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Thomas Walle

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Co-Publications
Name
80
Walle, Kristina
12
Webb, Jerry
12
Knapp, Daniel
9
Bai, Stephen
9
Oatis, John
8
Otake, Yoko
6
Wen, Xia
5
Walgren, Richard
5
Tsuji, Petra
5
Galijatovic, A
4
McMillan, JoEllyn
4
Halushka, Perry
4
Bhalla, Kapil
3
Whitley, Alexander
3
Vaidyanathan, Jaya Bharathi

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Publications

TOP 3
Tsuji P A; Walle T
Cytotoxic effects of the dietary flavones chrysin and apigenin in a normal trout liver cell line.
Walle Thomas
Methylation of dietary flavones greatly improves their hepatic metabolic stability and intestinal absorption.
Walle U Kristina; Walle Thomas
Bioavailable flavonoids: cytochrome P450-mediated metabolism of methoxyflavones.

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All Publications

2008: Tsuji P A; Walle T
Cytotoxic effects of the dietary flavones chrysin and apigenin in a normal trout liver cell line.
Chemico-biological interactions 2008;171(1):37-44.
2007: Walle Thomas
Methylation of dietary flavones greatly improves their hepatic metabolic stability and intestinal absorption.
Molecular pharmaceutics 2007;4(6):826-32.
2007: Walle U Kristina; Walle Thomas
Bioavailable flavonoids: cytochrome P450-mediated metabolism of methoxyflavones.
Drug metabolism and disposition: the biological fate of chemicals 2007;35(11):1985-9.
2007: Ta Nga; Walle Thomas
Aromatase inhibition by bioavailable methylated flavones.
The Journal of steroid biochemistry and molecular biology 2007;107(1-2):127-9.
2007: Walle Thomas
Methoxylated flavones, a superior cancer chemopreventive flavonoid subclass?
Seminars in cancer biology 2007;17(5):354-62.
2007: Tsuji Petra A; Walle Thomas
Benzo[a]pyrene-induced cytochrome P450 1A and DNA binding in cultured trout hepatocytes - inhibition by plant polyphenols.
Chemico-biological interactions 2007;169(1):25-31.
2007: Walle Thomas; Walle U Kristina
Novel methoxylated flavone inhibitors of cytochrome P450 1B1 in SCC-9 human oral cancer cells.
The Journal of pharmacy and pharmacology 2007;59(6):857-62.
2007: Walle Thomas; Wen Xia; Walle U Kristina
Improving metabolic stability of cancer chemoprotective polyphenols.
Expert opinion on drug metabolism & toxicology 2007;3(3):379-88.
2007: Walle Thomas; Ta Nga; Kawamori Toshihiko; Wen Xia; Tsuji Petra A; Walle U Kristina
Cancer chemopreventive properties of orally bioavailable flavonoids--methylated versus unmethylated flavones.
Biochemical pharmacology 2007;73(9):1288-96.
2007: Wen Xia; Walle Thomas
Cytochrome P450 1B1, a novel chemopreventive target for benzo[a]pyrene-initiated human esophageal cancer.
Cancer letters 2007;246(1-2):109-14.
2006: Tsuji Petra A; Winn Richard N; Walle Thomas
Accumulation and metabolism of the anticancer flavonoid 5,7-dimethoxyflavone compared to its unmethylated analog chrysin in the Atlantic killifish.
Chemico-biological interactions 2006;164(1-2):85-92.
2006: Wen Xia; Walle Thomas
Methylated flavonoids have greatly improved intestinal absorption and metabolic stability.
Drug metabolism and disposition: the biological fate of chemicals 2006;34(10):1786-92.
2006: Whitley Alexander C; Sweet Douglas H; Walle Thomas
Site-specific accumulation of the cancer preventive dietary polyphenol ellagic acid in epithelial cells of the aerodigestive tract.
The Journal of pharmacy and pharmacology 2006;58(9):1201-9.
2006: Tsuji Petra A; Walle Thomas
Inhibition of benzo[a]pyrene-activating enzymes and DNA binding in human bronchial epithelial BEAS-2B cells by methoxylated flavonoids.
Carcinogenesis 2006;27(8):1579-85.
2006: Wen X; Walle T
Methylation protects dietary flavonoids from rapid hepatic metabolism.
Xenobiotica; the fate of foreign compounds in biological systems 2006;36(5):387-97.
2006: Walle Thomas; Walle U Kristina; Sedmera David; Klausner Mitch
Benzo[A]pyrene-induced oral carcinogenesis and chemoprevention: studies in bioengineered human tissue.
Drug metabolism and disposition: the biological fate of chemicals 2006;34(3):346-50.
2005: van der Woude Hester; Alink Gerrit M; van Rossum Bart E J; Walle Kristina; van Steeg Harry; Walle Thomas; Rietjens Ivonne M C M
Formation of transient covalent protein and DNA adducts by quercetin in cells with and without oxidative enzyme activity.
Chemical research in toxicology 2005;18(12):1907-16.
2005: Wen Xia; Walle Thomas
Preferential induction of CYP1B1 by benzo[a]pyrene in human oral epithelial cells: impact on DNA adduct formation and prevention by polyphenols.
Carcinogenesis 2005;26(10):1774-81.
2005: Browning Alyson M; Walle U Kristina; Walle Thomas
Flavonoid glycosides inhibit oral cancer cell proliferation--role of cellular uptake and hydrolysis to the aglycones.
The Journal of pharmacy and pharmacology 2005;57(8):1037-42.
2005: Whitley Alexander C; Sweet Douglas H; Walle Thomas
The dietary polyphenol ellagic acid is a potent inhibitor of hOAT1.
Drug metabolism and disposition: the biological fate of chemicals 2005;33(8):1097-100.
2005: McMillan J M; Walle U K; Walle T
S-adenosyl-L-methionine: transcellular transport and uptake by Caco-2 cells and hepatocytes.
