2):481-2.
2008: John L Wallace; Linda Vong
NSAID-induced gastrointestinal damage and the design of GI-sparing NSAIDs.
Current opinion in investigational drugs (London, England : 2000) 2008;9(11):1151-6.
2008: A E Chávez-Piña; L Vong; Webb McKnight; Michael Dicay; Renata C O Zanardo; M I Ortiz; G Castañeda-Hernández; John L Wallace
Lack of effects of acemetacin on signalling pathways for leukocyte adherence may explain its gastrointestinal safety.
British journal of pharmacology 2008;155(6):857-64.
2008: Gary R Martin; Mauro Perretti; Roderick J Flower; John L Wallace
Annexin-1 modulates repair of gastric mucosal injury.
American journal of physiology. Gastrointestinal and liver physiology 2008;294(3):G764-9.
2007: John L Wallace; Michael Dicay; Webb McKnight; Gary R Martin
Hydrogen sulfide enhances ulcer healing in rats.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2007;21(14):4070-6.
2007: A E Chávez-Piña; Webb McKnight; Michael Dicay; G Castañeda-Hernández; John L Wallace
Mechanisms underlying the anti-inflammatory activity and gastric safety of acemetacin.
British journal of pharmacology 2007;152(6):930-8.
2007: John L Wallace
Hydrogen sulfide-releasing anti-inflammatory drugs.
Trends in pharmacological sciences 2007;28(10):501-5.
2007: John L Wallace
Building a better aspirin: gaseous solutions to a century-old problem.
British journal of pharmacology 2007;152(4):421-8.
2007: Stefano Fiorucci; Stefano Orlandi; Andrea Mencarelli; Giuseppe Caliendo; Vincenzo Santagada; Eleonora Distrutti; Luca Santucci; Giuseppe Cirino; John L Wallace
Enhanced activity of a hydrogen sulphide-releasing derivative of mesalamine (ATB-429) in a mouse model of colitis.
British journal of pharmacology 2007;150(8):996-1002.
2007: Vanessa Moreira; Stella R Zamuner; John L Wallace; Catarina de Fátima Pereira Teixeira
Bothrops jararaca and Crotalus durissus terrificus venoms elicit distinct responses regarding to production of prostaglandins E2 and D2, and expression of cyclooxygenases.
Toxicon : official journal of the International Society on Toxinology 2007;49(5):615-24.
2007: Renata do A Olivo; Catarina F P Teixeira; John L Wallace; Jose M Gutierrez; Stella R Zamuner
Role of cyclooxygenases in oedema-forming activity of bothropic venoms.
Toxicon : official journal of the International Society on Toxinology 2007;49(5):670-7.
2007: John L Wallace; Giuseppe Caliendo; Vincenzo Santagada; Giuseppe Cirino; Stefano Fiorucci
Gastrointestinal safety and anti-inflammatory effects of a hydrogen sulfide-releasing diclofenac derivative in the rat.
Gastroenterology 2007;132(1):261-71.
2006: Andrew C Skinn; Nathalie Vergnolle; Stella R Zamuner; John L Wallace; Laurie Cellars; Wallace K MacNaughton; Philip M Sherman
Citrobacter rodentium infection causes iNOS-independent intestinal epithelial dysfunction in mice.
Canadian journal of physiology and pharmacology 2006;84(12):1301-12.
2006: Renata C O Zanardo; Vincenzo Brancaleone; Eleonora Distrutti; Stefano Fiorucci; Giuseppe Cirino; John L Wallace
Hydrogen sulfide is an endogenous modulator of leukocyte-mediated inflammation.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(12):2118-20.
2006: Eleonora Distrutti; Luca Sediari; Andrea Mencarelli; Barbara Renga; Stefano Orlandi; Giuseppe Russo; Giuseppe Caliendo; Vincenzo Santagada; Giuseppe Cirino; John L Wallace; Stefano Fiorucci
5-Amino-2-hydroxybenzoic acid 4-(5-thioxo-5H-[1,2]dithiol-3yl)-phenyl ester (ATB-429), a hydrogen sulfide-releasing derivative of mesalamine, exerts antinociceptive effects in a model of postinflammatory hypersensitivity.
The Journal of pharmacology and experimental therapeutics 2006;319(1):447-58.
2006: Nathalie Vergnolle; Laurie Cellars; Andrea Mencarelli; Giovanni Rizzo; Sunita Swaminathan; Paul Beck; Martin Steinhoff; Patricia Andrade-Gordon; Nigel W Bunnett; Morley D Hollenberg; John L Wallace; Giuseppe Cirino; Stefano Fiorucci
A role for proteinase-activated receptor-1 in inflammatory bowel diseases.
The Journal of clinical investigation 2006;116(7):2056.
2006: Stefano Fiorucci; Eleonora Distrutti; Giuseppe Cirino; John L Wallace
The emerging roles of hydrogen sulfide in the gastrointestinal tract and liver.
Gastroenterology 2006;131(1):259-71.
2006: John L Wallace; Michael Dicay; Webb McKnight; Genevieve K Dudar
Platelets accelerate gastric ulcer healing through presentation of vascular endothelial growth factor.
British journal of pharmacology 2006;148(3):274-8.
2006: John L Wallace
Nitric oxide, aspirin-triggered lipoxins and NO-aspirin in gastric protection.
Inflammation & allergy drug targets 2006;5(2):133-7.
2006: Marcelo N Muscará; John L Wallace
COX-inhibiting nitric oxide donors (CINODs): potential benefits on cardiovascular and renal function.
Cardiovascular & hematological agents in medicinal chemistry 2006;4(2):155-64.
2006: John L Wallace
Commonality of defensive roles of COX-2 in the lung and gut.
The American journal of pathology 2006;168(4):1060-3.
2006: Gary R Martin; John L Wallace
Gastrointestinal inflammation: a central component of mucosal defense and repair.
Experimental biology and medicine (Maywood, N.J.) 2006;231(2):130-7.
2006: John L Wallace
COX-2: a pivotal enzyme in mucosal protection and resolution of inflammation.
TheScientificWorldJournal 2006;6():577-88.
2006: Eleonora Distrutti; Luca Sediari; Andrea Mencarelli; Barbara Renga; Stefano Orlandi; Elisabetta Antonelli; Fiorenza Roviezzo; Antonio Morelli; Giuseppe Cirino; John L Wallace; Stefano Fiorucci
Evidence that hydrogen sulfide exerts antinociceptive effects in the gastrointestinal tract by activating KATP channels.
The Journal of pharmacology and experimental therapeutics 2006;316(1):325-35.
2005: John L Wallace
Recent advances in gastric ulcer therapeutics.
Current opinion in pharmacology 2005;5(6):573-7.
2005: Stella R Zamuner; Adrian W Bak; Pallavi R Devchand; John L Wallace
Predisposition to colorectal cancer in rats with resolved colitis: role of cyclooxygenase-2-derived prostaglandin d2.
The American journal of pathology 2005;167(5):1293-300.
2005: Stefano Fiorucci; Elisabetta Antonelli; Eleonora Distrutti; Giovanni Rizzo; Andrea Mencarelli; Stefano Orlandi; Renata C O Zanardo; Barbara Renga; Moses Di Sante; Antonio Morelli; Giuseppe Cirino; John L Wallace
Inhibition of hydrogen sulfide generation contributes to gastric injury caused by anti-inflammatory nonsteroidal drugs.
Gastroenterology 2005;129(4):1210-24.
2005: Rafael Perini; John L Wallace; Li Ma
Roles of platelets and proteinase-activated receptors in gastric ulcer healing.
Digestive diseases and sciences 2005;50 Suppl 1():S12-5.
2005: Camila L Santos; M H L P Souza; Antoniella S Gomes; Henrique P Lemos; Armenio A Santos; Fernando Q Cunha; John L Wallace
Sildenafil prevents indomethacin-induced gastropathy in rats: role of leukocyte adherence and gastric blood flow.
British journal of pharmacology 2005;146(4):481-6.
