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Kent Wallner

Research Profile

Procedures

Brachytherapy

Disorders

Chemicals & Drugs

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Anatomy

Prostate

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TOP 3
Madhu B Shetti; Ashley Torlone; Edward Adamovich; Wayne M Butler; Robert W Galbreath; Jonathan H Lief; Gregory S Merrick; Kent E Wallner
The impact of diabetes mellitus on survival in men with clinically localized prostate cancer treated with permanent interstitial brachytherapy.
Peter F Orio; Wayne M Butler; Robert W Galbreath; Jonathan Lief; Gregory S Merrick; Kent E Wallner
Patient-reported long-term rectal function after permanent interstitial brachytherapy for clinically localized prostate cancer.
Gregory S Merrick; Peter Orio; Al V Taira; Kent E Wallner; Wayne M Butler; Robert W Galbreath; Edward Adamovich
20 Gy versus 44 Gy of supplemental external beam radiotherapy with palladium-103 for patients with greater risk disease: results of a prospective randomized trial.

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2012: Madhu B Shetti; Ashley Torlone; Edward Adamovich; Wayne M Butler; Robert W Galbreath; Jonathan H Lief; Gregory S Merrick; Kent E Wallner
The impact of diabetes mellitus on survival in men with clinically localized prostate cancer treated with permanent interstitial brachytherapy.
American journal of clinical oncology 2012;35(6):572-9.
2012: Peter F Orio; Wayne M Butler; Robert W Galbreath; Jonathan Lief; Gregory S Merrick; Kent E Wallner
Patient-reported long-term rectal function after permanent interstitial brachytherapy for clinically localized prostate cancer.
Brachytherapy 2012;11(5):341-7.
2012: Gregory S Merrick; Peter Orio; Al V Taira; Kent E Wallner; Wayne M Butler; Robert W Galbreath; Edward Adamovich
20 Gy versus 44 Gy of supplemental external beam radiotherapy with palladium-103 for patients with greater risk disease: results of a prospective randomized trial.
International journal of radiation oncology, biology, physics 2012;82(3):e449-55.
2011: L Christine Fang; Robert W Galbreath; Gregory S Merrick; Brian C Murray; Joshua L Reed; Edward Adamovich; Wayne M Butler; Kent E Wallner
High-risk prostate cancer with Gleason score 8-10 and PSA level ≤15 ng/mL treated with permanent interstitial brachytherapy.
International journal of radiation oncology, biology, physics 2011;81(4):992-6.
2011: Benjamin L King; Wayne M Butler; Gregory S Merrick; Brian S Kurko; Joshua L Reed; Brian C Murray; Kent E Wallner
Electromagnetic transponders indicate prostate size increase followed by decrease during the course of external beam radiation therapy.
International journal of radiation oncology, biology, physics 2011;79(5):1350-7.
2011: Al V Taira; Gregory S Merrick; Wayne M Butler; Robert W Galbreath; Jonathan H Lief; Edward Adamovich; Kent E Wallner
Long-term outcome for clinically localized prostate cancer treated with permanent interstitial brachytherapy.
International journal of radiation oncology, biology, physics 2011;79(5):1336-42.
2011: Gregory S Merrick; Wayne M Butler; Robert W Galbreath; Jonathan H Lief; Nathan Bittner; Kent E Wallner; Edward Adamovich
Prostate cancer death is unlikely in high-risk patients following quality permanent interstitial brachytherapy.
BJU international 2011;107(2):226-32.
2010: Al V Taira; Gregory S Merrick; Robert W Galbreath; Wayne M Butler; Jonathan H Lief; Kent E Wallner
Relationship between prostate cancer mortality and number of unfavourable risk factors in men treated with definitive brachytherapy.
BJU international 2010;106(6):809-14.
2010: L Christine Fang; Gregory S Merrick; Kent E Wallner
Androgen deprivation therapy: a survival benefit or detriment in men with high-risk prostate cancer?
Oncology (Williston Park, N.Y.) 2010;24(9):790-6, 798.
2010: Jyoti Mayadev; Gregory S Merrick; Joshua R Reed; Wayne M Butler; Robert W Galbreath; Zachariah A Allen; Kent E Wallner
Permanent prostate brachytherapy in prostate glands <20 cm(3).