The Journal of pharmacy and pharmacology 2005;57(5):599-605.
2005: Kaldas Mark I; Walle U Kristina; van der Woude Hester; McMillan JoEllyn M; Walle Thomas
Covalent binding of the flavonoid quercetin to human serum albumin.
Journal of agricultural and food chemistry 2005;53(10):4194-7.
2005: Wen Xia; Walle U Kristina; Walle Thomas
5,7-Dimethoxyflavone downregulates CYP1A1 expression and benzo[a]pyrene-induced DNA binding in Hep G2 cells.
Carcinogenesis 2005;26(4):803-9.
2005: Hadden M Kyle; Walle Thomas; Dix Thomas A
Cellular uptake of a radiolabelled analogue of neurotensin in the Caco-2 cell model.
The Journal of pharmacy and pharmacology 2005;57(3):327-33.
2005: Walle Thomas; Browning Alyson M; Steed Lisa L; Reed Susan G; Walle U Kristina
Flavonoid glucosides are hydrolyzed and thus activated in the oral cavity in humans.
The Journal of nutrition 2005;135(1):48-52.
2005: Haghiac Maricela; Walle Thomas
Quercetin induces necrosis and apoptosis in SCC-9 oral cancer cells.
Nutrition and cancer 2005;53(2):220-31.
2004: Walle Thomas; Hsieh Faye; DeLegge Mark H; Oatis John E; Walle U Kristina
High absorption but very low bioavailability of oral resveratrol in humans.
Drug metabolism and disposition: the biological fate of chemicals 2004;32(12):1377-82.
2004: Walle Thomas
Absorption and metabolism of flavonoids.
Free radical biology & medicine 2004;36(7):829-37.
2003: Walle Thomas; Walle U Kristina
The beta-D-glucoside and sodium-dependent glucose transporter 1 (SGLT1)-inhibitor phloridzin is transported by both SGLT1 and multidrug resistance-associated proteins 1/2.
Drug metabolism and disposition: the biological fate of chemicals 2003;31(11):1288-91.
2003: Vaidyanathan Jaya Bharathi; Walle Thomas
Cellular uptake and efflux of the tea flavonoid (-)epicatechin-3-gallate in the human intestinal cell line Caco-2.
The Journal of pharmacology and experimental therapeutics 2003;307(2):745-52.
2003: Whitley Alexander C; Stoner Gary D; Darby Michael V; Walle Thomas
Intestinal epithelial cell accumulation of the cancer preventive polyphenol ellagic acid--extensive binding to protein and DNA.
Biochemical pharmacology 2003;66(6):907-15.
2003: Walle Thomas; Vincent Timothy S; Walle U Kristina
Evidence of covalent binding of the dietary flavonoid quercetin to DNA and protein in human intestinal and hepatic cells.
Biochemical pharmacology 2003;65(10):1603-10.
2003: Kaldas Mark I; Walle U Kristina; Walle Thomas
Resveratrol transport and metabolism by human intestinal Caco-2 cells.
The Journal of pharmacy and pharmacology 2003;55(3):307-12.
2002: Vaidyanathan Jaya Bharathi; Walle Thomas
Glucuronidation and sulfation of the tea flavonoid (-)-epicatechin by the human and rat enzymes.
Drug metabolism and disposition: the biological fate of chemicals 2002;30(8):897-903.
2002: Otake Yoko; Hsieh Faye; Walle Thomas
Glucuronidation versus oxidation of the flavonoid galangin by human liver microsomes and hepatocytes.
Drug metabolism and disposition: the biological fate of chemicals 2002;30(5):576-81.
2002: Walle U Kristina; Walle Thomas
Induction of human UDP-glucuronosyltransferase UGT1A1 by flavonoids-structural requirements.
Drug metabolism and disposition: the biological fate of chemicals 2002;30(5):564-9.
2002: Otake Yoko; Walle Thomas
Oxidation of the flavonoids galangin and kaempferide by human liver microsomes and CYP1A1, CYP1A2, and CYP2C9.
Drug metabolism and disposition: the biological fate of chemicals 2002;30(2):103-5.
2002: Handley Dean A; Senanayake Chris H; Dutczak William; Benovic Jeffrey L; Walle Thomas; Penn Raymond B; Wilkinson H Scott; Tanoury Gerald J; Andersson Rolf G G; Johansson Fredrik; Morley John
Biological actions of formoterol isomers.
Pulmonary pharmacology & therapeutics 2002;15(2):135-45.
2001: Vaidyanathan J B; Walle T
Transport and metabolism of the tea flavonoid (-)-epicatechin by the human intestinal cell line Caco-2.
Pharmaceutical research 2001;18(10):1420-5.
2001: Walle T; Walle U K; Halushka P V
Carbon dioxide is the major metabolite of quercetin in humans.
The Journal of nutrition 2001;131(10):2648-52.
2001: Galijatovic A; Otake Y; Walle U K; Walle T
Induction of UDP-glucuronosyltransferase UGT1A1 by the flavonoid chrysin in Caco-2 cells--potential role in carcinogen bioinactivation.
Pharmaceutical research 2001;18(3):374-9.
2001: Walle T; Otake Y; Brubaker J A; Walle U K; Halushka P V
Disposition and metabolism of the flavonoid chrysin in normal volunteers.
British journal of clinical pharmacology 2001;51(2):143-6.
2000: Walle T; Otake Y; Walle U K; Wilson F A
Quercetin glucosides are completely hydrolyzed in ileostomy patients before absorption.
The Journal of nutrition 2000;130(11):2658-61.
2000: Walle T; Otake Y; Galijatovic A; Ritter J K; Walle U K
Induction of UDP-glucuronosyltransferase UGT1A1 by the flavonoid chrysin in the human hepatoma cell line hep G2.
Drug metabolism and disposition: the biological fate of chemicals 2000;28(9):1077-82.