2005: Nicolas Cenac; Laurie Cellars; Martin Steinhoff; Patricia Andrade-Gordon; Morley D Hollenberg; John L Wallace; Stefano Fiorucci; Nathalie Vergnolle
Proteinase-activated receptor-1 is an anti-inflammatory signal for colitis mediated by a type 2 immune response.
Inflammatory bowel diseases 2005;11(9):792-8.
2005: John L Wallace; Octavio Menezes de Lima; Stefano Fiorucci
Lipoxins in gastric mucosal health and disease.
Prostaglandins, leukotrienes, and essential fatty acids 2005;73(3-4):251-5.
2005: Kristina K Hansen; Philip M Sherman; Laurie Cellars; Patricia Andrade-Gordon; Zhengying Pan; Amos Baruch; John L Wallace; Morley D Hollenberg; Nathalie Vergnolle
A major role for proteolytic activity and proteinase-activated receptor-2 in the pathogenesis of infectious colitis.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(23):8363-8.
2005: John L Wallace; Pallavi R Devchand
Emerging roles for cyclooxygenase-2 in gastrointestinal mucosal defense.
British journal of pharmacology 2005;145(3):275-82.
2005: May M Chou; Nathalie Vergnolle; Jason J McDougall; John L Wallace; Stephanie Marty; Val Teskey; Andre G Buret
Effects of chondroitin and glucosamine sulfate in a dietary bar formulation on inflammation, interleukin-1beta, matrix metalloprotease-9, and cartilage damage in arthritis.
Experimental biology and medicine (Maywood, N.J.) 2005;230(4):255-62.
2005: John L Wallace
Nitric oxide as a regulator of inflammatory processes.
Memórias do Instituto Oswaldo Cruz 2005;100 Suppl 1():5-9.
2005: Renata C O Zanardo; Mauro Perretti; John L Wallace
Annexin-1 is an endogenous gastroprotective factor against indomethacin-induced damage.
American journal of physiology. Gastrointestinal and liver physiology 2005;288(3):G481-6.
2005: Li Ma; Rafael Perini; Webb McKnight; Michael Dicay; André Klein; Morley D Hollenberg; John L Wallace
Proteinase-activated receptors 1 and 4 counter-regulate endostatin and VEGF release from human platelets.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(1):216-20.
2004: Stefano Fiorucci; John L Wallace; Andrea Mencarelli; Eleonora Distrutti; Giovanni Rizzo; Silvana Farneti; Antonio Morelli; Jih-Lie Tseng; Babu Suramanyam; William J Guilford; John Parkinson
A beta-oxidation-resistant lipoxin A4 analog treats hapten-induced colitis by attenuating inflammation and immune dysfunction.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(44):15736-41.
2004: Nathalie Vergnolle; Laurie Cellars; Andrea Mencarelli; Giovanni Rizzo; Sunita Swaminathan; Paul Beck; Martin Steinhoff; Patricia Andrade-Gordon; Nigel W Bunnett; Morley D Hollenberg; John L Wallace; Giuseppe Cirino; Stefano Fiorucci
A role for proteinase-activated receptor-1 in inflammatory bowel diseases.
The Journal of clinical investigation 2004;114(10):1444-56.
2004: Eric Hyun; Manlio Bolla; Martin Steinhoff; John L Wallace; Piero Del Soldato; Nathalie Vergnolle
Anti-inflammatory effects of nitric oxide-releasing hydrocortisone NCX 1022, in a murine model of contact dermatitis.
British journal of pharmacology 2004;143(5):618-25.
2004: JOSEPH ANTONY; Guido Van Marle; Wycliffe O Opii; D Allan Butterfield; francois mallet; V Wee Yong; John L Wallace; Robert M Deacon; Kenneth Warren; Christopher Power
Human endogenous retrovirus glycoprotein-mediated induction of redox reactants causes oligodendrocyte death and demyelination.
Nature neuroscience 2004;7(10):1088-95.
2004: Pierre-Yves von der Weid; Morley D Hollenberg; Stefano Fiorucci; John L Wallace
Aspirin-triggered, cyclooxygenase-2-dependent lipoxin synthesis modulates vascular tone.
Circulation 2004;110(10):1320-5.
2004: John L Wallace
Acetaminophen hepatotoxicity: NO to the rescue.
British journal of pharmacology 2004;143(1):1-2.
2004: John L Wallace; Gianni Rizzo; Giuseppe Cirino; Piero Del Soldato; Stefano Fiorucci
Enhanced anti-inflammatory potency of a nitric oxide-releasing derivative of flunisolide: role of nuclear factor-kappaB.
The Journal of pharmacology and experimental therapeutics 2004;310(3):1096-102.
2004: Hashem N Alshurafa; Grant R Stenton; John L Wallace; Morley D Hollenberg; A Dean Befus; Harissios Vliagoftis
A protease activated receptor-2 (PAR-2) activating peptide, tc-LIGRLO-NH2, induces protease release from mast cells: role in TNF degradation.
BMC pharmacology 2004;4():12.
2004: Stefano Fiorucci; Eleonora Distrutti; Andrea Mencarelli; Giovanni Rizzo; Anna Rita Di Lorenzo; Monia Baldoni; Piero Del Soldato; Antonio Morelli; John L Wallace
Cooperation between aspirin-triggered lipoxin and nitric oxide (NO) mediates antiadhesive properties of 2-(Acetyloxy)benzoic acid 3-(nitrooxymethyl)phenyl ester (NCX-4016) (NO-aspirin) on neutrophil-endothelial cell adherence.
The Journal of pharmacology and experimental therapeutics 2004;309(3):1174-82.
2004: John L Wallace; Marcelo N Muscará; Gilberto De Nucci; Stella R Zamuner; Giuseppe Cirino; Piero Del Soldato; Ennio Ongini
Gastric tolerability and prolonged prostaglandin inhibition in the brain with a nitric oxide-releasing flurbiprofen derivative, NCX-2216 [3-[4-(2-fluoro-alpha-methyl-[1,1'-biphenyl]-4-acetyloxy)-3-methoxyphenyl]-2-propenoic acid 4-nitrooxy butyl ester].
The Journal of pharmacology and experimental therapeutics 2004;309(2):626-33.
2004: Rafael Perini; Stefano Fiorucci; John L Wallace
Mechanisms of nonsteroidal anti-inflammatory drug-induced gastrointestinal injury and repair: a window of opportunity for cyclooxygenase-inhibiting nitric oxide donors.
Canadian journal of gastroenterology = Journal canadien de gastroenterologie 2004;18(4):229-36.
2004: John L Wallace; Stella R Zamuner; Webb McKnight; Michael Dicay; Andrea Mencarelli; Piero Del Soldato; Stefano Fiorucci
Aspirin, but not NO-releasing aspirin (NCX-4016), interacts with selective COX-2 inhibitors to aggravate gastric damage and inflammation.
American journal of physiology. Gastrointestinal and liver physiology 2004;286(1):G76-81.
2003: Stella R Zamuner; N Warrier; Andre G Buret; Wallace K MacNaughton; John L Wallace
Cyclooxygenase 2 mediates post-inflammatory colonic secretory and barrier dysfunction.
Gut 2003;52(12):1714-20.
2003: Alex C Chin; Nathalie Vergnolle; Wallace K MacNaughton; John L Wallace; Morley D Hollenberg; Andre G Buret
Proteinase-activated receptor 1 activation induces epithelial apoptosis and increases intestinal permeability.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(19):11104-9.
2003: Stefano Fiorucci; Luca Santucci; John L Wallace; Marco Sardina; Mario Romano; Piero Del Soldato; Antonio Morelli
Interaction of a selective cyclooxygenase-2 inhibitor with aspirin and NO-releasing aspirin in the human gastric mucosa.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(19):10937-41.
2003: Cathy Nguyen; Anne-Marie Coelho; Eileen F Grady; Steven J Compton; John L Wallace; Morley D Hollenberg; Nicolas Cenac; Rafael Garcia-Villar; Lionel Bueno; Martin Steinhoff; Nigel W Bunnett; Nathalie Vergnolle
Colitis induced by proteinase-activated receptor-2 agonists is mediated by a neurogenic mechanism.
Canadian journal of physiology and pharmacology 2003;81(9):920-7.