International journal of radiation oncology, biology, physics 2010;76(5):1450-5.
2010: Al V Taira; Gregory S Merrick; Robert W Galbreath; Wayne M Butler; Kent E Wallner
Factors impacting all-cause mortality in prostate cancer brachytherapy patients with or without androgen deprivation therapy.
Brachytherapy 2010;9(1):42-9.
2008: Gregory S Merrick; Kent E Wallner; Robert W Galbreath; Wayne M Butler; Sarah G Brammer; Zachariah A Allen; Jonathan H Lief; Edward Adamovich
Biochemical and functional outcomes following brachytherapy with or without supplemental therapies in men < or = 50 years of age with clinically organ-confined prostate cancer.
American journal of clinical oncology 2008;31(6):539-44.
2008: Nathan Bittner; Gregory S Merrick; Robert W Galbreath; Wayne M Butler; Kent E Wallner; Zachariah A Allen; Sarah G Brammer; Mark Moyad
Primary causes of death after permanent prostate brachytherapy.
International journal of radiation oncology, biology, physics 2008;72(2):433-40.
2008: Gregory S Merrick; Kent E Wallner; Robert W Galbreath; Wayne M Butler; Sarah G Brammer; Zachariah A Allen; Edward Adamovich
Prostate brachytherapy in men > or =75 years of age.
International journal of radiation oncology, biology, physics 2008;72(2):415-20.
2008: Gregory S Merrick; Walter Taubenslag; Hugo Andreini; Sarah Brammer; Wayne M Butler; Edward Adamovich; Zachariah A Allen; Richard Anderson; Kent E Wallner
The morbidity of transperineal template-guided prostate mapping biopsy.
BJU international 2008;101(12):1524-9.
2008: Nathan Bittner; Gregory S Merrick; Sarah Brammer; Angela Niehaus; Kent E Wallner; Wayne M Butler; Zachariah A Allen; Robert W Galbreath
Role of trospium chloride in brachytherapy-related detrusor overactivity.
Urology 2008;71(3):460-4.
2007: Laurie J Abel; Debra Zeroski; Sarah Brammer; Wayne Butler; Kent E Wallner; Gregory S Merrick
PSA spike after brachytherapy For localized prostate cancer.
Urologic nursing 2007;27(6):507-10, 518; quiz 511.
2007: Gregory S Merrick; Robert W Galbreath; Wayne M Butler; Kent E Wallner; Zachariah A Allen; Edward Adamovich
Obesity is not predictive of overall survival following permanent prostate brachytherapy.
American journal of clinical oncology 2007;30(6):588-96.
2007: Nathan Bittner; Gregory S Merrick; Kent E Wallner; Jonathan H Lief; Wayne M Butler; Robert W Galbreath
The impact of acute urinary morbidity on late urinary function after permanent prostate brachytherapy.
Brachytherapy 2007;6(4):258-66.
2007: Peter F Orio; Ismail B Tutar; Sreeram Narayanan; Sandra Arthurs; Paul S Cho; Yongmin Kim; Gregory Merrick; Kent E Wallner
Intraoperative ultrasound-fluoroscopy fusion can enhance prostate brachytherapy quality.
International journal of radiation oncology, biology, physics 2007;69(1):302-7.
2007: Chelsea Bostancic; Gregory S Merrick; Wayne M Butler; Kent E Wallner; Zachariah A Allen; Robert W Galbreath; Jonathan H Lief; Sarah E Gutman
Isotope and patient age predict for PSA spikes after permanent prostate brachytherapy.
International journal of radiation oncology, biology, physics 2007;68(5):1431-7.
2007: Gregory S Merrick; Wayne M Butler; Kent E Wallner; Zachariah A Allen; Brian Kurko; Richard L Anderson; Robert Grammer; Robert W Galbreath; Lawrence True; Edward Adamovich
Dosimetry of an extracapsular anulus following permanent prostate brachytherapy.
American journal of clinical oncology 2007;30(3):228-33.
2007: Gregory S Merrick; Wayne M Butler; Kent E Wallner; Robert W Galbreath; Zachariah A Allen; Edward Adamovich; Jonathan H Lief
Androgen deprivation therapy does not impact cause-specific or overall survival in high-risk prostate cancer managed with brachytherapy and supplemental external beam.
International journal of radiation oncology, biology, physics 2007;68(1):34-40.