2000: Walgren R A; Lin J T; Kinne R K; Walle T
Cellular uptake of dietary flavonoid quercetin 4'-beta-glucoside by sodium-dependent glucose transporter SGLT1.
The Journal of pharmacology and experimental therapeutics 2000;294(3):837-43.
2000: Walgren R A; Karnaky K J; Lindenmayer G E; Walle T
Efflux of dietary flavonoid quercetin 4'-beta-glucoside across human intestinal Caco-2 cell monolayers by apical multidrug resistance-associated protein-2.
The Journal of pharmacology and experimental therapeutics 2000;294(3):830-6.
2000: Otake Y; Nolan A L; Walle U K; Walle T
Quercetin and resveratrol potently reduce estrogen sulfotransferase activity in normal human mammary epithelial cells.
The Journal of steroid biochemistry and molecular biology 2000;73(5):265-70.
2000: Lewis A J; Otake Y; Walle U K; Walle T
Sulphonation of N-hydroxy-2-acetylaminofluorene by human dehydroepiandrosterone sulphotransferase.
Xenobiotica; the fate of foreign compounds in biological systems 2000;30(3):253-61.
2000: Galijatovic A; Walle U K; Walle T
Induction of UDP-glucuronosyltransferase by the flavonoids chrysin and quercetin in Caco-2 cells.
Pharmaceutical research 2000;17(1):21-6.
1999: Galijatovic A; Otake Y; Walle U K; Walle T
Extensive metabolism of the flavonoid chrysin by human Caco-2 and Hep G2 cells.
Xenobiotica; the fate of foreign compounds in biological systems 1999;29(12):1241-56.
1999: Walle U K; Walle T
Transport of the cooked-food mutagen 2-amino-1-methyl-6-phenylimidazo-[4,5-b]pyridine (PhIP) across the human intestinal Caco-2 cell monolayer: role of efflux pumps.
Carcinogenesis 1999;20(11):2153-7.
1999: Walgren R A; Walle T
The influence of plasma binding on absorption/exsorption in the Caco-2 model of human intestinal absorption.
The Journal of pharmacy and pharmacology 1999;51(9):1037-40.
1999: Walle U K; Galijatovic A; Walle T
Transport of the flavonoid chrysin and its conjugated metabolites by the human intestinal cell line Caco-2.
Biochemical pharmacology 1999;58(3):431-8.
1999: Bhalla K N; Kumar G N; Walle U K; Ibrado A M; Javed T; Stuart R K; Reed C; Arbuck S G; Walle T
Phase I and pharmacologic study of a 3-hour infusion of paclitaxel followed by cisplatinum and 5-fluorouracil in patients with advanced solid tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(7):1723-30.
1999: Boulton D W; Walle U K; Walle T
Fate of the flavonoid quercetin in human cell lines: chemical instability and metabolism.
The Journal of pharmacy and pharmacology 1999;51(3):353-9.
1999: Walle U K; French K L; Walgren R A; Walle T
Transport of genistein-7-glucoside by human intestinal CACO-2 cells: potential role for MRP2.
Research communications in molecular pathology and pharmacology 1999;103(1):45-56.
1998: Lewis A J; Walle U K; King R S; Kadlubar F F; Falany C N; Walle T
Bioactivation of the cooked food mutagen N-hydroxy-2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine by estrogen sulfotransferase in cultured human mammary epithelial cells.
Carcinogenesis 1998;19(11):2049-53.
1998: Walgren R A; Walle U K; Walle T
Transport of quercetin and its glucosides across human intestinal epithelial Caco-2 cells.
Biochemical pharmacology 1998;55(10):1721-7.
1998: Walle U K; Walle T
Taxol transport by human intestinal epithelial Caco-2 cells.
Drug metabolism and disposition: the biological fate of chemicals 1998;26(4):343-6.
1998: Boulton D W; Walle U K; Walle T
Extensive binding of the bioflavonoid quercetin to human plasma proteins.
The Journal of pharmacy and pharmacology 1998;50(2):243-9.
1998: Hartman A P; Wilson A A; Wilson H M; Aberg G; Falany C N; Walle T
Enantioselective sulfation of beta 2-receptor agonists by the human intestine and the recombinant M-form phenolsulfotransferase.
Chirality 1998;10(9):800-3.
1997: Wilson A A; Wang J; Koch P; Walle T
Stereoselective sulphate conjugation of fenoterol by human phenolsulphotransferases.
Xenobiotica; the fate of foreign compounds in biological systems 1997;27(11):1147-54.
1996: Lewis A J; Kelly M M; Walle U K; Eaton E A; Falany C N; Walle T
Improved bacterial expression of the human P form phenolsulfotransferase. Applications to drug metabolism.
Drug metabolism and disposition: the biological fate of chemicals 1996;24(11):1180-5.
1996: Walle T; Fagan T C; Walle U K; Topmiller M J
Stimulatory as well as inhibitory effects of ethinyloestradiol on the metabolic clearances of propranolol in young women.
British journal of clinical pharmacology 1996;41(4):305-9.
1996: Eaton E A; Walle U K; Wilson H M; Aberg G; Walle T
Stereoselective sulphate conjugation of salbutamol by human lung and bronchial epithelial cells.
British journal of clinical pharmacology 1996;41(3):201-6.
1996: Eaton E A; Walle U K; Lewis A J; Hudson T; Wilson A A; Walle T
Flavonoids, potent inhibitors of the human P-form phenolsulfotransferase. Potential role in drug metabolism and chemoprevention.
Drug metabolism and disposition: the biological fate of chemicals 1996;24(2):232-7.
1996: Walle T; Eaton E A; Walle U K; Pesola G R
Stereoselective metabolism of RS-albuterol in humans.
Clinical reviews in allergy & immunology 1996;14(1):101-13.
1996: Walle T
Assays of CYP2C8- and CYP3A4-mediated metabolism of taxol in vivo and in vitro.