2003: Stefano Fiorucci; Eleonora Distrutti; Andrea Mencarelli; Antonio Morelli; Stefan A Laufor; Giuseppe Cirino; John L Wallace
Evidence that 5-lipoxygenase and acetylated cyclooxygenase 2-derived eicosanoids regulate leukocyte-endothelial adherence in response to aspirin.
British journal of pharmacology 2003;139(7):1351-9.
2003: John L Wallace; Stefano Fiorucci
A magic bullet for mucosal protection...and aspirin is the trigger!
Trends in pharmacological sciences 2003;24(7):323-6.
2003: Fusun Turesin; Piero Del Soldato; John L Wallace
Enhanced anti-inflammatory potency of a nitric oxide-releasing prednisolone derivative in the rat.
British journal of pharmacology 2003;139(5):966-72.
2003: M H L P Souza; Octavio Menezes de Lima; Stella R Zamuner; Stefano Fiorucci; John L Wallace
Gastritis increases resistance to aspirin-induced mucosal injury via COX-2-mediated lipoxin synthesis.
American journal of physiology. Gastrointestinal and liver physiology 2003;285(1):G54-61.
2003: Stefano Fiorucci; Eleonora Distrutti; Octavio Menezes de Lima; Mario Romano; Andrea Mencarelli; Miriam Barbanti; Ernesto Palazzini; Antonio Morelli; John L Wallace
Relative contribution of acetylated cyclo-oxygenase (COX)-2 and 5-lipooxygenase (LOX) in regulating gastric mucosal integrity and adaptation to aspirin.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(9):1171-3.
2003: John L Wallace
Nitric oxide-releasing mesalamine: potential utility for treatment of inflammatory bowel disease.
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 2003;35 Suppl 2():S35-40.
2003: Alan B R Thomson; S Appleman; Monika Keelan; John L Wallace
Role of gastric mucosal and gastric juice cytokine concentrations in development of bisphosphonate damage to gastric mucosa.
Digestive diseases and sciences 2003;48(2):308-14.
2003: John L Wallace; Piero Del Soldato
The therapeutic potential of NO-NSAIDs.
Fundamental & clinical pharmacology 2003;17(1):11-20.
2003: Rafael F Perini; Li Ma; John L Wallace
Mucosal repair and COX-2 inhibition.
Current pharmaceutical design 2003;9(27):2207-11.
2002: Nicolas Cenac; Anne-Marie Coelho; Cathy Nguyen; Steven Compton; Patricia Andrade-Gordon; Wallace K MacNaughton; John L Wallace; Morley D Hollenberg; Nigel W Bunnett; Rafael Garcia-Villar; Lionel Bueno; Nathalie Vergnolle
Induction of intestinal inflammation in mouse by activation of proteinase-activated receptor-2.
The American journal of pathology 2002;161(5):1903-15.
2002: Stefano Fiorucci; Octavio Menezes de Lima; Andrea Mencarelli; Barbara Palazzetti; Eleonora Distrutti; Webb McKnight; Michael Dicay; Li Ma; Mario Romano; Antonio Morelli; John L Wallace
Cyclooxygenase-2-derived lipoxin A4 increases gastric resistance to aspirin-induced damage.
Gastroenterology 2002;123(5):1598-606.
2002: Li Ma; Piero Del Soldato; John L Wallace
Divergent effects of new cyclooxygenase inhibitors on gastric ulcer healing: Shifting the angiogenic balance.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(20):13243-7.
2002: Grant R Stenton; Osamu Nohara; René E Déry; Harissios Vliagoftis; Mark Gilchrist; Ankur Johri; John L Wallace; Morley D Hollenberg; Redwan Moqbel; A Dean Befus
Proteinase-activated receptor (PAR)-1 and -2 agonists induce mediator release from mast cells by pathways distinct from PAR-1 and PAR-2.
The Journal of pharmacology and experimental therapeutics 2002;302(2):466-74.
2002: John L Wallace; Louis J Ignarro; Stefano Fiorucci
Potential cardioprotective actions of no-releasing aspirin.
Nature reviews. Drug discovery 2002;1(5):375-82.
2002: Mark Gilchrist; Michelle Savoie; Osamu Nohara; Fiona L Wills; John L Wallace; A Dean Befus
Nitric oxide synthase and nitric oxide production in in vivo-derived mast cells.
Journal of leukocyte biology 2002;71(4):618-24.
2002: Giuseppe Rossoni; Marcelo N Muscara; Giuseppe Cirino; John L Wallace
Inhibition of cyclo-oxygenase-2 exacerbates ischaemia-induced acute myocardial dysfunction in the rabbit.
British journal of pharmacology 2002;135(6):1540-6.
2002: Stefano Fiorucci; Elisabetta Antonelli; Andrea Mencarelli; Barbara Palazzetti; Lorena Alvarez-Miller; Marcelo N Muscara; Piero Del Soldato; Laura Sanpaolo; John L Wallace; Antonio Morelli
A NO-releasing derivative of acetaminophen spares the liver by acting at several checkpoints in the Fas pathway.
British journal of pharmacology 2002;135(3):589-99.
2001: John L Wallace; Marcelo N Muscará
Selective cyclo-oxygenase-2 inhibitors: cardiovascular and gastrointestinal toxicity.
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 2001;33 Suppl 2():S21-8.
2001: John L Wallace; L Ma
Inflammatory mediators in gastrointestinal defense and injury.
Experimental biology and medicine (Maywood, N.J.) 2001;226(11):1003-15.
2001: Stefano Fiorucci; Andrea Mencarelli; Barbara Palazzetti; Eleonora Distrutti; Nathalie Vergnolle; M D Hollenberg; John L Wallace; Antonio Morelli; Giuseppe Cirino
Proteinase-activated receptor 2 is an anti-inflammatory signal for colonic lamina propria lymphocytes in a mouse model of colitis.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(24):13936-41.
2001: Li Ma; Morley D Hollenberg; John L Wallace
Thrombin-induced platelet endostatin release is blocked by a proteinase activated receptor-4 (PAR4) antagonist.
British journal of pharmacology 2001;134(4):701-4.
2001: John L Wallace
Pathogenesis of NSAID-induced gastroduodenal mucosal injury.
Best practice & research. Clinical gastroenterology 2001;15(5):691-703.
2001: Stefano Fiorucci; Eleonora Distrutti; M N Ajuebor; Andrea Mencarelli; Roberta Mannucci; Barbara Palazzetti; Piero Del Soldato; Antonio Morelli; John L Wallace
NO-mesalamine protects colonic epithelial cells against apoptotic damage induced by proinflammatory cytokines.
American journal of physiology. Gastrointestinal and liver physiology 2001;281(3):G654-65.
2001: Samuel Asfaha; Wallace K MacNaughton; CB Appleyard; Kris Chadee; John L Wallace
Persistent epithelial dysfunction and bacterial translocation after resolution of intestinal inflammation.
American journal of physiology. Gastrointestinal and liver physiology 2001;281(3):G635-44.
2001: Marcelo N Muscará; Fina Lovren; Webb McKnight; Michael Dicay; Piero Del Soldato; Chris R Triggle; John L Wallace
Vasorelaxant effects of a nitric oxide-releasing aspirin derivative in normotensive and hypertensive rats.
British journal of pharmacology 2001;133(8):1314-22.
2001: Michelle C Buresi; E Schleihauf; Nathalie Vergnolle; Andre G Buret; John L Wallace; Morley D Hollenberg; Wallace K MacNaughton
Protease-activated receptor-1 stimulates Ca(2+)-dependent Cl(-) secretion in human intestinal epithelial cells.
American journal of physiology. Gastrointestinal and liver physiology 2001;281(2):G323-32.
2001: Nathalie Vergnolle; Nigel W Bunnett; Keith Sharkey; Valentine Brussee; Steven J Compton; Eileen F Grady; Giuseppe Cirino; N Gerard; A I Basbaum; Patricia Andrade-Gordon; Morley D Hollenberg; John L Wallace
Proteinase-activated receptor-2 and hyperalgesia: A novel pain pathway.
Nature medicine 2001;7(7):821-6.
