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John Bradley

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John P Waters; Jordan S Pober; John R Bradley
Tumour necrosis factor in infectious disease.
Rafia S Al-Lamki; Sarah Finlay; WanHua Lu; Aviva M Tolkovsky; Jason P Twohig; Eddie C Y Wang; John R Bradley
DR3 signaling protects against cisplatin nephrotoxicity mediated by tumor necrosis factor.
Tai Yi; Deepak A Rao; William C Sessa; George Tellides; Zuzana Tobiasova; Chen Wang; Rafia S Al-Lamki; Alfred L M Bothwell; John R Bradley; Birgit Fogal; Zhengrong Hao; Nancy C Kirkiles-Smith; Sanjay Kulkarni; Jordan S Pober
Reperfusion injury intensifies the adaptive human T cell alloresponse in a human-mouse chimeric artery model.

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All Publications

2013: John P Waters; Jordan S Pober; John R Bradley
Tumour necrosis factor in infectious disease.
The Journal of pathology 2013;230(2):132-47.
2012: Rafia S Al-Lamki; Sarah Finlay; WanHua Lu; Aviva M Tolkovsky; Jason P Twohig; Eddie C Y Wang; John R Bradley
DR3 signaling protects against cisplatin nephrotoxicity mediated by tumor necrosis factor.
The American journal of pathology 2012;180(4):1454-64.
2012: Tai Yi; Deepak A Rao; William C Sessa; George Tellides; Zuzana Tobiasova; Chen Wang; Rafia S Al-Lamki; Alfred L M Bothwell; John R Bradley; Birgit Fogal; Zhengrong Hao; Nancy C Kirkiles-Smith; Sanjay Kulkarni; Jordan S Pober
Reperfusion injury intensifies the adaptive human T cell alloresponse in a human-mouse chimeric artery model.
Arteriosclerosis, thrombosis, and vascular biology 2012;32(2):353-60.
2010: Rafia S Al-Lamki; Timothy J Sadler; Jun Wang; Martin J Reid; Anne Y Warren; Mehregan Movassagh; Wanhua Lu; Ian Mills; David E Neal; Johanna Burge; Peter Vandenebeele; Jordan S Pober; John R Bradley
Tumor necrosis factor receptor expression and signaling in renal cell carcinoma.
The American journal of pathology 2010;177(2):943-54.
2009: Rafia S Al-Lamki; A P Brookes; Jun Wang; M J Reid; J Parameshwar; M J Goddard; G Tellides; T Wan; Wang Min; Jordan S Pober; John R Bradley
TNF receptors differentially signal and are differentially expressed and regulated in the human heart.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2009;9(12):2679-96.
2009: Jordan S Pober; Wang Min; John R Bradley
Mechanisms of endothelial dysfunction, injury, and death.
Annual review of pathology 2009;4():71-95.
2008: Rafia S Al-Lamki; John R Bradley; Jordan S Pober
Endothelial cells in allograft rejection.
Transplantation 2008;86(10):1340-8.
2008: Rafia S Al-Lamki; Jun Wang; Aviva M Tolkovsky; J Andrew Bradley; Jules L Griffin; Sathia Thiru; Eddie C Y Wang; Eleanor Bolton; Wang Min; Paul Moore; Jordan S Pober; John R Bradley
TL1A both promotes and protects from renal inflammation and injury.
Journal of the American Society of Nephrology : JASN 2008;19(5):953-60.
2008: A S Thakor; T F Hiemstra; John R Bradley
A rare life-threatening complication of an indwelling hemodialysis catheter.
Kidney international 2008;73(2):244.
2005: Rafia S Al-Lamki; Jun Wang; Peter Vandenabeele; J Andrew Bradley; Sathia Thiru; Dianghong Luo; Wang Min; Jordan S Pober; John R Bradley
TNFR1- and TNFR2-mediated signaling pathways in human kidney are cell type-specific and differentially contribute to renal injury.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005;19(12):1637-45.
2005: Christopher J E Watson; John Firth; Paul F Williams; John R Bradley; Nicholas Pritchard; Afzal Chaudhry; Jane C Smith; Christopher R Palmer; J Andrew Bradley
A randomized controlled trial of late conversion from CNI-based to sirolimus-based immunosuppression following renal transplantation.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2005;5(10):2496-503.
2005: Christopher J E Watson; J Andrew Bradley; Peter J Friend; John Firth; Craig J Taylor; John R Bradley; Kenneth G C Smith; Sathia Thiru; Neville V Jamieson; Geoff Hale; Herman Waldmann; Roy Y Calne
Alemtuzumab (CAMPATH 1H) induction therapy in cadaveric kidney transplantation--efficacy and safety at five years.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2005;5(6):1347-53.
2005: Alessio D'Alessio; Rafia S Al-Lamki; John R Bradley; Jordan S Pober
Caveolae participate in tumor necrosis factor receptor 1 signaling and internalization in a human endothelial cell line.
The American journal of pathology 2005;166(4):1273-82.