Methods in enzymology 1996;272():145-51.
1995: Anderson C D; Wang J; Kumar G N; McMillan J M; Walle U K; Walle T
Dexamethasone induction of taxol metabolism in the rat.
Drug metabolism and disposition: the biological fate of chemicals 1995;23(11):1286-90.
1995: Walle T; Eaton E A; Walle U K
Quercetin, a potent and specific inhibitor of the human P-form phenosulfotransferase.
Biochemical pharmacology 1995;50(5):731-4.
1995: Walle T; Walle U K; Kumar G N; Bhalla K N
Taxol metabolism and disposition in cancer patients.
Drug metabolism and disposition: the biological fate of chemicals 1995;23(4):506-12.
1995: Kumar G; Ray S; Walle T; Huang Y; Willingham M; Self S; Bhalla K
Comparative in vitro cytotoxic effects of taxol and its major human metabolite 6 alpha-hydroxytaxol.
Cancer chemotherapy and pharmacology 1995;36(2):129-35.
1995: Wild M D; Walle U K; Walle T
Extensive and saturable accumulation of paclitaxel by the human platelet.
Cancer chemotherapy and pharmacology 1995;36(1):41-4.
1994: Walle T; Walle K; Mathur R S; Palesch Y Y; Conradi E C
Propranolol metabolism in normal subjects: association with sex steroid hormones.
Clinical pharmacology and therapeutics 1994;56(2):127-32.
1994: Walle T; Walle U K; Shwed J A; Thornburg K R; Mathis C E; Pesola G R
Human phenol sulfotransferases: chiral substrates and expression in Hep G2 cells.
Chemico-biological interactions 1994;92(1-3):47-55.
1994: Kumar G N; Walle U K; Walle T
Cytochrome P450 3A-mediated human liver microsomal taxol 6 alpha-hydroxylation.
The Journal of pharmacology and experimental therapeutics 1994;268(3):1160-5.
1994: Walle U K; Fagan T C; Topmiller M J; Conradi E C; Walle T
The influence of gender and sex steroid hormones on the plasma binding of propranolol enantiomers.
British journal of clinical pharmacology 1994;37(1):21-5.
1994: Kumar G N; Oatis J E; Thornburg K R; Heldrich F J; Hazard E S; Walle T
6 alpha-Hydroxytaxol: isolation and identification of the major metabolite of taxol in human liver microsomes.
Drug metabolism and disposition: the biological fate of chemicals 1994;22(1):177-9.
1993: Walle T; Kumar G N; McMillan J M; Thornburg K R; Walle U K
Taxol metabolism in rat hepatocytes.
Biochemical pharmacology 1993;46(9):1661-4.
1993: Kumar G N; Walle U K; Bhalla K N; Walle T
Binding of taxol to human plasma, albumin and alpha 1-acid glycoprotein.
Research communications in chemical pathology and pharmacology 1993;80(3):337-44.
1993: Walle U K; Pesola G R; Walle T
Stereoselective sulphate conjugation of salbutamol in humans: comparison of hepatic, intestinal and platelet activity.
British journal of clinical pharmacology 1993;35(4):413-8.
1993: Eller T D; Walle U K; Walle T
Immunoaffinity isolation of the sulfate conjugate of 4'-hydroxypropranolol from plasma.
Journal of chromatography 1993;612(2):320-5.
1993: Walle T; Walle U K; Thornburg K R; Schey K L
Stereoselective sulfation of albuterol in humans. Biosynthesis of the sulfate conjugate by HEP G2 cells.
Drug metabolism and disposition: the biological fate of chemicals 1993;21(1):76-80.
1993: Pesola G R; Walle T
Stereoselective sulfate conjugation of isoproterenol in humans: comparison of hepatic, intestinal, and platelet activity.
Chirality 1993;5(8):602-9.
1993: Priest D G; Schmitz J C; Walle T
Leucovorin as a prodrug.
Advances in experimental medicine and biology 1993;339():31-40; discussion 41-2.
1992: Shwed J A; Walle U K; Walle T
Hep G2 cell line as a human model for sulphate conjugation of drugs.
Xenobiotica; the fate of foreign compounds in biological systems 1992;22(8):973-82.
1992: Steiner A; Walle U K; Walle T
Induction of propranolol metabolism in the Hep G2 human hepatoma cell line.
The Journal of pharmacy and pharmacology 1992;44(7):611-4.
1992: Steiner A; Walle T
Potent inhibition of MAO mediated propranolol metabolism by dimethyl sulfoxide in Hep G2 cells.
Research communications in chemical pathology and pharmacology 1992;75(3):373-6.
1992: Walle T; Walle U K
Stereoselective sulfate conjugation of 4-hydroxypropranolol and terbutaline by the human liver phenolsulfotransferases.
Drug metabolism and disposition: the biological fate of chemicals 1992;20(2):333-6.
1992: Pesola G R; Walle T
Enantiomeric interaction in the sulfate conjugation of the beta 2-agonist drug albuterol by the human liver.
Research communications in chemical pathology and pharmacology 1992;75(1):125-8.
1991: Walle U K; Walle T
Stereoselective sulfate conjugation of 4-hydroxypropranolol in humans: comparison of platelet and hepatic activity.
Drug metabolism and disposition: the biological fate of chemicals 1991;19(4):838-40.
1991: Walle T; Walle U K
Stereoselective sulfate conjugation of racemic 4-hydroxypropranolol by human and rat liver cytosol.
Drug metabolism and disposition: the biological fate of chemicals 1991;19(2):448-53.
1991: Walle T; Webb J G; Walle U K; Bagwell E E
Stereoselective accumulation of the beta-receptor blocking drug atenolol by human platelets.
Chirality 1991;3(6):451-3.
1990: Walle T; Walle U K
Stereoselective sulphate conjugation of racemic terbutaline by human liver cytosol.
British journal of clinical pharmacology 1990;30(1):127-33.