2001: Li Ma; SN Elliott; Giuseppe Cirino; Andre G Buret; Louis J Ignarro; John L Wallace
Platelets modulate gastric ulcer healing: role of endostatin and vascular endothelial growth factor release.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(11):6470-5.
2001: Nathalie Vergnolle; John L Wallace; Nigel W Bunnett; Morley D Hollenberg
Protease-activated receptors in inflammation, neuronal signaling and pain.
Trends in pharmacological sciences 2001;22(3):146-52.
2001: John L Wallace
Nonsteroidal anti-inflammatory drugs and the gastrointestinal tract. Mechanisms of protection and healing: current knowledge and future research.
The American journal of medicine 2001;110(1A):19S-23S.
2001: Maureen N Ajuebor; Cory M Hogaboam; Steven Kunkel; Amanda E I Proudfoot; John L Wallace
The chemokine RANTES is a crucial mediator of the progression from acute to chronic colitis in the rat.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(1):552-8.
2000: K Barnett; C J Bell; Webb McKnight; Michael Dicay; Keith Sharkey; John L Wallace
Role of cyclooxygenase-2 in modulating gastric acid secretion in the normal and inflamed rat stomach.
American journal of physiology. Gastrointestinal and liver physiology 2000;279(6):G1292-7.
2000: Harissios Vliagoftis; Andreas Schwingshackl; C D Milne; Marek Duszyk; Morley D Hollenberg; John L Wallace; A Dean Befus; Redwan Moqbel
Proteinase-activated receptor-2-mediated matrix metalloproteinase-9 release from airway epithelial cells.
The Journal of allergy and clinical immunology 2000;106(3):537-45.
2000: John L Wallace; Webb McKnight; BK Reuter; Nathalie Vergnolle
NSAID-induced gastric damage in rats: requirement for inhibition of both cyclooxygenase 1 and 2.
Gastroenterology 2000;119(3):706-14.
2000: John L Wallace; M J Miller
Nitric oxide in mucosal defense: a little goes a long way.
Gastroenterology 2000;119(2):512-20.
2000: Marcelo N Muscará; Webb McKnight; Fina Lovren; Chris R Triggle; Giuseppe Cirino; John L Wallace
Antihypertensive properties of a nitric oxide-releasing naproxen derivative in two-kidney, one-clip rats.
American journal of physiology. Heart and circulatory physiology 2000;279(2):H528-35.
2000: L Ma; John L Wallace
Endothelial nitric oxide synthase modulates gastric ulcer healing in rats.
American journal of physiology. Gastrointestinal and liver physiology 2000;279(2):G341-6.
2000: Carla Cicala; ANGELA IANARO; Stefano Fiorucci; Antonio Calignano; Mariarosaria Bucci; R Gerli; Luca Santucci; John L Wallace; Giuseppe Cirino
NO-naproxen modulates inflammation, nociception and downregulates T cell response in rat Freund's adjuvant arthritis.
British journal of pharmacology 2000;130(6):1399-405.
2000: Maureen N Ajuebor; A Singh; John L Wallace
Cyclooxygenase-2-derived prostaglandin D(2) is an early anti-inflammatory signal in experimental colitis.
American journal of physiology. Gastrointestinal and liver physiology 2000;279(1):G238-44.
2000: Donna-Marie McCafferty; Elaine Sihota; Marcelo N Muscara; John L Wallace; Keith Sharkey; Paul Kubes
Spontaneously developing chronic colitis in IL-10/iNOS double-deficient mice.
American journal of physiology. Gastrointestinal and liver physiology 2000;279(1):G90-9.
2000: Marcelo N Muscará; Nathalie Vergnolle; Fina Lovren; Chris R Triggle; SN Elliott; Samuel Asfaha; John L Wallace
Selective cyclo-oxygenase-2 inhibition with celecoxib elevates blood pressure and promotes leukocyte adherence.
British journal of pharmacology 2000;129(7):1423-30.
2000: John L Wallace
How do NSAIDs cause ulcer disease?
Baillière's best practice & research. Clinical gastroenterology 2000;14(1):147-59.
2000: Marcelo N Muscará; Webb McKnight; Samuel Asfaha; John L Wallace
Wound collagen deposition in rats: effects of an NO-NSAID and a selective COX-2 inhibitor.
British journal of pharmacology 2000;129(4):681-6.
2000: SN Elliott; John L Wallace; Webb McKnight; D Grant Gall; James A Hardin; M Olson; Andre G Buret
Bacterial colonization and healing of gastric ulcers: the effects of epidermal growth factor.
American journal of physiology. Gastrointestinal and liver physiology 2000;278(1):G105-12.
1999: John L Wallace
Distribution and expression of cyclooxygenase (COX) isoenzymes, their physiological roles, and the categorization of nonsteroidal anti-inflammatory drugs (NSAIDs).
The American journal of medicine 1999;107(6A):11S-16S; discussion 16S-17S.
1999: John L Wallace; Michael Dicay; Webb McKnight; S Bastaki; M A Blank
N-bisphosphonates cause gastric epithelial injury independent of effects on the microcirculation.
Alimentary pharmacology & therapeutics 1999;13(12):1675-82.
1999: BK Reuter; John L Wallace
Phosphodiesterase inhibitors prevent NSAID enteropathy independently of effects on TNF-alpha release.
The American journal of physiology 1999;277(4 Pt 1):G847-54.
1999: John L Wallace; Nathalie Vergnolle; Marcelo N Muscará; Samuel Asfaha; Kevin Chapman; Webb McKnight; Piero Del Soldato; A Morelli; Stefano Fiorucci
Enhanced anti-inflammatory effects of a nitric oxide-releasing derivative of mesalamine in rats.
Gastroenterology 1999;117(3):557-66.
1999: Nathalie Vergnolle; Morley D Hollenberg; Keith Sharkey; John L Wallace
Characterization of the inflammatory response to proteinase-activated receptor-2 (PAR2)-activating peptides in the rat paw.
British journal of pharmacology 1999;127(5):1083-90.
1999: Marcelo N Muscará; John L Wallace
Nitric Oxide. V. therapeutic potential of nitric oxide donors and inhibitors.
The American journal of physiology 1999;276(6 Pt 1):G1313-6.
1999: Nathalie Vergnolle; Morley D Hollenberg; John L Wallace
Pro- and anti-inflammatory actions of thrombin: a distinct role for proteinase-activated receptor-1 (PAR1).
British journal of pharmacology 1999;126(5):1262-8.
1999: John L Wallace; Kevin Chapman; Webb McKnight
Limited anti-inflammatory efficacy of cyclo-oxygenase-2 inhibition in carrageenan-airpouch inflammation.
British journal of pharmacology 1999;126(5):1200-4.
1999: S M Bastaki; John L Wallace
Pathogenesis of nonsteroidal anti-inflammatory drug gastropathy: clues to preventative therapy.
Canadian journal of gastroenterology = Journal canadien de gastroenterologie 1999;13(2):123-7.
1999: Samuel Asfaha; C J Bell; John L Wallace; Wallace K MacNaughton
Prolonged colonic epithelial hyporesponsiveness after colitis: role of inducible nitric oxide synthase.
The American journal of physiology 1999;276(3 Pt 1):G703-10.
1999: John L Wallace
Selective COX-2 inhibitors: is the water becoming muddy?
Trends in pharmacological sciences 1999;20(1):4-6.
1999: John L Wallace; Marcelo N Muscara; Webb McKnight; Michael Dicay; Piero Del Soldato; G Cirino
In vivo antithrombotic effects of a nitric oxide-releasing aspirin derivative, NCX-4016.
Thrombosis research 1999;93(1):43-50.
1998: SN Elliott; John L Wallace
Nitric oxide: a regulator of mucosal defense and injury.
Journal of gastroenterology 1998;33(6):792-803.
1998: SN Elliott; John L Wallace
Neutrophil-mediated gastrointestinal injury.
Canadian journal of gastroenterology = Journal canadien de gastroenterologie 1998;12(8):559-68.
1998: SN Elliott; Andre G Buret; Webb McKnight; M J Miller; John L Wallace
Bacteria rapidly colonize and modulate healing of gastric ulcers in rats.