2005: Geoffrey R Bihl; Nicholas J Bird; Christina Peters; John R Bradley; A Michael Peters
Radionuclide method for evaluating the performance of hemodialysis in vivo.
Kidney international 2005;67(2):721-31.
2003: Rafia S Al-Lamki; Jun Wang; Sathia Thiru; Nicholas R Pritchard; J Andrew Bradley; Jordan S Pober; John R Bradley
Expression of silencer of death domains and death-receptor-3 in normal human kidney and in rejecting renal transplants.
The American journal of pathology 2003;163(2):401-11.
2003: Emanuele Cozzi; Conrad Vial; Daniel J Ostlie; Bhatti Farah; Gilberto Chavez; Kenneth G C Smith; John R Bradley; Sathia Thiru; Hugh F S Davies; John Wallwork; David J G White; Martin Goddard; Peter J Friend
Maintenance triple immunosuppression with cyclosporin A, mycophenolate sodium and steroids allows prolonged survival of primate recipients of hDAF porcine renal xenografts.
Xenotransplantation 2003;10(4):300-10.
2003: Jun Wang; Rafia S Al-Lamki; Hui Zhang; Nancy C Kirkiles-Smith; Mary Lou Gaeta; Sathia Thiru; Jordan S Pober; John R Bradley
Histamine antagonizes tumor necrosis factor (TNF) signaling by stimulating TNF receptor shedding from the cell surface and Golgi storage pool.
The Journal of biological chemistry 2003;278(24):21751-60.
2001: Rafia S Al-Lamki; Jun Wang; Jeremy N Skepper; Sathia Thiru; Jordan S Pober; John R Bradley
Expression of tumor necrosis factor receptors in normal kidney and rejecting renal transplants.
Laboratory investigation; a journal of technical methods and pathology 2001;81(11):1503-15.
2001: John R Bradley; Jordan S Pober
Tumor necrosis factor receptor-associated factors (TRAFs).
Oncogene 2001;20(44):6482-91.
2001: B Soin; Kenneth G C Smith; A Zaidi; Emanuele Cozzi; John R Bradley; Daniel J Ostlie; ANDREW LOCKHART; David J G White; Peter J Friend
Physiological aspects of pig-to-primate renal xenotransplantation.
Kidney international 2001;60(4):1592-7.
2001: X Feng; Mary Lou Gaeta; Lisa A Madge; Jing-Hua Yang; John R Bradley; Jordan S Pober
Caveolin-1 associates with TRAF2 to form a complex that is recruited to tumor necrosis factor receptors.
The Journal of biological chemistry 2001;276(11):8341-9.
2000: S Masroor; Emanuele Cozzi; B Soin; Conrad Vial; Gilberto Chavez; Kenneth G C Smith; John R Bradley; David J G White; Peter J Friend
Absence of hyperacute rejection and preservation of function in HDAF transgenic pig kidneys exposed to prolonged cold ischaemia.
Transplantation proceedings 2000;32(5):965-6.
2000: Emanuele Cozzi; Farzana Bhatti; Michael Schmoeckel; Gilberto Chavez; Kenneth G C Smith; A Zaidi; John R Bradley; Sathia Thiru; Martin Goddard; Conrad Vial; Daniel J Ostlie; John Wallwork; David J G White; Peter J Friend
Long-term survival of nonhuman primates receiving life-supporting transgenic porcine kidney xenografts.
Transplantation 2000;70(1):15-21.
2000: B Soin; Daniel J Ostlie; Emanuele Cozzi; Kenneth G C Smith; John R Bradley; Conrad Vial; S Masroor; Richard Lancaster; David J G White; Peter J Friend
Growth of porcine kidneys in their native and xenograft environment.
Xenotransplantation 2000;7(2):96-100.
2000: Alison R Hayman; AJ Bune; John R Bradley; J Rashbass; Timothy M Cox
Osteoclastic tartrate-resistant acid phosphatase (Acp 5): its localization to dendritic cells and diverse murine tissues.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2000;48(2):219-28.
1999: EC Ledgerwood; Jordan S Pober; John R Bradley
Recent advances in the molecular basis of TNF signal transduction.
Laboratory investigation; a journal of technical methods and pathology 1999;79(9):1041-50.
1999: PR Faraco; EC Ledgerwood; Peter Vandenabeele; Johannes B Prins; John R Bradley
Tumor necrosis factor induces distinct patterns of caspase activation in WEHI-164 cells associated with apoptosis or necrosis depending on cell cycle stage.
Biochemical and biophysical research communications 1999;261(2):385-92.
1999: S J Jones; EC Ledgerwood; Johannes B Prins; J Galbraith; DR Johnson; Jordan S Pober; John R Bradley
TNF recruits TRADD to the plasma membrane but not the trans-Golgi network, the principal subcellular location of TNF-R1.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(2):1042-8.