2007: Daniel R Reed; Kent E Wallner; Gregory S Merrick; Sandra Arthurs; Amy Mueller; William Cavanagh; Wayner B Butler; ERIC FORD; Steven Sutlief
A prospective randomized comparison of stranded vs. loose 125I seeds for prostate brachytherapy.
Brachytherapy 2007;6(2):129-34.
2007: Gregory S Merrick; Wayne M Butler; Kent E Wallner; Robert W Galbreath; Zachariah A Allen; Sarah Gutman; Jonathan H Lief
Long-term rectal function after permanent prostate brachytherapy.
Cancer journal (Sudbury, Mass.) 2007;13(2):95-104.
2007: Steven J Frank; Peter D Grimm; John E Sylvester; Gregory S Merrick; Brian J Davis; Anthony L Zietman; Brian J Moran; David C Beyer; Mack Roach; Daniel H Clarke; Richard G Stock; W Robert Lee; Jeff M Michalski; Kent E Wallner; Mark Hurwitz; Louis Potters; Deborah A Kuban; Bradley R Prestidge; Robyn Vera; Shannon Hathaway; John C Blasko
Interstitial implant alone or in combination with external beam radiation therapy for intermediate-risk prostate cancer: a survey of practice patterns in the United States.
Brachytherapy 2007;6(1):2-8.
2006: Hiroki Mitsuyama; Kent E Wallner; Gregory S Merrick
Treatment of prostate cancer in obese patients.
Oncology (Williston Park, N.Y.) 2006;20(10):1191-7; discussion 1198, 1206, 1208.
2006: Sarah Gutman; Gregory S Merrick; Wayne M Butler; Kent E Wallner; Zachariah A Allen; Robert W Galbreath; Edward Adamovich
Temporal relationship between prostate brachytherapy and the diagnosis of colorectal cancer.
International journal of radiation oncology, biology, physics 2006;66(1):48-55.
2006: Mark A Moyad; Gregory S Merrick; Wayne M Butler; Kent E Wallner; Robert W Galbreath; Earnest G Butler; Zachariah A Allen; Edward Adamovich
Statins, especially atorvastatin, may improve survival following brachytherapy for clinically localized prostate cancer.
Urologic nursing 2006;26(4):298-303.
2006: Gregory S Merrick; Kent E Wallner; Wayne M Butler; Robert W Galbreath; Zachariah A Allen; Edward Adamovich; Lawrence True
Brachytherapy in men aged < or = 54 years with clinically localized prostate cancer.
BJU international 2006;98(2):324-8.
2006: Gregory S Merrick; Wayne M Butler; Kent E Wallner; Robert W Galbreath; Zachariah A Allen; Brian Kurko
Efficacy of neoadjuvant bicalutamide and dutasteride as a cytoreductive regimen before prostate brachytherapy.
Urology 2006;68(1):116-20.
2006: Gregory S Merrick; Wayne M Butler; Kent E Wallner; Robert W Galbreath; Zachariah A Allen; Edward Adamovich
Androgen-deprivation therapy does not impact cause-specific or overall survival after permanent prostate brachytherapy.
International journal of radiation oncology, biology, physics 2006;65(3):669-77.
2006: Gregory S Merrick; Kent E Wallner; Wayne M Butler; John C Blasko
Permanent prostate brachytherapy: is supplemental external-beam radiation therapy necessary?
Oncology (Williston Park, N.Y.) 2006;20(5):514-22; discussion 522-5.
2006: Gregory S Merrick; Wayne M Butler; Kent E Wallner; Robert W Galbreath; Richard L Anderson; Zachariah A Allen; Edward Adamovich
Risk factors for the development of prostate brachytherapy related urethral strictures.
The Journal of urology 2006;175(4):1376-80; discussion 1381.
2006: Sarah Gutman; Gregory S Merrick; Wayne M Butler; Kent E Wallner; Zachariah A Allen; Robert W Galbreath; Edward Adamovich
Severity categories of the International Prostate Symptom Score before, and urinary morbidity after, permanent prostate brachytherapy.
BJU international 2006;97(1):62-8.
2006: Angela Niehaus; Gregory S Merrick; Wayne M Butler; Kent E Wallner; Zachariah A Allen; Robert W Galbreath; Edward Adamovich
The influence of isotope and prostate volume on urinary morbidity after prostate brachytherapy.