The American journal of physiology 1998;275(3 Pt 1):G425-32.
1998: John L Wallace; AW Bak; Webb McKnight; Samuel Asfaha; Keith Sharkey; Wallace K MacNaughton
Cyclooxygenase 1 contributes to inflammatory responses in rats and mice: implications for gastrointestinal toxicity.
Gastroenterology 1998;115(1):101-9.
1998: Nathalie Vergnolle; Wallace K MacNaughton; Bahjat Al-Ani; Mahmoud Saifeddine; John L Wallace; Morley D Hollenberg
Proteinase-activated receptor 2 (PAR2)-activating peptides: identification of a receptor distinct from PAR2 that regulates intestinal transport.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(13):7766-71.
1998: John L Wallace; Webb McKnight; Samuel Asfaha; D Y Liu
Reduction of acute and reactivated colitis in rats by an inhibitor of neutrophil activation.
The American journal of physiology 1998;274(5 Pt 1):G802-8.
1998: Marcel Miampamba; EJ Parr; Donna-Marie McCafferty; John L Wallace; Keith Sharkey
Effect of intracolonic benzalkonium chloride on trinitrobenzene sulphonic acid-induced colitis in the rat.
Alimentary pharmacology & therapeutics 1998;12(3):219-28.
1998: John L Wallace; Donna-Marie McCafferty; Keith Sharkey
Lack of beneficial effect of a tachykinin receptor antagonist in experimental colitis.
Regulatory peptides 1998;73(2):95-101.
1998: John L Wallace; BK Reuter; Webb McKnight; AW Bak
Selective inhibitors of cyclooxygenase-2: are they really effective, selective, and GI-safe?
Journal of clinical gastroenterology 1998;27 Suppl 1():S28-34.
1998: AW Bak; Webb McKnight; P Li; Piero Del Soldato; A Calignano; Giuseppe Cirino; John L Wallace
Cyclooxygenase-independent chemoprevention with an aspirin derivative in a rat model of colonic adenocarcinoma.
Life sciences 1998;62(23):PL 367-73.
1998: Marcelo N Muscará; Webb McKnight; Piero Del Soldato; John L Wallace
Effect of a nitric oxide-releasing naproxen derivative on hypertension and gastric damage induced by chronic nitric oxide inhibition in the rat.
Life sciences 1998;62(15):PL235-40.
1998: SN Elliott; Webb McKnight; N M Davies; Wallace K MacNaughton; John L Wallace
Alendronate induces gastric injury and delays ulcer healing in rodents.
Life sciences 1998;62(1):77-91.
1997: Neal M Davies; Keith Sharkey; Samuel Asfaha; Wallace K MacNaughton; John L Wallace
Aspirin causes rapid up-regulation of cyclo-oxygenase-2 expression in the stomach of rats.
Alimentary pharmacology & therapeutics 1997;11(6):1101-8.
1997: John L Wallace; Webb McKnight; Tammy L Wilson; Piero Del Soldato; Giuseppe Cirino
Reduction of shock-induced gastric damage by a nitric oxide-releasing aspirin derivative: role of neutrophils.
The American journal of physiology 1997;273(6 Pt 1):G1246-51.
1997: J G Ferraz; Keith Sharkey; BK Reuter; Samuel Asfaha; AW Tigley; M L Brown; Webb McKnight; John L Wallace
Induction of cyclooxygenase 1 and 2 in the rat stomach during endotoxemia: role in resistance to damage.
Gastroenterology 1997;113(1):195-204.
1997: J G Ferraz; AW Tigley; CB Appleyard; John L Wallace
TNF-alpha contributes to the pathogenesis of ethanol-induced gastric damage in cirrhotic rats.
The American journal of physiology 1997;272(4 Pt 1):G809-14.
1997: John L Wallace
Nonsteroidal anti-inflammatory drugs and gastroenteropathy: the second hundred years.
Gastroenterology 1997;112(3):1000-16.
1997: Donna-Marie McCafferty; John L Wallace; Keith Sharkey
Effects of chemical sympathectomy and sensory nerve ablation on experimental colitis in the rat.
The American journal of physiology 1997;272(2 Pt 1):G272-80.
1997: Mark G Swain; CB Appleyard; John L Wallace; M Maric
TNF-alpha facilitates inflammation-induced glucocorticoid secretion in rats with biliary obstruction.
Journal of hepatology 1997;26(2):361-8.
1997: N M Davies; John L Wallace
Nonsteroidal anti-inflammatory drug-induced gastrointestinal toxicity: new insights into an old problem.
Journal of gastroenterology 1997;32(1):127-33.
1997: Neal M Davies; A G Røseth; CB Appleyard; Webb McKnight; Piero Del Soldato; A Calignano; Giuseppe Cirino; John L Wallace
NO-naproxen vs. naproxen: ulcerogenic, analgesic and anti-inflammatory effects.
Alimentary pharmacology & therapeutics 1997;11(1):69-79.
1997: Paul L Beck; John L Wallace
Cytokines in inflammatory bowel disease.
Mediators of inflammation 1997;6(2):95-103.
1997: BK Reuter; Neal M Davies; John L Wallace
Nonsteroidal anti-inflammatory drug enteropathy in rats: role of permeability, bacteria, and enterohepatic circulation.
Gastroenterology 1997;112(1):109-17.
1996: Neal M Davies; John L Wallace
Selective inhibitors of cyclooxygenase-2. Potential in elderly patients.
Drugs & aging 1996;9(6):406-17.
1996: K P Rioux; John L Wallace
Long-term antigen challenge results in progressively diminished mucosal mast cell degranulation in rats.
Gastroenterology 1996;111(6):1516-23.
1996: John L Wallace
NSAID gastroenteropathy: past, present and future.
Canadian journal of gastroenterology = Journal canadien de gastroenterologie 1996;10(7):451-9.
1996: BK Reuter; Samuel Asfaha; Andre G Buret; Keith Sharkey; John L Wallace
Exacerbation of inflammation-associated colonic injury in rat through inhibition of cyclooxygenase-2.
The Journal of clinical investigation 1996;98(9):2076-85.
1996: John L Wallace; D N Granger
The cellular and molecular basis of gastric mucosal defense.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1996;10(7):731-40.
1996: Giuseppe Cirino; Caroline P D Wheeler-Jones; John L Wallace; Piero Del Soldato; A R Baydoun
Inhibition of inducible nitric oxide synthase expression by novel nonsteroidal anti-inflammatory derivatives with gastrointestinal-sparing properties.
British journal of pharmacology 1996;117(7):1421-6.
1996: K P Rioux; John L Wallace
Mast cells do not contribute to nonsteroidal anti-inflammatory drug-induced gastric mucosal injury in rodents.
Alimentary pharmacology & therapeutics 1996;10(2):173-80.
1996: K P Rioux; Keith Sharkey; John L Wallace; Mark G Swain
Hepatic mucosal mast cell hyperplasia in rats with secondary biliary cirrhosis.
Hepatology (Baltimore, Md.) 1996;23(4):888-95.
1996: CB Appleyard; Donna-Marie McCafferty; AW Tigley; Mark G Swain; John L Wallace
Tumor necrosis factor mediation of NSAID-induced gastric damage: role of leukocyte adherence.
The American journal of physiology 1996;270(1 Pt 1):G42-8.
1996: J Geraldo; P Ferraz; John L Wallace
Prostaglandins modulate the responsiveness of the gastric microcirculation of sodium nitroprusside in cirrhotic rats.
Hepatology (Baltimore, Md.) 1996;23(1):123-9.
1995: John L Wallace; Webb McKnight; Piero Del Soldato; A R Baydoun; Giuseppe Cirino
Anti-thrombotic effects of a nitric oxide-releasing, gastric-sparing aspirin derivative.
The Journal of clinical investigation 1995;96(6):2711-8.
1995: Donna-Marie McCafferty; DN Granger; John L Wallace
Indomethacin-induced gastric injury and leukocyte adherence in arthritic versus healthy rats.
Gastroenterology 1995;109(4):1173-80.