1990: Nishimiya T; Daniell H B; Webb J G; Oatis J; Walle T; Gaffney T E; Halushka P V
Chronic treatment with propranolol enhances the synthesis of prostaglandins E2 and I2 by the aorta of spontaneously hypertensive rats.
The Journal of pharmacology and experimental therapeutics 1990;253(1):207-13.
1990: Walle T; Walle U K; Cowart T D; Conradi E C; Gaffney T E
Pharmacokinetics and metabolism of oral doses of a 4'-methylthio derivative of propranolol in man.
Xenobiotica; the fate of foreign compounds in biological systems 1990;20(3):321-31.
1990: Walpole H E; Lee W M; Walle T; Walle U K; Wilson M J; Kennedy J W
Rabbit hepatocytes in primary culture: preparation, viability and use in studies of propranolol metabolism.
Hepatology (Baltimore, Md.) 1990;11(3):394-400.
1990: Christ D D; Walle U K; Oatis J E; Walle T
Pharmacokinetics and metabolism of the pharmacologically active 4'-hydroxylated metabolite of propranolol in the dog.
Drug metabolism and disposition: the biological fate of chemicals 1990;18(1):1-4.
1989: Christ D D; Walle T
Stereoselective sulfation of R,S-4'-hydroxypropranolol by canine hepatic cytosol and partially purified phenolsulfotransferases.
The Journal of pharmacology and experimental therapeutics 1989;251(3):949-55.
1989: Pearson A A; Gaffney T E; Walle T; Privitera P J
A stereoselective central hypotensive action of atenolol.
The Journal of pharmacology and experimental therapeutics 1989;250(3):759-63.
1989: Walle T; Walle U K; Cowart T D; Conradi E C
Pathway-selective sex differences in the metabolic clearance of propranolol in human subjects.
Clinical pharmacology and therapeutics 1989;46(3):257-63.
1989: Bai S A; Easterling D E; Wilson M J; Walle U K; Haney C A; Peet N P; Pruett J K; Walle T
Pharmacokinetics and metabolism of a 4'-methylthio derivative of propranolol in the dog.
Drug metabolism and disposition: the biological fate of chemicals 1989;17(5):495-505.
1989: Bagwell E E; Webb J G; Walle T; Gaffney T E
Stereoselective uptake of atenolol into storage granules isolated from PC12 cells.
The Journal of pharmacology and experimental therapeutics 1989;249(2):476-82.
1989: Ward S A; Walle T; Walle U K; Wilkinson G R; Branch R A
Propranolol's metabolism is determined by both mephenytoin and debrisoquin hydroxylase activities.
Clinical pharmacology and therapeutics 1989;45(1):72-9.
1989: Walle U K; Thibodeaux H; Privitera P J; Walle T
Stereochemistry of tissue distribution of racemic propranolol in the dog.
Chirality 1989;1(3):192-6.
1989: Walle U K; Walle T
Stereoselective sulfation of terbutaline by the rat liver cytosol: evaluation of experimental approaches.
Chirality 1989;1(2):121-6.
1988: Webb J G; Street J A; Bagwell E E; Walle T; Gaffney T E
Stereoselective secretion of atenolol from PC12 cells.
The Journal of pharmacology and experimental therapeutics 1988;247(3):958-64.
1988: Wilson M J; Ballard K D; Walle T
Preparative resolution of the enantiomers of the beta-blocking drug atenolol by chiral derivatization and high-performance liquid chromatography.
Journal of chromatography 1988;431(1):222-7.
1988: Hurwitz G A; Webb J G; Walle T; Gourley L A; Cobb L
Enhanced exercise noradrenaline concentrations during propranolol treatment: a limiting factor in cardiac beta-adrenoceptor blockade.
The Canadian journal of cardiology 1988;4(6):262-9.
1988: Daniell H B; Webb J G; Walle T; Oatis J E; Gaffney T E
Inhibitors of prostaglandin synthesis reverse the effects of chronic beta-receptor blockade to attenuate adrenergic neurovascular transmission in dogs.
Journal of cardiovascular pharmacology 1988;12(3):300-7.
1988: Walle T; Webb J G; Bagwell E E; Walle U K; Daniell H B; Gaffney T E
Stereoselective delivery and actions of beta receptor antagonists.
Biochemical pharmacology 1988;37(1):115-24.
1987: Walle T; Walle U K; Cowart T D; Conradi E C; Gaffney T E
Selective induction of propranolol metabolism by smoking: additional effects on renal clearance of metabolites.
The Journal of pharmacology and experimental therapeutics 1987;241(3):928-33.
1987: Fagan T C; Walle T; Oexmann M J; Walle U K; Bai S A; Gaffney T E
Increased clearance of propranolol and theophylline by high-protein compared with high-carbohydrate diet.
Clinical pharmacology and therapeutics 1987;41(4):402-6.
1986: Olanoff L S; Walle T; Cowart T D; Walle U K; Oexmann M J; Conradi E C
Food effects on propranolol systemic and oral clearance: support for a blood flow hypothesis.
Clinical pharmacology and therapeutics 1986;40(4):408-14.
1986: Walle T; Walle U K; Olanoff L S; Conradi E C
Partial metabolic clearances as determinants of the oral bioavailability of propranolol.
British journal of clinical pharmacology 1986;22(3):317-23.
1986: Fagan T C; Gourley L A; Sawyer P R; Lee J T; Walle T; Gaffney T E
Acute hypotensive effects of oral and intravenous propranolol: early alterations in peripheral resistance.
Journal of clinical hypertension 1986;2(1):21-9.
1985: Walle T; Byington R P; Furberg C D; McIntyre K M; Vokonas P S
Biologic determinants of propranolol disposition: results from 1308 patients in the Beta-Blocker Heart Attack Trial.
Clinical pharmacology and therapeutics 1985;38(5):509-18.