International journal of radiation oncology, biology, physics 2006;64(1):136-43.
2005: Megan Beekman; Gregory S Merrick; Wayne M Butler; Kent E Wallner; Zachariah A Allen; Robert W Galbreath
Selecting patients with pretreatment postvoid residual urine volume less than 100 mL may favorably influence brachytherapy-related urinary morbidity.
Urology 2005;66(6):1266-70.
2005: Mark A Moyad; Gregory S Merrick; Wayne M Butler; Kent E Wallner; Robert W Galbreath; Brian Kurko; Edward Adamovich
Statins, especially atorvastatin, may favorably influence clinical presentation and biochemical progression-free survival after brachytherapy for clinically localized prostate cancer.
Urology 2005;66(6):1150-4.
2005: Gregory S Merrick; Wayne M Butler; Kent E Wallner; Robert W Galbreath; Zachariah A Allen; Edward Adamovich
Prognostic significance of perineural invasion on biochemical progression-free survival after prostate brachytherapy.
Urology 2005;66(5):1048-53.
2005: Daniel R Reed; Kent E Wallner; Sreeram Narayanan; Steven Sutlief; ERIC FORD; Paul S Cho
Intraoperative fluoroscopic dose assessment in prostate brachytherapy patients.
International journal of radiation oncology, biology, physics 2005;63(1):301-7.
2005: Zachariah A Allen; Gregory S Merrick; Wayne M Butler; Kent E Wallner; Brian Kurko; Richard L Anderson; Brian C Murray; Robert W Galbreath
Detailed urethral dosimetry in the evaluation of prostate brachytherapy-related urinary morbidity.
International journal of radiation oncology, biology, physics 2005;62(4):981-7.
2005: Gregory S Merrick; Wayne M Butler; Kent E Wallner; Robert W Galbreath; Edward Adamovich
Monotherapeutic brachytherapy for clinically organ-confined prostate cancer.
The West Virginia medical journal 2005;101(4):168-71.
2005: Gregory S Merrick; Kent E Wallner; Wayne M Butler
Prostate cryotherapy: more questions than answers.
Urology 2005;66(1):9-15.
2005: Gregory S Merrick; Wayne M Butler; Kent E Wallner; Robert W Galbreath; Richard L Anderson; Brian Kurko; Jonathan H Lief; Zachariah A Allen
Erectile function after prostate brachytherapy.
International journal of radiation oncology, biology, physics 2005;62(2):437-47.
2005: Gregory S Merrick; Wayne M Butler; Kent E Wallner; Zachariah A Allen; John L DeFilippo; Edward Adamovich
Enzymatic prostatic acid phosphatase in the clinical staging of patients diagnosed with prostate cancer.
The West Virginia medical journal 2005;101(3):116-9.
2005: Gregory S Merrick; Wayne M Butler; Kent E Wallner; Robert W Galbreath; Zachariah A Allen; Edward Adamovich
The impact of primary Gleason grade on biochemical outcome following brachytherapy for hormone-naive Gleason score 7 prostate cancer.
Cancer journal (Sudbury, Mass.) 2005;11(3):234-40.
2005: Gregory S Merrick; Wayne M Butler; Kent E Wallner; Zachariah A Allen; Robert W Galbreath; Jonathan H Lief
Brachytherapy-related dysuria.
BJU international 2005;95(4):597-602.
2005: Gregory S Merrick; Wayne M Butler; Kent E Wallner; John C Blasko; Jeff Michalski; Jesse Aronowitz; Peter D Grimm; Brian J Moran; Patrick W McLaughlin; Jacqueline Usher; Jonathan H Lief; Zachariah A Allen
Variability of prostate brachytherapy pre-implant dosimetry: a multi-institutional analysis.
Brachytherapy 2005;4(4):241-51.
2005: Gregory S Merrick; Wayne M Butler; Kent E Wallner; Zachariah A Allen; Robert W Galbreath; Jonathan H Lief; Daniel J Reed
The impact of radiation dose to the urethra on brachytherapy-related dysuria.
Brachytherapy 2005;4(1):45-50.
2005: Gregory S Merrick; Wayne M Butler; Kent E Wallner; Robert W Galbreath; Zachariah A Allen; Jonathan H Lief; Edward Adamovich
Influence of body mass index on biochemical outcome after permanent prostate brachytherapy.