1995: John L Wallace; T Le; L Carter; CB Appleyard; P L Beck
Hapten-induced chronic colitis in the rat: alternatives to trinitrobenzene sulfonic acid.
Journal of pharmacological and toxicological methods 1995;33(4):237-9.
1995: SN Elliott; Webb McKnight; Giuseppe Cirino; John L Wallace
A nitric oxide-releasing nonsteroidal anti-inflammatory drug accelerates gastric ulcer healing in rats.
Gastroenterology 1995;109(2):524-30.
1995: CB Appleyard; John L Wallace
Reactivation of hapten-induced colitis and its prevention by anti-inflammatory drugs.
The American journal of physiology 1995;269(1 Pt 1):G119-25.
1995: Giuseppe Cirino; Carla Cicala; F Mancuso; A R Baydoun; John L Wallace
Flurbinitroxybutylester: a novel anti-inflammatory drug has enhanced antithrombotic activity.
Thrombosis research 1995;79(1):73-81.
1995: John L Wallace; Giuseppe Cirino; G W McKnight; SN Elliott
Reduction of gastrointestinal injury in acute endotoxic shock by flurbiprofen nitroxybutylester.
European journal of pharmacology 1995;280(1):63-8.
1995: John L Wallace; AW Tigley
Review article: new insights into prostaglandins and mucosal defence.
Alimentary pharmacology & therapeutics 1995;9(3):227-35.
1995: C J Bell; D Grant Gall; John L Wallace
Disruption of colonic electrolyte transport in experimental colitis.
The American journal of physiology 1995;268(4 Pt 1):G622-30.
1995: J G Ferraz; Webb McKnight; Keith Sharkey; John L Wallace
Impaired vasodilatory responses in the gastric microcirculation of anesthetized rats with secondary biliary cirrhosis.
Gastroenterology 1995;108(4):1183-91.
1995: John L Wallace; G W McKnight; C J Bell
Adaptation of rat gastric mucosa to aspirin requires mucosal contact.
The American journal of physiology 1995;268(1 Pt 1):G134-8.
1995: L Carter; John L Wallace
Alterations in rat peripheral blood neutrophil function as a consequence of colitis.
Digestive diseases and sciences 1995;40(1):192-7.
1995: John L Wallace; Q J Pittman; Giuseppe Cirino
Nitric oxide-releasing NSAIDs: a novel class of GI-sparing anti-inflammatory drugs.
Agents and actions. Supplements 1995;46():121-9.
1995: G H Curtis; Wallace K MacNaughton; D Grant Gall; John L Wallace
Intraluminal pH modulates gastric prostaglandin synthesis.
Canadian journal of physiology and pharmacology 1995;73(1):130-4.
1994: John L Wallace; L Carter; Webb McKnight; Susanne Tries; Stefan Laufer
ML 3000 reduces gastric prostaglandin synthesis without causing mucosal injury.
European journal of pharmacology 1994;271(2-3):525-31.
1994: John L Wallace
The 1994 Merck Frosst Award. Mechanisms of nonsteroidal anti-inflammatory drug (NSAID) induced gastrointestinal damage--potential for development of gastrointestinal tract safe NSAIDs.
Canadian journal of physiology and pharmacology 1994;72(12):1493-8.
1994: John L Wallace; G Cirino
The development of gastrointestinal-sparing nonsteroidal anti-inflammatory drugs.
Trends in pharmacological sciences 1994;15(11):405-6.
1994: J G Ferraz; AW Tigley; John L Wallace
Paradoxical effects of L-arginine on gastric mucosal integrity.
European journal of pharmacology 1994;260(1):107-11.
1994: John L Wallace; BK Reuter; Carla Cicala; Webb McKnight; M B Grisham; Giuseppe Cirino
Novel nonsteroidal anti-inflammatory drug derivatives with markedly reduced ulcerogenic properties in the rat.
Gastroenterology 1994;107(1):173-9.
1994: John L Wallace; BK Reuter; Carla Cicala; Webb McKnight; M Grisham; Giuseppe Cirino
A diclofenac derivative without ulcerogenic properties.
European journal of pharmacology 1994;257(3):249-55.
1994: K P Rioux; John L Wallace
Mast cell activation augments gastric mucosal injury through a leukotriene-dependent mechanism.
The American journal of physiology 1994;266(5 Pt 1):G863-9.
1994: Lloyd R Sutherland; M Verhoef; John L Wallace; Guido M A Van Rosendaal; R Crutcher; Jonathan B Meddings
A simple, non-invasive marker of gastric damage: sucrose permeability.
Lancet 1994;343(8904):998-1000.
1994: Donna-Marie McCafferty; Keith Sharkey; John L Wallace
Beneficial effects of local or systemic lidocaine in experimental colitis.
The American journal of physiology 1994;266(4 Pt 1):G560-7.
1994: V C Dias; Eldon A Shaffer; John L Wallace; Howard G Parsons
Bile salts determine leukotriene B4 synthesis in a human intestinal cell line (CaCo-2).
Digestive diseases and sciences 1994;39(4):802-8.
1994: S Kanwar; John L Wallace; D Befus; Paul Kubes
Nitric oxide synthesis inhibition increases epithelial permeability via mast cells.
The American journal of physiology 1994;266(2 Pt 1):G222-9.
1994: L E Hierlihy; John L Wallace; Alastair V Ferguson
Autonomic pathways in development of neural stimulation-induced gastric mucosal damage.
The American journal of physiology 1994;266(2 Pt 1):G179-85.
1994: BK Reuter; Giuseppe Cirino; John L Wallace
Markedly reduced intestinal toxicity of a diclofenac derivative.
Life sciences 1994;55(1):PL1-8.
1994: John L Wallace; BK Reuter; Giuseppe Cirino
Nitric oxide-releasing non-steroidal anti-inflammatory drugs: a novel approach for reducing gastrointestinal toxicity.
Journal of gastroenterology and hepatology 1994;9 Suppl 1():S40-4.
1993: John L Wallace; Donna-Marie McCafferty; L Carter; Webb McKnight; Dennis Argentieri
Tissue-selective inhibition of prostaglandin synthesis in rat by tepoxalin: anti-inflammatory without gastropathy?
Gastroenterology 1993;105(6):1630-6.
1993: P L Beck; G W McKnight; J K Kelly; John L Wallace; Samuel S Lee
Hepatic and gastric cytoprotective effects of long-term prostaglandin E1 administration in cirrhotic rats.
Gastroenterology 1993;105(5):1483-9.
1993: John L Wallace; Webb McKnight; M Miyasaka; T Tamatani; J Paulson; D C Anderson; DN Granger; Paul Kubes
Role of endothelial adhesion molecules in NSAID-induced gastric mucosal injury.
The American journal of physiology 1993;265(5 Pt 1):G993-8.
1993: Cory M Hogaboam; A Dean Befus; John L Wallace
Modulation of rat mast cell reactivity by IL-1 beta. Divergent effects on nitric oxide and platelet-activating factor release.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(7):3767-74.
1993: L E Hierlihy; John L Wallace; Alastair V Ferguson
Role of gastric acid secretion and blood flow in the development of vagal stimulation induced gastric mucosal damage.
Canadian journal of physiology and pharmacology 1993;71(10-11):829-34.
1993: P L Beck; Webb McKnight; Samuel S Lee; John L Wallace
Prostaglandin modulation of the gastric vasculature and mucosal integrity in cirrhotic rats.
The American journal of physiology 1993;265(3 Pt 1):G453-8.
1993: A Higa; G W McKnight; John L Wallace
Attenuation of epithelial injury in acute experimental colitis by immunomodulators.
European journal of pharmacology 1993;239(1-3):171-6.
1993: C J Bell; John L Wallace
Corticosteroid drugs and inflammation: the endothelial-leukocyte interface as a target for therapeutics.
Journal of pediatric gastroenterology and nutrition 1993;17(1):113-4.
1993: John L Wallace; G W McKnight
Characterization of a simple animal model for nonsteroidal anti-inflammatory drug induced antral ulcer.
Canadian journal of physiology and pharmacology 1993;71(7):447-52.