1985: Bai S A; Walle U K; Walle T
Influence of food on the intravenous and oral dose kinetics of propranolol in the dog.
Journal of pharmacokinetics and biopharmaceutics 1985;13(3):229-41.
1985: Oatis J E; Walle T; Daniell H B; Gaffney T E; Knapp D R
Synthesis of 4'-hydroxypropranolol sulfate, a major non-beta-blocking propranolol metabolite in man.
Journal of medicinal chemistry 1985;28(6):822-4.
1985: Walle T; Christ D D; Walle U K; Wilson M J
Separation of the enantiomers of intact sulfate conjugates of adrenergic drugs by high-performance liquid chromatography after chiral derivatization.
Journal of chromatography 1985;341(1):213-6.
1985: Christ D D; Walle T
Stereoselective sulfate conjugation of 4-hydroxypropranolol in vitro by different species.
Drug metabolism and disposition: the biological fate of chemicals 1985;13(3):380-1.
1985: Walle T
Stereochemistry of the in vivo disposition and metabolism of propranolol in dog and man using deuterium-labeled pseudoracemates.
Drug metabolism and disposition: the biological fate of chemicals 1985;13(3):279-82.
1985: Walle T; Walle U K; Olanoff L S
Quantitative account of propranolol metabolism in urine of normal man.
Drug metabolism and disposition: the biological fate of chemicals 1985;13(2):204-9.
1984: Walle T; Walle U K; Wilson M J; Fagan T C; Gaffney T E
Stereoselective ring oxidation of propranolol in man.
British journal of clinical pharmacology 1984;18(5):741-8.
1984: Bai S A; Walle T
Isolation, purification, and structure identification of glucuronic acid conjugates of propranolol and alprenolol and their ring-hydroxylated metabolites.
Drug metabolism and disposition: the biological fate of chemicals 1984;12(6):749-54.
1984: Wilson M J; Walle T
Silica gel high-performance liquid chromatography for the simultaneous determination of propranolol and 4-hydroxypropranolol enantiomers after chiral derivatization.
Journal of chromatography 1984;310(2):424-30.
1984: Olanoff L S; Walle T; Walle U K; Cowart T D; Gaffney T E
Stereoselective clearance and distribution of intravenous propranolol.
Clinical pharmacology and therapeutics 1984;35(6):755-61.
1984: Wingstrand K H; Walle T
Isolation from urine of 4'-hydroxypropranolol sulfate, a major new propranolol metabolite, by ion-pair extraction.
Journal of chromatography 1984;305(1):250-5.
1983: Hurwitz G A; Webb J G; Walle T; Bai S A; Daniell H B; Gourley L; Boyd Loadholt C; Gaffney T E
Exercise-induced increments in plasma levels of propranolol and noradrenaline.
British journal of clinical pharmacology 1983;16(6):599-608.
1983: Walle U K; Walle T; Bai S A; Olanoff L S
Stereoselective binding of propranolol to human plasma, alpha 1-acid glycoprotein, and albumin.
Clinical pharmacology and therapeutics 1983;34(6):718-23.
1983: Bai S A; Wilson M J; Walle U K; Walle T
Stereoselective increase in propranolol bioavailability during chronic dosing in the dog.
The Journal of pharmacology and experimental therapeutics 1983;227(2):360-4.
1983: Fagan T C; Walle T; Corns-Hurwitz R; Conradi E C; Privitera P; Harmon G; Degenhart W; Gaffney T E
Time course of development of the antihypertensive effect of propranolol.
Hypertension 1983;5(6):852-7.
1983: Walle T; Wilson M J; Walle U K; Bai S A
Stereochemical composition of propranolol metabolites in the dog using stable isotope-labeled pseudoracemates.
Drug metabolism and disposition: the biological fate of chemicals 1983;11(6):544-9.
1983: Ballard K D; Knapp D R; Oatis J E; Walle T
Resolution of the seven isomeric ring-hydroxylated propranolols as tert.-butyldimethylsilyl derivatives by capillary gas chromatography--mass spectrometry.
Journal of chromatography 1983;277():333-9.
1983: Russell M P; Webb J G; Walle T; Daniell H B; Privitera P J; Gaffney T E
Adrenergic nerve stimulation-induced release of propranolol from the perfused hindlimb and spleen of the dog and associated changes in postjunctional response.
The Journal of pharmacology and experimental therapeutics 1983;226(2):324-9.
1983: Eller T D; Knapp D R; Walle T
Radioimmunoassay of propranolol.
Analytical chemistry 1983;55(9):1572-5.
1983: Bai S A; Walle U K; Wilson M J; Walle T
Stereoselective binding of the (-)-enantiomer of propranolol to plasma and extravascular binding sites in the dog.
Drug metabolism and disposition: the biological fate of chemicals 1983;11(4):394-5.
1983: Walle T; Walle U K; Knapp D R; Conradi E C; Bargar E M
Identification of major sulfate conjugates in the metabolism of propranolol in dog and man.
Drug metabolism and disposition: the biological fate of chemicals 1983;11(4):344-9.
1983: Bargar E M; Walle U K; Bai S A; Walle T
Quantitative metabolic fate of propranolol in the dog, rat, and hamster using radiotracer, high performance liquid chromatography, and gas chromatography-mass spectrometry techniques.
Drug metabolism and disposition: the biological fate of chemicals 1983;11(3):266-72.
1983: Kuye J O; Wilson M J; Walle T
Gas chromatographic analysis of chloroquine after a unique reaction with chloroformates.
Journal of chromatography 1983;272(2):307-13.
1983: Lindenschmidt R; Brown D; Cerimele B; Walle T; Forney R B
Combined effects of propranolol and ethanol on human psychomotor performance.
Toxicology and applied pharmacology 1983;67(1):117-21.
1982: Privitera P J; Walle T; Gaffney T E
Nicotinic-like effects and tissue disposition of isopropylamine.
The Journal of pharmacology and experimental therapeutics 1982;222(1):116-21.