Urology 2005;65(1):95-100.
2005: Gregory S Merrick; Wayne M Butler; Kent E Wallner; Robert W Galbreath; Jonathan H Lief; Zachariah A Allen; Edward Adamovich
Impact of supplemental external beam radiotherapy and/or androgen deprivation therapy on biochemical outcome after permanent prostate brachytherapy.
International journal of radiation oncology, biology, physics 2005;61(1):32-43.
2004: Gregory S Merrick; Wayne M Butler; Kent E Wallner; Robert W Galbreath; Edward Adamovich
Permanent interstitial brachytherapy for clinically organ-confined high-grade prostate cancer with a pretreatment PSA < 20 ng/mL.
American journal of clinical oncology 2004;27(6):611-5.
2004: Gregory S Merrick; Wayne M Butler; Kent E Wallner; Robert W Galbreath; Edward Adamovich
Permanent interstitial brachytherapy in younger patients with clinically organ-confined prostate cancer.
Urology 2004;64(4):754-9.
2004: Ashley Hinerman-Mulroy; Gregory S Merrick; Wayne M Butler; Kent E Wallner; Zachariah A Allen; Edward Adamovich
Androgen deprivation-induced changes in prostate anatomy predict urinary morbidity after permanent interstitial brachytherapy.
International journal of radiation oncology, biology, physics 2004;59(5):1367-82.
2004: Gregory S Merrick; Wayne M Butler; Kent E Wallner; Zachariah A Allen; Jonathan H Lief; Ashley Hinerman-Mulroy; Robert W Galbreath
The impact of prostate volume and neoadjuvant androgen-deprivation therapy on urinary function following prostate brachytherapy.
Cancer journal (Sudbury, Mass.) 2004;10(3):181-9.
2004: Seungtaek Choi; Kent E Wallner; Gregory S Merrick; William Cavanagh; Wayne M Butler
Treatment margins predict biochemical outcomes after prostate brachytherapy.
Cancer journal (Sudbury, Mass.) 2004;10(3):175-80.
2004: Gregory S Merrick; Kent E Wallner; Wayne M Butler
Patient selection for prostate brachytherapy: more myth than fact.
Oncology (Williston Park, N.Y.) 2004;18(4):445-52; discussion 452, 455-7.
2004: Gregory S Merrick; Wayne M Butler; Kent E Wallner; Robert W Galbreath; Jonathan H Lief; Edward Adamovich
Effect of cigarette smoking on biochemical outcome after permanent prostate brachytherapy.
International journal of radiation oncology, biology, physics 2004;58(4):1056-62.
2004: Gregory S Merrick; Wayne M Butler; Kent E Wallner; Robert W Galbreath; Zachariah A Allen; Edward Adamovich
Temporal effect of neoadjuvant androgen deprivation therapy on PSA kinetics following permanent prostate brachytherapy with or without supplemental external beam radiation.
Brachytherapy 2004;3(3):141-6.
2004: Gregory S Merrick; Wayne M Butler; Kent E Wallner; Brian Murray; Zachariah A Allen; Jonathan H Lief; Robert W Galbreath
The effect of hormonal manipulation on urinary function following permanent prostate brachytherapy.
Brachytherapy 2004;3(1):22-9.
2004: Gregory S Merrick; Wayne M Butler; Kent E Wallner; Robert W Galbreath; Jonathan H Lief; Edward Adamovich
Prognostic significance of percent positive biopsies in clinically organ-confined prostate cancer treated with permanent prostate brachytherapy with or without supplemental external-beam radiation.
Cancer journal (Sudbury, Mass.) 2004;10(1):54-60.
2004: Gregory S Merrick; Wayne M Butler; Kent E Wallner; Robert W Galbreath
Effect of transurethral resection on urinary quality of life after permanent prostate brachytherapy.
International journal of radiation oncology, biology, physics 2004;58(1):81-8.
2004: Gregory S Merrick; Wayne M Butler; Kent E Wallner; Brian C Murray; Zachariah A Allen; Robert W Galbreath
Influence of hormonal therapy on late rectal function after permanent prostate brachytherapy with or without supplemental external beam radiotherapy.
International journal of radiation oncology, biology, physics 2004;58(1):68-74.