1993: Jonathan B Meddings; Lloyd R Sutherland; N I Byles; John L Wallace
Sucrose: a novel permeability marker for gastroduodenal disease.
Gastroenterology 1993;104(6):1619-26.
1993: John L Wallace; G W McKnight; D Donigi-Gale; T S Shoupe; DN Granger
Protective effects of PF-10040 in experimental NSAID-gastritis: role of leukocytes, leukotrienes and PAF.
Journal of lipid mediators 1993;7(2):183-96.
1993: Donna-Marie McCafferty; Paul Kubes; John L Wallace
Inhibition of platelet-activating factor-induced leukocyte adhesion in vivo by a leumedin.
European journal of pharmacology 1993;232(2-3):169-72.
1993: S M Freedman; John L Wallace; Eldon A Shaffer
Characterization of leukotriene-induced contraction of the guinea-pig gallbladder in vitro.
Canadian journal of physiology and pharmacology 1993;71(2):145-50.
1993: John L Wallace
Gastric ulceration: critical events at the neutrophil--endothelium interface.
Canadian journal of physiology and pharmacology 1993;71(1):98-102.
1993: Cory M Hogaboam; Elyse Y Bissonnette; B C Chin; A Dean Befus; John L Wallace
Prostaglandins inhibit inflammatory mediator release from rat mast cells.
Gastroenterology 1993;104(1):122-9.
1992: John L Wallace; K P Rioux; Webb McKnight; L Carter; D Jourd'heuil; Jonathan B Meddings; B J Zimmerman; DN Granger; M B Grisham
Hemoprotein-dependent production of a neutrophil-activating factor from arachidonic acid.
The American journal of physiology 1992;263(5 Pt 2):H1546-53.
1992: John L Wallace
Prostaglandins, NSAIDs, and cytoprotection.
Gastroenterology clinics of North America 1992;21(3):631-41.
1992: P L Beck; Samuel S Lee; G W McKnight; John L Wallace
Characterization of spontaneous and ethanol-induced gastric damage in cirrhotic rats.
Gastroenterology 1992;103(3):1048-55.
1992: Luca Parente; Mauro Perretti; John L Wallace; K G Mugridge
Mechanism of the protective action of interleukin-1 in the experimental gastric damage in the rat.
Pharmacological research : the official journal of the Italian Pharmacological Society 1992;26 Suppl 2():28-9.
1992: John L Wallace; G W McKnight; A Dean Befus
Capsaicin-induced hyperemia in the stomach: possible contribution of mast cells.
The American journal of physiology 1992;263(2 Pt 1):G209-14.
1992: L E Hierlihy; John L Wallace; Alastair V Ferguson
Neurally mediated gastric mucosal damage in hypophysectomized rats.
Canadian journal of physiology and pharmacology 1992;70(8):1109-16.
1992: John L Wallace; A Higa; G W McKnight; D E MacIntyre
Prevention and reversal of experimental colitis by a monoclonal antibody which inhibits leukocyte adherence.
Inflammation 1992;16(4):343-54.
1992: Cory M Hogaboam; D Donigi-Gale; T S Shoupe; John L Wallace
PF-5901 inhibits gastrointestinal platelet-activating factor synthesis in vivo.
European journal of pharmacology 1992;216(2):315-8.
1992: Mauro Perretti; K G Mugridge; John L Wallace; Luca Parente
Reduction of aspirin-induced gastric damage in rats by interleukin-1 beta: possible involvement of endogenous corticosteroids.
The Journal of pharmacology and experimental therapeutics 1992;261(3):1238-47.
1992: P M Vaananen; C M Keenan; M B Grisham; John L Wallace
Pharmacological investigation of the role of leukotrienes in the pathogenesis of experimental NSAID gastropathy.
Inflammation 1992;16(3):227-40.
1992: V C Dias; John L Wallace; Howard G Parsons
Modulation of cellular phospholipid fatty acids and leukotriene B4 synthesis in the human intestinal cell (CaCo-2).
Gut 1992;33(5):622-7.
1992: John L Wallace; D N Granger
Pathogenesis of NSAID gastropathy: are neutrophils the culprits?
Trends in pharmacological sciences 1992;13(4):129-31.
1992: John L Wallace; C M Keenan; M Cucala; K G Mugridge; Luca Parente
Mechanisms underlying the protective effects of interleukin 1 in experimental nonsteroidal anti-inflammatory drug gastropathy.
Gastroenterology 1992;102(4 Pt 1):1176-85.
1992: Cory M Hogaboam; D Donigi-Gale; T S Shoupe; Elyse Y Bissonnette; A Dean Befus; John L Wallace
Platelet-activating factor synthesis by peritoneal mast cells and its inhibition by two quinoline-based compounds.
British journal of pharmacology 1992;105(1):87-92.
1992: S M Freedman; D K Basu; John L Wallace; Eldon A Shaffer
Leukotriene-induced contraction of isolated guinea pig gallbladder (GB) strips.
Advances in experimental medicine and biology 1992;311():437-8.
1992: John L Wallace; Cory M Hogaboam; P Kubes
Immunopathology of NSAID-gastropathy: inhibitory effects of interleukin-I and cyclosporin A.
Annals of the New York Academy of Sciences 1992;664():400-7.
1992: John L Wallace
Non-steroidal anti-inflammatory drug gastropathy and cytoprotection: pathogenesis and mechanisms re-examined.
Scandinavian journal of gastroenterology. Supplement 1992;192():3-8.
1992: Donna-Marie McCafferty; K J Rioux; John L Wallace
Granulocyte infiltration in experimental colitis in the rat is interleukin-1 dependent and leukotriene independent.
Eicosanoids 1992;5(3-4):121-5.
1992: John L Wallace; C M Keenan; D Gale; T S Shoupe
Exacerbation of experimental colitis by nonsteroidal anti-inflammatory drugs is not related to elevated leukotriene B4 synthesis.
Gastroenterology 1992;102(1):18-27.
1991: Jonathan B Meddings; Cory M Hogaboam; K Tran; J D Reynolds; John L Wallace
Capsaicin effects on non-neuronal plasma membranes.
Biochimica et biophysica acta 1991;1070(1):43-50.
1991: Elyse Y Bissonnette; Cory M Hogaboam; John L Wallace; A Dean Befus
Potentiation of tumor necrosis factor-alpha-mediated cytotoxicity of mast cells by their production of nitric oxide.
Journal of immunology (Baltimore, Md. : 1950) 1991;147(9):3060-5.
1991: John L Wallace; M Cucala; K Mugridge; Luca Parente
Secretagogue-specific effects of interleukin-1 on gastric acid secretion.
The American journal of physiology 1991;261(4 Pt 1):G559-64.
1991: Cory M Hogaboam; John L Wallace
Inhibition of platelet aggregation by capsaicin. An effect unrelated to actions on sensory afferent neurons.
European journal of pharmacology 1991;202(1):129-31.
1991: P M Vaananen; Jonathan B Meddings; John L Wallace
Role of oxygen-derived free radicals in indomethacin-induced gastric injury.
The American journal of physiology 1991;261(3 Pt 1):G470-5.
1991: John L Wallace; Giuseppe Cirino; Carla Cicala; D W Anderson; Dennis Argentieri; R J Capetola
Comparison of the ulcerogenic properties of tepoxalin with those of non-steroidal anti-inflammatory drugs (NSAIDs).
Agents and actions 1991;34(1-2):247-50.
1991: Cory M Hogaboam; A Dean Befus; John L Wallace
Intestinal platelet-activating factor synthesis during Nippostrongylus brasiliensis infection in the rat.
Journal of lipid mediators 1991;4(2):211-24.
1991: L E Hierlihy; John L Wallace; Alastair V Ferguson
Vagal stimulation-induced gastric damage in rats.
The American journal of physiology 1991;261(1 Pt 1):G104-10.
1991: John L Wallace; K E Arfors; G W McKnight
A monoclonal antibody against the CD18 leukocyte adhesion molecule prevents indomethacin-induced gastric damage in the rabbit.
Gastroenterology 1991;100(4):878-83.