1982: Fagan T C; Walle T; Walle U K; Conradi E C; Harmon G; Gaffney T E
Early kinetics of intravenous propranolol.
British journal of clinical pharmacology 1982;13(4):571-4.
1982: Walle T; Oatis J E; Walle U K; Knapp D R
New ring-hydroxylated metabolites of propranolol: species differences and stereospecific 7-hydroxylation.
Drug metabolism and disposition: the biological fate of chemicals 1982;10(2):122-7.
1981: Walle T; Fagan T C; Walle U K; Oexmann M J; Conradi E C; Gaffney T E
Food-induced increase in propranolol bioavailability--relationship to protein and effects on metabolites.
Clinical pharmacology and therapeutics 1981;30(6):790-5.
1981: Russel M P; Privitera P J; Walle T; Peet N P; Halushka P V; Gaffney T E
Cardiovascular effects of a 4'-methylthio analog of propranolol.
The Journal of pharmacology and experimental therapeutics 1981;219(3):685-90.
1981: Goldszer F; Tindell G L; Walle U K; Walle T
Chemical trapping of labile aldehyde intermediates in the metabolism of propranolol and oxprenolol.
Research communications in chemical pathology and pharmacology 1981;34(2):193-205.
1981: Webb J G; Newman W H; Walle T; Daniell H B
Myocardial sensitivity to isoproterenol following abrupt propranolol withdrawal in conscious dogs.
Journal of cardiovascular pharmacology 1981;3(3):622-35.
1981: Oatis J E; Russell M P; Knapp D R; Walle T
Ring-hydroxylated propranolol: synthesis and beta-receptor antagonist and vasodilating activities of the seven isomers.
Journal of medicinal chemistry 1981;24(3):309-14.
1981: Walle U K; Wilson M J; Walle T
Propranolol, alprenolol and oxprenolol metabolism in the dog. Identification of N-methylated metabolites.
Biomedical mass spectrometry 1981;8(2):78-84.
1980: Riopel D A; Walle T
Kinetic and clinical observations in cyanotic children on propranolol therapy.
Clinical pharmacology and therapeutics 1980;28(6):743-50.
1980: Pruett J K; Walle T; Walle U K
Propranolol effects on membrane repolarization time in isolated canine Purkinje fibers: threshold tissue content and the influence of exposure time.
The Journal of pharmacology and experimental therapeutics 1980;215(2):539-43.
1980: Stone W J; Walle T
Massive propranolol metabolite retention during maintenance hemodialysis.
Clinical pharmacology and therapeutics 1980;28(4):449-55.
1980: Walle T; Conradi E C; Walle U K; Fagan T C; Gaffney T E
4-Hydroxypropranolol and its glucuronide after single and long-term doses of propranolol.
Clinical pharmacology and therapeutics 1980;27(1):22-31.
1979: Walle T; Conradi E C; Walle U K; Fagan T C; Gaffney T E
Propranolol glucuronide cumulation during long-term propranolol therapy: a proposed storage mechanism for propranolol.
Clinical pharmacology and therapeutics 1979;26(6):686-95.
1979: Walle T; Conradi E C; Walle U K; Fagan T C; Gaffney T E
Naphthoxylactic acid after single and long-term doses of propranolol.
Clinical pharmacology and therapeutics 1979;26(5):548-54.
1979: Walle T; Fagan T C; Conradi E C; Walle U K; Gaffney T E
Presystemic and systemic glucuronidation of propranolol.
Clinical pharmacology and therapeutics 1979;26(2):167-72.
1979: Easterling D E; Walle T; Conradi E C; Gaffney T E
Quantitative analysis of naphthoxylactic acid, a major metabolite of propranolol in plasma in man.
Journal of chromatography 1979;162(3):439-45.
1979: Walle T; Walle U K
Stereoselective oral bioavailability of (+/-)-propranolol in the dog. A GC-MS study using a stable isotope technique.
Research communications in chemical pathology and pharmacology 1979;23(3):453-64.
1979: Daniell H B; Walle T; Gaffney T E; Webb J G
Stimulation-induced release of propranolol and norepinephrine from adrenergic neurons.
The Journal of pharmacology and experimental therapeutics 1979;208(3):354-9.
1979: Privitera P J; Webb J G; Walle T
Effects of centrally administered propranolol on plasma renin activity, plasma norepinephrine and arterial pressure.
European journal of pharmacology 1979;54(1-2):51-60.
1978: Walle T; Conradi E C; Walle U K; Fagan T C; Gaffney T E
The predictable relationship between plasma levels and dose during chronic propranolol therapy.
Clinical pharmacology and therapeutics 1978;24(6):668-77.
1978: Walle T; Conradi E C; Walle U K; Gaffney T E
O-methylated catechol-like metabolites of propranolol in man.
Drug metabolism and disposition: the biological fate of chemicals 1978;6(4):481-7.
1978: Tindell G L; Walle T; Knapp D R
Formation of catechol-like and monophenolic metabolites of propranolol by the rat liver 9000G supernatant.
Research communications in chemical pathology and pharmacology 1978;19(1):11-22.
1977: Stillway L W; Walle T
Identification of the unusual polyamines 3,3'-diaminodipropylamine and N,N'-bis(3-aminoproply)-1,3-propanediamine in the white shrimp Penaeus setiferus.
Biochemical and biophysical research communications 1977;77(3):1103-7.
1977: Pruett J K; Walle T; Bagwell E E
Association of in vivo and in vitro propranolol levels in canine Purkinje fibers with antiarrhythmic effects.
The Journal of pharmacology and experimental therapeutics 1977;202(1):45-54.
1977: Saelens D A; Walle T; Gaffney T E; Privitera P J
Studies on the contribution of active metabolites to the anticonvulsant effects of propranolol.
European journal of pharmacology 1977;42(1):39-46.