2003: Gregory S Merrick; Kent E Wallner; Wayne M Butler
Minimizing prostate brachytherapy-related morbidity.
Urology 2003;62(5):786-92.
2003: Gregory S Merrick; Wayne M Butler; Kent E Wallner; Lauren R Burden; Jackee E Dougherty
Extracapsular radiation dose distribution after permanent prostate brachytherapy.
American journal of clinical oncology 2003;26(5):e178-89.
2003: Gregory S Merrick; Wayne M Butler; Kent E Wallner; Amber L Hines; Zachariah A Allen
Late rectal function after prostate brachytherapy.
International journal of radiation oncology, biology, physics 2003;57(1):42-8.
2003: Daniel R Reed; Kent E Wallner; Gregory Merrick; Wayne Butler; Ben H Han; Steven Sutlief; Paul S Cho
Isodose patterns in patients with inadequate prostate brachytherapy coverage.
International journal of radiation oncology, biology, physics 2003;56(5):1480-7.
2003: Gregory S Merrick; Wayne M Butler; Kent E Wallner; Robert W Galbreath; Jonathan H Lief
Long-term urinary quality of life after permanent prostate brachytherapy.
International journal of radiation oncology, biology, physics 2003;56(2):454-61.
2003: Gregory S Merrick; Kent E Wallner; Wayne M Butler
Permanent interstitial brachytherapy for the management of carcinoma of the prostate gland.
The Journal of urology 2003;169(5):1643-52.
2003: Gregory S Merrick; Wayne M Butler; Kent E Wallner; Robert W Galbreath; Brian Murray; Debra Zeroski; Jonathan H Lief
Dysuria after permanent prostate brachytherapy.
International journal of radiation oncology, biology, physics 2003;55(4):979-85.
2003: Gregory S Merrick; Wayne M Butler; Kent E Wallner; Jonathan H Lief; Ashley Hinerman-Mulroy; Robert W Galbreath
Prostate-specific antigen (PSA) velocity and benign prostate hypertrophy predict for PSA spikes following prostate brachytherapy.
Brachytherapy 2003;2(3):181-8.
2003: Gregory S Merrick; Wayne M Butler; Kent E Wallner; Robert W Galbreath; Brian Kurko; Sabrina Cleavinger
Rectal function following brachytherapy with or without supplemental external beam radiation: results of two prospective randomized trials.
Brachytherapy 2003;2(3):147-57.
2002: Lixin Gong; Paul S Cho; Ben H Han; Kent E Wallner; Steven Sutlief; Sayan D Pathak; David R Haynor; Yongmin Kim
Ultrasonography and fluoroscopic fusion for prostate brachytherapy dosimetry.
International journal of radiation oncology, biology, physics 2002;54(5):1322-30.
2002: Gregory S Merrick; Wayne M Butler; Kent E Wallner; Jonathan H Lief; Richard L Anderson; Benjamin J Smeiles; Robert W Galbreath; Mark L Benson
The importance of radiation doses to the penile bulb vs. crura in the development of postbrachytherapy erectile dysfunction.
International journal of radiation oncology, biology, physics 2002;54(4):1055-62.
2002: Gregory S Merrick; Wayne M Butler; Kent E Wallner; Jonathan H Lief; Robert W Galbreath
Prophylactic versus therapeutic alpha-blockers after permanent prostate brachytherapy.
Urology 2002;60(4):650-5.
2002: Gregory S Merrick; Wayne M Butler; Kent E Wallner; Robert W Galbreath; Richard L Anderson
Prostate-specific antigen spikes after permanent prostate brachytherapy.
International journal of radiation oncology, biology, physics 2002;54(2):450-6.
2002: Kent E Wallner; Gregory S Merrick; Mark L Benson; Wayne M Butler; Jeffrey Maki; Bryan G Tollenaar
Penile bulb imaging.
International journal of radiation oncology, biology, physics 2002;53(4):928-33.
2001: B H Han; Kent E Wallner
Dosimetric and radiographic correlates to prostate brachytherapy-related rectal complications.
International journal of cancer. Journal international du cancer 2001;96(6):372-8.
1998: John C Blasko; Kent E Wallner; William Cavanagh
Radiotherapeutic strategies in the management of clinically localized, "low-risk" prostate cancer: selection, results, and the search for answers.
The cancer journal from Scientific American 1998;4(3):157-8.