1991: John L Wallace
Possible mechanisms and mediators of gastritis associated with Helicobacter pylori infection.
Scandinavian journal of gastroenterology. Supplement 1991;187():65-70.
1990: John L Wallace; C M Keenan; K G Mugridge; Luca Parente
Reduction of the severity of experimental gastric and duodenal ulceration by interleukin-1 beta.
European journal of pharmacology 1990;186(2-3):279-84.
1990: Ronald Mathison; C Rimmer; Joseph S Davison; John L Wallace; A Dean Befus
Alterations in regional blood flow in rats following sensitization to the nematode Nippostrongylus brasiliensis: effects of PAF antagonists.
British journal of pharmacology 1990;101(1):93-6.
1990: John L Wallace; C M Keenan; DN Granger
Gastric ulceration induced by nonsteroidal anti-inflammatory drugs is a neutrophil-dependent process.
The American journal of physiology 1990;259(3 Pt 1):G462-7.
1990: John L Wallace; G W McKnight
The mucoid cap over superficial gastric damage in the rat. A high-pH microenvironment dissipated by nonsteroidal antiinflammatory drugs and endothelin.
Gastroenterology 1990;99(2):295-304.
1990: John L Wallace; Cory M Hogaboam; G W McKnight
Platelet-activating factor mediates gastric damage induced by hemorrhagic shock.
The American journal of physiology 1990;259(1 Pt 1):G140-6.
1990: John L Wallace; G W McKnight
Comparison of the damage-promoting effects of leukotrienes derived from eicosapentaenoic acid and arachidonic acid on the rat stomach.
The Journal of experimental medicine 1990;171(5):1827-32.
1990: John L Wallace; C M Keenan
Leukotriene B4 potentiates colonic ulceration in the rat.
Digestive diseases and sciences 1990;35(5):622-9.
1990: John L Wallace; G W McKnight; C M Keenan; N I Byles; Wallace K MacNaughton
Effects of leukotrienes on susceptibility of the rat stomach to damage and investigation of the mechanism of action.
Gastroenterology 1990;98(5 Pt 1):1178-86.
1990: John L Wallace; C M Keenan
An orally active inhibitor of leukotriene synthesis accelerates healing in a rat model of colitis.
The American journal of physiology 1990;258(4 Pt 1):G527-34.
1990: John L Wallace
Mucosal defense. New avenues for treatment of ulcer disease?
Gastroenterology clinics of North America 1990;19(1):87-100.
1990: John L Wallace
5-Lipoxygenase: a rational target for therapy of inflammatory bowel disease?
Trends in pharmacological sciences 1990;11(2):51-3.
1990: John L Wallace
Lipid mediators of inflammation in gastric ulcer.
The American journal of physiology 1990;258(1 Pt 1):G1-11.
1989: Francisco Guarner; John L Wallace; Wallace K MacNaughton; G C Ibbotson; Vicente Arroyo; Juan Rodés
Endotoxin-induced ascites formation in the rat: partial mediation by platelet-activating factor.
Hepatology (Baltimore, Md.) 1989;10(5):788-94.
1989: G C Ibbotson; John L Wallace
Inhibitory effects of dexamethasone in endotoxic shock and its relation to PAF-acether synthesis in the gastrointestinal tract and lung.
Journal of lipid mediators 1989;1(5):273-82.
1989: John L Wallace; C M Keenan; Wallace K MacNaughton; G W McKnight
Comparison of the effects of endothelin-1 and endothelin-3 on the rat stomach.
European journal of pharmacology 1989;167(1):41-7.
1989: Gerald P Morris; C M Keenan; Wallace K MacNaughton; John L Wallace; T E Williamson
Protection of rat gastric mucosa by sucralfate. Effects of luminal stasis and of inhibition of prostaglandins synthesis.
The American journal of medicine 1989;86(6A):10-6.
1989: John L Wallace; Giuseppe Cirino; G De Nucci; Webb McKnight; Wallace K MacNaughton
Endothelin has potent ulcerogenic and vasoconstrictor actions in the stomach.
The American journal of physiology 1989;256(4 Pt 1):G661-6.
1989: Wallace K MacNaughton; John L Wallace
A role for dopamine as an endogenous protective factor in the rat stomach.
Gastroenterology 1989;96(4):972-80.
1989: P L Beck; Gerald P Morris; John L Wallace
Reduction of ethanol-induced gastric damage by sodium cromoglycate and FPL-52694. Role of leukotrienes, prostaglandins, and mast cells in the protective mechanism.
Canadian journal of physiology and pharmacology 1989;67(4):287-93.
1989: Gerald P Morris; P L Beck; M S Herridge; William T Depew; Myron R Szewczuk; John L Wallace
Hapten-induced model of chronic inflammation and ulceration in the rat colon.
Gastroenterology 1989;96(3):795-803.
1989: G C Ibbotson; John L Wallace
Beneficial effects of prostaglandin E2 in endotoxic shock are unrelated to effects on PAF-acether synthesis.
Prostaglandins 1989;37(2):237-50.
1989: John L Wallace
Extracellular mucus and repair of superficial mucosal injury by restitution.
Methods and findings in experimental and clinical pharmacology 1989;11 Suppl 1():27-33.
1989: John L Wallace; Wallace K MacNaughton; Gerald P Morris; P L Beck
Inhibition of leukotriene synthesis markedly accelerates healing in a rat model of inflammatory bowel disease.
Gastroenterology 1989;96(1):29-36.
1989: John L Wallace; P Braquet; G C Ibbotson; Wallace K MacNaughton; Giuseppe Cirino
Assessment of the role of platelet-activating factor in an animal model of inflammatory bowel disease.
Journal of lipid mediators 1989;1(1):13-23.
1989: Wallace K MacNaughton; Giuseppe Cirino; John L Wallace
Endothelium-derived relaxing factor (nitric oxide) has protective actions in the stomach.
Life sciences 1989;45(20):1869-76.
1989: John L Wallace
Gastric resistance to acid: is the "mucus-bicarbonate barrier" functionally redundant?
The American journal of physiology 1989;256(1 Pt 1):G31-8.
1989: Wallace K MacNaughton; C M Keenan; G W McKnight; John L Wallace
The modulation of gastric mucosal integrity by endothelin-1 and prostacyclin.
Journal of cardiovascular pharmacology 1989;13 Suppl 5():S118-22; discussion S123.
1988: Alastair V Ferguson; P Marcus; J Spencer; John L Wallace
Paraventricular nucleus stimulation causes gastroduodenal mucosal necrosis in the rat.
The American journal of physiology 1988;255(5 Pt 2):R861-5.
1988: John L Wallace; Wallace K MacNaughton
Gastrointestinal damage induced by platelet-activating factor: role of leukotrienes.
European journal of pharmacology 1988;151(1):43-50.
1988: John L Wallace; Gerald P Morris; P L Beck; T E Williamson; G R Gingras
Effects of sucralfate on gastric prostaglandin and leukotriene synthesis: relationship to protective actions.
Canadian journal of physiology and pharmacology 1988;66(5):666-70.
1988: John L Wallace
Release of platelet-activating factor (PAF) and accelerated healing induced by a PAF antagonist in an animal model of chronic colitis.
Canadian journal of physiology and pharmacology 1988;66(4):422-5.
1988: John L Wallace; P L Beck; Gerald P Morris
Is there a role for leukotrienes as mediators of ethanol-induced gastric mucosal damage?
The American journal of physiology 1988;254(1 Pt 1):G117-23.
1988: John L Wallace
Increased resistance of the rat gastric mucosa to hemorrhagic damage after exposure to an irritant. Role of the "mucoid cap" and prostaglandin synthesis.
Gastroenterology 1988;94(1):22-32.
1987: John L Wallace
Glucocorticoid-induced gastric mucosal damage: inhibition of leukotriene, but not prostaglandin biosynthesis.
Prostaglandins 1987;34(2):311-23.
1987: John L Wallace; G Steel; B J Whittle
Gastrointestinal plasma leakage in endotoxic shock. Inhibition by prostaglandin E2 and by a platelet-activating factor antagonist.
Canadian journal of physiology and pharmacology 1987;65(7):1428-32.