1998: Johannes B Prins; EC Ledgerwood; P Ameloot; Peter Vandenabeele; PR Faraco; Nicholas A Bright; Stephen O'Rahilly; John R Bradley
Tumor necrosis factor-induced cytotoxicity is not related to rates of mitochondrial morphological abnormalities or autophagy-changes that can be mediated by TNFR-I or TNFR-II.
Bioscience reports 1998;18(6):329-40.
1998: EC Ledgerwood; Johannes B Prins; Nicholas A Bright; DR Johnson; K Wolfreys; Jordan S Pober; Stephen O'Rahilly; John R Bradley
Tumor necrosis factor is delivered to mitochondria where a tumor necrosis factor-binding protein is localized.
Laboratory investigation; a journal of technical methods and pathology 1998;78(12):1583-9.
1998: EC Ledgerwood; Johannes B Prins; Nicholas A Bright; DR Johnson; K Wolfreys; Jordan S Pober; Stephen O'Rahilly; John R Bradley
Tumour necrosis factor is trafficked to a mitochondrial tumour necrosis factor binding protein.
Biochemical Society transactions 1998;26(4):S316.
1998: Wang Min; John R Bradley; J J Galbraith; S J Jones; EC Ledgerwood; Jordan S Pober
The N-terminal domains target TNF receptor-associated factor-2 to the nucleus and display transcriptional regulatory activity.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(1):319-24.
1996: John R Bradley; Jordan S Pober
Prolonged cytokine exposure causes a dynamic redistribution of endothelial cell adhesion molecules to intercellular junctions.
Laboratory investigation; a journal of technical methods and pathology 1996;75(4):463-72.
1996: M Rocío Sierra-Honigmann; John R Bradley; Jordan S Pober
"Cytosolic" phospholipase A2 is in the nucleus of subconfluent endothelial cells but confined to the cytoplasm of confluent endothelial cells and redistributes to the nuclear envelope and cell junctions upon histamine stimulation.
Laboratory investigation; a journal of technical methods and pathology 1996;74(3):684-95.
1995: John R Bradley; Sathia Thiru; Jordan S Pober
Hydrogen peroxide-induced endothelial retraction is accompanied by a loss of the normal spatial organization of endothelial cell adhesion molecules.
The American journal of pathology 1995;147(3):627-41.
1995: John R Bradley; Sathia Thiru; Jordan S Pober
Disparate localization of 55-kd and 75-kd tumor necrosis factor receptors in human endothelial cells.
The American journal of pathology 1995;146(1):27-32.
1994: John R Bradley; CM Lockwood; Sathia Thiru
Endothelial cell activation in patients with systemic vasculitis.
QJM : monthly journal of the Association of Physicians 1994;87(12):741-5.
1994: John R Bradley; D Wilks; D Rubenstein
The vascular endothelium in septic shock.
The Journal of infection 1994;28(1):1-10.
1993: John R Bradley; David R Johnson; Jordan S Pober
Four different classes of inhibitors of receptor-mediated endocytosis decrease tumor necrosis factor-induced gene expression in human endothelial cells.
Journal of immunology (Baltimore, Md. : 1950) 1993;150(12):5544-55.
1993: John R Bradley; D R Johnson; Jordan S Pober
Endothelial activation by hydrogen peroxide. Selective increases of intercellular adhesion molecule-1 and major histocompatibility complex class I.
The American journal of pathology 1993;142(5):1598-609.
1990: John R Bradley; J R Anderson; D B Evans; A J Cowley
Impaired nutritive skeletal muscle blood flow in patients with chronic renal failure.
Clinical science (London, England : 1979) 1990;79(3):239-45.
1990: John R Bradley; D B Evans; A J Cowley
Comparison of vascular tone during combined haemodialysis with ultrafiltration and during ultrafiltration followed by haemodialysis: a possible mechanism for dialysis hypotension.
BMJ (Clinical research ed.) 1990;300(6735):1312.
1988: John R Bradley; D B Evans; S M Gore; A J Cowley
Is dialysis hypotension caused by an abnormality of venous tone?
British medical journal (Clinical research ed.) 1988;296(6637):1634-7.
1988: John R Bradley; D B Evans; A J Cowley
Abnormalities of the peripheral circulation in patients with chronic renal failure.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 1988;3(4):412-6.
1988: John R Bradley; Sathia Thiru; N Bajallan; D B Evans
Renal transplantation in Waldenström's macroglobulinaemia.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 1988;3(2):214-6.
1987: John R Bradley; Sathia Thiru; D B Evans
Light chains and the kidney.
Journal of clinical pathology 1987;40(1):53-60.
1986: John R Bradley; J Reynolds; P F Williams; D S Appleton
Encephalopathy in renovascular hypertension associated with the use of oral contraceptives.
Postgraduate medical journal 1986;62(733):1031-3.
1986: G A Ford; John R Bradley; D S Appleton; S Thiru; R Y Calne
Spontaneous splenic rupture in polyarteritis nodosa.
Postgraduate medical journal 1986;62(732):965-6.
1985: John R Bradley; P F Williams; D B Evans
Aortic valve replacement in chronic renal failure.
Lancet 1985;2(8468):1370.