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Heidi Wallweber

Research Profile

Chemicals & Drugs

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Publications

TOP 3
Gladys de Leon-Boenig; Christine Everett; Jianwen A Feng; Yvonne Franke; Krista K Bowman; Terry Crawford; Adam R Johnson; Angela Oh; Steven T Staben; Mark Stanley; Melissa A Starovasnik; Heidi J A Wallweber; Jiansheng Wu; Lawren C Wu; Sarah G Hymowitz
The crystal structure of the catalytic domain of the NF-κB inducing kinase reveals a narrow but flexible active site.
Erin C Dueber; J Michael Elliott; Kurt Deshayes; Anna V Fedorova; Anthony M Giannetti; Sarah G Hymowitz; Andreas Lingel; Brigitte Maurer; Allyn J Schoeffler; Eugene Varfolomeev; Domagoj Vucic; Heidi J A Wallweber; Ping Wu; Kerry Zobel; Wayne J Fairbrother
Antagonists induce a conformational change in cIAP1 that promotes autoubiquitination.
Nathaniel C Gordon; Samantha Lien; Jeremy Johnson; Heidi J A Wallweber; Thuy Tran; Bridget Currell; Mary Mathieu; Clifford Quan; Melissa A Starovasnik; Sarah G Hymowitz; Robert F Kelley
Multiple novel classes of APRIL-specific receptor-blocking peptides isolated by phage display.

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All Publications

2012: Gladys de Leon-Boenig; Christine Everett; Jianwen A Feng; Yvonne Franke; Krista K Bowman; Terry Crawford; Adam R Johnson; Angela Oh; Steven T Staben; Mark Stanley; Melissa A Starovasnik; Heidi J A Wallweber; Jiansheng Wu; Lawren C Wu; Sarah G Hymowitz
The crystal structure of the catalytic domain of the NF-κB inducing kinase reveals a narrow but flexible active site.
Structure (London, England : 1993) 2012;20(10):1704-14.
2011: Erin C Dueber; J Michael Elliott; Kurt Deshayes; Anna V Fedorova; Anthony M Giannetti; Sarah G Hymowitz; Andreas Lingel; Brigitte Maurer; Allyn J Schoeffler; Eugene Varfolomeev; Domagoj Vucic; Heidi J A Wallweber; Ping Wu; Kerry Zobel; Wayne J Fairbrother
Antagonists induce a conformational change in cIAP1 that promotes autoubiquitination.
Science (New York, N.Y.) 2011;334(6054):376-80.
2010: Nathaniel C Gordon; Samantha Lien; Jeremy Johnson; Heidi J A Wallweber; Thuy Tran; Bridget Currell; Mary Mathieu; Clifford Quan; Melissa A Starovasnik; Sarah G Hymowitz; Robert F Kelley
Multiple novel classes of APRIL-specific receptor-blocking peptides isolated by phage display.
Journal of molecular biology 2010;396(1):166-77.
2007: Eugene Varfolomeev; John W Blankenship; Sarah M Wayson; Anna V Fedorova; Nobuhiko Kayagaki; Parie Garg; Kerry Zobel; Jasmin Dynek; Linda O Elliott; Heidi J A Wallweber; John A Flygare; Wayne J Fairbrother; Kurt Deshayes; Xiaodong Huang; Domagoj Vucic
IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis.
Cell 2007;131(4):669-81.
2006: Chingwei V Lee; Sarah G Hymowitz; Heidi J A Wallweber; Nathaniel C Gordon; Karen L Billeci; Siao Ping Tsai; Deanne M Compaan; Jianping Yin; Qian Gong; Robert F Kelley; Laura E DeForge; Flavius Martin; Melissa A Starovasnik; Germaine Fuh
Synthetic anti-BR3 antibodies that mimic BAFF binding and target both human and murine B cells.
Blood 2006;108(9):3103-11.
2006: Kerry Zobel; Lan Wang; Eugene Varfolomeev; Matthew C Franklin; Linda O Elliott; Heidi J A Wallweber; David C Okawa; John A Flygare; Domagoj Vucic; Wayne J Fairbrother; Kurt Deshayes
Design, synthesis, and biological activity of a potent Smac mimetic that sensitizes cancer cells to apoptosis by antagonizing IAPs.
ACS chemical biology 2006;1(8):525-33.
2005: Sarah G Hymowitz; Darshana R Patel; Heidi J A Wallweber; Steven Runyon; Minhong Yan; Jianping Yin; Stephanie Shriver; Nathaniel C Gordon; Borlan Pan; Nicholas J Skelton; Robert F Kelley; Melissa A Starovasnik
Structures of APRIL-receptor complexes: like BCMA, TACI employs only a single cysteine-rich domain for high affinity ligand binding.
The Journal of biological chemistry 2005;280(8):7218-27.
2005: Domagoj Vucic; Matthew C Franklin; Heidi J A Wallweber; Kanad Das; Brendan P Eckelman; Hwain Shin; Linda O Elliott; Saloumeh Kadkhodayan; Kurt Deshayes; Guy S Salvesen; Wayne J Fairbrother
Engineering ML-IAP to produce an extraordinarily potent caspase 9 inhibitor: implications for Smac-dependent anti-apoptotic activity of ML-IAP.
The Biochemical journal 2005;385(Pt 1):11-20.
2004: Heidi J A Wallweber; Deanne M Compaan; Melissa A Starovasnik; Sarah G Hymowitz
The crystal structure of a proliferation-inducing ligand, APRIL.
Journal of molecular biology 2004;343(2):283-90.
2004: Darshana R Patel; Heidi J A Wallweber; JianPing Yin; Stephanie Shriver; Scot A Marsters; Nathaniel C Gordon; Melissa A Starovasnik; Robert F Kelley
Engineering an APRIL-specific B cell maturation antigen.
The Journal of biological chemistry 2004;279(16):16727-35.
2003: Sarah G Hymowitz; Deanne M Compaan; Minhong Yan; Heidi J A Wallweber; Xiaodong Huang; Melissa A Starovasnik; Abraham M de Vos
The crystal structures of EDA-A1 and EDA-A2: splice variants with distinct receptor specificity.
Structure (London, England : 1993) 2003;11(12):1513-20.