1977: Blankenship J; Walle T
Acetylation of spermidine and spermine by rat liver and kidney chromatin.
Archives of biochemistry and biophysics 1977;179(1):235-42.
1976: Sealens D A; Walle T; Privitera P J
Quantitative determination of propranolol, propranolol glycol and N-desisopropylpropranolol in brain tissue by electron capture gas chromatography.
Journal of chromatography 1976;123(1):185-92.
1976: Bagwell E E; Walle T; Drayer D E; Reidenbert M M; Pruett J K
Correlation of the electrophysiological and antiarrhythmic properties of the N-acetyl metabolite of procainamide with plasma and tissue drug concentrations in the dog.
The Journal of pharmacology and experimental therapeutics 1976;197(1):38-48.
1975: Walle T
Electron-capture gas chromatography of barbituric acids and diphenylhydantoin after pentafluorobenzylation.
Journal of chromatography 1975;114(2):345-50.
1975: Walle T; Morrison J; Walle K; Conradi E
Simultaneous determination of propranolol and 4-hydroxypropranolol in plasma by mass fragmentography.
Journal of chromatography 1975;114(2):351-9.
1974: Ehrsson H; Walle T; Wikström
Gas chromatography of ether glucuronides as methyl-trifluoroacetyl derivatives.
Journal of chromatography 1974;101(1):206-9.
1974: Walle T
GLC determination of propranolol, other beta-blocking drugs, and metabolites in biological fluids and tissues.
Journal of pharmaceutical sciences 1974;63(12):1885-91.
1974: Walle T; Morrison J I; Tindell G L
Isomeric ring hydroxylated metabolites of propranolol in rats, man and dogs.
Research communications in chemical pathology and pharmacology 1974;9(1):1-10.
1974: Gaffney T E; Knapp D; Walle T; Privitera P; Saelens D
The importance of stable isotope labelled drugs in clinical pharmacology: with illustrations from studies on the disposition of propranolol and nortriptyline in man.
Southern medical journal 1974;67(8):990-1002.
1974: Ishizaki T; Privitera P J; Walle T; Gaffney T E
Cardiovascular actions of a new metabolite of propranolol: isopropylamine.
The Journal of pharmacology and experimental therapeutics 1974;189(3):626-32.
1974: Saelens D A; Walle T; Privitera P J; Knapp D R; Gaffney T
Central nervous system effects and metabolic disposition of a glycol metabolite of propranolol.
The Journal of pharmacology and experimental therapeutics 1974;188(1):86-92.
1973: Gard H; Knapp D; Walle T; Gaffney T; Hanenson I
Qualitative and quantitative studies on the disposition of amitriptyline and other tricyclic antidepressant drugs in man as it relates to the management of the overdosed patient.
Clinical toxicology 1973;6(4):571-84.
1973: Gard H; Knapp D; Hanenson I; Walle T; Gaffney T
Studies on the disposition of amitriptyline and other tricyclic antidepressant drugs in man as it relates to the management of the overdosed patient.
Advances in biochemical psychopharmacology 1973;7():95-105.
1973: Saelens D A; Walle T; Privitera P J; Knapp D R; Gaffney T
The psychopharmacological effects of a new metabolite of propranolol.
Advances in biochemical psychopharmacology 1973;7():107-12.
1972: Walle T; Ehrsson H; Bogentoft C; Dolby J
Synthesis and structure of an enaminic bis(trifluoroacetyl) derivatives of desipramine.
Acta pharmaceutica Suecica 1972;9(6):509-12.
1972: Walle T; Ishizaki T; Gaffney T E
Isopropylamine, a biologically active deamination product of propranolol in dogs: identification of deuterated and unlabeled isopropylamine by gas chromatography-mass spectrometry.
The Journal of pharmacology and experimental therapeutics 1972;183(3):508-12.
1972: Tindell G L; Walle T; Gaffney T E
Rat liver microsomal metabolism of propranolol: identification of seven metabolites by gas chromatography-mass spectrometry.
Life sciences. Pt. 2: Biochemistry, general and molecular biology 1972;11(21):1029-36.
1972: Garteiz D A; Walle T
Electron impact fragmentation studies of beta-blocking drugs and their metabolites by GC-mass spectroscopy.
Journal of pharmaceutical sciences 1972;61(11):1728-31.
1972: Walle T; Gaffney T E
Propranolol metabolism in man and dog: mass spectrometric identification of six new metabolites.
The Journal of pharmacology and experimental therapeutics 1972;182(1):83-92.
1971: Ehrsson H; Walle T; Brötell H
Quantitative gas chromatographic determination of picogram quantities of phenols.
Acta pharmaceutica Suecica 1971;8(3):319-28.
1971: Walle T; Ehrsson H
Quantitative gas chromatographic determination of picogram quantities of amino and alcoholic compounds by electron capture detection.
Acta pharmaceutica Suecica 1971;8(1):27-38.
1970: Ervik M; Walle T; Ehrsson H
Quantitative gas chromatographic determination of nanogram levels of desipramine in serum.
Acta pharmaceutica Suecica 1970;7(6):625-34.
1970: Walle T; Ehrsson H
Quantitative gas chromatographic determination of picogram quantities of amino and alcoholic compounds by electron capture detection. I. Preparation and properties of the heptafluorobutyryl derivatives.
Acta pharmaceutica Suecica 1970;7(4):389-406.
1968: Walle T
Quantitative gas chromatography of picogram quantities of amines as 2,4-dinitrophenyl derivatives.
Acta pharmaceutica Suecica 1968;5(4):367-84.
1968: Walle T
Quantitative gas-chromatographic determination of primary amines in submicrogram quantities after condensation with 2,5-hexanedione.
Acta pharmaceutica Suecica 1968;5(4):353-66.
1966: Walle T; Schill G; Vessman J
Gas chromatographic determination of calciferol in preparations containing vitamin A.
Acta pharmaceutica Suecica 1966;3(3):167-80.

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